<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XF32</accession>
    <name>A0A173XF32_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ureG_1</name>
        <name evidence="4" type="synonym">ureG</name>
        <name evidence="6" type="ORF">ERS852471_00015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49626">
        <property type="protein sequence ID" value="CUN49626"/>
        <property type="gene ID" value="ERS852471_00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN49626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="203" mass="22443" checksum="27775530E87309D1" modified="2016-09-07" version="1">MRPVVIGVGGPVGAGKTLLIERVTRQMAKDYELAVITNDIYTKEDAKFMVENSVLEEGRIIGVETGGCPHTAIREDASMNFAAIEELKNKFTNLDIIFVESGGDNLAATFSPDLVDFSMYIIDVAQGEKIPRKAGQGMIKSDLFVINKIDLAPYVGANLDVMREDTLTFRGEKDFIFTNLKTDEGIETIIKWIKEKCLLEGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKM1</accession>
    <name>A0A173XKM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262758.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52391">
        <property type="protein sequence ID" value="CUN52391"/>
        <property type="gene ID" value="ERS852471_00061"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1564524at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="182" mass="19719" checksum="A76661284597FA95" modified="2016-09-07" version="1">MNLNKINSKKLVLSGLFIAIGLILPSITMQIPSIGNMLCPMHIPVILAGFICGAPYGLVVGFVVPLLRSVTFGAPPLMPIATAMAFELATYGLVSGIMYSRVKDKKIGVYISLITAMILGRAVWGVVSYGLFTALGNQFTWQIFMMQAFVNAIPGIIIQLVFIPILVIKIKASEARRISYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLD3</accession>
    <name>A0A173XLD3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uapC</name>
        <name evidence="8" type="ORF">ERS852471_00064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262762.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52473">
        <property type="protein sequence ID" value="CUN52473"/>
        <property type="gene ID" value="ERS852471_00064"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1419334at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN52473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="449" mass="46813" checksum="332EA748F75EADCB" modified="2016-09-07" version="1">MMNSQNLDTKIKLTYEVDDNPSLSKKILFGLQHIFAAFGGIVVVPLVIAGALGFDGKTTTTLISATILASGLATIIQAKGVGRAGSKVACIMGTDFTFVSPSISVGSVLGLPGIIGATILGAFFEIILSFFIKPLMKLFPPLVTGTVVCLIGLTLLPVSIDWAAGGSGSAEYGSMLNISIAIAVLIITLALNHYGKGLLSSASILIGMVVGYIICIPFGLVDFAPIREAGWLSFPKIFEYGVQFDLKALIAFLPAYFVTTIETVGCLKAVGETSQVEMNEKRVGSGVLADGIGSIIGGLLGSFPNTSFSQNVGLISLTKVASRYVAVAAGAILVCLGFLPKLAALINSIPQPVLGGVGIVMFGTVAAAGIKTLSRVKLTERNLLIIATAIGLGLGVTFRPEFIEQLPEALKMIFASGISTGTIVALILNLVLREDKEEIEETKNEKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLL3</accession>
    <name>A0A173XLL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262732.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51298">
        <property type="protein sequence ID" value="CUN51298"/>
        <property type="gene ID" value="ERS852471_00045"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1606823at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008589">
        <property type="entry name" value="MupG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043894">
        <property type="entry name" value="MupG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043797">
        <property type="entry name" value="MupG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38435">
        <property type="entry name" value="PTHR38435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05913">
        <property type="entry name" value="DUF871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19200">
        <property type="entry name" value="DUF871_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF871_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF871" evidence="1">
        <location>
            <begin position="247"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN51298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="359" mass="41404" checksum="2B7431995BB9008D" modified="2016-09-07" version="1">MSLGFSIYFGLDNTMEENLQLLKDGKNLGFTRIFTSLHIPEADYSILKSQVKEFFKIAKEYDMDIISDISPNTFKFLNLDNMDLKGLSEIGVKTIRVDFGYNEEEIAKMSRNPYGIKVQLNGSTVTEEFLLKLDKLEVEYKNIDALHNFYPRAGTGISIEYMEKQNKLLSKRGIKVSSFIQSNNRKRGPIKEGLPTLENHRNLDVRIAANELFALGNETVFIGDSLPSIQELKELSLLKQDEIMLDIEVMVKDDIINRLLKETYTPRVDQARDAIRAVESRYNLNGDIIIPMNTIDSEIGYITIDNIEYGRYMGELQILKVNKKRDYRINVVAKVSENSLHLLRYIDEGKKFSFYNKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRE7</accession>
    <name>A0A173XRE7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tehB_1</name>
        <name evidence="2" type="ORF">ERS852471_00103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262835.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54249">
        <property type="protein sequence ID" value="CUN54249"/>
        <property type="gene ID" value="ERS852471_00103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015985">
        <property type="entry name" value="TehB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03848">
        <property type="entry name" value="TehB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TehB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="22658" checksum="6B3AED9DD4DD9A6E" modified="2016-09-07" version="1">MKNETLNYYNENAKEYFEITKTLKTSDIYTAFLNSVKSGGKILDLGCGSGRDSLYFKNAGYDVTAVDGSVKLAKEAEKLINQDVIVSKFEDLELNQKFDGIWACASLLHVKRENIEEVLRKLSNNLKEGAVFYLSFKCGDNEYVDERGRYFNCYREESFIEMIKKIKEYDIKNIYITGDSLGGRDNLTWLNVLLQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXG4</accession>
    <name>A0A173XXG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56299">
        <property type="protein sequence ID" value="CUN56299"/>
        <property type="gene ID" value="ERS852471_00144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN56299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="49" mass="5986" checksum="A2E954A568292DCF" modified="2016-09-07" version="1">MNKWDDLAMVTFIACDVIIENTENFKLFSNYFYKNLKYEAKDILKRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8G6</accession>
    <name>A0A173Y8G6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263039.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59860">
        <property type="protein sequence ID" value="CUN59860"/>
        <property type="gene ID" value="ERS852471_00214"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2206374at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN59860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="146" mass="17495" checksum="1F6687745FC1727F" modified="2016-09-07" version="1">MIIININNYTDFYSNNNILETRKLRIDKLIQRDNSLIFEQNTIKFRCEEELLVIIRNVKTKEEFICDYLIKANNLVIILDSLLHLFSNYEGAIQILNKSDEKYYLYNPIMKNNNIINEKIANNKQYKWFIRVLENGEIRLSSIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJ99</accession>
    <name>A0A173YJ99_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyadenosine kinase</fullName>
            <ecNumber evidence="6">2.7.1.113</ecNumber>
            <ecNumber evidence="6">2.7.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.113" evidence="6"/>
    <dbReference type="EC" id="2.7.1.76" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263127.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63650">
        <property type="protein sequence ID" value="CUN63650"/>
        <property type="gene ID" value="ERS852471_00248"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004136">
        <property type="term" value="F:deoxyadenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004138">
        <property type="term" value="F:deoxyguanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="5">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN63650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="25606" checksum="F11AA6DB80AB67F1" modified="2016-09-07" version="1">MVIVVGGMIGLGKSSVAEILGEHFKSEVFYESVDDNPILPLFYSETEEEIAKKRYPFLLQLYFLNTRFKSIKDALHYDNNVLDRSIYEDWYFAKKNMELGRISELEMNIYEGLLNNMMSELEELPKKAPDIMVYLKGSFETVMKRINLRGRDFEIDDSLRDYYHFLWEDYDNWINNYYNASEVVVIDMDNLDVVNNEDDKEILIKLVEEKLREVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YLS7</accession>
    <name>A0A173YLS7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rnjA_1</name>
        <name evidence="9" type="synonym">rnj</name>
        <name evidence="12" type="ORF">ERS852471_00274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263171.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65062">
        <property type="protein sequence ID" value="CUN65062"/>
        <property type="gene ID" value="ERS852471_00274"/>
    </dbReference>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="364"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN65062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="555" mass="61585" checksum="01DABBCE3216B3E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPK5</accession>
    <name>A0A173YPK5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="6" type="ORF">ERS852471_00295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263211.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66091">
        <property type="protein sequence ID" value="CUN66091"/>
        <property type="gene ID" value="ERS852471_00295"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN66091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="28534" checksum="61C6F7B407B4EF39" modified="2016-09-07" version="1">MSNIITPEIQVKNLDLFYGDNQALKNINIDIEKNKVTALIGPSGCGKSTFLRTLNRMNDLIAGVKIDGEILVDGKDIYKDFNEIDLRKKVGMVFQKPNPFPMSIYDNIAYGPRVHGVKDKKTLDQIVEKSLKGAALWDEVKDRLKKGALGLSGGQQQRLCIARTIAVSPEIILMDEPTSALDPISTNKMEELMDQLKKDYTVVIVTHNMQQAGRIADKTAFFLSGELIEYGKTEDIFYRPQDKRTEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YTQ4</accession>
    <name>A0A173YTQ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00255 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yicC</name>
        <name evidence="3" type="ORF">ERS852471_00304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263229.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66616">
        <property type="protein sequence ID" value="CUN66616"/>
        <property type="gene ID" value="ERS852471_00304"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="33584" checksum="540AD6F87447AE8D" modified="2016-09-07" version="1">MVKSMTSFGRSSSEEGQKRIFTVEMKSVNNRYLDINIRMPKALISLEEEVRKMISSSLSRGKVDVFINLKNYSQNEGTPKVDLKLAEDYLNCLREIETNFGLKNDVSVMQLARFPEVITVVQEEEKVEEIFEELKPLISTSIEMMINMRIVEGEKLKEDILDKVSVIEDLVREIEKVADTVPKAYKVKLEERLSELLSGADIDQNRLATEVCIFADKATVDEEITRLGSHISQIRKTLSLNEPIGRKLDFIIQEMNRETNTIGSKSSDIHMTNIVIDIKNLIEKIREQVQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z1E2</accession>
    <name>A0A173Z1E2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">tsf</name>
        <name evidence="10" type="ORF">ERS852471_00355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263316.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69529">
        <property type="protein sequence ID" value="CUN69529"/>
        <property type="gene ID" value="ERS852471_00355"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN69529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="303" mass="33139" checksum="8EDE45C94FE60BC1" modified="2016-09-07" version="1">MITAKSVKELREMTGAGMMDCKKALVATEGDIEKAVEFLREKGLAAAAKKAGRVAAEGIVKTFVSADKKTAGMVEVNCETDFVAANDEFVSFATKVAEMAANTSATTVEELVAEKFEGETTVQEALTALIAKLGENMTVRRFVKFNIENGAIASYIHGGGRIGVMVEVSCDTDSAILEEVAREVCMQVAAANPLFLSREQVDNESLEKEKEIYRVQALNEGKPENIVEKMVMGRIQKYYKEVCLLDQAWVKDGDKSIAKFLEEKSKEVGSPIAITRYARFERGEGIEKVEEDFAAEVAKTMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z4E6</accession>
    <name>A0A173Z4E6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">ERS852471_00374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263352.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70579">
        <property type="protein sequence ID" value="CUN70579"/>
        <property type="gene ID" value="ERS852471_00374"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="6"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN70579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="317" mass="34527" checksum="3248D42AB8A11878" modified="2016-09-07" version="1">MRVAFVFSGQGSQYVGMGKELYENFQEAKRIFDDANEVLDFDLKNLTFNGDAEELNITENTQPAILTMSIAALEVLKNKGIEAEVVAGLSLGEYSALVASGAVSFKDAVALVKKRGKYMQEAVPLGIGAMTAIMGLSIEKIEEAIEMSKDKGIVQIANYNTANQIVIGGELEAVNFAANLCLEYGAKRAISLKVSGPFHTVLLEPAAIKLKEELSNISFSNIKIPVINNVTAEEIKKDDDIKDILGKQVKSSVRWRETIEKMIDMGIDTFIEIGPGRTLSSFIKEIARANKAKVNIFNVEDLKSLNKTLEGVGDLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z677</accession>
    <name>A0A173Z677_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome endopeptidase complex, archaeal, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263395.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71892">
        <property type="protein sequence ID" value="CUN71892"/>
        <property type="gene ID" value="ERS852471_00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016626" evidence="2">
        <location>
            <begin position="23"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN71892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="243" mass="26909" checksum="48F20637234BCA9B" modified="2016-09-07" version="1">MLKKIICNTIIFFMLITLTANATTIIAVIGENKIMLAADTRLTITKKNGEKIHDDTGKKLFKLKNGVGVAFAGDTNSIKTLRSGKDIITKSVSTIINDLNNLSCIEELTVADTAELIAEKYVNLLIDYTGDILVVGFDNDEPVIYGIKAVKGRAIWQGISGKGSFWAIGSGSEMMVNKLRENVGCEEDNNMDLCMDHLKNLKDREILSIVKESLQEVIDDYEENYREEERSTGGKVETLIIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZA50</accession>
    <name>A0A173ZA50_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">ldh</name>
        <name evidence="12" type="ORF">ERS852471_00411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263415.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72519">
        <property type="protein sequence ID" value="CUN72519"/>
        <property type="gene ID" value="ERS852471_00411"/>
    </dbReference>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
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        <property type="entry name" value="L-lactate_DH_AS"/>
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        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="143"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="173"/>
        </location>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
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        <ligand>
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        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <position position="141"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CUN72519.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="312" mass="34127" checksum="7042CB48B396A5DE" modified="2016-09-07" version="1">MSKISIIGAGSIGATTAFALLQKGIAREIVINDINQEKALGEVMDLMHGSSLCKPCNVTLGTIEDTKDSDVVIITAGLNQKPGETRLDLVDKNYGIFKDFIPKIAKASPNAILLVVSNPVDILAYMTYKLSGFPKERVIGSGTVLDTARLRSLLGKYFEIDGRTIDGFVMGEHGDSEFVPWSSLRVGTIPVKSFSEQNSIEWDCETEKVISEDVKNCAYEVINRKGATAFAVAVALVRIVEALLRDEKTILTVSTLLNDYCGVSDTYLSVPTIVGKNGVEKVLKVDFSDEEKEKFTSSARIMREYIDRINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBM0</accession>
    <name>A0A173ZBM0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
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    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN73387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="6503" checksum="E4E488068F6011FB" modified="2016-09-07" version="1">MKKLIILGLITLSLFVSCGNNTTPNDNKDNKATDTTDYGKEAPSTNSNETDSNTNTNQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCN6</accession>
    <name>A0A173ZCN6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenium-dependent hydroxylase accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR03172"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="28359" checksum="9ACD4E2E0561ED0C" modified="2016-09-07" version="1">MKVVKIKENKNINKEYLYEGLEVDLDKKYVISFIGGGGKTTSIYQLAEELSSKGKRVIVTTTTHMQMPKDKVILNNNIDEIKKKLDENNFITVGLKSKEDKIISIPIEKVNELREICDFLLIEADGAKMLPLKAPDSHEPVILDITNMVVAVCGIDALGKRIKETCHRPNIVARILSKSEEDIVDINDFAYILSSKDGSMKALNEEKMEYRVIINKVDNNKLLKEAIRIAEKIENKSIKVIITSYKYCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZY51</accession>
    <name>A0A173ZY51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ErfK/YbiS/YcfS/YnhG family protein</fullName>
            <ecNumber evidence="6">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ykuD_1</name>
        <name evidence="6" type="ORF">ERS852471_00509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80336">
        <property type="protein sequence ID" value="CUN80336"/>
        <property type="gene ID" value="ERS852471_00509"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017266" evidence="3">
        <location>
            <begin position="25"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="4">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="25415" checksum="29AE3C9C95376180" modified="2016-09-07" version="1">MKNRFITIIVLIVLILNISQISMASTSACTDGNKYIILIDLYARTLTLVDKKTQEEVKVYPIAIGKKSTPSPIGTWQIKSKALMKGPFGGYWLGLNAPWDTFGIHGTSNPSSIGSMASNGCIRMYNHNIKELFNLVDYDTSVVISGGPNWRFSPYDRDITPNCKGADVYHVQRILNALGYYDHPADGIYGYSLELAVQKYKSDHNLQPIDSYIDNNFLKSIGCERFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A016</accession>
    <name>A0A174A016_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263622.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80855">
        <property type="protein sequence ID" value="CUN80855"/>
        <property type="gene ID" value="ERS852471_00516"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017287" evidence="1">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN80855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="308" mass="35838" checksum="086C89A963FFF53A" modified="2016-09-07" version="1">MNKVIKFLLTCMLFIISVESTTFASEENKEMDYIWNTKRDLLVLMLTYPECIKDIEKDEKGFVYLVMQNNNKVLYDDKKEKSHEQKFYNSDLQDTLEQIYPLDMINNVMEEGQDPGRIRCYSFLSNMYGNSKEAVQKNITNKSTYYGSMMFNKVNGAADNLEKALSIISELAKENPKIYNFVSPTSGTFNYRVIQDTGQLSPHAFAIAIDLKSDPADYWKWCNREKGGNRISIYPEEIVKTFEECGFVWGGKWSHFDILHFEYRPEIILKAKYFGECNNAENSEWYEGCTIDENTESLIEKINSVIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5M3</accession>
    <name>A0A174A5M3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum ABC transporter periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ORF">ERS852471_00551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263683.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83463">
        <property type="protein sequence ID" value="CUN83463"/>
        <property type="gene ID" value="ERS852471_00551"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13537">
        <property type="entry name" value="PBP2_YvgL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041879">
        <property type="entry name" value="YvgL-like_PBP2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017410" evidence="4">
        <location>
            <begin position="28"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN83463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="28267" checksum="206E61013BA32B94" modified="2016-09-07" version="1">MKKFSKILSLLLTSSLILSSVGCGSTKKDDTTSVELTVSAAASLKEAMAELEPIFTEKNPNISLTFNFGASGSLQQQIEQGAPCDVFISAGKKQMTALADKDLLETDTNKDLVKNRLVLVSTDNTTVTSLDDLTTDKVKQIAVGEPSSVPAGKYADEVLENLGIKSEVESKLVFAKDVKEVLAWSTSENADVGFVYLSDALSNNSAKIIETISEDLHSPITYPVAVIKDSKNIDAAKTFEDFLFTDEAQQVFEKYGYNKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANE4</accession>
    <name>A0A174ANE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263862.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90092">
        <property type="protein sequence ID" value="CUN90092"/>
        <property type="gene ID" value="ERS852471_00648"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="137"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="32014" checksum="699885175633ABDA" modified="2016-09-07" version="1">MRKTYKYTLLVIGILLVIFAFTDLQISNAIYNSNSSFGMIFEAIGEFPAAVIATFCTVSLMLTRNEEKSVKYNLRTGGYIILLLLFALMAAMLPVKYFNGPTVLIPIIATLYIVISYIIAKKYSSTNREELRNAAIVGVLTFVFVVITFNLVKMGWGRERYRHMIATGSFEGFSLWFIPQKLTTDNEFMSFPSGHSANAAIMIWITLIPTFITSLREKKNWFIGFSLLWILVVPISRIMVGAHFASDVTMGVTITLIIFAILESRYIKKEDIKCEENIGRVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNJ5</accession>
    <name>A0A174BNJ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-exporting P-type ATPase</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Copper-exporting P-type ATPase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cu(+)-exporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">copA_1</name>
        <name evidence="17" type="ORF">ERS852471_00838</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264232.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02612">
        <property type="protein sequence ID" value="CUO02612"/>
        <property type="gene ID" value="ERS852471_00838"/>
    </dbReference>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="808" mass="87030" checksum="FBAC3AD4E53DC90D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BR83</accession>
    <name>A0A174BR83_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264215.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02076">
        <property type="protein sequence ID" value="CUO02076"/>
        <property type="gene ID" value="ERS852471_00828"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO02076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10100" checksum="B2AAC1CFA57A6CFF" modified="2016-09-07" version="1">MINWEVVMWTCITVAVLVGIAAMILLFISAKNLKKRTSEIKEFHIELKPGTKVMFCGGVYGKVVKVGNDTVDVEVAKNVVVTVSRYAIQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3T5</accession>
    <name>A0A174C3T5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NgoFVII restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264330.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06376">
        <property type="protein sequence ID" value="CUO06376"/>
        <property type="gene ID" value="ERS852471_00883"/>
    </dbReference>
    <dbReference type="OrthoDB" id="469688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019065">
        <property type="entry name" value="Res_endonuc_III_NgoFVII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09565">
        <property type="entry name" value="RE_NgoFVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="36176" checksum="F3E7FEC924E864A6" modified="2016-09-07" version="1">MLFNQNLDEIIFNRHQLFESDELIIISGYIGPNPVEKLRNLPLTCTVIYGMYGNSSISPKLHSTLLKLETLSQNTTILYSDIPVHSKCYIWKNKGKIVHALIGSANFSTSGLTIPFRETLAETTQDTFLPLNQYLNQILSNSTPCTEVNLIPNSKTTVNPVTSTNNHTCSMVLYDPRTGEVPTASGLNWCHSSQGHTSIDDGYIPIRTSYIREYPELFPPKQMVATRTNGGKTNRQNDSIELIWDDGTIMEALLEGSQPVDGIIHPKNLSSFPSKNILGSYIRHRLGLPSGSLVTKSDLDRYGRDDIELSLLENGTYYADFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CC74</accession>
    <name>A0A174CC74_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Serine acetyltransferase</fullName>
            <ecNumber evidence="4 10">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysE_1</name>
        <name evidence="11" type="ORF">ERS852471_00959</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4 10"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264477.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10387">
        <property type="protein sequence ID" value="CUO10387"/>
        <property type="gene ID" value="ERS852471_00959"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO10387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="196" mass="21219" checksum="776E05689ABD224C" modified="2016-09-07" version="1">MFKNLSHDLNNIMEKDPAARSKIEVFLLYPCVHALISYRIAHFLYSKKFFFMARLISQLARFFTGIEIHPGAKIGRGLFIDHGMGVVIGETTEIGDNVTVYHGVTLGGTGKDKGKRHPTIGNDVVIGCGAKVLGPITVGDGAKIGANAVVLKDVPTGVTAVGKAAKNLVRVVKSNPEIETEKNNESKKNIYNDMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CE45</accession>
    <name>A0A174CE45_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">ERS852471_00990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer and homodimer (in equilibrium).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264525.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11841">
        <property type="protein sequence ID" value="CUO11841"/>
        <property type="gene ID" value="ERS852471_00990"/>
    </dbReference>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="261"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="411"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="499" mass="55963" checksum="DE52E10E0C90ED12" modified="2016-09-07" version="1">MKKYIVALDQGTTSSRAIIFDKEQNIYGIAQKEFTQIYPKEGWVEHNPMEIWSSQYGVLQEVMAKTNIKPEQIAAIGITNQRETTIVWDKETGEPIYNAIVWQCRRTAKICEELKSQGLDKYIKENTGLVIDAYFSATKIKWILDNIEGSREKAEAGKLLFGTVDTWLLWKLTNGEVHVTDYTNASRTMLYNIKELKWDEKIAKRLEIPMSMLPEVRNSSEVYGYANLGGSKKDIKVPIAGIAGDQQAALFGQACFNKGDAKNTYGTGCFLLMNTGEEMVESKNGLITTIAIGIDNKIQYALEGSVFMGGAIIQWLRDELCLISESSDSEYFAKKVNDNGGVYVVPAFVGLGAPYWDMYARGAILGLTRGANKNHIIRAALESIAYQSKDLIEAMQEDIGLKLKTLKVDGGASKNNLLMQFQADIIDAKVSKPIITETTALGAAYLAGLAVGYWESKEEIAKNFYVSESYEPNFDDEMRRKLYKGWKKAVDRSKKWEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CH58</accession>
    <name>A0A174CH58_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine kinase</fullName>
            <ecNumber evidence="3">2.7.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">udk_2</name>
        <name evidence="3" type="ORF">ERS852471_00998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264531.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12247">
        <property type="protein sequence ID" value="CUO12247"/>
        <property type="gene ID" value="ERS852471_00998"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="285"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="552" mass="63865" checksum="5B0B4EE39958867E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHD7</accession>
    <name>A0A174CHD7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YejK family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264535.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12633">
        <property type="protein sequence ID" value="CUO12633"/>
        <property type="gene ID" value="ERS852471_01003"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1368516at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007358">
        <property type="entry name" value="Nucleoid_associated_NdpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04245">
        <property type="entry name" value="NA37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="346" mass="40046" checksum="222DE3D0D3DA12FF" modified="2016-09-07" version="1">MEYINDINIQEAVIHILDSNSDEPILNEYNLELTEDIYKFLYRHIEKCLKDEELKTAVFNPERNIVKEIVQDYLNGIDKDMITLSRELARQLFVIMKGNVNIPSCDLIVAFLITDQGPLIAILKMDYVKNFTHQVDFVGDKIGIGIVPQAAGLPGSSQRIQKAAFIKPIRDDQRFDLWVIDKQKKSKEDDEYGANYFLNSFLGCTIVANNRDMTKTFLKAAETWTRSNVTEDADKAERIRTTIKSKLKEEDSISIDDISNQLFQEEPKAKEEFATFVKGHGLEDEIAVDKMWVEKKLKRIRLKIDKEIDLYIDEEAYHDPTKFEIQRNGDGSINMIIKHVINYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CU93</accession>
    <name>A0A174CU93_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264589.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16587">
        <property type="protein sequence ID" value="CUO16587"/>
        <property type="gene ID" value="ERS852471_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO16587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="9922" checksum="3C96D77E24C04D15" modified="2016-09-07" version="1">MRNNKIEKIYEVIKANGRALNLHEIKSMTGVGNGYAAQNTIKSSDINNTCITNSYNHKSKKINELLNTAGMKLNLHQIKAMTGAGNGYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUK9</accession>
    <name>A0A174CUK9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrR_1</name>
        <name evidence="5" type="ORF">ERS852471_01032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264568.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15425">
        <property type="protein sequence ID" value="CUO15425"/>
        <property type="gene ID" value="ERS852471_01032"/>
    </dbReference>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="104"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="450" mass="51498" checksum="3D8F73B2E2FBCA8B" modified="2016-09-07" version="1">MEVWGKLDSQETKDSNRRKKRKLSKKKKIIISAFSVLLLLIVFIASGYFYVRSKIYRPTKQIEKPTVTQNTESEETVEYRTVEGITNVLLLGVDGIDFDAADQRSDSMIIATLDSNNKKIKLTSLYRDALVYIPGYGENKMNASFSLGGPELVMETIKYNYDINIEKYVMINFVGFEAIIDQIGGIEIDVQEYQLNELNKYIGEATGGNDCPVEEPGLQTLNGKQALSYARIRKGVGDDYERTERQREVLFKVAEKLQKTKPIKYLGIATKMLDYLRTNIDLYECLDLAYTVFKFPSLVTEQLSIPVPELSEDVKIDGIGWVISMDRYENAEILNDFIFNDYLPDFILNRSTEKDPSIYFEYDGFGSSYDESYYYEEYYYEEDYYTPEIYEPIEEEVIHPEEPSEDIVPPVNESNTGDGTITDDGSNQGEDLGNSDNFDNNQMSPEGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CX48</accession>
    <name>A0A174CX48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+ efflux pump ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhaP</name>
        <name evidence="2" type="ORF">ERS852471_01081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264606.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17804">
        <property type="protein sequence ID" value="CUO17804"/>
        <property type="gene ID" value="ERS852471_01081"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155696at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="429" mass="46761" checksum="A294B7E2847B0187" modified="2016-09-07" version="1">MKKFLNVLSFELTNYFKNKGYMITTILISAILIIGLSLPSLFDLSGLIPGLSKNNATVEENQGGDSGVIDSDSDEENVNYVIFDKSGLIADDNFELIKSYFPNANFEKVTSEEDAEKLVKDGSAKAGFVVESAVKYYYLVENSNFADMSQMTFHSALAAINRKEYAEKEGIDYLELETIVNLPITSETTVLGKDGAGNFGYVYILVFVIYMMTILYGQLVAVSVTSEKSSRAIEVLVTSTSTTSLILGKVIAATLASVIQVGVMLSAGVVTYAINRDAWNGMLDGVLKMPSDILLAFAFFGGVGYLFYCFIFGALGALVSKTEDISSSIGSITMIFVIVFFISMFGMMGNADSLIVKIASFVPFSSSMTMLIRIAMGTVSTIEIIISFVILVLSTITVAWGAIKIYRLATLRYGNPIKLKNALKWLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2I2</accession>
    <name>A0A174D2I2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264636.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19734">
        <property type="protein sequence ID" value="CUO19734"/>
        <property type="gene ID" value="ERS852471_01116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="97" mass="11181" checksum="B4C83F2F05BB624F" modified="2016-09-07" version="1">MRLIDNIYIAEMILMLSSTVINVLFLAGFISDAYVQYGFILVILCGIGINYLLMKEKNNKKEKVVKLRTKKNILSIIIVVVICLSWITTYYLAIFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5H9</accession>
    <name>A0A174D5H9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin reductase</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxB_2</name>
        <name evidence="7" type="ORF">ERS852471_01112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264632.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19529">
        <property type="protein sequence ID" value="CUO19529"/>
        <property type="gene ID" value="ERS852471_01112"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO19529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="34597" checksum="B80551AEDF78673A" modified="2016-09-07" version="1">MTKPIKKKDLIIIGGGPAGLTAAIYAARANLDMLLLEDKILGGQVRNSYTIENYPGFKKISGAELADFMQSQAEEVGAVIDEFDVIERVDFSGEDKIIETGDYIYHADAVIIATGANPKKLPIPNEKKFEGKGVHYCAVCDGAMYKDKVVAVVGGGNAALEEATFLSRFAEKVYIIRRYDYFKGEKATLDDVMNNPKIEVLFNEDLVNVEGSNFVEKAIIRNTKDNTEREIAIEAVFGYIGTEPKTDLVRDFIKMTRTGYIVTDESMMTNIKGVFAAGDVREKEFRQITTAVADGTIAALAAEKYIVDKRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7D8</accession>
    <name>A0A174D7D8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="9">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="9">TH kinase</shortName>
            <shortName evidence="9">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">thiM</name>
        <name evidence="10" type="ORF">ERS852471_01157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264672.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21642">
        <property type="protein sequence ID" value="CUO21642"/>
        <property type="gene ID" value="ERS852471_01157"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1717689at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO21642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="270" mass="29225" checksum="91C230C51F93FEFE" modified="2016-09-07" version="1">MYELINKVKEVNPLVLHYTNEVTINDCANITLAIGASPLMSYSDEEVEEIVSIASAVVINIGTMNSSRLDLFIKAGKAANKYNKPVVLDPVGVFATKTRTDFTNNLLNEIKFDVVKGNIAEIKSIGGLDVRGQGVDSFDDGEDISEVIKKVAKKLDTIVVATGKVDFISDGYRVIKINNGTTKLKSITGTGCMTGSLIGSYLGTFDTLMKLGQVLKDKKVEAVAMGVLTMGLSGELVDVNNIAIGSFKEKLMNNVYELNVDKLKEFGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8J3</accession>
    <name>A0A174D8J3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adiC</name>
        <name evidence="6" type="ORF">ERS852471_01131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264650.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20370">
        <property type="protein sequence ID" value="CUO20370"/>
        <property type="gene ID" value="ERS852471_01131"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="439" mass="47704" checksum="9B38524DF8E049E5" modified="2016-09-07" version="1">MENKNLKKDIGLFMATMLVCGNMIGSGVFMIPATLAEVSGPLATILAWILTTIGSILVAISFANLGSKFPETGGAYQYVKEAFGEFAGFLSAWLYWNGSWIGNTAILVTLTSYSAAIFPVLNKPLYSIIYSSLVLWAVTILNIVGVKQAGKIQSFTTVFKIVFFALFIIIAFLNFDKNNLLPLLPKNKGLETISLAATTTLWAFIGLESATVAAGEIRNPEKNVKRSTIYGLIISAVIYLLISIASMGAMPNEVLAKSTAPLTDILTRYLGNSVGIIISAIVVVSILGTTIGWILATARVAYAAGQDGVFPKIFGKVSSKYNTPVYSLIISGILVNILLLTNYQKSMVSAFSFITILATLSYLPVYLLSVSAEIMIMFRDEKEISIGKFIGKSIIPLLAFIYTLWTIYGSGAETVMWGFILMLLGIPFYIYNYHKNGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJM4</accession>
    <name>A0A174DJM4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264735.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25703">
        <property type="protein sequence ID" value="CUO25703"/>
        <property type="gene ID" value="ERS852471_01216"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="307" mass="35638" checksum="CCD6F29CEC81AFE5" modified="2016-09-07" version="1">MDNILFSVIILSYKNLEYIEDTIKSVIGQDYKDIELIIADDCTDGIDLNKFKKYIDINNNGNIKNVIIYKNKVNLGIVKNINKALSVANGDYIKIIDSDDCFYSKSVLSDVADYFNNNDSIIITTKFLQCDINMKPLVNAENIMDSLKAKLIEGSDSKKFYNKLCAEGTLIDPGVFFKKDFFKQYGMLDESYIHLNDLPLWLRVTRNGCKMDFFDIVSVKYRVGSGISNQDKKDTVLIDDIIRCYNEEIFKYKKQLDYYSYKKARYIYIKSFELNNYSIIKKISFLIGNLDIIFIKIKNKILRSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLP1</accession>
    <name>A0A174DLP1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C11, clostripain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264743.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26117">
        <property type="protein sequence ID" value="CUO26117"/>
        <property type="gene ID" value="ERS852471_01224"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232973at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37835">
        <property type="entry name" value="PTHR37835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="49798" checksum="DF6DEA2775718A85" modified="2016-09-07" version="1">MNIERWTILIYANGNNELEPEITKVIEKLKIENIKENFNILVQLARADEELVEKLRGTIDENHKDRWHGVRRYLLNDNGAHEVEVLENVNMADPTTLYNFLLWGIKNYPSDYVMVVLSGHGAGFIGAMTDFTHGKPYLMSLDGLVNVFYNLYKMTNKKIELLLLDSCYMNLIEVWYEFANIPFKPIKYLLVAPDNVKLEGISYVDFIRYLQEKLGIYKKSKMVLIDVIKEFNEGSKTEDELILVSLEKDKFEKLKNCVNSFVKIINENNIDIEKELQNNLKYEKINPFISVMCLSNIINSRVGYSTNEINKMLEVLKRIVIYPNIEELSKNINTGPVIYMPDSLEQFNEFKQAYTNLLFLSHNNWITILDKNREEVVKESKYIKRYDILPRPIILKRKYVLSSILEQCNDMSVKEAIAIVEMLGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DR69</accession>
    <name>A0A174DR69_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Dihydropteroate synthase</fullName>
            <shortName evidence="8">DHPS</shortName>
            <ecNumber evidence="4 8">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folP</name>
        <name evidence="10" type="ORF">ERS852471_01238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264763.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26759">
        <property type="protein sequence ID" value="CUO26759"/>
        <property type="gene ID" value="ERS852471_01238"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="9">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO26759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="29744" checksum="A2D670254080D018" modified="2016-09-07" version="1">MKIGNKEFNLGERTYIMGILNVTPDSFSDGGKYNEVEEAVKHAKELVDAGADIIDIGGESTRPGALYVTEDEEIERVVPIIKAIKENLDITISIDTYKSKTAEAAIKAGADIINDVWGFKKDKDMAKVAAKYKVPCILMHNREEKPYKNLMEDVLEDLKESINLALEAGVKNENIILDPGIGFAKTYEENLSVMNNVDKLKELGYPVLLGTSRKSMIGLTLNLPVNERVEGTIATTVIGIMKGCEFIRVHDVLENKRAAVMTDKIIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DRA0</accession>
    <name>A0A174DRA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssuC</name>
        <name evidence="7" type="ORF">ERS852471_01267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264817.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28101">
        <property type="protein sequence ID" value="CUO28101"/>
        <property type="gene ID" value="ERS852471_01267"/>
    </dbReference>
    <dbReference type="OrthoDB" id="916788at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO28101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="29562" checksum="E109278457CFDFF8" modified="2016-09-07" version="1">MDREHELYLKKIKRDKIKITIYRITILIVFIALWEVLANFKIIDPFLTSSPSRIVKSFVSFLEQGTIWNHILITCYETIIGFVLGTVLGTIIAVILWCFPTVSKILDPYLVVLNALPKIALAPIVIFWAGNGMSAIIVITLLISIVTTIISVLTGFNEVDKGKMLLMNTFQASKWQKLRYLIFPASIPIFISALKINVGLSWVGVIMGEFLVARSGLGFLIIYGGQIAQLDMVMMSIVILSIIAFVMYKIVAMFEVRVVKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVP5</accession>
    <name>A0A174DVP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-ribazole phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobC_3</name>
        <name evidence="1" type="ORF">ERS852471_01299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.73" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264875.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29621">
        <property type="protein sequence ID" value="CUO29621"/>
        <property type="gene ID" value="ERS852471_01299"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO29621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="22936" checksum="83B5E7B5CEB1D5AE" modified="2016-09-07" version="1">MNIYLVRHGTTKSNEEKRYYGAYDSELSIRGMEEAKILREKLKEIKFDRIYVSSKKRSSETAKIIFGADVKYEVDARLDERNFGIFENKTYDEICKEYSEEVRAWEEDWKNYKIPMGESAMESYLRAEDVLKDIESKKFENILLITHGGFIRNSYCYILNGLDNFWKFSSKNGDISIVKYEYGHWYIDSITHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DX00</accession>
    <name>A0A174DX00_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ORF">ERS852471_01301</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264879.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29737">
        <property type="protein sequence ID" value="CUO29737"/>
        <property type="gene ID" value="ERS852471_01301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1996371at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CUO29737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="27833" checksum="21AE405DD73E6977" modified="2016-09-07" version="1">MKRYFENFLLMLQVLTRIPINKSLPCENTDFKRGANFFAIVGLVIGLIQFIVYSFLIKFFNLDIAVIFVIIIDILITGGFHIDGFGDTCDGFFATKGKDKIIDIMKDSRIGTFACIGIIINILIKFIGYTTILNNITSYIIILLPMISRVSIVLISYIGKAAKEIGSGNLFINTVTFKEVIINYLLFILIAIFMLDIKRLLIIVIISSITTILFNKYCNSKINGITGDSLGANNELVMLILLIVLSGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2A6</accession>
    <name>A0A174E2A6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO32022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264979.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32022">
        <property type="protein sequence ID" value="CUO32022"/>
        <property type="gene ID" value="ERS852471_01357"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="266" mass="30541" checksum="D80B6CB754CAD020" modified="2016-09-07" version="1">MKLLACDLDGTLVETEKNFIRKDNIEAIKKLRKEGHKFIVSTGRDIKGIKSIFKDNKEIEFDYLVLCNGALILDNNFNQIYKNTLPHNVVKSVYDDIYKNNSHKDAAMYVTYENTSSIFYTGCNKEFKDFLGTFENINNEDEVFSKEREYNLISIFSKSSNNDNAEKLKEQLLDTFGESYGIFRNQAFVDMVGKDCSKGSGLKKIIEIENWDANNLYTIGDSYNDISMFNITDNSFTFNHVEDGVKAHANHTVDFVHECIDIILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2E5</accession>
    <name>A0A174E2E5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264899.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30230">
        <property type="protein sequence ID" value="CUO30230"/>
        <property type="gene ID" value="ERS852471_01312"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="423" mass="47087" checksum="ABAC969ECD01B3DD" modified="2016-09-07" version="1">MSHVVGKSAYKSLEERLNRFPQGAPASETLYKILEMLFDKREAELVAQLPIKAFTAEKAANIWGMKVVEATKILDKLASRAILLDIEHEGKRTFLLPPPMAGFLEFSMMRTRGDIDQKLLGELYYQYMNVEEDFIKELFYSADTKLGRVYVQESVLSSENSVEVLDYERASHIIKTATDIGISTCYCRHKMQHVGKACDAPMDICMTFNNTASSLIKHEFARKVDVSECLELLEVAYENNLVQCGENVRKGVNFICNCCGCCCEAMVAAKKFGVMHPVETTNYIANIDKNSCVNCGKCIKACPVGAIKRVTINEGTPMEKVVAKVDEDLCLGCGVCVRNCFKNSICLKSRGKRIITPATSVHRVVLMAIEKGQLANLIFDNRALVSHRAMAAILSSILKLSPVKKAMASEQMKSIYLDKLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4M4</accession>
    <name>A0A174E4M4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31245">
        <property type="protein sequence ID" value="CUO31245"/>
        <property type="gene ID" value="ERS852471_01338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="113" mass="13326" checksum="1E4537C5EA517834" modified="2016-09-07" version="1">MLNTYEQFSILNNELITYLNELISNDIKGTNKEEVISKFDRMLNDIEVLKFKSDEIVETGAGIDQVNNLRYSIMNSLFLISDLLHFYKLDEVERFKMRAVNYINHTAKPQVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E721</accession>
    <name>A0A174E721_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secDF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="10" type="ORF">ERS852471_01359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264983.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32095">
        <property type="protein sequence ID" value="CUO32095"/>
        <property type="gene ID" value="ERS852471_01359"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="417" mass="44710" checksum="5343CB36033853E9" modified="2016-09-07" version="1">MKKGRSATLFILAVIIIISLSFAGFKGVEIGGWEFKSFDKAITKGLDLQGGVSVLMEITDENLSKEDLDNNLEKTKQLLDLRVNKLGVAETTVTVEGDRRIRVDIPGQVDSKEIVESLQKTGNLTFKDSEGNEVLNGKDVEEASVMTDSTTGKPVVSLKLNEEGKQKFAEATEKNLNKTISIYMDEDLISSPVVESVISGGEAVISGSKTIDEAKNLAGLINSGALPVTLKVASIENVGAQLGAEAMPNAMKAGAVGILLIFIFMILNYRMLGVIASIALTLYTTLVLIVFVEANVTLTLPGIAGFLLTIGLAVDANVLIFERIKEEMAKGISAKSAVKSGFHNALTSIIDSNVTTVIAALVLYFMGTGPVKGFAVTLMIGIVLSMFTAIFVTRKLTEWAINMGMLSKPWHFKVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EDC0</accession>
    <name>A0A174EDC0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purN</name>
        <name evidence="5" type="ORF">ERS852471_01374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265013.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33900">
        <property type="protein sequence ID" value="CUO33900"/>
        <property type="gene ID" value="ERS852471_01374"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="204" mass="22454" checksum="756D6D4A5DA842A2" modified="2016-09-07" version="1">MFKIAVLASGGGSNLQSIIDKINDGYINASIDVVIGSKDGIYALERAKKHNIKTCVISKKEFGCETSNRILEVVKDVDLIVLAGYLSILEGEILKVFKNRIINIHPSLIPAFCGDKMYGEYVHKAAIEKGVKYSGCTVHFVNEEVDGGAIILQDIVSVTPDDTYETLQKKILVKEHLNLPKAIKLISEGKIEIVNNKVIIKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELX1</accession>
    <name>A0A174ELX1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yheS_1</name>
        <name evidence="6" type="ORF">ERS852471_01490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265212.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39032">
        <property type="protein sequence ID" value="CUO39032"/>
        <property type="gene ID" value="ERS852471_01490"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO39032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="529" mass="59390" checksum="8036A75AFED22D91" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ERX6</accession>
    <name>A0A174ERX6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="6">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="6">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">psdD</name>
        <name evidence="6" type="synonym">psd</name>
        <name evidence="7" type="ORF">ERS852471_01493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="6">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265218.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39249">
        <property type="protein sequence ID" value="CUO39249"/>
        <property type="gene ID" value="ERS852471_01493"/>
    </dbReference>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023524198" description="Phosphatidylserine decarboxylase beta chain" evidence="6">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023524197" description="Phosphatidylserine decarboxylase alpha chain" evidence="6">
        <location>
            <begin position="256"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="6">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO39249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="34002" checksum="F674DE4043A5E69B" modified="2016-09-07" version="1">MIKIYNRNTQKYDVENVAGGNYIKWCYESPVGKSLTELLIKKKLFSKIYGNYCDTNFSKKKVSSFIKNFDIDMSVCKNNIDDFKNFNDFFIRELKEDARPIDKDKSKLISPGDGRLIAYTDISINDLVQVKNITYSLSELIQDDSIAKEYEGGVCLILRLCPTDYHRFHFIDWGTCEKTHFIPGNYYSVNPTALERVSKLYCQNKREWCVFHSENFGDIIHVEVGATCVGSIIQTYKENTHISKGEEKGYFKFGGSTTILLFKPNTIIVDEDILTQSSLGFETKVNMGETIGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUT1</accession>
    <name>A0A174EUT1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent helicase/nuclease subunit A</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase/nuclease AddA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">addA</name>
        <name evidence="12" type="ORF">ERS852471_01502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -&gt; 5' nuclease activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of AddA and AddB/RexB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. AddA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265232.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39770">
        <property type="protein sequence ID" value="CUO39770"/>
        <property type="gene ID" value="ERS852471_01502"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01451">
        <property type="entry name" value="AddA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014152">
        <property type="entry name" value="DNA_helicase_suAddA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF48">
        <property type="entry name" value="PTHR11070:SF48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02785">
        <property type="entry name" value="addA_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="525"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO39770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1250" mass="144597" checksum="15523C24A68C2642" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ65</accession>
    <name>A0A174EZ65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HesB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265258.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41330">
        <property type="protein sequence ID" value="CUO41330"/>
        <property type="gene ID" value="ERS852471_01513"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010965">
        <property type="entry name" value="HesB-rel_seleno"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01911">
        <property type="entry name" value="HesB_rel_seleno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="110" mass="11899" checksum="54DC22F4DD95D0CB" modified="2016-09-07" version="1">MNKFIISEEAYNEFKAFLQDNEIEKFSIRINLAGFGCSGPAFNITVDDANENDVVETMNDITFIAESKLIDEFGGFKLLSSEENGGRGLSLKPVIEVEGGCGSCGGGCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F096</accession>
    <name>A0A174F096_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA_3</name>
        <name evidence="7" type="ORF">ERS852471_01561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265354.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43762">
        <property type="protein sequence ID" value="CUO43762"/>
        <property type="gene ID" value="ERS852471_01561"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="31984" checksum="FD7BF406F61F574A" modified="2016-09-07" version="1">MKGIILAGGSGTRLYPVTKAMSKQMVPIYDKPMIYYPMSVLMLAGIKDILIISTPRDIVNFKELFRDGSEFGLNIEYAIQEAPNGLAEAFIIGEEFIGNDSVAMILGDNIFYGQNFSSHLKEAAALEIGAQVFGYYVQDPRAFGVVGFDEKGKVTSLEEKPEHPKSKYAVPGLYFYDNSVVEKAKALKPSFRGELEITDLNKVYMEEGSLTVNLLGRGMAWLDTGTHDSMLKASNFVEAVQTTQGTYIACLEEIAYRKGWISKEQVRELAGPLMKTGYGKYLMEVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3X9</accession>
    <name>A0A174F3X9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265406.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45062">
        <property type="protein sequence ID" value="CUO45062"/>
        <property type="gene ID" value="ERS852471_01588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021322" evidence="2">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO45062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="182" mass="20862" checksum="8BC2D7547CE0E06F" modified="2016-09-07" version="1">MNKKVYSKFIVATIVIILCSILETKANADEVLGTIEANNSNISLQNNIEQSNIDLSKLKPGTYEIEYIVTDNDGNRVVQKRKVTILPKDEVVEVDDNSNNYKVTINELFNSGNETEDKDNYLQEDDSYLDTKEKKYVLEKVFSGAYFTEDNKCNNIILILIILIIFILILLIIKKRIFNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8Z2</accession>
    <name>A0A174F8Z2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45139">
        <property type="protein sequence ID" value="CUO45139"/>
        <property type="gene ID" value="ERS852471_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021463" evidence="1">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="161"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO45139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="31797" checksum="BAC6342EA042D918" modified="2016-09-07" version="1">MLFIIVVSKFLCAIYMVTLLSGAGAGSTIESTLEPVTGIRNLTLESKTRYNDSLKVYEGFVEDGTTKASVIIDIPEEVETNTDTRIQNINGINDAYRLFEMIDNLKLSISDRDNSFKELYASKDVKREITYNPNNLREKSNLSIEQIYNLLEGSKLQVLASSYYEMENKHNVNAIFLMALNIEESGHGTSDLAVLNNNIGGVKSASGGWETFDDWNHSLEYIASLIDEMYLSEDGAYYNGSSIYDVNIRYCEGNQWAFNINTIAMELLERANSIKDNYIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FB45</accession>
    <name>A0A174FB45_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">manB</name>
        <name evidence="11" type="ORF">ERS852471_01612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265449.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46036">
        <property type="protein sequence ID" value="CUO46036"/>
        <property type="gene ID" value="ERS852471_01612"/>
    </dbReference>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="42"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="206"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="322"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="478"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO46036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="565" mass="63349" checksum="9B7198B3E355CC99" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FP41</accession>
    <name>A0A174FP41_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpF</name>
        <name evidence="14" type="ORF">ERS852471_01715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265635.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52032">
        <property type="protein sequence ID" value="CUO52032"/>
        <property type="gene ID" value="ERS852471_01715"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO52032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="159" mass="18839" checksum="7AC84B7A4BE42779" modified="2016-09-07" version="1">MEINIGVILASIVNTAILYMILKHFFFDKVKAVINEREEYINKTFLEAEEATEKARTISIESEKRIEKLKRKSRKITEDEKRKAENIYKDIIDEAKKEAEIIKEKARVEIEREKKRNEYVLKERYVNLAMELSEQLIEKNIDEGKNKELIDEFISKVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FS74</accession>
    <name>A0A174FS74_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">upp</name>
        <name evidence="12" type="ORF">ERS852471_01721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265645.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52337">
        <property type="protein sequence ID" value="CUO52337"/>
        <property type="gene ID" value="ERS852471_01721"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO52337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="23104" checksum="0655E99E68D05EEE" modified="2016-09-07" version="1">MSKVTEMKHPLISHKLAYIRSKDTGSKYFRELVEEVSMLMAYEVTRDLETEDVEIETPICKTTCQMLAGKKMAIVPILRAGLGMVDGILNLIPAAKVGHIGLYRDEETLQPVEYFCKLPQDIAERDVIVVDPMLATGGSAADAIMLLKQRGAKKIRLMCLISSPEGIELVQKQHPDVDIYVAAIDEKLNEKGYIVPGLGDAGDRLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSM1</accession>
    <name>A0A174FSM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation peptidase YabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265683.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53282">
        <property type="protein sequence ID" value="CUO53282"/>
        <property type="gene ID" value="ERS852471_01742"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1185419at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008764">
        <property type="entry name" value="Peptidase_U57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05582">
        <property type="entry name" value="Peptidase_U57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011575">
        <property type="entry name" value="YabG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02855">
        <property type="entry name" value="spore_yabG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="32757" checksum="9C83B3060E5C711A" modified="2016-09-07" version="1">MQIGDIVVRKSYDKDITFKIIDIKEEKGQAIYILKGISIRIIADSSVDDLEQVDSAFIGTKEKILNTRVNEAINKAIGLRGDLAAREAIMSRGSKSQKQNPNKELMFGRPGKILHIDGDKDYLETCLKVYKQLSLDAVGRAIPEKEQWNCVVDLVKEIKPDIVVLTGHDSVLKKTDDFLDLDNYRNSRYYIDAVKALRNYNSSYDELVIFAGACQSCYECLLDAGANFASSPSRVLIHCLDPVFVCEKIAYSRIDTVVSITDVIDSTITGIRGIGGLQTRGKYREGYPRSPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FVQ0</accession>
    <name>A0A174FVQ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265692.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53547">
        <property type="protein sequence ID" value="CUO53547"/>
        <property type="gene ID" value="ERS852471_01746"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1202022at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="244" mass="28997" checksum="FBD0CE01FEBFE322" modified="2016-09-07" version="1">MDIITYLNNNKVIVDENLTRKSDRNSIDISSQLDLIVMIQSRLMNNKITIIPRINSTIGKDVENFRVQIKKVDKLLNTINLKNNKNEFDFYLLEKGNIALNRAKTSFDVMDNESYFDLIRRSMNNYEMCLGRVDEGNLKLAENEILKIRTTKYISYNLIEHDLFNYIKRIKRRNFNIQIEKVIDEFVYKSSLSEKSKNYLTALCNYPFETMKLIYKYRGYDDNDYDDWIKKINMAIEIDGDEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4Y8</accession>
    <name>A0A174G4Y8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dacC</name>
        <name evidence="17" type="ORF">ERS852471_01797</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265792.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57051">
        <property type="protein sequence ID" value="CUO57051"/>
        <property type="gene ID" value="ERS852471_01797"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1499212at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022259" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="16">
        <location>
            <begin position="299"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO57051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="407" mass="45007" checksum="D87CAF989F26CD3E" modified="2016-09-07" version="1">MNKNFIKIISFVLLCLLSLSNITVSASLNGENLEEEFYDEITTNSVYEEGNIVVEARSALLMEPISGTILYEKNIDEKFAPASVTKIMTMLLAMEAVDSGKISLQDKITCSENAKKMGGSTMLLDTGEVRTVEEILKGIAIASGNDAAVAMAEFLGGTEEAFVEMMNKRAQELGMTNTTFKNCNGLPVEGHLSTARDIATMSMELLKHKGILKYTGTYMETISEGRKTPIELVNHNKLVRFFNGCDGLKTGFTDEAKYCISATAVHDGVRMLSIIMGAPTYKVRNRDASMLLNYGFSKFEGKKIFDKDADVEKIYLGKNTDRFFIAKSQDDLVIVVPKGTDGEPTTKVVLDELKDSYTMGEVVGKCEVYMGENKVGEGLLYADRDVEKANFLDNFKYNMKNLFKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G731</accession>
    <name>A0A174G731_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor P</fullName>
            <shortName evidence="8">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">efp</name>
        <name evidence="12" type="ORF">ERS852471_01825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265846.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58292">
        <property type="protein sequence ID" value="CUO58292"/>
        <property type="gene ID" value="ERS852471_01825"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="11">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="10">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="20838" checksum="D0C7F52C648FA5DC" modified="2016-09-07" version="1">MISAGDLRKGTTFEYEGQVFTVIDFLHVKPGKGAAFVRTKLRNVISGGVTDTTFNPTAKLQEAVIERKEMQYLYSDGELYYFMDQETYEQIPLNYEKVEDAIKFLKENMFAIIKFYKGDAFSVEAPNFVELLITQADPGIKGNTATNAMKPAILETGAVVNVPMFVNEGDTIRVDTRTGEYMERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8Y4</accession>
    <name>A0A174G8Y4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">spo0A</name>
        <name evidence="12" type="ORF">ERS852471_01803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8 9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265804.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57329">
        <property type="protein sequence ID" value="CUO57329"/>
        <property type="gene ID" value="ERS852471_01803"/>
    </dbReference>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012052">
        <property type="entry name" value="Spore_0_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002937">
        <property type="entry name" value="Res_reg_Spo0A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02875">
        <property type="entry name" value="spore_0_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 8" id="KW-0749">Sporulation</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO57329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="30104" checksum="4280AEADBDE1FD99" modified="2016-09-07" version="1">MESNKISVLIADDNKEFCSILNDYLLNQRDIVVTGIAKDGKEDLALIEQKEPDLVVLDIIMPHLDGLGVLERLHSMNLKKFPRIIVLSAVGQDKITQRAITLGADYYVVKPFDMDIFTKRIREMFNGVVTTEVIKKPISVPVNEVVSSNGPMDLETEITNIIHEIGVPAHIKGYMYLREAITMVVNDMELLSAVTKELYPSIAKKYNTTASRVERAIRHAIEVAWGRGQIEAINKLFGYTVHNDKGKPTNSEFIAIIADKLRLKNKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GAF6</accession>
    <name>A0A174GAF6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="8">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">murE</name>
        <name evidence="13" type="ORF">ERS852471_01851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265896.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59454">
        <property type="protein sequence ID" value="CUO59454"/>
        <property type="gene ID" value="ERS852471_01851"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="111"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="326"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="8">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="8">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="8">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO59454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="481" mass="53967" checksum="D1B0813AEFBF80F5" modified="2016-09-07" version="1">MKLLQLLDGVNYKVVKGTLDKEIVNIQYDSRKVTNNDIFVCLSGFEVDGHNFANKAIENGARVIICEKDIELVNESNDVTIIKVDEGRKTLATMAANYYDHPTKKLKLIGVTGTNGKTTSVYILKSILEKSGEKVGLIGTIANYIGDEKIESTHTTPESLELQKLFKNMVDKGCKYCVMEVSSHSLALDRVYGCHFDIGIFTNITRDHLDFHKTFENYYDAKFKLFERSDYSIINVDNNYGYNVIRDLEKLNKKAITYSISEESDYRATEVEFIGQDTIFTVNGTRYEFVLPGEYNVHNALGCIAAAKTLGISEENIKSGLLDVVVPGRCERVGIKYNLPYELIIDFAHTPDGLKNLLETLRILTKNRLIAVYGSGGDRDKVKRAEMGRIGSEIADLVIITSDNPRTEDPIAILKEISCNIQKTNYLAIEDRVEAIRLAMDMAEPGDVVVLAGKGHETYQIMPEGKVHFDEREVIADILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GB12</accession>
    <name>A0A174GB12_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265838.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58079">
        <property type="protein sequence ID" value="CUO58079"/>
        <property type="gene ID" value="ERS852471_01820"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696273at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014211">
        <property type="entry name" value="Spore_III_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02849">
        <property type="entry name" value="spore_III_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="127" mass="13653" checksum="AA2B50C153E20A77" modified="2016-09-07" version="1">MEIIKVVSFALAALFIFMLLGERKKELAVLVAIIAGAIIFLALIDKLSEIINFINTIADKANIDMVYIGIVLKILAIAYLSTFCSEICKDAGATSIASKVEFAGKILILALAIPILMAVLNSILQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GL41</accession>
    <name>A0A174GL41_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266014.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63073">
        <property type="protein sequence ID" value="CUO63073"/>
        <property type="gene ID" value="ERS852471_01920"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="47"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO63073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="441" mass="50617" checksum="4771F684D9B4497C" modified="2016-09-07" version="1">MKNIKNFYLPLFFSTIIIIIYMFFTPYTQYTSKLSFTDNINTTDELTFYISSDIHYLSKSLTDYGIAFNRFNKNGDGKQLEFICEIFNEFANEIKNRKPDFLILSGDLTLNGEKQSHLDLSSKLAEIKASGVDVYIIPGNHDINNPNARGFKEENQYKTDFVSKEEFINIYQDFGFNDAISKDKSSLSYLVAPSNKLYILMLDDNLYNNNLSINYPEVNGCISKDTLNWINNCGKLAKNNNAKIIAVSHHNIINHSNYIYSGFTLDNSDEVLNTLKNNNIHLCFTGHIHFQSIKSTSLDNSILTDIASSSLAIYPQQYGIATFNKDKSLSYEIATLNMDNFDPSFKSNSKKSFKNFVYNQNFKRLSYSDDYTEEELKAMCETLSNIRLKYNDDSEEISWDSIISSKGFNLLKSCPSPFIKHYVDIALNNKDNNYKNLTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQ64</accession>
    <name>A0A174GQ64_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO62999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266010.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62999">
        <property type="protein sequence ID" value="CUO62999"/>
        <property type="gene ID" value="ERS852471_01918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO62999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="7189" checksum="9B4312D76FEFAC16" modified="2016-09-07" version="1">MGKVIDITDILALRKAVRILELLDKDYDYDVLKAHPNICREIIVLFGKELDKPENSKNEYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2B9</accession>
    <name>A0A174H2B9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">deoD_2</name>
        <name evidence="2" type="ORF">ERS852471_02014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266199.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67456">
        <property type="protein sequence ID" value="CUO67456"/>
        <property type="gene ID" value="ERS852471_02014"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="26684" checksum="EC57340250768ED5" modified="2016-09-07" version="1">MGTIHIEANREDIAKIVLMPGDPLRAQFIAENYLEDAVQINKVRNMFGFTGYYKGVRVTIMASGMGGPSMGIYSHELFNKYDVEAIIRIGSTGAYSEKLNMHDVMLVESSWSQSTYAKTYSGYEEDVVYPNNELNTLIKEVSNKLNINIKTGRIHSTDAFYTKDKSVLHHIRDTYGCLGVEMESFALLHNANVAGKKAACLLTVADHALTNEKATVEERQHAFENMINLALGTVVEYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8T0</accession>
    <name>A0A174H8T0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clostripain family protease</fullName>
            <ecNumber evidence="2">3.4.22.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cloSI</name>
        <name evidence="2" type="ORF">ERS852471_02075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.22.8" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266302.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69746">
        <property type="protein sequence ID" value="CUO69746"/>
        <property type="gene ID" value="ERS852471_02075"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232973at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37835">
        <property type="entry name" value="PTHR37835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="458" mass="52350" checksum="8F8CDBC0318FE924" modified="2016-09-07" version="1">MKKIYRYIEIIVISILTVFMFTMCTNSKSTSEENAVVQIEDDVNEINEIVEAEESVVENLKRDYRTNIKGNNEDVVTLMIYMCGSDLESEYGTASVDINEILSADISENVNVLIQTGGCVDWTNDQISEERSQIFSVENGELQLVNDDLGLKNMAESSTLTEFINYSKESYPANRYGLIIWNHGFGTLEGFGHDENFENDNMDVYSLAKALDDSNTYFDFIGFDACFMSTVEVAYTLEPFADYLIASAEIEPFAGWYYTNWLNQLSNNTSIDTVELGKIIIDDFVEHNSRREVPENAVLSITDLTEIRVTYNEICKLLSEINEELENGSFEKISLIRSEVEAYAENLTDHVDILRLAEMINLNSSQKVIDAINNLVKYTGKTTTMAEVGGLSLYFPYYKMNYFSKFQDNFESLNLNKEHFEFVNNITNVIKEGKMEVIGEARKFEEDKEAEINRYNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDS3</accession>
    <name>A0A174HDS3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome C-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">resA</name>
        <name evidence="11" type="ORF">ERS852471_02108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266369.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71486">
        <property type="protein sequence ID" value="CUO71486"/>
        <property type="gene ID" value="ERS852471_02108"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="252"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO71486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="396" mass="44481" checksum="9A8DFB4A235714B9" modified="2016-09-07" version="1">MGNINIFIVFIEGILSIFSPCILPILPIYLSMLANSTVSDMNDSKFKSSILIRNTLFFTLGISTTFFILGASINALGSLFSTYKYIIMIIGGIIILIMGLFYLGVIKSEFLSREKRLSVKYKTMSPLAAFVLGFTFSFGWTPCIGPILASVLVMASTADNILVANLLILVYTLGFILPFLIVAIFYSKLGKYLNKVKKHMETIKKISGILIILAGLIMLVNGFVDVNKQLNSKDESNIENNNYSTEENAGEEEERLAPIDFTLYDNYGNKHTLSEYKGKTVFLNFWATWCPPCREEMPYIDELYEEYNKNQEDVIILGVASPNLGREGSQENITEFLESNGYKFPVVFDENGSLMYGYGMNSLPSTLIIDKDGYITTYVPGAMNKETMKKVIERDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZY3</accession>
    <name>A0A174HZY3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78678">
        <property type="protein sequence ID" value="CUO78678"/>
        <property type="gene ID" value="ERS852471_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO78678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="57" mass="6210" checksum="9389CFE685411664" modified="2016-09-07" version="1">MAAGNGVNCAYCPELKKGTCDGKGDGCVCYKCPRHLGQCICVKYCRETESVLIFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2D5</accession>
    <name>A0A174I2D5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ORF">ERS852471_02356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266782.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80611">
        <property type="protein sequence ID" value="CUO80611"/>
        <property type="gene ID" value="ERS852471_02356"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="95" mass="11073" checksum="49C8ECF59EA44FFA" modified="2016-09-07" version="1">MRKYETIFILHPSFDEEAVKANIEKFKGVIENGGGTIENVDFWGKRKLAYEIKKVNEGFYTLINFEANPELPSELDRIFRITDGVIRHIIVKQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I331</accession>
    <name>A0A174I331_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Preprotein translocase subunit SecA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA_3</name>
        <name evidence="1" type="ORF">ERS852471_02326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266739.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79720">
        <property type="protein sequence ID" value="CUO79720"/>
        <property type="gene ID" value="ERS852471_02326"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1438224at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="165" mass="19312" checksum="A0C2CDC56E6AAAF6" modified="2016-09-07" version="1">MSLYKQWTDMVVEYVKTKGENAFWAEYTKIESRIYKDLLAKHTEVQTITIAEFAKKYDTTEEFIMGFVDGINESLKTVYDLENLTANDEIALDIDLEKLYFNMLEAKAEYLYNLPQWDAIFSEEKRKEIQKAYRESTMVRNENKVGRNDACPCGSGKKYKKCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4W1</accession>
    <name>A0A174I4W1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82232">
        <property type="protein sequence ID" value="CUO82232"/>
        <property type="gene ID" value="ERS852471_02385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="52" mass="5709" checksum="99610FD5934E9DF2" modified="2016-09-07" version="1">MKDNIKVVVNEVGGECITSVGYKTIARGVLKALGKDICKLLVNEFNNKDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I521</accession>
    <name>A0A174I521_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein insertase, YidC/Oxa1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">misCB</name>
        <name evidence="8" type="ORF">ERS852471_02370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266808.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81126">
        <property type="protein sequence ID" value="CUO81126"/>
        <property type="gene ID" value="ERS852471_02370"/>
    </dbReference>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO81126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="28412" checksum="A50471DE34E68991" modified="2016-09-07" version="1">MWDAIVNAMVNMFNGLHNFIVSLGVPAEREGLSYILAILIFTVIIRLLILPLNIKSTRSNARMQEIQPEMKKLQAKYKNDPQKLQLETSKLMKENNVSMFGGCLPTLLPLPILFALYRVFYSITPTQGADLSFLWINNVFQPSGFNMTGILLAILAALSTYIPSLLLSKSMPTPEEGGMNMSTMNIMMAGMMGFMSINFQPILVMYWIAGGVIQLVQTYFLNYLPAMKKKKAKEAAALASKPNKTTITTKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IEH3</accession>
    <name>A0A174IEH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inhibitor of sigma-G Gin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266970.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85563">
        <property type="protein sequence ID" value="CUO85563"/>
        <property type="gene ID" value="ERS852471_02461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019700">
        <property type="entry name" value="Sigma-G_inhibitor_Gin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10764">
        <property type="entry name" value="Gin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7545" checksum="0E12EAFE84A4D827" modified="2016-09-07" version="1">MINNKEIILKKKRHCKICGKARYDGIMIIKSFICEDCVNSITNEEFDDKQYEDMKNRIKDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174II44</accession>
    <name>A0A174II44_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplB</name>
        <name evidence="8" type="ORF">ERS852471_02496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267036.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86952">
        <property type="protein sequence ID" value="CUO86952"/>
        <property type="gene ID" value="ERS852471_02496"/>
    </dbReference>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="7">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO86952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="30488" checksum="9D4E24AB5B2F7C0C" modified="2016-09-07" version="1">MAVKKFRPTTPSRREMTMATFEEITTNSPEKSLLVSLKKTGGRNAQGKITVRHHGGGAKRKYRIIDFKRNKDGIPARVATIEYDPNRTAYIALVVYADGEKRYILAPVGLKVGDTVVSGPEADIKPGNCLQLKHMPVGTVIHNIELQAGKGGQMVRSAGTSAQLMAKEGDYATLRLPSGEMRYVRIECRATIGTVSNTTNDIINIGKAGRKRHMGWRPTVRGSVMNPCDHPHGGGEGRSPIGRPSPVTPWGKPALGYKTRKNKKYSDRFIIKRRNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IKB0</accession>
    <name>A0A174IKB0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplC</name>
        <name evidence="8" type="ORF">ERS852471_02493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267033.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86841">
        <property type="protein sequence ID" value="CUO86841"/>
        <property type="gene ID" value="ERS852471_02493"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="22569" checksum="DDFA7152A8730DE8" modified="2016-09-07" version="1">MKKAIIGKKIGMTQIFDENGKVVPVTVVEAGPCVVVQKKTIEKDGYEAIQVGFGEIREKLVNKPVKGHFAKAGVSLRRTLKEFRLDNANEYEVGQEIKADIFTAGEKVDVSGVSKGKGFQGVIKRWNANRGPMSHGSKFHRAVGSMGASSDPSKTFKNKQMPGHMGAVNTTVMNLEVVRVIPEKNLILVKGGIPGANKSTVVIRNAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IMC7</accession>
    <name>A0A174IMC7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86085">
        <property type="protein sequence ID" value="CUO86085"/>
        <property type="gene ID" value="ERS852471_02473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO86085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="53" mass="6205" checksum="0DDDA3FF7CBE990A" modified="2016-09-07" version="1">MFSKSYYDNINGKNILTDYRPKDMSNDYLDNFTDSSLENMVINSNLDNSNMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174INS9</accession>
    <name>A0A174INS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetracycline resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267025.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86625">
        <property type="protein sequence ID" value="CUO86625"/>
        <property type="gene ID" value="ERS852471_02486"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO86625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="169" mass="19709" checksum="7EC6758CE37BE246" modified="2016-09-07" version="1">MKIIFVDGYNVINSWSNLKREKEISLDSARQKLVDILHNYGAINRCKIVIVYDGHRVTGNIENKYEHNKNLLVVFTKDRETADAYIEREVHNLGRRFEVYVVTSDSLEQQTIFQRGAVRISSIEFYNLVRVDIENVKKNSKKVHVSAKNTLEDNLDEDVLKKLEAIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J157</accession>
    <name>A0A174J157_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S58 DmpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267168.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90809">
        <property type="protein sequence ID" value="CUO90809"/>
        <property type="gene ID" value="ERS852471_02578"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="34024" checksum="BBA91CA5AC1176F9" modified="2016-09-07" version="1">MKEINIADIDGIRIGHAEDKIGATGCTVLICEEGASAGVDVRGGAPGTRETDLLDPVQMVQKAHAVVLSGGSAFGLDAAAGVMEYLEERNVGHDVSITKVPIVCQAVIFDLICGDMKCRPNKEMGLKACIDSEKYNENVNGNIGAGTGAVVGKFKGPQFAMKGGLGMYAVQVGDLKIGAVVSVNCLGDVINYENGEIIAGALNEDMKTFANTEKMMIGMYDVKKDAFNGNTTIGVVVTNADLTKAEANKVASMTHNAYGRTMRPAHTMFDGDTIFTMATGKVKCDVNVAGLLATKVMEEAIMRAIKSANSEYGFVSYKELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J5D4</accession>
    <name>A0A174J5D4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TDP-fucosamine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267231.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92299">
        <property type="protein sequence ID" value="CUO92299"/>
        <property type="gene ID" value="ERS852471_02617"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1555829at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO92299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="31234" checksum="97DFD06ED131DB6F" modified="2016-09-07" version="1">MREECFNKIKEAVNKFKYSSMRYIEYKDIHDYEVCLENANIILIYGFNVEANINEYHWAANNVEDLINVLKNKKDFLITFIPNEWIFRLEEAEFIVRNAWHDYFMNNLNDIDICDDFDFLTVDRCDEASKVTMMCKNQSRGFTGQTTKWVEEWINNTETSGVNTGTRNNAVLIQKNEEDEIIGIVCVATYGHESKKGPTVWIREVAVNPSYQNKGIGRRLIMKALSYGKKYGATRAFLAADECNDRGIHLYTSIGFEASEDESQIDMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6A4</accession>
    <name>A0A174J6A4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267261.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93168">
        <property type="protein sequence ID" value="CUO93168"/>
        <property type="gene ID" value="ERS852471_02632"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO93168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="127" mass="14849" checksum="F4CADB878CDE6628" modified="2016-09-07" version="1">MLLKIDFDSDIPIYNQIKTEIIKGIARGEIEEGEILPSVRGLASDIEVNMHTVNKTYSILKDEGYIKIDRRKGAFISLNLDESNNKFRRSFEEELEYYIAECCNRGISKDEVYKIIEKKYSLFKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J829</accession>
    <name>A0A174J829_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267267.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93280">
        <property type="protein sequence ID" value="CUO93280"/>
        <property type="gene ID" value="ERS852471_02635"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO93280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="417" mass="48370" checksum="60D5CBDDD19F905E" modified="2016-09-07" version="1">MRDRFIEKISIFNDSFRAKINKFMNLSIEKRITIISMLILILSIFVMISMSSGISTKEEVISNFKTAIENKDVKLLSKTLKVDNKRVNYENLIPIMNYYHDKMDTLLDVTKKLRADNKSGMLQIESKKNILAEEYYLNINKVSVEVKSNFNDTEVTIDNKTIKSGEILENIIPGNYVASYKLKTDFGFVTGENEVTITDQDVINISVDAGNITIYSDYKDADVFIGNKNIGKKVESVVNFGPIPLNRDISIYIEKEFPWGKIKSETLYINDSGIIKLNIDMVNEKLMSDIDILLNDFFDSVFNALNEEDESLIINANEDTKDKIYDDIFKKTLFFTNNYRISDMNLNIEKSDFEYEDEIYKGNVVVKVNYDIYKKLLPFIKESHEEMFLVNLQYENDTWIACGIQRFNLYEEDNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JAK8</accession>
    <name>A0A174JAK8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ntpF</name>
        <name evidence="4" type="synonym">atpF</name>
        <name evidence="5" type="ORF">ERS852471_02674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94947">
        <property type="protein sequence ID" value="CUO94947"/>
        <property type="gene ID" value="ERS852471_02674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO94947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="11539" checksum="BDA7452D6A9DC992" modified="2016-09-07" version="1">MIVMYKKIGVVGDKDSVLAFKALGIDVFPVVDADEARIAVDKMAMNDYAVIFITEQVAVTIEETIERYNKQVLPAVILIPSNQGTLNIGSKRISDSVEKAVGVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBH4</accession>
    <name>A0A174JBH4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">dnaK</name>
        <name evidence="13" type="ORF">ERS852471_02715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267415.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97044">
        <property type="protein sequence ID" value="CUO97044"/>
        <property type="gene ID" value="ERS852471_02715"/>
    </dbReference>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO97044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="617" mass="66081" checksum="F0325AD0ECBAD075" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JH53</accession>
    <name>A0A174JH53_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267490.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99064">
        <property type="protein sequence ID" value="CUO99064"/>
        <property type="gene ID" value="ERS852471_02758"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="435"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO99064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="534" mass="62285" checksum="723C3F11650BB06B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JHZ0</accession>
    <name>A0A174JHZ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator MalR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cytR</name>
        <name evidence="5" type="ORF">ERS852471_02765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99344">
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        <property type="gene ID" value="ERS852471_02765"/>
    </dbReference>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
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        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO99344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="37571" checksum="74433E142BAD9E0D" modified="2016-09-07" version="1">MNIRDIAKLSGVGVSTVSRVLNNHPDVKESTREKVMQIIKESNYIPNNSARILKQNNTKNIGVLIKGVFNPFFSEMLNVIGSKINESKYTMILQQNDYGLEEDVDTLKYFIKEKRLQGVICLGGNFVDIDEESFRNIDVPVVLTSVNTVIPNIEDKYSTVGIDNLKSAYDATNYLIKLGHKNIAIMLGEKNDLCISWWRYKGYKKALEESNIDVDTENMLIGNYDTRTAYNEAKRFLQQHNGVTAIFAISDIMAVGAAKAAADCGLVVGKDIAIMGFDGMDISEFYNPGITTMKQPKEEMALKSVELLFALLSGKGEHRQILLDTELIERESCSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPB0</accession>
    <name>A0A174JPB0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267528.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00006">
        <property type="protein sequence ID" value="CUP00006"/>
        <property type="gene ID" value="ERS852471_02780"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="210" mass="23761" checksum="4D25B5486DDE14F3" modified="2016-09-07" version="1">MKLLFFDTETTSVKPGNICQLSYITVDTSTKPQTTIGKNFFFTVDEMDEGAEAIHGFSLEKLYELSDGLEFFDQIQEFMKDFFDADFVIGHNVQFDVKFLKHEVDSLYQAGMIDTNWEPKRTFCTMAYYKPICNIPSANGNGIKNPKLSEVINFLGISDETIAAKADELFQGSGNYHDARFDTAAVYLLVIEGMKKKLIKPGFFSNQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JRP9</accession>
    <name>A0A174JRP9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">divJ</name>
        <name evidence="8" type="ORF">ERS852471_02801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00876">
        <property type="protein sequence ID" value="CUP00876"/>
        <property type="gene ID" value="ERS852471_02801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="405"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP00876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="656" mass="76803" checksum="289CD6F971EAD409" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JVL3</accession>
    <name>A0A174JVL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavocytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ifcA_4</name>
        <name evidence="6" type="ORF">ERS852471_02813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267598.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01817">
        <property type="protein sequence ID" value="CUP01817"/>
        <property type="gene ID" value="ERS852471_02813"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025499" evidence="4">
        <location>
            <begin position="25"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP01817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="556" mass="59766" checksum="C5A7E069FCCD6D3D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JY75</accession>
    <name>A0A174JY75_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrI</name>
        <name evidence="9" type="ORF">ERS852471_02872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267706.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04702">
        <property type="protein sequence ID" value="CUP04702"/>
        <property type="gene ID" value="ERS852471_02872"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1657328at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="7">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="8">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP04702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="16061" checksum="29D1C2C485001757" modified="2016-09-07" version="1">MLEITSIKNGFVLDHIRAGVGVKIFKYLKLEDGENEVALIINAKSIKNGRKDIIKIENATEIDFTVLALLSPGITINQVKNEEIIAKIKPELPKQIKGIITCNNPRCITSDEKYLEHVFDLVNEDKGSYKCQYCDTIINPSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K4X1</accession>
    <name>A0A174K4X1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C_GCAxxG_C_C family probable redox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267726.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05107">
        <property type="protein sequence ID" value="CUP05107"/>
        <property type="gene ID" value="ERS852471_02883"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2083729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP05107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="14912" checksum="3C243D92E6131C19" modified="2016-09-07" version="1">MGERKNKAIELHSNRYTCSQAVACAFCDLVDVDDETMKSIVRKYSGGTYKVCGAVMGAYVIVNYLKGNINPDNPAEWIKEDEELLHEIERRFKEKNTSVMCKDLKGITTGNVLRSCRGCVEDAAEILEELLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KCR0</accession>
    <name>A0A174KCR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267868.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08621">
        <property type="protein sequence ID" value="CUP08621"/>
        <property type="gene ID" value="ERS852471_02964"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="94"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="35452" checksum="872BBB84E09D645A" modified="2016-09-07" version="1">MGTFESLSKAYESAKVIPYDCNSKFVMMSDCHRGIGNWGDNFISNQHLFWAALNYYYEGGFTYIEVGDGDELWENRSMKEIVKIHSNSFWLMSKFYNENRLYMIYGNHDIEKKNEKLFNRNCSEYYCETRKKVCPLFPSMQVYEGLILEDSNNSNRIFIVHGHQGEFINDIAWKLGRFLVRYLWRPLELWGVKDPTRAGENYKRKDKIEQHLIKWAEEENKMLIAGHTHRPSFPKVGEVMYFNDGSCVHPRCITAIEIEKGSISLVKWSMMTREDRTLYVEREVLEGAVKIDDFFKAREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKQ5</accession>
    <name>A0A174KKQ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOL1/NOP2/sun family RNA methylase</fullName>
            <ecNumber evidence="7">2.1.1.178</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmF</name>
        <name evidence="7" type="ORF">ERS852471_03027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.178" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11401">
        <property type="protein sequence ID" value="CUP11401"/>
        <property type="gene ID" value="ERS852471_03027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="34"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="126"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="318" mass="36976" checksum="346CB1E9A9CC6078" modified="2016-09-07" version="1">MAINIGIKGLRGLFPEYYLDMLYEIYTPKEVDLILKSYLVGRRTTFRINRLKKGSDKTLEELKRKNIKVDKSTCFKDVYILKEKQERLLQRLESYRKGYIYMQNLSSIMPAEILDVNEKDKVLDMCAAPGGKTLKLSEKMNNKGEIIANEVNKIRYERLNFNIEKHGANNVTTLNLDGRKLMNIYKEYFDKILLDVPCSGEGTINIKNTKKLKLLKNGPFIKVQRELIQSAFATLKRGGVMMYSTCTISPQENEEVVNYLLKKNKDADILPININIPNYKKGAIFYKDKVYDERISRSIRIIPNEFMEGFYLCLICKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQ98</accession>
    <name>A0A174KQ98_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268047.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12971">
        <property type="protein sequence ID" value="CUP12971"/>
        <property type="gene ID" value="ERS852471_03053"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1776527at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dak1_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="83" mass="9449" checksum="EF7888025B74D6E5" modified="2016-09-07" version="1">MIEYKFDTQLLIEGNNLSEDEINDYITANIEGDCLLAVGDDELIKIHFHTNTPWKLLEYCASLGEIFDVVVENMERQAKGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L3V0</accession>
    <name>A0A174L3V0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268250.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18922">
        <property type="protein sequence ID" value="CUP18922"/>
        <property type="gene ID" value="ERS852471_03169"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2164663at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP18922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="179" mass="19997" checksum="B35F40450EAE1344" modified="2016-09-07" version="1">MSEMVIGKKTGVAALRARRPAPKLRPKNKEDNKMVSSNNELVEDDYEIKESIDLDSFKPSESKSINKGIAEAGVMSIINSKTGKRIIVSNEIMEKLNKPERIVMSFSGDKIAIGEQLPNNDNYINIKVLKSKGVIYSAGIVKEITDLYKLDFSNKTSITFFDVEYVKYEDNVVAIITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6C7</accession>
    <name>A0A174L6C7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cotSA_2</name>
        <name evidence="2" type="ORF">ERS852471_03138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268198.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17345">
        <property type="protein sequence ID" value="CUP17345"/>
        <property type="gene ID" value="ERS852471_03138"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="400" mass="46298" checksum="34FDF4053458B6F6" modified="2016-09-07" version="1">MKKIAICTPGFLPVPDIKGGAVEHLLTKILDINEKRKQLEIDLYTIHDDKLNNLSYSNVKIHQIKENKFEKIICKILNKLFNIFKINMQANLYGRKISKLLKNKKFDYIVIENNMYLFKSISSRCSKDNRYIYHLHNDIGGNDKPYRLCNYIANRAEVIVTCSNYLKERFFNVTRFDNIQVLYNSIELENFNLENIDIRSEIRNEWSISDDAFVFMYIGRISPEKGLYELVKAFDKVLAKNSNMYLVIVGEAPDEGFCLNSYYKAVLNIANKHKKNIIFQGKKPNEEIPKIMNASDCIIVPTIIEEAFGIVAIEAMACKKPLIVTNSGGLVEVVNEKCSYIVDKNNIVDELIDKIQIISNNKDKALKMGEFGRERIELIEDFHIENYYDNFINILLGINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6Q8</accession>
    <name>A0A174L6Q8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysE_3</name>
        <name evidence="2" type="ORF">ERS852471_03133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268188.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17100">
        <property type="protein sequence ID" value="CUP17100"/>
        <property type="gene ID" value="ERS852471_03133"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="21724" checksum="E6C1D2FB85A7DD76" modified="2016-09-07" version="1">MKDIVIIGAGGIGREVAWIIEEINEVNKEWNILGFVDDNEEVWGQTLNDYKVLGGIDYFNSLKNKTYVVIAMANPKVKKLISEKLNDEFEFATIIHPTVKIGKFIEIGKGTIIYPGVTLTVNTKIGNHVLISSNCGIGHNIKIGNYSSVLWGCNMSGYDVVGEGVFIGVGASVVNCINIDDGIVINAGEVVVEDMLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LUI8</accession>
    <name>A0A174LUI8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative pyruvate, phosphate dikinase regulatory protein</fullName>
            <shortName evidence="5">PPDK regulatory protein</shortName>
            <ecNumber evidence="5">2.7.11.32</ecNumber>
            <ecNumber evidence="5">2.7.4.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yqfL</name>
        <name evidence="6" type="ORF">ERS852471_03317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43692"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43696"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="2.7.4.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.32" evidence="5"/>
    <dbReference type="EC" id="2.7.4.27" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000044">
        <property type="protein sequence ID" value="CUP27904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268500.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27904">
        <property type="protein sequence ID" value="CUP27904"/>
        <property type="gene ID" value="ERS852471_03317"/>
    </dbReference>
    <dbReference type="OrthoDB" id="980472at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00921">
        <property type="entry name" value="PDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026565">
        <property type="entry name" value="PPDK_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP27904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="267" mass="30188" checksum="0AC291614DF17ECA" modified="2016-09-07" version="1">MLKIFAVSDSIGEIADQVAEAAASQFNDEVKIKRVPYVKTLEDVEEVIKEIKEEENAMIVSTIITVNVREYLTQKAIESNLTVVNVLGPIINVASSLLNQQPQYDPGAMWKTDEAYFKRIEAMEFAMQYDDSKDYRGLKNADVVLVGLSRTSKTPLCMYLANKGIKAINIPLVPEVEIPNELYEIDKHKVFGLTINPLQLIEIRKRRLDKFHRIPSNIEYAGDARILEEFEFADKTMRKLGCKTIDVTQRAIEDTALIIIKALGHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M4G2</accession>
    <name>A0A174M4G2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glcK</name>
        <name evidence="1" type="ORF">ERS852471_03333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000048">
        <property type="protein sequence ID" value="CUP28905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268517.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28905">
        <property type="protein sequence ID" value="CUP28905"/>
        <property type="gene ID" value="ERS852471_03333"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP28905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="32691" checksum="317A83C0C784D403" modified="2016-09-07" version="1">MEKKYVVGVDLGGTKIYTALVDLEGNIINEKIVETLAEEGEEAVAGRIINTIDSVIAGVDKDLIKAIGIGSPGPLDAKKGIIIETSNLPFKNFEIVNVLKERYDLPTYLDNDANVATLAEFMFGAGKGTENMVYITVSTGIGGGAIINGKLYRGNTANALEVGHMTVSKEGPRCGCGNVGCAESFASGTAIGKRAKEAVASKVVTSLKKYNNVTAKEVFIEAAEGDAEAKRILDSALYYLGITVGNVMSHLDPEKVVMGGGVINGGDIVLETVKKVVAERCLSVFAENCSIEKAKLGGQAGVLGAAALAITEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XCS7</accession>
    <name>A0A173XCS7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urease accessory protein UreE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureE_1</name>
        <name evidence="2" type="ORF">ERS852471_00014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051986857.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49561">
        <property type="protein sequence ID" value="CUN49561"/>
        <property type="gene ID" value="ERS852471_00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="77" mass="8873" checksum="E3D1DBCDB9A3C423" modified="2016-09-07" version="1">MALYKVFVVTADTMAEMGKIAHSLGNRHLPAQFQDGKMLLQYDERIEEILKSAHIEYKLDEVSLEVAFRDIDSDHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XF20</accession>
    <name>A0A173XF20_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ureC_1</name>
        <name evidence="5" type="synonym">ureC</name>
        <name evidence="13" type="ORF">ERS852471_00013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118341.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49507">
        <property type="protein sequence ID" value="CUN49507"/>
        <property type="gene ID" value="ERS852471_00013"/>
    </dbReference>
    <dbReference type="OrthoDB" id="157757at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="133"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN49507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="571" mass="61533" checksum="BC2E3FD65E216419" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFM1</accession>
    <name>A0A173XFM1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carbamoyltransferase</fullName>
            <ecNumber evidence="10">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hypF</name>
        <name evidence="14" type="ORF">ERS852471_00034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262718.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50591">
        <property type="protein sequence ID" value="CUN50591"/>
        <property type="gene ID" value="ERS852471_00034"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48295at2"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="13">
        <location>
            <begin position="201"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN50591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="765" mass="87192" checksum="AE2478DFDA1377C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG96</accession>
    <name>A0A173XG96_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureH</name>
        <name evidence="3" type="synonym">ureD</name>
        <name evidence="4" type="ORF">ERS852471_00016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49665">
        <property type="protein sequence ID" value="CUN49665"/>
        <property type="gene ID" value="ERS852471_00016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN49665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="31879" checksum="94BDFD54C4950CB3" modified="2016-09-07" version="1">MINDMNNKIAGNSKLVLENKPNGTVATTSHFVGASKVSPAIFLGREKTPCYFLLHLGGGYVEGEVYKNSIEVKKDAKAIITTQAPTKVYKCEKNREAACQETIIKMEENSVLEYISDSVILYKNAMYNQDTTIYMDKKATLIYTDGITSGWSPDGSKFQYDSVKMRNKIYVDNKLLLLDNLQLSPREYDVTELGILEGYINFGTMVVINENMNENYVEKAREIIDALNLDIKYGVSILEEHGIIIRILGNLTQEIQKAIDAVHYYLREELFGLKPINIRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XP94</accession>
    <name>A0A173XP94_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I restriction enzyme EcoKI subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262772.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52707">
        <property type="protein sequence ID" value="CUN52707"/>
        <property type="gene ID" value="ERS852471_00068"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1197603at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="186" mass="22496" checksum="C44DEC4F6BBCFF59" modified="2016-09-07" version="1">MFSEMAEIIKEKDKYLAEIIKNFEEMLFIDSYTVILKGRTMAERIARNIIAAENIKENEEISQKDRIYLLERERLLEEEVTKAFHTIRYLGNRVIHDEVEGEFETSLTIYRNIYKVLAWYVPLYISNSFEVKEYLEPKVIEKIKNVEKEANGVKNIIMENFLLNLYMDYDKEKYYFHSRKNKKMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSJ2</accession>
    <name>A0A173XSJ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54639">
        <property type="protein sequence ID" value="CUN54639"/>
        <property type="gene ID" value="ERS852471_00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="41" mass="4935" checksum="ABC951378861E68E" modified="2016-09-07" version="1">MCKEESKNVIQMDEIIEVEKVDVKEDNKDDKIREYEDLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XVI7</accession>
    <name>A0A173XVI7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">hutU</name>
        <name evidence="13" type="ORF">ERS852471_00139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262905.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56012">
        <property type="protein sequence ID" value="CUN56012"/>
        <property type="gene ID" value="ERS852471_00139"/>
    </dbReference>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="216"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="443"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN56012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="674" mass="76297" checksum="27D545E84C828689" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0S0</accession>
    <name>A0A173Y0S0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pnp</name>
        <name evidence="9" type="ORF">ERS852471_00164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262949.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57253">
        <property type="protein sequence ID" value="CUN57253"/>
        <property type="gene ID" value="ERS852471_00164"/>
    </dbReference>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="621"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN57253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="700" mass="76924" checksum="5855C6BE5B353528" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8G8</accession>
    <name>A0A173Y8G8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263049.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60149">
        <property type="protein sequence ID" value="CUN60149"/>
        <property type="gene ID" value="ERS852471_00219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN60149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="20578" checksum="25507ED3B4F5DAE1" modified="2016-09-07" version="1">MENLLYTSSPMDVINYIKTINKNYEIWIDFKDEIKYIDPEGMIIKQNIVDPIKITYSNINPIFKIYRRNKNCCILKIIIPEFTITFPNLHNLTYTFLENSLDLHLNLLHFTVEYSDIDSYFDNGLEQYLKRTVDSILHQQFISDNGYTLKCSNYTTYVYSVIQSNKKRKNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBZ0</accession>
    <name>A0A173YBZ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin oxidoreductase</fullName>
            <ecNumber evidence="7">1.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fdh</name>
        <name evidence="7" type="ORF">ERS852471_00221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263053.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60258">
        <property type="protein sequence ID" value="CUN60258"/>
        <property type="gene ID" value="ERS852471_00221"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="663" mass="75748" checksum="385F92C0203B650D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRE3</accession>
    <name>A0A173YRE3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yfiH</name>
        <name evidence="10" type="ORF">ERS852471_00289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263199.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65776">
        <property type="protein sequence ID" value="CUN65776"/>
        <property type="gene ID" value="ERS852471_00289"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1393323at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN65776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="28537" checksum="322A8F8C0C8BBCFA" modified="2016-09-07" version="1">MKKININNLKVFKDFLVIEGEKVDVVFSTAKDSRSFNRNTEEGQKNINSLKEDFNVNEVVYLHQIHSDNVFVFEGDAEEFREYEGDSIITKEEKVIIGAFTADCVPVILVDEREGVIAAIHSGWKGTFNSITKKTIEKMIQEYDVKIENIKVYIGPHIRQCCYEVSEELKESFLNKTKINENELFKGRNLSMERCILEDLRNINIKEDNIYTINLCTYCEKDIKLFSYRKSVGTYGRLFTFAYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6J6</accession>
    <name>A0A173Z6J6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF3783)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263397.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71941">
        <property type="protein sequence ID" value="CUN71941"/>
        <property type="gene ID" value="ERS852471_00400"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014661at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN71941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16152" checksum="38411AC7AFDAFC27" modified="2016-09-07" version="1">MSFEILDKNSDLDNDARSCVILCNFNGKELKAVKNYASILGLRDQICLYSKNGNSIIKDILEDKIDSNCEEGRKEKAIIFNNISNMKINMFIDNLKKIRINNVLKAIVTETSINWTLNEVIVNLLNERAAINNGDFSDLHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD99</accession>
    <name>A0A173ZD99_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin dehydrogenase FAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263479.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74251">
        <property type="protein sequence ID" value="CUN74251"/>
        <property type="gene ID" value="ERS852471_00446"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN74251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="266" mass="30160" checksum="5DEBA1BD2D57332A" modified="2016-09-07" version="1">MFTIKNYIVVQSLEEAYELNQKKNNVVLGGTAWLKMGERNIQNAIDLSGLGLNKIEEDDEFIKIGCMCTLRDMEVSNKLNRYFDESIKESLKYIVGVQFRNCATIGGSIYSRFGFSDILTVLLALDTYVELYKGGIIPLSEYKDMPYDNDILVRILIKKDNRQVRYMTHRNSATDIPTLACAVSKLDGKWKVVLGARPQRAMEVSGVSELLSEIPTKEEIEKVINKVIDEVKFESNMRGSKEYRLLLAKAFIKRGIEGIVGGSYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHV8</accession>
    <name>A0A173ZHV8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nanP</name>
        <name evidence="6" type="synonym">nanE</name>
        <name evidence="7" type="ORF">ERS852471_00475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263529.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75821">
        <property type="protein sequence ID" value="CUN75821"/>
        <property type="gene ID" value="ERS852471_00475"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="25277" checksum="5D26E1FD3DDF1AE9" modified="2016-09-07" version="1">MGKEEILNILRGGLIVSCQALPGEPLYLENDTIMPLMARAAKQAGACAIRTNGVRDVIAIKEETNLPVIGLIKKSYDGYEQYITFTMDEVDQLVEAGADIIALDCTLRKRKDGRTVEEFIKAIKEKYPRLLLMADISNLEEGINAWKAGVDMVGTTLSGYTSYTTKLDGPDYELVENLVNSIKIPVIAEGRIHYPEQAKKMLELGATSVVVGGAITRPLEITNRFIKAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJS2</accession>
    <name>A0A173ZJS2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative N-acetylmannosamine kinase</fullName>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bglK_1</name>
        <name evidence="1" type="ORF">ERS852471_00476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75880">
        <property type="protein sequence ID" value="CUN75880"/>
        <property type="gene ID" value="ERS852471_00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047700">
        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="311" mass="33952" checksum="657B8D66311A2109" modified="2016-09-07" version="1">MYLGIDIGGTAVKIGMVTEEGKILLSNSYDVAFDSYETPIFDTVKKSIELFIRENYIDMKSIEGIGVSATGQVNSNTGTIIGVGGNIKNWCGTEIKKELEEIYNIKTTVVNDANCMVIGEQWVGKGRGYKNIVGVTIGTGVGGGIIVDSKILLGSIGIAGELGHFSINSEGKKCTCGNIGCYEQYASTTALIKIVRDKFEELDILSFKKEDLNGKVIFEEVSRGNKKLQEILDEWIINIGKGLVSLVHIFNPEIIIIGGGVSKQEEFFIKPLRKYVLENVMKRFGENLRVEAAELGNNAGLVGAVYYNIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZR35</accession>
    <name>A0A173ZR35_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0397 protein ERS852471_00490</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0397 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN78882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263579.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78882">
        <property type="protein sequence ID" value="CUN78882"/>
        <property type="gene ID" value="ERS852471_00490"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637464at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01572">
        <property type="entry name" value="UPF0397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022914">
        <property type="entry name" value="UPF0397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN78882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="187" mass="20048" checksum="3025AC11476EA3C1" modified="2016-09-07" version="1">MKNNLSIKTIVAIGIGSAVFMILARFAAIPTPIPNTTFNTAYGFLALMAVIFGPIAGVSIGFIGHTLTDLTAYGSPWFSWIIATAIVGLVIGFAAKRLNINEGEFGKKQIILFNIYQVVANVIAWFVVAPSLDILIYAEPANKVYVQGAVAGFLNMITVAVLGSILLYSYAKSRVKKGSLDREDDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZS68</accession>
    <name>A0A173ZS68_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79121">
        <property type="protein sequence ID" value="CUN79121"/>
        <property type="gene ID" value="ERS852471_00494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="157" mass="18135" checksum="1F7E2D99623F6391" modified="2016-09-07" version="1">MKTAEYYIEKLEMLPHVEGGYFKESFLSESLYNTDKKLWSSIYFLLRTGEVSHFHRLKSDELWYYHAGESLTIYMITPEGNLITKQLGLNIENGESPQVLVPKGCIFGSAMNNDGFSLVGCMVSPAFEYKDFELFNRDELLSLYPEHQSIINKLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSN7</accession>
    <name>A0A173ZSN7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose-1-phosphate uridylyltransferase</fullName>
            <shortName evidence="10">Gal-1-P uridylyltransferase</shortName>
            <ecNumber evidence="10">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galT</name>
        <name evidence="13" type="ORF">ERS852471_00497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263589.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79291">
        <property type="protein sequence ID" value="CUN79291"/>
        <property type="gene ID" value="ERS852471_00497"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801432at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00571">
        <property type="entry name" value="GalP_UDP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000766">
        <property type="entry name" value="GalP_uridyl_Trfase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023425">
        <property type="entry name" value="GalP_uridyl_Trfase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39191">
        <property type="entry name" value="PTHR39191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006005">
        <property type="entry name" value="GalT_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01239">
        <property type="entry name" value="galT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01163">
        <property type="entry name" value="GAL_P_UDP_TRANSF_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="11">
        <location>
            <begin position="56"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="12">
        <location>
            <begin position="250"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN79291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="507" mass="58460" checksum="FE16A1793C14EB4B" modified="2016-09-07" version="1">MVNVGYEIERLLKFALKKEMISKWDVIPSRNALLDLLKVESPYEGIVEEVVEDTPVKILKNILDYAAENNLIEEDTVTYRDLFDSRIMGLLMPREGEVVNKFNKIADRKGLEEATNWFYDLSKSSNYIMTERIAKNLYWLSETEYGDLEITVNLSKPEKDPKEIAKAKLVKQSSYPKCLLCIDNVGYAGRLNHPGRQNHRVIPFELQGKDWFLQYSPYVYYNEHCIVFKGEHSPMKLGRDALERLVEFTDKFPHYFIGSNADLPIVGGSILTHDHYQGGRHVFPMEKAKIEKYYESDKFKNVEIGTVKWPMTVIRLKSEDKKALVDVAMEIFEAWKVYSDEANDILAFTGETPHNTVTPIARRNNGAFELDIVLRNNRTSEEHPDGIFHPHKELHHIKKENIGLIEVMGLAVLPGRLEKELEKIAEIISGEVSYDREVALEDNDLNKHIDWIEEMLNKNSDMNLEDARNFVKEEVGIIFSKVLEDSGVFKRNKKGQAALEKFITSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZY96</accession>
    <name>A0A173ZY96_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yffB</name>
        <name evidence="2" type="ORF">ERS852471_00524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263636.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81402">
        <property type="protein sequence ID" value="CUN81402"/>
        <property type="gene ID" value="ERS852471_00524"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1606021at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="112" mass="13166" checksum="4EBE65353E93534B" modified="2016-09-07" version="1">MNIQIFGTKKCFDTKKAERYFKERRINFQFIDLKEKSLSKGELSSVKNSVGLENLINKSAKDYKKLNLDKIRTADMREEILFKNPSVYVTPIVRNGKQATVGYKPEVWNEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AA58</accession>
    <name>A0A174AA58_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84749">
        <property type="protein sequence ID" value="CUN84749"/>
        <property type="gene ID" value="ERS852471_00569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN84749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="30014" checksum="A89D7D2DD855421E" modified="2016-09-07" version="1">MPISMREEVNNRVTRNRKRKRRKYIVAGVIIITTFGIYKINYYCKQKEVASVIIEENKYIENEEATIKNSRSASNEYLMLINKVSGINQNYIPPDLVIPNVKFRVADDMCREMRVDAAKALENMFNDAMKEGINLIAISGYRSYEYQQEVYDRSVAIEGQEYTNNYVAVPGTSEHQTGLVMDLLSDEYLSLDEGFENTRAFQWLKENMSNYGFILRYPKGKEDITGYDYEPWHLRYVGVDVAEEIMSKGITLEEYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHW7</accession>
    <name>A0A174AHW7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA primase</fullName>
            <ecNumber evidence="5">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dnaG_1</name>
        <name evidence="5" type="ORF">ERS852471_00601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263777.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87125">
        <property type="protein sequence ID" value="CUN87125"/>
        <property type="gene ID" value="ERS852471_00601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1371356at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="4">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="188" mass="21883" checksum="83C2DCD9C634376E" modified="2016-09-07" version="1">MVNELIKEIKTRSNIIDVAKLVGINLNRANKCLCPFHSENTPSFSISEKKQIFKCFGCGETGDSITLVSKILNIKPYKAAQYINDSLALGLNLSKNKCKSEFKFPNKYKQKMLILEEFKRVENEIFILLSDYRRYLAEKNDDETAMMLEQIDYYLDIFIEGDERDKLQFLINNKKIINKLRMGGNYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKE4</accession>
    <name>A0A174AKE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription antiterminator LicT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">licT_1</name>
        <name evidence="2" type="ORF">ERS852471_00619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263812.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88359">
        <property type="protein sequence ID" value="CUN88359"/>
        <property type="gene ID" value="ERS852471_00619"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1193348at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="173"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="32295" checksum="8E58E470BEEB76EC" modified="2016-09-07" version="1">MIIKKIFNNNAVVAKDSANREVVAMGCGIAFKMSVGEILDQSKVEKTFILKEKEASERFKLLLEDVEPDVVSLCYDIIEYAKNILNGSLNDYIYVTLTDHIYNVLKLQKEGFNRPNVIIWEIKKFYPKEYAVGQKALEFIKDELEVELPEDEAGNIALHLINAQVNKNSDKVQDVAKQAKMVQDILNIVRYTYNISLDEKSLSYERFVTHLRFFFQRLNRKDKIEPKNDDFLLKQVKMKYEDAYNCMLKIEKYLNVELDDEEKLYLTLHVQRITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASH8</accession>
    <name>A0A174ASH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263866.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90345">
        <property type="protein sequence ID" value="CUN90345"/>
        <property type="gene ID" value="ERS852471_00652"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="16920" checksum="4EFF78D03D13C9B5" modified="2016-09-07" version="1">MDKLFLTVLKMSITSSYVILFVWLSFILMSKDMEMSCDETVVKELGSKIKKEYSMSLLLFATDKNKVGIAPIAFGEGEVKSRVKNVLNYKKPSFGVVLVSVIALITVAIGLMFNPINNEESNKYLEDNNLKGISLLERGYDEPDKVIPLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATZ3</accession>
    <name>A0A174ATZ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263890.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91379">
        <property type="protein sequence ID" value="CUN91379"/>
        <property type="gene ID" value="ERS852471_00665"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN91379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="21812" checksum="0C91A3F824C9FDD3" modified="2016-09-07" version="1">MKAILIMNEEHKNISRMLKVVRACCSRVLKGEDINYDDFDKILEFIVEYADKHHHKKEEDILFDKMVKHLGGTAEKVVKTGMLVEHDLGRLYIKDLNRALEKVKDGDEDAKLDLIANAISYTHLLERHIDKEDRVIYKYAERELDINILELVNKECNDFEDKNNYVKEKCLSILEELEKRYIMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZ34</accession>
    <name>A0A174AZ34_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263950.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94071">
        <property type="protein sequence ID" value="CUN94071"/>
        <property type="gene ID" value="ERS852471_00685"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833118at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="186" mass="21538" checksum="4F5C47C62D658B95" modified="2016-09-07" version="1">MERSIREFIGITIIIVILFFAMSGISSLGKNEIDPETIGKFKIYSKDINTDKEIIVEEFGFYKDVDTIEKRLKIIASKLSDSEFKMLPIELIGIEEIDGKIIATFNLKENEENLNESDWTKYSEPSWAKNFFQGSAGGSWTCYTLQTTMLQPEYDGKWIDGVRFLYNGEENKNFQHIEGLDQIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BA82</accession>
    <name>A0A174BA82_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264014.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96650">
        <property type="protein sequence ID" value="CUN96650"/>
        <property type="gene ID" value="ERS852471_00725"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="16630" checksum="16E50D39393677A4" modified="2016-09-07" version="1">MCKVIAVCTSEKKGTAKQMVDEANLIEEFGIEGDAHAGKWHRQVSLLGLEKIDEFNSKGGGVNFGDFGENLVISGIELTKMPIGQRFKVGETILELTQIGKQCHDKCEIFYRVGQCIMPTNGVFTRVIKGGKVRVGDEVILLESERKTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBR2</accession>
    <name>A0A174BBR2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264065.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98054">
        <property type="protein sequence ID" value="CUN98054"/>
        <property type="gene ID" value="ERS852471_00752"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1852106at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="16037" checksum="69614A459F5960E4" modified="2016-09-07" version="1">MVQKRSKKNRTYTRVQRLKKRRKKLFAIIFPIVVVVLLITSGILLKGKYVSYRCSNLTYAIDYYFTNWKDKDLRINRVQSMTFVDKTEDKVIVEAFGLSHNEPHQRTTLVGELTKDSSGSWVMNSLEKKDDSQKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKM9</accession>
    <name>A0A174BKM9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmuC_2</name>
        <name evidence="11" type="ORF">ERS852471_00813</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264187.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01304">
        <property type="protein sequence ID" value="CUO01304"/>
        <property type="gene ID" value="ERS852471_00813"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00359">
        <property type="entry name" value="cello_pts_IIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="7"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO01304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="427" mass="46532" checksum="C1767B9D2CEB3D3F" modified="2016-09-07" version="1">MNFYQKFEGKIMEFGTKLNNLKVLRVLRDSFMISFPLIIFGSIMLVIANLPFLDKILSPETLNSLKTFLGPASMTTMSITTIFVTLGIGYYFSKEEGVDPIFGAAISLVSFLLLTPTADGGDLGSVLQIDRLGAKGMFIGMIAAFLSAYMYTFFVKKNWTIKMPDTVPPAVSKSFAALIPAVFTLSTFLVINIIFTFTPWGNPHDFIYEIIQTPLTKLGSGIAATVVAIFAVQILWFFGLHGQIIVNSVMDPIWNTLSLENLNAFQAGAEMPNIITKQFIETFTVGLGGTGMTLIVILAILIFMKSRQLKEIARLAAPAGLFNVNEPVTFGLPIVLNPIIAIPWIIAPVVATLVAYFAMASGLVPATTGVAVPWTTPVLISGFLATNSIAGSILQLVQMAIVLVIWFPFLMALDKRNCDLEKEEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2X7</accession>
    <name>A0A174C2X7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032116765.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06066">
        <property type="protein sequence ID" value="CUO06066"/>
        <property type="gene ID" value="ERS852471_00876"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1805087at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014875">
        <property type="entry name" value="Mor_transcription_activator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08765">
        <property type="entry name" value="Mor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mor" evidence="1">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO06066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="83" mass="10121" checksum="B73AC474599BD7AC" modified="2016-09-07" version="1">MNKSDYNGVYEELVELLGLENTLKIHKYFRGQQVNFPMRLYSKEYIEEYLIKNYNGKNLKELSKKLDYTTNWLRKMLNKIEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CEM0</accession>
    <name>A0A174CEM0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(FAD)-dependent dehydrogenase</fullName>
            <ecNumber evidence="2">1.18.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bedA</name>
        <name evidence="2" type="ORF">ERS852471_00988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.18.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264523.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11752">
        <property type="protein sequence ID" value="CUO11752"/>
        <property type="gene ID" value="ERS852471_00988"/>
    </dbReference>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008860">
        <property type="term" value="F:ferredoxin-NAD+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="416" mass="45892" checksum="E0AB4993106FA2B9" modified="2016-09-07" version="1">MEYDLIVIGGGPAGLAAAYEAHKEGIEKILIVERDKELGGILNQCIHNGFGLHTFKEELTGPEYAERFIDMVKSTNIEVKLDTMVLEIEEDKTVHAINTEDGYMILNAKAIILAMGCRERTRGAIAIPGDRPSGVLTAGAAQRYINMEGYMPGKEVLILGSGDIGLIMARRMSLEGANVKAVVELMPYSNGLNRNIVQCLNDYDIPLYLSHTVVDIKGKDRLEKVIIAKVDENRAPIKGTEIEFDVDTLLLSVGLIPENELSSKAGIEGDRRTNGLIVSESMETSIDGVFACGNVLHVHDLVDFVSEEANRAGKCAAEYIKGELKRGSYLKVINGKNINYTVPQKISTDSMKDNLTMFMRVNNIYHDKKIVVRSGENIVAEFKRKHLAPSEMEKIILKKSLLENVVEDLVVSLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CKF6</accession>
    <name>A0A174CKF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264536.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12679">
        <property type="protein sequence ID" value="CUO12679"/>
        <property type="gene ID" value="ERS852471_01004"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562183at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="21336" checksum="8D87246E7620CAA8" modified="2016-09-07" version="1">MKELETRIVDIDVDDIRNKLISLGGEKVKSEDQVNEIYDFEDGRLLAAKGYARIRTTVDRIKGKETVFMTTKKMLSQDTFKVMEENEVIVDNKDMARRIFTSLGLKLQESISKYRESYKINDSLVEIDINDKSFCPFPYLEIETTSVEKLEEIVKLLGYTLEDTTSQTIYDILAERGIQGKTKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPY9</accession>
    <name>A0A174CPY9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kcsA_1</name>
        <name evidence="10" type="ORF">ERS852471_01028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264564.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15194">
        <property type="protein sequence ID" value="CUO15194"/>
        <property type="gene ID" value="ERS852471_01028"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1991946at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="9">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="262" mass="30437" checksum="5AE7DEFDE77C40FE" modified="2016-09-07" version="1">METKSQRFLYELFMMILALVVVTITIIQLTMTLSSEMDRIITIIDNGIYILFLLDYFTRLIKSENKWSFIKNNKIDLITIIPFNSLFMALRIFRFLRVTEFLKALKALKATVFINNIVKKVRVVLRTNYFNYVLLITITLIFSCAAFISIFENIRFKDALWWSFVTTTTVGYGDIAPTSDLGRIVAVILMITGVTFMGVLTGTISTYFLRKDRERNKGDYKYEAIEEIKERLDDFDNLSRGELEIITKVLLSLKEENDGDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D040</accession>
    <name>A0A174D040_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17348">
        <property type="protein sequence ID" value="CUO17348"/>
        <property type="gene ID" value="ERS852471_01069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019607" evidence="1">
        <location>
            <begin position="25"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="346" mass="35912" checksum="2C69EB3397F030E7" modified="2016-09-07" version="1">MKAKKIIGLCLAAALVVGMVGCQSATSNGGNNTQQEASAEKVTLKIGQTNFAAHGTKAFAMVTAVVNGDEIVDAYIDEFQYMSADSATGIVNSEGMADNIAEGKVLASKRENNETYSASLAEKAGSTVKYTDNLVAIQDFVKGKKISELEDLVNNKSAEEVTDAVTGATLADTAGYIKAVLEAAKQAEGTTGVEFAGNLEDLKLSQVYAAAHGTKAFAVVSALTDNDKVVLSYIDEYQFMAADGTTGVANSTEGLADNVVEGKVLASKRQNSDAYSATMAEKAGSTVKFADNLNAIQEFVDGKTVSELEEVTAKTNEEVTDAVTGATLADTAGYINGVIQAAKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAE4</accession>
    <name>A0A174DAE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhhT_2</name>
        <name evidence="7" type="ORF">ERS852471_01144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264662.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21008">
        <property type="protein sequence ID" value="CUO21008"/>
        <property type="gene ID" value="ERS852471_01144"/>
    </dbReference>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="387" mass="43504" checksum="D4F9083B34A6E97C" modified="2016-09-07" version="1">MKVEWNKRYTTIAIYSFVVIACSILLYMIMSNIDEFSSKVDGMIVTLRPFIIGGAIAYLLNFMLKFYENLLSKWDKFNKQSKKVKRSVGLILTYLSAMIMVYLFLQFVLPQLVDSILGLANSIPQYVKDLSNFTNDLLSKVDLEPQFIELLMKQWNDLINAIIAFITNMVPVIGNMLLGLSSSLFSIFIGVIVSIYMLIDKEKLLALSRKIIFAFSPNERAKFILRIARISNDTFGKFLVGKIIDSLIIGVLTFCILSICKMPYTLLISVIIGITNIIPFFGPFFGAIPSVIIVLFVSPTKALWLILIVFIIQQIDGNIIGPKILGDSIGISAFWILFSLLIFSKLLGFVGMIVGVPIFAVVYSLIKETVELRLKSKGLPTSTDEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DL14</accession>
    <name>A0A174DL14_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rffG</name>
        <name evidence="7" type="ORF">ERS852471_01219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264738.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25887">
        <property type="protein sequence ID" value="CUO25887"/>
        <property type="gene ID" value="ERS852471_01219"/>
    </dbReference>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="5"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO25887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="349" mass="40496" checksum="B09DD35D6E18CF1E" modified="2016-09-07" version="1">MKTYLVTGGAGFIGSNFILFMLKKYSDIKIINLDKLTYAGNLDNLKSVDNDERYTFIKGDICNKRLIKEIFAKYDIDYIVHFAAESHVDRSINNPEVFVKTNVLGTVTVLNGAKEVWEKGGKWEDGVKFVHISTDEVYGSLGDTGYFTENTNLDPHSPYSASKASADLLVKSYYDTYKMPVNITRCSNNYGPFQFPEKLIPLIINNCIEKKELPIYGDGLNIRDWIYVEDHVRAIDMVINSGRLGEIYNIGGRNERTNIDIVKSIIDYFKKNVDYTIDESLIKFIEDRKGHDRRYGIDPTKINEELGWYPKMDFYVGMKKTIQWYLNNQDWINNIKLGEYKKYYNKMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQ68</accession>
    <name>A0A174DQ68_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264746.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26245">
        <property type="protein sequence ID" value="CUO26245"/>
        <property type="gene ID" value="ERS852471_01227"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2000207at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="131" mass="15329" checksum="66A58DF2CE686118" modified="2016-09-07" version="1">MKVNEIVSFLQENELGDVEILKSEKDLLLVNFYYDFDEDLLAAAKAYAKEECEDESSEAWEKEYYLPYLYDFCNDEVLSIVEDITEELNIAGEFMAFQMKDRTAEYVQFMALFTNEDSDISIEEVVKDYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DR21</accession>
    <name>A0A174DR21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264761.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26709">
        <property type="protein sequence ID" value="CUO26709"/>
        <property type="gene ID" value="ERS852471_01237"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630935at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="157" mass="18766" checksum="A3948C076A227E13" modified="2016-09-07" version="1">MKKVNDILNNTLYKENLEKLLKYEEKREFCRHDLKHFIDMARIAYIMVLEKGLPYSKELIYAIGLLHDIGRVKQYEEGIPHHIASVELSKEILKKIDFTEEEKNIIIKSIQNHRKEADDELSLIIYRSDKLSRECFNCKAINDCYWSDEKKNLKINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVQ0</accession>
    <name>A0A174DVQ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LrgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lrgA</name>
        <name evidence="7" type="ORF">ERS852471_01264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264811.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27970">
        <property type="protein sequence ID" value="CUO27970"/>
        <property type="gene ID" value="ERS852471_01264"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846131at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO27970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14592" checksum="F190550BE175D154" modified="2016-09-07" version="1">MKIFREFIIILVLYFIGELISKIFNIPIPGNIIAMILLFVSLCTGIIKVEKVDDISTFFLDHLAFFFIPAGVGLINSFDSIKSSAIQIIIICIITTIIVMAVTGIIVQFTSNMLAKKKEDKKSDYKRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZI2</accession>
    <name>A0A174DZI2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exoenzyme S synthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ttcA_2</name>
        <name evidence="3" type="ORF">ERS852471_01327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264923.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30854">
        <property type="protein sequence ID" value="CUO30854"/>
        <property type="gene ID" value="ERS852471_01327"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO30854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="241" mass="27441" checksum="D6D8F66793BBCE8A" modified="2016-09-07" version="1">MQKLLSKTRQAINDFNMISDGDKIAVGLSGGKDSVTLLHILKNYQKFSPQKFDLIAITLNPGDVDNGPLHTLCKKINVPFYEIQTDIAKIVFDIKNEKNPCSLCAKLRRGALNDAAMKLGCTKVALGHHKDDAVETFVMTMFYEGRVNCFAPKSYMEKFNLTIIRPMVYIDEYMIKKAVKDYNYPIIKNPCPADGHTKRQEVKDLIKNLNSTFPNLKNKLFSALNNSDQLYIWNKDEIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E440</accession>
    <name>A0A174E440_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264945.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31278">
        <property type="protein sequence ID" value="CUO31278"/>
        <property type="gene ID" value="ERS852471_01339"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902170at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="136" mass="15596" checksum="BF154D3A7DA087B1" modified="2016-09-07" version="1">MEYMLSTHELGKLLSDLCNKYEISMLWREKISGGFITLTGIIDVEYYPTDKVMLKGNNIISLKVKSGNNSNVVKITGMKGEYFNISLAPTKFKEIKSNSLYLNQIQESKTECKLRIDENIIFTIPESYNEITKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6Y6</accession>
    <name>A0A174E6Y6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">lysS</name>
        <name evidence="12" type="ORF">ERS852471_01367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8 9">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264999.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33503">
        <property type="protein sequence ID" value="CUO33503"/>
        <property type="gene ID" value="ERS852471_01367"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="181"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="501" mass="57590" checksum="B920F464A1BC66A3" modified="2016-09-07" version="1">MSTEEMNIQELESQFSEQEALRREKLAKLQAEGKDPFDVYKVNRTHSSKEVKDNFDTLEGKEVTVAGRIMSKRGQGKVVFSDIHDRDGKIQLFIKIDEVGEEALKQYKTNDIGDWVACTGEVFKTKTGEVSVKAKEIELICKSLKPLPEKWHGLKDPDLRYRQREVDIITNPEVKETIIKRTQIIKGIREFLDNRGFLEVETPILGAIAGGAAARPFITHHNTLDIDMYLRIATELYLKRLIVAGLEKVYDMGKNFRNEGMSVRHNPEFTMIELYEAYADYNDMMEITENMIEYVCKKVNGTTKVTYQGTEIDFKAPWRRITMVDAVKEYAGIDFNEIKTNEEAQAIAKEKHLEFPKPLNTVTKGEVLNMLYEEFCEQHMIQPTFIIDYPVEISPLTKKKRGNEMFTERFEGFVFGRELCNAYSELNDPIVQRERFAQQAKERELGDDEAYMIDEEFMSALETGMPPTGGLGIGIDRLVMFLTDSASIRDVILFPTMKPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EI42</accession>
    <name>A0A174EI42_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_7</name>
        <name evidence="6" type="ORF">ERS852471_01459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37544">
        <property type="protein sequence ID" value="CUO37544"/>
        <property type="gene ID" value="ERS852471_01459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="55"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO37544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="378" mass="42268" checksum="02B0EFDE1030DC3C" modified="2016-09-07" version="1">MEMKSKAYKKEQKARLKEIKKFNSKMYKKYNKEKKLKNVPESHYTTNMSNENNILEFHNLQTHFFTDSGTVKAVDGVSFSIPKGATVGIVGESGCGKSVTSLSIMRLLQGPQGQIVGGEIRFNNKNTGKAVDITKLPLSEMQKLRGNEISMIFQEPMTSLNPVFTIGDQLAEPLILHEPKLKKDDVEKKVIDLLKLVGIANPEGIVKRYPHELSGGMKQRIVIAMALSCNPQLIIADEPTTALDVTIQAQILDLLRDLKDKINASIMLITHDLGVVASMCDYVVVMYAGRVIEQGTVHEIFKDPKHPYTIGLIKSLPSMNTGSDKLYSIPGNVPNPINMPNHCYFKNRCDQCMDKCFGDYPPIKDVTKTHKVSCHLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EM40</accession>
    <name>A0A174EM40_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">arlS_2</name>
        <name evidence="10" type="ORF">ERS852471_01454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265146.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37295">
        <property type="protein sequence ID" value="CUO37295"/>
        <property type="gene ID" value="ERS852471_01454"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="242"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO37295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="455" mass="53131" checksum="ED99C5F5A1625B06" modified="2016-09-07" version="1">MKTKKVPIFLEFMKKSFFIIGLILFIYTIGQLIAFGMFTDEYERDLLKDRYKEIVSLSQDINVQISENSFYQYLQHLANDDEYIRIYSSNKIYYESLSEVWENIKFDYLNKDISIKPRFFDSDIYMVLTAPINIAGSEYTLQIARENEMLKDFTENSFPILIFTLILGLILSGIGAIYVSKNFINRLRRLTTTMNEIKENGINKRAEISGLNDEIDKVNIVFNSMMDELEEAFHEQSRFVSDASHELKTPLTALHGHLSMLKRWGKNDKDRLEKSLDICLKEVERLKKLVNDMLLLSKAEKSEINLDKLEEINPIIVVDEVIEEYRVLKPNVKYIVNTDEDINMKIDPNDLKQLLIIFIDNSIKYNNKDNIEIEITLKKEASKLKLEVKDNGIGIPENEINNVMKRFYKIDKSRVNNNSFGIGLSIANRIANNYNAKIQIDSELDKYTRISVYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYA8</accession>
    <name>A0A174EYA8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wzxC</name>
        <name evidence="2" type="ORF">ERS852471_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265320.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42784">
        <property type="protein sequence ID" value="CUO42784"/>
        <property type="gene ID" value="ERS852471_01545"/>
    </dbReference>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="475" mass="53712" checksum="F6B11E1487088387" modified="2016-09-07" version="1">MSDISIKKAAVINFISRYSNIFVQLIINSILARLLTPDDYGVVAVINVFISFFTIIADMGIGPAIIQNKDLNKKQISDIFIFTIFTGIVIAVGFALFSYPISIFYNNTVYISLGRILAIGIFFNILNIVPNALLLKNKQFKSLGIRTVIITVVGGIITIVIALGGAKYYALVINSILVAVLTFIFNIYYSNMKIYYSFSIDSIKVIKDFSSYQFGFNFINYFSRNTDNLLIGKVLGEVPLGYYDKAYKLMLYPVQNLTHVITPVLHPILSDYQSDRDYIYETYMKIVKILSLVGIFFTVFCFFASNEIILIMFGKQWSNSIIAFKILSLSIWPQMVTSSTGVIFQSLNATKQLFVTGLITTAVNVMLIVTGLCMGKIEYVAMGVVISYILSFLISYFILIKKVFNKSLFKYILSFRNDIIVLLIVALGLAITNIKINNILISVIYKFVVSCIFYIIALFITKEYKSLIYIIKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYQ3</accession>
    <name>A0A174EYQ3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">murQ_2</name>
        <name evidence="3" type="synonym">murQ</name>
        <name evidence="5" type="ORF">ERS852471_01519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265270.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41666">
        <property type="protein sequence ID" value="CUO41666"/>
        <property type="gene ID" value="ERS852471_01519"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100044at2"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="57"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO41666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="301" mass="32652" checksum="E4F08D9E171C0A07" modified="2016-09-07" version="1">MEINLQRLDTEQVNENTKNIDNLSTLDMVTAINNEDKKVALAVEKVLPNIANAVDETYKRIKSGGRLIYIGAGTSGRLGVLDASECPPTYGVEFELVQGIMAGGRDAMFKAKEGAEDSKELAVEDLKAINLTEKDMVIGLAASGRTPYVIGGLEYAKEIGAGTGSISCVHDSEVSKVAEFPIEAVVGAEVVTGSTRMKSGTAQKMILNMISSGVMIKLGKVYGNLMIDVRPTNEKLVERAKGIIMKCTDVTREVAEEYMRLSGNDVRLSIFMILSKLDKEESINVLNKNDNNIRKALESIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZZ6</accession>
    <name>A0A174EZZ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD_2</name>
        <name evidence="4" type="ORF">ERS852471_01559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265350.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43662">
        <property type="protein sequence ID" value="CUO43662"/>
        <property type="gene ID" value="ERS852471_01559"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO43662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="297" mass="33172" checksum="2F38851B518C24C7" modified="2016-09-07" version="1">MKILITGSNGQLGNELQRIIATGSAEIGEVSNEIKTSKVFALDVDKLDITNLQQVKTVLSEIKPDVVINCAAATNVDGCESNQDLAFKINAIGPRNLAIVCEEIGAKLVQVSTDYVFSGVGERALTEFDLTAPYSVYGKTKLLGEEYVREFSSKYYIVRTAWLYGYIGHNFVYTMMKLGNMKDEISVVNDQLGNPTHANDLAYEILKLIETEEYGVYHCTGKGECSWYDFASEIMKLSGRNCKVNPCTSEEYKVMNPNAAKRPEYSSLDNMMLRCTIGDEMRDWKDALKSFMSNVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHJ8</accession>
    <name>A0A174FHJ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein, subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mreD</name>
        <name evidence="9" type="ORF">ERS852471_01653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265528.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49007">
        <property type="protein sequence ID" value="CUO49007"/>
        <property type="gene ID" value="ERS852471_01653"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1487171at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017225">
        <property type="entry name" value="Cell_shape_determin_MreD_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037497">
        <property type="entry name" value="MreD_Clostridium/Treponema_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO49007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="18388" checksum="DC16D42D44545B76" modified="2016-09-07" version="1">MKRIVIVAIALFLLILENTILPSYSIMQGYPSILFVFAIAFSIINGKKDAMFIGIVSGVLQDLFFINGFGINLLVNFLLCLLAAKIGEGILKNNRLIPVISCFIISILKIIMIAILFIAFDKKVDFNMAIVSAVLNTIVMLIGYKFVLTTSKKFWKKDEWRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV71</accession>
    <name>A0A174FV71_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C69 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pmbA</name>
        <name evidence="5" type="ORF">ERS852471_01759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265719.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54154">
        <property type="protein sequence ID" value="CUO54154"/>
        <property type="gene ID" value="ERS852471_01759"/>
    </dbReference>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="114"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="225"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO54154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="447" mass="48491" checksum="0B55FC75B78A7527" modified="2016-09-07" version="1">MKLNQFVNELFDKAKEVGFAECEVYYVDRESLSIGVYKGEVEKYNLNNSYGLSFRGKINDKIGYSYTEILDKEAIDMLVRSAKESALAVESDDIQFIYEGDKEYKDVSTYYPALENIEADKLINIALGMEREAKELSDKVTNFSGCSVSYSSGKYGIINTKGLNLKNKSNILTAYVVPILTIDDKMYDGFGYVVAKSLDEVDVKKIAKQGIEEALSKVNGKSIESGSYPIVIKNEAMVSLLSTFAGVFSADAAQKGLSLLKDREGEVIASSNVSLVDDPHLEDGLATVGFDDEGVATKKTYLIKNGKLETLLHNLKTANKAGVKSTGNGFKGSYASPISVSPTNFYIEPGDKNFDGIISSIDKGLIICDFAGLHSGANSITGDFSLAAKGFYIENGKKAFPVEQITIAGNFFDMLKNIEEIGNDLLFPMSSVGSPSIKVNGLSVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G833</accession>
    <name>A0A174G833_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">scpB</name>
        <name evidence="5" type="ORF">ERS852471_01788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ScpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56615">
        <property type="protein sequence ID" value="CUO56615"/>
        <property type="gene ID" value="ERS852471_01788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01804">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO56615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="23437" checksum="65168187EA7A8719" modified="2016-09-07" version="1">MDEKQFEFEEVSIKPKMKSAIEAMLFVSGEPLPAKELMANLEIDNKLILEIINEMMEEYKKEDRGLRLIEINGGYQLVTKEENSDYIQKLLKKNRKHSLSQASIESLAIIAYKQPITRIDIDEIRGVKSESALQRLVERSLIREVGRLEVPGRPILYGTTDEFLRQFGLKNLKELPSLDLYEDKDTEESIELMDQVFKDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9V6</accession>
    <name>A0A174G9V6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265828.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57906">
        <property type="protein sequence ID" value="CUO57906"/>
        <property type="gene ID" value="ERS852471_01815"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035639at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO57906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="129" mass="13798" checksum="513B6E1CB5329945" modified="2016-09-07" version="1">MENVKTDSALGIVKISDEVVSVIAGIAAEEIDGIIELPQGVGNNISQILKGKKNNLGKSVKVTLVEDKAVIDLSVAVEYGVKIPDVVNSVQENVKKTVETITGLSVEAVNISVQNIYVPKQEQENLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCH2</accession>
    <name>A0A174GCH2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="3" type="ORF">ERS852471_01836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265868.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58766">
        <property type="protein sequence ID" value="CUO58766"/>
        <property type="gene ID" value="ERS852471_01836"/>
    </dbReference>
    <dbReference type="OrthoDB" id="713667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="457"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="578" mass="66826" checksum="87439EA72DBA7ACC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDW4</accession>
    <name>A0A174GDW4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">pheS</name>
        <name evidence="16" type="ORF">ERS852471_01882</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265949.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60762">
        <property type="protein sequence ID" value="CUO60762"/>
        <property type="gene ID" value="ERS852471_01882"/>
    </dbReference>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="15">
        <location>
            <begin position="117"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="339" mass="38153" checksum="784391959B532406" modified="2016-09-07" version="1">MQEKLLAIKEAAFDEISAAENSGALEEIRVKYLGKKGELTTILRSMGALSKEERPVVGKLVNEAKNEVEERLEEVSKKIKEKEKNAKLASEVIDISLPGKRNVIGKRHPLDLTLESMKEIFISMGFTVEEGPEVELDHYNFEALNIPKDHPARSEQDTFYINDNIVLRTQTSPVQIRTMEKQEPPIKMISPGKVYRSDAVDATHSPIFYQMEGLVIDKGVTFADLKGTLELFAKKMFGDKVVTKFRPHHFPFTEPSAEMDATCFVCGGEGCRVCKGSGWIEILGCGMVHPEVLRNCGVDPEVYSGFAFGFGVDRMVMLKYGIDDIRLLYESDMRFLNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH32</accession>
    <name>A0A174GH32_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61251">
        <property type="protein sequence ID" value="CUO61251"/>
        <property type="gene ID" value="ERS852471_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6251" checksum="F25F5BCD1845C505" modified="2016-09-07" version="1">MPKDSQPDNKYARMEKCNYQTPITEEGHNHNPNRKHKSVKREGVSSEHYNPAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHM9</accession>
    <name>A0A174GHM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
            <ecNumber evidence="3">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdaA_3</name>
        <name evidence="3" type="ORF">ERS852471_01899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265974.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61451">
        <property type="protein sequence ID" value="CUO61451"/>
        <property type="gene ID" value="ERS852471_01899"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO61451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="29100" checksum="51FB9C241CBC2416" modified="2016-09-07" version="1">MFRKRKIIIAIFLIIGTMVTSIIGAKSMLVNGNLDKKPIFKVNTDKKQVALTFDVNWAENEYLYDILDVLNKYNVKATFFVMGKWIIYPEGNKEKLIKINEMGHEIGNHSYVHPSFSKIDETRMLEELTKTDNIIYETIGVKPTLFRFPSGDYNDKALQFVLENGYKCIQWNCDSVDWKQSGKDIEYERVMKNVSAGSIMLFHNNAKYTPSNLDRIIPKLQEEGYEFVTVGELTDYDEYYIDENGEQHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GL81</accession>
    <name>A0A174GL81_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurite resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266016.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63113">
        <property type="protein sequence ID" value="CUO63113"/>
        <property type="gene ID" value="ERS852471_01921"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1910565at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="139" mass="16355" checksum="68ED60213729C36D" modified="2016-09-07" version="1">MLLFELNKEESRAFMRLVSEFVTVDKKINKEEKSVIEKYLNKLNMNKEEINEISHTEAIEILDKSEDKIKNMVYFELLGVALIDGDYETSEVDYLEEVADKFNISRATKIALANYYFDVDKMKNKSEEEVKEKLIKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GNE4</accession>
    <name>A0A174GNE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61965">
        <property type="protein sequence ID" value="CUO61965"/>
        <property type="gene ID" value="ERS852471_01913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="43" mass="4921" checksum="DFDADBAA858B5EA7" modified="2016-09-07" version="1">MGNQMKKTKKQKKNISHNPQVESVKACFGEPKAKPYDPTDFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRL5</accession>
    <name>A0A174GRL5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63656">
        <property type="protein sequence ID" value="CUO63656"/>
        <property type="gene ID" value="ERS852471_01934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="360" mass="40920" checksum="90C8F86DEC3136EA" modified="2016-09-07" version="1">MDNLKRRHFFPGGNTSKGFYSFYRYILSQDDAKRILCLKGGPGTGKSSLMKKVGDYFFNKGYTIEYHHCSSDNNSLDGIVIKELGVALIDGTSPHIVDPITPGAVDEILNMGDALDMDMLSKHKRDILCINRDISKCYKRAYRYLAAARSIHDDWSNLNYESLDSNKISVLIETLKNDIFRTDISGYGGERRLFATAITPNGIITFADNLSNGYKNIYVLTGGPGMGKTDILKYLGTSGQKKGYYVEYMYDPFIPERIEHIFIPEISTCVLTNNEINRANYSGINYYLKDYTKPNSLASKASEIEYNSKIFYELLDKAISLISNSHALHDDLEEFYIKAMNFDVVNTMYENVIKKIEKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVB8</accession>
    <name>A0A174GVB8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpR_2</name>
        <name evidence="5" type="ORF">ERS852471_02005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66473">
        <property type="protein sequence ID" value="CUO66473"/>
        <property type="gene ID" value="ERS852471_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO66473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="29039" checksum="0CBD5EF8D14A723A" modified="2016-09-07" version="1">MLAIVRRQKIVDIIQDKKKVLVQELAANFSVTEETIRRDLEKLEEQGILKRTYGGAIINQGTNVDMPVDMREISNKEGKMKIAEQVSQSIQEGDTLMLDSSSTAFYVAKCIKKSKKRVTIITNSLKVLIELQDTKDVNLILAGGSFRESAKSFVGKWSESVIQNYYVNKAIICCKGMDINRGVMDSNEQEAEVKKLMAGSADKVFLVVDSMKFDRSSFVNIVDFDQIDYLYTDEPLSKKWEKVLRENDVKVNICKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWP0</accession>
    <name>A0A174GWP0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266108.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65210">
        <property type="protein sequence ID" value="CUO65210"/>
        <property type="gene ID" value="ERS852471_01972"/>
    </dbReference>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="515" mass="58421" checksum="66B44D15FA0D5F64" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H028</accession>
    <name>A0A174H028_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
            <ecNumber evidence="3">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acr1</name>
        <name evidence="3" type="ORF">ERS852471_02034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68173">
        <property type="protein sequence ID" value="CUO68173"/>
        <property type="gene ID" value="ERS852471_02034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO68173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="28670" checksum="93D4AAB73CF822E9" modified="2016-09-07" version="1">MMKNKIALITGASSGIGKEFAKLHAARGGDLVIVARSKDKLNELKKDLENKYNIKVMVIVKDLSLSNAAQEIYDEVKAANITIDYLINNAGFGGRGEFHVRSMEQDIQMIQVNVITLTRLTKLFLPDFVKRGDGRILNVSSTAAIMPGPLQAVYYATKAYVTSFSNAVWQEIKGTGVTITTLMPGAMDTGFAKASDMSNTPLFSKTVSPVDVAKDGYEGMLKGKLNVISGVSLLQRMFLALTPFTPKKIMMKQIYEMQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6X1</accession>
    <name>A0A174H6X1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266279.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69106">
        <property type="protein sequence ID" value="CUO69106"/>
        <property type="gene ID" value="ERS852471_02060"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1331839at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29884" checksum="F4745E5D52372702" modified="2016-09-07" version="1">MLVDREKALRAFNDYVEKYDINNEKIRLKTEHTYRVCELCEKIALSLKLSDEEVNIAWLTGLLHDVGRFEQVKRYGTFNDPKSVNHAKLGSEILFNDGIIRNFIEDMSEDNLIKCVIDNHNAYRIEEGISERYKTFCNILRDADKIDIFKVNAIIPAEEIYNVTNEELCSSEVTKEVLDNFKRRDTILRTLKKTAVDNVVGHISLIFGLVYDESIRTVERQGYLKELIEFKSENESTNKQFDEIRKIVREYIEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HB34</accession>
    <name>A0A174HB34_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266391.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72122">
        <property type="protein sequence ID" value="CUO72122"/>
        <property type="gene ID" value="ERS852471_02122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO72122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="75" mass="8930" checksum="057A6F8CBE3488FB" modified="2016-09-07" version="1">MKVKIFNGKNFRELEDRINNFIKDKRVISINSETTFCETRGLIWSVLIVIILYEEIDHCGYLDAKSLINFEKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HM21</accession>
    <name>A0A174HM21_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75261">
        <property type="protein sequence ID" value="CUO75261"/>
        <property type="gene ID" value="ERS852471_02211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="1">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="76" mass="8222" checksum="E0AE6531EA98CE38" modified="2016-09-07" version="1">MKSEDATIVALKGQYEDVLNHIVGKDITTVVDELYTPENITKDIDGFTAATVRSGKIISAINDALNRGVYALPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPI7</accession>
    <name>A0A174HPI7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">ERS852471_02216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266547.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75436">
        <property type="protein sequence ID" value="CUO75436"/>
        <property type="gene ID" value="ERS852471_02216"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO75436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="513" mass="56894" checksum="6522222D28CA97E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQ00</accession>
    <name>A0A174HQ00_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsiV</name>
        <name evidence="3" type="ORF">ERS852471_02261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266638.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77033">
        <property type="protein sequence ID" value="CUO77033"/>
        <property type="gene ID" value="ERS852471_02261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="156"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO77033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="242" mass="28254" checksum="C349B3B2BCA6D2C1" modified="2016-09-07" version="1">MKWLKQAILVIFMLSTVFGSCPQSMLITRGYSNIYPQMTIVDKVYKSKNDYLQIDVTIPQIKNLPNEDKEKNINNLITTWTEEWINDAKYIADEYFKNGTPPLNPYQLNAKYKVTNLKKVISLYIDYYQYTGGAHGVTTRKSYNIDETTGDILTLKDLFNSEYNYKDKIDSNIKNEINKNSDIYFTGKEGFNGIDEKTKFYIEDGNLVIYYGQYEIAPYATGIPEFRMPINMFEENFKYGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRE9</accession>
    <name>A0A174HRE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266572.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75907">
        <property type="protein sequence ID" value="CUO75907"/>
        <property type="gene ID" value="ERS852471_02229"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123545at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="16791" checksum="33BBAC596FD45309" modified="2016-09-07" version="1">MKKVIWSIILTILLIGLVGCQIKTEDNTHKDSLSVEIIATNDANSYKGMPITLKPKAIGEYDKEIQYHWILKSDDDVEGFIVPEKGPQKEIINSGEPVELGLFKEVSWVEGTVIEFKVELQIEDKETSKIIATNKITIENNQGTYSIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTV5</accession>
    <name>A0A174HTV5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">glnS</name>
        <name evidence="12" type="ORF">ERS852471_02280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266667.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77641">
        <property type="protein sequence ID" value="CUO77641"/>
        <property type="gene ID" value="ERS852471_02280"/>
    </dbReference>
    <dbReference type="OrthoDB" id="142899at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="340"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="552" mass="63751" checksum="3924A65D696821AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HXP5</accession>
    <name>A0A174HXP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of Uncharacterized Function (DUF1540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266665.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77595">
        <property type="protein sequence ID" value="CUO77595"/>
        <property type="gene ID" value="ERS852471_02279"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1787593at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="10966" checksum="7A7F06FA614F2B9B" modified="2016-09-07" version="1">MTNLICNVESCIHNNSACCCKEGITVGGSEASSASATCCDSFEEKHGAFTSNFEAPHGSLNVQCEAENCTYNENRMCAAEAIHIAGMNACTTGETECNSFVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZE3</accession>
    <name>A0A174HZE3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-K factor-processing regulatory protein BofA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266693.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78717">
        <property type="protein sequence ID" value="CUO78717"/>
        <property type="gene ID" value="ERS852471_02296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010001">
        <property type="entry name" value="BofA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07441">
        <property type="entry name" value="BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02862">
        <property type="entry name" value="spore_BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO78717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="82" mass="9160" checksum="CE71AACDF0E897C3" modified="2016-09-07" version="1">MDMELIIYGLVGLALLFLVIKLLKWPIKILINGLVGIVLLYLTNYIGAYFNFSLVINPVTALIAGFLGIPGIIFLIIFKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZW8</accession>
    <name>A0A174HZW8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsR</name>
        <name evidence="6" type="ORF">ERS852471_02354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266778.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80542">
        <property type="protein sequence ID" value="CUO80542"/>
        <property type="gene ID" value="ERS852471_02354"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO80542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="80" mass="9341" checksum="97475041401CFF1B" modified="2016-09-07" version="1">MRDMKRSGKMRRSKRKVCAFCVDKAESIDYKDVAKLRKFVTERGKILPRRISGTCAKHQRQLTDAIKRSRNIALLPFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I0Q3</accession>
    <name>A0A174I0Q3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class V aminotransferase</fullName>
            <ecNumber evidence="4">1.12.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266689.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78645">
        <property type="protein sequence ID" value="CUO78645"/>
        <property type="gene ID" value="ERS852471_02294"/>
    </dbReference>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="358" mass="40320" checksum="D1DCB87653AC5FDC" modified="2016-09-07" version="1">MHKKLFIPGPVEVKKEVLEKMATPMIGHRSKEASELQKSISDKMRKLFYTESEILLSTTSGSGLMEGAIRSCTAKRAAVFSVGAFGKRWYEMAVSNNVPADIYEVDKGKALNVNEIDKALSTGKYDFLTVTHNETSTGIMNPIEEISEVVKKYPEVVFAVDAVSSAAGSKIEVDKYGIDICITSTQKAIGLPPGMAICTFSDKAIKNAEKVKFRGTYLDLLALYKYIKKKDYQYPSTPSISHMYALDYQLDYILNVEGLENRFARHIEMANVVREWGKKYFELFPDERYISNTLTTIKNNRNISVANLNKELGRRGFQISNGYGDLKEKTFRIAHMADCTVEDINELLSHINDILQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFU6</accession>
    <name>A0A174IFU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolS_2</name>
        <name evidence="2" type="ORF">ERS852471_02429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266912.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83955">
        <property type="protein sequence ID" value="CUO83955"/>
        <property type="gene ID" value="ERS852471_02429"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="321" mass="36479" checksum="ED6C0D395BC795AA" modified="2016-09-07" version="1">MKKRILGRDLEVSAIGLGCMGMDHAYGAPADRNEMIKLIRKAVDLGCNFFDTAVVYGESNEELLGNALEIYNREEVVIATKFGIIGQSVIDGKPLNILDSKPESIRNQLEGSLKRLKVDYIDLYYQHRIDPEVEPEDVAKVMKELIEEGKIKYWGVSNAPIDYIRRAHAICPITCVENQYSMVFREAENELFNVLEELNIGFVAYSPLGNGFLSGKYNKDTKYQEGDFRNNMKRFSLEVMERNQVLLDLLKEIAERKNATSAQIVLAWELAQKEYIVPIPGTTKLHRLEENLGGVAINLTREEVQEINEALDSIEIDESHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ILF1</accession>
    <name>A0A174ILF1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
            <shortName evidence="9">ECF transporter T component EcfT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cbiQ1</name>
        <name evidence="9" type="synonym">ecfT</name>
        <name evidence="10" type="ORF">ERS852471_02525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the energy-coupling factor EcfT family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267071.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88212">
        <property type="protein sequence ID" value="CUO88212"/>
        <property type="gene ID" value="ERS852471_02525"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01461">
        <property type="entry name" value="EcfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024919">
        <property type="entry name" value="EcfT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO88212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="29708" checksum="B2BB83CC08C6C16A" modified="2016-09-07" version="1">MIKDITIGQYLPGDSFVHNLDPRTKILLSILFIVCLFVIDKFVGYAFVVAFLALVVYISQIPPRYLYKGLKPVFFLIILTAVLNIFMLRGGALLFEFGFIKIYEEGIRTAVFMAVRLVLLIMGTSVLTLTTSPIELTDGIERLLRPIGKEIAHELAMMMTIALRFIPTLIDETDKIMKAQKARGADFETGGIIQKAKSLIPLLVPLFISSFRRADELAMAMEARCYRGGAGRTRMKVLKFSSRDFIAFGVFSLLVIASFAIRFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IN20</accession>
    <name>A0A174IN20_9CLOT</name>
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        <submittedName>
            <fullName evidence="4">Elongation factor Tu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tuf</name>
        <name evidence="4" type="ORF">ERS852471_02489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86708">
        <property type="protein sequence ID" value="CUO86708"/>
        <property type="gene ID" value="ERS852471_02489"/>
    </dbReference>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO86708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="129" mass="14133" checksum="F3AEDECFD43FCC7C" modified="2016-09-07" version="1">MAKQKFERSKPHVNIGTIGHVDHGKTTLTAAITTVLANRGFAEAFNYADIDKAPEEKERGITINTAHVEYETEHRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLASRXQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IRV9</accession>
    <name>A0A174IRV9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267133.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90084">
        <property type="protein sequence ID" value="CUO90084"/>
        <property type="gene ID" value="ERS852471_02559"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1963856at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="19518" checksum="B9DA12BB9D97123A" modified="2016-09-07" version="1">MKKGVKLNNVIFPIWMMWIFPPLALLALIGNFVIDSLVILVAFAIFKVVKSTGLSMGQLYKKSIFKVWIFGFLGDIVGAIMLFVTMLILETGEGANDIISAICYNPFSNIIGLIIVVAAVVLAVLLIWTFNYYIVFNRLIDDSKIRMRVAITIAIVTMPWTYLIPTQWLYKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IS77</accession>
    <name>A0A174IS77_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LSU ribosomal protein L14E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87789">
        <property type="protein sequence ID" value="CUO87789"/>
        <property type="gene ID" value="ERS852471_02516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO87789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="103" mass="11884" checksum="981BA334F2B21537" modified="2016-09-07" version="1">MTKVIIEVKNLQNNDLIGKVVLSTCGRDKDHYYVIVKKLNDDYYLLSNGRTKTIQMPKKKKLKHFIVLEDVNDEIKASIISQHRGADLKIKKFLKEKGIVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IV48</accession>
    <name>A0A174IV48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267183.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91254">
        <property type="protein sequence ID" value="CUO91254"/>
        <property type="gene ID" value="ERS852471_02587"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728504at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO91254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="29870" checksum="FB80628EF9647DB4" modified="2016-09-07" version="1">MEISQSFWNSSIDEIKNGYIEEAGSIKCLVCGEVFTIGRIYEIDGKFYDARKTAEIHMEEKHNSMLNYLLNMNPTFTGISEVQKNVLELMAMGLSDKEIAQRLKVANSTIRNHRYKLREKEKQAKVFLAMMDLLENNTSRNINILENTVICDPHKTATTLDDRFNITDEEKVKVIENYMDENKRLKSYPAREKKKVIILEEICKNFKCGKKYSEKEINRILQRIFDDYVTLRRALIEYGFLDRSNDCSEYWVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IXP5</accession>
    <name>A0A174IXP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267147.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90387">
        <property type="protein sequence ID" value="CUO90387"/>
        <property type="gene ID" value="ERS852471_02566"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2195168at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO90387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="11714" checksum="50C809D93084CADE" modified="2016-09-07" version="1">MDIFKILNNDTTGLTDEEKAFAEGFNYDLREKIMAELVEHEINEFIKELKEDIDGFKEKVENIFVNGKKGYKDMPTKTLIDIYLSKMNEGDFINLIESING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J5K2</accession>
    <name>A0A174J5K2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ntpB</name>
        <name evidence="4" type="synonym">atpB</name>
        <name evidence="7" type="ORF">ERS852471_02676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267342.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95024">
        <property type="protein sequence ID" value="CUO95024"/>
        <property type="gene ID" value="ERS852471_02676"/>
    </dbReference>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="5">
        <location>
            <begin position="131"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO95024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="50924" checksum="C6DD72A6AABD65F5" modified="2016-09-07" version="1">MLREYRTVTEVVGPLMVVEGVSGVKFDELVEVEIQTGEKRRGKVLEVNGSRAMVQLFEGSSGINLKGTKVKFLGKPLQLGVSEDMLGRVFDGMGNPIDKGPKIIPEAYKDINGEAINPVSRDFPAEFIQTGISAIDGLNTLVRGQKLPVFSAAGLPHAQLAAQIARQAKVLNSDSNFAVVFAAIGITFEESQFFVDEFKKTGAIDNAVLFMNLASDPAIERIATPRMALTAAEFLAYEKDMHVLVIMTDITNYAEALREVSAARKEVPGRRGYPGYLYTDLSTLYERAGRIRGRKGSITQIPILTMPEEDKTHPIPDLTGYITEGQIILTKELYKKGVMPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFSAYAQGKQAKELSAILGESALSDTDKKFAKFAEAFEEEYVSQGFETNRTIEETLNLGWKLLKILPKTELKRIRDEYLEKYMLREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6G3</accession>
    <name>A0A174J6G3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavoprotein</fullName>
            <ecNumber evidence="3">1.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fprA1</name>
        <name evidence="3" type="ORF">ERS852471_02683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267354.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95292">
        <property type="protein sequence ID" value="CUO95292"/>
        <property type="gene ID" value="ERS852471_02683"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="249"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO95292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="390" mass="45009" checksum="1BE541C382A10A10" modified="2016-09-07" version="1">MAVEQLKESIYWIGVKDPELRIFDIIMETKKGTTYNSYLINDEKVAIFDIVKNGFYNEFKENIKSIIGEKKIDYVVVHHTELDHSGALKDLIKDYPEVKIVGSRATLKYLKDILNCEFNAREANEEINLGNHTLSFISAPNLHWPDTMFTYVKEKNILFTCDFTGSHFCPEGSMTCELNDEYFSEMKYYYDCIMGPFPKYVNLGLEKIKDLKIDMIAPSHGPIHVREIDKILNLYKEWSKEVEVDENKVEIFYISAYHNTEMMANFFKKKLEDKGFKADVTEITTIPLEESIEKISKAKGFLIGSPTINKDAVKPAWDLLSLVSAITNRDKVAMAFGSYGWSGEGVPMLTERLKSLKIKTAPGYKFCFVPSEEKYEEAEDYLDEFIELMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6Z5</accession>
    <name>A0A174J6Z5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermostable carboxypeptidase 1</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
            <ecNumber evidence="2">3.4.17.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yxeP_2</name>
        <name evidence="2" type="ORF">ERS852471_02654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EC" id="3.4.17.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267301.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94056">
        <property type="protein sequence ID" value="CUO94056"/>
        <property type="gene ID" value="ERS852471_02654"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="189"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO94056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="393" mass="43188" checksum="9BA85D4985FB30CA" modified="2016-09-07" version="1">MDFKNDIIDIKDEIVRLRRMFHMKPELGFEEYETSKEIKKYLNQEGIAYESYAKTGVCGIIRGNLESNKERVIGLRSDIDALPIDENNKCSYKSTVKGKMHACGHDGHMAILLGVAKILNKNRDLFGGTVKLIFEPAEETKGGSRFMIKEGVLKNPDVDIMCGLHVDENINSGQIEIKHGAVNAASNPFKIEVIGIGGHGAYPAASIDPIVIASNIVTALQSIVSREVNPLNPAVITVGSINGGTAANIIPEKVTLTGIIRTLNKNDRQLVTRRVKEIAEGIGLTLRGKVNIEIEESYPMLINDKNAVSKLKNAAIKIIGEENVLEQEYPHMGVESFAYFANEVPSVFYFLGCRNEKKGIIHPAHSSLFDIDEDALVIGVAIQCQIVLDYLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JKC7</accession>
    <name>A0A174JKC7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Diacylglycerol kinase/PAP2 family protein</fullName>
            <ecNumber evidence="13">2.7.1.66</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dgkA</name>
        <name evidence="13" type="ORF">ERS852471_02729</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.66" evidence="13"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97600">
        <property type="protein sequence ID" value="CUO97600"/>
        <property type="gene ID" value="ERS852471_02729"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893988at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009038">
        <property type="term" value="F:undecaprenol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="12">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO97600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="233" mass="25428" checksum="87A657EDCF778284" modified="2016-09-07" version="1">MGVRKLLESFNHAINGIIYAIRTQRNMKIHTIGAVIVLLACFFVDLSKVEFLILALTITSVFVAEMINTAIEAAIDLNTNYYHPLAKVAKNTAAGAVLITAINAVLVGYIIFWDKFEEISYGVIHKMKNSEPYMIFIALVIVSLATVIIKAIYGEGTPLKGGMPSGHSALAFSLSTAISLITEEPICIILAYLMAFITAQSRVDSEVHTVFEVIVGALLGVLLTLFIFTIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JKS4</accession>
    <name>A0A174JKS4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">feoB_2</name>
        <name evidence="14" type="ORF">ERS852471_02789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267542.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00322">
        <property type="protein sequence ID" value="CUP00322"/>
        <property type="gene ID" value="ERS852471_02789"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="13">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP00322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="586" mass="64800" checksum="2F2F5150FA7AB384" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JL99</accession>
    <name>A0A174JL99_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative P-loop kinase or ATPase distantly related to phosphoenolpyruvate carboxykinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267551.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00554">
        <property type="protein sequence ID" value="CUP00554"/>
        <property type="gene ID" value="ERS852471_02794"/>
    </dbReference>
    <dbReference type="OrthoDB" id="145977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP00554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="581" mass="67515" checksum="60BF634D6899A632" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JTN8</accession>
    <name>A0A174JTN8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsC_2</name>
        <name evidence="4" type="ORF">ERS852471_02793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267549.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00510">
        <property type="protein sequence ID" value="CUP00510"/>
        <property type="gene ID" value="ERS852471_02793"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="70"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP00510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="233" mass="26322" checksum="4E409B1DA1F111F8" modified="2016-09-07" version="1">MIIKGILYGAYMLNVRVKAIKHSWIKKYKGQEEADKYAQKTAYLWAKYTIKTIGIDLEVKGLENIPDEACVFIGNHTSILDIPIMFYTIDRLVGFVAKKEMLKAPVIGTWLEKAHCIPLDRENPREAIKTINYGVELLKKGYSLAIFPEGTRSKDGNIGEFKKGSLKLATKAKAPIVPIAIDRAYTSFEKDKKFKPSKIKVTFGNAISTAELTKEEEKTLNEDVRNIIKSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JUV0</accession>
    <name>A0A174JUV0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rsmI</name>
        <name evidence="8" type="ORF">ERS852471_02850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267663.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03553">
        <property type="protein sequence ID" value="CUP03553"/>
        <property type="gene ID" value="ERS852471_02850"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP03553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="31982" checksum="A2C2F751A7361CE1" modified="2016-09-07" version="1">MSLGKIFLVPTPIGNLKDITLRALEALENADEIAAEDTRQTLKLLNHFNIKKPLFSYHQHNEQGKSDDIIEKLKDGKNIALVTDAGTPGISDPGSVVVQKCIEQDIPFEVLPGATAFTTALVYSGLDTTKFVFRGFIPRENKDRKSLMEEVKDKRETVIFYESPHRLIETLDFLNKSLGNRRIAVCRELTKLHEDIFRGTIEEAYNWFVANRPRGEFVLVIEGKTDSEIRAEKEEAFANISIEDHLKKLIDTGISKKEAIKVVSKERDLPKKDVYKIAIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JYM1</accession>
    <name>A0A174JYM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxyl-terminal protease</fullName>
            <ecNumber evidence="6">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctpB</name>
        <name evidence="6" type="ORF">ERS852471_02830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267627.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02698">
        <property type="protein sequence ID" value="CUP02698"/>
        <property type="gene ID" value="ERS852471_02830"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="117"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP02698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="419" mass="45476" checksum="0C3EF8BBFC2863FE" modified="2016-09-07" version="1">MEDLNRGENNSKKGGKKALRIGLIVVVLLASHGLLLYLGNVLAINGVIFKGAPQKAIADLSSVGDTSKYKYLFTLRDLIYSKYDGDIDDQKLLEGAMKGMASAVKDPYTVYMTQEEFDTFMESSQGSFYGIGAQLGVRDNKVTIIAPIEGSPAEEAGLKAGDVILKVDDYEVVDLNTEAVVARVRGEEGQPVTLTIQRGDGEPFEVEIVRAEIKNESVKGEMLDDSTAYVQITTFSDEEVSQKFTDEINELKAQGMKKLILDLRGNPGGYLDQCVEIASHFIKEGEIVTYTIDKYDQKVVSKSKGGDLLGMPLVVLVDGGSASASEVVTGALRDHDAATIIGTTTFGKGIVQQLISLPDNEGGLKVTTSKYYTPDGENIHGTGISPDITVEIPQEVLEVEYSRNIDPQFQKALEVIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZM6</accession>
    <name>A0A174JZM6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SagA protein</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03636">
        <property type="protein sequence ID" value="CUP03636"/>
        <property type="gene ID" value="ERS852471_02852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025640" evidence="3">
        <location>
            <begin position="42"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="307"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="164"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP03636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="420" mass="46885" checksum="8B2E9DDD708B6F84" modified="2016-09-07" version="1">MVMCYKRKGGRSEDQAKMRKKILSAILATTIIASFSMPAFATPEQDVIENQQEYDRLTQKIDEINGEIYALNGQIEPLLETIENNQKQMDDIKVEVTNTEKEIEAAKEKIQKTEEVLGKRVRELYKSGGQASYLTLIFSADSFNDLLTKVEATSRLINIDKKMVKELNDKQEKLDNKIKSLDEKNAELAKINEETSKTLSEFEEKKAEQEKLIEEAKAEQAIFERDYLAVSERKLIQYQIGVIQDSSSSLDELQSAISQLRNIRDNQIKSSIVEEEINEYIETAKVRVAEIEAEQAAANKPNRGEVSATGNAIVDFAYGYLGSPYVWGATGPTSFDCSGFTSFVYRNAAGVEITRTTYSQMGVGTAISYDQLQPGDLVFTYGGDHVGIYVGGGSYIHAPTEGDVVKVSPVTSFYTARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K3X8</accession>
    <name>A0A174K3X8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP06732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267789.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06732">
        <property type="protein sequence ID" value="CUP06732"/>
        <property type="gene ID" value="ERS852471_02919"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP06732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="232" mass="25887" checksum="343F9865C6DBE17F" modified="2016-09-07" version="1">MKSDRIFWGVFLLLGAVFLLVSKLGYFSDINIFSLLFTILLVAIILKSIIKLSFPGILFPLAFIGIIYDDKLGITAITPWTILFVALLGSIGLSLIFNKKPKWDKANYKWDGNATETIDIEDEGHIKLETSFGSSIKYINTDKFEYANLKCSFGSMNVYFDNAIMEKENAVVKIDVSFAGMQLYIPRGWNVINNTSASFGAVEEKNRIDAVKTNTLTLIGGISFAGVEIFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8Z3</accession>
    <name>A0A174K8Z3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BFD-like [2Fe-2S] binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267864.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08543">
        <property type="protein sequence ID" value="CUP08543"/>
        <property type="gene ID" value="ERS852471_02962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="135" mass="14866" checksum="9FB61BAF68E19217" modified="2016-09-07" version="1">MRNNKIRKIYEVINENGRGLNLHEIKAMTGIGNGYNSTTIDTIPVTTTNHKSEKIYDVVTNIKGKVNLHQIKAQTGAGNGHKHSNIVDVINNISNDIAEACSHKSHKINEVLNNSRNLNLHEIKALTGAGSGYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KBP9</accession>
    <name>A0A174KBP9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrichrome ABC transporter substrate-binding protein FhuD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fhuD2</name>
        <name evidence="3" type="ORF">ERS852471_02938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267823.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07507">
        <property type="protein sequence ID" value="CUP07507"/>
        <property type="gene ID" value="ERS852471_02938"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025908" evidence="1">
        <location>
            <begin position="27"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="34533" checksum="E1C7E3FE9BFDC5E7" modified="2016-09-07" version="1">MKKNLLKTLVVSCVTALMFMGCGAKTEDGANNVSENTVTVTDVRGEVEIPADPQRIVDLSGNSDILSILGYKVIGTANSDAYDYTKFPAYLEETLKGAEILGYSMQDTMDVEAVMNLNPDLIVISTVQEKMYDQLSEIAPTVMIQLEALNWKDDVKALAEVFNKEDVANEWIANYETKAKEAGDKIKAEYGEDTTYLSFLASGGQFFIFDGAGFGDVLYNDMGLAKPEGMPEQTDISLPVVTYEGLASIKADYIFLIATAEDLAQLESNAIWNNLPAVKEGHVVVLDSSPYFNQGYSSIGRELLVDEIGEMLNGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KD02</accession>
    <name>A0A174KD02_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulase M and related proteins</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ysdC_5</name>
        <name evidence="9" type="ORF">ERS852471_02929</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267807.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07129">
        <property type="protein sequence ID" value="CUP07129"/>
        <property type="gene ID" value="ERS852471_02929"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP07129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="359" mass="39320" checksum="B0239BE00D0CBBBC" modified="2016-09-07" version="1">MINLNVLKELSDAFGPSGFEDDVVEVIKKHCKDMIVENDAMNNVFAKLKNNSGKKITVMLDAHTDEVGFMVQAINDNGLLSIVKLGGWHNTTIPAHTVYIKNRDGELIRGITTSKPSHFMTAAEKSSNALEIEDIFIDVGASSKEEVIDIFKIKVGDPVAPNVEFDFNEKTGVCFGKAFDNRVGCFCIIQTLKALADIIDLEVDVVGAFAAQEEVGIRGAQITTEVVNPDLAIVFEGSPADDLYYSKNISQGALKKGTQIRNLDQGYIANPLFIRYAEDIADKNSIKYQNAVRRGGSTDAAKISLGNKAVPCLVLGIPSRYVHSHYNYCAKEDIEASVSLAVEVIKNLNEESINKIMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KRY5</accession>
    <name>A0A174KRY5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitroreductase family protein fused to ferredoxin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_03045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268035.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12618">
        <property type="protein sequence ID" value="CUP12618"/>
        <property type="gene ID" value="ERS852471_03045"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="273" mass="31124" checksum="16EFAF85872FE335" modified="2016-09-07" version="1">MFKVDRHKCIACMQCIKDCPARVISLKDGKADINNEGCIKCGHCIAICPVDAVSTDDYNMNEVIPYDKETFSVDADNLLNFIKFRRSVRRFKNKEVEKEKIMKIIEAGRYTQTATNSQDVSYIVVTEKLNKLKELAYESLKRKGEYILANLTPETEHLKRYANMWLYSYNEFKKDPIKNDRLFFNAPLSIFVTSPNPLNGGLACSNMELMTDALGLGTFFSGFLQIAAQDNKEILDLLGIKDSKLIISCLVIGYPDVKYQRTAPRKTANINWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L2W6</accession>
    <name>A0A174L2W6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268192.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17181">
        <property type="protein sequence ID" value="CUP17181"/>
        <property type="gene ID" value="ERS852471_03135"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="363" mass="41735" checksum="D26FDF31AE0B9F9C" modified="2016-09-07" version="1">MTKFIVLHVGYNSGNKASGAEVAITKSLTFQQKYCICALLNLSSKKINEFTSYSYEEFKMIELLPIPFNKPNIVVFHELYRSEFLKIYRECKKKHIPYIIIPHGGLSYTAQKTKAIKKKVANLFLFDSFFKSADAIQFLSLAEKINSRIFSKQETLILGNGIDKPKVLNLQKDEKKLIILYIGRYDIHFKGLDVLLDACRRCKDYMRDKNIIIKMYGTGSNKDEEYLRNYVETNMINDIVNINGPIYDEEKIREYQKANYFIQTSRSEGQPMGILEALSYGTPIIVTPGTTLAEDTKKLSMGITCSLDEYSISDAIKRAYSNKENIGQMSNRAKKYISENFDGDNIAVKTIERYKILYEKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LB46</accession>
    <name>A0A174LB46_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268238.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18650">
        <property type="protein sequence ID" value="CUP18650"/>
        <property type="gene ID" value="ERS852471_03162"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923113at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="12255" checksum="E81B5BB29904F9D9" modified="2016-09-07" version="1">MKKVYLKNQLKGYPIEVISNVLDVINVLGENYGANRDIEKDLGGYIVIAENIVVIEMLKKDKLQGLIPEYTDIIECSEGVNWTSSLFLLSSDFAIVVVTTEELSKFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LE61</accession>
    <name>A0A174LE61_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoVE</name>
        <name evidence="8" type="ORF">ERS852471_03207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268320.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21211">
        <property type="protein sequence ID" value="CUP21211"/>
        <property type="gene ID" value="ERS852471_03207"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP21211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="398" mass="43309" checksum="FE50EFEF603F9E23" modified="2016-09-07" version="1">MSTIDLQKRIKYNKSKKKKKKKTKITIDRDNGVYVAVILLVLIGLLLVFTSSSYYALYEQGDLYFFIKKQAIWAVIGLGFMSFFARVDYHFLRKLTWPLAIGTLGLLVLVLAIGKEINGAKRWLEFGGLSIQPSEIAKYAVVFVLAHVIVKMGKEIKTISKGIVLPLAIGAAFAVLVLAEKNLSITVVIALVTYFMIMVGGANIRVLIGLIPVGFLAGLGLIVIEPYRLERLTTYLNPWADQSDSGYQLVHSLMAIGSGGVTGQGLGNSMQKALYMPEPHNDFIFAILAEEFGLLGCIFVIGLFIFFIISAIKVAMRAKDIYGRLLAIGITLVIAIQAIINIAVVTGSIPVTGVPLPFISTGGTSLLINLVAMGVLLNIAKQGKKSKVDAEDKVRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LPA3</accession>
    <name>A0A174LPA3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NifU-like protein involved in Fe-S cluster formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268403.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23585">
        <property type="protein sequence ID" value="CUP23585"/>
        <property type="gene ID" value="ERS852471_03253"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1066272at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP23585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="24651" checksum="ADC119B4B3BBC402" modified="2016-09-07" version="1">MMYSKEVEEMCVVAKGANHACAPIPVEGRWVQATQISDISGLTHGIGWCAPQQGGCKLTLNVKDGVIQEALVETIGCSGMTHSAAMASEILPGRTILEALNTDLVCDAINTAMRELFLQIVYGRSQTAFSEGGLPIGAGLEDLGKGLRSQVGTTYGTLDKGPRYLEMAEGYITKIALDEDNEIIGYKFVHLGKMMEMIGKGMDANEALEKAAGQYGRVADAVKLIDPRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LPI7</accession>
    <name>A0A174LPI7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugative transposon site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002334812.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24636">
        <property type="protein sequence ID" value="CUP24636"/>
        <property type="gene ID" value="ERS852471_03269"/>
    </dbReference>
    <dbReference type="GeneID" id="60291855"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP24636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="540" mass="62599" checksum="6A0FAA7492B3C752" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M042</accession>
    <name>A0A174M042_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssuB</name>
        <name evidence="5" type="ORF">ERS852471_03327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000046">
        <property type="protein sequence ID" value="CUP28476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268515.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28476">
        <property type="protein sequence ID" value="CUP28476"/>
        <property type="gene ID" value="ERS852471_03327"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP28476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="24380" checksum="2D2627A1495BF3FE" modified="2016-09-07" version="1">MFIKDVNVKYDNKVIYNNFTIEFEDEKINCIVGSSGCGKTTLLNCICEKLIKKNIKVAYVFQEDRLLPWKNIFDNLKLVIKSKCGKEEVNNRIEDILNVLEISETKFLYPNELSGGMKQKVNIARALIYDFDVLLLDEPFRSLDMKIKNKVIDLIRTINKEKKTTIILVSHDKDEIKSLTDRVFLLKGSPVEIIEKGNKTIVDNIFSSIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRK0</accession>
    <name>A0A173XRK0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262805.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53556">
        <property type="protein sequence ID" value="CUN53556"/>
        <property type="gene ID" value="ERS852471_00087"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2008532at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="17101" checksum="05B36C25DC4E8E93" modified="2016-09-07" version="1">MDKSEYIEELSKIEGLVSICQFGSYGTEYWMEDVSDIDLVIVTAPDKNFMYTLKIEDDILELAKKFYKYDDIHLTFVLFNEFSNKYARIAVDSDNKFIINDEKWFDFQHYVCKYARNNENLERTLKIDEQFSYFGRIIDESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXN5</accession>
    <name>A0A173XXN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate uptake ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_1</name>
        <name evidence="7" type="ORF">ERS852471_00147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262916.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56444">
        <property type="protein sequence ID" value="CUN56444"/>
        <property type="gene ID" value="ERS852471_00147"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN56444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="32352" checksum="C96B3EBD0CB4B61F" modified="2016-09-07" version="1">MLKKGRKGYIYLLPALIILGVFVFYPIITTIVGSFDETKAPGFVFGFDSYRYLFQDKRFIQSLINTCIYAAVVPALSVGISLLLANSLVNIKNEKVRGVFQSIYFLPYVTSLVAIGVVWSWLFNSEYGIINYLLGLVGINPVNWLNDPKYAMLALIIFAVWKSLAFNTLILTTGIASINPQYYQAAKIDQATDGTIFRKITIKLVSPMIVYTYIISLIAAFKVYTEVYVLFGGRTLDGAVSTVVRYIIDRFYGDQDFPLAFAAAVVLLIIILTVTFVQRTISRNKVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y343</accession>
    <name>A0A173Y343_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262966.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57676">
        <property type="protein sequence ID" value="CUN57676"/>
        <property type="gene ID" value="ERS852471_00173"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879862at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="110" mass="12926" checksum="E45E18072DABE211" modified="2016-09-07" version="1">MTDRVPKEYISKIAKASTYFAFKNGPIKEMLKDNKLSEEDLKVIQKYMDDHLAYLYTVLLEENNLKKFDLIVNTMSKFYVNDSEEVMINDDGFDKFYDSLFPKSSNITIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4K1</accession>
    <name>A0A173Y4K1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mutS_1</name>
        <name evidence="7" type="synonym">mutS</name>
        <name evidence="11" type="ORF">ERS852471_00191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263002.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58593">
        <property type="protein sequence ID" value="CUN58593"/>
        <property type="gene ID" value="ERS852471_00191"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15991at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="826"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="613"/>
            <end position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN58593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="892" mass="100776" checksum="D91D3A17D4B12828" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4V8</accession>
    <name>A0A173Y4V8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262968.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57718">
        <property type="protein sequence ID" value="CUN57718"/>
        <property type="gene ID" value="ERS852471_00174"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1966013at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="16015" checksum="B10E6A906B620220" modified="2016-09-07" version="1">MYIAFGNRVVDSKDFIKVIEENTEFKVIKDMSKGSKREDIVALNLSIDISELNEVISENYKIEDLDEDTLFEEYMTISEEIGYEIEEYLPEDAIVKFQAYKWDPSDNDVKAIIVIVHEELGERKAMDLIKRLLKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9A0</accession>
    <name>A0A173Y9A0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263037.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59817">
        <property type="protein sequence ID" value="CUN59817"/>
        <property type="gene ID" value="ERS852471_00213"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1751319at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="129" mass="15036" checksum="024477C5E961D069" modified="2016-09-07" version="1">MKDQRNRLVVPRNIVNTKMLYTFYILKELSKGEVVFGNKILSTFKDVFENCSHPFPVSSSTIYETLYSLEEKGYVVSSWTGDLVLNKRSKKFYSITDEGLNYYKTHIADYVNNIEKTKSTLDLIIKMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YI37</accession>
    <name>A0A173YI37_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hiran domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263125.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63604">
        <property type="protein sequence ID" value="CUN63604"/>
        <property type="gene ID" value="ERS852471_00247"/>
    </dbReference>
    <dbReference type="OrthoDB" id="614661at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN63604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="637" mass="75179" checksum="49F2F72870D76776" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM61</accession>
    <name>A0A173YM61_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur_1</name>
        <name evidence="3" type="ORF">ERS852471_00273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65014">
        <property type="protein sequence ID" value="CUN65014"/>
        <property type="gene ID" value="ERS852471_00273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="18098" checksum="88B7744D5705B72F" modified="2016-09-07" version="1">MGGISININELKENLKEKGYKLTPQRRAILDIIIEKEGQHLTAEEIYDEVKKRCPDIGLATVYRTVLLLEEVNVIYKLDLNDGCSRYELVHSDEEHRHHHLVCNKCKRVYEVQDDLLEELEERIEKTYKFKILDHSVKFFGICSECCDCNEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXE4</accession>
    <name>A0A173YXE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263279.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68200">
        <property type="protein sequence ID" value="CUN68200"/>
        <property type="gene ID" value="ERS852471_00331"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN68200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="166" mass="18733" checksum="4BAA81331D4D1494" modified="2016-09-07" version="1">MEVQFLDLLVKDGRKKAVDFSLDLEPIKFEGEIIKAIKPVKVEGQIVSRNDVLELEATIKTELELNCSRCLDTFIYPIDIDIEERFTNNKELQDEEGIIFVEGDTLDLSLIVENSIISTLPIKRLCAEDCKGLCSNCGANLNVDKCSCNNYDVDIRLAKLKELFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYL7</accession>
    <name>A0A173YYL7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">rnhB</name>
        <name evidence="14" type="ORF">ERS852471_00348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263303.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69084">
        <property type="protein sequence ID" value="CUN69084"/>
        <property type="gene ID" value="ERS852471_00348"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="87"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="30414" checksum="C8EFE717257D38C0" modified="2016-09-07" version="1">MKLLNSDIVALKFKDIKEEVANIDVSSSYKTAEFDSIVDLLLKDSRKNVNALGNKLLKEKNKILDEIKRVRAMYDFDKSFGDFNIIAGVDEVGRGPLAGPIVSCAVVLDLNVLDEQLLLWINDSKKLNEKKREELAEIIKEKALAYHIASCDSEEIDKRGIGVCNNAVFLEATNSLQIKPDLVLSDGYTIKGIDIPNKSVIKGDTKSANIAAASIVAKVYRDKLMKEYAVKYPYYAFEENVGYGTSKHIDGIKEYGPCKIHRMSFLKNILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZL4</accession>
    <name>A0A173YZL4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">acpP_1</name>
        <name evidence="7" type="synonym">acpP</name>
        <name evidence="11" type="ORF">ERS852471_00334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118133.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68355">
        <property type="protein sequence ID" value="CUN68355"/>
        <property type="gene ID" value="ERS852471_00334"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN68355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="76" mass="8738" checksum="591116D3148DF108" modified="2016-09-07" version="1">MFEKIRSIISEKLGIDEEEITMESAFIEDLNADSLDIVELIMALEDELEMEIPDEEAETFVTVADIVKFMKEHGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z2N0</accession>
    <name>A0A173Z2N0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-sensing transcriptional pleiotropic repressor CodY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">codY</name>
        <name evidence="10" type="ORF">ERS852471_00353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CodY family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263313.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69445">
        <property type="protein sequence ID" value="CUN69445"/>
        <property type="gene ID" value="ERS852471_00353"/>
    </dbReference>
    <dbReference type="OrthoDB" id="977877at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00621">
        <property type="entry name" value="HTH_type_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014154">
        <property type="entry name" value="CodY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010312">
        <property type="entry name" value="GTP_sensing_CodY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013198">
        <property type="entry name" value="GTP_sensing_HTH_CodY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40062">
        <property type="entry name" value="PTHR40062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06018">
        <property type="entry name" value="CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08222">
        <property type="entry name" value="HTH_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011572">
        <property type="entry name" value="GTP_sensing_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02787">
        <property type="entry name" value="codY_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CodY" evidence="8">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_CodY" evidence="9">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="28691" checksum="5CC8B5C6BCF44891" modified="2016-09-07" version="1">MSSLLDKTRKLNRILQKGGTEPVAFEDICALLSEVLCANVYIISRKGKILGHTFLENFECEIMRKYVVNDKMFPGIYNDDLLSASQTIANIKNKGLCVFEGEGQCPMKDKVSTVVPIIGNREKLGTLLLARFGEEFTDEDLVLAEYSATVVGMEILRAKQDELEEEARKKAVVQLAIGTLSYSELEAIEHIFNELEGNEGLLVASKIADKVGITRSVIVNALRKFESAGVIESRSLGMKGTHIKILNEKLIHELKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7Q3</accession>
    <name>A0A173Z7Q3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263381.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71506">
        <property type="protein sequence ID" value="CUN71506"/>
        <property type="gene ID" value="ERS852471_00391"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1546927at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="236" mass="26785" checksum="172F46E39E40E5B2" modified="2016-09-07" version="1">MKGKKINYQKIFNYFVLISLILTIIFLVWAMIAAPSVMNPSDPFARTKNDYVLILSQCILGVVAMFLPGVFERKFKIEIPSNMLILYTIFLYCAIYLGEVKSFYYNVPHWDTILHTFSGAMLGALGFSFVTLLNKTETVPINLSPLFVVIFSFCFAVTLGVFWEIYEFTFDGLLGLNMQKFALEGGVDLLGRAALVDTMKDLIVDCLGALIMSIIGYISLIYEKGWIEKLQLKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAW3</accession>
    <name>A0A173ZAW3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent butanol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adhE_2</name>
        <name evidence="3" type="ORF">ERS852471_00434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263456.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73572">
        <property type="protein sequence ID" value="CUN73572"/>
        <property type="gene ID" value="ERS852471_00434"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd08179">
        <property type="entry name" value="NADPH_BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034802">
        <property type="entry name" value="NADPH_BDH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN73572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="388" mass="42937" checksum="2B0F2278C75A0B18" modified="2016-09-07" version="1">MARFTLPRDLYHGKGSLETLKTIKGKKAMVVVGGGSMKRFGFLDRVENYLKEAGMEVRIFEGVEPDPSVETVMKGAEAMRDFEPDWIVAMGGGSPIDAAKAMWIFYEYPEFTFEQAVVPFGLPELRKKAKFIAIPSTSGTATEVTAFSVITDYKAKIKYPLADFNITPDIAIVDPDLAQTMPAKLVAHTGMDALTHAIEAYTASLRSNFSDPLALKAIEMVDEHLVNSYNGDEEARNLMHEAQCLAGMAFSNALLGIVHSMAHKTGAVFHIPHGCANAIFLPYVIQYNRIVCEERYADIARRIGLEGSNNAELTDALIERINKFNNDLNIPHSMKEYGVKEEDFKANLAFISENAVADACTGSNPREIDAETMARLFECTYYGNKVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZEF5</accession>
    <name>A0A173ZEF5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NlpC/P60 family protein</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ripB</name>
        <name evidence="5" type="ORF">ERS852471_00452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263491.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74604">
        <property type="protein sequence ID" value="CUN74604"/>
        <property type="gene ID" value="ERS852471_00452"/>
    </dbReference>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016820" evidence="2">
        <location>
            <begin position="30"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="292"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="371"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN74604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="519" mass="57221" checksum="CDB81F93646083F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZI83</accession>
    <name>A0A173ZI83_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yesO_1</name>
        <name evidence="3" type="ORF">ERS852471_00469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263519.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75473">
        <property type="protein sequence ID" value="CUN75473"/>
        <property type="gene ID" value="ERS852471_00469"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016909" evidence="2">
        <location>
            <begin position="30"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN75473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="453" mass="49891" checksum="5751E958AAA7765D" modified="2016-09-07" version="1">MKKLKLLTSLCLAATLTITSLAGCSSSNSSTGEESNDSSNSTEANTEVTDITEITWWAFPNFVTIDDEVGKYEKQIISDFEAKNPDVKVNLEMISFNGGGEKITAAIASNSAPDILYDAPGRIIDYGRQDVLADVDDMIKALNGDVSEEILQGCRVDDTYYMYPFNTTAFVMAANKTMFEEAGLLDLLPLEKEDRLWTIEEFEIALRGIKEANPDIIPVSFFSKSTAGDQGTRAFLANIFGGSIFNDDLSEYTLNSPEMVEALEWVNKCIDEGLIGAGSEGLTSSDAIDSFVQGKSAFTILYSTGLKANNAELKLGDFEDVLLPIPSPEGELGLEFLIGGYCVFDNQDDAKIEASKRFIDFACNDEEWQVKNIKATGTFSVRDSVKDLYDDEEMKAAEAFGKYLAPYYNTVPGFAEMRTFWFPSLQEITLKQTPIQEALDKLNENANSTLNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKK6</accession>
    <name>A0A173ZKK6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl xylan esterase</fullName>
            <ecNumber evidence="2">3.1.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cah_1</name>
        <name evidence="2" type="ORF">ERS852471_00473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263525.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75705">
        <property type="protein sequence ID" value="CUN75705"/>
        <property type="gene ID" value="ERS852471_00473"/>
    </dbReference>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047739">
        <property type="term" value="F:cephalosporin-C deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="321" mass="36538" checksum="A8662DE10605628B" modified="2016-09-07" version="1">MPIVDMPLERLREYKGTNTLPSDFSEFWNERINEVKNHPLKYKITESEIRGFEGCEFLDLWFKGIDGGKVYAKYIRPKTDEDVPLILQFHGYPGASRGWFEQLSFVGMGCAIIAMDCPGQGGNGDSYTNMKGTTVSGHIVAGLDGDICNMYYVKLFQNASILCRIVKELNGIDKERIYANGASQGAGIALVCAALNPIIKKCAALYPFLSDYKRVWDMDLDMIAYEGLRYYSRWFNPMNDKEDEMFTKLGYIDVHNFADMINCEVLFGTGLMDNVCPPSTQFAIYNNIGSKKKHIIFPDYTHEEIGEFDDMLIDFFLKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZL69</accession>
    <name>A0A173ZL69_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263549.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76370">
        <property type="protein sequence ID" value="CUN76370"/>
        <property type="gene ID" value="ERS852471_00487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="65" mass="6864" checksum="7DAD4B0B2C490413" modified="2016-09-07" version="1">MGKGKNKGRVSSKSKGKNEKSSAISFLALCMIIGLLLGTIYNQVIIGVCLGTLVGVIIDARNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZW65</accession>
    <name>A0A173ZW65_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase DbpA</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">dbpA</name>
        <name evidence="12" type="ORF">ERS852471_00503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DbpA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263599.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79646">
        <property type="protein sequence ID" value="CUN79646"/>
        <property type="gene ID" value="ERS852471_00503"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00965">
        <property type="entry name" value="DEAD_helicase_DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028619">
        <property type="entry name" value="DEAD_helicase_DbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="230"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in 23S rRNA binding" evidence="6">
        <location>
            <begin position="404"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN79646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="479" mass="54004" checksum="3F74CBD68D2EF043" modified="2016-09-07" version="1">MNKFNDYKISNEILKALDALGYNKPSDVQQRVIPEILQGKDVIVKSQTGSGKTAAFGIPLCEKLNWDEQKPQALVLTPTRELAIQVKEEIMSIGRFKRIRPVAVFGKQPFSDQARELKQRTHIVVGTPGRVMDHIDRGSLNTSNIKYLIIDEADEMLNMGFIDQVREILRGLNKNRQSILLSATISEEILNLCNEYMNNPISIEIKAQKLITDNINHELYRVNEQYKMEELNKLLISEAPKTAVIFCKTKENVDKVFEALGRKRYSIGKIHGGMLQKERMDQMDRFKKGNFRILIATDVAARGIDVEGITHVINYDLPVEKEAYVHRIGRTGRAGAKGKALSLVNQYEDRLLNLIQEYIGFEIPLKDLPSEDEVKAKEMEGVKILKSNPTVKKQKAKAVSKDITKIYLNGGKKKKIRPGDIVGAISRIEGITAEDIGIIDVQDTVSYVDILNGKGNKVIDGLRNGTIKGKKLKIERARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZF2</accession>
    <name>A0A173ZZF2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263619.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80645">
        <property type="protein sequence ID" value="CUN80645"/>
        <property type="gene ID" value="ERS852471_00514"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN80645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="31972" checksum="8915BCC39DA8CD7B" modified="2016-09-07" version="1">MELFVTDLDGTLLNSKKEVSKYSCDTLNKLIDDGVNFTVATARTPATVVELLEGINLKLPVALMNGVLIYDIKEQKYIDIKEIEKDTVKKCLEIFEELDKNVLVYGIKDNHLWVYYKEFQYAWEYNFYKERADKKLKTFVEVTDYKEAIKDSKVINFIVFDKYENIKRINDELTKIQGLTVNYYEDIYEEDCYFLEAYSSEASKANGIKFLERYIEHDNLVCFGDNLNDIPMFELADEAYATANAVDELKEMATAVIGSCDEDGVARFLEERFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASR7</accession>
    <name>A0A174ASR7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntcA</name>
        <name evidence="4" type="ORF">ERS852471_00655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263872.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90516">
        <property type="protein sequence ID" value="CUN90516"/>
        <property type="gene ID" value="ERS852471_00655"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN90516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25275" checksum="F41CDDFB848116A1" modified="2016-09-07" version="1">MKNKLSNNFLFKGVSDEEIESIFSYIKYSETSYNKGQILFQEGDICENIGIIEEGLIQLERIYSSGKSIVLAKLSEGDVFGEALVISSKSLYPATVIAKSDCKIIFINRKEILKLCSKSEKILENFITLLSDKVIMLNKKVKSTSLKSINHKVVDYILEKSSIANSNIIMLNESKEDIAAYLGIPRPSLSRELINLRDEAIIDFDRKSITILNYNKLEEKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AYU2</accession>
    <name>A0A174AYU2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na/Pi-cotransporter family protein/PhoU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_00683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN93981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263946.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93981">
        <property type="protein sequence ID" value="CUN93981"/>
        <property type="gene ID" value="ERS852471_00683"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1341748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="9">
        <location>
            <begin position="343"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="9">
        <location>
            <begin position="449"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="430"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN93981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="541" mass="58886" checksum="6EA09DFDD2250C24" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9R9</accession>
    <name>A0A174B9R9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264053.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97742">
        <property type="protein sequence ID" value="CUN97742"/>
        <property type="gene ID" value="ERS852471_00746"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2171044at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="24758" checksum="428B10D7728E411B" modified="2016-09-07" version="1">MDSNKTNKTNKNKKDNDLTFAPMNIQDALKPANFPTPNISGGPMSNGTMYMCFPAPSINMMNPAMNNENKPSTVPLTPYPSNIPDIEQTQTLPSTNTNNSNNTTNKVPSSFPTESSNLEYPSEVNSEDLYSYNKPRLNDNYDKNSVNPLDIVRNFTLEDISLSNDYRGDNKESEVDKIFKKIEDNNSVVLATMKAYRIPYPIAKLLIKNIIKLTLEYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2S7</accession>
    <name>A0A174C2S7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neutral protease A, bacillolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264338.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06589">
        <property type="protein sequence ID" value="CUO06589"/>
        <property type="gene ID" value="ERS852471_00887"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30772at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1303"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="7">
        <location>
            <begin position="1132"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO06589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148649" checksum="3FABCB5B25FDE6A4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4W2</accession>
    <name>A0A174C4W2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="3 8">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">scrB</name>
        <name evidence="12" type="ORF">ERS852471_00890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="3 8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06746">
        <property type="protein sequence ID" value="CUO06746"/>
        <property type="gene ID" value="ERS852471_00890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="10">
        <location>
            <begin position="31"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="11">
        <location>
            <begin position="344"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO06746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="475" mass="55609" checksum="08182EAF79F341A3" modified="2016-09-07" version="1">MLKEKFLNEIKECKEKYLDIVKNDKWRNKYHIMAPIGWINDPNGLCEFNGEYHCFYQYSPLTPMGGQKFWGHYASKDLVNWEEKEVAIFPDIYEDKDGVYSGSAFVKDGTVYFFYTGNSKEPGEHDYIYTGRGHNVILVTSKDCVNFSEKTIVLRNEDYPSNMSCHVRDPKVWEEDGIYYMVLGARTRDDKGCILLYKSKDLYNWELHSIPAGEEEKMGYMWECPDIFKLNNKEVFMFSPQGVEAEGYKYNNVYQTGYTIGHFTDNKKVLEHGKFDEIDRGFDFYAPQSFEDSKGRRLFIGWMGVPDAVEHKNPTIDNFWQHQLSIPRELVLKDEKIYQIPVKELETLRKDKLEIKNVVLKDRIDKDIFESNTFELNIEFNDSNDFIVELREDCRLSFKDKVFKLELGKSGYGRDMRAVEIESVKSLRVFSDESSLEIFLNGGEEVFSTRIYNDGMDKTIKIEGNGTADIIRYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6G7</accession>
    <name>A0A174C6G7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">agaR1</name>
        <name evidence="10" type="ORF">ERS852471_00934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264431.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09111">
        <property type="protein sequence ID" value="CUO09111"/>
        <property type="gene ID" value="ERS852471_00934"/>
    </dbReference>
    <dbReference type="OrthoDB" id="131906at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="9">
        <location>
            <begin position="31"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="8">
        <location>
            <begin position="650"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="476"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO09111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="729" mass="83488" checksum="50C6D94FAEFD07F7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8G9</accession>
    <name>A0A174C8G9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha,alpha-phosphotrehalase</fullName>
            <ecNumber evidence="2">3.2.1.93</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">treC</name>
        <name evidence="2" type="ORF">ERS852471_00948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.93" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264459.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09821">
        <property type="protein sequence ID" value="CUO09821"/>
        <property type="gene ID" value="ERS852471_00948"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008788">
        <property type="term" value="F:alpha,alpha-phosphotrehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012769">
        <property type="entry name" value="Trehalose_TreC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02403">
        <property type="entry name" value="trehalose_treC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO09821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="554" mass="65159" checksum="CE086C64C2298908" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9V4</accession>
    <name>A0A174C9V4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264415.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08665">
        <property type="protein sequence ID" value="CUO08665"/>
        <property type="gene ID" value="ERS852471_00926"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2173330at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7593" checksum="5D93276D38F9A2C9" modified="2016-09-07" version="1">MKESKNALELALHLFKIGELIRDMDEKINNEDDNELKRIYINEREDMYSTQIDMIHKLRSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAN5</accession>
    <name>A0A174CAN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system, ATP-binding protein OppF</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppF_2</name>
        <name evidence="6" type="ORF">ERS852471_00929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264421.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08798">
        <property type="protein sequence ID" value="CUO08798"/>
        <property type="gene ID" value="ERS852471_00929"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO08798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="38230" checksum="7925761705FF7BBC" modified="2016-09-07" version="1">MSLLKIDNISIEFDNRVNKKEKVKVLSDINLEVGEGEIVAVVGESGCGKTTLGKLIVGIHKQTKGKILYKGKDISKLKRAEFKDYRLGVQMVHQDSFAALNPNRTIFQSLSMPLLQHKIAKNKAEAEKILKEYFAEVGLVPQEQFLYKYPHQLSGGQRQRILLARALSVKPKLIVADEPVSMVDVSLRISLIDLMTKMNKKYNISFVYITHDLATARYIAKNGRLVVMYLGKIIELNNIYDAIDHPKHPYFHALLAAVPQSVGKRSDGGSKELPLRTLDMPSIINPPSGCKFHTRCPYYTEKCEKEEPELLQYKGGYVACHHVERIEREREKVKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDY1</accession>
    <name>A0A174CDY1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">treR</name>
        <name evidence="2" type="ORF">ERS852471_00947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09776">
        <property type="protein sequence ID" value="CUO09776"/>
        <property type="gene ID" value="ERS852471_00947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012770">
        <property type="entry name" value="TreR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02404">
        <property type="entry name" value="trehalos_R_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO09776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="26669" checksum="47759E9BAC672AB1" modified="2016-09-07" version="1">MNIYNILVDKIENNEYQANDKLPSEKEIMNDYNVSRDTVRKALNMLEQNGYIQKTKGKGSFVLDIGKFNFPVSGVVSFKEISGKLGMKVETIVESLECIVPKKNIARGLELSGDDKVWRVVRARSVDDEKIILDKDYIVQKFVENLTYDICKESLYDYIEGELGLKIAYAKKEITVQNATEEDKKYLDMKGFEMIVVVKSYTYLDDTSLFQYTESRHRPDKFVFVDFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVR1</accession>
    <name>A0A174CVR1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264600.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17293">
        <property type="protein sequence ID" value="CUO17293"/>
        <property type="gene ID" value="ERS852471_01068"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="19079" checksum="23FCF489322987B5" modified="2016-09-07" version="1">MILRKSDINDINSIMNIIKQAQEYFKLEGIDQWQNNYPNADTIHNDIENGESYVLVKDNNIIATTALSFNGEPTYNSIYEGSWINNGKYATIHRIAVDNNYKGLGVAREIIKQVEELSAKEDVHSIKADTHEDNLSMQKMLKKNGFQYCGVIYLEDGSKRVAFEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CW10</accession>
    <name>A0A174CW10_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M24</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264604.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17671">
        <property type="protein sequence ID" value="CUO17671"/>
        <property type="gene ID" value="ERS852471_01078"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="313"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="528"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO17671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="587" mass="66325" checksum="02E19C91AD35F8C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CW66</accession>
    <name>A0A174CW66_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">mprF</name>
        <name evidence="7" type="ORF">ERS852471_01077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264603.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17612">
        <property type="protein sequence ID" value="CUO17612"/>
        <property type="gene ID" value="ERS852471_01077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO17612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="41970" checksum="706BC6C458DA704C" modified="2016-09-07" version="1">MKIKSSYKKIFQILLISIILFIALKEFYSMLTTIDMNLFYIYADELTLSKLLIVLVLGLISYLPLSFYDLLLRKRVNINLKLTQLYKYSWIASSIANVVGLGGSTALILKSHFYSKYTDDKKKLTKILSKIVLFNLSGFAMVCFVFSISNILKGNFSGFTNIAAFIISLYIPVVLTILIRKYLKTKDSGEFLFSINICLISVSEWITTIILIYGLMFILNISINPLDFLSVYVSAIIVAVISMTPGGIGTFDLALLLGLGNYGVPSEQVLLLILLYRISYYLIPMLIGMILYSFELCRDLSSKVRTLLKDMLAVSSHFILLLILLLIPIWILMPIIKVSIIPTKIIYLFNKVVQKLLNLGLKLPIISLSKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4P4</accession>
    <name>A0A174D4P4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydhF</name>
        <name evidence="2" type="ORF">ERS852471_01136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264655.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20601">
        <property type="protein sequence ID" value="CUO20601"/>
        <property type="gene ID" value="ERS852471_01136"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="34804" checksum="10F74C4C252D8D77" modified="2016-09-07" version="1">MKNIILGTTDIKASSIGLGCMRIADMEKEDVNKLINIALEEGINFFDHADIYGKGRSEEIFSEAIGMNSSLREKMIIQSKCSIRPGFYDYSKEHIISSVDGILKRLKTDYLDILLLHRPDTLMEPEEVSEAFEELFKAGKVREFGVSNHNPMQIELLNKYLKNKIMINQLQFSLMHTGIIDSGINVNMKVEPSIDRDGSILEYCRLKDITIQAWSPFQYGFFEGVFLNNDKFPELNAKINEIAEKKNVTNSAIATAWILRHPAKIQTIVGTTNTERLRDICKASEVELTRQEWYELYRAAGNQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5A3</accession>
    <name>A0A174D5A3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phoR_7</name>
        <name evidence="7" type="ORF">ERS852471_01132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264651.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20417">
        <property type="protein sequence ID" value="CUO20417"/>
        <property type="gene ID" value="ERS852471_01132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="843"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO20417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1071" mass="122096" checksum="764E53EAC2554D2F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8F5</accession>
    <name>A0A174D8F5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264649.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20325">
        <property type="protein sequence ID" value="CUO20325"/>
        <property type="gene ID" value="ERS852471_01130"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO20325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="189" mass="20802" checksum="47C04941B138B442" modified="2016-09-07" version="1">MKKTWTIVIAIVVVLAILIVPIVTTYNDLVSLEQNVNIAESNIDTQLQRRSDLIPNLVNTVKGYASQEKDIFSDIANARSKLAGATNVTEQANADNELSSALSRLLVVVENYPDLKSNQNFQDLSIQLEGTENRIAIARQDYNTAATTYNTKRKSFPANIVASIFGFQEKSLYKASEGAQEVPSVDFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM59</accession>
    <name>A0A174DM59_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein involved in cellulose biosynthesis (CelD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264727.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25185">
        <property type="protein sequence ID" value="CUO25185"/>
        <property type="gene ID" value="ERS852471_01208"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="179"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="353" mass="42718" checksum="0A1ACA8ABF6573F2" modified="2016-09-07" version="1">MKGKIEFKIINEINDFENLKEAWIELFNNLENKEIFYEWIWIEEYIKYFKNNNFKPFVVVGEEKGKIVTIAPLYIEEKKFGIIKKRILKFIVDRTADYQCILIRKDYNHYSVLKKLFKIIFEDESWDMISLNNISYREKQSILIGEVIGRLNDEAICYKKVEKIAPYINLEEFEEKRNSKRYKNIERKERAIDKNERININIDSKWDKDIWYQLVNIHKNTWKDSILKNENYVHFYESLFYKLYECGKLEFSYVTYDNQVISGHLGFKCCNKVYGYNLYNDESWKKLSMGDILIKKIINHYKNSYDLIDMLLGDEEYKFYSTDSVINICDYTIIRKKQILLRLGKKIKSCLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQL0</accession>
    <name>A0A174DQL0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobQ_1</name>
        <name evidence="1" type="synonym">gatD</name>
        <name evidence="3" type="ORF">ERS852471_01259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264803.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27773">
        <property type="protein sequence ID" value="CUO27773"/>
        <property type="gene ID" value="ERS852471_01259"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO27773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="241" mass="26999" checksum="5BDE08DEC3C47495" modified="2016-09-07" version="1">MELNICHLYPDLLNVYGDVGNILILKHRAEARGIKVNIINVSMNDTFNSEDYDIVFFGGGQDFEQSIVSDDLMNNKKEELSKYINSGKVLIAICGGYQLLGKYYTAPNGEKIEGLGILDIYTEAGDKRFIGDTVIYNEEFDETYVGFENHSGRTYVNGLKPLGKCIHGYGNNGSDGYEGCVYKNTYCTYFHGSLLAKNPELADRFIKTALDVKYSEIALEKLDDSLELKAKEKMITRLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXV1</accession>
    <name>A0A174DXV1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264905.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30371">
        <property type="protein sequence ID" value="CUO30371"/>
        <property type="gene ID" value="ERS852471_01316"/>
    </dbReference>
    <dbReference type="OrthoDB" id="591394at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="366" mass="42645" checksum="642CC2DCF8119CF3" modified="2016-09-07" version="1">MNKRVFLAKEDQYYNKLGIGKKVDIWEDGLRTSGDRGSYEWWYFDAEYNNGCRFVVIFYTKDRFDVKGPGKPTATLDVTLPNGQTICRTITEENKNIIDASRERCDVKIGDSFIKYQDGNYYIHFEDTLVQYDCVMKSTLPMYRPKTGYTFFGENENLYFGWFVPQPSAEASGQVKVNGLSMKLEGNGYHDHNWGNVQMDRIINHWYWCRAKIGPYTIVANDIISEKKYDYLRSATLFIAKNEEVLVEDENKIKIERNNTKEHNLTEKFIDNNITFIYVDENETKYTIEFIREKDIFASSLLNVMGLSYSEILFSVSRGINPTYLRCIGKARLTIESSKGKEVLESDALWEQMFFGNNKIAYIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZ62</accession>
    <name>A0A174DZ62_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29499">
        <property type="protein sequence ID" value="CUO29499"/>
        <property type="gene ID" value="ERS852471_01296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO29499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="58" mass="6909" checksum="DD9BC4A13AA43738" modified="2016-09-07" version="1">MNCYDLTLEYVRILDDLQRTIDKKSKAPAIDQGWLETDINKLEIRLFEIIDILKKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E277</accession>
    <name>A0A174E277_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">asd_1</name>
        <name evidence="12" type="synonym">asd</name>
        <name evidence="14" type="ORF">ERS852471_01322</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264913.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30596">
        <property type="protein sequence ID" value="CUO30596"/>
        <property type="gene ID" value="ERS852471_01322"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="36852" checksum="D814E44C56E5C652" modified="2016-09-07" version="1">MKKANLAIVGATGMVGRTFLKVLEEKKFPINNIYLFASKKSAGKSVKFLGRDIIVEELNHDSFKRDIDIALFSAGGEISKEYAPIARENGVVVVDNSSAWRMDKDIPLVVPEVNPEDIKWNNGIIANPNCSTIQAVVPLKVLHDAYKIKRIVYSTYQAVSGSGVGGIDDLDNTIKGLENKKYPYKIAYNCLPHIDSFMDNGYTKEEIKMIEETKKILNDDTLRITATTVRVPVKYGHSISINVEFEKDFDVEDVFKLLENSEGIILQDDVKNNIYPMAINCEGKDEVFVGRVRRDFSVESGLNLWVVADNIRKGAATNAVQIAEILVKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E526</accession>
    <name>A0A174E526_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264959.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31556">
        <property type="protein sequence ID" value="CUO31556"/>
        <property type="gene ID" value="ERS852471_01347"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2005506at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="15295" checksum="05E2C1DE1AEBA4FC" modified="2016-09-07" version="1">MYNILALVIGALISIMLSFNGSLEGNVGLTYSLIIIHTVGLFTIAIIMLIKRAKITVREKLPIYMFFGGAIGVALTLVNMITISKIGVALTTSLAVFAQLIFSSFIDHFGLFGMNKYRFNKKKLIGFAIVLVGLVIMTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E864</accession>
    <name>A0A174E864_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">ERS852471_01373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265011.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33853">
        <property type="protein sequence ID" value="CUO33853"/>
        <property type="gene ID" value="ERS852471_01373"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="501" mass="56149" checksum="4A564C40D25096F3" modified="2016-09-07" version="1">MKKRALISVFNKDGVLDLARFLESIDVEIISTGGTFKYLKDNGINVVEVNEVTNFPEMLDGRVKTLHPIIHAGILAIRDKEEHMNTLKEREINTIDYVVVNLYPFFEKVREDLSFEEKVEFIDIGGPTMLRSAAKNFRDVVVLSDKEDYERVIDEIKKNGEVSFKLRKILAGKVFNLTNAYDAAISNFLLEGEEEYPEYLSISYKKKQSLRYGENPHQSAAYYSSNEFDGAMNSFEILNGKELSYNNIKDLDIAWKVCNEFEETACCALKHNTPCGVAIGESSFEVYKKAHDADPISIFGGIVAVNREIDEETAREMSKIFLEVVAAPSFTEGALEVLKAKKNLRVIKCNQKPSAKKFMVTVDGGILVQEEDLKLQNELKVVTEKKPTENELRDMEFGMKVVKYVKSNAIVAIKDGVAIGIGGGQVNRIWATTEALERGKGATVLASDAFFPFRDCVDEAVKYGIKAIVQPGGSIRDEESITACNEHGISMVFTGIRHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIG1</accession>
    <name>A0A174EIG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative virion core protein (Lumpy skin disease virus)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265113.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36488">
        <property type="protein sequence ID" value="CUO36488"/>
        <property type="gene ID" value="ERS852471_01434"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826236at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO36488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="29646" checksum="9550625F33F63A1B" modified="2016-09-07" version="1">MLIMFMPMIFMAIIFGLFIWQAIWVALDSRKRGEEYWWLWTIAAFIAFPVGIIVYAIVSRSDRRRCNNCGKEVPKDLKLCPYCGERCGNFCPNCGQNVQPGWRFCPNCTTELPDEITNSKRKINNKPIIIVVSIIVVLAILFVGMFVVSYVSFSGITGSYTEEINTFDTSGYQGRVFNERTTDVLEYTITSNQHSFWCKGEREKGDIVVKVYDKDGNLKSETDKISAEEFTEGMFVEPGQKVEVYLNDYKGSFYVRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPF4</accession>
    <name>A0A174EPF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase, HXTX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265214.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39157">
        <property type="protein sequence ID" value="CUO39157"/>
        <property type="gene ID" value="ERS852471_01491"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="177" mass="21185" checksum="5DF44085EE82992A" modified="2016-09-07" version="1">MSETYVIVAIIKGEAGEFNNNLRKDVFNDLGLKSSKLPAHFTIKAPFKHEGSIELLEKTLENFCSHEKKSPLIIDEYDHFDDRVVYMKLNMSKEGKEVHDRLIDELERIPYINFDKKDGKNKVFHVTVSSKNVRRKFTELWDYVQLRPCYFESYFDNICIYKWSNHTWELYKEYKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ERS7</accession>
    <name>A0A174ERS7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265220.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39316">
        <property type="protein sequence ID" value="CUO39316"/>
        <property type="gene ID" value="ERS852471_01494"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="31165" checksum="FCEA8C0D2EBDFD07" modified="2016-09-07" version="1">MGDLIYRLLLFLNDSREETLNYTIALTMIRNIRDIPNMTINKLADMCYTSPAAISRFCRKLGYSSLSEFKKALSISINTNFDNSFSKPRGFKTKRNREEILELMHDEICNELTLTKNSLDLKLIDRVIDLIYRSDHICIFGTLFSQLMCQQLQTNFARVGKLINIATDIQAQEKLASSLTPNSLAILISPTGRFIAYHERVWNNLLATDCKIVTITENRENKYKEGSDYIIYLAQSEYNNQYLPENQHALMMLVEYLFIRYADLYSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUP4</accession>
    <name>A0A174EUP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265264.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41474">
        <property type="protein sequence ID" value="CUO41474"/>
        <property type="gene ID" value="ERS852471_01516"/>
    </dbReference>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO41474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="361" mass="41642" checksum="C871C790E4CF7DF2" modified="2016-09-07" version="1">MNFTEAMNTIELVTMTNDVPLIIGESGIGKTSMVRQIAKNNNLAIVNIDANLLKEGEIGGLPFVNNGRTEYATHYKLTEVSSLLNDNKYDGVVLFIDELNRCEHAVQQELMNLILNREINGYKLDSSVKIIAAMNPSNKYDNFENSDYQVIDMDAAQEDRFVWVEVDSDSKEWIKWAMTDEADIEEEVIEFISQFPNYLHMPYANENIKPTPRSWERVSKAFKMYKNNKDKYSEAIIFNAVKGNVGGGIATDFIGFARNFNSPLIKAENLLDYDFIPYEIKEMIQKENHSRLYMLAKRLVQLLNEEENRDKIKILGEVLMCYPKDLRLGVMKDIKEDYNGGLYKEILSQDTFIEAFFDIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYB2</accession>
    <name>A0A174EYB2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wbbL_1</name>
        <name evidence="2" type="ORF">ERS852471_01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265298.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42297">
        <property type="protein sequence ID" value="CUO42297"/>
        <property type="gene ID" value="ERS852471_01534"/>
    </dbReference>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="33807" checksum="BA1F73272EC78C46" modified="2016-09-07" version="1">MGLGLVVLNYNDYETTINFINNIKSYKNIDKIVIVDNNSSNESVEKIKSVIDNRIELIESQENAGYGSGNNIGIKYLEKFDEIKYIGISNPDINFKESDIDDLLGLFERNDRISLLSGRIVENNRFASDGAWRLPTYKECLLQCIPLIDKIINKNLSYDESHYNGEYSIVDIIKGCFFIVKKDVFKDISGFDEKTFLYYEENIIGKKMKEKGYLIATLNCIDIYHMHGETINKSIDKLNRFHILGESRRVYVRDYLNVNKYGIVLYNNFNSIGLFIRKLIYILSDLVNKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F311</accession>
    <name>A0A174F311_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnQ_2</name>
        <name evidence="9" type="ORF">ERS852471_01579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265388.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44613">
        <property type="protein sequence ID" value="CUO44613"/>
        <property type="gene ID" value="ERS852471_01579"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1533843at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO44613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="425" mass="44633" checksum="F71FCA261C7F33EA" modified="2016-09-07" version="1">MKKSTKDSIVIGFALFSMFFGAGNLIFPGFLGNGLGSDFLLGTVGFVVTGVGLPLLAIVACSKGDGTLESIGNRIDRKFILIFTTVLFLAIGPLMAVPRTAATTFELSVNPFLPSVPAIVAITVYFAINLFFVLKQSSIVDTIGKFLTPALLILLIVLIVKGIISPIGEIIDTNATSVLSSSLIEGYQTMDALGALLFASIVTTSLKDKGYKGKEMPKMILKSSLVATIGLAFIYGGLIYIGAQTSGLVSQEIGTTGLLLLISESVLGKVGPAIIGLAMGLACLSTSIGLVSVGASFFEKISKGKLSYTLNAIVITIISLAVATLGVDKIVALSGPVLNLLYPVSITIIVTALMSKYLTNMKAVRLGIYTSLIFSLLLLIPGLNLSFLPLADLGFGWVIPTILSIVIGLFIFKEKECESTLKNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4S4</accession>
    <name>A0A174F4S4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2922)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265420.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45352">
        <property type="protein sequence ID" value="CUO45352"/>
        <property type="gene ID" value="ERS852471_01596"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034992at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021321">
        <property type="entry name" value="DUF2922"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11148">
        <property type="entry name" value="DUF2922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="71" mass="8017" checksum="4CFC25B33AB6BA46" modified="2016-09-07" version="1">MEYTLSMTFLTETDEKYSLSISGVRTNLNSEEVSALMDIILENDIFISKKGSIVSKYAAKITERQVTSFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6R3</accession>
    <name>A0A174F6R3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">galU_2</name>
        <name evidence="5" type="ORF">ERS852471_01610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45953">
        <property type="protein sequence ID" value="CUO45953"/>
        <property type="gene ID" value="ERS852471_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO45953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="24290" checksum="73B079EBA79DC42F" modified="2016-09-07" version="1">MEKKIRKAIIPAAGLVTRFLPATKAQPKEMLPIVDKPTLQYIIEECVASGIEEILIITGRNKKSIEDHFDRSVELEMELEKSGKQEMLEMVREISDMVNIHFIRQKEPRGLGHAIHCAKAFVGDEPFAVLLGDDVVYNDQKPCLKQLIDCYSEYKTSVLGVQTVDPKDVNKYGIVGGLHIEDRVYKVKDLVEKPAVEEAPSNVAILGRYISETLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FBX8</accession>
    <name>A0A174FBX8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47772">
        <property type="protein sequence ID" value="CUO47772"/>
        <property type="gene ID" value="ERS852471_01628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="136" mass="15171" checksum="8ADA18CFD62221EA" modified="2016-09-07" version="1">MKRQENRAVLAWRGAASAGLDSSADRAYMKAPVPRPTLQLVDKVSRSCGHTPGKVAGQRATVKAEMNGFTPGLDLRPLSRWMGGQGGQSLKVLGRSLSDFEVFSFSKLNNQNKFFRLKKFYLLSSSMPYFFFCRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCA5</accession>
    <name>A0A174FCA5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">algA_2</name>
        <name evidence="2" type="ORF">ERS852471_01621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265467.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46558">
        <property type="protein sequence ID" value="CUO46558"/>
        <property type="gene ID" value="ERS852471_01621"/>
    </dbReference>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="39434" checksum="705A898916D45D39" modified="2016-09-07" version="1">MLTALIMAGGKGTRFWPLSTEERPKQFLNLIGEETMIQMTVNRIKPIIPIERIFVCTGEQYVSLIKEQLPELPETNIIVEPEGRNTAPCIALSAFVIRRYYEDATMVVLPSDHLIKNEEEFRNIVKIADEFVRSNDSGIITLGMKPSRPEIGYGYIKYGNGVQGLNNNEVIKVDAFVEKPNKQKAEEYLADGSYLWNGGMFLWSANNILEKIKKYSTDTYEALHQIDEVKEEELQELINNNYKNTEAISIDYAVLEKSKDIYVIPSDFGWDDVGSWEALDRYREKDTYGNVLVGQSKAIKAENNLVISSNHKVVVEGLSDIYVIEHDGKILVGNKSNVANVKELKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCT7</accession>
    <name>A0A174FCT7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase CsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265453.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46160">
        <property type="protein sequence ID" value="CUO46160"/>
        <property type="gene ID" value="ERS852471_01614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="13"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="366" mass="43096" checksum="96C7BD0C6277A1D1" modified="2016-09-07" version="1">MKILITGYYGAGNFGDDIMLEAFCKRMKSENPEIEISILKMFDRELNIDLDSSIKVINYYKLKRKLNTAIFMMLMMKYDMFVWVGGTCFTDEDGNGLYWLMKRAKQLRKKFGYIGVGIGNLTKKERIDMTEYLLNNCEFISLRDKRSYDYVKKVRMNTKNVYLTEDLAYLFVDKHERKENKEICKKIVVSWRNLVNYRTEEEEQVLMNNLINYLKKLSEETVKIEILILPLDDRKDCEKNQIIYQKLLGSENKYTTIKYLENISPVEKIEKILECDLNICGRLHGIFVSELNNINTVALSYSIKIDEFLKSINKECDCISIDNLTVESLENIEKNNSRMISNNIIKEKIVSSNNNIKYFIDYLNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FII1</accession>
    <name>A0A174FII1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional antiterminator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">licT_2</name>
        <name evidence="2" type="ORF">ERS852471_01671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265560.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49983">
        <property type="protein sequence ID" value="CUO49983"/>
        <property type="gene ID" value="ERS852471_01671"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1193348at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001550">
        <property type="entry name" value="Transcrpt_antitermin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00654">
        <property type="entry name" value="PRD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="172"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="33062" checksum="B62800957DFB23B1" modified="2016-09-07" version="1">MIIEKVLNNNVVVSIDPKTKKEIILLGSGIAFNKKIGQEVDESKIEKTFVLDDKTLGNKFKKLINQIPDGVFQLSHEIISHASKELNAKFDKQIYISLSDHIAFAIKRYKKNMMIKNELLNEIRRVHKKEYKVALWALEFLNRKLKIELPEDEAGFIALHFINASLNQSTINSIESTKIVKDILNIIRYYFSLEFKEDDLNYDRLLTHLKYFSKRIIENNQDNASEDEFINMVIKSYPEAYNCTLKIKEYIVNNYKYDVNSNEIVYLTLHIQRIVSVSRYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIS6</accession>
    <name>A0A174FIS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265517.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48726">
        <property type="protein sequence ID" value="CUO48726"/>
        <property type="gene ID" value="ERS852471_01647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO48726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="16508" checksum="E4E3BC70AEE30965" modified="2016-09-07" version="1">MSNYSFQYKEYYEGLKKKHNISNSKSKISYDEDIPIYRGSTVYSKNRRNKNESFISNLLMMQLVGTMMLFLFAFGGKYSTNDDIRQYYTKFKYGIEQEYTYANANVNSKEIKIESIKNKFLESIDWIKEKLINDDFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLI7</accession>
    <name>A0A174FLI7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49686">
        <property type="protein sequence ID" value="CUO49686"/>
        <property type="gene ID" value="ERS852471_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO49686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="49" mass="5945" checksum="78F2923C4112B66A" modified="2016-09-07" version="1">MKKILLIIIVAILLFITIINFQDDNNFKDKSNLFRVEKIKWIPLYFFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPP6</accession>
    <name>A0A174FPP6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Peptide chain release factor 2</fullName>
            <shortName evidence="6">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">prfB</name>
        <name evidence="9" type="ORF">ERS852471_01690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50826">
        <property type="protein sequence ID" value="CUO50826"/>
        <property type="gene ID" value="ERS852471_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="8">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO50826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="325" mass="37154" checksum="9EE2B107BAEB5D09" modified="2016-09-07" version="1">MQEKGFWDDIKRAEEVTKESKSIKDKIDRFESLVNRIDDVEVLAEIVEDDEETVNEIIYEIRDIEKLIEEYRIELLLSGEYDKNDAILNLHAGVGGSDANDWTDMLLRMYTRWCEKKGYKVQVVDLLEGDEAGIKSVTLKVKGEFAYGYLKAEKGIHRLVRISPFNANGKRQTSFASVEVLPELTKDQDIDIRPEDLKIDTYRASGAGGQHVNKTESAIRITHIPTGIVVQCQNERSQFANKDTAMAMLKSKLIELKDRAHKEKIEDLTGELKDMGWGSQIRSYVFHPYNMVKDHRTNEETSNLSAVMDGGIDQFITAYLKQNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV06</accession>
    <name>A0A174FV06_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265657.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52636">
        <property type="protein sequence ID" value="CUO52636"/>
        <property type="gene ID" value="ERS852471_01729"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2167875at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="42306" checksum="D88CECF217863B04" modified="2016-09-07" version="1">MKKYKIIITLIIVIICLYIIYNTDFANSKNDIEVKNTLNKSILESELSFNKILGELEQDIPWLPLGVSDDGIIYGYTGRNENSKYNLLAYNMDTSTSNIIHEVENDLRPVLLKENNKYIVWIEGVYQYEKQGTRIKLCDKSTNEIVTIFESDSFLSLDSSPLSLGNDFILWVDYEYKDNMMYPLIRKYTISTGETSVFKENATSPVILNNCIAYITEDIYNHNSSAVCIENIETNEVRQITNNKKVLYIEGDNESLVVSSVDYDKKYYLDVYTKNKLITIQANNDYSYDFPKISERFISWQELDKIQFYDRKNEQVINIGDHSNITTCNISDNYIIYTTPELSLETQKEYAAIHGMVLSNIHIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FVD3</accession>
    <name>A0A174FVD3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal transduction histidine-protein kinase ArlS</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">phoR_9</name>
        <name evidence="14" type="ORF">ERS852471_01762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265731.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54262">
        <property type="protein sequence ID" value="CUO54262"/>
        <property type="gene ID" value="ERS852471_01762"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041610">
        <property type="entry name" value="ArlS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18719">
        <property type="entry name" value="ArlS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="248"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO54262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="52897" checksum="BB2BED111EA257BD" modified="2016-09-07" version="1">MNSVRSKLIKNFLIVIVSTVIILDIFMIVFFKEYYYKNRQDFLTNQIESSINFYDKYFSSQTLIQNIYDNIDSFWNNINAQVEILDPNGKLLMDSIGIRDDKLLQTPDIGKAINGETARWVGKSDYYHGNIMIVSHPIIINGELNGIIRVISSLEDIDNTINAFIILFLIISSIVILIGLILSILMAKSIVDPIKSITKVAKKMASGDLKIKSPVYNNEEITQLSNTLNYMASEIEKREKLKNEFISSVSHELRTPLTAIKGWVITLNDDETDKETLKMGFDIIEKETDRLTLMVEELLDFSKLVSGIVHLNKRNVDIRSFVTHIENYMKPRAVNEDIVFNVDISNNVSKGFFDYNKMKQVLINILDNAFKFTDKERKVSLFVDQNESDIKFTIIDSGVGISEEELPKVKEKFYKGKNSNSQNGIGLSICDEIIKLHKGTFNIESELGKGTSVKITIPNIKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2S4</accession>
    <name>A0A174G2S4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265736.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55416">
        <property type="protein sequence ID" value="CUO55416"/>
        <property type="gene ID" value="ERS852471_01767"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO55416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="121" mass="14192" checksum="D4C0CE0AC8E22B02" modified="2016-09-07" version="1">MLSILFGLKVSECCKMKGKDIKLANDYIHVHDSKGKRCRDIKIETEQQRKFCEYIKAIVSDEARICPLREDSVNQEVRRILLKHQINRYKDSKTGIHSIRKSYATEKYKDNLQQGMDETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G452</accession>
    <name>A0A174G452_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55640">
        <property type="protein sequence ID" value="CUO55640"/>
        <property type="gene ID" value="ERS852471_01772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO55640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="175" mass="17774" checksum="6E3A03F1141FCD41" modified="2016-09-07" version="1">MGKVKYTNKESLNPIKNIISKAGEMTSSESVISKNDKGLSEVLAAAAGMSVGAAGSFAALGTLGIAGYSAVGITTGLATAGGIVGGGMVAGIGVLAAPIAVLGVGGYALVANKKKKELLLEKKALLQEAIRKQNIVIDKLKNKVELVEEKARELEAMNIILTGIINDLKGDIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIR7</accession>
    <name>A0A174GIR7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium uptake system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trkA</name>
        <name evidence="3" type="ORF">ERS852471_01885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265954.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60850">
        <property type="protein sequence ID" value="CUO60850"/>
        <property type="gene ID" value="ERS852471_01885"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO60850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="24412" checksum="197BB509C6138C9D" modified="2016-09-07" version="1">MSKNKQFVVIGLGRFGESVAKTLYGLGHDVLAIDMDEDMVQEISDSVTHAVQMDATDESALRTLGLRNFDVAVVTIGSNIQASVMVTLLVKDLGVKYIIAKGQSDLHAKVLYKIGADRVVLPEKDMGVRVAHNLVSASILDYIELSPDYSIMEMKALEEWNGKNLTELKLRSRYGINVMAIKKDDDINISPSADEVISSDDIIVAIGSAEDLAKIEEIMAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GV83</accession>
    <name>A0A174GV83_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266090.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64759">
        <property type="protein sequence ID" value="CUO64759"/>
        <property type="gene ID" value="ERS852471_01961"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1499314at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="360" mass="42301" checksum="047F16B6F76EE1D7" modified="2016-09-07" version="1">MTVYLVNLVIVTIFSLLADIVVKDKYHYGKRKYNLLFLFIALLSLILVSGLRYKVGTDFAQYSEIYSVFGNQPISWGEQEFGFDALNKILYRINKNPQFFFLITSILINLGIVIFVREYSINLPLSMYFYITNYTYYVTMNGVRQYIAAVILALGFKFVLNKDFKRYVIVILIASTFHASAFIMIPVYFLAITDIKSIWNKGFSCLIGFAFVFYQPFVNIMFKFLENSSYAHYQSELSNLDDGANILRVIVWALPIVLFALRKKRAEEMFGEKSSIIFNFCFYGMCFMALAYRHKYFARLTMYFDIYYLLLFPMIIKLFNKKENRIIAYGMVVGYFLYSTFLLLSGDAWIYPYKYNLNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWL3</accession>
    <name>A0A174GWL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266122.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65456">
        <property type="protein sequence ID" value="CUO65456"/>
        <property type="gene ID" value="ERS852471_01979"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1536506at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="363" mass="42884" checksum="839A5C0C38194D06" modified="2016-09-07" version="1">MEDIQNQFVRILSDSLKEEKPSIYTDIKWEQVLELIERYKVEGIVYENIKNNDLTTIVSEEILNRLKIKVNLIEEDQKKVIVQLDKISKAFNNNEISFIVLGNLATKELYYYPEMRECNKIELLIQEEDTESVKALLFASNYKILEENKDEYKITFIDDKESELIIYYHLCNKNDENKELIIYERTVWKRAIKLELGQTEVLSLDYEDFAVRLCMQIEDNIYKGTNDFKELCDLAMLVQIKGKLVNWDSFLMKAGMYGAEKSSLIIFILCNKLLKVDIPKDFDIKKINNKKYVDALINEIFNDSFNKESKEEIAAMVCTDKEIEESNNLIIKYVMKTINKTKEWINELNSPVTREKLLEWMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0M7</accession>
    <name>A0A174H0M7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_1</name>
        <name evidence="5" type="ORF">ERS852471_02041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266254.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68434">
        <property type="protein sequence ID" value="CUO68434"/>
        <property type="gene ID" value="ERS852471_02041"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="35227" checksum="4DB8991778311A6C" modified="2016-09-07" version="1">MYILQIENLHKKYNNFEAVKGIDLNIKKGDIYGLLGPNGAGKSTLIKIISGLEKMTSGKVIFEERETNINKYKKNIGLLPQDIAIYHDLTARENVSFFCSLYGYRGRELKRRVNKALDFTGLLNVENKKSKEFSGGMKRRLNMACAIAHSPRLIIMDEPTVGIDPQSRNHILESVRRLNEEGATIIYTSHYMEEIDELCDNISIIDNGRIIVEGTKEYLKSTVVDEDICTIKLKKEIYNIKKHLSRIAGIQKVEVTENEIKCYYSKGMNIIPYIIYTITNNSGVIENIKNEIPTLEGVFLKLTGKQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5B5</accession>
    <name>A0A174H5B5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266244.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68250">
        <property type="protein sequence ID" value="CUO68250"/>
        <property type="gene ID" value="ERS852471_02036"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1810264at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="79" mass="8577" checksum="1FAA1598C9EA4DA8" modified="2016-09-07" version="1">MACGCGTHSKDGKAIVDRVREKGKADMKLNTPHIITCSCGEDFTMSTFVDVCPNCKMTYGVTPCSQNDKENIKPAGINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7N8</accession>
    <name>A0A174H7N8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266328.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70251">
        <property type="protein sequence ID" value="CUO70251"/>
        <property type="gene ID" value="ERS852471_02089"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1862459at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="212"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO70251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="294" mass="33076" checksum="51CE758F4A5ECA50" modified="2016-09-07" version="1">MGKLFIVISTFLLLVVIGVRNAKNNKRIFTVLNKIMKEINTTYIQLFKEKSKLRRSVQIILIIAAEIFIAISISTSVIRYMDTYMISTVDLLIKIGIIIVSLIVIHYSMGYILLITIKIHKFIYGVENKNVKVDLLLSYFIISTYFTALLLSPEEFESTYVLGLIGITVSYVLNMKVLIQLIRNPYNIKSKHEEETSYSRIIVAAILMVGLIVLNLFLGVCFINGAEPGAFSNSPNAFDLFYYTVITFTTIGYGDITPLTIGAKIISIIISITSVICLTIFLSTILSYKDNSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCW9</accession>
    <name>A0A174HCW9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mgrA</name>
        <name evidence="2" type="ORF">ERS852471_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266423.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72674">
        <property type="protein sequence ID" value="CUO72674"/>
        <property type="gene ID" value="ERS852471_02138"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="148" mass="17273" checksum="2A996A3D6F46C37A" modified="2016-09-07" version="1">MNNKNDEYFGKYISILHRQANVFYSKEFNKFGIGSGQYMFMIHLYRNDGISQEELSDIINIDKGTTAKAIKKLEELGYIERNKDSEDKRINRIYLTNKALEIKEEFLEGLMKWEDMLTSDLSDEEILYGLKILNKLTNNVSKKLGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HES3</accession>
    <name>A0A174HES3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266375.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71630">
        <property type="protein sequence ID" value="CUO71630"/>
        <property type="gene ID" value="ERS852471_02112"/>
    </dbReference>
    <dbReference type="OrthoDB" id="991466at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="207"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="408" mass="46678" checksum="13FAA65C5056D661" modified="2016-09-07" version="1">MIREAYINRMKEIALNVTQTRIDSIRKKDITKSGCRVYKDGYIGVSGSLGEPTEETWNEAIKNLENKVPYNFEVCKDRKRRRDLRECNMSSDEFLKKAEELLEIIRSEFPNFIFSNKIKSIETEITLKNDVGLEYVNLDKYYQTELIIKHKESVNVFDTAVQRCERQFDIEAIVKDVRDYLTAFDNIVEIPKETKIPVISNFYDLGEKVIEGLNGNDLYKGTSIFNNKLGKEVFSKDFTVYVDRSEENIDIPFFDAEGSVIENDRFCLIQNGKINFGYTDKKTSAEYNIPNTAAALANYDEVPSLYGQGMVESRIKVKSGDKTLSEILNGKEAIYTVIMSGGDCTNEGDFASPVQMAYLFKDGKIVGRLPEFSVYGNIYEMFGEDYLGQTADRCYFGEHAIVLNMNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFE9</accession>
    <name>A0A174HFE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71729">
        <property type="protein sequence ID" value="CUO71729"/>
        <property type="gene ID" value="ERS852471_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016905">
        <property type="entry name" value="Glycyl_radical_YjjI-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11230">
        <property type="entry name" value="DUF3029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04040">
        <property type="entry name" value="glycyl_YjjI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="41893" checksum="D8B61275C5B737D1" modified="2016-09-07" version="1">MDEVEAKLAIRLFLTQLDRTITDSFCHGNLGPKPTKAAKIILEVERELENAIPNLTLKYSEETPDDLAIEAIKTALVTAKPSFANHKMFTEDLGTYGIASCYNGLHVGGGAHTLVRMRLSTLASTATDIDDFFNDKLPNAMKCMAEYINERIRYIVEESTFFETNFLVKEGFISKDRFTSMFGLVGLAEAVNILLKAEKLEDKFGHCQEADDLGVRIMDFMEDFINNFQSKHCKVTNERLLLHAQVGIGDDINISPGSRIPIGEEPELWKHLKQTARFHKYFPSGVGDIFPFEVNSMNNPEFILNIIQGAFKEGMRYFSLYSSDADVIRITGYLVKKSEIEKLNRGEATLQDTVVLGQGQVKNGKVLERMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPN9</accession>
    <name>A0A174HPN9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mppA</name>
        <name evidence="3" type="ORF">ERS852471_02206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75098">
        <property type="protein sequence ID" value="CUO75098"/>
        <property type="gene ID" value="ERS852471_02206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="86"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="506" mass="57403" checksum="668C01323DF034E9" modified="2016-09-07" version="1">MYIDIERRVNLKKIFVVLGLFVVSIVFLLGFIDKSPTKQVRSEADIVYSINNIPSNFVTVGSLSKREQDIICAVSKGLVELDTNGELVPALADSVDIRDNGIEYDFKIRDDVYWSDGTKITPSDIAEFFREVITLEAEEDIEPLLNVFGVIDYRNGNKSFSNGVGITATDTNLILRLNSQDSNFLNELTKPQYRLRKSVILWEEIGNNYTTIPYSGNYSIADINSLNEITLKRNNTADSSLAKTIHMVNDDSEDLALAAFEIGQRDIVLNPPKSQLNRLSKEGKLVSIPSSKSVYLAFNKNNILSIDDRKEIYRLITKALEDYESDNKSLIKLADGSYFRDEEQDLSKLQDRKVMSSLGEEAEIPEVIYIACEESLLNKEMVDYISNWFAENTDITLVGSLLREEITSDISYYDMAILNLNADYNDKSEFYKVISPYISEELAEKVSIFNTVEEEKEILTQIEDNLFENYSVLPLIFYNDNIAVNTSIENISLDGNGNLKFEIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HVL6</accession>
    <name>A0A174HVL6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ispF</name>
        <name evidence="10" type="ORF">ERS852471_02265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266647.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77188">
        <property type="protein sequence ID" value="CUO77188"/>
        <property type="gene ID" value="ERS852471_02265"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="100"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO77188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="157" mass="16955" checksum="3723F643BA618675" modified="2016-09-07" version="1">MRIGMGYDVHKLVENRDLILGGVKIPYELGLLGHSDADVLLHAIMDSLLGASALGDIGKHFPDTDPKYKGISSIHLLKEVGKLLKDNGFEINNIDSTIIAQKPKMAPHIQGMRKNIADALNINIDQINVKATTEEGLGFTGEGKGISSQSICLLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HW65</accession>
    <name>A0A174HW65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266655.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77388">
        <property type="protein sequence ID" value="CUO77388"/>
        <property type="gene ID" value="ERS852471_02271"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO77388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="186" mass="19943" checksum="E6EBCE1E7A03DE14" modified="2016-09-07" version="1">MLGLLFLSFIQVGLFSVGGGYAAIPLIQNQIVNIHGLMTLPEFADLITIAEMTPGPISINSATFVGTRLAGLPGALICTLGCIIPSFIICLILAHYYYKYRNFGGVQTILASLRPAVVALISSAGLSILTLAIFQAEKQDIVLSNFRPIEFLLFVGGLFAIRKFKVNPILIIFGSGLIGTIAYMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I3R3</accession>
    <name>A0A174I3R3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA/RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_02369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266806.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81091">
        <property type="protein sequence ID" value="CUO81091"/>
        <property type="gene ID" value="ERS852471_02369"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="207" mass="23647" checksum="DEE1BCF143F70EFD" modified="2016-09-07" version="1">MKIIEMTGKTVDEALKNALHELNLTEDKVEFEVLEEGSKGLFNLIGTKPAKIKVTVKRDPALEGKNFLTNVLNSMGVTADIEVREENDTIFINLSGPKMGLVIGYRGETLDSLQYLVSLVVNKNHDVPYKKVVLDTENYRSKREETLKRVAQKTAYKVKKTGRPYKLEPMNPYERRIIHSALQSYNDINTYSEGEEPFRRIVVSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGG3</accession>
    <name>A0A174IGG3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotidyltransferase/DNA polymerase involved in DNA repair</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dinB_1</name>
        <name evidence="4" type="ORF">ERS852471_02444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266938.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84458">
        <property type="protein sequence ID" value="CUO84458"/>
        <property type="gene ID" value="ERS852471_02444"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="418" mass="47995" checksum="2AA4DB205C89ADEA" modified="2016-09-07" version="1">MDSCPERIIFHIDVNSAYLSWTAVKQLQYGENDIDIRTIPSIIGGDGENRHGIVLAKSIPAKKYNIQTGESIAESLKKCPNLKIYPPDYNLYMRCSNAMVELLKEYTPVIQRYSVDEVFMDVSHFKDKYMEKAYEIKLRIKEELGFAVNIGISHNKLLAKMASDFKEKDSVHTLFKNEIKDKMWPLNIRDLFMVGKVTEAKLLKLNINTIGELAQYNLEFLKPIFKSYASVIHNYANGIENSEVRASNYMEVKGIGNSTTTSKDIYTREEALKILLSLTETASMRLRKNNSMCSLIAVSIKTNGFFKFSHQRTLNNITDSTEEIFHQVTSVFDEMWNNQPIRQLGVRFSNLCSNEFYQRTFFDDKNIDKKRSLDRAIDNIRERFGDKAVFRSVFISSDIKPLSGGNGEDDYPMMGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IHJ7</accession>
    <name>A0A174IHJ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase factor sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sigH</name>
        <name evidence="3" type="ORF">ERS852471_02487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267027.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86664">
        <property type="protein sequence ID" value="CUO86664"/>
        <property type="gene ID" value="ERS852471_02487"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014218">
        <property type="entry name" value="RNA_pol_sigma-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016371">
        <property type="entry name" value="RNA_pol_sigma-H_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002939">
        <property type="entry name" value="RNA_polymerase_sigma-H_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02859">
        <property type="entry name" value="spore_sigH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO86664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24927" checksum="B72BA98A4279289C" modified="2016-09-07" version="1">MNEERDFNSVEYFYKCESEEQIVEEAKKGNKRAQEFIISKYENFVKVKAKSYFLIGADKEDIYQEGMIGLYKAIRDFNGEKSTSFRAFAELCITRQIITAIKTATRQKHIPLNTYISLNKPVSEEESDRTLLDIISSIRTTDPEELIISQEQKEFIEEEINKVLSDLEIQVLQSYLEGKSYQEIACDLDRHSKSIDNALQRVKKKLEKCLVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IJH0</accession>
    <name>A0A174IJH0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">ERS852471_02508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267048.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87443">
        <property type="protein sequence ID" value="CUO87443"/>
        <property type="gene ID" value="ERS852471_02508"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO87443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="180" mass="19488" checksum="8E10DA71D95F8036" modified="2016-09-07" version="1">MSRVGRLPIAIPTGVTVTVAEGNVVTVKGPKGELVKTMAKDINIAVEDNQVVVTRPSDVKEHRALHGLTRALINNMIIGVEKGFQKTLELVGVGYRAQLQGKNLVMNLGFSHPVEIKAVEGITFETPSATKVVISGIDKQVVGAVAADIRKWRKPEPYKGKGIKFEGEVIRRKEGKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IM89</accession>
    <name>A0A174IM89_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">ERS852471_02503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876949.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87246">
        <property type="protein sequence ID" value="CUO87246"/>
        <property type="gene ID" value="ERS852471_02503"/>
    </dbReference>
    <dbReference type="GeneID" id="66300464"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO87246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="122" mass="13247" checksum="787DB8D96D26FBBC" modified="2016-09-07" version="1">MIQQQTLLKVADNSGAKEIMCIRVLGGSKRKFGNIGDIIVASVKSATPGGVVKKGDVVKAVIVRSVRGLRRADGSYIKFDENAAVIIKDDKQPRGTRIFGPVARELRDKEFNKILSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IN29</accession>
    <name>A0A174IN29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267094.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88782">
        <property type="protein sequence ID" value="CUO88782"/>
        <property type="gene ID" value="ERS852471_02539"/>
    </dbReference>
    <dbReference type="OrthoDB" id="36859at31979"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO88782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="38352" checksum="690D33D75FB6F6A5" modified="2016-09-07" version="1">MEIFKTKLRENKKFILIIFLVLLLAFISIAFIYNYKFKNNNSKSNTFDYIVEEINAINNSIKDYPTEFNLNNESIVTSLRNNINNLETIKNDLRALIILDDYTRDISSKILSSIESAQTLYNCCISSLEYQNISSSSEYVTKINEQQFDLLKSYSDLNYLGIDIKFNDSSLVFFDKLINYLNNLEIVTKKNNISTSQGEAFMKNFKTAVNNFSELVEDLEPAISKVREDNRSFDSILNDIADKESKFLNIKSNINSISIPEGYLSYYNALIDTFNLYSNYLKTLKVAIIFEKSSTNYKDNKDSIDKNYENAFSKLDDVNDSLNSLNKSLENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IYF2</accession>
    <name>A0A174IYF2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267160.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90627">
        <property type="protein sequence ID" value="CUO90627"/>
        <property type="gene ID" value="ERS852471_02573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="114" mass="13224" checksum="321750C1C9BC2FD7" modified="2016-09-07" version="1">MKKKKVVLAVGLIGIILIICSFYLNCYFVQRSINGNNEDGIKRSISYLHKDYIDKSEEINIIDEFNYDTDKVVFFRNDKLTGIAKFNKDSRGKYKIDFVETLDTNNIRKISKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J9Y4</accession>
    <name>A0A174J9Y4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoVB</name>
        <name evidence="8" type="ORF">ERS852471_02662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267317.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94438">
        <property type="protein sequence ID" value="CUO94438"/>
        <property type="gene ID" value="ERS852471_02662"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014249">
        <property type="entry name" value="Spore_V_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02900">
        <property type="entry name" value="spore_V_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="357"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO94438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="499" mass="55271" checksum="A32B53BEE5A9314A" modified="2016-09-07" version="1">MEKDNFFKNSFFLTAANITTGILGFIFSIYLSKLIGPEGIGLYGLVMPIYNLFISLMTAGIIAAISQRAAIYTSKREYNNLFKTINTVAFFNIIWSVAIGVLVFILAPYISEYGVKDMRTLNAIRVTCPAMVFIALSNILKGFFYGTSKITVPAFIDILEKAMRIITIALLIFIFKANTLSSLVTLAYVSLAIGELQSLLLLYAYYKHIVKKIPPSYEKPERKAQLLFNVLAVSFPLCLNGFMGNIFSAMSTLVVPRRLVSIGLEYSTAIAMIGKFNGMALTIVTFPLIVVNSISTLLMPDLSETLSKGEYYSASVRIRKVLKIAFLLGIATCIICLLIPDSLGKMFYGRDDLGLYIKVCALSAPLFFTSSTMFGILNGLNRQSIILRNSLITSSIELISLYILTGIKSINVFSTAITLFITSIISLIINLHEIKKHIDISLSSINIIIFSLIGLLTYLLLRLLTNTILSDLFIVKNIIIIILTFGLFAYFSGFGIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JGN7</accession>
    <name>A0A174JGN7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding/permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_02699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267385.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96355">
        <property type="protein sequence ID" value="CUO96355"/>
        <property type="gene ID" value="ERS852471_02699"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO96355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="556" mass="61420" checksum="437447F6FE7D3679" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JI51</accession>
    <name>A0A174JI51_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ORF">ERS852471_02766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267505.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99392">
        <property type="protein sequence ID" value="CUO99392"/>
        <property type="gene ID" value="ERS852471_02766"/>
    </dbReference>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO99392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="499" mass="58627" checksum="B3D53704B3BECD1E" modified="2016-09-07" version="1">MNRSAGVIMHISSLPGKFGIGTFGQEAYDYADFLYKSGLKYWQILPLGQTGYGDSPYQSFSAFAGNPYFIDFDLLAKDNLLREDEYLNENYGDNKNYIDYGLLFKIKYEVLRKAYNNFINNESSHLREEFEKFREENKWWLEDYALYMAIKNHFNLVSWQDWDDDIKKREVEALEKYNVLLKDNIEYWEFIQYLFFKQWNDLKKYVNSKGIKIIGDIPIYVAEDSADVWSNPESYLIDKETLKPISVAGCPPDAFSATGQLWGNPIYDWEYMDKEGYSWWIKRVRESLKLYDVVRIDHFRGFESYWKIPYGEETAINGEWVKGPGMKLFDAVKEALGEVNVIAEDLGFLTVEVKEFLEDSGFPGMKVLQFAFDEREESNYLPHTYNNNCVAYTGTHDNDTFRGWYDLTAPRNDVKYCKEYLALSDEEGYNWGFIRGVWSSVSDLAIATMQDFLDLGNETRINMPSTLGNNWKWRISEGSYDDELAEKIYRYTKMYGRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JMI5</accession>
    <name>A0A174JMI5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:dicarboxylate symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tcyP</name>
        <name evidence="8" type="ORF">ERS852471_02804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267572.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00994">
        <property type="protein sequence ID" value="CUP00994"/>
        <property type="gene ID" value="ERS852471_02804"/>
    </dbReference>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP00994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="469" mass="50100" checksum="F1CD73263BEF2140" modified="2016-09-07" version="1">MNSTFFQQFLMISDFKTVLFIGILVLIFFGISFLGKGKTKLKFSTRMILSTIIGLLLGLLIQLVAKFPANPSEITWISEVSKWYGLIGNGFIDLLKMLVVPIVLISIIRVIMNMTQDDNIGKLTGVSIISLLSITALSAIIGVIVANIMKLGVGANVIAGSATIKEIEPIADTLRGLLPSNIVDSMAKGNVIAIVIFATFIGLSIRRLKVKKYDKVKVFIDFIEASYTIITSVAITIIKFMPYAVVALLSNVIASRGISSLKEVFGFIIAIYISTAIAFILQMLIVSLFKLNPFKYVKNVLEALVLAFTSRSSLGTLPVTIKVLTENAGIKEGTSTFVGSLGSNMGMNGCAGIYPALMAVTLANMVGRPLDISFYATLIIVIVISSLGIAGLPGTAIMAVSVVISGVGLGEFFPLAAGIIAIDPILDMARTMINVNGTMVSAVITSSITGDLDKNIFNNDDKSNSNIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQ13</accession>
    <name>A0A174JQ13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose ABC transporter</fullName>
            <ecNumber evidence="6">3.6.3.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC_3</name>
        <name evidence="6" type="ORF">ERS852471_02763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.20" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267499.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99265">
        <property type="protein sequence ID" value="CUO99265"/>
        <property type="gene ID" value="ERS852471_02763"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO99265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="369" mass="41414" checksum="E64D39476B5B0D19" modified="2016-09-07" version="1">MANLSLKHIYKVYQGDVTAVKDFNLEIEDKEFIVFVGPSGCGKSTTLRMIAGLEDISQGELYIGDKLVNDVEPKERDIAMVFQNYALYPHMSVYDNMAFALKLRKVPKAEIEEKVHEAAKILDIEHLLKRKPKALSGGQRQRVALGRAIVRNPKVFLMDEPLSNLDAKLRVQMRTEIIKLYRKLETTFIYVTHDQVEAMTMGTRIVVMKDGVIQQVDTPQNIYNNPANLFVAGFIGSPQMNFLNGTIENDGDGLVAVFNGNRIDIPADKAKVLKADGYVGKEVIFGIRPEHISDKDELIKDNPHSVINGNVEVIELMGAESYIYTKCGDNNMNVRVEGTTSLKIGQEAKLFLDANKLHVFNKETELKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JT18</accession>
    <name>A0A174JT18_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tktN</name>
        <name evidence="2" type="ORF">ERS852471_02836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267639.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02923">
        <property type="protein sequence ID" value="CUP02923"/>
        <property type="gene ID" value="ERS852471_02836"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1543182at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP02923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="29581" checksum="3007200C13CC1C65" modified="2016-09-07" version="1">MNTEELKLMAKNIRADIVTMLTESASGHPGGSLSAADIVTTLYFKEMNIDPSDDKNPNRDRFVLSKGHAAPVLYSALARKGFFDVEELKTLRKFGSRLQGHPSMKCLPGIDMSTGSLGQGISTAVGMALAGKLDNKDYRVYTLLGDGELEEGQVWEAAMCGAHYKLDNLTAFIDFNGLQIDGDITKVMNPTPIDKKFEAFGWNVMIIDGHNIDEIIDAIEKAKNHKGQPTAIVCKTVKGKGVSFMENEAGWHGTAPSKEQCEKALAEIGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K101</accession>
    <name>A0A174K101_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03687">
        <property type="protein sequence ID" value="CUP03687"/>
        <property type="gene ID" value="ERS852471_02854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP03687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="24227" checksum="65803EA4C32D245B" modified="2016-09-07" version="1">MNTIKAAIFDLDGTLVDSMWVWEQIDIDFLKSKGYTPPKDLKDDITHLTFRQTAEYFKDRFNLSDSIDEITDTWNNMAYDFYSSKVKLKEGVIPFFNKLKSLNIKIGLATSNSLPLLEATLKNNGIYHLFDAITVTDEVKKSKENPDVYLLCANKLNVSPKNCVVFEDIIAAVNGAKLAGMKVIGIYDKASEDQKEILTQTCDRYILNYNELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7Y7</accession>
    <name>A0A174K7Y7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
            <ecNumber evidence="3">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">npr</name>
        <name evidence="3" type="ORF">ERS852471_02955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267852.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08234">
        <property type="protein sequence ID" value="CUP08234"/>
        <property type="gene ID" value="ERS852471_02955"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="463"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP08234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="541" mass="58171" checksum="4D6240AA9CE7D3AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KHD5</accession>
    <name>A0A174KHD5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268005.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11544">
        <property type="protein sequence ID" value="CUP11544"/>
        <property type="gene ID" value="ERS852471_03031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="16156" checksum="9F166EC59C90CA04" modified="2016-09-07" version="1">MFNLIYVILGLYFISLVVTVLKEYYMKMKSTRTKEKTHLVTKLFSKFKNTLSEKNNIFVLKHNKKELSEDTIEFNPIVLSKEKRHLAFENAKYMCEECGSIANIDVYNINSSGSDENLKVLCKKCSEEYCAKMNLHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KJ54</accession>
    <name>A0A174KJ54_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic sulfite reductase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267935.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10257">
        <property type="protein sequence ID" value="CUP10257"/>
        <property type="gene ID" value="ERS852471_02994"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1092632at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014259">
        <property type="entry name" value="Sulphite_reductase_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02910">
        <property type="entry name" value="sulfite_red_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP10257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="39245" checksum="9406325175D7C508" modified="2016-09-07" version="1">MKVKIPVKRFDEILVALKNYYRIFAPVSIPYRGTYSDTDVIRYEEINSIKEVEFGRKSQFSAKDVVMPVTETLFYFSEDEYKIPKIDERKILVFMRSCDIHGLDRIDNVYLRNGSEPDFYYKRLRDKVKIVAMGCEESFRNCFCVSFNTNKTDNYSLGIKVDKEDVYIEIKDKEFEDIFNGEKVDFNINFVESNGVYVNLPKDIDPLKVSQADFWRDYDYRCIACGRCNFSCPTCSCFTMQDIVSVDNPKVGERRRVGASCQVEGFTTMAGGHDVRQKNGDKMRFRTLHKMYDYGKRFGVQMCVGCGRCDDVCPQYISLSTAMNRVTDYVRDMEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KP13</accession>
    <name>A0A174KP13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein Cas5, hmari subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cas5h</name>
        <name evidence="3" type="ORF">ERS852471_03070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268081.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13733">
        <property type="protein sequence ID" value="CUP13733"/>
        <property type="gene ID" value="ERS852471_03070"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815464at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013421">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_HALMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02592">
        <property type="entry name" value="cas_Cas5h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP13733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="28994" checksum="EBFE3BE8BDEF75F6" modified="2016-09-07" version="1">MKVLKFRLYGDNAFFKKPDVNTYLYFTYSNIHKVALLGILGAIVGYKGYNQMSKTDKYPEFYEKLKDIKVAIEPEEGSRGDFYKKVQVFNNSIGYYNKDKDERPCNLIVKEQWLEKPSWNIYVLVDSKDTEKICDYITNYKSIFIPYLGKNDHIANIDEIEIYESEKAADEIESIDSLCPKSYVNFGDSVADMNYMPYKYKENLPIRLNEKTNMYEYETFIYTNMEIDDINTDEIYTVGNKNIAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQW5</accession>
    <name>A0A174KQW5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrrB_4</name>
        <name evidence="2" type="ORF">ERS852471_03078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268097.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14423">
        <property type="protein sequence ID" value="CUP14423"/>
        <property type="gene ID" value="ERS852471_03078"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1871389at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP14423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="117" mass="13612" checksum="3742A7109306631F" modified="2016-09-07" version="1">MDYFSEANKLYNLKEYNKAIDLYKKSIETKENTACAYYNAGVCFIKLKNFNAAIDMIKNALSIQKESKYFFNLAYCYAMKEDTNKALIYFNRAWSLDSTDKDCEKAINLIMANKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZ13</accession>
    <name>A0A174KZ13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15098">
        <property type="protein sequence ID" value="CUP15098"/>
        <property type="gene ID" value="ERS852471_03093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP15098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="51" mass="6146" checksum="A497FCD3E501A343" modified="2016-09-07" version="1">MQRKKIDIALANTVAKKMIIDGDPWDEIMRETHLRLKDLKRIQRDQIDTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L3Y5</accession>
    <name>A0A174L3Y5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17531">
        <property type="protein sequence ID" value="CUP17531"/>
        <property type="gene ID" value="ERS852471_03142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP17531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="42" mass="4811" checksum="3F1AFDC2038266DD" modified="2016-09-07" version="1">MRIGKIIIPTEVLCARFLLTINVELKEIIIILEKKECISPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L600</accession>
    <name>A0A174L600_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon dioxide concentrating mechanism/carboxysome shell protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pduA_1</name>
        <name evidence="3" type="ORF">ERS852471_03177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268265.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19553">
        <property type="protein sequence ID" value="CUP19553"/>
        <property type="gene ID" value="ERS852471_03177"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP19553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="9220" checksum="F4E8A7D3924F5C42" modified="2016-09-07" version="1">MKQEALGMVETRGLVAAIEAADAMVKAADVTLIGTEKIGSGLVTIMVRGDVGAVKAATEVGASAAANLGELVAVHVIPRPNGDVEKILPTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LB44</accession>
    <name>A0A174LB44_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_03218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268338.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21704">
        <property type="protein sequence ID" value="CUP21704"/>
        <property type="gene ID" value="ERS852471_03218"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1467202at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF1232" evidence="5">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP21704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="319" mass="36152" checksum="C58B84655EC8824D" modified="2016-09-07" version="1">MNITNIAVGLTGGDLLSILDDFVSIEGLTIYSIDMSDCILIRGNFKKGISIDFECGLRVKSIENDMIQGEICKFRVLNIGIASFLRKIALKFALKSFADKGIYYKDGKVNIQYKYILKDVPYIDFNINDLRLLDNKLVVGVNNVSISLGGELKKEVKLFKEEQNEEEVREAEERGKTEDLYTVGREKVSEKLPERVKKYSDYIFVIPDIAALLTRLLKDNRVSIKTKLIISGSIAYIVIPTDIIPDKIPFIGKVDELAVAFFALNRIVKDVPLHIILENWQGKNDIILVIKNIIEYVTNFTAAQNVETLYEFIEEVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LVQ6</accession>
    <name>A0A174LVQ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000039">
        <property type="protein sequence ID" value="CUP26068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268462.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26068">
        <property type="protein sequence ID" value="CUP26068"/>
        <property type="gene ID" value="ERS852471_03291"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1853531at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011737">
        <property type="entry name" value="CHP02206_TP0381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09529">
        <property type="entry name" value="Intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="30992" checksum="AFE913ED1EA82619" modified="2016-09-07" version="1">MYLLNQFWAPRKVYNPCGMFTYGHIVLLLIAMLILSILLLNSRKITKSQIKNLTKVLSVFITILEAIKIYFNFYYGYTWINAWFPMSYCSLFIYALWLSGYGKGKYKKMGEVFIAGVAIVAGGTYLLIPSTSLTMYPMWHYLCMYSMLFHTLMVYMGILYLWKKEIKLDIKGYRMYSIFFLAFSTIAIILNNVFESNLMFLKKPSTIPVPLLHTLYNNTKWGYTFLVFSVYLFIPYGVTSYLSRAIKKAKLNRQNDCDKEVIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M0R1</accession>
    <name>A0A174M0R1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ywqD_6</name>
        <name evidence="10" type="ORF">ERS852471_03314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000043">
        <property type="protein sequence ID" value="CUP27560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268492.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27560">
        <property type="protein sequence ID" value="CUP27560"/>
        <property type="gene ID" value="ERS852471_03314"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP27560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="23987" checksum="D94869D85EB4DA4D" modified="2016-09-07" version="1">MFVVEKQPKSIAAESYRTLRTNIQYSSFDKEYRTIVVTSSELGEGKTVTSGNLALALAQGENKVLLIDCDMRKPSIHKNFRISNESGLSELLLHKKTMENISWKYNDNLTLIPAGKVPPNPSEMLGSRVMGTFLDEMKKHFDYIVIDTPPLGAVTDAQVLSTKVDGTILVVKAGSTKKDVVMNSVNLIKKVNGNLIGTVLNGVEKSKNKYYYYYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEF7</accession>
    <name>A0A173XEF7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_2</name>
        <name evidence="6" type="ORF">ERS852471_00023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262696.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50063">
        <property type="protein sequence ID" value="CUN50063"/>
        <property type="gene ID" value="ERS852471_00023"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="304" mass="34764" checksum="383470567041E1C1" modified="2016-09-07" version="1">MNKEKLLEIKSLKQYFTLNNNKIIKAIDDVSLDIYKGEFLGLIGESGSGKSTLGKSIVGINKITGGEIKYDGITISDKKSKRIKREIISKKIQFIFQDSTSCLNSRMTVKDIIEEPMKLQKLYKSKKEREKVVYDLLDVVGLDRSSINKYPYDLSGGQRQRVGIARAISTKPEFIIADEPIASLDVSMQAQIINLFKKIKKNNNLTFLFISHDLSMVRYISDRIAVIYKGKIVEVAPTDELYSNPIHPYTKMLIAANLQEDNSSNKKDGFKNKDYDIKYNENYNEDAKWIEVSKEHFVLIDKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEL8</accession>
    <name>A0A173XEL8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2812)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262698.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50123">
        <property type="protein sequence ID" value="CUN50123"/>
        <property type="gene ID" value="ERS852471_00024"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1869635at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021359">
        <property type="entry name" value="DUF2812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11193">
        <property type="entry name" value="DUF2812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="427" mass="50118" checksum="442B3C412B71CE70" modified="2016-09-07" version="1">MVIGNRKKVLFKIVPYEYRSLELYLEKMALKGWKFEDIQGEFLSFVKIDPTQIRYWVDINDTNKIRNIEDTIKNGGTNKLGWNLIYRYNEIDIYSREDGVEEVHEEINQKEKFKDIAKLSLKNISMTLITVFLLAVTTLSDEFVNVIVNDDKIIMLIITTMIIVYQLTHITSFVTWYIRGKKSLRRNEEVSYKIHWLSKIRIVINTVVIVSGITALIYLGILTPDNSINEIIGVAMFLLVILIIINLVGKNSGSVSKKRRIDIFNIIGLVLLISILIGRNYIHKDTNYNNNYNLNKELNLTLEDFNDKSVNAGRNYINENKGTFASQLWFYDEGSNGYLDYNFFESNYKWIMDKYLEDRIKWINTLGNSSVEKVNYNEAVTLYTLQERNFYMLVSEDKAIDFINLNYRYDKEEFINKVYEEIFLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEQ7</accession>
    <name>A0A173XEQ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M42 family protein</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ysdC_1</name>
        <name evidence="9" type="ORF">ERS852471_00025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262700.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50163">
        <property type="protein sequence ID" value="CUN50163"/>
        <property type="gene ID" value="ERS852471_00025"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN50163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="38278" checksum="EAF34203BC51FBFF" modified="2016-09-07" version="1">MFKFNEEYVIQKLKELLEIDSTTGYFRLIQNYLVNEMEELNIPSEEVHKGGLIADIGGEGEPLVIMAHGDDIGLMVRYIKDNGALVVTNVGGLREEDATGVICRLHTRKGHIYTGCVRRVHSCAHVRPDSDNNAPLNYNTNVEFVLDEDVKCRQDVLDLGIRVGDIIALDAGFHMNNGYITSHFIDDKACIAVLLGVMKYIKDNNIVCKRNVKAFFTMFEEIGHGGAWLPDGTKDIIALDIAPVSPTQVSSEKKVSLFAKDSRFPYHYEMLTELVEAAEKVGADYEIDVFTPRYGTDSDFAITAGNNVRHAALGPGTSGSHGYERTHIDSLNNMYQLLLQYIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJZ1</accession>
    <name>A0A173XJZ1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapE</name>
        <name evidence="2" type="ORF">ERS852471_00046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262734.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51346">
        <property type="protein sequence ID" value="CUN51346"/>
        <property type="gene ID" value="ERS852471_00046"/>
    </dbReference>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="190"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="48752" checksum="EED793C15672E030" modified="2016-09-07" version="1">MNNLDKNTIAKNLSEMIQVNTIKTDDMSQYEIFQNLLEELYPTIHAKGEKVIIAGSLLIKIKGKNSNLKPMLLMSHTDVVEADGVWKHSPFSGDIADDCVWGRGTVDTKGALCAFLEATEDLLKEGFVPESDLYLASSIDEETLGVGAKKTVEYLKSKGVKLGIVLDEGGAIIESPMPGLTGYYAMLGIMEKGYANVEFIAKSLGGHASTPTNNTPIARLASFVNDVNTKSPFKKELTKPVKDMFKEMSKYMANPYKSLFGNVELLSPILKSVLPKVSSQANAMLTTTCAFTMASGSKAPNIIPETASVTANMRVMVHQPLQESLKIIKNVAKKYDIEMKVLYSHDCSKVTDVKSDGYKYICNCITNTFEDVKPVPFIVLAGTDARHYNEICDCVVRFAPLRLNKQQLNSPHGLDENISIDALYGASKFYRYFIENYKGVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRR2</accession>
    <name>A0A173XRR2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallophosphoesterase</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262839.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54359">
        <property type="protein sequence ID" value="CUN54359"/>
        <property type="gene ID" value="ERS852471_00105"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN54359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="375" mass="42987" checksum="413F436ABE1E3211" modified="2016-09-07" version="1">MNILYFIIPALLMILLSIYLYYYIARALRRVKVDVKKNRVKLIIIALVLIIMYFSLRDLGIGIVVLLHIVVLALVMDLLNYIFKIASKRNTIAFNKWRTVYESGIVPIILTAIILAYGYWNMNDIVEKGYKIYTNKNIRDEGYRVAMISDLHYGTVMNREKLQAVCNDIEEAEPDIVVLCGDIVDEKTTVEQMKEATEILGDIKSKYGVFYIYGNHDDARYSSIPSYTKDELKNELLSNNIHVLVDESYEINDDLVIVGRDDEGFSKEEGRKSSEDLIANIDKSRFILLLDHQPSELNLNSSLGYDLQLSGHTHKGQIWPAGLISELFNFNELEYGYKKIGDYEIIVSSGISGWNYPIRTGSKSEYLIIDIEKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XT41</accession>
    <name>A0A173XT41_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262803.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53518">
        <property type="protein sequence ID" value="CUN53518"/>
        <property type="gene ID" value="ERS852471_00086"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2050907at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11532">
        <property type="entry name" value="NTP-PPase_COG4997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038735">
        <property type="entry name" value="MSMEG_1276-like_NTP-PPase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="12145" checksum="A07458D0F42FD416" modified="2016-09-07" version="1">MKNYNKLVRDLIPEVIKADGKECEIEIAKDEEKTALLEAKLMEEVNEYLQDKNLEELADVMEVLFGLAHNLGYSEEDLINMRNEKLKARGGFKKGIVLKGVYKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y188</accession>
    <name>A0A173Y188_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262977.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57931">
        <property type="protein sequence ID" value="CUN57931"/>
        <property type="gene ID" value="ERS852471_00178"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="242" mass="28420" checksum="765E78D03A42CEAD" modified="2016-09-07" version="1">MKKIAAFFDIDGTIYREGLITEVFKKIIKYELVDEEKWYKEVRPAYLLWDKRQGDYDTYLLKMVDIYVEAIKGISKEQIEHVAKKVIEQKGDRVYTFSRERIKWHQEQGHIVIAISGSPYELVKEMSQKYNMDDFKGTIYISDKNNNYTGDVIPMWDSESKEKALLEMKEKYNIDLSASYAYGDTAGDYTMFKLVGTPYAINPTKELLHKITNDKEINDKINIIVERKDVTYKLTTDNLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7B8</accession>
    <name>A0A173Y7B8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263019.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59117">
        <property type="protein sequence ID" value="CUN59117"/>
        <property type="gene ID" value="ERS852471_00200"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2003386at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN59117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="7374" checksum="42F44D6D4F64A429" modified="2016-09-07" version="1">MEIEIKLKNSKTPLIYKGDRIDILDFEMNGVKYKQIRCFKKGFSKSELVLNELILNIKEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKH4</accession>
    <name>A0A173YKH4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">iscS_1</name>
        <name evidence="7" type="synonym">iscS</name>
        <name evidence="10" type="ORF">ERS852471_00263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263155.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64484">
        <property type="protein sequence ID" value="CUN64484"/>
        <property type="gene ID" value="ERS852471_00263"/>
    </dbReference>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
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        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="4"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN64484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="394" mass="43446" checksum="71A4AB5F060CC46F" modified="2016-09-07" version="1">MRTVYMDYAATTYVKPEVLEEMMPYFTQKFGNPSSFYGISRETKMAIDKARGQVAKALNCDVNEVYFTGGGSEADNWAIKGIASAHRKKGNHIITTKIEHHAVLHTCEYLEKNGFDVTYLDVNEEGFIDLEELKNAITDKTILVSIMFANNEIGTIQPIKEIGQICRERKVFFHTDAVQAVGNIPVDVKEMNIDLLSLAGHKIYGPKGIGALYIRKGIKIDNLIHGGGQERARRAGTENIASVVGLGKAIELATEDLQCHMEKLSSLRDKLIDGILEKVPYSYLNGPRGDKRLPGNVNVRFEFIEGESILLSLDFEGVCASSGSACTSGSLDPSHVLLAIGLPHEKAHGSLRLTLGDGSTEEDVDYVIEVLPGIIERIRNMSPLWSDFVKKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQ63</accession>
    <name>A0A173YQ63_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsI/penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ponA_1</name>
        <name evidence="3" type="ORF">ERS852471_00280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65346">
        <property type="protein sequence ID" value="CUN65346"/>
        <property type="gene ID" value="ERS852471_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
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        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
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        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="244"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN65346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="541" mass="60556" checksum="2DA572952D460F0A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YY23</accession>
    <name>A0A173YY23_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">ERS852471_00325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263267.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67865">
        <property type="protein sequence ID" value="CUN67865"/>
        <property type="gene ID" value="ERS852471_00325"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="18241" checksum="7DA9709F61AF7EDF" modified="2016-09-07" version="1">MKVAIYPGSFDPITNGHLDIITRGSKIYDKLIVGVLVNIDKKGLFSIEERVELIKKVTMHLPNVEVICFNGLLVDLARKYEAKVILKGLRAVSDFEYEFQMALMNSQLDPNIETLFMMTSSEYSYLSSSSVKQVAKFGGNISGLVPDEIITEVYNKIRDLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYT0</accession>
    <name>A0A173YYT0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPF0122 protein ERS852471_00340</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0122 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263291.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68659">
        <property type="protein sequence ID" value="CUN68659"/>
        <property type="gene ID" value="ERS852471_00340"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2008796at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00245">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40083">
        <property type="entry name" value="PTHR40083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN68659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="13040" checksum="A537C00BC2744F70" modified="2016-09-07" version="1">MEDRVEISLLMDLYGALLTEKQYSIMDLYYNEDLSLAEIAELNQTSRQAIHDLIKRCYKQFLTYEGKLMLLKKSLEREKKIASLLDDIDMKYSIDKIDYDRYKEILEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZR7</accession>
    <name>A0A173YZR7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ffh</name>
        <name evidence="10" type="ORF">ERS852471_00341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263293.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68716">
        <property type="protein sequence ID" value="CUN68716"/>
        <property type="gene ID" value="ERS852471_00341"/>
    </dbReference>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN68716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="449" mass="49502" checksum="D5AB2FFCCA2A19E3" modified="2016-09-07" version="1">MAFEGLGEKLQSTFKKLRGKGKITEKDIKEAMREVKLALLEADVNFKVVKTFVKNVSEKCVGSEVLESLTPAQQVIKIVNDELTDLMGGSESKLEFASVGPTVIMLVGLQGAGKTTMCGKLALQLRKNHNKKPLLVACDIYRPAAIKQLEVVGKQIDVPVFQMGDKVSAVEIATEGIKHARENGNNVVIIDTAGRLHIDEALMTELEDVKKAVNPSEILLVVDSMTGQDAVNVAENFNNSLDLTGVILTKLDGDTRGGAALSIRHMTSKPIKFIGVGEKMSDFEVFHPDRMASRILGMGDVLSLIEKAQEAIDEKEAKELGQKMMENDFTYDDYLTAMEQMKKLGSLSKIMEMIPGVPKEMKDIDFDASEKQLGRVKAIIYSMTPKERKNPKLLAGSSSRKKRIAKGSGTSLQEVNKLIKGHEMMRKQMKQMKSLTKRSKKGLFGKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z1T5</accession>
    <name>A0A173Z1T5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70234">
        <property type="protein sequence ID" value="CUN70234"/>
        <property type="gene ID" value="ERS852471_00367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="38" mass="4362" checksum="F85A5807E58596D6" modified="2016-09-07" version="1">MVKKNKGAKSKGKESLKSKEEVDSIVAYRNYYPNDKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z763</accession>
    <name>A0A173Z763_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional protein biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase BirA</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">birA</name>
        <name evidence="2" type="ORF">ERS852471_00382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263368.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71035">
        <property type="protein sequence ID" value="CUN71035"/>
        <property type="gene ID" value="ERS852471_00382"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="29858" checksum="BC7B84D78E18D437" modified="2016-09-07" version="1">MDNILTTELNNFKLLYPNIEFYFFEEIDSTNNFCKSLANKGFDKPTLVLSDKQICGRGTKGRNWLSPKNKGLWFSLLLKPDFSTKFLSIIPILTATAIYETLLEFDIKATIKWPNDIFIKDKKLGGILTESNISNEKIDYLIIGIGININLDITDFDLELQNKATSLKIAYGNDFNRFKILNTFIKKFSNIYSDITEDKIISILKIYKANSCILNKEVSLHYNNTYEIVTPIDIANDGSLLVKDSNNIIKQIYSGEVSLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z923</accession>
    <name>A0A173Z923_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yeiH_1</name>
        <name evidence="8" type="ORF">ERS852471_00395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71678">
        <property type="protein sequence ID" value="CUN71678"/>
        <property type="gene ID" value="ERS852471_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN71678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="39821" checksum="4ACBF30A8503E1B2" modified="2016-09-07" version="1">MNICKVLNIPYFFNMSNENNKNQNSFIKHALQILPGFLVCVVIAIVSKIIAKLFLPTLGAATIAIIIGIIVGNTFGRKEYLNKGTKFSEGTLLSISVVLLGGTLNISQLLDLGIRGILFIILLMLMTLFGTIWVGRYLKFGEDFVLLMASGNAVCGSSAIASTAPVINAHSRDKGIAITMVNVTGTVLMILLPLLTSFLYNNETFRTSAFLGGILQSVGQVVAAGSMVSEQVKEQATIFKIVRIVFLVVVVFLLAALKKKSTVKGVEAVEEEIHSHNHQSRIKIPWYIIGFFITCALYSLNIIPHSLTHTLKELDNFIEVIALAGIGMRVYFKDLIQQGPKASMYCVFIALIQIISAIVLIGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZM66</accession>
    <name>A0A173ZM66_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">abgB_1</name>
        <name evidence="3" type="ORF">ERS852471_00485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263545.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76285">
        <property type="protein sequence ID" value="CUN76285"/>
        <property type="gene ID" value="ERS852471_00485"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="377" mass="40957" checksum="58A5350E814BEDFC" modified="2016-09-07" version="1">MKEILFQEGTKIKERLCEISDYIYENPELGNEEYKAVEVLTKLLKEHNFSVEEKYLDMDTAFKATFDSGKPGLTVGYLCEYDALPGIGHGCGHNMIGTISAGAGIALSKIIDRVGGKIIVYGTPAEETNGAKVIMVEKGAFDELDCAMMVHPNDKTYASGTSSALYPIQFTFKGKTAHAASCPEQGINALNAVIQLFNGIDALRQHVTKDVLMHGIITEGGVAANIVPERAVAQFYIRAAKKATVTEVLEKVKNIARGAALMTGCELEMDRYELPYDDLNTNEVLSEAFNENLRSLGITEIHAPKTGGGSSDIGNVSYVTPTIHPYISISNCEIRGHSRELAKATTESLGHERLLTAVLALAYTGYDVLTKKVILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSM3</accession>
    <name>A0A173ZSM3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yabI</name>
        <name evidence="2" type="ORF">ERS852471_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263593.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79452">
        <property type="protein sequence ID" value="CUN79452"/>
        <property type="gene ID" value="ERS852471_00500"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="18597" checksum="F4E7F9A37801B319" modified="2016-09-07" version="1">MSSINEAIVYFETYGLWFLFIIVYLEYLNLPGLPAGIIMPAIGALVAQSKYNFLFVLIISVIAGAVGSVCLYYVGYFIGNPVLHWIYSKFPKTRKSVDKVTMYCEKFGNKGLFICRLLPVARTLVSLTSGILRDGIVSFILYSVPGIAIWNAVTIMSGYLASKAIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSY6</accession>
    <name>A0A173ZSY6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-l-methionine hydroxide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN78933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263581.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78933">
        <property type="protein sequence ID" value="CUN78933"/>
        <property type="gene ID" value="ERS852471_00491"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1262717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN78933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="31320" checksum="35D55FDF2A66AA4C" modified="2016-09-07" version="1">MKNALVFQTDFGLADGAVSAMYGVAHGVDSELRIFDLTHDIPQYNIWEASYRLIQTVTYWAKGTVFASVVDPGVGTDRKSIVAKTVTGHYIVTPDNGTLTHVKRMCGIVEAREIDENINRLPNSGASYTFHGRDVYAYTGARLAAGVIDFEGVGPKINVDEIVELPTVAAAKDGDCVTGTIDVLDVRFGSLWTNISRELFMGSGINYGDRVEVSIKNDTREVYRNIMVFATSFAEVHVGETLVYVNSLDCLAVAINQGSFSKAYNIQTGTNWRISIRKAPRIIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYA9</accession>
    <name>A0A173ZYA9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">resE7</name>
        <name evidence="8" type="ORF">ERS852471_00508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263609.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80158">
        <property type="protein sequence ID" value="CUN80158"/>
        <property type="gene ID" value="ERS852471_00508"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="406"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN80158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="657" mass="74448" checksum="06AC1DF4BAA5C80B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2P7</accession>
    <name>A0A174A2P7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81836">
        <property type="protein sequence ID" value="CUN81836"/>
        <property type="gene ID" value="ERS852471_00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017342" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN81836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="108" mass="10764" checksum="1FB67353E56C20BB" modified="2016-09-07" version="1">MKLRVIAATLLAATLLVGCGSKESGEKLTGKAEGFGGEVTVEVTVDGDKITAVTATGDSETQGIGSKAIEELPGKIVEANSADVEVVSGATVTSTAIIDAVKSALESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A383</accession>
    <name>A0A174A383_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase family oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydaD</name>
        <name evidence="3" type="ORF">ERS852471_00531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263649.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81955">
        <property type="protein sequence ID" value="CUN81955"/>
        <property type="gene ID" value="ERS852471_00531"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN81955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="31661" checksum="1751C108F94434CD" modified="2016-09-07" version="1">MEFPKSFPMQEQKHQPGFECEMNPRPIFDHPSYNKKGDTLNGKVAIITGGDSGIGRAVSIAYAKQGADIVIVYFNEHRDAEETKKLVEENGRRCTIISGDISEVEFCKNVVETTIKEYGKIDILVNNAAVQYEDKDFKDITDEQFDKTMKTNIYGTFYMTRESLKHMTSGSCIINTASVVAFKGNEKLVDYSMTKGAITALTRSLAIELAKAKKNIRVNEVAPGPIWTPLIPASFTKTEVASFGQNVAMGRAGQLVECAGAYVFLASENASYITGQTIHVNGGEIVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A3L5</accession>
    <name>A0A174A3L5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_1</name>
        <name evidence="5" type="ORF">ERS852471_00534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263653.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82136">
        <property type="protein sequence ID" value="CUN82136"/>
        <property type="gene ID" value="ERS852471_00534"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="28714" checksum="B42C77B08F14592A" modified="2016-09-07" version="1">MNREVLKVENIEKYYGKRGNITKAIDNISFAVENGEFIGVMGPSGSGKTTLLNCISTIDKVTSGHIKIADKDITKLNSKNIAKFRRERLGFIFQDFNLLDTLTAYENIALALTIQRLNHREIDERVKEVADKLNISDILNKYPYEISGGQKQRVASARAIITKPEIVLADEPTGALDSKSAKMLLESLEHLNKELGATIMMVTHDAFTASYASRILFIKDGKIFNELIRGNDSRKEFFNKIIEVVTLLGGDQRDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9L3</accession>
    <name>A0A174A9L3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">graR_3</name>
        <name evidence="9" type="ORF">ERS852471_00576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263729.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85311">
        <property type="protein sequence ID" value="CUN85311"/>
        <property type="gene ID" value="ERS852471_00576"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN85311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25980" checksum="71D85921D057CB60" modified="2016-09-07" version="1">MSKIMIIEDEVTIREELKVFLTRYGYEVLVPDDFSNIIDYVKSKNPNLILLDINLPIFDGYYICREIRKFSEVPIIIVTSRDSDVDELMSMNLGADDFITKPYNTQILLARIESILKRVYRNSTVQDVLEYGDMKLNLSNGTIVYNDKVIELTKNELKILSYLIKNRGKIVSRESLINYLWNCEMFIDDNTLSVNVTRIRKKLEEIGLSNIIETRRGLGYIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFU7</accession>
    <name>A0A174AFU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5-didehydrogluconate reductase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
            <ecNumber evidence="5">1.1.1.274</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ytbE</name>
        <name evidence="5" type="ORF">ERS852471_00603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EC" id="1.1.1.274" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263781.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87267">
        <property type="protein sequence ID" value="CUN87267"/>
        <property type="gene ID" value="ERS852471_00603"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050580">
        <property type="term" value="F:2,5-didehydrogluconate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="32148" checksum="01F97152AD1DA566" modified="2016-09-07" version="1">MNYVTLNNEIKMPSVGFGVFQIPEKEECVRVVKDAIDVGYRLIDTAQAYGNEEAVGEAIMESSIPREDLFITTKVWISNAGYEKAKKSIEESLNKMKLDYLDLVLIHQPLNDYYGTYRAMQDLYKEGKIKAIGVSNFYPDRLVDLSLFNEIVPAVNQIEVNPFHQQIEAQKVNEKYGVQLQAWAPFAEGRNGMFTNPELKAIGDKYNKSVAQVILRWLLQRGIVPLSKTVNKERMLQNIDIFNFELNEDDMNKISCLDKKESSFFNHQEASSVEMLASLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKV0</accession>
    <name>A0A174AKV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bmrR_1</name>
        <name evidence="2" type="ORF">ERS852471_00614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263802.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88068">
        <property type="protein sequence ID" value="CUN88068"/>
        <property type="gene ID" value="ERS852471_00614"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="32391" checksum="02ACA829E3391DFD" modified="2016-09-07" version="1">MNKNKQNYFTTGEFAKLVGVTKHTLFYYDKIGIFSPEIKLDNDYRYYSVFQIEVFYVISTLKELDMSLKDIKSYLDKRSPKELISLLEKEKNIIDEKINSLIKMKKVIEGKLSITKDIFNIDTNKISIERCEEELLVLTECCNVTNEKSLAKAIANHVKYCDKNEIYSPHSMGEMIHLENIKKGMYENYDYFYTRIYEGNENIKLYKKEAGLYLIAYHNKGFYTIDQSYERILKFVKDNNLELEGYFYEDVLLDELSVSGYDEYLIKISIKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQJ8</accession>
    <name>A0A174AQJ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphonate ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phnE_1</name>
        <name evidence="7" type="ORF">ERS852471_00658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263876.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90892">
        <property type="protein sequence ID" value="CUN90892"/>
        <property type="gene ID" value="ERS852471_00658"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1209768at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN90892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="28896" checksum="5F1A553F3443C4A6" modified="2016-09-07" version="1">MELTVKKQLEKQPNMWIHKALTVLFVVLVIVWASKGIAFSGIKGNGIEIAKNVVSGILHPDMEMLLDFKAGVPALLLETVCIALIGTLIGTILAIPLAFISASNLMPKWISKIGLFTIAALRTFPAFVYGLMFIRVTGPGAFAGVLTVSVISIGMISKLFIESIEDLDIKILESLDAAGCNTFDKIRYGILPQLFTDFISTAIYRFEINIKDASVLGLVGAGGIGAPLIFAMNAFNWDEVGAILCGLVILVLIVEILSTKIRTKLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATC1</accession>
    <name>A0A174ATC1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263882.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91159">
        <property type="protein sequence ID" value="CUN91159"/>
        <property type="gene ID" value="ERS852471_00661"/>
    </dbReference>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017924" evidence="1">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN91159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="36410" checksum="864A9ED61C015CA1" modified="2016-09-07" version="1">MKKLFALLTVLVLSMSMLIGCGSSEASNDELVVYFVPSRNPEEIQTATAPLSEMLKTELAGLGYEFNNVKIVVGTSFEAVGEALSSGTAQVGFIPGGTYVLYDDGVDVALTATRFGLSHDSENAADWNTAPTENTDEQVTYYRALVIAGPSEKGQELAAKINNGEELTLEDIQSATWGVSSNTTSPAGYIYPSLWLQDNFGISITDLQSKVALDNYTTAFTQLASGQIDVMVTYADARLDNVEKWTSDFGRTASIWEETNIIGVTDGIYNDTISVTKDASMTPELKEAIQQAFINIGNTEEGQEIISIYSHKGYQIADDANYDGERAAQELIKSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AU57</accession>
    <name>A0A174AU57_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydroxylamine reductase</fullName>
            <ecNumber evidence="7">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hybrid-cluster protein</fullName>
            <shortName evidence="7">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hcp_2</name>
        <name evidence="7" type="synonym">hcp</name>
        <name evidence="8" type="ORF">ERS852471_00666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="7">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263892.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91439">
        <property type="protein sequence ID" value="CUN91439"/>
        <property type="gene ID" value="ERS852471_00666"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337713at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="7">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN91439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="557" mass="62211" checksum="80FB422A5EB8AD4B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2E0</accession>
    <name>A0A174B2E0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263972.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95052">
        <property type="protein sequence ID" value="CUN95052"/>
        <property type="gene ID" value="ERS852471_00699"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2046686at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011397">
        <property type="entry name" value="YhfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10086">
        <property type="entry name" value="YhfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033101">
        <property type="entry name" value="UCP033101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="267" mass="29424" checksum="A278B773EBC0C82A" modified="2016-09-07" version="1">MNYLSLIICFIVNIIISIGIPLGILIYFAIKKKQFVKPFLVGALVFLVSQVVLRIPLLNGVVAKTDWFYNMSVLNPILYAVFLGLTAGIFEEVGRFIGFEIGLKKNRRWYDGIAFGLGHGGIEAILFAGISSIQNLYVIFSLNNGTFNSSLVGASEETVRGIFDSTSSIMVLYGGIERISAIIMHIGFTMLVLYGINKGKKALYLLWAILAHGVVDTTVVVVQQAGASIYMVELICIVFAIILLFGTIKVKGRFDNFKGVEENEKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9E7</accession>
    <name>A0A174B9E7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-oxoacid dehydrogenases acyltransferase (Catalytic domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264040.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97407">
        <property type="protein sequence ID" value="CUN97407"/>
        <property type="gene ID" value="ERS852471_00739"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374480at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN97407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="31548" checksum="37E1844F14359497" modified="2016-09-07" version="1">MRKDGILLKNIDPMRKLMPYLFKSRNGNIVYSPEEIEFDFSKDYLRNLNKSNPGLKIGTFELIITALIRTFAMYPYLNRFVANKKIYARNNFSLCFVVLKLIDGKYVESTAKVFFNKTESIFEVSKKINDAIELSRSNVVKDDDKLMSFFANLPSPILTFSAWAINNLIHIGVVPKKITDAIPLFSSVYISNLGSIGHNTLHHHLFEWGTTSIFLTMGKITKRNDKSFLNVVFSVDERIADGIYLVKALRYFSKLLKHPEALELPLYEIVEDDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BMF4</accession>
    <name>A0A174BMF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gmuD_1</name>
        <name evidence="3" type="ORF">ERS852471_00815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264191.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01409">
        <property type="protein sequence ID" value="CUO01409"/>
        <property type="gene ID" value="ERS852471_00815"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="462" mass="54154" checksum="C488ADF8A2C0E665" modified="2016-09-07" version="1">MAKYKFPENFTWGAATSGPQTEGWTDKKNFSIYDYWFQIEPEKFHNGVGPEINCDTYRKYKEDVELMKEIGLTSFRTSIQWTRLIKDFDTCEVDPVAVEFYNNYINEIIEAGIEPYINLFHFDMPIELQNRGGWENKEVIDLYVKYATKCFELFGDRVKKWCTFNEPIVPAEGGYLYKFMYPNIVDFKRAIQVGYNTIVAHSKAVEAFRKLNTGGEITIVLNLTPSYPRSQDEKDLEASRIADGIFNRSFLDPVVHGTFPSDLVELLKENNLMPEYTEEELEVIKNNPIDFLGVNYYQPRRVKAKETEVDVNAPIMPETFFDYYDMPGKRMNPYRGWEIAPQVMYDVAVNIKDNYNNIPWYISENGMGVEGEERFRDENGVINDDYRIDFVKEHLTYLHKGIQEGSNCFGYHLWTFIDCWSWANSFKNRYGFVALDLESGKRTVKKSGRWIKEVSETNEIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQ67</accession>
    <name>A0A174BQ67_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264205.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01778">
        <property type="protein sequence ID" value="CUO01778"/>
        <property type="gene ID" value="ERS852471_00823"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2044913at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="64" mass="7232" checksum="2B4A5D109AA51D52" modified="2016-09-07" version="1">MISVCPECSGINIDRLEKEFGKDNIDYRCIGECGGRDGIVLGYTKRTFIQAESDDEFIEIVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BR72</accession>
    <name>A0A174BR72_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system fructose subfamily transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">manX_1</name>
        <name evidence="4" type="ORF">ERS852471_00829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264217.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02138">
        <property type="protein sequence ID" value="CUO02138"/>
        <property type="gene ID" value="ERS852471_00829"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2008912at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO02138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="15509" checksum="9FDB46866F487AE0" modified="2016-09-07" version="1">MVGLIISGHGNFASGLRSSLKLIAGESINVEYVDFEETDSTETLKEKYYTSLKSLDNCDSILALADLAGGSPFKTLVEVKTEINKPMEVIGGTNLPMALEISMTKDMIDDLSLLSESALEVGRSGILKFEFIVHEDVECEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BTH2</accession>
    <name>A0A174BTH2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_1</name>
        <name evidence="5" type="ORF">ERS852471_00844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264238.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02938">
        <property type="protein sequence ID" value="CUO02938"/>
        <property type="gene ID" value="ERS852471_00844"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO02938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="331" mass="37563" checksum="F09B3DAC4CAD656A" modified="2016-09-07" version="1">MIKVESLTKEFRISKKYPGFKGAIKTFFSREYTEKLAVDSISFEIGEGEIVGYIGANGAGKSTTIKMMTGILTPTSGTVTVNGLVPYENREKNAKNIGVVFGQKTQLWWDLPISETFTLLKDIYEVSDEDFEERMNFLKELLGLEEFFLNPVRTLSLGQRMRADLAAALIHNPKIIYLDEPTIGLDVVVKENVRKAIKEINEKYGTTIILTTHDLNDIEELCSRIIIIDKGKKIYDGEIQGIKDKYGYLTTVEAQIKGDISINDLKFKEIVKDDDFNLDIKENKLAITFNKNKISSAEIISEVMKEAKVIDFIVKETSIEDIVKKMYRNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BX64</accession>
    <name>A0A174BX64_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264278.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04106">
        <property type="protein sequence ID" value="CUO04106"/>
        <property type="gene ID" value="ERS852471_00866"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1346169at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009343">
        <property type="entry name" value="DUF1002"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06207">
        <property type="entry name" value="DUF1002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018739" evidence="1">
        <location>
            <begin position="28"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO04106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="32136" checksum="F84FF0D16E8D1739" modified="2016-09-07" version="1">MKNKFLRKIALATLALVTLNFSIPALARKSNIQKGEILCFGADLNHTQEEALREYFNAPSDIDAVYVDNTVASRQLGYTDFTGGWYSSAYVKINENGTGINVKSNNLTLVTDGMLTNALITSGITDADIIASAPFPVTGESALAGIFEGAERITGIELKPEGKQVAQEEVEVTLDVADSIGSVEATALINEVKARVIEEAPKTTDEINKMVTDAASNLDITINEETKEKIVLLMNKINDLDIDYDSIKDSIKQNSSKLLEDLKSLGNEIKESGILERLWNWLKNFINKWTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C344</accession>
    <name>A0A174C344_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fumarate hydratase</fullName>
            <ecNumber evidence="8">4.2.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ttdA</name>
        <name evidence="8" type="ORF">ERS852471_00905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264372.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07544">
        <property type="protein sequence ID" value="CUO07544"/>
        <property type="gene ID" value="ERS852471_00905"/>
    </dbReference>
    <dbReference type="OrthoDB" id="972093at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008730">
        <property type="term" value="F:L(+)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO07544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="30854" checksum="4C73E9C297B8B0BD" modified="2016-09-07" version="1">MREVSVEKIIDTVKELCIESNYYLGDDIRNGLKDSIEKEEYPLANDVLKKIYLNADIARDNNMPICQDTGMACVFVELGQDVHITGGSLEDAINEGVRRGYEEGFLRKSVVKDPLNRVNTKDNTPAIIYYDIVKGDKVKITVAPKGFGSENMSRIAMLKPSDGIEGVKKFILETVENAGPNPCPPMVVGVGIGGTFDKAAYLAKKALLRPIDQSSEIEFYKELEEELIEEINKLGIGPQGFGGRTTALGINIEVYPTHIAGLPVAVNINCHATRHKEREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C356</accession>
    <name>A0A174C356_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Staphylococcal protein of uncharacterized function (DUF960)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264320.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06146">
        <property type="protein sequence ID" value="CUO06146"/>
        <property type="gene ID" value="ERS852471_00878"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065258at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009303">
        <property type="entry name" value="DUF960"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06124">
        <property type="entry name" value="DUF960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="103" mass="12366" checksum="129764480026FBAB" modified="2016-09-07" version="1">MFKKDNRYVTRKVNEEVDIRLQLIMWSMIDKLKDEGNVELDYLQVFRIRKEGNKIVISQSQEVPEYSCTYEIEIEDIQIEEEIKVYVIDSGEEFSTMLFPAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYH3</accession>
    <name>A0A174CYH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264594.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16845">
        <property type="protein sequence ID" value="CUO16845"/>
        <property type="gene ID" value="ERS852471_01061"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO16845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="22150" checksum="BAB81DACE3A32D66" modified="2016-09-07" version="1">MNTKNNKRFHDTEIRMEAAMLEIMKNTEFEKITVKKICEKAEVNRSTFYAHFIDIYDMIDKMEKELSKELLNQYSAYSELQVFSEESFIPFLRHIKKHKYFYKINLQTRKDFPLKQGFERLWEVIKNICIQNGITSDEEIMYYLIYFQAGFTMTLKHWVDTYCKEDEAKLAKIIRKCIPSTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZD8</accession>
    <name>A0A174CZD8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17160">
        <property type="protein sequence ID" value="CUO17160"/>
        <property type="gene ID" value="ERS852471_01066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019596" evidence="1">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="11974" checksum="235991254B0EC1C0" modified="2016-09-07" version="1">MIKIKKFIFTLLVALSIFTTTAYAEPKTKILKEGIYKQETFKSINADFRNISSTTMTVIVLVPGEYLRLYTDLRTNAVTSTKLIGKDDVIIVIGNGEVVFEYDTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5L9</accession>
    <name>A0A174D5L9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dosP</name>
        <name evidence="2" type="ORF">ERS852471_01139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.52" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264658.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20763">
        <property type="protein sequence ID" value="CUO20763"/>
        <property type="gene ID" value="ERS852471_01139"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="6"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="30935" checksum="6F97AF9951256662" modified="2016-09-07" version="1">MNNLSEIKIVQIIKTAIRNNSFTFVYQPIYNIETGIMEKIELLIRLKDNKFGIIQPNIFIPIAEEYNLLYRISDIVFEEACKAVKMLTDDNINFGKVCINVSLLHLKRCNFVKNTKAILDKYNISPNRICIEVIENSNVKDLEESKKVLNELSKIGIEIAIDDFGREYSNIDRIIEFNADCVKIDRCITSQLEDSSRARVILKHILNLSKELNIGIVVEGVENKSQLDMLKEYGYKLIQGFYLSEPVELEYLKNRDMTSLNLDKSNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DRH6</accession>
    <name>A0A174DRH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264769.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26869">
        <property type="protein sequence ID" value="CUO26869"/>
        <property type="gene ID" value="ERS852471_01241"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2231225at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="91" mass="10466" checksum="353A769F6E5FEEFF" modified="2016-09-07" version="1">MNSTFKSIIFTGIGLAIFFAISWLFISIVPYLLVGGLIIYIVVKFRKYFNNKNKGSNNQNGTETVYESSNVQADYYNENEKVIDVDYKEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS42</accession>
    <name>A0A174DS42_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aliphatic sulfonates import ATP-binding protein SsuB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmpC</name>
        <name evidence="5" type="ORF">ERS852471_01266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264815.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28047">
        <property type="protein sequence ID" value="CUO28047"/>
        <property type="gene ID" value="ERS852471_01266"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29010" checksum="597FC8A646DDE717" modified="2016-09-07" version="1">MSLLEINDINMNYHTSKGVTEAIKHLSFNIEEGEFVSIIGPSGCGKSTLLNIISGLLEPSSGKVIYNDPEVKNNLDKMGYMFQKDYLFPWLTVRENVLLGLKIKNILTDDNIKNADKLLKSYDLEKFKNHKPTQLSGGMRQRVALIRTLALNPSILLLDEPFSALDYQTRQKVTDDVYEIIKREGKTAIMVTHDLGEAIIMSKRVIVLTKRPATIKDDVKIIFSNKDATPFKKRQEPEFNRYFGELWKEIDGVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DUQ9</accession>
    <name>A0A174DUQ9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">murE1</name>
        <name evidence="1" type="synonym">murT</name>
        <name evidence="4" type="ORF">ERS852471_01260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264805.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27805">
        <property type="protein sequence ID" value="CUO27805"/>
        <property type="gene ID" value="ERS852471_01260"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="57"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="325"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO27805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="452" mass="50862" checksum="7F8ED2A520F3DF4B" modified="2016-09-07" version="1">MSKISIKSIISILATKFTIFLTKTILKGGTTFPGKVALKLDKDILTKVASGYNVILVTGTNGKTTTTSMIYNILKEKGYSVITNNTGANLYSGIVTTFIDNYKFSDKNHEKFAVIEVDEANVKFITEKITPNIITVTNLFRDQLDRYGEVYTTLTKILEGVTNVPTSKLILNGDESLLGKLDIKNTVVFYGFKTHINENKTIDINADAKFCKFCKTPYQYNFVTYNHLGDYYCTGCGYKRPELKYGVDEIIDLTSESSTVKINDTEIFLSQSGVYNIYNALCAYSITKELGVDDLTIKKSLESQSSSFGRQETINIDDKEVKIILVKNPAGYNQALDTLCLSKDPFSAAFILNDNYADGRDVSWIWDVNFEHLNDVELNEIYVSGLRSYDMAVRLKTAGLDSSKFSINEEYDALTESIKGSKNKKVYILATYTAMINYRKHLHSKGYIKNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E1T0</accession>
    <name>A0A174E1T0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase, M42 family</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ysdC_4</name>
        <name evidence="9" type="ORF">ERS852471_01351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264967.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31741">
        <property type="protein sequence ID" value="CUO31741"/>
        <property type="gene ID" value="ERS852471_01351"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO31741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="346" mass="37925" checksum="F37CA57919D66B0F" modified="2016-09-07" version="1">MSTNYSVNKDYLLSTAKKILEFNSPTGFCFEIMDKIEELVGEFGYKFERNNKGGGIITIEGSSDERVIGLSAHVDTLGAMVRSITKSGTLRFTLIGGPIVPTLDGEYCKIRTRDGKVYDGTFLSTSPAAHVYEDATTKKRDANNMEIRIDEVVKDKSDVEALGIAPGDFVFIDPKTTITESGFIKSRFIDDKGSVSALMALLEMFHRENITPKYKTKILISNYEEVGHGTSYIPSDITEMIAVDMGCIGEDLSCTEYDVSICAKDSGGPYDYNMVTDLVNLAKKNNISYAVDIYPMYGSDVGAALKAGNNIRGALIGPGVHASHGMERTHYTALENTIKLLTLYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2E9</accession>
    <name>A0A174E2E9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pepA</name>
        <name evidence="10" type="ORF">ERS852471_01349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264963.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31647">
        <property type="protein sequence ID" value="CUO31647"/>
        <property type="gene ID" value="ERS852471_01349"/>
    </dbReference>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="329"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO31647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="487" mass="53268" checksum="ACAA4203C57A3A71" modified="2016-09-07" version="1">MNISIKDVSFEFVDGLIIPTFEDGENNSAELDNILKISSFKGKEGEIFYITELKEKVKYKIFVGLGKKELLNGEVLRNAMAKAAKKAKELKIERIGIEFFRTDKICVGGRIKGITEGVRLALYSFDKYKEQKSQYNPEVYISGVPTEKLSKATERLEEVNNIVDGVIKARDLINEPANAMYPESLADEAIKIGAESGFEVQVFDEKECKDLEMKAFLSVGMGSSRKPRLIVMRYMGDNENSEVLGLVGKGLTYDSGGYSLKPSNSMVGMNGDMGGAAVVIGAMSAIAKNKLKKNVVAVVAACENLVSGEAYKPGDIIGSMAGKTIEVLNTDAEGRLTLIDAITYIIEKEGATKVIDLATLTGAAIVALGNYTTALMTNDEDFYDDFMRAADVTDEIFWRMPTFKHYRKQILGEKADLKNVDPNGAGTIVAGMFLKEFVQDKPWIHLDIAGTSDTKAPISEYIVKGGTGTPVRTLYYLAKGSCGCHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EM35</accession>
    <name>A0A174EM35_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein AppF</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">appF1</name>
        <name evidence="6" type="ORF">ERS852471_01458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265154.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37489">
        <property type="protein sequence ID" value="CUO37489"/>
        <property type="gene ID" value="ERS852471_01458"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO37489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="36235" checksum="C76DE9669A04C62B" modified="2016-09-07" version="1">MSSENILEVKNLKKHFPIKAGVFQHVVGHVKSVDGVSFEIKRGQTFGLVGESGCGKTTIGRTILRLTEPTEGEAILNGKDIFKMSKRDLQKIRPELQIIFQDPYSSLDPRMPVGEIIGEAVRAHGIVPKEKYREYILQIMDDCGLRPYHIDRYPHEFSGGQRQRICIARALALNPSLIIADEPVSALDVSIQAQIINLMKELQAKRGISYLFISHDLSVIKYISDVIGVMYLGNLVEMASKDELFDNPMHPYTKALLSAVPVPDPDVKMDRTILEGDLPSPANPPVGCKFNTRCPECMEICTKEAPELKIMKNGHKIACHLYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FI15</accession>
    <name>A0A174FI15_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble protein Ssp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sspC2</name>
        <name evidence="4" type="ORF">ERS852471_01668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117290.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49813">
        <property type="protein sequence ID" value="CUO49813"/>
        <property type="gene ID" value="ERS852471_01668"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2064087at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO49813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="6481" checksum="280D5BACBA6A5661" modified="2016-09-07" version="1">MSKALVPEAKNGLSAFKNEVANELGVPFTDYNGNLTSRQCGSVGGEMVKRMVEQYESGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNW6</accession>
    <name>A0A174FNW6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">atpA</name>
        <name evidence="14" type="ORF">ERS852471_01713</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265631.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51952">
        <property type="protein sequence ID" value="CUO51952"/>
        <property type="gene ID" value="ERS852471_01713"/>
    </dbReference>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="371"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO51952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="504" mass="55972" checksum="A2694570EA43E002" modified="2016-09-07" version="1">MNIKPEEITSIIKKEIVKYEKNIKTEDTGTIIQVGDDIARVYGLDDCMEGELLKFPNGVYGMALNLEHDNVGCVLLGPEEGIKEGDIVKRTNKISEVPVGEDMLGRVVNALGEPIDGRGPIYYEEFKPIEAPAPTIIDRTSVKEPLQTGIKAIDAMIPIGKGQRELIIGDRQTGKTAIAIDTIINQKGKDVICIYVAIGQKQSTVANIVNTLDKMDALDYSIIVAATASEGAPLQYLAPYAGCTIGEYFMNKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDIFYIHSRLLERAAKLSKEKGGGSLTALPIVETLAGDVTAYIPTNVISITDGQIFLESDLFNSGQRPAVNPGISVSRVGGNAQIKAMKQVSRNLRLELAQYRELASFSQFGSDLDTDSKERLEKGKRILEILKQKQYQPMKVEYQILILYVVSNNYLSDIELIDISKFEEQLLEFADTHYRDMLKDIKNKGVLTDEIKCDMEECISEFKKIFTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWQ6</accession>
    <name>A0A174FWQ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">prfA</name>
        <name evidence="8" type="ORF">ERS852471_01725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265651.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52505">
        <property type="protein sequence ID" value="CUO52505"/>
        <property type="gene ID" value="ERS852471_01725"/>
    </dbReference>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO52505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="361" mass="40693" checksum="D437DABBA623E6C4" modified="2016-09-07" version="1">MLLDKLAFTENKYEELSVKISDPSIMANQSEWRKLCKEHAELETLVTVYREYKKVVEDLAANKEMLSEESDKEMREMLSEEISMLSEKEAELENKIQIMLLPKDPNDDKNVFVEIRAGAGGDEAALFAANLFRMYTKYAESQRWSVELMSANETDIGGFKEVVFMIKGSGAYSKLKYESGVHRVQRVPDTESSGRIHTSTATVAVLPEVDDVDIEINDKDLRIDVFRASGNGGQCVNTTDSAVRITHIPTNTVVSCQDEKSQLKNKEKAMKILRARLYEVAEAERMAGIAEDRKSQVGTGDRSERIRTYNYPQGRVTDHRIGLTLYKLDSYLNGDIDEVINALITADQAEKMKAMGNTDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7V8</accession>
    <name>A0A174G7V8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation stage II, protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265800.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57228">
        <property type="protein sequence ID" value="CUO57228"/>
        <property type="gene ID" value="ERS852471_01801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040857at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014196">
        <property type="entry name" value="SpoIIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038973">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02831">
        <property type="entry name" value="spo_II_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO57228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="24159" checksum="9CAA6E2F263B8B7C" modified="2016-09-07" version="1">MNIINKAQHNYKENKIFYFMVFIFFCVGITLGTFMVKYMNYNDATDLTDYFLTFTKSIVSEQVNTKVLLLDVLKKNLILLTAIVLFGFTIFGAPLILLIDLIKGFTLGYTFSFLLTSFDGKGIWLAVASTLPQNIIYIPCFIALSIVFIQFSSMKLRDRFFNKGKVNTIVEKEIIFKVGVFLCVFIVGTIVETYLCPNLIKFILTNVYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHI1</accession>
    <name>A0A174GHI1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265942.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60598">
        <property type="protein sequence ID" value="CUO60598"/>
        <property type="gene ID" value="ERS852471_01878"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="59"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="34449" checksum="08A4D77B3B040353" modified="2016-09-07" version="1">MNYNFLLEKCTLCVRNCNVNRLNGQIGVCNSTASLKIARAKLHYWEEPCISGNNGSGTVFFSNCNLKCVFCQNHSISQEGNGLEISIERLSEIFLELQLQGAHNINLVTPTHYVPQIIEALKISKSKGLNIPILYNTNSFDSLETIKMLNGYIDVYLPDFKYFDDKYAIKYSKAQGYSKNTLEIIKEMVSQVGKPQFKDDIIQKGVIVRHLLLPGLLFDSKKVIDTLYNNFGDDIYISFMNQYTPLHNAKNFPEINKSINPKIYDSLVNYAISIGVKNGFIQEEGTSSESYVPSFKNEGVKSIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJ49</accession>
    <name>A0A174GJ49_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ssbB</name>
        <name evidence="4" type="ORF">ERS852471_01898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265973.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61407">
        <property type="protein sequence ID" value="CUO61407"/>
        <property type="gene ID" value="ERS852471_01898"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO61407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25690" checksum="67B03689BDF476E1" modified="2016-09-07" version="1">MDNLMLNNKIYLEGKIVSELEFSHEMYGEGFYTFYMEVPRLSDSVDLLNITISERLISNMNISVGNEIIVLGQLRSYNKFVDGSNKLILTVFARNIEPCIERSKNPNEIFLDGYICKEPVYRKTPFGREIADVLLAVNRAYNKSDYIPTIAWGRNSRFCQTLEVGDNIRVWGRLQSREYQKKVNDNEVIKKIAYEVSISKMERVTEETENNNTTTSPSEEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQQ2</accession>
    <name>A0A174GQQ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase EpsJ</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
            <ecNumber evidence="2">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epsJ2</name>
        <name evidence="2" type="ORF">ERS852471_01968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EC" id="2.4.1.212" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266104.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65032">
        <property type="protein sequence ID" value="CUO65032"/>
        <property type="gene ID" value="ERS852471_01968"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="338" mass="39299" checksum="C65B6A5EC1963394" modified="2016-09-07" version="1">MKPLVSVIVPVYNVEKYLNKCVDSIINQTLKDIEIILVNDGSTDNCPSIIDEYAKSDNRIIAIHKENGGQGSARNAGLDIARGEYIGFVDSDDWIDLNMYEELYESLLNNNADIAICSRQVYYEDYSIKYSIKVNNHVYKNIDKNIINYITSDMIYPNALLVTNKLYKAKLIKYKLINFENIKEIGSEDTLFNYKLLLDTKKIVSNNKVNYNQLFRNGSTMRTYNKGYLLRLSNLIDKIIEISDDYRVATIFYIHFMGRYSKLIIEFSKNKQKDLIYEYKDAMEKKTFIECTKNVLVNKDKILNKLGYRSNGIIIMKIKALLLLLRCYGIRAKLEQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRH4</accession>
    <name>A0A174GRH4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63877">
        <property type="protein sequence ID" value="CUO63877"/>
        <property type="gene ID" value="ERS852471_01939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031616">
        <property type="entry name" value="BsrE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16935">
        <property type="entry name" value="Hol_Tox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="33" mass="3759" checksum="96FD53A646444E26" modified="2016-09-07" version="1">MTNEALTILLQCGLFFIAFLELIIGLIDKFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS03</accession>
    <name>A0A174GS03_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apeB</name>
        <name evidence="11" type="ORF">ERS852471_01941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266054.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63958">
        <property type="protein sequence ID" value="CUO63958"/>
        <property type="gene ID" value="ERS852471_01941"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO63958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="431" mass="47201" checksum="2D7AE93492B3E6C4" modified="2016-09-07" version="1">MEKVLAKELIEFLYNSPSASHGVESVKAMLNVAGFTEIKEADKWNLKKGDKHYVVKNDSALIAFEVGNENIEEAGFRLIGAHTDVPGFRIKPNPQMISENTYVKLNTEVYGGPILSTWYDRPLGIAGKVAVKGSSPLKPEIRLVNINKPLLIIPSLAIHMNREVNNGYKYNAQVDTLPLLGLINDKLEREDYLMNTLAQELNVDKSDILNFELGLYEYEKGSLIGMNEELISSGRFDDLWMVFAGVKALIDSKEIDATKVMVCIDNEEIGSRTAQGAASSILNNLLERIILGLGKDTESYYRALSNSIMISADLSHAVHPNLGDKHDPTNRPVLGNGPVLKIAASGSYSTDSFNGAVFASVCEAANVPFQKFVNRSDVRGGSTIGPITSALLNIPVIDMGAPVLGMHSIRELAAVKDNYYTVKAFTEFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS81</accession>
    <name>A0A174GS81_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">artM_1</name>
        <name evidence="5" type="ORF">ERS852471_01937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266046.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63790">
        <property type="protein sequence ID" value="CUO63790"/>
        <property type="gene ID" value="ERS852471_01937"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO63790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="240" mass="26665" checksum="890F66F646B1E627" modified="2016-09-07" version="1">MIQIKNLHKSFNQNEVLKGIDDNIEKGEVVVIIGPSGSGKSTFLRCLNLLEVPTSGEIIFEGTNITDRKIDINKIREKMGMVFQQFNLFPHKTVLENLIIAPVMVKKISEEDAKKKAYDLLGKVGLVDKADAYPASLSGGQKQRIAIARALCMEPDVMLFDEPTSALDPEMVGEVLSVMKDLAKEGMTMVVVTHEMGFAREVGDRILFMDNGKIVEEGSPQEIFNNPKNPRTIDFLSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3P7</accession>
    <name>A0A174H3P7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix type 11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266266.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68871">
        <property type="protein sequence ID" value="CUO68871"/>
        <property type="gene ID" value="ERS852471_02053"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1518824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="25434" checksum="DC8EA75CF18DBF44" modified="2016-09-07" version="1">MRLLEILFYLLKCNSKTTIKELANRFNVSQKTIQRDLDKLSVLGIPIISYRGVNGGIELDKNYIIAKYVLTENDYRDLILSLYISEQVIDDLKKSDLIDKFKLINYDKCTEILDKLEDRFIVDLDDRNRVINNEVCKIIDKALDKKTYVKLEIKEKNIEVFPISYVLKKEGLYLYCYDDKYKLILIDNICNATDCERVFNGEIVKYKDNKDEIIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H410</accession>
    <name>A0A174H410_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266299.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69634">
        <property type="protein sequence ID" value="CUO69634"/>
        <property type="gene ID" value="ERS852471_02072"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1265821at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO69634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="284" mass="30688" checksum="63318AB4EC98289E" modified="2016-09-07" version="1">MRSIIKRVIVIVFYAVLAAVGVNMFLAPSNIFSGGVTGLSQLLSTVGLDFFNINISISAWVLIINLPLAVLSWLKLGKKFTIYTILAVVSSSFFMKIIPMVEITNNQILAAIFGGVLTGAGVGLCLREGFSTGGTDIIVLVVQKLTGKSVGQVGLLLNGAIVLAAGLIYGWEQSLYSLVAIYAMTQVMDMFFIQQHKLTVTIYTKKGDEMAKNLLSNNLRGVTIGKGFLGGYTKEELQSVITVISKHELLFIKKAVAEVDEDAFVNVQPTVDVIGKFLDKSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6I7</accession>
    <name>A0A174H6I7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amine oxidase</fullName>
            <ecNumber evidence="4">1.3.8.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">crtN_3</name>
        <name evidence="4" type="ORF">ERS852471_02042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.8.2" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266256.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68475">
        <property type="protein sequence ID" value="CUO68475"/>
        <property type="gene ID" value="ERS852471_02042"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102223">
        <property type="term" value="F:4,4'-diapophytoene desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="617" mass="70249" checksum="BC6ED4C8BBD98F17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6M6</accession>
    <name>A0A174H6M6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine synthase activation domain</fullName>
            <ecNumber evidence="3">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266340.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70632">
        <property type="protein sequence ID" value="CUO70632"/>
        <property type="gene ID" value="ERS852471_02098"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1410233at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017342">
        <property type="entry name" value="S-AdoMet-dep_Met_synth_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037984">
        <property type="entry name" value="Met_synth_TM0269_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="2">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="224" mass="25708" checksum="F4AC3B5F69B75783" modified="2016-09-07" version="1">MENNLKIDINEVLRYLGYRGQEITNELMEEVEEAIKESKCLLKVKYVCKEFKITKNNSDILLEGTNLRLKGKDIFNLLQNSDKCILMAATVGSDIERKIKFYSKINLTKALILDSCATAAIEEVCNNLQESIGREMLKGEENFTFRYSPGYGDLSLDIQKDFISILDCERKIGVKVSSNMLLFPRKSVTAILGITNKKQNRDRCKECSNFERCNYRKGDKRCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6T6</accession>
    <name>A0A174H6T6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermostable carboxypeptidase 2</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
            <ecNumber evidence="2">3.4.17.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yxeP_1</name>
        <name evidence="2" type="ORF">ERS852471_02054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EC" id="3.4.17.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266268.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68918">
        <property type="protein sequence ID" value="CUO68918"/>
        <property type="gene ID" value="ERS852471_02054"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="394" mass="43045" checksum="BE15E7DF167A8B36" modified="2016-09-07" version="1">MNDFIRQAQEIKNDLITYRRTMHNNPEVGAELPQTKAYVMNKLREFGYEPKEICESGIVATIEGNKPGKTFLLRADMDALPMVEATECDFKSTNGCMHSCGHDMHTAMLLGAARLLKQNQDKIEGTVKLAFQPDEEGFTGAKKMIKAGVLENPKVDAAMAMHVHSGTPSNVVLYGLGTSIAGCNRFRIVVNGRGCHGAMPETGVDPINIAAHIYISLQEIISREISATKPAVVTIGKFAGGDAPNIIPGEVIMEGTIRSLDKEVGEFIFNRINEIVTSTAKMFRGEAELIELSSVPPLTNDTDLANELGRYVKELIGEQAVVSFQGGGMGSEDFASYSYEVPSTYFMLGAGIKQENPLYGEPMHNEKVVFNEDILTTGAAMHAYCAIKWLQNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBQ4</accession>
    <name>A0A174HBQ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phoR_11</name>
        <name evidence="8" type="ORF">ERS852471_02090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70305">
        <property type="protein sequence ID" value="CUO70305"/>
        <property type="gene ID" value="ERS852471_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="840"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1059" mass="121003" checksum="04B144E78F6F49D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDH3</accession>
    <name>A0A174HDH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphotransferase system cellobiose-specific component IIB</fullName>
            <ecNumber evidence="6">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">licB_3</name>
        <name evidence="6" type="ORF">ERS852471_02143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266433.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72884">
        <property type="protein sequence ID" value="CUO72884"/>
        <property type="gene ID" value="ERS852471_02143"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846001at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023348" evidence="4">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO72884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="99" mass="10958" checksum="86DB383DA11719E3" modified="2016-09-07" version="1">MKKITLICAAGMSTSLLVTKMENVAKKNNLPVEITAIPQSKFVEYEDKTDILLLGPQVSFLYEDFKEKYEPKGIVVKVIDSADYGMMNGAKVLKAALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HES8</accession>
    <name>A0A174HES8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic sulfite reductase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asrA</name>
        <name evidence="6" type="ORF">ERS852471_02155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266456.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73354">
        <property type="protein sequence ID" value="CUO73354"/>
        <property type="gene ID" value="ERS852471_02155"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1092632at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014259">
        <property type="entry name" value="Sulphite_reductase_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02910">
        <property type="entry name" value="sulfite_red_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="335" mass="39504" checksum="A787C3E83DC097EB" modified="2016-09-07" version="1">MGYKFDIENFNGALKELSKEYKIYAPKVLEGKGRFSDTDIVRYEEVSRVEEIEFNKKSQFSYKEVLLPISQTLFFFTENEMKEADMEEKAPLIFLRSCDINSLRRIDDIYLRNGFEDPFYKKIREKAKFVLMGCEKSFENCFCVNMGTNTTDEYDMYIKVNGNEVYLDVKNEEFKDLMDKFNNESVDVTPDFVTENEVKVNIPENLTQEVMKSKMWDEYSERCIACGRCNFVCPTCTCFTMQDIFYKENEKSGERRRVWASCQVDGYTDMAGGHSFRNDKGQRMRFKALHKVYDYKKKWGYHMCVGCGRCDDICPEYISFSNCINKLEKAMDEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HF69</accession>
    <name>A0A174HF69_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemC_1</name>
        <name evidence="6" type="synonym">hemC</name>
        <name evidence="9" type="ORF">ERS852471_02160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266466.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73523">
        <property type="protein sequence ID" value="CUO73523"/>
        <property type="gene ID" value="ERS852471_02160"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="221"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO73523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="32618" checksum="84423F67253FF41C" modified="2016-09-07" version="1">MEIVIATRKSILAQVQADKVGKLLEEKRNLDYKKLLIVTEGDRRLDVSLNKIGGKGLFVKEIEYSLIRLEADCAVHSMKDVPYALSNEFEIIAIPEREDIRDCFISADGTHFNDLKEGATVGTSSIRRASFLKMMRPDLNIVPIRGNVQTRLEKMKKEEMDGIILAAAGLKRLGMEDIITDYFDPKVFLPAIGQGALGIECLKESKYRDEFKALDCKNSRITVEAERSFMTALNGDCHSLIGAYSEIIDDELYMIGAYEVDGEIIRKEIKGKIEDNKELGVKLAEKILNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGK6</accession>
    <name>A0A174HGK6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="2">3.6.3.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">potA_1</name>
        <name evidence="2" type="ORF">ERS852471_02174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.31" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74004">
        <property type="protein sequence ID" value="CUO74004"/>
        <property type="gene ID" value="ERS852471_02174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="129" mass="14837" checksum="FD4E87423AA06D5F" modified="2016-09-07" version="1">MEERVERKNDVLLKTKGLGYWYDNNKKILNNIDMEFEKGKFYSIVGSSGSGKTTLLSLIAGLDQVKEGDIFLGDNNIKNIGLDNYRNKHVSIIFQGYNLMNYMTALQNITSAMSIKKLKRKIIRNLLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJ25</accession>
    <name>A0A174HJ25_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic sulfite reductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">asrC</name>
        <name evidence="8" type="ORF">ERS852471_02157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266460.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73416">
        <property type="protein sequence ID" value="CUO73416"/>
        <property type="gene ID" value="ERS852471_02157"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014261">
        <property type="entry name" value="Sulphite_reductase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02912">
        <property type="entry name" value="sulfite_red_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO73416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="35741" checksum="E1EC503EC167E62F" modified="2016-09-07" version="1">MDINTKKLKKNAFRITKTRGVTASRVRVPGGHLKAEYLGLIQEIADKYGNGTVHITTRQGFEIPGISFKDMDAVNKMLQPIIEGLEINQENPGDGYNAAGTRNVSACIGNNVCPFANYNTSKFAKRIEKAIFPNDLHFKIALTGCHNDCIKARMHDFGILGMTEPQFDKNKCVSCGACVRACNKKSTGAIHAENYRPVRDHGKCIGCGECVINCPTGAWTRSKEKYYRLVIMGRTGKKNPRLAEDFIVWVDEDSIVKIITNTYKYVTEHIAKDAPGGKEHIGYIIDRTGFMEFKKYALEGVELSDKAVLKNNVYWSGVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HT49</accession>
    <name>A0A174HT49_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C_GCAxxG_C_C family probable redox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266590.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76240">
        <property type="protein sequence ID" value="CUO76240"/>
        <property type="gene ID" value="ERS852471_02238"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2083729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="141" mass="15944" checksum="7738769E359EADCC" modified="2016-09-07" version="1">MLVDRVIKYYDKEYDLNCAECMLVAANEEYDLNISKQTLMTMASFGGGMAIGSICGAITGSIATLGIMFTTERGHQSPQVRAMTVKFMNEYYKRMGSLDCLPLKDKYYEQGVPRCTKMMITAAEVLDEIVKEYSEHYAINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I517</accession>
    <name>A0A174I517_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage invertase/recombinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hin_2</name>
        <name evidence="4" type="ORF">ERS852471_02386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266838.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82264">
        <property type="protein sequence ID" value="CUO82264"/>
        <property type="gene ID" value="ERS852471_02386"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="159"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="539" mass="62105" checksum="87AE9A9F3C1BFD18" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBK4</accession>
    <name>A0A174IBK4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hlyIII</name>
        <name evidence="6" type="ORF">ERS852471_02416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266888.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83516">
        <property type="protein sequence ID" value="CUO83516"/>
        <property type="gene ID" value="ERS852471_02416"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1659567at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO83516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25723" checksum="B9E0D70ED6527407" modified="2016-09-07" version="1">MKQEKEKRKKQIKALNEPPKLTILEEVGNAVVHGIGAGLAIAGFILLLLKSDTGLKVMASCFYGISLFLLMIMSTLYHAFKSGSKVKRLWRRFDYCSIYLLIGGTFAPLYLVYWGNTLGIIIFSIQWALIVLGIVMISVFGPGRFKWLHFSLYFIIGWSGLVFLPDWFHNNRPLMWMILIGGVVYTVGMIPFTKDKKYSHFIWHFFVMIGAILHWIGIYYYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGI9</accession>
    <name>A0A174IGI9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pin/tram domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267011.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86354">
        <property type="protein sequence ID" value="CUO86354"/>
        <property type="gene ID" value="ERS852471_02479"/>
    </dbReference>
    <dbReference type="OrthoDB" id="940436at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO86354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="363" mass="39783" checksum="3D571B896956A8F2" modified="2016-09-07" version="1">MLKKLFRIIITTIGFILGYVVGDGLLNVFSDLEVKLLQSPISKIVFLFFVILVFGIILYFISPIIYKGLNKIIDTVERSVQKVSASELVYGTVGTIVALLIASLIGIPVVGIHPVAGPILLVLIELVAVIIGVKIFVEKKDDINSMIGNMKKSSSKEKKHKNNAKNISNVLDTSVIIDGRIFDICKTGFISGTLIIPSFVLDELRHISDSSDSLKRNRGRRGLDILNKIQKELEIETEIWEGDFPEIAEVDSKLLKLAQTLNGKVITNDYNLNKVAEVQGVPVLNINELANAVKPVVLPGEEMKVVVNKEGKESSQGVAYLDDGTMIVVEGGKKFIGEQLDVIVTSVLQTAAGRMIFAKQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174II25</accession>
    <name>A0A174II25_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplD</name>
        <name evidence="8" type="ORF">ERS852471_02494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267034.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86883">
        <property type="protein sequence ID" value="CUO86883"/>
        <property type="gene ID" value="ERS852471_02494"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO86883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="22801" checksum="5DC6FAA315ABF7F3" modified="2016-09-07" version="1">MPTVGLFNKEAKQVGDIQLNDKVFAVEVNEAAMHQVVVALLANKRQGTQSAKTRAEVRGGGIKPWRQKGTGRARQGSIRAPQWIKGGVVFAPKPRDYRMSIPKSMKRVAMVSALTSKVQNNEMVVLESLDFEAPKTKQVVEMLKAFEAKKTLIITAESNENVYKSARNIEGVAVLPVNNINVYDLLKYPTVMVTKDAVTKIEEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IJI6</accession>
    <name>A0A174IJI6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk</name>
        <name evidence="2" type="ORF">ERS852471_02462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266972.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85598">
        <property type="protein sequence ID" value="CUO85598"/>
        <property type="gene ID" value="ERS852471_02462"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO85598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="225" mass="26102" checksum="2BCF4182DCCEF04D" modified="2016-09-07" version="1">MSKGKLIIIESGSDASGKATQSKKLYERLINEGYNCMKITFPDYDSESSALVKMYLRGEFGSNPNDVSPYVASTFYAADRYASFKTKWEKFYNEGGIIISDRYTTSNMVHQAAKMDEEEKEKFLNWLSDLEFNLYAIPKPDQVIFLDVDPMVSQELMKNRLNKITGEEEKDIHESNEEYLIKSYNNSLKIAEKYNWNKVKCTEGKLLRTIDDIHEEIYKKVIEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J0U6</accession>
    <name>A0A174J0U6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hmrR</name>
        <name evidence="2" type="ORF">ERS852471_02575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267164.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90699">
        <property type="protein sequence ID" value="CUO90699"/>
        <property type="gene ID" value="ERS852471_02575"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="270" mass="31628" checksum="1A271E33AA85C36C" modified="2016-09-07" version="1">MAKYKIGQLSKTMGVSTHSIKHYEKFRLVHPHKDDTTNYRYYDLSQYARIIECRKFRNIGVPIKDISLLLNDSNNNEFNEILEDHISDLDSQIKTLLHQKKLAETLYNKSKYCDKYLNEWFIDIMPSIYFLKQSKNTDIIEDNHSFIDDINLIDYVPIVESILCINKDSFINNNITYSWGLGFTEENSYLINSTITKNNKFTRIESRKCFITYIKIQLPYIANGSLINTIKNILIKFPIKISSDILAFSIKKSNDNGVVYEYLKICIPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J2X2</accession>
    <name>A0A174J2X2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91928">
        <property type="protein sequence ID" value="CUO91928"/>
        <property type="gene ID" value="ERS852471_02607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025117">
        <property type="entry name" value="DUF4037"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13228">
        <property type="entry name" value="DUF4037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4037" evidence="1">
        <location>
            <begin position="114"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO91928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="267" mass="30724" checksum="A86B2B917EDC3AE1" modified="2016-09-07" version="1">MIVYQLVNEYKKFDEVLSITLTGSGASGKNDFFYDIDIEVILKAEIDANRRSKALKKFSDTIETISGKYGEKDIFILRNSTTEIDVSYYTLDTLKDNLFDVIDNCKASVGYTTCLWKVVSGAFIAYDKENTFKNLQKKYRVAYPQKLKLNIVDKNYYLLRDSISSYYNQIDKAIHTGDLISVSYKVCKFLDSYFDVVFAVNEMPHPGDKRLVSIINSRCKKIPRFLTEGVNTLIENSCKCNKEILKNMDDIVDDLKEFLHEEGIRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JG26</accession>
    <name>A0A174JG26_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267377.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96145">
        <property type="protein sequence ID" value="CUO96145"/>
        <property type="gene ID" value="ERS852471_02694"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="124" mass="13544" checksum="F53B638A138D38D8" modified="2016-09-07" version="1">MKVCFPINTNEGMNSIPYNHFGSAKMFIVVDSETKEVKTINNGNLDHEHGKCQPIKALCGEVVDAIVVSGIGQGAISKLKSMGIKVFKATDGTVEKNIELINKNELKEFDNSNICVHHDCGSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JKG4</accession>
    <name>A0A174JKG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267467.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98128">
        <property type="protein sequence ID" value="CUO98128"/>
        <property type="gene ID" value="ERS852471_02742"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2160564at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO98128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8316" checksum="9EDC0822C02B9774" modified="2016-09-07" version="1">MSKKTDWGKVLRETVNDIICAIKTPSAKPKQSKCPNPAARICIFVLIGITLLFSGIGIYSWIILIMLFIILYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JNW7</accession>
    <name>A0A174JNW7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mglB3</name>
        <name evidence="11" type="ORF">ERS852471_02754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO98865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267486.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98865">
        <property type="protein sequence ID" value="CUO98865"/>
        <property type="gene ID" value="ERS852471_02754"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025315" description="D-galactose-binding periplasmic protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="10">
        <location>
            <begin position="56"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO98865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="359" mass="38367" checksum="A000A624D6DC7FB7" modified="2016-09-07" version="1">MKKVKKLVALAVATLMMTASLVACGSSSTSESTGGNDTETSTEANADDTKSDVIKVGVCLYKFDDTYISTVRQSLEAIQKENSDKVEFEFFDGKGDQATQNDAIDTIISKGFDLLLVNLVDTGAGQTVINKIKDAGVPVVLFNREPAADAIKSYENAIFVGTNAQEAGVMQGKILTDLWNSEKDTLDKNGDGKIQYVMLQGEPDNPEAVARTKYSVSTLNDNGIETEEIAQQICNWQNDLAQTAMESWLSKDGDKIEAVIANNDGMALGAIAALQAEGLNKGDGEYIPVIGVDATEAAKDYIAKGYMQGSVLQDAPAMAEALYTIGMNLANGKTPTEGTSYTIDDTGVAVRIPYQPYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JP66</accession>
    <name>A0A174JP66_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavoprotein subunit FccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fccA2_2</name>
        <name evidence="6" type="ORF">ERS852471_02808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267585.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01584">
        <property type="protein sequence ID" value="CUP01584"/>
        <property type="gene ID" value="ERS852471_02808"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025316" evidence="4">
        <location>
            <begin position="30"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="644" mass="68379" checksum="5AD48F2CFBB9B3B8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JXE5</accession>
    <name>A0A174JXE5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbpA2</name>
        <name evidence="3" type="ORF">ERS852471_02824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267617.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02447">
        <property type="protein sequence ID" value="CUP02447"/>
        <property type="gene ID" value="ERS852471_02824"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP02447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="518" mass="56377" checksum="B22981BDFF4A038F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K240</accession>
    <name>A0A174K240_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">abrB</name>
        <name evidence="3" type="ORF">ERS852471_02849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032120359.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03505">
        <property type="protein sequence ID" value="CUP03505"/>
        <property type="gene ID" value="ERS852471_02849"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP03505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="9228" checksum="D316F0BEFB3910CA" modified="2016-09-07" version="1">MKSTGVVRRVDELGRIVIPIELRRTLDIAEKDALEIYVDGEQIILKKYEPACIFCGDARDVANYKGKNICKNCLNELKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K245</accession>
    <name>A0A174K245_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">carA</name>
        <name evidence="4" type="ORF">ERS852471_02877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04911">
        <property type="protein sequence ID" value="CUP04911"/>
        <property type="gene ID" value="ERS852471_02877"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP04911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="355" mass="39213" checksum="4435EFBC1FF135A7" modified="2016-09-07" version="1">MGGNINMKARLILENGMIFEGNAFGHLKDSVGEVVFTTGMTGYQEVLTDPSYYGQIVTMTYPLIGNYGINLEDNESETPNVKGFIVREKCNFPNNFRCEIGLEDYLKQNKIIGLEGIDTRALTKVLRNNGTMRGIISLEAETLQDVEGKIKAFSNKEAVSIVSTEKPYTIEGTGKHVAIMDFGIKTNIIRNFKKRGCKITVFPMNTRAEEILAVNPDLVFLSNGPGDPEDLGSVIENIKKIVGVKPIVGICLGHQLLGLTLGGKTTKLKFGHRGCNHPVKDLERNKVHITSQNHGYVVHELPEGVVATHININDGTIEGMKHTTLPIYSVQFHPEAAAGPKDSEYIFDRFMEYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K2M0</accession>
    <name>A0A174K2M0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267665.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03600">
        <property type="protein sequence ID" value="CUP03600"/>
        <property type="gene ID" value="ERS852471_02851"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1027015at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP03600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="28034" checksum="2CDF3237686FB61B" modified="2016-09-07" version="1">MDVNINIDESIDDLQLNGLMLIQKQSGFRFGVDAVLLSDFANVKKKHRVLDLCTGTGIVPFLVYGKYSPKEVWGVEIQEDMVEMANRSSQLNKTDDIVKFKCADLKDKKLVNELGRFDVVTVNPPYKLNNAGILNPNDKLAIARHEILCNLEDVIVSARRLLADNGRMFIVHRPERLADIFGLMRKYNIEPKRVKMIHPSAKKAPNIVLVEGQRDGGVFLKWDEPLYVYDENGNYSKEIDKIYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9I5</accession>
    <name>A0A174K9I5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-nitroimidazole antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267767.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05959">
        <property type="protein sequence ID" value="CUP05959"/>
        <property type="gene ID" value="ERS852471_02909"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP05959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="147" mass="17048" checksum="A5420E02CE5AD87D" modified="2016-09-07" version="1">MDICNYKNLSTKDIIAILNEEKMCYLATTDTTNISSVPMWYVFDYSDDNLIFYFISNNTSQKIDNIYYTGIAGITLLQHHRCRKVESYKTIIANGTTTVINDIKEKISIIEKFKNKYNCITNFSCIDTSNIKFFKVTVSEITGRYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KAS7</accession>
    <name>A0A174KAS7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF1407)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07177">
        <property type="protein sequence ID" value="CUP07177"/>
        <property type="gene ID" value="ERS852471_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010807">
        <property type="entry name" value="DUF1407"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029037">
        <property type="entry name" value="YfgJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07191">
        <property type="entry name" value="zinc-ribbons_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="49" mass="5484" checksum="693BDAB0F9C3EDB3" modified="2016-09-07" version="1">MTYYCPDCGKVIECIRGCGSTGYFCNECKKLISSKAVLTEPKTEVKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KCB4</accession>
    <name>A0A174KCB4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemC_2</name>
        <name evidence="6" type="synonym">hemC</name>
        <name evidence="9" type="ORF">ERS852471_02952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267846.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08076">
        <property type="protein sequence ID" value="CUP08076"/>
        <property type="gene ID" value="ERS852471_02952"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP08076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="32932" checksum="AEAB7AAEAAF7B965" modified="2016-09-07" version="1">MSKNKIIVGSRDSKLAVMQTELVMNQIRRYNPNLELELVTLKTTGDLILDKTLDKIGGKGLFVKELDQALIDGRIDIAIHSLKDMPMEVSEDLPIVALPTRGDARDVLVLPQGETLESLDRDKYLSNIGSSSNRRKLQLENLYGNVKITPVRGNIITRLAKLDRGEYSSLILAAAGLQRVGLENRISKYFSVEEMIPSAGQGILSIQARKDLDVSFLQGVNDPISMYCATAERSFVRVLNGGCSSPIAAHARVIGNEIKLVGLHYNEKTKEHIIDTIVGDVLKAEALGETLADKLRGEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEH6</accession>
    <name>A0A174KEH6_9CLOT</name>
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        <submittedName>
            <fullName evidence="8">Predicted exporters of the RND superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydgH_2</name>
        <name evidence="8" type="ORF">ERS852471_02943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267831.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07710">
        <property type="protein sequence ID" value="CUP07710"/>
        <property type="gene ID" value="ERS852471_02943"/>
    </dbReference>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="419"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP07710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="693" mass="76751" checksum="BAB339EFC213CFA7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KFY5</accession>
    <name>A0A174KFY5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08688">
        <property type="protein sequence ID" value="CUP08688"/>
        <property type="gene ID" value="ERS852471_02966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP08688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="68" mass="7848" checksum="B7FB867600D4CD72" modified="2016-09-07" version="1">MILTLLVVLIFLLIIIIKTLSSKTKLLEFELNIGIKCFKLYFKTNEKALHPTKNSCAFSQLKLFNCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KG29</accession>
    <name>A0A174KG29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267978.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11104">
        <property type="protein sequence ID" value="CUP11104"/>
        <property type="gene ID" value="ERS852471_03017"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1682250at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010374">
        <property type="entry name" value="DUF969"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06149">
        <property type="entry name" value="DUF969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="226" mass="24513" checksum="DA2E8319B7477541" modified="2016-09-07" version="1">MVLIGILIVIIGFALKFDSIAVIIISAIATGLAAHMDINEILIILGKTFVNQRLMTIFILTLPVIGISERYGLKEKAVQLIKQVKNLSTGKLLTLYCLLRQIGGAMSLRISGHPQFVRPLINPMAQGAAIGKYGEIDKKTEEKIKAAAASMDNYGNFYGQNLFLASSGVLLVANTLTELGYPTNGIDVAKASIVIAVVAFVFVLVQNMMLDKKLDKQYGINSKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KH59</accession>
    <name>A0A174KH59_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sbcC</name>
        <name evidence="3" type="ORF">ERS852471_02983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267914.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09806">
        <property type="protein sequence ID" value="CUP09806"/>
        <property type="gene ID" value="ERS852471_02983"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="710"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP09806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120543" checksum="4FCD91CB6AC2C072" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKF6</accession>
    <name>A0A174KKF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_12</name>
        <name evidence="6" type="ORF">ERS852471_03042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268029.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12473">
        <property type="protein sequence ID" value="CUP12473"/>
        <property type="gene ID" value="ERS852471_03042"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="41238" checksum="CDFF0516ABBF37FB" modified="2016-09-07" version="1">MREKVLEIRDLSISFTTSQGKVNAIRGVELDLYRGETLAIVGESGSGKSVTMKSVMGILSNNGEINSGTVNFTYYRDDEKIDVDLLKLSKKEMRDRINGKRVAMIFQDPMTSLNPTMTIGKQIMEGMIYHYKKSKKEAYDRAVELLKLVGINDAEKRMKNYPHQLSGGMRQRVVIAIALACNPDLLICDEPTTALDVTIQAKILELIKDIQRKMNLSVIYITHDLGVVAKVADYVAVMYAGKIVEKGKVDEIFYEPKHPYTWGLLSAMPDLDTDDNKLYTIPGSPPNLLMPVKGDAFAPRNMYALKIDYRLEPPMFKVSDTHYAATWLLHEKAPKIDMPEELKLKIDRMLKEADMYGREEAFAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZ33</accession>
    <name>A0A174KZ33_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268194.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17242">
        <property type="protein sequence ID" value="CUP17242"/>
        <property type="gene ID" value="ERS852471_03136"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2151679at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="43534" checksum="7B7F17F6F39DC460" modified="2016-09-07" version="1">MYLMPRLFGITMYCLIMLIFIIALMVSKKSKFILFIYAIVLAVMAYFYVPSYTADLYRIYNMMEYYVSMPFNEVLSVAVTSETPAAILYYYYIGKTGFPNLLPSITALIYYGNVFSIITRVKRKYKLNRNSVSIIVLFVMAFGQYVQVISGIRNMIAFSIIAKCIYEEFIENKKIISNLWKYVIAILFHQSATIVFIIRIIYEISTFNRTSSKDKAFKVSGIFIIIVLGIKYGQGLFRTVLSSATHYLTRNVYFYFWEFLLTALHILLIIVLMQRYKKLLKSEKNVLCLYRYVKIMIIINLIFIFEYNTFQRFSVLISMLMIPLLGKILKNIEENYKIPFNKNTRVIILLFSIIILLLACVRGNLSALKFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L4L0</accession>
    <name>A0A174L4L0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268200.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17397">
        <property type="protein sequence ID" value="CUP17397"/>
        <property type="gene ID" value="ERS852471_03139"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431599at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="350" mass="40813" checksum="FA3AA8885FC5713A" modified="2016-09-07" version="1">MKKNILILNQGITENYGDVAINNTITSFFKSKGFNIEYYPFWLEEYVFGKENILSKILMHAVWKIPFLMDFFNKNSIINKFKRLDYDAIIIGGGELLSGHRGFNSSLNIWSKFAEKRKIPIYLLGVSGDTNMPRYIFNRNKKSLNRFSGIFVRDSHSYDMLRNEYNVECKYSPDVVFAYNSICQNDNADLGIRKQLLCVPIDFNDSINKNMNIKDVEEYNEYLIKKILDNLKGNSKVLITCSVLDDVKFTKSFYNYAKNKLKEVEVEYVDYTCLDDYIELVKKSNCVISGRMHALILAFVNKCKIVPIPFKEKLICFNNEYSNENNILKIENKVIETFEELSQTIYTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6B9</accession>
    <name>A0A174L6B9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="12">R protein</shortName>
            <ecNumber evidence="12">3.1.21.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Type-1 restriction enzyme R protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hsdR_2</name>
        <name evidence="14" type="ORF">ERS852471_03156</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268228.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18391">
        <property type="protein sequence ID" value="CUP18391"/>
        <property type="gene ID" value="ERS852471_03156"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25184at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021810">
        <property type="entry name" value="T1RH-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11867">
        <property type="entry name" value="DUF3387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="270"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP18391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1004" mass="115619" checksum="F8786AB57B9661EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6R4</accession>
    <name>A0A174L6R4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_03141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268204.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17485">
        <property type="protein sequence ID" value="CUP17485"/>
        <property type="gene ID" value="ERS852471_03141"/>
    </dbReference>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP17485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="519" mass="59909" checksum="834A115EFBE31AA5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L9T9</accession>
    <name>A0A174L9T9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pduA_2</name>
        <name evidence="4" type="ORF">ERS852471_03179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19641">
        <property type="protein sequence ID" value="CUP19641"/>
        <property type="gene ID" value="ERS852471_03179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="3">
        <location>
            <begin position="131"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP19641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="23462" checksum="4927E8DF1BAA4231" modified="2016-09-07" version="1">MDEKNIEKSTEEAVEKKPKRGRKTSAKKDVKEPKKSKAKVEEAKVEDVKVEEVKVDASKVEEVNIEESKAVDAVNKDDIVQDGIDVKEAEVVEVVSKEDKAEDEIILEINKEEVFNKKDENLGGIKMGQQALGMLETRGLVAAIEGADAMVKAANVELVGTEKIGSGLVTVMVRGDVGAVKAAVEAGSEVASRLGEIVAVHVIPRPHSTVESILPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LD71</accession>
    <name>A0A174LD71_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsL</name>
        <name evidence="7" type="ORF">ERS852471_03225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117018.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22192">
        <property type="protein sequence ID" value="CUP22192"/>
        <property type="gene ID" value="ERS852471_03225"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP22192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="125" mass="13670" checksum="4E4E55E8E8AF27DE" modified="2016-09-07" version="1">MPTISQLVRKGRKTVVNKSTAPALNECPQRRGVCTVVKTTTPKKPNSALRKIARVRLTNGFEVTAYIGGVGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDCAGVANRMQGRSKYGAKRPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LGE2</accession>
    <name>A0A174LGE2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21786">
        <property type="protein sequence ID" value="CUP21786"/>
        <property type="gene ID" value="ERS852471_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP21786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="5904" checksum="5EE098458BA37722" modified="2016-09-07" version="1">MFKSLATGIVIGAAAAMVVLPQLDRKTQRAVRRTGKKMCCMAGDAYDNILNYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LMV2</accession>
    <name>A0A174LMV2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_7</name>
        <name evidence="7" type="ORF">ERS852471_03237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP22799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268374.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22799">
        <property type="protein sequence ID" value="CUP22799"/>
        <property type="gene ID" value="ERS852471_03237"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP22799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="32107" checksum="FBE6C2B41A9DD7D7" modified="2016-09-07" version="1">MAKVKEKKIKEPINWKKELKLAPAYLILFAWVAFTVIVIGWIFAASLSTSREIFKGDVLKFASGFHWENYVTAWKTQNVSVFFANSLFYATISCVGILLISAPAAYVLSRYTFLGNKTIKTSFVIGMSIPVIMIILPLFSIATKAHLTGNRWLLIILYICLNVPFTTTFLLNFFGSLSKSYEEAAAIDGCSPMKTFWVIMLPLAQPGVVTVTIFNFLAVWNEYFLALIFANSDSMKSVGVGLFSMVAALRAVGDYGSLFAAVIIVFLPTFLIYIFLSEKIIAGVTGGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEI4</accession>
    <name>A0A173XEI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urease accessory protein UreI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ureI_1</name>
        <name evidence="9" type="ORF">ERS852471_00010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AmiS/UreI family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262682.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49307">
        <property type="protein sequence ID" value="CUN49307"/>
        <property type="gene ID" value="ERS852471_00010"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2025504at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003211">
        <property type="entry name" value="AmiSUreI_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038523">
        <property type="entry name" value="AmiSUreI_transpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02293">
        <property type="entry name" value="AmiS_UreI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN49307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="170" mass="19114" checksum="8492C25815E79C30" modified="2016-09-07" version="1">MLGVVLLYVGVVLILNGIARLCKIDEKSMAVFNVFTGVLSFILNIVAVIQGNYFAAGTGLLFGFTYLFIAARCLFNLDGRLYGWYCLFVAINTIPLAFIDPTTLKFIDFTVGNIYWVIIWLLWGLLWLTGFIELVMKKDLGKFVGYLSVIDGIFTAWIPGFLLLINMFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEP6</accession>
    <name>A0A173XEP6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262704.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50251">
        <property type="protein sequence ID" value="CUN50251"/>
        <property type="gene ID" value="ERS852471_00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="65" mass="7429" checksum="D2FAEF2DC796833F" modified="2016-09-07" version="1">MRNEKNWIKAGILSVAIVVIFVTLFEMLGAYQEIGIVVATIIVFTMILCTYSIIDEIRELKHNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIN5</accession>
    <name>A0A173XIN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262714.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50495">
        <property type="protein sequence ID" value="CUN50495"/>
        <property type="gene ID" value="ERS852471_00032"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="17775" checksum="D8FEE3A23BE86613" modified="2016-09-07" version="1">MLIRRYETSDCKVLTELFYNTVHSINANDYTKEQLNVWATGSVDLEKWNQSLMSHFSVVAVEDGIIVGFGDIDKTGYLDRLYVHKDYQHQGIATAICDKLESIFDVEKITTYASITAKPFFEKRGYKVIKKQTVERKGVLLQNYVMEKSTNFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLU7</accession>
    <name>A0A173XLU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51797">
        <property type="protein sequence ID" value="CUN51797"/>
        <property type="gene ID" value="ERS852471_00049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN51797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="24573" checksum="2BDBEC5995D7E772" modified="2016-09-07" version="1">MIKAVIFDLDGLLIDSEIISYKIYKEILNQFGHDFSIEEYAQNFSGKTEVKNVTNLIDTYRLPLTIEIGLNNVLKIESKFLNQGVNLKTGAKELLAYLKDKGFKTAIASSSTKDRALTILKQHNIIEYFDEFVFGDEVEKGKPSPDIFLKACDKLSEKPEKCLVLEDSEAGIQSAYSASIPVICIPDMKVPNEYYLDMTKAVLHSLKEVISYLKKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XP43</accession>
    <name>A0A173XP43_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262786.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53030">
        <property type="protein sequence ID" value="CUN53030"/>
        <property type="gene ID" value="ERS852471_00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="593" mass="70526" checksum="A50F1BAA425819BB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XY34</accession>
    <name>A0A173XY34_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein HS6-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262934.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56901">
        <property type="protein sequence ID" value="CUN56901"/>
        <property type="gene ID" value="ERS852471_00157"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2066583at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="11924" checksum="8CCC39F4CF2F02C9" modified="2016-09-07" version="1">MNRFFNFLGLAKRSGNLIEGYSKCDEQRNKVNLYLVILSNDASDSTKRKFRNHCAEKQIPLIEDFSKEELGIAIGRAEIKILALKDKNMAEKLLALYQTEKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ69</accession>
    <name>A0A173XZ69_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 8">Histidine ammonia-lyase</fullName>
            <shortName evidence="6">Histidase</shortName>
            <ecNumber evidence="3 6 8">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">hutH</name>
        <name evidence="10" type="ORF">ERS852471_00135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 8">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 8">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6 8"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262897.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55758">
        <property type="protein sequence ID" value="CUN55758"/>
        <property type="gene ID" value="ERS852471_00135"/>
    </dbReference>
    <dbReference type="OrthoDB" id="715502at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="6">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN55758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="507" mass="55658" checksum="CD0413893CF47EA0" modified="2016-09-07" version="1">MEEIIINGKELTLQKLINISRFNRKVKIDDAAKDKVKKSRAIVEKIENEKKVVYGITTGFGKFANVTISTEDCKKLQRNLILSHACGAGRPLPTDVVRAIMVLRANALSIGYSGIRLSTLETLIKMVNENINPIIFEKGSLGASGDLAPLSHMVLPMIGEGEAEYKGEIMSGREAMIKADVNIVELTSKEGLALINGTQVMTAIGALTVYDAINLIKVSDIAAALTLEALRGIKDAFDIRAHKVRPHKGQLKTAENILNLTEGSTYITRQGELRVQDAYSLRCIPQVHGASKDAISYVEEKVLIEMNSVTDNPTILEDSDVISGGNFHGQPMALSFDFLGIALAELANISERRLERLINNQLNDLPSFLIENGGLNSGFMITQYAAASLVSENKVLAHPASVDSIPSSGNQEDHVSMGTIAARKSREILENVKRVIATEIMAACQAIDFREGLILGKGTKVAYDIVRQHVDFVKEDKIMYKDLEKITELITSEELLREVEKVIELKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2B3</accession>
    <name>A0A173Y2B3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ORF">ERS852471_00186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262992.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58322">
        <property type="protein sequence ID" value="CUN58322"/>
        <property type="gene ID" value="ERS852471_00186"/>
    </dbReference>
    <dbReference type="OrthoDB" id="776861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN58322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="24748" checksum="93C48F344364D0DC" modified="2016-09-07" version="1">MRISVAIDGPAGAGKSTIAKLVSKEFNLMYINTGAMYRAVSLMAKENNIAPSDIKRLMELIDTLEMHFENDDLILNGKNVQEKITMPEISSIVSNYASIPEVRQKLVNLQRNMSEKYNVLMDGRDIGTVVLKNAPFKFFLTATAEERAKRRFNELVSRGIEVNYDTLLSDIIKRDYIDSNREVDPLRMADDAIEIDSSNLSIEEVTEFICNYIKNKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCK5</accession>
    <name>A0A173YCK5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA 2-selenouridine synthase</fullName>
            <ecNumber evidence="3">2.9.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">selU</name>
        <name evidence="3" type="ORF">ERS852471_00238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.9.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61300">
        <property type="protein sequence ID" value="CUN61300"/>
        <property type="gene ID" value="ERS852471_00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043828">
        <property type="term" value="F:tRNA 2-selenouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017582">
        <property type="entry name" value="SelU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03167">
        <property type="entry name" value="tRNA_sel_U_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="42148" checksum="B31A9792E30A770E" modified="2016-09-07" version="1">MVTTNDFKNIVLKNISLIDVRAPIEFEKGAFQTSVNLPILTNEERHIIGICYKEKGNDEATKLGYEIVSGKTRENRISGWIDFIDKNPDSMIYCFRGGSRSTIAQKWISEIGKREIVKLEGGYKSFRNFLINSLEPNSIKAKPLILTGYTGSGKTILLNNLKNSIDLEGIANHRGSTFGHHVTIQPTQINFENNLAYEIIKHSNKEYKYIILEDESKNIGKSFIPNNLYRLFHSSDVIFLESSIEERVENILDDYVINGQKEFIAAYNDNELGVQLWYDDMLKSMERVKSKLGGDRLKIIIDEFNKAYSIQKATGSYDYNRVWIELFLNNYYDPMYKHSIEKDDRNIIFRGDKKAVLQYIKSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJ25</accession>
    <name>A0A173YJ25_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Band7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qmcA</name>
        <name evidence="2" type="ORF">ERS852471_00252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263135.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63934">
        <property type="protein sequence ID" value="CUN63934"/>
        <property type="gene ID" value="ERS852471_00252"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN63934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="314" mass="34769" checksum="0FF74B36CDA2772D" modified="2016-09-07" version="1">MIKLIVIGVLLLIVLLVLLSSIKVVNTGYLYVVERLGQFHRILEPGWHFMIPGVDFVRKKVSTKQQILDVPPQSVITKDNVKISVDNVIFYKMLNARDAVYNIEDFKSGIVYSATTNMRNIIGNMTLDEVLSGRDKINSDLLSIIDEVTDAYGIKILSVEIKNIIPPAEIQQAMEKQMKAERDKRAAILEAEGQRQSQIERAEGEKQAKILSAEAEKQANIRRAEGLRESQLLEAEGKAKAIEQIAIAEAEAIRKVNQAIIESGTNETVIALKQVEALKEMANNPANKLILPNETLSSLGSIAAIGEMLKGNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMZ2</accession>
    <name>A0A173YMZ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263167.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64973">
        <property type="protein sequence ID" value="CUN64973"/>
        <property type="gene ID" value="ERS852471_00272"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2012711at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10411" checksum="8486D554F51BEA6B" modified="2016-09-07" version="1">MEKELENIKLYDEDGNEINLKVIAFFDVVNPDNDEKCEYVIVEDEAYPDENPFALKVTKDEDGEEAFELIDNEVELAAVEEAYNTIFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQ72</accession>
    <name>A0A173YQ72_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoP_1</name>
        <name evidence="11" type="ORF">ERS852471_00290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263201.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65819">
        <property type="protein sequence ID" value="CUN65819"/>
        <property type="gene ID" value="ERS852471_00290"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN65819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="232" mass="26808" checksum="55FE0EFAE29A5D51" modified="2016-09-07" version="1">MANEKILVVDDEEHIVELIKYNLLSSGYDVITCNNGIDAVNLAINERPNLILLDLMIPGKDGYDVCKEIRTKSEVKNISIIMLTAKSEEFDKILGLELGADDYITKPFSVRELLARVKAVLRRVGAKEEQSDIMVFGDLSANFEKREIRIKGKKVDLTLKEFELLEMLIKNRGKILRREMLLDKIWGYEYIGETRTVDVHIRYLRKKIEDDDKNPKFIETIRGVGYRFNPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUF3</accession>
    <name>A0A173YUF3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263243.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67053">
        <property type="protein sequence ID" value="CUN67053"/>
        <property type="gene ID" value="ERS852471_00312"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1656873at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="25160" checksum="A87CA18D27B7C3CC" modified="2016-09-07" version="1">MPFGFYPDRTMLMLIPAILIALWAQSKVSSTYRKYKAIRTMNGYTGEQVARMMLDEAGLYDVPVVETGGELSDHYDPTRRIVRLSRDVFYGTSISAAGIAAHEIGHAIQHKEHYKPLVLRTSIATGVNFASQMSMILFVLGIFLSIPGLTTIGIIFFSASVIYQLVTLPVEFNASSRALKVLEGRGILLGNEVDGAKKVLGAAAMTYVAAALMSITQLLRLIALSNRNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z2D1</accession>
    <name>A0A173Z2D1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="6">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabG_1</name>
        <name evidence="7" type="ORF">ERS852471_00375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263354.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70632">
        <property type="protein sequence ID" value="CUN70632"/>
        <property type="gene ID" value="ERS852471_00375"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0753">Steroid metabolism</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="247" mass="26471" checksum="CAB3A4D6C7D04BBB" modified="2016-09-07" version="1">MLNNKNAVITGATRGIGREIAITLAKNGANIAINYRKENEDLSSLINELKELGVKVFTRKCDVSNGGEVDEFIKEAKESLGSIDILVNNAGITKDGLILRMKEEDFDSVIDVNLKGVFNATKAASGIMMKQRYGKIINISSVVGISGNVGQCNYAASKAGVIGFSKSIARELATRNVNVNVVAPGYIKTDMTKGLPEKVKESIIQSIPMKKIGEPKEVANLVLFLASDLSNYITGQVISVDGGMVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8F0</accession>
    <name>A0A173Z8F0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YgeV family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">zraR</name>
        <name evidence="6" type="ORF">ERS852471_00401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263399.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71970">
        <property type="protein sequence ID" value="CUN71970"/>
        <property type="gene ID" value="ERS852471_00401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="273"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN71970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="588" mass="66421" checksum="641B9D021B67F21D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZIV6</accession>
    <name>A0A173ZIV6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263539.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76161">
        <property type="protein sequence ID" value="CUN76161"/>
        <property type="gene ID" value="ERS852471_00481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="65" mass="7842" checksum="A80737C738445371" modified="2016-09-07" version="1">MYTLRLKKANNYKITLRNMTYEDVVKFQEIKNKRIKDIYKLAIFVMFGLMGLVTLMIHLYNLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZLF1</accession>
    <name>A0A173ZLF1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable D-serine dehydratase</fullName>
            <ecNumber evidence="3">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">D-serine deaminase</fullName>
            <shortName evidence="3">DSD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dsdA</name>
        <name evidence="5" type="ORF">ERS852471_00479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family. DsdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76048">
        <property type="protein sequence ID" value="CUN76048"/>
        <property type="gene ID" value="ERS852471_00479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01030">
        <property type="entry name" value="D_Ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011780">
        <property type="entry name" value="D_Ser_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF9">
        <property type="entry name" value="PTHR48078:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02035">
        <property type="entry name" value="D_Ser_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="91"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="462" mass="51838" checksum="0922842E9BC66615" modified="2016-09-07" version="1">MFLRNVLNFSRRGNVMILDRAMSDWIREFPIIKDLIELKETVFINPNKIKAEKAIEECRFSMDDIVDVAKRWERFAPYLAIAFPDTKALNGIIESPIVKISNMHKYLNEESGEEIQGDIYLKCDSKLPISGSIKARGGIYEVLHFAESLAIEKGMLKLEDDYSILAEDRFKELFSKYSIAVGSTGNLGLSIGIMAAKLGFKATVHMSADAKKWKKDMLRSKGVTVVEYKDDYSKAVSEGRKQAEADEYCYFVDDENSKTLFLGYSVAALRLKKQFEEIGIKVDKEHPLFVYLPCGVGGGPGGVAFGIKEVFGDNAHCFFAEPTHSPCMILGLSTGYHDKICVQDFNIDNKTDADGLAVGRASSFVGNIMEPFISGSYTITDERMYKYLYKTIDLENIRLEPSALAGMLGPYNIEISPKGKDYIKKEGIKNMKNATHIVWATGGNMVPEDIMEEYYNKGKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BC51</accession>
    <name>A0A174BC51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pleD_1</name>
        <name evidence="3" type="ORF">ERS852471_00737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97296">
        <property type="protein sequence ID" value="CUN97296"/>
        <property type="gene ID" value="ERS852471_00737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="162"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN97296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="34152" checksum="990EE897590BCD64" modified="2016-09-07" version="1">MSNICSGLAECEYLKLLFDKVRVINPLKNEIIHIFSKGVNESDGKCYSIWNKSNMCENCISMRAYNENKVFTKVEYNDNRVFAITAITMNKGREHYVIECIKDITDSMLINEVSCIAISEICEEIEKLNKLVITDELTECYNRRYINERFPLEIKESKRKNEKLTIVLMDIDNFKKINDKYGHQSGDYVLKEIGKIVKSNIRKEYDWVSRYGGEEFLIVFKNMDTENFIKSTEKIRKSIEEHKFIYNGVEIKLTASFGVAELSDKIDEMDMLIAEADKKLYKAKELGKNIVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDZ5</accession>
    <name>A0A174BDZ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble spore protein C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sspC1</name>
        <name evidence="4" type="ORF">ERS852471_00763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117680.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98723">
        <property type="protein sequence ID" value="CUN98723"/>
        <property type="gene ID" value="ERS852471_00763"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2064087at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN98723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="6548" checksum="A6BAF0B381A067CD" modified="2016-09-07" version="1">MAYNLVPEAKQGLAKFKSQVATEMGVPFTDYNGDLTSKQCGSVGGEMVKRMVEQYESGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BG88</accession>
    <name>A0A174BG88_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ORF">ERS852471_00764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264087.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98770">
        <property type="protein sequence ID" value="CUN98770"/>
        <property type="gene ID" value="ERS852471_00764"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="190"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN98770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="357" mass="39473" checksum="E950FF8B2E27B9D7" modified="2016-09-07" version="1">MSKYKIIMTGGGTAGHVTPNLALIPELKKRGFDIKYIGSIDGIEKEIIGDANIPYFPISSGKLRRYFDMKNFSDPFKVIKGIYQAKRILDKEKPDVVFSKGGFVAVPVVIAASMKKIPVVSHESDLTPGLANKLSAPFCNKLCVTFRESLAYVKDGKGVLTGTPIRNEILQGSKIRGKEICGFKDDKDILLVIGGSLGAKSINDEVRRDLSKILLDFNVIHICGKGNLDESLNSINGYKQFEYVKEDLPHLLQAADFIISRAGANVIFELLALKKPTLLIPLSKKTSRGDQILNANSFEKEGYSLVLDEDEMMEKHNLIDKLTDLKNNKNKLITSMQNSKVKNGVDEIISIILKSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGQ5</accession>
    <name>A0A174BGQ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264089.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98818">
        <property type="protein sequence ID" value="CUN98818"/>
        <property type="gene ID" value="ERS852471_00765"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1961680at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="15965" checksum="EB8B75330F3B4684" modified="2016-09-07" version="1">MKKVSIIYWSNGGNVELLANCIAEGIKGDIEINLKHVNDASEEDVITADAVAMGSPAMVEDEIEQLEMKPFIDKLSSIRFNNKPLVLFGSCGWRDDKFIHNWEAIMNDYGFETIGKVVCKESLTEKDVELAKTLGEEISKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIR3</accession>
    <name>A0A174BIR3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bcrC</name>
        <name evidence="3" type="ORF">ERS852471_00790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.27" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00079">
        <property type="protein sequence ID" value="CUO00079"/>
        <property type="gene ID" value="ERS852471_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="31313" checksum="EEF49915FC95EF3E" modified="2016-09-07" version="1">MELEIIRTIQSISNLFFDVLFQIFTMFGEELILISIITTIYWAYDKKFGEYIAYSSLTSLLFNNALKDIFKMKRPIGEEGIRTLRAETATGYSFPSGHSQGAASFYGSIAIYFKKRIIYILATIIIFLVGISRLYLGVHYPKDVLVGIALGLLISIISYKLFRTVNNRNLLYIITFICFIPALIFAQSPDFIKGMGTYLGFIIGVIVEKRYINFSVEGNLANKILRVVIGIAILLIIKSGLKVIFPNELIFHFIRYTIVTFVGIGVYPAIFKKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BT38</accession>
    <name>A0A174BT38_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264254.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03329">
        <property type="protein sequence ID" value="CUO03329"/>
        <property type="gene ID" value="ERS852471_00852"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1989297at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="35776" checksum="924928D688FC8245" modified="2016-09-07" version="1">MLKEINEKLIKLKEDIALKNVLEKKLETLNLQFDKDKKELNELEIKLKKEHKDVEKLEKLSFANIIATVMKNKSEKLEKEQQEYIMAKIKYDEFSSKLELLKENIESVKSRLETLKYCENEYKVLLNKKLELIKLYGDEEKKSKLAMIESEIDENLLEKKEIEEAISVGKDLLIAANSAKNSLESAKNWGIFDIAGGDMLSSIAKHNKINDAEVHFRRVSSLISRFNKELGDIKFEGLTFSSTTIAFDIFFDNIFTDFSVQSKINSSLDNVRRLICRVENILGTLNGKKVSINSRIANLRKNYDSIIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0U5</accession>
    <name>A0A174C0U5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO05949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264314.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05949">
        <property type="protein sequence ID" value="CUO05949"/>
        <property type="gene ID" value="ERS852471_00874"/>
    </dbReference>
    <dbReference type="OrthoDB" id="792870at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO05949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="412" mass="47574" checksum="89F2B0689057DA17" modified="2016-09-07" version="1">MARKNDINFDYNSEIKKCKTIDDVLGKNGLVQRLVKDVLENILEAEMDEHLGRDKYQRQSDIEPGERNYRNGYSQKNLRSSFGDVDLDIPRDRKSEFEPQIVKKYETVCNELDKKIISLYAKGMTTSDIQAEIEDLYGITISPSMVSKITDKVIATATEWQNRMLDKIYPIVYLDAMYFKVRSNGKIVNKAVYICLGYTMEGYKDILGLWVDEAEGAKFWLGICNDLKNRGVKEILIACMDGLKGLPQAIQTVFPSANIQTCIVHQIRNSIKYIASKDKKSFMKDLKEVYKAPTEELALAQLDKLKETWGNSYGMVIDSWYNNWNNLSTFFDFSPRIRKMIYTTNALEGFNRQVRKYTKSRSIFPTDESLNKCVYLATMEIMEKWTQPVPNWGATLAELTLFFTEELKDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7G1</accession>
    <name>A0A174C7G1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmuC_3</name>
        <name evidence="11" type="ORF">ERS852471_00910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264383.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07825">
        <property type="protein sequence ID" value="CUO07825"/>
        <property type="gene ID" value="ERS852471_00910"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="5"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO07825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="50195" checksum="5E636B371DA0E84E" modified="2016-09-07" version="1">MFSTLEKILMPVADKLGKNKILVAIRDGFLITTPLIIVGSIFLLIANFPIPGWGEMVAKFLGEGWQTWFTNVSRATFNVIALLSCMGTGYSYARELKGDKIQGAAIALVSFFIVMPTRIPYVGVDGAATISGLGFEYIGSNGLFLALMISLSSVYIFNWVYKKGWTIKMPEGVPPAVCDSFAALIPSAIVMTLFFLVRIGFEFTPYETAHNFIYQVLQTPLQGAGNTLAAQLVYVFACSGFWFFGINGPAVANTVFEPISKILTMENLEAFQAGLPLPNIFTSSFGNFFTNYGGGGSTLSLVIVMLLFCKSKRIKQLGKLAIVPGIFGINEPIIFGLPIVLNPVLIFPFIFVPMMNITLSYFVTKAGIIPYTTGVALPWTTPIGISGYLATGSIIASGWQFLLLFTGCLIYFPFIKMLDKQYLQEEDNAKNNNSGELSFDEVALEDISLDDISLDDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9S0</accession>
    <name>A0A174C9S0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dppB_1</name>
        <name evidence="8" type="ORF">ERS852471_00932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264427.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09009">
        <property type="protein sequence ID" value="CUO09009"/>
        <property type="gene ID" value="ERS852471_00932"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019015" evidence="6">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO09009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="35753" checksum="88A55E32F413CD01" modified="2016-09-07" version="1">MKRLATCLATMLASLLLIFFVIQAMPGDPVDTLTQEYMRSSQLSYEQAYNKAKLALNYDPDEPVVERFVSYVKGIATGNLGQSMSFKESVSKIVLGALPWTLLVCSISLLLSFTVGVILGIYVAWKRSKLLDGVLTGYQAVLGSIPDYIVAYLLVLLFSLTLGLFPSKGAYDSSVTPGFNLEFILNVLSHAALPILAYFLTTLAGWIMGMKANCMSVLGEDYINYAKARGISNKRIIFSYLGRNAMLPMVTSVAISFGMMFGGSPLIENLFVYPGVGYYLTTAISRRDYPLMQGMFLMIIVMVLLSGLFAEFLNTKLNPRLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CB81</accession>
    <name>A0A174CB81_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rubY</name>
        <name evidence="6" type="ORF">ERS852471_00969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264493.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10801">
        <property type="protein sequence ID" value="CUO10801"/>
        <property type="gene ID" value="ERS852471_00969"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="180" mass="21020" checksum="4B9A46B23B412C87" modified="2016-09-07" version="1">MDLKGSNTEKNLYRTFAGESRANTKYTLFAEKARQEGYQWVGEIFDKTAKNELAHARRVYGQFLKDVNSTCENLLDAIMGENEEYKNIYKKFEDEARREGFNDIADFFKELQEVEESHSERFKKLYDKLEDGTMFSGPKESKWCCMNCGYIHEGTEAPLICPLCKYPRAYFKPCCEIKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBT2</accession>
    <name>A0A174CBT2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA polymerase factor sigma-54</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sigL</name>
        <name evidence="11" type="ORF">ERS852471_00940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264443.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09400">
        <property type="protein sequence ID" value="CUO09400"/>
        <property type="gene ID" value="ERS852471_00940"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="10">
        <location>
            <begin position="95"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="9">
        <location>
            <begin position="295"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO09400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="457" mass="53119" checksum="E82E5A0DFF1832DD" modified="2016-09-07" version="1">MKLDFNLNLSQQQKLVMTQNMQLSINILQMSACELREFINKELEENPIIDSDFNLKKNTEIEQYKKMIESMEYDNSIYNSYSKGEYDEEGLSPLNFVSEKKTLKSYLYEQLHTNKEVKNLRIIIDYMIESLDSRGYLDETVENICNKFNISEEKCVQALEILQDLEPAGIGGRNLKESLLIQLKRKKKLDLNLENIINNYLDLVADNKFKDIAKYLNISQIEAQNYGDIIRELEPKPSRGYYTGDDVKFITPDAYIKKIDKEYTVIMNNDIVPQLSINGVYKNLLLHGSDKEVESYIKEKIGSAMFLIKSINNRENTLRIILEDIIKRQKEYLDKGKKYLKPMMLKDIAEDINMHESTVSRAIKDKYILTSYGTVKIKDLFTVGYSTKSSSDGKNVSAKNIKDIIKEIIDSEDKKKPFSDEMICTELSKKNLNISRRTVAKYREEMGIKSSSKRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIW4</accession>
    <name>A0A174CIW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rubrerythrin</fullName>
            <ecNumber evidence="1">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbr3B_2</name>
        <name evidence="1" type="ORF">ERS852471_01019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13461">
        <property type="protein sequence ID" value="CUO13461"/>
        <property type="gene ID" value="ERS852471_01019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="34" mass="3858" checksum="110D3DB074BB77B0" modified="2016-09-07" version="1">MANLDAIHDTVHEMAKDEARHGKAFEGLLNRYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYH2</accession>
    <name>A0A174CYH2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein cotJC</fullName>
            <ecNumber evidence="2">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydbD_2</name>
        <name evidence="2" type="ORF">ERS852471_01087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264611.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18203">
        <property type="protein sequence ID" value="CUO18203"/>
        <property type="gene ID" value="ERS852471_01087"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1420351at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="23582" checksum="300B653B4577E970" modified="2016-09-07" version="1">MWYYVKTLEYPINLKSKDLKMAKFLVSQYGGPDGELSAALRYLNQRFTMPTCKAKALLTDIGTEEMAHVEMIGTMVYQLMSNATLDELVEAGLGGHYTDHGRALFYTDATGNPWTATYIQAKDDVVADLYEDMAAEQKARATYEWLINLTDDQEIKEILRFLREREVVHFQRFGEALMNVQDHFSSNPNYCCEKRTIVTADDYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZ08</accession>
    <name>A0A174CZ08_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264617.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18741">
        <property type="protein sequence ID" value="CUO18741"/>
        <property type="gene ID" value="ERS852471_01097"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1778771at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025648">
        <property type="entry name" value="DUF4358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14270">
        <property type="entry name" value="DUF4358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="19623" checksum="22B8621176BA55F8" modified="2016-09-07" version="1">MHKHKKINLHKRNKYRNYYLIEIAIIIALFIGLYPMLGVKTADMAKIKSDLEKTINLDCVNVGDEKTLKNLYYINKNDIEDFISYAPKSNMEVEEILVLKTKEGTDISEIKSKINKRLEKQGESFKNYRPEKYNIIENAVLEEEGQYLIFIVSENASAIKKIIKDNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZS7</accession>
    <name>A0A174CZS7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264599.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17248">
        <property type="protein sequence ID" value="CUO17248"/>
        <property type="gene ID" value="ERS852471_01067"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085406at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO17248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="13904" checksum="06ABF6786D909B00" modified="2016-09-07" version="1">MSELKVFTKEMVTGGDTYEIAYAHSYPERHWSEDSLYFNDDEDGIKILSPYFDKVFPEYAYYGPQKVRIYQWNEIERLCREENNENISIEEFFEKVRSWINKGNKGEDYFWILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8E9</accession>
    <name>A0A174D8E9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-propeller domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264648.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20288">
        <property type="protein sequence ID" value="CUO20288"/>
        <property type="gene ID" value="ERS852471_01129"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019820" evidence="5">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO20288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="29537" checksum="8BFCB842FF6A0A00" modified="2016-09-07" version="1">MNRKLNFFIKFTFSLLIFSLLFSLNVFCSETFPDPTNLKYFNDYTNTIDYSTAKQIVSIGKELEDKTSAQAIIVVINSTNGAPIEDYANKLFRTWGIGKKTKDNGLLILLAINDKSWRIEVGRGLEGAIPDALTNRIMQTTAKPCFINGNYSEGLLNSYSIFSDYIASEYDVTLEKSLNITLPNEGTQSGEKEVKIAVSLFLILIFADIFLNRGRVSSSILHLLFWNNFFNGNGRGGPGGFGGGSSGGGGSSGGGGFGNFGGGSSNGGGSSGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DF04</accession>
    <name>A0A174DF04_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yocH_2</name>
        <name evidence="4" type="ORF">ERS852471_01178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22595">
        <property type="protein sequence ID" value="CUO22595"/>
        <property type="gene ID" value="ERS852471_01178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019966" evidence="2">
        <location>
            <begin position="27"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="3D" evidence="3">
        <location>
            <begin position="320"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO22595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="386" mass="42730" checksum="D6A36862C56E70F6" modified="2016-09-07" version="1">MNKELKLIASALALCVTFNVSFPVMAAPENTSIDQHKVKYQELNTEIKQINEKISSLDVEIEEINQNLEENNRKIEDTKIEIENTKNLLIQNEKEMDEAQNKLNIRVRSLYKSNLTSNIILFVLNSESFSDLFNRIHSVSKIISLDKELMKDIDEKKEKLEQTSESLKKNEDELNSLNEEISKDLAEVESKKSEQQSALNELNEQKNEVFAIIEANEKTLVEHPLSIINSSTSSISQIQDAVNTLEGLLPQLTSSYVIGLAQDGIYQGNVIIEEANTPPVAPPSLDEDGKATYQMESTAYTGGGITAIGLKPIHNPNGISTVAVDPNVIPLGSKVHVSGYGVAIASDTGGAIKGNIVDVYFNTHSECVSWGRRQVEVTILAYPGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS16</accession>
    <name>A0A174DS16_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205664.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26896">
        <property type="protein sequence ID" value="CUO26896"/>
        <property type="gene ID" value="ERS852471_01242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="55" mass="6241" checksum="D72B54BED7C7A25B" modified="2016-09-07" version="1">MAHKNNKNSKDNKKAGKKTKAELKEMKVETANEIGYSKESRKLGRDKPRKPEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSR5</accession>
    <name>A0A174DSR5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 3">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hprT</name>
        <name evidence="5" type="ORF">ERS852471_01276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264833.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28513">
        <property type="protein sequence ID" value="CUO28513"/>
        <property type="gene ID" value="ERS852471_01276"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="19785" checksum="F05E238E0EDDF058" modified="2016-09-07" version="1">MEDKKRNILFSEEQIKTRVRELGEQISKDYEGEELYVLPLLRGSFVFGADIFKSLDVKAKVGFMTTSSYGNDEVSTGKVKVVNDIPDNIEGLNVLIVDDIVDTGYTMEFAIDHVKKLGAKSVKTCVLLDKPSRRKVDLKPDYCCFEIEDLFVVGYGLDYHGFYRNVPYVFNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVE8</accession>
    <name>A0A174DVE8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein DUF92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264869.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29453">
        <property type="protein sequence ID" value="CUO29453"/>
        <property type="gene ID" value="ERS852471_01295"/>
    </dbReference>
    <dbReference type="OrthoDB" id="737126at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO29453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="28350" checksum="D918E88C0A1439F4" modified="2016-09-07" version="1">MEIIIGLISSTIIALVAYKKKSLNKSGMIAAIILGTAIFSLGGSIPFTLMLVFFISSSIISKIGKNKKKGLDKIHEKSDARDFVQVIANGGVAVICLFLFQKTKDIRFFIASAVSFAAANSDTWASEIGVLSKGKTISIITGKKIEKGVSGGISLLGTVSAFLGATVIGIAYTTIYILLVGYDKKSLIILFIIIILGFLGSIVDSILGITIQGQYIDDIEGNITEKKFNGRKENRLISGFRFINNDVVNILSNFIVTTLSILIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DY27</accession>
    <name>A0A174DY27_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264903.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30344">
        <property type="protein sequence ID" value="CUO30344"/>
        <property type="gene ID" value="ERS852471_01315"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909525at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="51" mass="6021" checksum="CDB1F14CC6FE4DAF" modified="2016-09-07" version="1">MTDKTLVCRDCGQEFVFTVGEQEFYKEKGFTNEPTRCAACRRAKKEQNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4S5</accession>
    <name>A0A174E4S5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264953.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31429">
        <property type="protein sequence ID" value="CUO31429"/>
        <property type="gene ID" value="ERS852471_01343"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2218876at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="89" mass="10041" checksum="6B457D3F407DA013" modified="2016-09-07" version="1">MTKHIFDKIALKNTENLSSHNFTNDYTLGISNNIDGLKINDDASNEEVLSDLNIEGVKGDREEERKLEHNKEGKNTNIADLPIFPNLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQ01</accession>
    <name>A0A174EQ01_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin like protease</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">vpr</name>
        <name evidence="9" type="ORF">ERS852471_01470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265174.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38050">
        <property type="protein sequence ID" value="CUO38050"/>
        <property type="gene ID" value="ERS852471_01470"/>
    </dbReference>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041365">
        <property type="entry name" value="CspB_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18425">
        <property type="entry name" value="CspB_prodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="CspB_prodomain" evidence="8">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="126"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="436"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="721"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO38050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1220" mass="133338" checksum="04CC359112D4A9ED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXG6</accession>
    <name>A0A174EXG6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="8">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">leuS</name>
        <name evidence="14" type="ORF">ERS852471_01510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265252.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41209">
        <property type="protein sequence ID" value="CUO41209"/>
        <property type="gene ID" value="ERS852471_01510"/>
    </dbReference>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="219"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="414"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="662"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="576"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO41209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="816" mass="92469" checksum="3CA9A7E36E4A06C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHZ8</accession>
    <name>A0A174FHZ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM-linked protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265511.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48558">
        <property type="protein sequence ID" value="CUO48558"/>
        <property type="gene ID" value="ERS852471_01644"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1514287at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO48558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="233" mass="26731" checksum="10C7D4E8EFCE2FEC" modified="2016-09-07" version="1">MRYVIKFTKGEDIKFIGHLDLMRTIQRIIRRSGLPIEYSKGFNPHMALSIAQPLSVGVYSDGEYLDLVLTKELKEEEVVNTLNEFAPPTIKFICAKGIEIIENVKRLPQTMALLDGARYTIKLKLNSEEGIAEAMDSMLNEKEFNIVKKTKKGEKETDIKPLIKELKYWVKDNELIINTLIATGSRENLSADLLVTYIKSKVDGINKDAFVNIRREEMYLLKKNKYVPLYKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKA4</accession>
    <name>A0A174FKA4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhgF</name>
        <name evidence="2" type="ORF">ERS852471_01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265587.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50694">
        <property type="protein sequence ID" value="CUO50694"/>
        <property type="gene ID" value="ERS852471_01687"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="648"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="721" mass="81137" checksum="AA5B3972371A4CF0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLK8</accession>
    <name>A0A174FLK8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-histidine dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.-</ecNumber>
            <ecNumber evidence="2">3.4.13.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pepD</name>
        <name evidence="2" type="ORF">ERS852471_01659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.13.-" evidence="2"/>
    <dbReference type="EC" id="3.4.13.18" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265540.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49370">
        <property type="protein sequence ID" value="CUO49370"/>
        <property type="gene ID" value="ERS852471_01659"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103046">
        <property type="term" value="F:alanylglutamate dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="211"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="483" mass="53258" checksum="EE541411CC903914" modified="2016-09-07" version="1">MKVLQNLEPKLVFDFFEKISDIPRGSGNEKAISDYLLNFGKELGLETIQDEALNIIIKKPASKGYENAPTVIIQGHMDMVCEKNNGTDHDFEKDPLKLRIVDDYIYATDTTLGADNGIAVAYGMALLADNSIPHPALEVLITTDEETGMSGAMAVSKDNLDGKLLINLDNEEEGELLVSCAGGVRTNSAIKIEWQDRADKATMSINISGLKGGHSGMDIIKERGNSNKILGRILKALKDELEFNIVKINGGSKNNAIPREAEVIISLDNSNVDKVTSIVNELADVFANELKAQDPGLKVVVNKVSVDESKEFNKDTTDKVINLLYLYPNGVNTRSTEIDGLVESSTNLGVLSTNEDYVEFDSAVRSSVPSLKKEIELRIKTITEIIGAEFSSKSDYPGWEYDPNSKMREICQKVYKDMTGKEAKIVAIHAGVECGLFNEKLGNLDMISFGPNLYDVHTPQEHMSITSVKNTWDYLLKILEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLL7</accession>
    <name>A0A174FLL7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ORF">ERS852470_02556</name>
        <name evidence="6" type="ORF">ERS852471_02517</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834855</strain>
            <strain evidence="6 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZV01000028">
        <property type="protein sequence ID" value="CUO51134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005212092.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="84024.ERS852471_02517"/>
    <dbReference type="EnsemblBacteria" id="CUO51134">
        <property type="protein sequence ID" value="CUO51134"/>
        <property type="gene ID" value="ERS852470_02556"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87832">
        <property type="protein sequence ID" value="CUO87832"/>
        <property type="gene ID" value="ERS852471_02517"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000095558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO51134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="72" mass="8179" checksum="11DA84B0F35518B4" modified="2016-09-07" version="1">MSKDDVIEMQGVVLEALPNAMFQVELESGHKILAHISGKLRMNFIRILPGDKVTIELSPYDLTRGRITWRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FN49</accession>
    <name>A0A174FN49_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation stage II protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265619.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51644">
        <property type="protein sequence ID" value="CUO51644"/>
        <property type="gene ID" value="ERS852471_01707"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014225">
        <property type="entry name" value="Spore_II_D_firmicutes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02870">
        <property type="entry name" value="spore_II_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="81"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO51644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="356" mass="40142" checksum="BA92654BCE7ADBB6" modified="2016-09-07" version="1">MNRRYKLNLNEGIKFLLFTTICIVVFMIIMPSILIKSEGINLDELSEVTKEIEAEITQPTTIEVKDIILNDSEMVSVYITSQNKIVDVPLEEYICGVISNEMPATFELEALKAQAVAARTYLASKKIKNCVKANGADICDSVHCQVYTSKEVRLELWQESDREKNWNKIVEAVESTKGQVMSYQNELVLYPQFFSTSSGMTENSVDLYWADIPYLKSVESTGEEIAPKFESEVSMTINEFINKFEESYPQSSLNASNIESSINVISKSEAGGVKEIQVAGETIRGQDFRFLYGLNSSNFTYEINDGNIIFKCKGYGHGVGMSQWGANVMAKEGKTYNEIIKHYYTGVEITNLRFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FP61</accession>
    <name>A0A174FP61_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">atpH</name>
        <name evidence="7" type="ORF">ERS852471_01714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265633.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51993">
        <property type="protein sequence ID" value="CUO51993"/>
        <property type="gene ID" value="ERS852471_01714"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO51993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="179" mass="21378" checksum="BCAF53F0527100A9" modified="2016-09-07" version="1">MYEFLDKRYAMALYEVADENGKVDEYIETLKLICELIDNYEEFYEFIKNPQVGTRNKKKAFINIFKNKIDEDLLSFLLILIEKDRILHLREKVNEMEKINLEKNNTLKGFVKTTIPLSDEQYNLLINNLEKKYNKKIILERIIDPNIIGSIYVKVEDEVIDGTIKFKMDKLRELMLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUP5</accession>
    <name>A0A174FUP5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">tdk</name>
        <name evidence="12" type="ORF">ERS852471_01727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265655.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52568">
        <property type="protein sequence ID" value="CUO52568"/>
        <property type="gene ID" value="ERS852471_01727"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1279539at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO52568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="22313" checksum="909703772BF28A6C" modified="2016-09-07" version="1">MSKLYFRYGAMNSGKSTNLMQVAHNYEERGMNVVLIKPATDKKGGDKLVSRLGVERKVDLVINSDMNIYDEVKKWNDDKYKINCILVDEVQFLKSYQIDQLFEIAVGLDIPVICYGLRTDFKMQGFEGSTRLLLLAHSIEEMKTICKCGRKAVLNGRKINGKFVFEGEQVAIDLVDNVEYESLCGHCYIKYKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1Z2</accession>
    <name>A0A174G1Z2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265727.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54365">
        <property type="protein sequence ID" value="CUO54365"/>
        <property type="gene ID" value="ERS852471_01764"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="140"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO54365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="39083" checksum="ED920656042BC67F" modified="2016-09-07" version="1">MKSKRANTVKKGRNYKHSNRLKKNKRKLNKLIRATIIIFIALVISTVALKSLNTMSLGTNKENNIDIKDNINIISDNKETNEEQNQLKEENINDNESNNKKVDSDEMVYLPLQEDINATDAREVQNRLTYWNYQREDNKKIAYLTFDDGPSEYVTDEILDVLKEKDVKATFFILGSMVDKNDYAKRALKRIVKEGHAIGNHGYCHRYDILYPGGVVNADVFMDDMKKSEDAMKKVLGENFSTKVIRFPGGHGSWDTSTIDSVLEQDGYSYIDWNTLNGDAEGQGLSPDQLLARLQETVTDLEGNNDVIVVLMHDTDAKESTAQYLGKAIDYLKSQGYEFKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G3U2</accession>
    <name>A0A174G3U2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_9</name>
        <name evidence="6" type="ORF">ERS852471_01775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265752.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55818">
        <property type="protein sequence ID" value="CUO55818"/>
        <property type="gene ID" value="ERS852471_01775"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO55818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="325" mass="36667" checksum="D2D084BF54511918" modified="2016-09-07" version="1">MAAVLEVENLCVDYITERGHIRAVDNVSFVIEEGESLGLAGESGCGKSTIAYSLMRLHRPPALITGGKIKMDGIDILSLSENQLQDFRWNKISMVFQSAMNCLNPVVTLENQFFELYKTHGITNNKKKARKMAEELLEIVGIPANRLGDYPHQFSGGMRQRAVIAMALALKPRLLILDEPTTALDTVVQREILQKIYELKEKFNFSILFITHDISLMMEFCDTVAIMYAGKIVEQASSKKILSNPQHPYSYGLKNSFPSLQGEIEYMEGIPGSPLNLSSIPKGCRFQDRCFKATKICFEEEPQRNSKDEEFFFCHNPLELVKEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEY3</accession>
    <name>A0A174GEY3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265923.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60127">
        <property type="protein sequence ID" value="CUO60127"/>
        <property type="gene ID" value="ERS852471_01866"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="363" mass="42083" checksum="E7846B8BE1E3E78E" modified="2016-09-07" version="1">MDYNAMIKEKLGKLLFLEINIKGFKENIGIPEYVTLKNNELYMPIDSKYISSNIQNEIKLKNIPIYCFIEGMFTAIGCDENLRFNDDYELILDYIKDTETCIKSLISKAIEKDELLEGYLLLKGYYRYSKDLDVYKKLLLVGEAIREKDSSFSEILMGDIEYAEERLLKITEGYLYKAMILKEKGEFEAARVALNEYFNKGGKETEEIKILNQDINNIADYEKAIALLENNPTKSIEILLSLCNEFDENPLIYYYLGIGFRKLENYDKAIYYLEESIRRESGILEVVVELGLNYACIGDYEKAIGLFKKAFEASRDVEICTNIIMCYLNIGDMENANLHLEIAKKLNPEDEIVKQIENIIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQY2</accession>
    <name>A0A174GQY2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1576)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266029.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63330">
        <property type="protein sequence ID" value="CUO63330"/>
        <property type="gene ID" value="ERS852471_01926"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1398052at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011470">
        <property type="entry name" value="DUF1576"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07613">
        <property type="entry name" value="DUF1576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="413" mass="45304" checksum="F799063BC787DA56" modified="2016-09-07" version="1">MDLRKNFYKPYKVLMLLYIFMILFGFIVNTPAEIFSGLKNILLTPDILITDYIQVGGIGGGIINAALTSLLCLLLLIFTNIVPNGSTIMALWVVTAFAFLGKNILNVWPIIFGVYLFSRYKKEKFSNYTLAALLGTSLSPIVTQLYYTDYLPKMPSLIIGIFLGILVGFILPPIASNSVKAHNGYNLYNVGFACGIIGTMLMSIFRLFNITFESRLEWYTGNQTSLLIFLFIIFIYLILVGLISSKDIKNNMINITKQSGRLVNDFYTSFGETVYINMGILGILSTLFILALGIDINGGSICGIFTIVGFGCFGKNVRNVFPVMIGATIAAMIHINPISSAGLTLAILFSTCLAPISGMFGWKYGILAGFIHVCIVCNTGYLHGALNLYNNGFAAGFTAMILVPLITAFKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTP9</accession>
    <name>A0A174GTP9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266116.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65351">
        <property type="protein sequence ID" value="CUO65351"/>
        <property type="gene ID" value="ERS852471_01976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="99" mass="11668" checksum="442B2327102982F9" modified="2016-09-07" version="1">MSLYKVTTTFALITDKPKLISKPLGILIKDDIIEVIKFYNNWAYFKYNDQDSYTHSYNLAELTKENYLKDYENNEDDEFCGLTPSMISKDISFDDNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU70</accession>
    <name>A0A174GU70_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsA</name>
        <name evidence="5" type="ORF">ERS852471_01999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266159.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66242">
        <property type="protein sequence ID" value="CUO66242"/>
        <property type="gene ID" value="ERS852471_01999"/>
    </dbReference>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="250"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO66242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="495" mass="55111" checksum="8FE2338CD3896231" modified="2016-09-07" version="1">MNNEVVLTMKNIDKKFLGVHALKSCSLTLRKGEVNALAGENGAGKSTLMKILTGIYQRDEGEITYNGKKIVFNNPREAQEAGIAIVHQELNLMNHLTAAQNIFIGRESEGFFLNDALLNKKTEELFKELKLNIKPTEIVGNLSVGKQQMIEIAKAISFKSNILILDEPTAALTEAETKELFRIMEDLKNKGVAMVYISHRMDEIFKITDRITVMRDGEFIKELKTKETEMSEIIKLMVGRNITSNKKEKSNVKDGAEVVLEVNNLNSKDVKDVSFNLKRGEILGFAGLMGAGRTETARLIFGADHRKSGVIKVNGKEINIKDTSDAVNAGIGYLSEDRKRYGLALGLSVSDNSVLANLENFSKGIIVDDKRIEDISQQFVEKIKTKTPSVKQLVKNLSGGNQQKVVIAKWLIKDADILIFDEPTRGIDVGAKSEIYNLMNELVEAGKSIIMISSELPEILRMSDRIAVMCEGKLTKILDIKEANQEVIMKYATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVC4</accession>
    <name>A0A174GVC4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kfoC_1</name>
        <name evidence="2" type="ORF">ERS852471_01967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266102.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64996">
        <property type="protein sequence ID" value="CUO64996"/>
        <property type="gene ID" value="ERS852471_01967"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="40048" checksum="00DB3250CCBFC103" modified="2016-09-07" version="1">MKVSVIIPVYNSEKYLDRCLNSLIKQSYSDIEVIIIDNGSKDNSINIIKEYSKNDNRIKMYTCNTSGASSARNLGLNNASGEYALFVDSDDYISEDYVEKMISYVKSKKTMVLCNNQEIWEDRIDERQLFENVDDEILSKEEVIKEIASGKAGLVCSKLIDLSIVKENNIQFDTNVKLSEDLLFFLEIAKYTEEFIHINESLYFYDRRNENSITRRYLENAWENQIYVLNKVEQILSQLNIKEEDKDLILCNKLKNCINFSIINELDDINFKNFKHKVRNIKEILNKKINVEKIEKKSYNSFQERVILSGIKAYSKSMWIIQLLFIFKVLIPIKYKIETIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVK2</accession>
    <name>A0A174GVK2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266110.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65247">
        <property type="protein sequence ID" value="CUO65247"/>
        <property type="gene ID" value="ERS852471_01973"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="39915" checksum="FF05DEFD62E200C2" modified="2016-09-07" version="1">MDRYLSNKIKNISLVLTFLVVILHAYNLEDSETVLSINFLIQNVISYGICTIAVPMFFMISGYLFFYKFNPTLQEWINKYKKRFKSLMIPFVIWCVGWMVVLYLVQLTPFGQTFFSNMIVSKFTLKQLFDYTFKYPIPFQLWYISDLIKLVIISPVIYYIIKLIGKIYAPIIIVLWFINIVKFPVTFFSLGCYLAIYYSKLDFKVKKSITIFIMIEFLLMCLIRSLIPVTMVNVSEIILNIIRIIGILSIWFGYDLLNKNESNIFRFSEYGIFVYFFHEPLQSFLYRIIFKFMSRSNLTEIILYIIIPIITISICIITGIILKRYSQKIYYILTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYW1</accession>
    <name>A0A174GYW1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65695">
        <property type="protein sequence ID" value="CUO65695"/>
        <property type="gene ID" value="ERS852471_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="35857" checksum="4EE3A7212311646E" modified="2016-09-07" version="1">MEENKMKYYYKVYGLNIESEIKIQELVILNDENKANIDVTIYIDKMPESINTAKNQGILEGFRKNEMWFYIKGIATYYIRNGQEIVVEPYRDIEDHYIKTYILGSAFGLLLIQKNIVAIHGGAVVFNDKAIICTGDTGAGKSTLTSALRLNGAKLVADDVSAIDIKDEIMVYPAYPQQKLCGDAVRKLGYDTGNFIRIDEGRDKYAIPSKSDFINKPIKLSAIFEIMVGDVEDVEIKELRGSEKMNTIMKNIYRGYVNQLAGLDREYLKKCLKVTKDINVYRMIRPKDKFIVNEQIEIIKEKLFKEYSKCISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZ07</accession>
    <name>A0A174GZ07_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nudG</name>
        <name evidence="2" type="ORF">ERS852471_02029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266230.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68002">
        <property type="protein sequence ID" value="CUO68002"/>
        <property type="gene ID" value="ERS852471_02029"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="124" mass="13909" checksum="31B602CBACFA460E" modified="2016-09-07" version="1">MIKVVAAILQNDDKILIAKKKEGKPLAGFYEFPGGKVEEGENPEDSLVRELMEEMSIKVTVKDYVGKSIYDYGNGKVIELLGYTAEIIEGDIVLTDHDEYRWVTLEEVCNYNIAPADIPLISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H279</accession>
    <name>A0A174H279_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lacZ_2</name>
        <name evidence="10" type="ORF">ERS852471_02013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266197.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67416">
        <property type="protein sequence ID" value="CUO67416"/>
        <property type="gene ID" value="ERS852471_02013"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245411at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="36"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="211"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="318"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="488" mass="56783" checksum="EBF14A4632491C81" modified="2016-09-07" version="1">MKDIISILNDPKVFEINRCKAHSDHYFEGYNTFKYSLNGNWKFSYSDNLDNVEKNFYKEDFNVDEWAEIKVPGHIQMQGYDRPQYVNTIYPWDGCENVPEGQAPKDFNPVGSYVKFLELTEDDLKDNNKIYLSFQGVESSFALYINGKFIGYSEDTFTPSEFEISEVLKVGLNKIAVQVYKWCSGSWLEDQDFWRFSGIFRDVFVYSVPKVHVYDLKVVAEVDDKYKNGILKSNLILNGNGEAIVQYELLDKDDEVIISGEKDNISIKNEITIDLEIKVDNPNLWSAEAPFLYTLKILLIADGEVIETVMQKVGFRRFELKNGIMQLNGERIVFNGVNRHEFNCNSGRVVSEEDMIWDLKTMKQNNINAVRTSHYPNNTRFYELCDEYGLYVIDEVNLESHGTWGLCTGPRKYNDKNILPNDKEEWVPLLLDRANSMYERDKNHPSILIWSCGNESYGGEDIYKMSKFLQGKDNTRLVHYEGVFQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3C8</accession>
    <name>A0A174H3C8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">6-phospho-alpha-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.122</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">malH</name>
        <name evidence="10" type="ORF">ERS852471_02016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.122" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266203.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67529">
        <property type="protein sequence ID" value="CUO67529"/>
        <property type="gene ID" value="ERS852471_02016"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050081">
        <property type="term" value="F:maltose-6'-phosphate glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="195"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="49964" checksum="2C8DB2EF9DC99205" modified="2016-09-07" version="1">MRKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRKIKLYDNDEERQNKVAKACEILIKEKDPSIEYVATTNPEEAYTDVDFCLAHIRVGKLEMREMDEKISLRHGVVGQETCGPGGIAYGMRSIGGVLENIDYMEKYSPDCWMLNYSNPASIVAEAVRRLRPDSRVINICDMPIGMEHNIAKIAGLESRKHMDIRYYGLNHFGWYTSIKDKEGNELLPKLVEHIKEYGFINGEEGMSTAKKDSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVVNHSNPEYTRANEVIDGREKEVFGACALIEKQGHSEGSGLQIGIHAEFIVDLATALAYNTQERMLLIVENNGAISNIQDDAMVEIPCIVGKNGYEPLSVGNIPTFQKGLIEQQLAVEKLVVDAWIEKSYHKLWQALMLSKTVPSATVAKELLDDFIVVNKEYWPELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6C4</accession>
    <name>A0A174H6C4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">amt_2</name>
        <name evidence="9" type="ORF">ERS852471_02092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266334.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70404">
        <property type="protein sequence ID" value="CUO70404"/>
        <property type="gene ID" value="ERS852471_02092"/>
    </dbReference>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO70404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="556" mass="59469" checksum="E4EAEEB24387A689" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H835</accession>
    <name>A0A174H835_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF1904)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266297.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69597">
        <property type="protein sequence ID" value="CUO69597"/>
        <property type="gene ID" value="ERS852471_02071"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1899588at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015017">
        <property type="entry name" value="DUF1904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08921">
        <property type="entry name" value="DUF1904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="107" mass="12557" checksum="FD899D12418A2D6B" modified="2016-09-07" version="1">MPMLRVKGIPQEEVMKESKELIDELVEIIECPRDYFTIELINNTFVMDGEVVAPPTIIEVAWFDRGQEVQDKVAKAITNHFKKDRECLDVVFQGLEHRNYYENGEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAH9</accession>
    <name>A0A174HAH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71873">
        <property type="protein sequence ID" value="CUO71873"/>
        <property type="gene ID" value="ERS852471_02121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
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        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="33086" checksum="160526DEF8364ADA" modified="2016-09-07" version="1">MIKLIVDSICDLPEEMYDKYDIDILPLRVMINDKEYLDRVTITIDQVYEEMRNGILPKTSQVSPAAIYETFDRHCEEGNDFIYLAFSSVLSGTCDLAKNISKEFKERYPERKIEVIDTKAGAIGIGVIAMQVIKLIENKESFENIINYIYEMTNHIEHVFILEDLNWLMKGGRINKVQAALGTMLDLKPMLDVNNGYLEVIKKVRGKKKSINTLLDIVEERINGFTDQVIGIGHADDEEAAEAVVKAIKERFGEDTKCVITKIGCVLGTHLGIGGVGVIFFNKKFDFYNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HG95</accession>
    <name>A0A174HG95_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_02171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266486.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73884">
        <property type="protein sequence ID" value="CUO73884"/>
        <property type="gene ID" value="ERS852471_02171"/>
    </dbReference>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO73884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="362" mass="39071" checksum="AC54BA836D35974F" modified="2016-09-07" version="1">MEKNRGLKSILAIVLGLLAGALLMLAMGFEPIKGYQFLFKGGLMNIERIGNTIATATPLILTGLSVAFAFRTGLFNIGTPGQMLFGGFCTIAVGLSFDLPTVVIVPLMVLAGILGGALWAVVPGLLKALFNVHEVVSSIMMNWIAYWTIYYTVPKYFKGEYLETESRMLPETATLRVKWLSDLFGGSYINLGIILALVAVFVVWFILNKTVLGYELKAVGFNRFGAEYAGMPVNRNIVISMMIAGALSGLAGVIQYMGNATVMQIGVMPSQGFDGIAVSLLGANTPIGVLFSALFFGILYVGKGFMNAAVKIPPELADTIIATIIYFAATSVVMDKVIKKFKNVKKDRLENKANSSERAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNJ2</accession>
    <name>A0A174HNJ2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rex</name>
        <name evidence="9" type="ORF">ERS852471_02245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266605.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76513">
        <property type="protein sequence ID" value="CUO76513"/>
        <property type="gene ID" value="ERS852471_02245"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872374at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="80"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="219" mass="24690" checksum="32F1354E48BBDF26" modified="2016-09-07" version="1">MERKKHVSMAVIKRLPKYHRYLQELMANDVDRISSKELGEKIGFTASQIRQDLNNFGDFGQQGYGYNVKDLYNQIGLILGLDREYKALIVGAGNIGQAIANYRFSKAGLNINAIFDANPKLLGMKIRDIEIQDIDELERYAQANPTDVGIICVPRINAQKVCDILVKCGIKGIWNFAPVDLKVPSDVIVENVHLSESLLTLIYLMHSEAAEHEQDQQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPC4</accession>
    <name>A0A174HPC4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system mannose/fructose/sorbose family transporter subunit IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">manZ_2</name>
        <name evidence="10" type="ORF">ERS852471_02253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266620.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76754">
        <property type="protein sequence ID" value="CUO76754"/>
        <property type="gene ID" value="ERS852471_02253"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1632067at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00828">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO76754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="273" mass="30038" checksum="888DD99DB18E39E2" modified="2016-09-07" version="1">MSEIKLTKQDRIHVFLRSNLHQGSWNFERMQALGYCYAMIPAIKRLYQGEDRKKALKRHLEFFNTQPFVTAPILGVNLAMEEQKANGADIDDGSINGLKVGLMGPLAGVGDPIFWGTLRPVTAALGASLALTGSLLGPLLFFLLFNVVRLGFRWIGIEYGYTKGTDIIKDMAGNKLQKLTEGASILGLFVIGALICKWTTVNIPFVLAEYTAQDGTNVVTTVQSVLDSLLPGLIPLLMTFGCMKLLKKKVNPLWIIFGLFAIGIIGYYFGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HW85</accession>
    <name>A0A174HW85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266651.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77310">
        <property type="protein sequence ID" value="CUO77310"/>
        <property type="gene ID" value="ERS852471_02269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1543557at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO77310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="15774" checksum="A148F4F2CFB38BA0" modified="2016-09-07" version="1">MYKCEVCGEIADIHHIVFRSQGGFDIEINYKYLCPEHHRGNDGPHHNRFIDLKYKLELQEKLYYCLPKDYYWPKELTEILGIHNGSLKRLLKDLKIHKEGYSKKDIIFKLMGNTLYSSEMIDELALDLLINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZJ4</accession>
    <name>A0A174HZJ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266763.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80324">
        <property type="protein sequence ID" value="CUO80324"/>
        <property type="gene ID" value="ERS852471_02347"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="247" mass="29273" checksum="076F3F3724F58B81" modified="2016-09-07" version="1">MGKRFEREYEIHYYDVDVKLQCKIESIVNYFTDIGTKQSEKLGVGIDYMTERNLAWVFCKYDVKINRYPKYGEKIRVATNALGFKKFYASRLYEIFDEEGNKIVEAVGIFLLIDINKRRAVRIPVEQYEFYGVSEEEECNINVSKLEKLKEEMYSKEFKVRYTDIDSNTHVNNVKYIEWALESIPVEILYKNNLVELSVVFEKECSYGDEIKSICEIKENDDQYIILHKIENAEGKELTTLISKWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1X2</accession>
    <name>A0A174I1X2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rnpA</name>
        <name evidence="6" type="ORF">ERS852471_02372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266812.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81203">
        <property type="protein sequence ID" value="CUO81203"/>
        <property type="gene ID" value="ERS852471_02372"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO81203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="13415" checksum="96ED07478345B9A5" modified="2016-09-07" version="1">MIYKIRKNAEFRLVYRRGKSYANNLLVLYVFNNRKNSLSDGDLYNKVGISVSKKVGNSVVRSRSKRLIYESYRLNCDNLKQGFDFVFVARTSIKDKKFKDVENAMISLFNKAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2A1</accession>
    <name>A0A174I2A1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase DbpA</fullName>
            <ecNumber evidence="12">3.6.1.-</ecNumber>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cshA_2</name>
        <name evidence="12" type="ORF">ERS852471_02319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="12"/>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266725.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79420">
        <property type="protein sequence ID" value="CUO79420"/>
        <property type="gene ID" value="ERS852471_02319"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="215"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO79420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="542" mass="60561" checksum="79850B4550720801" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2Y0</accession>
    <name>A0A174I2Y0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulators of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266737.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79670">
        <property type="protein sequence ID" value="CUO79670"/>
        <property type="gene ID" value="ERS852471_02325"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100576at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO79670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="23892" checksum="73F3D8852EB40594" modified="2016-09-07" version="1">MDSNVKWVNEEKILRTINSLEKNNMNGYIVNSKEELIDMIISLTNEGDKVSCGGSMSLVETGVMDHLRSGRYDFLDRAKEGLSAMDIDRIYRESFFADAYFSSTNAITEDGELYNVDGNGNRVAALLFGPKKVIIVAGVNKIVKNLDEAIKRNREIAAPANAKRLNKSTPCTKVGYCMDCKSAEKICREYTLIKSQKDKNRIHVIFLNDSIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I742</accession>
    <name>A0A174I742_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_2</name>
        <name evidence="2" type="ORF">ERS852471_02364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266796.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80889">
        <property type="protein sequence ID" value="CUO80889"/>
        <property type="gene ID" value="ERS852471_02364"/>
    </dbReference>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="253" mass="28200" checksum="AA8F0051202C3F59" modified="2016-09-07" version="1">MKKICIFNQKGGVGKTTTNINLCAYLAMEGYKVLTIDIDPQGNTTSGLGLDKKNLEFSMYDVLTANVSLSDVILKSELIQNLYIAPATMELAGAEVEVINRSDRETILLNEIAKVQDDFDFIFIDCPPSLGVLTINALTAVDSVLIPIQCEFYALEGVGQLINTIQLVKKSLNKSLDIEGVIMTMYDYRTNLSNEVYDEVKKFFNEKVFKTTISRNIRLAEAPSFGLPVMLYDEKCKGADAYKALTKEFLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGG1</accession>
    <name>A0A174IGG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267008.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86322">
        <property type="protein sequence ID" value="CUO86322"/>
        <property type="gene ID" value="ERS852471_02478"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1970248at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO86322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="132" mass="15079" checksum="07E973EBAEE8BB2B" modified="2016-09-07" version="1">MKDVIFDNFQNDVDDSLLRHKSILDILTKYSESSARVNRAVAKAVTNCGCIKINADKQSSPQDQDSLEDFYNSLNNHLDGELCETCRDVIEREMGNNMFYLTSLCNALNISLYDVLIKEDNKINTLGKFNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IMB0</accession>
    <name>A0A174IMB0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">cysS</name>
        <name evidence="14" type="ORF">ERS852471_02483</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267019.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86468">
        <property type="protein sequence ID" value="CUO86468"/>
        <property type="gene ID" value="ERS852471_02483"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="353"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="314"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO86468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="466" mass="53500" checksum="14CC0A219BAE347F" modified="2016-09-07" version="1">MKVFNSLTRKKEEFVPLEPGKVKMYVCGPTVYNFFHIGNGRTFIVFDTIRRYFEYRGYEVNYVQNFTDIDDKMINRANEEGTTVKEIGDKYICEYYKDADGLNIKRATVNPRATEYITDIVEFVKGLVDKGYAYAVDGDVYFRTKKFEAYGQLIGQNLDDLQAGARINVDERKEDPMDFAIWKARKPGEPAWESPWGLGRPGWHIECSCMAKKLLGDTIDIHAGGMDLTFPHHENEIAQSEALTGKKFANYWLHAAFLNVNNQKMSKSLNNFLTARDALKEYDADVIRFLMLSGHYRIQLNFSTELLDSAKASVERLYNAIGNLESLIDEVKLESMTDEEKKYLDSLDSYRQRYIEKMDDDFNTADAISVLFDLARDVNTNVTINSSKELCEKALELIRELGMPLGILQKTTKVSLEEEVEALIQARQDARKNRDFALADKIRDDLKARGIILEDTPQGVRWKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ISW6</accession>
    <name>A0A174ISW6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rpoA</name>
        <name evidence="13" type="ORF">ERS852471_02521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267067.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88019">
        <property type="protein sequence ID" value="CUO88019"/>
        <property type="gene ID" value="ERS852471_02521"/>
    </dbReference>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="247"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="315" mass="35016" checksum="993736500714472F" modified="2016-09-07" version="1">MLEIEKPIIECIESNEDGTYGKYVVEPLERGYGITLGNAMRRILLSSLPGVATTSVKIDGVLHEFSTVQGVKEDVTELILNIKSLALTMEGEGPKTIYIDAQGPGVVTGADIKTDGDVEVVNKDLHIATLDDNGKLYMELTVNRGRGYVTQNKNKSDELPLSAIAVDSIYTPVKRVNFTVENTRVGQITDYDKLTLEIWTNGTIKIDEAISLSAKILIEHFKLFMSLGVATNDVEIMIEKEEDKKEKVLEMTVEELDLSVRSYNCLKRAGINTVQELANKSMDDMMKVRNLGKKSLEEVERKLKELGLSLKLSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IWQ4</accession>
    <name>A0A174IWQ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmrB</name>
        <name evidence="1" type="ORF">ERS852471_02557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267129.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90027">
        <property type="protein sequence ID" value="CUO90027"/>
        <property type="gene ID" value="ERS852471_02557"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO90027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="166" mass="19357" checksum="BE2C1CE40D0DECD7" modified="2016-09-07" version="1">MKKLIIINGVMGVGKTTVSKKLYKELENSFWLDGDNCWAMNPFIVNDENKEMVLNNIGFILNSYLSNSTSKYVVFNWVIQSDDIMNEVLKRINTENIEIYKITLMCTKEELIKRIENDVKLGLRDSKNIERSLERYDMYKAMDTIKLDTTGKSIDEIIKEIVELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IZ62</accession>
    <name>A0A174IZ62_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensory transduction protein kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
            <ecNumber evidence="6">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yycG_5</name>
        <name evidence="6" type="ORF">ERS852471_02561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EC" id="2.7.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267137.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90150">
        <property type="protein sequence ID" value="CUO90150"/>
        <property type="gene ID" value="ERS852471_02561"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="148"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO90150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="366" mass="42792" checksum="59575CC4929B4465" modified="2016-09-07" version="1">MDIRLTQIKKDKILIRRSLKISKFIFNIIFILISIFILSYIKDNRLLVLSIILLVHVNINLFIRILFNTLRVGLTWRNIEEFIEGIELGKVSIENIQSKLIGDEDYRYFLGKQYGKVAEEIKNILDRVVKSIDNINRNEKMNIELVNNVTNKLDKPLESILENIEKLKEDKNDEEAIYNLKYRSNNIKLLIDELFEAAKVSSGDINIYTEKIEISSLLKQALIEYKDKIDSSRLVYKISIPKEKIYIKCNGEKMWRVFDILIQNTLKHSLDGSRVYVDLFTKDNRAYITIRNVSKEELNIEPDDLVNIINKNNEEDRSGLALEIAKNLVLLQSGDFDLDIKADLFSVIISFEIYKEESENDDKQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J1P7</accession>
    <name>A0A174J1P7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">engB</name>
        <name evidence="10" type="ORF">ERS852471_02643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267281.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93624">
        <property type="protein sequence ID" value="CUO93624"/>
        <property type="gene ID" value="ERS852471_02643"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO93624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="196" mass="22471" checksum="E7FCDD891210208E" modified="2016-09-07" version="1">MIIKTSEFITSAVKRNQYPVDVRPEVAFVGRSNVGKSSIINALTNRRKLAKVSQTPGKTRLINFFLINDEMYLVDLPGYGYAKVSKKEKESWGKTIETYLMEREQLKKVVLLVDSRHKPTADDILMHEWIKHFGYKVIVIATKSDKLSNNEIGKSKKLIKETLKLGPEDEFYLFSSVKKNGKEELIDNIFGDLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6T7</accession>
    <name>A0A174J6T7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lonA</name>
        <name evidence="5" type="synonym">lon</name>
        <name evidence="13" type="ORF">ERS852471_02642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267279.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93597">
        <property type="protein sequence ID" value="CUO93597"/>
        <property type="gene ID" value="ERS852471_02642"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="588"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO93597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="775" mass="86954" checksum="29612DC6EB294BEE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JA74</accession>
    <name>A0A174JA74_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative [Fe] hydrogenase, electron-transfer subunit</fullName>
            <ecNumber evidence="8">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nqo1</name>
        <name evidence="8" type="ORF">ERS852471_02664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267321.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94518">
        <property type="protein sequence ID" value="CUO94518"/>
        <property type="gene ID" value="ERS852471_02664"/>
    </dbReference>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO94518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="626" mass="68577" checksum="0D712ED2D3571D4A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCT1</accession>
    <name>A0A174JCT1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation stage V, protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267373.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96056">
        <property type="protein sequence ID" value="CUO96056"/>
        <property type="gene ID" value="ERS852471_02692"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1965283at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014204">
        <property type="entry name" value="Spore_V_AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02839">
        <property type="entry name" value="spore_V_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="118" mass="11969" checksum="E29B867EF8717B75" modified="2016-09-07" version="1">MDYISAFVVGGLICVIAQILMDTTKLTPARILVAFVTIGAILGGFGLYDKLIEIGGAGATIPLPSFGNSLAKAAIEGVEKDGLLGAFTGGITGAAGGITAAIFFGYLMAVIFNPKTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JFN1</accession>
    <name>A0A174JFN1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigF</name>
        <name evidence="9" type="ORF">ERS852471_02689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO95930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267370.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95930">
        <property type="protein sequence ID" value="CUO95930"/>
        <property type="gene ID" value="ERS852471_02689"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014236">
        <property type="entry name" value="RNA_pol_sigma-F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02885">
        <property type="entry name" value="spore_sigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO95930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="252" mass="28740" checksum="33C202B844F5EF75" modified="2016-09-07" version="1">MKNGNVRKEDFNYNDNSQLILLAKDGDKDAMNILIEMNLPLVSSISKKFLNRGYDYEDIFQIGSIGLVKAIKNFDNKYNVKFSTYAVPMIIGEIKRFIRDDGMIKVSRNVKSLARKIHFDREILTKKLGREPSVDELSEYAGIDKEDIVFAMESASGLSYLYDTIHQDDGSPVLLIDKLSENGEEDSGMINKIALKEALRGLDDKSRQIIMLRYFKDKTQVQVAKLLGISQVQVSRIEKKVLMQMKSKLEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JFX7</accession>
    <name>A0A174JFX7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoVAD</name>
        <name evidence="1" type="ORF">ERS852471_02691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267372.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96020">
        <property type="protein sequence ID" value="CUO96020"/>
        <property type="gene ID" value="ERS852471_02691"/>
    </dbReference>
    <dbReference type="OrthoDB" id="646737at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010894">
        <property type="entry name" value="SpoVAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038369">
        <property type="entry name" value="SpoVAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07451">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011570">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02845">
        <property type="entry name" value="spore_V_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO96020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="339" mass="36751" checksum="072741E8F0239214" modified="2016-09-07" version="1">MTSAAKKIGKQTIKLQNPPKIISTFSIVGPKEGDGPLKEYFHEIINDDTLGKDSFEKAESKMMYTAIKGAISGANLKEEDIDYLFAGDLLNQIVSSGYAARELNIPFFGLYGACSTMAESLSMASLFVDGGFARYVVASTSSHFSSAERQFRFPLEYGSQRNPTAQWTVTGSGAMVLSNYGDFPKVTYVTTGVVKDYGEKDSNNMGAAMAPAAVDTIYNHFKDTGRKPSDYDVIATGDLGKVGKEITEKLLLEYGYDIKDVYVDCGDMIFDDERQKTDSGGSGCGCSAVVTCGYFYKKLMRREIKKMLLVSTGALMSPTTSLQGESIPGIAHAVAIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JM69</accession>
    <name>A0A174JM69_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98275">
        <property type="protein sequence ID" value="CUO98275"/>
        <property type="gene ID" value="ERS852471_02748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO98275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="28066" checksum="BBEABA98AEBDE720" modified="2016-09-07" version="1">MMIEKLICFFRQLIIAIRRKKITCINDEKDVNIEEEIEAELNNETERDFIEVESSGKTTEVRRCEAVVILTNGVAISESFICDGTLNATDRSYLLIIIYKFNLAMGYAEVSISDFLAYTHTTNRTNVIKVIERLEKKEVIEKIKGGANDSNRFLVLKHMLIIGGSRIKYDTSNINDTSGKSIDEEIEYKDIIFKEVSEDEKLSTKYAALMIKDTCYKNIRELNGISENYTKLESIANELMKKQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JWX0</accession>
    <name>A0A174JWX0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein ERS852471_02821</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvcJ</name>
        <name evidence="2" type="ORF">ERS852471_02821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267612.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02267">
        <property type="protein sequence ID" value="CUP02267"/>
        <property type="gene ID" value="ERS852471_02821"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP02267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="294" mass="33527" checksum="2B37415A3AAD8D70" modified="2016-09-07" version="1">MRFIIVTGLSGAGKSEATNSLEDMGYFCVDNLPPTLITKFAEVCKQSDGKIDKVALVIDIRGGIFFDDLFDSLKELSKEQFKYEILFLDTSDEVLVKRFKEKRRSHPLSPGGRVITGIELEREKLREVKEKADIIIDTSKYAIKDLREEMLKNFGDVEAPQKQLSITVLSFGFKYGIPVDSDLVFDVRFIPNPFYIPELKPHSGNDEPVKDYVLQQEETKVFLEKAVDMLQFLIPNYNKEGKRQLIVSIGCTGGRHRSVAIANAIYEKLHASNYNVYVEHRDIKEDVHKGDKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K3X9</accession>
    <name>A0A174K3X9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pyrC</name>
        <name evidence="7" type="ORF">ERS852471_02873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267708.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04747">
        <property type="protein sequence ID" value="CUP04747"/>
        <property type="gene ID" value="ERS852471_02873"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="50"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP04747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="399" mass="44390" checksum="D1C99FC0B9325CE5" modified="2016-09-07" version="1">MSNLLIKNVNVVDAFQNFHGDVYIENGIIKEVGQDIKKDNVEIIDGNSLTLMPSFIDTHAHFREPGFTQKEDIETGSKAAVKGGYTGVCLMANTWPVCSNYEVLNHVRNRAKEVGLTDIHQCVSITENFKGSNIEHLNMFKDDKEVKAISDDGVGVMDSSVMMKAMEVARENNWIVMSHAEDKTFSKIDMRMAEDLMTIRDLYLAKVTKAHLHMAHVSTVESINAIERAKEEGVNVTCEVTPHHLALDSSISNYRVNPPIREKEDVETLIRAIRKGVVDCIGTDHAPHTEEDKKNGAPGMVGLETAFSICYTTLVKENNISLNKLSELMSRNSANILGMNKGLISVGKDGDMVLVDLNQKVTVDREKFVSRGKNTPFHGREYYGEVKMTIKGGNVVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9P9</accession>
    <name>A0A174K9P9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiR</name>
        <name evidence="3" type="ORF">ERS852471_02921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP06807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267793.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06807">
        <property type="protein sequence ID" value="CUP06807"/>
        <property type="gene ID" value="ERS852471_02921"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="103"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP06807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="242" mass="27619" checksum="34B20D40FC03A076" modified="2016-09-07" version="1">MNLLEKVKSLNELEYSIYVHLNKDKNKVKDLRLKEVADELHVSASMITRVCKKLGFDGFSEYKLHLRYNEENNRKVKDEKLNYLLDYFQRSTTENSILEIKKVANAIVNSNEVLFLGLGLSSAIAKYGALLLNRKGFRTAFVDDMSWRVENIYDSKTLAIILTVSGETEEVNKAILNLKTRDIKIVVISNSEMSTAASLADYSIGYYVPNSRDKYFHNSATQVPVIHIIESISDEVQNLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KCE6</accession>
    <name>A0A174KCE6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase oxidoreductase</fullName>
            <ecNumber evidence="3">1.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpnA</name>
        <name evidence="3" type="ORF">ERS852471_02945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.163" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267835.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07787">
        <property type="protein sequence ID" value="CUP07787"/>
        <property type="gene ID" value="ERS852471_02945"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055041">
        <property type="term" value="F:cyclopentanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="29614" checksum="CBBFC62206C7EE10" modified="2016-09-07" version="1">MRDYFEGRFEGKNMLVTGGTSGIGKAVCIRAAKEGAFVIIVGRNEERAQAVLSEIVQNGGKARFIKADVSREDEVTSLFNIINNEVGELHVAINNAGVVGHGERIDELSTEEWSRVINTNLNSAFYCCREEVKNMLNHKQGGSIVNVSSVAGTTGFYRASAYVTSKHALNGLTKAVANDLAKFNIRCNSVSPAVTATPLNDRSAQEIKVKLGTAMAQGKSLEEAKSETMIGGKTETLQKRSATPEEQAATILYIASEEAAHITGSIIMSDGGYTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEP9</accession>
    <name>A0A174KEP9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267882.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08926">
        <property type="protein sequence ID" value="CUP08926"/>
        <property type="gene ID" value="ERS852471_02971"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139611at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP08926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="113" mass="13621" checksum="14B42BAB4CDA0041" modified="2016-09-07" version="1">MKHIIYIIYIEDDLQKKKNIYYSEDKEEAYSKFNILLNKCIIKAYESIFRNENNYIFQSNHFKSISLSNKEKILIRTKEYVIYINDKGKIVGAVSFVNDFDRTYIERVVMEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KF34</accession>
    <name>A0A174KF34_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+-driven multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_18</name>
        <name evidence="2" type="ORF">ERS852471_03001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267947.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10502">
        <property type="protein sequence ID" value="CUP10502"/>
        <property type="gene ID" value="ERS852471_03001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="452" mass="48606" checksum="01466409BA4C3FE7" modified="2016-09-07" version="1">MTKDMTQGSPVRHILLFSIPLLIGNVFQQFYSMVDTIIVGRFVGVDALAAVGSTGSLVFLINGFALGLTSGFSVMVSQRFGANDEKGLRKAVSSSVVLCTALVIILTTISLIAAKPLLHLMNTPDNIFNDAYTYVAIIFAGIITTVAYNMMASILRALGDSKSPLYFLIISSVLNIILDLVFIINFKMGVAGAAYATIISQGVSAILCFIYILNKYTILKLAREDYNVKKSMYIRHLKIGIPMALQFSITALGLLTVQGALNVLGSTVIAAYTASSKALQLVMQPAVTYGVTMATYCGQNLGAKRYDRISDGVNKAVKISIITSLIAGFVLIAFGTQFVKLFIDNPDAQIIAYSKQVLTISGIFFIPLGLIFIFRNALQGIGESFVPMMAGVAELGARALVAFTLPSFLGFFGICLADPVAWIAAAVPLAIYYYITIKKLLAKYDTSVEVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KHU6</accession>
    <name>A0A174KHU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_19</name>
        <name evidence="2" type="ORF">ERS852471_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268002.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11512">
        <property type="protein sequence ID" value="CUP11512"/>
        <property type="gene ID" value="ERS852471_03030"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="457" mass="49014" checksum="B709222E949C4967" modified="2016-09-07" version="1">MKQKTLSLTEGAIGSTLLRFAVPFLLASLLQALYGAVDLFVVGQYADSAAVSAVAIGSQLMQTITGIVLGISMGGTVLIGHCIGEKNDKGAAKAVGTITILFIMIAAILTPIMIFGTNLSVSLMHTPTEAINYARQYIFICACGIPFIVGYNAVSGIFRGVGDSKTPMYFIAIACVVNIVSDFILVGKFNMGASGAAIATILAQAISLIISLIFIKKRGFSFEFNKEYVRVDKYSLRRILKVGSPLALQDALVNISFLLITVIVNSMGLIASASVGVVEKIIIFAMLPPTAFASAVATMTAQDMGANKPDRAIKGLKYGIGYSLICGILVCVYCQFLPHTITSIFTKDVEVIASAAMYLKSYSFDCILVAFIFCMNSYFSGCGRSMIAFIHSMIATFVVRIPMSYLMSKVPNTSLFKMGLASPVASIVSVGICFGYFIWLKKYNSQAKSTEEYITMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KPP0</accession>
    <name>A0A174KPP0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase sigma factor SigI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">sigI</name>
        <name evidence="3" type="ORF">ERS852471_03020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Negatively regulated by the anti-sigma-I factor RsgI.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RsgI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. SigI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267984.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11200">
        <property type="protein sequence ID" value="CUP11200"/>
        <property type="gene ID" value="ERS852471_03020"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1261602at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02064">
        <property type="entry name" value="Sigma70_SigI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014244">
        <property type="entry name" value="RNA_pol_sigma-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30385:SF6">
        <property type="entry name" value="PTHR30385:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038953">
        <property type="entry name" value="SigI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Polymerase core binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP11200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="221" mass="25582" checksum="0EDB2143F421EAD3" modified="2016-09-07" version="1">MEFIEENINDIKNTSIDKLIQDYMAFIVKTVSSITGRYVSVENDDELSIALIAFKEAIDKYEESRGSFSSFAKLVISSRVKNYLIKENRNNKVESIEALKDKGIDISEVAETVVEESDELSNEIGKLKNEIEAFGFTFEDLVDEAPKHEDTRRNAIELSEKVSKEKPLTSFMYEKRRLPIKQISVKFSVTEKVIKRSKKFIISVVIIIDKNFRNLRLWIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQW1</accession>
    <name>A0A174KQW1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA/TS-N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268057.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13181">
        <property type="protein sequence ID" value="CUP13181"/>
        <property type="gene ID" value="ERS852471_03058"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1760987at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025642">
        <property type="entry name" value="DUF4342"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14242">
        <property type="entry name" value="DUF4342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4342" evidence="2">
        <location>
            <begin position="83"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="21019" checksum="F28AF76CA98BEFBC" modified="2016-09-07" version="1">MDKLKLVDRLREKANISYEEAKIALENSNWDILEAMLYLEKHGKVNSPSVSIFYSNEYSESYTEHEETHNNDDNINSDNSKSKDNFEGIFEAICKVIDTGNNIFLQVKKSNRVLVKIPLTVVVVLLFFAFWVIIPLIIVALFFDIEISLSSKRFDTDKIDKVNEAFRYLLKVAQDIKKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L3M4</accession>
    <name>A0A174L3M4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268246.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18842">
        <property type="protein sequence ID" value="CUP18842"/>
        <property type="gene ID" value="ERS852471_03167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP18842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="17990" checksum="D8775D5149A15ED7" modified="2016-09-07" version="1">MSFFVWKTSIQCKLNDIKTDIVGSHRERETNRYIRKTKQEANPSIVTTKERLEYYLKKKYNLIYIEGELYHEMEQKDYKKILNSFGKTMSKIGKNTALVSGVVTAGMSSFTIPLALSSMFLGVISKSDLDNYEYIIDKNEKRIILKHKGYNPKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L7N0</accession>
    <name>A0A174L7N0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">glmM_2</name>
        <name evidence="6" type="synonym">glmM</name>
        <name evidence="13" type="ORF">ERS852471_03143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268206.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17569">
        <property type="protein sequence ID" value="CUP17569"/>
        <property type="gene ID" value="ERS852471_03143"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="157"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="258"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="373"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP17569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="446" mass="48268" checksum="7147EBD7CEE1B06F" modified="2016-09-07" version="1">MSRMFGTDGVRGVANTELTADIAYSLGRAGAYVLTEGTHKPKILVAKDTRISGDMLEAALVAGILSVGAEAVLLGVVPTPAVAYLTRKYNADAGVMISASHNPVQDNGIKFFDNRGYKLDDSIEDEIQRVIESNFADVPSPIGGAIGRCSTEPRALDEYIDFVKSTIPGDLKGVRVGLDCANGAAYEAAVKAFRELGAVVRVINDNPDGENINDACGSTHPEELMDYVVRKKCDLGFAFDGDADRCMAVDENGKLIHGDYILTLCAKHLKDEGKLKDDTLVVTVMSNLGLDIACKEEKIKTVKTKVGDRYVLEEMLKNGYVLGGEQSGHIIFLEHNTTGDGLLTALQVAAIKKQTGKTLSELAGIMKELPQVLVNARVTNDKKNIYLEDEEIINSIKEIEAKLDGKGRVLIRPSGTEPLIRVMLEGENQEEIDKMANDLVNLILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L900</accession>
    <name>A0A174L900_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction-modification system methyltransferase subunit</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18255">
        <property type="protein sequence ID" value="CUP18255"/>
        <property type="gene ID" value="ERS852471_03153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP18255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="33670" checksum="D467ABAEB5E60408" modified="2016-09-07" version="1">MFVQSLKFVQEHSGNAFDISVYGQESNPTTWKLAKMNMAIRGIENNLGSKNADTFHEDLHSSLKADFVLANHPFNQSDWGQPLLVNDSRWKFGTPPANNANYGWIEHMLDKLSQKGGAAVVLANGSLSSNTSNEGEIRKSILEADLVDAIVALPDKLFYTTGIPVCIWFFNRDKKNKGETLFIDARKMGTMVNRRLRELTDEDIKEVANIYHAYKNNENYEDKQGFCKRATIDEIRANDYILTPGRYVGIEEVEDDGEPFEEKMERLTKTLSEQFKKSKELEEEIRKQLGGIGYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LPY6</accession>
    <name>A0A174LPY6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glgP</name>
        <name evidence="11" type="ORF">ERS852471_03274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000037">
        <property type="protein sequence ID" value="CUP25041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268434.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25041">
        <property type="protein sequence ID" value="CUP25041"/>
        <property type="gene ID" value="ERS852471_03274"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP25041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="811" mass="92906" checksum="FAF09A46094593D2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LT96</accession>
    <name>A0A174LT96_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24719">
        <property type="protein sequence ID" value="CUP24719"/>
        <property type="gene ID" value="ERS852471_03271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP24719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="243" mass="26489" checksum="89060CF58360E842" modified="2016-09-07" version="1">MDIDGICHSAFCGRLEARFPGRAILYTTSPGLGLAKPDKSRLFSLLTVHSRPPFPFTFCFLPPVNSGGTAGAVFCPVGFGDEHTAADLTAFQVLIPENLRFQRPVQRQDRPAEPLTADRERNRLRTGAGVPIVKDNAVAVLTATALPAYQAGRLFSLRRGHAVKGTVRPAFQRRQVFIGVISHAFPPFCFPLPFSPKRFPAPFLRRVPALARSSQLRDILSRSPTPCGASPAGVFLFGRLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LYN3</accession>
    <name>A0A174LYN3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000042">
        <property type="protein sequence ID" value="CUP27078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268480.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27078">
        <property type="protein sequence ID" value="CUP27078"/>
        <property type="gene ID" value="ERS852471_03305"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP27078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="52452" checksum="6B9EFE8DE074ED51" modified="2016-09-07" version="1">MDYDVLVLGGGIIGCAAAYELSKYNLNIAVIEKEYDIADDISFVNSAIVYDGSETSNNVMAGLEYIGNILLEDLCGKFNVPFKRIGGLRVVDDDNGVIKLKEMYERAIKRGIDGVHLIDSDEVYKIEPNINPGIKKGLYSQNVALVAPYDLALSYAEVASDNGVIFRLEEEVLNIMNIAKGFKVITNKNKFTCRVVINTIANEMFINESGVVQEKDELKNENTFKNMSYILVDDSYKNKLSRIITKTFDKDTFVVSTPVLNGGSLIGIKSIEKTSLDDNISYATKLLKDLDKNSINNLFRESYDKDSIVVDDSRIDRGFISVTGTHYGKITLAPAIAKMLCDTLTNTLKCSQKKHFIDKRRESYKFREMNKDEINEVIKVDNRYGKMICLCNNVTEGEIVDSIRRPLGARTVKGVKRRTGAGFGSCHGAYCNEKIVSILARELGKNITDIVDDSKDSKIISGRIKEFEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LZN6</accession>
    <name>A0A174LZN6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_03326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000046">
        <property type="protein sequence ID" value="CUP28441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268514.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28441">
        <property type="protein sequence ID" value="CUP28441"/>
        <property type="gene ID" value="ERS852471_03326"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="61"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP28441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="253" mass="29033" checksum="C5BFAADCA83730B9" modified="2016-09-07" version="1">MSTSHYSLKNNKYIIFSIVIILLIWQVTSIYIGNRLLFPSVTDVIKSMIEIVTQYNFITIIFYSIIRGIKSFFISLSVGLILAILSYFNKIVYNCILPILSIIKAVPTMAFIVLLLIWTSKDYAPIIIGIMISLPIFYDVILNTIMNLDKNLLQMCDVYDIPTRDKMKDIIMPIVIIELAKVLSSTFSLIFKVVISGEVYSQPKYGIGAIIQLEKMQLNTAHIISWIIIITIISYVFDLLFKVIDKRYIHKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLM4</accession>
    <name>A0A173XLM4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2922)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262776.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52801">
        <property type="protein sequence ID" value="CUN52801"/>
        <property type="gene ID" value="ERS852471_00070"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034992at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021321">
        <property type="entry name" value="DUF2922"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11148">
        <property type="entry name" value="DUF2922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="71" mass="8056" checksum="2588CF4DBD421E67" modified="2016-09-07" version="1">MEYTLSMTFLTETDDKYTLSISGVRQNLNSQEVSDLMDIILENDIFISKKGAIASKYAAKVTERQITKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLS6</accession>
    <name>A0A173XLS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YvrJ protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262780.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52882">
        <property type="protein sequence ID" value="CUN52882"/>
        <property type="gene ID" value="ERS852471_00072"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2099215at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024419">
        <property type="entry name" value="YvrJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12841">
        <property type="entry name" value="YvrJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7047" checksum="FC2225702E3A1A8E" modified="2016-09-07" version="1">MEINELLNLIANVGFPVAISAYLLVRLEKQIMNLTYSINKLNTIVSTKLGIVIDNDEITKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XN26</accession>
    <name>A0A173XN26_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized Fe-S center protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262756.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52346">
        <property type="protein sequence ID" value="CUN52346"/>
        <property type="gene ID" value="ERS852471_00060"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1000643at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="32"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="289" mass="31692" checksum="4502F7BDD5170A63" modified="2016-09-07" version="1">MEKSKVFFTSEITPENMIKMYNALGVKSEGNVAVKVHSGEVGNQNFIRPEFMKPIIDYVNGTVVECNTAYEGKRNTTEKHKETMELHGWNSVANVDILDESGDMELPINGGKHLKTNYVGKNMDKYDSMVVLSHFKGHPMGGFGGALKNISIGLASSHGKAYIHGVGKPEELWTADHNSFLESMADASKSIMEYYKDKIVFINVMCNMSVDCDCCAVAEDPKIGDIGILSSTDPVALDQACLDLVYSSKDPGKSHLIERIESRNGVLTVKAASELGVGNRDYDLIVIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRU0</accession>
    <name>A0A173XRU0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA/RNA helicase, superfamily I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_00077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262789.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53138">
        <property type="protein sequence ID" value="CUN53138"/>
        <property type="gene ID" value="ERS852471_00077"/>
    </dbReference>
    <dbReference type="OrthoDB" id="616258at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024402">
        <property type="entry name" value="DUF2726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10881">
        <property type="entry name" value="DUF2726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="174"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="901" mass="104124" checksum="B61F220B429B1972" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXS6</accession>
    <name>A0A173XXS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic-acid-binding protein implicated in transcription termination</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262932.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56862">
        <property type="protein sequence ID" value="CUN56862"/>
        <property type="gene ID" value="ERS852471_00156"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2067975at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="88" mass="10089" checksum="F541C3E591BF19AD" modified="2016-09-07" version="1">MKVKKIPLRMCTGCMEMKPKKELIRVVKSPDGEVSVDLTGKKSGRGAYVCKNSECLEKAFKAKRLSRNLDVVIDEEIYNRLRNEIENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YII9</accession>
    <name>A0A173YII9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, pyridine nucleotide-disulfide family</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trxB_1</name>
        <name evidence="2" type="ORF">ERS852471_00246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263123.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63559">
        <property type="protein sequence ID" value="CUN63559"/>
        <property type="gene ID" value="ERS852471_00246"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN63559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="287" mass="31967" checksum="0C9844352A1A918B" modified="2016-09-07" version="1">MERYDIAIVGSGPAGLSAALNAKIRNKKFIIFGNKNLTNKLVKAPKVNNYLGFYGMNGEEIKNKFQEHLDAMNINITYERVNNIYAMGDYFALMVNEKMYEAKTLILATGMEYTKAIKGELEFLGRGVGYCATCDAPLYKNKVVTIIGYNKEAEEEARYVSELASKLYYVPMYKGEYELNDSIEVIHDKPVEISGELKVNKLKLENAELETDAVFVLKDTISPGQLVPGLEIEDGHIKVDREMKTNIEGCFAAGDCVGKPYQYIKSAGEGNIAALSAVKHLDNLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRH1</accession>
    <name>A0A173YRH1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II L-asparaginase</fullName>
            <ecNumber evidence="9">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ansA</name>
        <name evidence="9" type="ORF">ERS852471_00302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263225.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66494">
        <property type="protein sequence ID" value="CUN66494"/>
        <property type="gene ID" value="ERS852471_00302"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1659551at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="8">
        <location>
            <begin position="208"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN66494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="323" mass="35333" checksum="735B32CF2C91318D" modified="2016-09-07" version="1">MKKIAVIFNGGTISMKVDERIKAAVPSLTGEEIMSMVTGIENYAEIESYTFSSMPSPHMTFETILELSNFVTELVNRSDIDGIVITHGTDTLEETAYFLDLTIDTSKPIVITGAMRSSSELGYDGPFNLATSICTAISDDSIGRGVLVCFNGELNSAAEVTKANSMALNAFRTPNFGPIGIVDNNKVIFYRNTINTSKYKVNKIDKEVALIKCAVDMDSTFIDFIIEKGYGGIVIEALGRGNVPPRMVPGIKRAIENNIPVVIVSRCFEGRVHESYGYEGGGKMLLDLGIIFGDTLPGQKARIKLLLSINSELDLEQIRKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYR3</accession>
    <name>A0A173YYR3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnc</name>
        <name evidence="10" type="ORF">ERS852471_00335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263283.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68406">
        <property type="protein sequence ID" value="CUN68406"/>
        <property type="gene ID" value="ERS852471_00335"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN68406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="232" mass="26860" checksum="D51804F5F7819988" modified="2016-09-07" version="1">MNNFYQKEVEDVVGIKFNEPSLLMTALTHSSYANQHRDEAYNERLEFLGDSILQLCITEYLFLNYKDKTEGELTKIRSLIVCENSLYEIGRELNLGYFLRMSKGEELTGGRERVSLIADAVEALIAAIYLDKGLEFTKDYILGRFEKIIKRAINNDIILDYKTKLQELLQRNGEISIVYELIKHEGPPHRRKFFTQLIIDNKEFSKGEGYSKKESEQNAAKSALKILEDINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7Y5</accession>
    <name>A0A173Z7Y5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ERS852471_00387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263373.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71308">
        <property type="protein sequence ID" value="CUN71308"/>
        <property type="gene ID" value="ERS852471_00387"/>
    </dbReference>
    <dbReference type="OrthoDB" id="93144at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="279"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN71308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="585" mass="67965" checksum="21971513D75B351D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYH1</accession>
    <name>A0A173ZYH1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">degV_1</name>
        <name evidence="2" type="ORF">ERS852471_00523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263634.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81341">
        <property type="protein sequence ID" value="CUN81341"/>
        <property type="gene ID" value="ERS852471_00523"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="30991" checksum="E94D714BBB037B2A" modified="2016-09-07" version="1">MNKIALITDSTCGLPKKYIDKYNVHIVNLKIIYKSGEFIDGINITADEVYSRIEEELPTTSMPSVQDACDLYDKLISEGYTHAIILPISSGLSGTINSFRLASEQYDDKITSFIFDTKILSMAVGLIVIEVGKMINNGESFDTICKTIPILREKVNMYFTVDTLEYLIKGGRIGKVTGGIGEMLNLKPIITMADDGSYTNFAKVRGSKQAFNKLVKLATEILDRGKGRVIIMTGTMHKEAEELKAILEKHPNTTFMHCGTITPAVGIHSGPRLLAVAVMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2T4</accession>
    <name>A0A174A2T4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263643.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81708">
        <property type="protein sequence ID" value="CUN81708"/>
        <property type="gene ID" value="ERS852471_00528"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN81708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="12840" checksum="39A3516B21E48C87" modified="2016-09-07" version="1">MLSKKDIKLITIIIGISLIIWIGYTLMRPKGPSIEVIHGNTVVERLDPKVDGRYTIQGSYGELVVEVKDGKFRITDEECPNHVCSAMGWVDSDGYLPILCLPNEVMVGMEGQFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5U2</accession>
    <name>A0A174A5U2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263673.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82865">
        <property type="protein sequence ID" value="CUN82865"/>
        <property type="gene ID" value="ERS852471_00546"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="221" mass="25550" checksum="692D93709809BEFD" modified="2016-09-07" version="1">MDKINTVIFDMDGVIFDTERIYLEAWTEVFDKYGYKMTKEVYTSVMGVGRKNVINTFKRIYGEGLPIDKMYKEKDDILFNRIENGTVPTKEGVYELLKFLRENNYNIALATSAKRERVDKHLKESNLEGVFNVSVCGDEVEKAKPNPDIFLKAANKLEVDSENCIVVEDSLAGVKAAYNAGMLVVNIPDLRDYDDEMKKFSHKVFKNLIDFKEYLNFQINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJH4</accession>
    <name>A0A174AJH4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family protein</fullName>
            <ecNumber evidence="10">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">chbF_1</name>
        <name evidence="10" type="ORF">ERS852471_00622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263818.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88537">
        <property type="protein sequence ID" value="CUN88537"/>
        <property type="gene ID" value="ERS852471_00622"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="198"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN88537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="471" mass="53004" checksum="B5F71A35EB5BD369" modified="2016-09-07" version="1">MEKRPIKIVTIGGGSSYTPELMEGFINRYHELPIREFWLVDVEAGREKLEIVGAMAQRMWDASGHDVKVHLTLDRREALKDADFVTTQFRVGLLDARIKDERIPFSHGMLGQETNGAGGMFKAFRTIPVILDIVEDMKELCPNAWLINFTNPSGMVTEAVIKHGGWKKCIGLCNVPVGAMMGEPKLIDKKEDELIFQFAGLNHFHWHKVSDKQGNDVTAEIIKNMYDRKEDDGTPANIHNIKFLREQLEQMNIIPCGYHRYYYLQDEMLEHGLEEFNGEGTRGEQVKKTEAELFELYKDPNLNYKPEQLTKRGGTHYSDAACECINAIYNDKKIPMVVSTQNNGAIPDLAPDSIVEVTSYITAAGAMPVAWGKLNSAEKGWIQVMKAMEECVIEAAINGDYGLALQAFLLNPQVKGGAIAKTVLDEMLVAHAKYLPQFAEKIAELKEQGIRSNDPVVMEIMERENKVVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATJ6</accession>
    <name>A0A174ATJ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha amylase</fullName>
            <ecNumber evidence="3">3.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">malL</name>
        <name evidence="3" type="ORF">ERS852471_00656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263874.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90768">
        <property type="protein sequence ID" value="CUN90768"/>
        <property type="gene ID" value="ERS852471_00656"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="13"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="542" mass="63635" checksum="F6C626058E414566" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVY4</accession>
    <name>A0A174AVY4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN92089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263912.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92089">
        <property type="protein sequence ID" value="CUN92089"/>
        <property type="gene ID" value="ERS852471_00678"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="395"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN92089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="494" mass="57842" checksum="44DFA39339591B34" modified="2016-09-07" version="1">MNILLVDDEYLIRAKLLKYLKDSTFKFNNIYEASDGLEALEIIRTNSIDIAIIDIHMPKITGIELLQTLRSELYKTNIIFLSGFEKFEYARQAIKYNTVEYLLKPVKKSDLYNAIEKCISLIEKSDQNLVAIHELEEKSKYQYIVDSIYNDLDIKNSPLTITDNNYIFISVELFHESYLNKLYSFLENNFETFDVIYGLSKKNKILLVNCIYSDNIKARFNSLIENKILSYCYFNKDSKDIKKLKDSFFECITLFPAKIFFDKFSIFTFNDIKYKACTLPNTLKLDFELLARSNTSNNLVNTFEFYIDKVSDIKDIYALKLLVNCFLSSIEDVFLEGNGEYLSLINLDHLITNLLYTSKDLNSIKSYCYNCYDRLSKEKSTTRNNKNSISSKTIIKVKEYIDQNYYSDNINLDYLSSHFYINSCHLSSTFKKIIGESLVEYITKKRITEAKSLLKNDDIKLSEVAEKVGYKDYYYFSKLFKKHVGVSPLKYKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGS4</accession>
    <name>A0A174BGS4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264095.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98950">
        <property type="protein sequence ID" value="CUN98950"/>
        <property type="gene ID" value="ERS852471_00768"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="31029" checksum="75FABBD69FE62016" modified="2016-09-07" version="1">MKSVDLHIHSCYSDGIYTPEQIAKTAKEKGIKCISITDHDSIAAQYIVNTEYNNKDLKIIPGIELSTEYKEMELHILGYFIDIENNNLKCLVDNLNKQRLKRVEKILYNLKGYDINIQLDDLGVDLNSTIGRSHIANAMVKKGYFDNYKTAFKSYLIKGKPGYVKGFKLTYREALDIIMESGGVPVLAHPGQIYKKIEVENIIKELKCFGLSGVEVYHPSHSAIDTNKFFNMAKKYKLSITGGSDFHGRANFDEQSIGSCGINDILLNKFIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPW6</accession>
    <name>A0A174BPW6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264203.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01730">
        <property type="protein sequence ID" value="CUO01730"/>
        <property type="gene ID" value="ERS852471_00822"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1750801at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031360">
        <property type="entry name" value="TrpP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17099">
        <property type="entry name" value="TrpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="19710" checksum="DCF3BC1712C3AC95" modified="2016-09-07" version="1">MKRNSNTKKIVINALLLGIGAILHQITPALGIPMQPDFALAMLFIVMIINFGDYKTSLIAGIVTGIFTALTTKFPLGQVPNIIDKIVTVNLIYILMIFMKQFVKRGFEINNMKLSIIAIIFSLGTLISGTTFLVSAQILVGLPMNFGILFTTVVLPAVIINSIAGIFLFKIVVSSLKRIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQI4</accession>
    <name>A0A174BQI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system mannose/fructose/sorbose family transporter subunit IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">manZ_1</name>
        <name evidence="10" type="ORF">ERS852471_00824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264207.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01826">
        <property type="protein sequence ID" value="CUO01826"/>
        <property type="gene ID" value="ERS852471_00824"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1632067at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO01826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="30839" checksum="68E305E31F41682B" modified="2016-09-07" version="1">MEFNSTQYKDLTPAKQLDKKTLNKMVWRSLFLQASFNYERMQAAGWLYGILPGLKEIHTNKDDLSKSMKHNLEFFNTHPFLVTFVMGIILSLEQQKADTNTIRAVRVAAMGPLGGIGDAIFWFTLVPITAGITANMAINGSLAGPILFLLIFNAVQFGVRYWLMHWSYNLGSKAIDILTKNAKEFTRAASMLGVFIVGALTSNYGATKLGIVIPNGEAPIDIQAILDGVLPQMIPLALTLLLFFLLKKKGWKPVTCIALLLVIGIVGAFIGHLGGFTMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRI6</accession>
    <name>A0A174BRI6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264250.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03223">
        <property type="protein sequence ID" value="CUO03223"/>
        <property type="gene ID" value="ERS852471_00850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="16093" checksum="9A66830D36F31598" modified="2016-09-07" version="1">MWSEKRGIEGTIVFAIFPIVWCILGNISYYLSGIERFYNFTSVINIENSTIMAILPLIVVVIAAIVNLKIYVDEEKLFEVNKSMFKYKIVNILFIAYIIFAISVIRDSKVIISALLIELSFICIYILKRKAKSLELTDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BVP0</accession>
    <name>A0A174BVP0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type sugar metabolism regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhaS_2</name>
        <name evidence="2" type="ORF">ERS852471_00859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264268.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03720">
        <property type="protein sequence ID" value="CUO03720"/>
        <property type="gene ID" value="ERS852471_00859"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="289" mass="34078" checksum="A90998DEB59B4CCF" modified="2016-09-07" version="1">MDSSFTLKEISILKNSPLKYKSTLGHSLIYFRKGSCIVNIYTESFIASHHSYILLRDEEQLLLTNDHTTECTIYILSFSYNHFDNSSKDLLLECFDKKSLDKCRYIISQSENSMRVRTLLILLNIELKEEKYASDLFKSNTLSMILVILNRIILENIEPEKKCCKKGLRLDDIFSYINSHLKEEISLDKLAEDLFFSKYHILHEFKKKTGISLYRYIIKRKLEYSKTLIESGMPIREVYHHCGFGDYSNYFRSFKKEYECTPKQYYNQVRSKSILADLKFEITPSNIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BWL2</accession>
    <name>A0A174BWL2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsU_1</name>
        <name evidence="4" type="synonym">rpsU</name>
        <name evidence="7" type="ORF">ERS852471_00865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264276.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04040">
        <property type="protein sequence ID" value="CUO04040"/>
        <property type="gene ID" value="ERS852471_00865"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO04040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="58" mass="6916" checksum="8A3006CC4F4671A1" modified="2016-09-07" version="1">MSEVRIRDNESLEQALRRFKRKCANAGVLAEAKKREHYEKPSVKRKKKSEAARKRKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C606</accession>
    <name>A0A174C606_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264403.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08393">
        <property type="protein sequence ID" value="CUO08393"/>
        <property type="gene ID" value="ERS852471_00920"/>
    </dbReference>
    <dbReference type="OrthoDB" id="997658at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="24064" checksum="6A96CA883DE73D17" modified="2016-09-07" version="1">MARTYAYSADFDKEVENLFREAEFLGEGHNGIVYEVPGNKALKIFLEKKICKEEADILEKVRRSKYFPKIYSRGDYYILREKVDGMRLDHYIEQYGLTEKLSYNLYKLIKEFEELRFTKLDIRCRDVYVGDDERVMVIDPKQCYRRKVSYPRHLMKGLNGINVLDQFLNYVERFDKKTSLEWGKKMEQYYYKQDNEEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFK1</accession>
    <name>A0A174CFK1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nth</name>
        <name evidence="7" type="ORF">ERS852471_00957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264473.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10286">
        <property type="protein sequence ID" value="CUO10286"/>
        <property type="gene ID" value="ERS852471_00957"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO10286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24438" checksum="CA3EFB1E785B278A" modified="2016-09-07" version="1">MKQRTKAILDILKELYPDAKCELEHNSPFQLLVATILSAQTTDKKVNEVTETLFRDYPDLDAFLTLSIDELEERIKQIGLYRSKAKNIMIMCNQLKNNFNGEVPKTMEEIVTLAGAGRKTANVVLSNAFGVPSIAVDTHVFRVSNRLGLADSDNVLEVEKQLQKELPKKEWSLAHHLLIFHGRRCCIARNPKCGECRLQSRCKYYKELKKNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJU8</accession>
    <name>A0A174CJU8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxyethylthiazole kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264529.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12078">
        <property type="protein sequence ID" value="CUO12078"/>
        <property type="gene ID" value="ERS852471_00995"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2158824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="31085" checksum="B4AF63AA9D17E77F" modified="2016-09-07" version="1">MKLSSETITNAFNLRMFKELVIQCIVSKDRINDIRETIESYNNNIKLIYEITENDEVNIDGLLINLEHLESENLIEIEEYLISSKKSKEIILDLCGINKSRDNRDLILSFINRYDIDIVKGTKEEVISLIDGQKYYLSSQDDKYRDFSRKNNTILIIKDTNYWITDGYSEFTVSIEENLLDDKEFEDILTGLILACTALYDRKEQRVEAILLAINIFEISKKVALKRVEIDGFKNLIKEYLIREIASLNSEEIYKISEIGYRFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNJ2</accession>
    <name>A0A174CNJ2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cardiolipin synthase</fullName>
            <shortName evidence="12">CL synthase</shortName>
            <ecNumber evidence="12">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls</name>
        <name evidence="14" type="ORF">ERS852471_01016</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phospholipase D family. Cardiolipin synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13338">
        <property type="protein sequence ID" value="CUO13338"/>
        <property type="gene ID" value="ERS852471_01016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01916">
        <property type="entry name" value="Cardiolipin_synth_Cls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030874">
        <property type="entry name" value="Cardiolipin_synth_Firmi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="477" mass="55566" checksum="00323D91AE6C25C8" modified="2016-09-07" version="1">MGAYIFLAALIFFINMVLVFSLIFIERKEPDTTWAWLLILLILPGIGFIIYLMFGQNLSRQKLFREKKIIDKVKTKAVKEKHELSKKDDKKFIDNYKSLILMNYNHSGSIFTNGNDVKTYINGEDKFRDLFNDIRGAKKFIHIEYYIFRFDDLGKALINELKLKIEEGVEVRLLVDGMGSKSLKKKEIRYIESIGIKFSVFFPGILPHINTRINYRNHRKIVVIDGDIGYVGGFNVGNEYVNRGKQFEFWRDTHIRVQGEAVNELNKRFILDWDYAAEENINDMTEFFPEHKIYGDVGMQIVSSGPDHMEEYIKNAYMKIINDAKEYVYIQTPYLVPDGPVIEALKISALSGVDVRIMVPGKPDHFFMEWMLSANIGLLLDYGIKFYRYQKGFIHAKTIVSDGKVCSIGTANLDIRSFKLNFEVNAIMYNEKISKEQENIFYKDQKKCKLVTKKEYDNRSRALRIKESLIRLIAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPA5</accession>
    <name>A0A174CPA5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO14807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264557.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14807">
        <property type="protein sequence ID" value="CUO14807"/>
        <property type="gene ID" value="ERS852471_01020"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1692878at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO14807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="121" mass="13831" checksum="C9108B1F22BC9D02" modified="2016-09-07" version="1">MKSYSQEELENALKIISSTISTCEKIQPKFREGTSQFSLLRNRIKALKISKCLIENDGSIKEYIVDDLEKALPPVISIINKTEKAQSKYDEGSTQFKKFSPLIEAMYIARALITNEIIKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPB6</accession>
    <name>A0A174CPB6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">macB_3</name>
        <name evidence="11" type="ORF">ERS852471_01031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264567.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15361">
        <property type="protein sequence ID" value="CUO15361"/>
        <property type="gene ID" value="ERS852471_01031"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO15361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="863" mass="94836" checksum="865BDD940E1172AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWU8</accession>
    <name>A0A174CWU8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase class A-like protein</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">per1</name>
        <name evidence="2" type="ORF">ERS852471_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264580.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16026">
        <property type="protein sequence ID" value="CUO16026"/>
        <property type="gene ID" value="ERS852471_01045"/>
    </dbReference>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="51"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="32141" checksum="B89687070D41E4C0" modified="2016-09-07" version="1">MLYNALLFPLFFSMSLFMNRGQVESSPDIKRAVEECIDNYSENVAVYYYRLDGKKEYYLNEDKVFRAASLSKVPQAMEVLDKVSNGELSLDTIIEYSEEDYEEGTGILKLKENIGSVTVKEALELSLLYSDNIANNMLNRICGYDLNYYISKLSGEDITVGNITTAKEQVEIYRKLYSDEKYSLILDLLKKTCCHDRLDKYIENDKVAHKFGNYYRYYHDAGIIYDENPYILVVLTKDIGALSEVLEDGAIEDERRLIDDGEKSCELIAEISIKIYQCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5B4</accession>
    <name>A0A174D5B4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264628.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19255">
        <property type="protein sequence ID" value="CUO19255"/>
        <property type="gene ID" value="ERS852471_01108"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2075655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="183" mass="20181" checksum="BA779C3244D4C192" modified="2016-09-07" version="1">MPKEKKLETEVVLCTGKADIFKEVILTFPGPTLPFFVEDVDVKLQNVDLQVVNEKCCNSVIFSGQLFINVIYKISSGSATAGTDGSYTVSGAVNHITQVVPVSGCIPIDCECISKCDKNIRAKLLDVCVMENHKLVGINHPEIPFPTYSRLSEQVCIKIKVKVVTDEIITINLEDEDDKKCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DA87</accession>
    <name>A0A174DA87_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sapB</name>
        <name evidence="8" type="ORF">ERS852471_01148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21209">
        <property type="protein sequence ID" value="CUO21209"/>
        <property type="gene ID" value="ERS852471_01148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO21209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="25550" checksum="B265FE72559B7BFD" modified="2016-09-07" version="1">MYYVIESWCAMSELISELGIVDTFFKLLLALICGGILGIDRGRKNRPAGFRTYMLVCVASAIVMITNEYITTKYGGDPSRMGAQVISGIGFLGAGTIIVTGRNRVKGLTTAAGLWASACIGLTIGIGYYSGAIVGCLMIFVAMELLHGLEKNLMYKTKEITLYVEFSSITDIGKFIKSIKINGLKVSDMELIKSNNINEPIVGGIFTITSPKMTSYDHVIEILRKSEGICTIEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNY0</accession>
    <name>A0A174DNY0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA_1</name>
        <name evidence="7" type="ORF">ERS852471_01215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264734.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25570">
        <property type="protein sequence ID" value="CUO25570"/>
        <property type="gene ID" value="ERS852471_01215"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO25570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="32331" checksum="255438488125BC34" modified="2016-09-07" version="1">MKGIILAGGSGTRLFPITKAISKQMVPIYDKPMIYYPLSVLMLAGIREILIISTERDIGYFKELFKDSLEIGLTIEYAMQKVPNGLADAFIIGEEFIGDDTVAMILGDNIFYGQNLTDYLLEASSLKSGAVIFGYYIQDPREFGVIEFDEDNKAISIEEKPAIPKSKYAVPGLYFYDNSVVKKAKELKPSPRGELEITDLNRLYMDESKLKVIRLGRGMVWLDTGTHSSMLKAANFVEVIQDTHGIYIACLEEIAYRQGWITAEKLSELAKPLMKTGYGKYLISIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DV11</accession>
    <name>A0A174DV11_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ORF">ERS852471_01292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264863.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29313">
        <property type="protein sequence ID" value="CUO29313"/>
        <property type="gene ID" value="ERS852471_01292"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO29313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="94" mass="10639" checksum="91DDD52863046BB9" modified="2016-09-07" version="1">MGNVGGMLATFLPLVIMFGLMYLLLILPEKKRTKKYNAMLSELKVNDEIITRGGLVGKIITLEDEYMVIQSGPDRTRFKMLKTSVSQKINKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVD3</accession>
    <name>A0A174DVD3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO/MBR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27850">
        <property type="protein sequence ID" value="CUO27850"/>
        <property type="gene ID" value="ERS852471_01261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="204" mass="23693" checksum="CF5180D040637EB8" modified="2016-09-07" version="1">MSKKEKKEIKHKKSINNKIEKQQKKLAKKLKKKEKGSIIGRIFKVNNKFNLVALIKNILLPLGGGLLIGFLTRNSMVVYNSLKKPIFTPPSFVFPIVWTILYILMGIAAYRVYMNNKAGKDDKGAYFYYLIQLSINFLWSIIFFNLRLYGISFIIIIILLVLIILTIIKFFKVDKIAGVLMIPYILWVSFAAVLTFFIWMLNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E1U8</accession>
    <name>A0A174E1U8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fe3+-siderophore ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">feuC_2</name>
        <name evidence="8" type="ORF">ERS852471_01308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264891.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30050">
        <property type="protein sequence ID" value="CUO30050"/>
        <property type="gene ID" value="ERS852471_01308"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO30050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="346" mass="37220" checksum="2F0DF4C39D59B1D5" modified="2016-09-07" version="1">MKDIIRKNKGKCFVILIIAFVFLTMIAVSVGSASISVKDVFSTIFTRIPFIGNKLEGGSFNTHALIIFKLRMPRIVMATIVGMGLAVVGGSYQAVFKNPMADPFILGISSGAALGATISILFDLKSSFFSFSLTTLFAFIGAMVTTFLVYTLGRVGRRVSTTNILLSGVAISFLMNAMQSTLMIMNEDKLESVVFWTMGGLSTSSWKTISIVAPCIILGVIYLTMHSRDLDIILTGDDTAKSLGVDTNKLVRRVIIVSSFIIAASTAFNGIIGFVGLIIPHIIRMIIGPEHKYFFPFAAVGGAMFLVLADTVARTVASPAELPIGAVTAMIGAPYFIFLLNKHKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2Q5</accession>
    <name>A0A174E2Q5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glpR_1</name>
        <name evidence="4" type="ORF">ERS852471_01358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264981.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32061">
        <property type="protein sequence ID" value="CUO32061"/>
        <property type="gene ID" value="ERS852471_01358"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="28371" checksum="3FAFC8A7F3593497" modified="2016-09-07" version="1">MFAEERLDQILNILNSEGKIKVKNLSQHFNVTEDCIRKDLKHLENLGHLKRTYGGAIKVRQSTTQYDTIERSKTDVSIKSKIAEKAFNLIKDRETIFLDLSTINMLIAKLLSQSNKRVTVVTNMLDIINILSSTENNVTVIATGGLLNKSLNGFAGATAISFIEKYKFDISFIGSCGIDVFDKSITTFEIEDGLTKTAIIKSSKKAFLVMQQTKFNTDGNFKFSNIESINGIITDSLPSIDIVDILHENNIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGJ0</accession>
    <name>A0A174EGJ0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="3">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnC_1</name>
        <name evidence="3" type="synonym">asnS</name>
        <name evidence="5" type="ORF">ERS852471_01418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265083.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35818">
        <property type="protein sequence ID" value="CUO35818"/>
        <property type="gene ID" value="ERS852471_01418"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="136"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="53307" checksum="F161A38826F91AB0" modified="2016-09-07" version="1">MKNEVLVKSLYRNSEEFFSKDIVISGWIRTLRASNAFGFIEVNDGSFFKNVQVVFDNNLENFKEVSKLPISSSIKVMGTLVATPEAKQPFEIQAKEVVIEGMSDSDYPLQKKRHTFEYLRTIAHLRPRSNAFSAVFRVRSVAAYAIHKFFQDQGFVYTNTPILTGSDCEGAGEMFRVSTLDLDNIPRTEDGKINYKEDFFGKETNLTVSGQLNAECYALAFRNVYTFGPTFRAENSNTARHAAEFWMVEPEIAFADLQDDMELAEAMLKYVIKYVMDECPEEMAFFNQFIEKGLLDKLNHIVSSDFGKVTYTEAVEMLKNCGKTFEYPVEWGIDLQTEHERYLTEEIFKRPVFVTDYPKDIKAFYMRLNDDGKTVAATDCLVPGIGEIIGGSQREERLDVLKARMAELNLKEEDYWWYLELRKYGETKHAGFGLGFERLIMYITGMSNIRDVIPFPRTTGQSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EH44</accession>
    <name>A0A174EH44_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">ileS</name>
        <name evidence="14" type="ORF">ERS852471_01447</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265134.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37021">
        <property type="protein sequence ID" value="CUO37021"/>
        <property type="gene ID" value="ERS852471_01447"/>
    </dbReference>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="676"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="590"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO37021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1036" mass="118727" checksum="3416C9A776D91F12" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIL6</accession>
    <name>A0A174EIL6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265103.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36279">
        <property type="protein sequence ID" value="CUO36279"/>
        <property type="gene ID" value="ERS852471_01429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="403" mass="46627" checksum="CC6AB39C5A502015" modified="2016-09-07" version="1">MASNNKLYRNFIILQEDERGYSNATGKTLSGYSKIEARAEKCKVSFYAQNLKKDTDDYHMVLICCKKDCKQIIDLGKIVISDTGKGEITKEYDASNIGGLGVSFDKICGAAVTKMKDGLPIYVMCGFLNSEQPSDNWKNYKVVKCNEHKPITMEKKPKKDDCKDDKKSDKKSEKKSDKCEHKKRDDDDKPVEISSISKDDNNDKVQEEPRAEEVNTEETKVEEEKVEEPKVEEVPYVPRENLRGKFEEYEEQIEAVKEFDPDASDIRGSIGEYFEAVANGFERCKGKYKEVKYTKWYKVPVNDLYEMCNMSNYNKYTLAYYPMLNYYPYIKKHGYFMLGYKCDSEGNLKYIVYGIPGKKDKDEQPYDGKTGFVTWVNDNDSDEVGCWLMFYDYKNSTVVVPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EK44</accession>
    <name>A0A174EK44_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ksgA</name>
        <name evidence="6" type="synonym">rsmA</name>
        <name evidence="9" type="ORF">ERS852471_01430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265105.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36320">
        <property type="protein sequence ID" value="CUO36320"/>
        <property type="gene ID" value="ERS852471_01430"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO36320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="31549" checksum="C59DED0CE2AB4273" modified="2016-09-07" version="1">MDIQDVKTAELVKKYNFKFTKSLGQNFLVDQSVPRDIVDGADVGPEDLVIEIGPGVGTLTAQLLKIAKRVVAIELDDTLIPILTEELGGYSNFSLIHNDALKVNFDEIIGDEKSVKLVANLPYYVTTPIIVKLLKEKHKFKSLTIMIQKEVAERMNAEPGNKDYGALTLLVQYYCNTKIVRKVPPACFIPRPKVDSIVIRLDKLDEPKVKVDNEKLFFDIIRNSFNMRRKTLWNGVKSIGPAKEKLEEAFEKAGVDPKRRGETLTIQEFATLSNCINEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELE7</accession>
    <name>A0A174ELE7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265192.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38634">
        <property type="protein sequence ID" value="CUO38634"/>
        <property type="gene ID" value="ERS852471_01480"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1980081at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO38634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10378" checksum="6255ECA8E8A5BEA9" modified="2016-09-07" version="1">MHKKIKTTITLSSHIKEFATEEAKSLGLDFSAYITVLIVEKLRGYNVINTMPAPISTNLDTSIKDIPVEPKEEIDEFQIDELDRLLSLTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELI1</accession>
    <name>A0A174ELI1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC C subunit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265152.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37446">
        <property type="protein sequence ID" value="CUO37446"/>
        <property type="gene ID" value="ERS852471_01457"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077602at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="83" mass="9992" checksum="977320A5F0B3EE86" modified="2016-09-07" version="1">MNYVYILRCNDDSLYTGWTNNLEKRLKAHSSGKGAKYTKARLPVDIVYYEEFEDKIDAMKREYEIKQLKRKEKLELINRKIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EY69</accession>
    <name>A0A174EY69_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265268.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41598">
        <property type="protein sequence ID" value="CUO41598"/>
        <property type="gene ID" value="ERS852471_01518"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1606823at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008589">
        <property type="entry name" value="MupG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043894">
        <property type="entry name" value="MupG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043797">
        <property type="entry name" value="MupG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38435">
        <property type="entry name" value="PTHR38435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05913">
        <property type="entry name" value="DUF871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19200">
        <property type="entry name" value="DUF871_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF871_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF871" evidence="1">
        <location>
            <begin position="247"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="364" mass="42006" checksum="64166711BB159F8D" modified="2016-09-07" version="1">MGKLGISIYQEKSTEEEILRYIDKAAENGFSRIFSCLLSVDESREEIVKKFKKTNEYAKSKGFEIIVDVSPAVFDKLGISYDNLSFFKEIGADGVRLDEGFGGFQEASMTFNPEGLKIEINMSNYTHYIDTIMDYMPNKEKLIACHNFYPHNYSGLNFDHFMRCTEKFNKLGLKTAAFITSQNENTFGPWPVTDGLPTLEMHRNLPVDVQAKHLIALDNINDIIISNCYPTDEELEAIGSMRKDMVTFDIVLNENTPEIERKILFEEMHFHRGDYSDNFLRSTQSRVKYKGHYFALFNAPEIIRRGDVIIESSEYGHYAGELQIALRDMVNSGKTNVVGHIRDEEVFILDYIKPWQRFCFKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZP3</accession>
    <name>A0A174EZP3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43453">
        <property type="protein sequence ID" value="CUO43453"/>
        <property type="gene ID" value="ERS852471_01556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO43453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16272" checksum="915CCB867ADCA1F3" modified="2016-09-07" version="1">MEEISNKVSQATGKIPLDLLSKDKECFKPLTSLNILSSYVYREKEYKVTKESMINYKGKKYSVLTKYIGLKLNVTETSDGNIIIYYNKDFILCLSLSGNKYNYKSGHMYKILKSDACKHLSDDQINDFIKENIALIYILLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2I1</accession>
    <name>A0A174F2I1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related function transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrR_2</name>
        <name evidence="5" type="ORF">ERS852471_01551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265332.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43138">
        <property type="protein sequence ID" value="CUO43138"/>
        <property type="gene ID" value="ERS852471_01551"/>
    </dbReference>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="99"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO43138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="36563" checksum="E7752F52240E8576" modified="2016-09-07" version="1">MSNKHIKNSKSNKTTRKSRNKKRLPLWSKIIIALVLIIILLFTIVFSLFHTTLNKMNNIEINKENLGVTSKEELQVYDNYKKIKNIALFGVDSENGVGRSDAIMIATVDPVHNKLKVTSIMRDSYVNIEGYEYDKINHAYAFGGPELSIKTLNQTFGLNIEDFVAVDFASLPVIIDILGGVEIDITEEEVELVPYVTYAGPQILDGEQTLAYSRIRYASGGDYQRTQRQRNVLSALFSKALSLPVSEYPSFINNMLPLIQTNLEATDILSLATKVAGMSNGVLEQERFPLDGYSWGENIDGVYYLAFDEIATKKQMMDYIFDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F426</accession>
    <name>A0A174F426_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neutral protease A, bacillolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">inlA</name>
        <name evidence="7" type="ORF">ERS852471_01587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265404.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44993">
        <property type="protein sequence ID" value="CUO44993"/>
        <property type="gene ID" value="ERS852471_01587"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2829at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021311" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="4">
        <location>
            <begin position="1291"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="4">
        <location>
            <begin position="1367"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1667" mass="184442" checksum="7A8D77BA9DD6EA03" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6N1</accession>
    <name>A0A174F6N1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265418.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45321">
        <property type="protein sequence ID" value="CUO45321"/>
        <property type="gene ID" value="ERS852471_01595"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2079533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="77" mass="9171" checksum="450920F66B547F56" modified="2016-09-07" version="1">MNNIIFKKERFDGNFNGTTPPIDGEYFTIKRGYKLRPSTLRRLHEIKAGHSDINIYMNTIIDNAINHYYEDVFLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJS0</accession>
    <name>A0A174FJS0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydiB</name>
        <name evidence="5" type="ORF">ERS852471_01682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265579.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50492">
        <property type="protein sequence ID" value="CUO50492"/>
        <property type="gene ID" value="ERS852471_01682"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO50492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="17360" checksum="F16FF32CFFF33C85" modified="2016-09-07" version="1">MIFSVNSVDQTTAIGLELGKILKSGDIVCLTGDLGTGKTHITKGIAKGLGIDDHITSPTFTIVNEYDSGRLKFYHFDVYRVSDPDEIYAIGFDDYIFSDGVSVIEWANYIEDILPNEYLHIHIEKDLDKGENFRNITLKPYGERYDYIKELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTL0</accession>
    <name>A0A174FTL0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein, CotS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cotI_2</name>
        <name evidence="2" type="ORF">ERS852471_01747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265695.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53584">
        <property type="protein sequence ID" value="CUO53584"/>
        <property type="gene ID" value="ERS852471_01747"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="331" mass="39686" checksum="28E6913C60CC342A" modified="2016-09-07" version="1">MDTINISRVIENNYDIDIRYIEQIKNAYKIDSKDRGYCVKVIGYKFPHFYFILSAMKHLQKKGFKTVPSIIKTKNNMDFIKLGDKYAYLTEWIPSRISNYDNPIELAKVAEKIGELHTCSTGFILDRRMTPRYGWNKWISTFSTRCDEMLDFAHRISQKAKKSEFDRLYLEHLDEEIERGIASINGLKKSNYFYLMNKEIMKCGFCHHDLAHHNILVDRNGELNIIDFDYCILDSHIHDLSSLMIRAMKDGKWSKEKADLILNNYSISNEVKDEELNIMKYFIKFPQVFWQVGIQYYWEQQLWGEDFFVSKLKKYLDDREEREEFLEEYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYT3</accession>
    <name>A0A174FYT3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265738.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55452">
        <property type="protein sequence ID" value="CUO55452"/>
        <property type="gene ID" value="ERS852471_01768"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1823150at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO55452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="12865" checksum="DE5830AF52985565" modified="2016-09-07" version="1">MKAEKIFYQFYKAIEKCTAIGTDKYSYKKSNCKKVKIFSYEDRRNLIKVTSLLCDFLEEIYSEIVFIKDIKTKHIQNFFIEKAKYCTKSTLKNYYYCIRKLEKMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GC32</accession>
    <name>A0A174GC32_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN_2</name>
        <name evidence="8" type="synonym">murJ</name>
        <name evidence="10" type="ORF">ERS852471_01864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265920.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60003">
        <property type="protein sequence ID" value="CUO60003"/>
        <property type="gene ID" value="ERS852471_01864"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO60003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="512" mass="56103" checksum="88ED38B29D38AD7F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDK9</accession>
    <name>A0A174GDK9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265885.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59228">
        <property type="protein sequence ID" value="CUO59228"/>
        <property type="gene ID" value="ERS852471_01846"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883872at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO59228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="26382" checksum="B6D275DEC962A4C5" modified="2016-09-07" version="1">MKKIISQLVVAIVCAILGFLLTYQFKMLRLQEDAKSTAQNQDILYQIEALKKEKEELSETNKTLSEEIKRLEEVAAEEGALENEIKKQLDNARMHLGLLDVKGSGIVITITPKTTIFGENTTDSTVGISEEELIHIINLLWYSRAEAISVNDIRITPQTGIKTSGRSISIGTVGLVDPKSKIVIKAIGDKAKLNVGVSYGNSLAYGALKNYSVETKTSDDIVINKTTQSLRNEYIKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GF36</accession>
    <name>A0A174GF36_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraW</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="7" type="ORF">ERS852471_01854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265901.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59586">
        <property type="protein sequence ID" value="CUO59586"/>
        <property type="gene ID" value="ERS852471_01854"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO59586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="35109" checksum="02A4AE0172F5B66C" modified="2016-09-07" version="1">MEFNHVSVLLNECLDALNIKEDGIYVDGTLGGAGHSSEILKRLSENGRLIGIDQDTDALKAAAIRLQNFNNVTFVHNNFYNIKQILDDLDIEEVDGILMDLGVSSYQLDTGERGFSYMKDAPLDMRMNRENELSAYEVVNTYSEDELYRIIRDYGEEKFAKRIATFIVNAREEKNIETTLELVEIIKNAIPAKARREGPHPAKRTFQAIRIEVNSELSILNRAIEDGVSKLSKGGRMAIITFHSLEDRIVKNKFRDLAVACRCPKEFPICVCGEKAKVKVISRKAIDPSKEEVEMNPRSRSAKLRVIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKG4</accession>
    <name>A0A174GKG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:dicarboxylate symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltP_2</name>
        <name evidence="8" type="ORF">ERS852471_01915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO62843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266006.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62843">
        <property type="protein sequence ID" value="CUO62843"/>
        <property type="gene ID" value="ERS852471_01915"/>
    </dbReference>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO62843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="457" mass="48527" checksum="4A10EA73E2F9EC25" modified="2016-09-07" version="1">MNSKTKNNNSNKLAIHMAIALIIGLIAGTGFLLLRENLIASGNAGLWQTINKILFQDISVEGANDAIGIFYILGQLFVNSLQLVIVPMVFTSIALAMCRITDTKKLGRISYKTILGFLATSVFALVLAGIFGITAHKLGFFNVSIENIASQTGSTGSNPLLVLVQTIPNNIASVFTQNGRILSIVFLAVVTGLCLNKLEDKIQVLKKLLEDVNNIITLFLSFVITKFGPIAIFVLITRTFAIYGVEHLKPALAYVVTVIVALLIFLVFGYALFILIAARLNPFIFVKKISKVALFGFSTSSSASSLPLNTKTTVEELGVSEEIASFTLPLGMTINMNGTAIMQVIAAIFIASSAGYDITIGNIAIISLLALIASIGTPAAPGAGAIILFTVLTGMGYQNDAALLAYSLILAINRPVEMLVTSLNVVGDAATAVVVAKSENALDEDIYNSTEAVLENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLH9</accession>
    <name>A0A174GLH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO62018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265994.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62018">
        <property type="protein sequence ID" value="CUO62018"/>
        <property type="gene ID" value="ERS852471_01914"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2059823at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO62018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="21536" checksum="631E8D31B0E25EE0" modified="2016-09-07" version="1">MNNLYPISKENFKKLINIRFNNISDGLDNFSNGILECNDKLLSFTEKENRFLKFFKDTLLLNSGHIIIDFYLKNLNGEEILHLLEALDHNNKIILLQELKNLKDDSVYFTLDNNNLMDFITILNTRALFFCTIYLNTFPFTIWGNYDLKFPVFFSDINTLNIYKNLAEKNGLSINSINIKRGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLS3</accession>
    <name>A0A174GLS3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Activator of (R)-2-hydroxyglutaryl-CoA dehydratase HgdC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hgdC2</name>
        <name evidence="6" type="ORF">ERS852471_01910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265990.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61850">
        <property type="protein sequence ID" value="CUO61850"/>
        <property type="gene ID" value="ERS852471_01910"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8032at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="319"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="5">
        <location>
            <begin position="670"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1421" mass="159025" checksum="A1B79FE2BBB12A67" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXV3</accession>
    <name>A0A174GXV3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombination factor protein RarA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266205.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67572">
        <property type="protein sequence ID" value="CUO67572"/>
        <property type="gene ID" value="ERS852471_02017"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1482912at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MgsA_C" evidence="1">
        <location>
            <begin position="53"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="200" mass="23230" checksum="8A9FA6D3B7C8C5DB" modified="2016-09-07" version="1">MSYSMWAEIKTRNGFAADEIISCYQKAVRRSMVEEACEYAYELYITSPQLLDKLWRRILTISVEDIGFGNLDAAVQVNALNEMRKNYPYDDGDQPMYFIHATRILAESTKDRSSDYLKNIVIKSFAMGKKVEVMDVALDKHTKRGQEMGRGSKHFFEEGTKVIPQLKIDNDYRERYGKILEVYKPEEAVENAFVYGKDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0F9</accession>
    <name>A0A174H0F9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 1</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bglH_3</name>
        <name evidence="6" type="ORF">ERS852471_02022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266216.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67751">
        <property type="protein sequence ID" value="CUO67751"/>
        <property type="gene ID" value="ERS852471_02022"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO67751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="474" mass="54620" checksum="757B4119E7D5290F" modified="2016-09-07" version="1">MGFPSDFLWGGATAANQCEGAYDVDGRGLANVDVQPHGRERFLVSKGDRHMLELEEGYYYPALEAIDFYHNYKEDIKLFAEMGFKVFRMSIGWSRIFPNGDETKPNELGLQFYENVFKECKKYNIEPLVTITHFDCPIHLTKVYGGWRSRDMVTFYERLVTVLFNRYNGLVKYWLTFNEINMLLHLPFTGAGILLEEGENKDQLLFTAAHHQLIASALATKIAHEVDPEMKIGCMLAAGNTYPNTPNPNDIWKSMNKDRENYFFIDVQARGAYPRYALKEMERKGVVLPLEEGDLQLLKENTVDFVSFSYYSSRLTSADPEVNKYTEGNVFPTLRNPYLKASEWGWQIDPLGLRITLNSIYDRYQKPMFIVENGLGAKDELIDGTVNDDYRIEYLREYIKAMKDAIDIDGVELMGYTAWGCIDLISASTGEMSKRYGFIYVDRDDLGNGTLKRYKKKSFNWYKKVIESNGEDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4A7</accession>
    <name>A0A174H4A7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266222.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67859">
        <property type="protein sequence ID" value="CUO67859"/>
        <property type="gene ID" value="ERS852471_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="28881" checksum="63ACE8413ADBADB3" modified="2016-09-07" version="1">MLMNKINNILNTTYTNDTYHSICKYIKDNILEIQNMSIDEIAEGCFVSKSMISKFTKKLGYETFKDFKYDCEIHCDLIKYMPTTEYKSNNLRENVIETMDLITNAFRNAANKIDYVALDSLIEDIDKCSCVVAVGHGASKNVCESLQFYLDYMNKPVMIADTDFTRDVLVEENSIILLISANGNILKHDRRLINKINSLKQKKWLLTCNSNIDTNTIDNIVVIPSKDKAINDMLTMFMVKVIANRLKHIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6L9</accession>
    <name>A0A174H6L9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="9">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">selO</name>
        <name evidence="10" type="ORF">ERS852471_02077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266304.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69831">
        <property type="protein sequence ID" value="CUO69831"/>
        <property type="gene ID" value="ERS852471_02077"/>
    </dbReference>
    <dbReference type="OrthoDB" id="130048at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="483" mass="54870" checksum="9EB60FFA6104AA50" modified="2016-09-07" version="1">MRKIKLENTYIKLPEVFYSKQKPSHVPKPKLVAFNYSLAEELGLDVKYLESSEGVEILSGNKVLEGTTPIAQAYAGHQFGYFTMLGDGRAVLLGEFITPKNERLDIQLKGSGETPYSRGGDGKASLGPMLREFIISEAMYGLGIPTTRSLAVVETGETVIRERLLPGAVLTRIASSHIRVGTFQYIASYGSIEDLRALADYTIERHYKELVNEENKYLKFLKEVIKKQADLISKWQLVGFIHGVMNTDNVTISGETIDYGPCAFMDIYNPSTVFSSIDRSGRYAYGNQPNIGAWNLARFAESLLPLLSDDKDEAINIAQETISEYPKIFKKKWLAGMRGKLGLFNEEVEDEALINELLTIMEKNKADFTNTFRALTMNKVEDTGMVGKEEFDRWYERWQQRLTRQDKTKEEVYKLMKSNNPSIIPRNHRVEEALEAAVKNSDYTVMDKLLEVLKTPYDYSEDKEEYVSLPKESKVPYKTYCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H920</accession>
    <name>A0A174H920_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ugpQ_3</name>
        <name evidence="3" type="ORF">ERS852471_02107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266367.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71442">
        <property type="protein sequence ID" value="CUO71442"/>
        <property type="gene ID" value="ERS852471_02107"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018476">
        <property type="entry name" value="GlyceroP-diester-Pdiesterase_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10110">
        <property type="entry name" value="GPDPase_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="348"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO71442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="596" mass="68439" checksum="A9076CBC687772CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HC34</accession>
    <name>A0A174HC34_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70445">
        <property type="protein sequence ID" value="CUO70445"/>
        <property type="gene ID" value="ERS852471_02093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="34117" checksum="6B72BC4A81794BD6" modified="2016-09-07" version="1">MRNVWIVNMLQQAFGETIRFNNGVFGYSMLYPYTDNYLDNIEIGLEEKISFNKRFTKRLNGEKVMPLNKHEDKVYNLVSCIESEFKREKFNGVYDSLLLIQEGQKLSLNQQEEESIPYEKDILGISIDKGGASVIADGNLIRGTMSEEEERFAWGYGFLLQLGDDLQDIKADKEKKHMTIMSQLAGKYHLDKIVNKLINLTIYVVDNAKCFVCKNPNELKELIKNNCNYMVLFAIIDNKEYFSKEYINEINDYLPFTIEFCGGIKQKINDKFKKLKKEYHGVAVEDILMEFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDW6</accession>
    <name>A0A174HDW6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ORF">ERS852471_02101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71209">
        <property type="protein sequence ID" value="CUO71209"/>
        <property type="gene ID" value="ERS852471_02101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO71209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="21770" checksum="AC1823FDB219BB9C" modified="2016-09-07" version="1">MMDDLLFNVYERAEKGNKVRKRGEIPCVIYGDETHKAISAKMTKKEMYRLLGYPKNSIISLNLNGDIKTCIVKETQKDIYGKVAHIDFQTIRKGEVVKLGIPITFVGQDALAAKSLLLETFVSEVELQGEPNKFPPHIEVNVSNLQAGNRIYIRDLPIPKDVVVEENEDLEIAKIDSIIYESDSDDNNTTTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFR8</accession>
    <name>A0A174HFR8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73704">
        <property type="protein sequence ID" value="CUO73704"/>
        <property type="gene ID" value="ERS852471_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="30" mass="3315" checksum="A7DEA7CDF94176B0" modified="2016-09-07" version="1">MSILLTITLGGVIYTLVEMTYNCLNNITIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJJ5</accession>
    <name>A0A174HJJ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dmsB_1</name>
        <name evidence="6" type="ORF">ERS852471_02150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266445.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73159">
        <property type="protein sequence ID" value="CUO73159"/>
        <property type="gene ID" value="ERS852471_02150"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="134" mass="14831" checksum="3B0E02A079731DB0" modified="2016-09-07" version="1">MKRIKIDRSKCVGCLTCTTACIVSHGSEDTRSRITIDSNGKYAPIFCRHCDKPECVYTCMTGAMSKDRETGKVTYDKNKCASCYMCIMACPYGVLKADSRTHKEIMKCDGCKEKGSPQCVAKCPMSAITLEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMX8</accession>
    <name>A0A174HMX8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">paaH</name>
        <name evidence="7" type="ORF">ERS852471_02240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; butanoate metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266595.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76312">
        <property type="protein sequence ID" value="CUO76312"/>
        <property type="gene ID" value="ERS852471_02240"/>
    </dbReference>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="UniPathway" id="UPA00863"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="5">
        <location>
            <begin position="184"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO76312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="30697" checksum="335EAAC93BD6B675" modified="2016-09-07" version="1">MEKIFVLGAGTMGAGIVQAFAQKGYEVIVRDIKDEFVERGISVINKGLSKQVAKGKITEEVKEEILSRISGTTDMNLAADCDLVIEAAIENMKIKKEIFAELDKICKPEAVLASNTSSLSITEVASATSRPDKVIGMHFFNPAPVMKLVEIIRGMATSQETFDVVKEAALAIGKEPVEVKEAPGFVVNRILIPMINEASFILQEGIASVEDIDTAMKYGANHPMGPLALGDLIGLDVCLAIMDVLYNETGDNKYRASNVLRKYVRAGWLGRKTGKGFYDYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HR17</accession>
    <name>A0A174HR17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cmpR_1</name>
        <name evidence="3" type="ORF">ERS852471_02272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266657.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77422">
        <property type="protein sequence ID" value="CUO77422"/>
        <property type="gene ID" value="ERS852471_02272"/>
    </dbReference>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO77422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="32920" checksum="8D8F0FA53889F36B" modified="2016-09-07" version="1">MNIRHLKIFITVADCGKMSEAAERLFISQPSVSQAIREIEDYYGVKLFERLSKKLYITESGELLLRYARHIVSSFDEMEADLKNSGQNICLKIGSTVTVGTCILNDIISKFEEENKDISTKIIVNNTNVIESMLLHSNLDIGIVEGIVNNKDLVRIPICSDKLVLVSGKKHNFYYKDEINIEELSGQDMIFREKGSGAREIFDSILEENNIAVNEKWNSTNTEAIKNAVIGGQGLGILSTLIIQDEIKDGTLHIIPIENIDISREICVVYHKDKFISNHLKRLIESIQYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRP1</accession>
    <name>A0A174HRP1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretory pathway, component PulF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">epsF_2</name>
        <name evidence="9" type="ORF">ERS852471_02226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266565.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75750">
        <property type="protein sequence ID" value="CUO75750"/>
        <property type="gene ID" value="ERS852471_02226"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="67"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO75750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="400" mass="44795" checksum="9961E79F540AD243" modified="2016-09-07" version="1">MPIYVYEGKTLNGSVEKGKAEYLNINAARESLRGKGIFINSIKEETASMNIEFNFKKNIPYQDLAIFCRQLHFGLAAGIPILRAIGMIKDQIEHKKLKSILTNVYEEIQKGSALSEVLGQHKEIPYMLTAMVEVGEATGNIDQIMGEMAEYYDKQHRQKKTIDAALTYPKFLLAFSICIVIGLVTFVVPTFVDSILSAGQELPLPTQALIAISDFIKNNFLLLTVVAIGLYIIKLTLIDTNPKVQYEKDRFLVTNKKLSPITQQIFTARFARTFALLVQGGMSVMNGLEIAGNAVDNRYIKKMIEECNYMIQKGQGIGDSLETRKIFPKMMTQMMKVGEETGSIDDILKKTSEYYEIEAEFAIKKLTALIEPVMIVFLAFIVGFVVISLAMPMFQVMGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1U4</accession>
    <name>A0A174I1U4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, FAD-binding</fullName>
            <ecNumber evidence="5">1.21.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvdP_2</name>
        <name evidence="5" type="ORF">ERS852471_02322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.21.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266731.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79547">
        <property type="protein sequence ID" value="CUO79547"/>
        <property type="gene ID" value="ERS852471_02322"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="440" mass="50360" checksum="ED84D221C244E177" modified="2016-09-07" version="1">MIEVITPSSNYYDDARQEWNKSIDKYPTAIAYCKTFDDVKKAVLFARKNRFKLRIRSGGNNYEGFSIDDGLFIIDISNLNRININYENNTFTAEGGALLGQLYNFLGSNGYPFPGGSSPTVGIAALTLGGGWGYSSRYLGLSCDSLVEVKLVNYEGSLLTANKDTNSDLFWALKGCGGGNFGIVVSLTFNLPPKVDLVTTFNIYYSNINKDNQIKFLDTWQHWITNSPDKINMKSSIANSAYDGYYIYCTGLLYGTPNELMDILSPFMNIEGCNLTYENVSFLQSTEIIGSFYNQYERFTSYSRFVSREYSYDEISKLVDIINEQRPEGSQTTLLNLYGLGGKVSKIDKSDTAFYYRNSNYIIAIESDFEDNEYKAENTKWIEEKSRFIYNITDGSYINFPYYPLDNYLYEYYGDNSIYLQRINKKYDPFNTFDFQQGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4B1</accession>
    <name>A0A174I4B1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA replication protein DnaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaC_4</name>
        <name evidence="3" type="ORF">ERS852471_02336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266757.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80120">
        <property type="protein sequence ID" value="CUO80120"/>
        <property type="gene ID" value="ERS852471_02336"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="2">
        <location>
            <begin position="177"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO80120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="329" mass="38442" checksum="1DBB68ADDD1CE6FD" modified="2016-09-07" version="1">MIKGYQEKLMNIYEKIREDENRNLKNRKNEILQKAPEIIELDNTIQKLSLALPMAILKGASESDLDNIKADIQELRKQKYELLTSYGYPTDYLTLHYQCPKCQDTGYIGTKRCSCFKTKLVNLYYETSKLSNNLATCNFNNFDIRLFSSENSGNYKNSQRKNMEKIYEFVRGNYLANFDTDNTNLLFYGESGNGKTFLSWCIAKELLDKGYLVIYKTSNDLIRDLREITFNNNYVLEDLLINCDLLIIDDLGAEQVTDFSTNELFNLINKKLLNNKKMIISTNLNLPDIEKSYTTRVYSRLVGNFTFFKFYGNDVRIKLNLARMRSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I598</accession>
    <name>A0A174I598_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266842.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82344">
        <property type="protein sequence ID" value="CUO82344"/>
        <property type="gene ID" value="ERS852471_02388"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO82344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="68" mass="8234" checksum="EB137F2D613DE563" modified="2016-09-07" version="1">MPFVDKRENETRVFKDEDFGGIQMISYMKSSRMPIKEIKRFMDMCLVGDDTLEERLQVFYYRKKAVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I809</accession>
    <name>A0A174I809_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83263">
        <property type="protein sequence ID" value="CUO83263"/>
        <property type="gene ID" value="ERS852471_02410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO83263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="33" mass="4044" checksum="B241F73C4542D560" modified="2016-09-07" version="1">MKLKKMVVEISDEDIINFMKLQNKVIVYVFKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IK33</accession>
    <name>A0A174IK33_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ORF">ERS852471_02513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267052.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87673">
        <property type="protein sequence ID" value="CUO87673"/>
        <property type="gene ID" value="ERS852471_02513"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO87673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="425" mass="46613" checksum="876C4701D8D1D891" modified="2016-09-07" version="1">MLSTLRNAWKVPELRKKFLWTIFLVAIFRIGIHIPVPGIDTSYLTQVTESGGLLSFYNLISGGALKNFSIFALAVSPYINASIIVQLLTIAIPSLEQLSKEGEEGRKKIQSITRYLSIGIGFVLAMGIFTMISSQGAATGLNTAEKAVVLISLVVGSTFCMWLGDQITQRGFGNGVSILIFVNIVSQLPMTLMSLFTLKEAGQVGIVEITIFLVAVVALLAISIFFSLAERRVPVQYAGKAVGSKVMKGQSTHIPLSIIGSAVIAIIFAMSVMMFPETIANFFPGKSWSTWILHSPYSIFNKETWMYPVFYAAFTIFFTWFYTQITFKPDEMAENLHKSAGFIPGVRPGAPTEKYFEKLLTKVSLIGGVFAAVLAVLPTIVNNYTAFKGIQFGGTSVLILIGVGLDFSRQLDSQLVMRHYQGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IU30</accession>
    <name>A0A174IU30_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267124.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89961">
        <property type="protein sequence ID" value="CUO89961"/>
        <property type="gene ID" value="ERS852471_02555"/>
    </dbReference>
    <dbReference type="OrthoDB" id="638193at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024591" evidence="1">
        <location>
            <begin position="26"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO89961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="42083" checksum="9CF5BA5A193B42F2" modified="2016-09-07" version="1">MKIKRSILCFIIAAIAVLSVGCSSRDNDDKDLSSSIADALNQQNGTSSNFFWENGMTDDTIAIIVNRYTEEQYKSLGETTKVVLQDESNEKFLIVSAEDNTNVEIWSVDYENDKFVEKELECEMTAIKKNTVVEVQASRSEGTPTYKIKFSNSKGELEYYLTENLKDGNPNIEYLTIDIQSDSNDENKTELENNEASNKLTIGMFIPNGEYEIKYEASDLVSNNDYIIGNGSAYQVVGTNGKGPYVNVYEVKENGLYRVFTGDLTEDEMANIETINYLDKRDNTEEILLLNEPIAVGTRWEDKEIVEVGENLKLGELSLEGAYVKTWEKETINDIEYVKVYYYSEGLGCVQHRVLEGETVVEYSIATEIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVJ6</accession>
    <name>A0A174IVJ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate butyryltransferase</fullName>
            <ecNumber evidence="3">2.3.1.19</ecNumber>
            <ecNumber evidence="3">2.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptb</name>
        <name evidence="3" type="ORF">ERS852471_02543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.19" evidence="3"/>
    <dbReference type="EC" id="2.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267101.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88919">
        <property type="protein sequence ID" value="CUO88919"/>
        <property type="gene ID" value="ERS852471_02543"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050182">
        <property type="term" value="F:phosphate butyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014079">
        <property type="entry name" value="Phosphate_butyryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02706">
        <property type="entry name" value="P_butyryltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="77"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="32196" checksum="3850564E7EEB46A1" modified="2016-09-07" version="1">MGKNFEELFSQLKAVSTKKLAVAVAQDEPVLEAVNLAKDRGVVDSILVGDKAKIEKIAKNIDMDLSKFEIINEEDPQKATLKAMELVSTGQADMVMKGLIDTATFLRGVLNKEVGLRTGKLMSHVAVFEIDGIDRLILLTDAAFNTYPDIKAKAQIINNSVMVAKACGIEYPKVAPICAVEVVNTDMPATVDASLLSKMNDRGQIKGCIVDGPLALDNALSEEAAHHKGIKGEVAGKADILLFPNIEAANVMYKALTYTAKTRNGGILVGTSAPVILTSRADSCETKVNSIALAALVAESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IZQ4</accession>
    <name>A0A174IZQ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">btr_3</name>
        <name evidence="7" type="ORF">ERS852471_02622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO92904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267249.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92904">
        <property type="protein sequence ID" value="CUO92904"/>
        <property type="gene ID" value="ERS852471_02622"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO92904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="686" mass="81306" checksum="0A20A3DE785E8769" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J337</accession>
    <name>A0A174J337_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92267">
        <property type="protein sequence ID" value="CUO92267"/>
        <property type="gene ID" value="ERS852471_02616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO92267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="117" mass="13683" checksum="D0E40270B52D27DA" modified="2016-09-07" version="1">MFSDFSKENGFSLIADEFKRDLKDYNKMVFIASDPSIGEITDKYAEKYLKWFEKIGINFENKVTLDNFNDELKELSYKYLIYGMCDESAIIVRDDKCTYYGDIYVLKNGTAEKVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J3I7</accession>
    <name>A0A174J3I7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="8">3.6.3.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ugpC_2</name>
        <name evidence="8" type="ORF">ERS852471_02657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.20" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267307.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94193">
        <property type="protein sequence ID" value="CUO94193"/>
        <property type="gene ID" value="ERS852471_02657"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO94193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="38991" checksum="194384A1D54C1E39" modified="2016-09-07" version="1">MGIKLDKLVVKFGDFTAINNVTLEIPKGKLVSLLGPSGSGKSTTLFTISGIHKVHSGKIYFGDRDVTGLEPEKLGIGLVFQNYALYPHMTVRENIMFPLKNLKWDKKKAEDRVIEVAKIVKIDALLDRKPAQLSGGQQQRVAIARAIAKKPDILLLDEPLSNLDTKLRVETRQEIRRIQKETGVTAIFVTHDQEEAMSISDEIVLMKDGAIQQVSTPSEIYLNPVNKFVASFIGSPEMNFIDVDVIDGEAFLDNHKISNLPENKKKVTLGFRAEDLELCDDGLEVEVITVEILGRERLLTLKHRENTYKMLVENTCDIAEGEKIRIRPKEGKAYVFDLDSEEFLKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J4Y2</accession>
    <name>A0A174J4Y2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92220">
        <property type="protein sequence ID" value="CUO92220"/>
        <property type="gene ID" value="ERS852471_02615"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO92220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="29810" checksum="87F5DDDB03C816BA" modified="2016-09-07" version="1">MIFDTHMHTIFSSDSKMSISEVINTSKSLNLGVCLTEHMDLDYPEENEFKCDIPRYLETYSNYRSDSLLLGIEIGMTQNTLLENEATSNKYDFDYILGSIHTVDGLDIYNTFHNNKLPSDDFYKRYYENMLYCVENYNNFDSLGHIDYLFRYAPFPNNEININPYKEIVEAIFLNLIKKDKAIEINTRRLSNPASLQALLETYKFYKELGGRYVTIGSDAHTPSAIGNNIKEALMLAEQLSLKPIYYKSRKINYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J9B2</accession>
    <name>A0A174J9B2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Ubiquinone) 24 kDa subunit</fullName>
            <ecNumber evidence="7">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoE</name>
        <name evidence="7" type="ORF">ERS852471_02663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267319.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94477">
        <property type="protein sequence ID" value="CUO94477"/>
        <property type="gene ID" value="ERS852471_02663"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028431">
        <property type="entry name" value="NADP_DH_HndA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43342:SF2">
        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO94477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="162" mass="18163" checksum="B03E5AEED6BD3F06" modified="2016-09-07" version="1">MCISNVNKEKFNELGDYIEKNDLKENDLIAVLHKAQELFGYLGEEVQLFVSEKLGVPVSKVYGVITFYSFFTTEPKGKYVINVCAGTACFVRGAGEIIEEFKKNLNIEVGETTEDGLFTLDTLRCVGACGLAPVVMVNNRVYGHFTKKNVEEVINEHKRLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JI18</accession>
    <name>A0A174JI18_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267438.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97517">
        <property type="protein sequence ID" value="CUO97517"/>
        <property type="gene ID" value="ERS852471_02727"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1124669at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="480"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="689" mass="77704" checksum="1EDE7D8A29C4BB98" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JIH8</accession>
    <name>A0A174JIH8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoD</name>
        <name evidence="6" type="synonym">sigA</name>
        <name evidence="9" type="ORF">ERS852471_02739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267462.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98006">
        <property type="protein sequence ID" value="CUO98006"/>
        <property type="gene ID" value="ERS852471_02739"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="303"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO98006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="368" mass="42241" checksum="9D77CE121557C4FA" modified="2016-09-07" version="1">MEEKTKAASNKKKDIQDRNERMSIVKNLLDKGKKAGVLTYKEILDEIDHIDLEPEQIEKIYEVLESMGIEVQGQAAEVEVVEEDLDLTIPEGIAIDDPVRMYLKEIGKVPLLSSEEEMELAKRIEEGDQYAKKKLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNLGLIKAVEKFDFRKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVQRQLLQELGRDPYPEEISKVMDLPVDKVREIQKIAQEPVSLETPIGEEEDSHLGDFIPDDDAPAPAEAAAFTMLKEQLINVLDTLTPREEKVLRLRFGLDDGRARTLEEVGKEFNVTRERIRQIEAKALRKLRHPSRSKKLKDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JK39</accession>
    <name>A0A174JK39_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-like transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrR_3</name>
        <name evidence="5" type="ORF">ERS852471_02782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267532.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00073">
        <property type="protein sequence ID" value="CUP00073"/>
        <property type="gene ID" value="ERS852471_02782"/>
    </dbReference>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="89"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP00073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="479" mass="53612" checksum="B64ED11DA690DF2C" modified="2016-09-07" version="1">MSEDNTVKRRQNKDKRKKWSNRKKIIVSTISVLIAIIMLLLGGYLYVRGKIYSNDNSNSIKDSEYQEVPGITNVLLIGTDARTLDEQSRSDSIIIATLDNNTKKIKLTSLFRDTLVNIPGYGEQKLNAAYALGGPSLLLETINDTYDIHIDKYVVINFWGFEAIIDQIGGIEVDVKDYQLEELNKYIGESTGGNDCPVTQTGLQVLNGKQALSYARIRYNTGDEFERTARQQEVLMKVAEKLRETKPSKYLGIMNKMLDYIKTNIDPLQALNMAYTIYKFPSLVTEQLQIPTPELAEGRLYKDLGWVFLMDGEQNAQILHDFIYNDKIPNPDEFDYYSLYQKLAQYAADEDIYNSQNGINPEDYENIDQDLPKQEEITKPPVEEKPIEQPGGSTEQPSEGTEQPGGSTEQPGGGTEQPSEGTEQPGGSTEQPGEGTEKPDEGIEKPGEGTEQPVDGTDKPVNATDPVQPEDISQEQPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JLK6</accession>
    <name>A0A174JLK6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bcl-2 family protein</fullName>
            <ecNumber evidence="1">2.1.1.217</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmK</name>
        <name evidence="1" type="ORF">ERS852471_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.217" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267463.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98055">
        <property type="protein sequence ID" value="CUO98055"/>
        <property type="gene ID" value="ERS852471_02740"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1627266at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006901">
        <property type="entry name" value="TrmK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04816">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018637">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO98055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="26331" checksum="4CC2B971AA8D12BD" modified="2016-09-07" version="1">MDKSKRIEFIVSNLEKVTTLADIGTDHGYVPLLALRNGICEKAIACDINKDPLAKGKLNAILEGIDDKIDFRLGNGFEPLEVNEVEEVVIAGMGGNLIRDIIEKDLNKAASCNYLVLIPAQNPEVLREYLYKNDFEIIKEDLCFDEGIYYELFMVKKAEGHATELDSIYYEISPILLRQKHPLMKDYVDYKIEEYNKILGFIKDDSESALKRKSEVSEKIEILNRMKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JRU3</accession>
    <name>A0A174JRU3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">puuR_2</name>
        <name evidence="2" type="ORF">ERS852471_02777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267522.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99885">
        <property type="protein sequence ID" value="CUO99885"/>
        <property type="gene ID" value="ERS852471_02777"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO99885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="179" mass="20698" checksum="7D2BBBB57129E5A2" modified="2016-09-07" version="1">MEIGEKIKRMRIEKGLTQEELANRCELSKGFISQLENDLTSPSIATLIDILEILGTNLKEFFSDDKEEKITYTYEDMFETENEELKYSLMWLVPNAQKNEMEPIMITLEPNGQYIEEEPHEGEEFGYVLSGSITLHLGKKKFKVKKGESFYFKPRSNHYISNSGKTPAKVIWISTPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K198</accession>
    <name>A0A174K198_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="9">Holo-ACP synthase</shortName>
            <ecNumber evidence="9">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">acpS</name>
        <name evidence="11" type="ORF">ERS852471_02842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267649.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03225">
        <property type="protein sequence ID" value="CUP03225"/>
        <property type="gene ID" value="ERS852471_02842"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="10">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP03225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="13998" checksum="D70CB6B9FDBD0271" modified="2016-09-07" version="1">MILGVGTDIIEIERIKKAIERTPKFLEKTFTEKEIELFKSKSMKLESIAGNFAAKEAISKAIGRGFRGFSFNDLEVLRDELGKPIVNISNKVKEFLEYEEVIFHISISHNKSCAIAFVTMEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K394</accession>
    <name>A0A174K394_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate-transporting ATPase</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
            <ecNumber evidence="5">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD_2</name>
        <name evidence="5" type="ORF">ERS852471_02890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EC" id="3.6.3.28" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267737.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05321">
        <property type="protein sequence ID" value="CUP05321"/>
        <property type="gene ID" value="ERS852471_02890"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="234" mass="25853" checksum="E6C1FE7ED2499672" modified="2016-09-07" version="1">MSNYIEFKDVKKVYKMGEVEIEALSGVNFSVDKGEFVVVAGASGAGKSTILNILGGMDTVSSGKVIVDNNEVSKYSQKELVTYRRDDIGFVFQFYNLVQNLTVRENVELAIQICKNPLDIDKVLDAVGLSERKNNFPSQLSGGEQQRVAIARALAKNPKLLLCDEPTGALDYNTGKAILKLLQDTCREQGMTVIIITHNLALTPMGDKIIEIKSGKVKRMSINENPVPVERIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9C0</accession>
    <name>A0A174K9C0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4474 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267870.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08664">
        <property type="protein sequence ID" value="CUP08664"/>
        <property type="gene ID" value="ERS852471_02965"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1638076at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029322">
        <property type="entry name" value="DUF4474"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14751">
        <property type="entry name" value="DUF4474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4474" evidence="2">
        <location>
            <begin position="47"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP08664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="37051" checksum="2E22554E741C9391" modified="2016-09-07" version="1">MDNSIILAICMSVLSIMILLLFWRWRRRKAAIEKVKGRTDEEKLKDINDALEIYGFLFDIEQDIVYSSLHPPQRKLGYCSLYDELAPSLNMIIDCEPIYFEYGGKRWLIEFWKGQYGMTTGGEVGVYATGKKDVDIPDVFTGTFYESVSDKYLLQMKYILKKNDNQIIEREERHWWLTGFDVGLFSKPEELSLKIEITFPYLDMQRAFIDGLYYAGYKANEIKINGRMVKLVFTSPKTKQPQKYSKFMVGFIQLLNRFYCNLFNWVTKDFTRAIDKIDFLRSYYPILFKLLANDKKAKKLENLYRDIQDFLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KCZ7</accession>
    <name>A0A174KCZ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267918.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09883">
        <property type="protein sequence ID" value="CUP09883"/>
        <property type="gene ID" value="ERS852471_02985"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="176" mass="19652" checksum="7B8225F18AB0DAA8" modified="2016-09-07" version="1">MEINIREELEKDYEVVERLTEEAFKNAVHSDGTEHLLVNRLRKSDDFIKELSLVAEDNGKVIAHLMLTKAKINNGDMSVETLALAPVSVIPEYQGKGIGSKLINVALESARRLGYKSVIVLGHDKYYPKFGFVPASKYGIKAPFDVPDEAFMVKELNDGSLIGVSGIVEYTKEFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KG61</accession>
    <name>A0A174KG61_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_03012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267967.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10902">
        <property type="protein sequence ID" value="CUP10902"/>
        <property type="gene ID" value="ERS852471_03012"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="331"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="577" mass="63502" checksum="E382206C61150508" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKS1</accession>
    <name>A0A174KKS1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_13</name>
        <name evidence="6" type="ORF">ERS852471_03043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268031.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12542">
        <property type="protein sequence ID" value="CUP12542"/>
        <property type="gene ID" value="ERS852471_03043"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="34824" checksum="4798CA0CC1C448B2" modified="2016-09-07" version="1">MEEKKPLLKVENLKQYFKVNKKFMVRAVNGVSFNIYQGETYGLVGESGSGKSTIGRSIIRLYNPTGGKITFDGVDVTGKLSKKEEKHLRTNMQMIFQDPMACLNPRKKVLDIIAQGLDIHGLCKDKKEREEKVYKILEKVGLSREHASRYPHQFSGGQRQRIGIARALIMNPKLIIADEAISALDVSIQAQVVNLMKDIQEETNIAFLFIAHDLSMVKYISDRIGVLHLGNLLETGTTEEIFSNPIHPYTKSLISAIPHPNPIVEKVRIAEEYCYETSGIDYSKGKEQHVGGTHYVLATDEEFKSWVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KNR2</accession>
    <name>A0A174KNR2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268000.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11488">
        <property type="protein sequence ID" value="CUP11488"/>
        <property type="gene ID" value="ERS852471_03029"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16867" checksum="97A9B65498F00ABC" modified="2016-09-07" version="1">MYGLVPFKFNNRGNRGLTINDMFQDFFNDDILSPFTEANHFKADIRETPDEYLIQAELPGVEKNDINIEYNNNCLTIHAVRKEEHEETKDNFIRKERHYGEVSRSFCVNNIDKAQIQAKFDNGVLSIRLPKQEKTVNNTKIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KPF5</accession>
    <name>A0A174KPF5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_03073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268087.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13883">
        <property type="protein sequence ID" value="CUP13883"/>
        <property type="gene ID" value="ERS852471_03073"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="19115" checksum="F3CF9D98CFC2D974" modified="2016-09-07" version="1">MKVNGTLINYYFHCRRQCYLHGNRLNLEDNSEIVKIGKAMHEEKATSENSEISIDNIKIDKLTKEYLTEVKKSDADVEAAKWQLLYYLKVLKDKGIVRRGKLECIEKNKSDNKILYFELTNEIERELLNYIEDIDKLLTGGKVPKVLNSAKCKKCAYYEYCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KVJ5</accession>
    <name>A0A174KVJ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">arlR_3</name>
        <name evidence="9" type="ORF">ERS852471_03059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268059.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13219">
        <property type="protein sequence ID" value="CUP13219"/>
        <property type="gene ID" value="ERS852471_03059"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="225" mass="25645" checksum="78B9571A8FD06941" modified="2016-09-07" version="1">MVKVLIVEDEEKIARFIELELMHEGYKVIKANNGRTGLEIAESGEADLVILDVMLPEINGLEVLRRLRRTSDVPVIMLTARDAVMDKVSGLDAGADDYVTKPFAIEELLARIRTALKKRVVTVKKEDILRCGLLTLDKMKHKVTYDNTEVELTNREFTLLQILMENKNIVLTRDVLIEKICGYDYVGETNVIDVYVRFLRTKIDDAFKTKIITTVRGVGYVIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KYR1</accession>
    <name>A0A174KYR1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spsA_3</name>
        <name evidence="2" type="ORF">ERS852471_03140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268202.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17444">
        <property type="protein sequence ID" value="CUP17444"/>
        <property type="gene ID" value="ERS852471_03140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="359" mass="42806" checksum="D9CB936777E00EDA" modified="2016-09-07" version="1">MSTKNVNYTNEKLFEECMNKNILDSKSYENLIKQEKYNKIKLMQTEITETQNKISIIIPTYNRRLQLLECINSILKQTYKNFEIIVVDDCSTDETEEYISKLLSDNRIKYLKNLKNSGPGYSRKVGFEKSSGEFIIFCDDDDYYIDSNYFTDAINIFKDGEISLICSNTFTHFEKENTFKFLDINFDNTICVEEYLENFQYKYMKPNSTFSAIFRKNKLVNGDLKNMKMVNDSSIYMRGLISGGKVFVNRKIIGVYRVHSQNITLTIKADFIIENLKEKKYIYERIVENKLFNGADKWLSKQIEVTFKYLLWCSNPTRKEINKIFNWILKNTNKNINLIIKLWLYRQFVRLRNMKERFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LAZ7</accession>
    <name>A0A174LAZ7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="4 7">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pduL</name>
        <name evidence="8" type="ORF">ERS852471_03180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PduL family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268269.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19687">
        <property type="protein sequence ID" value="CUP19687"/>
        <property type="gene ID" value="ERS852471_03180"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1156172at2"/>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP19687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="23295" checksum="A750717F7F6444BA" modified="2016-09-07" version="1">MNETLVQLITEKVMDVLKNEQPSSKKEVKVGVSARHIHLSKEHLEVLFGKGYELNVKKYLMGDQFASEELVTIVGPKLRSIEKVRILGPVRKETQVEISATDAITLGVKAPVRLSGDTKSSASITIVGPKGTVRIDEGCIIAKRHIHMHPEDSKRLGIGEGVVSVRIKGDRAGILENVDVRVREDFHFEMHIDTDEANALGIKNGSFVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LI17</accession>
    <name>A0A174LI17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaJ_2</name>
        <name evidence="3" type="ORF">ERS852471_03209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268324.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21290">
        <property type="protein sequence ID" value="CUP21290"/>
        <property type="gene ID" value="ERS852471_03209"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1520143at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP21290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="23002" checksum="33CEE4912C7CAF1C" modified="2016-09-07" version="1">MNPYEVLGVKQGASQEEIKAAYRKLVKQYHPDQYGDNPLKDLAQEKLTEVNKAYDMLKNGGGSTGSSYNSNYNNNSNSSYSGGYSNNVADYAEIRRLIQMRNNIEAERRLNAMANRDAEWHFLYGAVQLNKGWFDSALSNIEKACQMDPNNFEYRQSLNQLKMRGGGYANPYRTSQGGVDACTCCNNLICADCLCEMMGGDLIGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LN91</accession>
    <name>A0A174LN91_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence damage-inducible protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cinA</name>
        <name evidence="2" type="ORF">ERS852471_03284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268450.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25573">
        <property type="protein sequence ID" value="CUP25573"/>
        <property type="gene ID" value="ERS852471_03284"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="17922" checksum="74E9CBBD3A1C4FE5" modified="2016-09-07" version="1">MKNIDINKDLEYIIGEILIKNHLTISTAESCTGGMVAAKLISYPGISAAYLEGSVTYSNEAKISRLGVREETLLQYGAVSEETAREMVNGIAKVSGSKVAISTTGLAGPGGGSIEKPVGLVYIGIYLNGETVVKKFNFTGERNEIRKETTISALKMLIDLLTKRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LSG9</accession>
    <name>A0A174LSG9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268448.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25537">
        <property type="protein sequence ID" value="CUP25537"/>
        <property type="gene ID" value="ERS852471_03283"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026165at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP25537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="8902" checksum="379D1B9BF2970DEF" modified="2016-09-07" version="1">MSDYKMDIRGALGLGEYSDIHDYMGIVDKNDNFTITLDTKNKQHISIITSMLKENDFNILEQGISSGGDYYITANKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M4Y7</accession>
    <name>A0A174M4Y7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cassette chromosome recombinase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000049">
        <property type="protein sequence ID" value="CUP29070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29070">
        <property type="protein sequence ID" value="CUP29070"/>
        <property type="gene ID" value="ERS852471_03334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP29070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="238" mass="27523" checksum="F408E92D86A9D90C" modified="2016-09-07" version="1">MVISRTTNKLADGTKKRIAYYCCGAWKNKGTSVCNSNTIRVDKANEYVFNRISELLSNEKMVKSIVNNINKERHKKISPAKKELERIDKELEKIDRKKTKLFEAYEEEIISKEEFKERKDELNKRAKSLQEEKEPLLVTLSDDVSEEIPYEFIKSILENFSKVLTESATREQQKKLLHMIISEITINEAREIDSIKLKINDNLVDYISKEEGVSIKGTPSSFMLRNIGMSVLNLDIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLG6</accession>
    <name>A0A173XLG6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphotransferase system domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ERS852471_00044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262730.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51248">
        <property type="protein sequence ID" value="CUN51248"/>
        <property type="gene ID" value="ERS852471_00044"/>
    </dbReference>
    <dbReference type="OrthoDB" id="328780at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="114"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN51248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="474" mass="50223" checksum="D376E3503435B822" modified="2016-09-07" version="1">MTNQDLAKKIIELVGGKNNIVKAANCMTRLRMTVKNECLVQKDELKNTEGVLGIVDNGNYIQIVLGPGKAKKVTDICVEELGIPRDGVVTEDWKQNKDAIKGGQKKGKFKQAINTIANIFILLIPAIIAAGIFNGLASLITTLQGQGILSAEGFWKMTQLMFSLIGGGFLSYFAIYTGINSAKQFGATEGLGGMLGAMSISANIVTISTTLGLYDESVPLNSILTTGKGGIIGVIIGVYILAKIEKAMRKRIPDVLDLILTPLLTLLISGILFVFIIMPVAGFLSDGLVSVLSIFINSSNPVVSVISGYILSALFLPMVLFGLHHGLIPIYAVQLEAMGGVSLFPVLAMAGAGQVGAAIAIYFIAKKVKNNRLQKVIAGALPAGFLGVGEPLIYGVTLPMFKPFITAGLGAGFGGAYVMLTHVLANSWGPSGLVAIPIMKPECMLNYFIGLIISYVAGFIITYFVIKESDVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4C1</accession>
    <name>A0A173Y4C1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein Hfq</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">hfq</name>
        <name evidence="2" type="ORF">ERS852471_00194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hfq family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263008.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58764">
        <property type="protein sequence ID" value="CUN58764"/>
        <property type="gene ID" value="ERS852471_00194"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1989988at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01716">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00436">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34772">
        <property type="entry name" value="PTHR34772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02383">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="8861" checksum="28FAA49E3816B966" modified="2016-09-07" version="1">MNKQTNNLQDIFLNNARKNRIPVSIYLTNGFLIKGYVKGFDNFTVILDSDGKQMLVYKHAVTTITPATPILFNNIDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4K2</accession>
    <name>A0A173Y4K2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57588">
        <property type="protein sequence ID" value="CUN57588"/>
        <property type="gene ID" value="ERS852471_00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="15275" checksum="749DD237F35885F7" modified="2016-09-07" version="1">MNYALIQNLININDYTTAELLLKSNPCNDSIWHYLYSKVLLSKQWFDEALNHLKIANDLSPNNSIYKDDLVNFFGRGKRYSDDYNRSGYRHHNRGCSCCCCDDCCCDCNFSCCDLICLDTCCECMGGDLIDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0F9</accession>
    <name>A0A173Z0F9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">ERS852471_00345</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263297.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68926">
        <property type="protein sequence ID" value="CUN68926"/>
        <property type="gene ID" value="ERS852471_00345"/>
    </dbReference>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="129"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="237" mass="27097" checksum="E182A0BEC49A970E" modified="2016-09-07" version="1">MKINILTLFPEMFDIFNHSIVGKAREKNLISIEATNIRDYTLNKHKKVDDYPYGGGAGMVMSAQPVVDSIRAVKKNNKGKVIFLGPRGKTFDQKMAEELSKEDELIFLCGHYEGIDQRAFKEVDMEISLGDFVLTGGEMAAIPVIDSILRLVPGVLNKEESHQDESFSDGLLEYPQYTRPEIFEDERVPDVLLSGHHENIRKWRRLQSLLVTKERRSDLFKKITLSKEDIKLLNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z397</accession>
    <name>A0A173Z397_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263342.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70327">
        <property type="protein sequence ID" value="CUN70327"/>
        <property type="gene ID" value="ERS852471_00369"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1979925at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="16706" checksum="59B3237074B338A8" modified="2016-09-07" version="1">MNFLKGSYGVDLLSLFLILLSCILNIWDITRIFSIALLIFAFYRAFSKKIYKRREEYNIFYTYTNKLLSKFGKSLPYNIPVYDLNNLSKIFENFNYWLNQKKNYKITKCPNCKQKLRLPRGKGNIVVTCKKCSTKFDFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z3G1</accession>
    <name>A0A173Z3G1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263340.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70280">
        <property type="protein sequence ID" value="CUN70280"/>
        <property type="gene ID" value="ERS852471_00368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN70280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="64" mass="7720" checksum="E2E0A812FF988482" modified="2016-09-07" version="1">MVEVLDVESIYKYKLYCNDDFVNEYIDRETIEKAKENLVELDKLREEAPEFKILDILEKFIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSF6</accession>
    <name>A0A173ZSF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ykoC</name>
        <name evidence="6" type="ORF">ERS852471_00488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263575.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78753">
        <property type="protein sequence ID" value="CUN78753"/>
        <property type="gene ID" value="ERS852471_00488"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="31280" checksum="59A24563F5DFAC5B" modified="2016-09-07" version="1">MSAMLEYQDLKSPIHKLTGATKLIALVFWALASMVTYDTRILGAMFIFSIIMFKVSKVKFKDISFVLYFILVFLLINNIAIFFFSPYEGVEIYKTRTDLFHLFGPYTVTTQQLFYQFNVTLKYFSIIPMALLFMVTTNPSEFAASLNRIGVSYKISYSVAIALRYIPDIQRDYHDISFAQQARGIDMSKKAGLTSRVKNSAAIIMPLIFSSLERIESISSAMELRAFGNNKKRTWYSGRPFEKRDYIAIAIVVCVFIAALVATKLNGGRFFNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZXW5</accession>
    <name>A0A173ZXW5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263628.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81064">
        <property type="protein sequence ID" value="CUN81064"/>
        <property type="gene ID" value="ERS852471_00519"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1240965at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="715" mass="77167" checksum="02BE3E956FC982D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZZ7</accession>
    <name>A0A173ZZZ7_9CLOT</name>
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        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhaM</name>
        <name evidence="2" type="ORF">ERS852471_00517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852471_00517"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="146"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="34629" checksum="9E2E300F8E350542" modified="2016-09-07" version="1">MSNKDIFLNDVKSGENIKISLMVMRIMFKDTSKVVAILADKSGDIKATIPSKKGDIVEGRVISVEGKKDSNFDVKKYEFIDEYEIEDYLPTVKRPVEDIMEELELYTDEYILSREGKSLNNYFFKNEEFLEKFKKAIGGVSMHHNYIGGLAEHTLGVMYLSIVFSERYNCKNKEIAILAAKLHDIGKIYEMSYDGPFKYTLQGEMEGHIVIGIQMLDKAFESEPNLYSDEFKARIKGCIVQHHGKPEFGSPKDMNMEESYIVHYADYVDATMNKIEKIKEKYPDGGWTDYDRKLEARLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4G6</accession>
    <name>A0A174A4G6_9CLOT</name>
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        <submittedName>
            <fullName evidence="3">Periplasmic molybdate-binding protein/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83404">
        <property type="protein sequence ID" value="CUN83404"/>
        <property type="gene ID" value="ERS852471_00550"/>
    </dbReference>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_17"/>
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        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="103"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="35498" checksum="19619538E86AD583" modified="2016-09-07" version="1">MNSNESLNAIEVAELLNITKNTVYELVKRGELPGYKVGKKLRIDKCDVNEYIENQKSGNNKKSLTKTKEVVVPKIDKNTISSNDIIIAGQDQILDILSEYIKANIKDVRVLRNNVGSYTNLYDLYNDKISVCSSHLWDGDSNGYNYEYVRRLLPGIPCILINLAYRMQGFYVAKGNPNNIKAWNDLANKNISIVNREKGSGTRVLLDEKLRANNIDSNSIRGYDIVRNSHLSVASSIARGEGDVGMGIEKVALQVKGIDFIPMQEERYDLVIKKSDLSSPIYKAIIDIIQSKDFRDEIDGLSGYDLRDIGKIIAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9I1</accession>
    <name>A0A174A9I1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase</fullName>
            <ecNumber evidence="16">1.4.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gltB</name>
        <name evidence="16" type="ORF">ERS852471_00565</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="16"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84460">
        <property type="protein sequence ID" value="CUN84460"/>
        <property type="gene ID" value="ERS852471_00565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="17"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1510" mass="168805" checksum="B6071FA75882C08C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9R0</accession>
    <name>A0A174A9R0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
            <ecNumber evidence="2">2.3.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">speG</name>
        <name evidence="2" type="ORF">ERS852471_00562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.57" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84286">
        <property type="protein sequence ID" value="CUN84286"/>
        <property type="gene ID" value="ERS852471_00562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN84286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="175" mass="20747" checksum="5F84139BF2546779" modified="2016-09-07" version="1">MDINLRKLSLEDKKEYWNSGFKNQDEEVMYYTGTTNNPTEEQICNYIDRVVKDDSREDYVICDLNNNILGEAVLMEIDDDNKSCHFRIAIFNKESFGKGIGYKATVEILRIAFEKLKLHRVELEVFDYNLRAKKMYEKVGFKVEGLKRDGIFIDNQYRGIYIMSILEDEYRKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQD4</accession>
    <name>A0A174AQD4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FliB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fliU_2</name>
        <name evidence="1" type="ORF">ERS852471_00646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263858.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89810">
        <property type="protein sequence ID" value="CUN89810"/>
        <property type="gene ID" value="ERS852471_00646"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1674644at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="403" mass="48334" checksum="4A275624F0505890" modified="2016-09-07" version="1">MGKKVKSIYPEYYNEFKCIGGSCEDSCCIGWDIDIDKVTFRKYYKVQDLEMKRMFQKNVHNNEESFSDDVDYGKVKLKDDKRCPFLDCNNYCVIHSKLGEDYLSNVCTCFPRITNLVDGCYERSLDVACPEAARILLLNEEGIKFKESEEEIGKHILSNQVDTKSKELSNSLAKYFKEIRKVCIKIIQNRKLELTERLFVLGEFINNLEDESESNFNNIEKFINNYDINRTQGFYEKNSLYFMLQIDFFKKMVSLLNIDKEVDSDLFKEYTKQIIDSFNLNREDADNRTYIEVFEEYNKEFLDKYTYIFENYLVNFIYNNMFPFNEKESIFDGYIMLLMRYSFIRFYLVGKYIKERNDSKEEIVRFIQVFSKTIEHHRSYLTKSIRYIKEKEFDNIEFAKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B159</accession>
    <name>A0A174B159_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_1</name>
        <name evidence="2" type="ORF">ERS852471_00697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94821">
        <property type="protein sequence ID" value="CUN94821"/>
        <property type="gene ID" value="ERS852471_00697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="134" mass="15098" checksum="E5CB791FDE0B6841" modified="2016-09-07" version="1">MFLILKLDMTSSIPIYVQLRNQIVMGIGRGELEIGQGLPTVRQMADDIGVNMMTVNKAYNILKAEGYIEIDRRHGAKVNPALDTSKEFKEKVEQELELIIAESAIKGIDYKEFMKMCEDIFNNMNGLKIVGNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3A4</accession>
    <name>A0A174B3A4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263981.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95372">
        <property type="protein sequence ID" value="CUN95372"/>
        <property type="gene ID" value="ERS852471_00704"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015389at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="186" mass="22485" checksum="DEA8E976B421C7FE" modified="2016-09-07" version="1">MLINTHLIIGEFCFNLCNEKYDLMLNKRKFLYGCIEPDLHKRKNKIKHTYTVSKEKMKEYNDLIENGNMNTDEISFTLGRIAHYIADCFCKYHLEEYYGKDMAKHFMYEVTLHKKLKNILRYKQEIFDNVLDNMKEDRDYLEELNINRESYLSLDEDCINDIYFTIKTTCYLLYMTQVYFGNLVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3Y0</accession>
    <name>A0A174B3Y0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3887 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263974.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95113">
        <property type="protein sequence ID" value="CUN95113"/>
        <property type="gene ID" value="ERS852471_00700"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902150at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018124" description="DUF3887 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3887" evidence="2">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN95113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14684" checksum="4F4B55CC68332E82" modified="2016-09-07" version="1">MKKFIKVLSIILCLFMFVSCSAGKLSDAYNEDEVKAAAEEVINELNDKNYDGILEDSSDELKISLPDNKLQETWEGFSKDIGEFNSILNMTLAEKNGYAVAITNVKYDNKKVTFTLSFNKEMKLAGIYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B940</accession>
    <name>A0A174B940_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="3">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cfa</name>
        <name evidence="3" type="ORF">ERS852471_00715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263996.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96135">
        <property type="protein sequence ID" value="CUN96135"/>
        <property type="gene ID" value="ERS852471_00715"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN96135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="393" mass="45744" checksum="685E6635CECB4837" modified="2016-09-07" version="1">MNVEKTFLKTFLKNFEGEAFAVDFWDGEEVVLGNGEPLFRVHIKKPLNKKDLLSSTSLAFGEAYMNGDVEFEGDLFLALNTVLKYMNKFNSDNKALPEIFHKITNKSKQKEEVSSHYDIGNDFYSLWLDETMSYSCGYFKNENDTLYQAQMNKIHHILKKLNLKEGQSLLDIGCGWGMLLIEAAKKYKIKGLGITLSQEQFNKFSERIKEENLEDYLEVKLMDYRDLKKSKLSFDRVVSVGMIEHVGRPNYDLFFENVNAVLKEGGVFLLHYISGIKESEGDAWIKKYIFPGGVIPSLREIINISGDYNYHVIDVESLRLHYTKTLLEWYKNFNNNIDKVREMFDEKFIRMWSMYLCSCAATFNNGIIDLHQILFTKGIDNDLPLTRDYLYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBU3</accession>
    <name>A0A174BBU3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR family transcriptional regulator</fullName>
            <ecNumber evidence="4">2.6.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lysN_1</name>
        <name evidence="4" type="ORF">ERS852471_00735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264030.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97195">
        <property type="protein sequence ID" value="CUN97195"/>
        <property type="gene ID" value="ERS852471_00735"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN97195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="485" mass="55716" checksum="72582372EA9B96E1" modified="2016-09-07" version="1">MIFSSLEFNNNEPIYLQIENYIKYMIKNNMVVTDAKLPSSRDLSKILGVSRNSVIVAYENLEADGIVYTIKGRGTFVSKNKEDYKNGWKVSWDNMINNYGRLAEELDIVKTEIPWERGMISFKSISPDGSLFDIDEFKKSFLNRISLEGDKILNYGYAKGYKPLIDYLLEYMKQKGVSIENKDIIITNGFTEGLEMILNTFCNPGDKILCENPTHNTSIKIMKILGLDIIGVKMNQDGIDIEELENKLKNNKIKFGYLIPSYHNPTGIVMKAEKRQQVYKLFRKYDIPIIEDGFNEELLYNSTHISPLSSIDKGGNGVIYISSFSKILFPGLRVGWILADKRIIDVLESVKRCKNIHTSFLDQGILYEYLKSGAFDKNVKKIRKVYREKYDFALNCINKYIKPDFIWGEGALHIYIGIEGVKSRKLLEECYKENVIFTPGDIFSVDNSCENTLRIGLTRLSLNQIEEGIKIIGKNVERIKLNEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGW6</accession>
    <name>A0A174BGW6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264111.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99419">
        <property type="protein sequence ID" value="CUN99419"/>
        <property type="gene ID" value="ERS852471_00777"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1810920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="15732" checksum="2762EDABF760EC93" modified="2016-09-07" version="1">MGFKDKLGKYYSDAYMQKYGDRMTSVSGTILSVKTETKSILGIFNKIRVYLVVKPEAGKQVVKCQYKMNKWFKKPTFIDVNQGHKVIIMGIKGEKGKAEADTVLISNIANLTTKKDLHPFDHAQIKKARQQATKMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BLJ8</accession>
    <name>A0A174BLJ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeZ</name>
        <name evidence="2" type="ORF">ERS852471_00819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264199.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01624">
        <property type="protein sequence ID" value="CUO01624"/>
        <property type="gene ID" value="ERS852471_00819"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="11661" checksum="5BDB1FCF7645D54D" modified="2016-09-07" version="1">MFGFFNRNTGKSINVNDIDSLVGKVELIDIREPYEYNSGSIVSAKNIPMKTLLGNPSKYLSKDKEYYIMCQSGGRSSMACSELAKMGYDVINVSGGIGSYLGKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BM26</accession>
    <name>A0A174BM26_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrichrome ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">feuC_1</name>
        <name evidence="8" type="ORF">ERS852471_00802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264166.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00735">
        <property type="protein sequence ID" value="CUO00735"/>
        <property type="gene ID" value="ERS852471_00802"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO00735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="34747" checksum="95AC00F3446AF203" modified="2016-09-07" version="1">MKTLDKKFRGLFIAVALIILVAGILISLKLGSINITFGELIKGLFTGQTDGNIGIIKDLRMPRVIIAVLVGANLAISGVLLQSVIRNPLADPYITGISTGACLVTVFLMVFMPGVTNSRPIFGFLGGLVSCGLVYFMAYKKGLSPIRIVLAGAACNALLGGFSSMITVSAGLGSSNIQKWMMGSLATVNWSNVYVLAIYSVIGIAAAFMLSKICNVLALGSKNAKSLGFNADVYMIVVTAVAVFLAGISTAIAGVISFVGLVVPHICRMIIGSDHKYLIPCSGIIGALLVLFADTVGRMAMRPNEIPVGVVTCIFGAPFFLYLLRRSDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C420</accession>
    <name>A0A174C420_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264395.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08162">
        <property type="protein sequence ID" value="CUO08162"/>
        <property type="gene ID" value="ERS852471_00916"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO08162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="38239" checksum="D5B19FB67F042EF3" modified="2016-09-07" version="1">MVKIIGSELKNIPWQDKPEGYEGVVWRHSANPIIGWNPTKKTARIFNSAVVPYEDGFIVIFRADHKHGKPQLHLGRSKDGLKWDIEDEEIHWKDEAGNDYQPNYSYDPRLVKIEDTYYIVWCAEFGGAALGLGMTKDFKEFTRLENPFIPFNRNGVLFPRKINDKYMLLSRPSDSGHTPFGDIFLSESPDLVHWGKHRRVMSKGGSGWWQGTKIGGGAIPIETTEGWLLFYHGVSGTCNGFVYSMGAAILDKDNPSKVLYRTRDYLLTPEKDYETTGFVPNVAFPCATLHDAETGRIAIYYGAADTYVAVAYAQVDELVKYIKENSELVYGDDIEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9C5</accession>
    <name>A0A174C9C5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_2</name>
        <name evidence="5" type="ORF">ERS852471_00953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264467.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10092">
        <property type="protein sequence ID" value="CUO10092"/>
        <property type="gene ID" value="ERS852471_00953"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO10092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="26487" checksum="7341B676E6BF50DE" modified="2016-09-07" version="1">MNKTILKVEGLSKSFKKRRIVDNVSFEAKAGEILGFLGANGAGKTTTIRMITGLISADSGTVIIDGHNIKSNFEKAMDNVGAIVEIPFLYEYMTGMENIKLFAKLYKASEEGVNEAIKVSGLKDRLNDKVKEYSLGMKQRIGLAVALMKQPKLLILDEPTNGLDPMGIKDLREFLKDLSHNKNISVVVSSHILMEMEQLCDRVVIISDGKVICTKTMDEINKESSLEEVFINSIKEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDU5</accession>
    <name>A0A174CDU5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin oxidoreductase, 4Fe-4S cluster-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264522.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11711">
        <property type="protein sequence ID" value="CUO11711"/>
        <property type="gene ID" value="ERS852471_00987"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1751763at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="12253" checksum="B7B5B08879986951" modified="2016-09-07" version="1">MKKELICISCPLGCHLTVDADNKTVTGNTCKRGEVYGLNEVINPVRVITSTVKIEGARLPVLPVKTNGAIPKSLNFEAIKVINDVICKAPIKVGDIIIKDILGTGVDVVASRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHM7</accession>
    <name>A0A174CHM7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ERS852471_01005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264537.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12733">
        <property type="protein sequence ID" value="CUO12733"/>
        <property type="gene ID" value="ERS852471_01005"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="11">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="162" mass="17180" checksum="B6AB75CEF4F4F5E2" modified="2016-09-07" version="1">MYCENCGMVVSDNSNFCSNCGAKVKKPILKCSNCGAEVKEYDTVCEKCGQIIERKTSNHTKSSTDVGVSSVNSNANSNSTAQNTNVNKKQKSKVVAGILGVLVGPFGVHRFYLGYIGIGVLQLILTFLSFGLASLWGFIEGILILCGVGITEDADGVPLSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CL81</accession>
    <name>A0A174CL81_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="4">SDH</shortName>
            <ecNumber evidence="1 4">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">aroE</name>
        <name evidence="6" type="ORF">ERS852471_01010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264542.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12969">
        <property type="protein sequence ID" value="CUO12969"/>
        <property type="gene ID" value="ERS852471_01010"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="271" mass="31138" checksum="DA961B5DE8B85F6C" modified="2016-09-07" version="1">MDFFGILGEKLSHSLSPEIHGTILKSIDKCGEYKLFEIERDKLGEFIEAVKLFNVRGFNITIPYKQEIMKYLDFISEEAKRIGAVNSVVLKDNKLYGYNTDYFGFGATFERKKITFKDKIAVILGTGGACKAALTYILDNEIKELYLVSRNPKDVSLNVDDKRLKVISYDELKCIKGNIIINSTPVGMYPNKDRCPIGKDIIDNYDVVMDLIYNPLETKFLEYGREKEKITLDGLYMLVAQAVKAQEIFQEINIDDEIIDNIYRDLQDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZ38</accession>
    <name>A0A174CZ38_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system, ATPase and permease components</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yheH_1</name>
        <name evidence="11" type="ORF">ERS852471_01065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17055">
        <property type="protein sequence ID" value="CUO17055"/>
        <property type="gene ID" value="ERS852471_01065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="49"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="415"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="448"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO17055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="673" mass="74053" checksum="FE5E158FDC99EE35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7I3</accession>
    <name>A0A174D7I3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264647.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20249">
        <property type="protein sequence ID" value="CUO20249"/>
        <property type="gene ID" value="ERS852471_01128"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="251"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO20249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="665" mass="75595" checksum="9CB52694CFD2A601" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7T1</accession>
    <name>A0A174D7T1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21287">
        <property type="protein sequence ID" value="CUO21287"/>
        <property type="gene ID" value="ERS852471_01149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="55" mass="6521" checksum="A8D142A67FECCAD6" modified="2016-09-07" version="1">MILIKVDKLKEERLIIVRNKIAEIISLISIESNSEKKSMYEKQYEELLKELKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D820</accession>
    <name>A0A174D820_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="6 8">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tenA</name>
        <name evidence="10" type="ORF">ERS852471_01158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TenA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="6 8"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264673.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21694">
        <property type="protein sequence ID" value="CUO21694"/>
        <property type="gene ID" value="ERS852471_01158"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1537025at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="9">
        <location>
            <begin position="10"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO21694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="25996" checksum="61353BF360E51D5A" modified="2016-09-07" version="1">MKFTDELFEEVKELWDRYLEHPFVKGIGEGTLDKEKFKKYLIQDYLYLKDYAKVFALGLVKAKTMKEMKFYSDSIRGTLEDETQVHTNYLRYFGLSDEAVEKYRCELTTASYTSYMLAIASKGGSKEIAMTIMPCTWSYYYIGKNLYDRYKDTLEDNFYKPWIEEYSSEEFKGCADAWINYIDYLCENISESEKEDLKDIFIKSSLYEMEFWNMAYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DCT0</accession>
    <name>A0A174DCT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine-precursor transport protein ThiW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiW</name>
        <name evidence="2" type="ORF">ERS852471_01161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21848">
        <property type="protein sequence ID" value="CUO21848"/>
        <property type="gene ID" value="ERS852471_01161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012652">
        <property type="entry name" value="ThiW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09512">
        <property type="entry name" value="ThiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02359">
        <property type="entry name" value="thiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="187" mass="19761" checksum="88CF8E9080A9C6F2" modified="2016-09-07" version="1">MQLVLRVKLGMKDIRHKIGEVCMEITKSSLSTTKKIVLSGILVSLATVLGTFSIPILGAKASPVQHFINVVTGITLGPAYGMGCAFISSLLRNILGTGSVLAFPGSMIGAFLAGTLYKKYHKSELAVIGEVIGTGVIGALVAYPLAAFVLGKEVAMFVYIVPFTTSSLLGSIIAYIVLKLKVIRNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DDL7</accession>
    <name>A0A174DDL7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_01167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22135">
        <property type="protein sequence ID" value="CUO22135"/>
        <property type="gene ID" value="ERS852471_01167"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="10"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO22135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="423" mass="46660" checksum="1A58CA6A06B320CF" modified="2016-09-07" version="1">MRSEKSYKWTIIACYIGYFVQATVINLVPILFVTLREGYGLSYSQLGALVLINFVTQVIFDVVFSRPVDKYGFRPFVVVAHGICALGLILFSITPRVFSENIFAGFVLSTIIFSGGGGLLELVISPIIDSIPSDDKATAMSLLHSFYAWGQVTVVVITSIFLFSFGKEKWWIIMMIWAIVPIVNFFIFMRVPLTQKLHESKIMKIRELIKNPIFIVAFFAIMLGAASEVSMNQWAATYMERGLLIPKFVGDMLGMCFFAIMLGIGRAIYGVYGSRININKVMIWGSLGAAICYLVVAISPYNWLSIIACGICGIFVSLLWPGTLVVASSRLPLAGASMFALLAAAGDVGAAIGPWLIGRVTDFTTSNWTSSASYSINSEQFGLRVAILLAAVFPILTMIFHSILKNIKVKQKSYECEKISYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEP4</accession>
    <name>A0A174DEP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FtsX-like permease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264690.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22520">
        <property type="protein sequence ID" value="CUO22520"/>
        <property type="gene ID" value="ERS852471_01176"/>
    </dbReference>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="43352" checksum="4B149802A4D45C0A" modified="2016-09-07" version="1">MFRYSIKSLLSKKTVSILFIISICIAISISMLSINISSQIDEGFYQVDKKYDIIVGPKGSSTQLVMSSLFFSDDPLGTIDTDYLDNIMDEYEVTTIVPLAMADSYKGNRIVGTTTDLLNDYSLKSGELFKEDYEVVVGYNIATSYNLSIGDEITTSHGTSNYAEEHTSSPYILVGILDKTNTSYDNTLFTSINSVWNAHDEEHIHSEEEEHSHEGDDHNMGYTSILVKTGSLATANKIETSLSEDVDVQAVNTTKILRKLVGNIDMSKQVALLLCGIIVVLASLLTCVMSFLMLVNSKNDIKLLKFLGMNKSKIYSYVLGQVIILIAVSITISLLINRVALSLVNNISSSLGIVLDLTKVYPTEFYIVFIYVGVIIVSTLIYSYIRVKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLS1</accession>
    <name>A0A174DLS1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SprT-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264744.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26157">
        <property type="protein sequence ID" value="CUO26157"/>
        <property type="gene ID" value="ERS852471_01225"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1996538at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="175" mass="20698" checksum="1280556DFE0BF3BC" modified="2016-09-07" version="1">MYKKWTIKEIKEELIDIGIKLEYPTNLKVEISNRATKRMGAFFYIKEKESIVPIKFVFAKRLIDGNYPEEVVREVIIHEYLHYYCDTKTGLSNGHNKFFKSMCLKCGISSKATFSYKSINEDIYIKKHVKIYNIYCRKCGRLVCVHRRRDAAERKIKGYISKCCNSRLECKINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DP73</accession>
    <name>A0A174DP73_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264741.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26028">
        <property type="protein sequence ID" value="CUO26028"/>
        <property type="gene ID" value="ERS852471_01222"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922927at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="107" mass="12317" checksum="EC425041442CA504" modified="2016-09-07" version="1">MSYALKFVEVDLSNESIKEKSEVQVQDIIIKDVEDIIIHGKVYDNNNNPVDQAVVKVFYTNDDGNEIGYCHVFTDNDGEYMVNLPYEIFKDKKIKIKAVKANKLIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQU7</accession>
    <name>A0A174DQU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MobA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264795.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27597">
        <property type="protein sequence ID" value="CUO27597"/>
        <property type="gene ID" value="ERS852471_01255"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1432587at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="22834" checksum="D1777E1A1E44495E" modified="2016-09-07" version="1">MKVNGLILAAGMSSRMGDFKPLMKINNKTMIERSIDSMLMGGSYSVTLVLGYQGERIERLLKRKGYLEKNVILVYNKNYEVTNMIDSVKIGINNIGECDAFYLLPGDMPAIKANTFIKVRETMDRTRAKAVFPTIDGYKKHPPLISIELVKDILEFNSDGGLREMWKELDSEIITVPVDDLGCNLDVDTKSQYINVCKYMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXW0</accession>
    <name>A0A174DXW0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29026">
        <property type="protein sequence ID" value="CUO29026"/>
        <property type="gene ID" value="ERS852471_01286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="204" mass="23624" checksum="0E3D71682BC60A56" modified="2016-09-07" version="1">MNNNFQNDKFKKDKLKKIYFGVGVIVLLGMCFSLSYLITDWITKPKYENALEEKTVYNSTEVLEDNTTIALMIGDSIDKEQSLKDFKEENNIQVDVNQQFLIDFLDDSGYKLEALSDDRIVFSKENSDNTLIGGKYYLGEKDGYFAIYKTDENGKAFIESESDVFRDYKKVNTIPIAAEEEIKSFKHYYDSKEEALERLAGYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E692</accession>
    <name>A0A174E692_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glyS</name>
        <name evidence="8" type="synonym">glyQS</name>
        <name evidence="10" type="ORF">ERS852471_01362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264997.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33442">
        <property type="protein sequence ID" value="CUO33442"/>
        <property type="gene ID" value="ERS852471_01362"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626850at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="155"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="463" mass="53113" checksum="C871B220652C9E64" modified="2016-09-07" version="1">MAVEKTMEKIVALCKSRGFVFPGSEIYGGLANSWDYGPLGVEFKNNVKKAWWKKFVQESPYNVGVDCAILMNPEVWVASGHVGGFSDPLMDCKECKSRFRADKLVEDHMTESGVEVASADGWTNEELMEYITKNNIVCPKCGKMNYTDIRKFNLMFKTFQGITEDSASTVYLRPETAQGIFVNFKSVQRTSRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWFGYWKDYCWNFLLNLGVKAECLRMRDHGEEELSFYSNATSDIEYLFPFGWGELWGIADRTDYDLKKHAEHSGTDMTYLDPTTNEKYVPYCIEPSLGADRVALAFLVDAYDEEELEGGDVRTVMHLHPALAPYKAAVLPLSKKLSEKADEVYDMLSKNFNIEYDETGSIGKRYRRQDEIGTPFCITIDFETENDGCVTIRHRDSMTQERVKIEELNDFIAKSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7E9</accession>
    <name>A0A174E7E9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">fhs</name>
        <name evidence="7" type="ORF">ERS852471_01371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265007.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33714">
        <property type="protein sequence ID" value="CUO33714"/>
        <property type="gene ID" value="ERS852471_01371"/>
    </dbReference>
    <dbReference type="OrthoDB" id="177859at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="553" mass="59758" checksum="43B0EA9EEC8F0E57" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAC2</accession>
    <name>A0A174EAC2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">murD</name>
        <name evidence="11" type="ORF">ERS852471_01361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264995.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33409">
        <property type="protein sequence ID" value="CUO33409"/>
        <property type="gene ID" value="ERS852471_01361"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="51683" checksum="64A054A35D189C69" modified="2016-09-07" version="1">MKRDFKEFKEFIKNKKVAVVGIGVSNIPLINFLLKLGSEVTAFDKKTKEDLGGVYDDFISKGVKMELGEHYLDNLTGFEVVFKTPSMRIDCDALVKVKNEGAYVTSEMEEFVRYCKGKVYAITGSDGKTTTTSIVAKLLEAEGYKTWVGGNIGTPLFANIEEIEDEHRVVLELSSFQLMTMNLPVDVAIVTNLTPNHLDMHKGMQEYIDSKKNIFLYQNESDILVVNREDEITYEFEKEAKGHIREFSSKRVLEHGAYYKEGALYLEDKKVCEKENIIIKGMHNVENYLAAFAATKDDVKIETMKNVAETFGGVEHRCEFVREIDGVKYYNDSIASTPTRTVAGLRAFDKKVILIAGGYDKHIPFEPLAEDGYPYIKEVVILGATKYKIKEAFEKLKLEKGIDVPTVMVESLEEAVEVSRKIATEGDIVTLSPACASFDMFPNFAVRGNKFKEIVNATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIU7</accession>
    <name>A0A174EIU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">appA_3</name>
        <name evidence="3" type="ORF">ERS852471_01462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265161.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37673">
        <property type="protein sequence ID" value="CUO37673"/>
        <property type="gene ID" value="ERS852471_01462"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020783" evidence="1">
        <location>
            <begin position="26"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="105"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO37673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="671" mass="74578" checksum="788CE28F1D67A9BA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJ91</accession>
    <name>A0A174EJ91_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.191</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rlmI</name>
        <name evidence="5" type="ORF">ERS852471_01463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.191" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265163.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37711">
        <property type="protein sequence ID" value="CUO37711"/>
        <property type="gene ID" value="ERS852471_01463"/>
    </dbReference>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="45063" checksum="90CF3E5A6E8C7050" modified="2016-09-07" version="1">MNSKFYLHQGKNKKAEQGRPWIYIDEINEYDGDYENGDIVEVYNHKNYFIGKGYINDKSKITIRIMTRDINEEIDEEFFKRRFAAAWDYRKTVIDTSSCRFIFGEADFLPGLTVDKFGDYYVIQISTLGMDKYRDIIVKILVEEYGAKGVYERSDIKTREIEGLEQTKGFLTEPFDTNVEIIENGVKYIVDLENGQKTGFFLDQKENRAAMHRICKGRDVLDCFTHTGSFALNAGIAGAKSVLGIDVSQHAIDCARRNAELNNLQDTVKFECHNAFDVLGDWSREGRQFDVVILDPPAFTKSRNTVNAAIRGYKEINLRGLKMVKPGGYFATCSCSHYMSEEQLKKTVLEAAHDARRTLRQIEVRTQSSDHPILWNSDESYYLKFFIFQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJ94</accession>
    <name>A0A174EJ94_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M24</fullName>
            <ecNumber evidence="4">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pepP</name>
        <name evidence="4" type="ORF">ERS852471_01442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265125.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36808">
        <property type="protein sequence ID" value="CUO36808"/>
        <property type="gene ID" value="ERS852471_01442"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="420" mass="47706" checksum="BCEC98BABCF726C4" modified="2016-09-07" version="1">MKADFFKNNRKRLFEKIKDNSIVILFAGNAPKKTADEAYPFTPNRNFYYSTGISEENHILVMSKVGGSEKSTLFIKDIDPDLERWIGKSIRKDEATEISGIEDVKFKSQFDSEIHRLLCLKEEVNLYLDLERDSISSTSSIANEFAKDIISKYPQVMIKNIFSIFGELRLVKSEEEVDNIKKAISITIEGIEALMKNSKAGIKEYQLESYFDFVCKNNGVKDFAFKTIAAAGKNAATLHYVANDSELKDGDLIQFDLGAQYNFYNADISRAFPVNGKFTERQKAVYNAVLKVNEEIINDIKPGKTFRDINKKATDLIAEECIKLGLIKEKSEVSKYYFHSIGHSLGLDTHDLETPHRDITFKEGVVYTVEPGIYIEEENMGIRIEDDILVTKDGVVNLTSGMIKTVEEIETFMAKYNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMH6</accession>
    <name>A0A174EMH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE_1</name>
        <name evidence="4" type="ORF">ERS852471_01465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37796">
        <property type="protein sequence ID" value="CUO37796"/>
        <property type="gene ID" value="ERS852471_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO37796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="21067" checksum="1AE1C1E0E76D1791" modified="2016-09-07" version="1">MEASMETQNNKVVSIEVRRAKNGDKDAFCNLIRINKMSMYRVAKSILSKEEDVEDAVSEAILKAYKNIKSLKDESLFKTWLIRIVINESNTIYKKRSKEISVENEHFINVQVNDKYKDLTLYNAINSLDEDLRTTTILFYFEDMKYKDIANALGIKEGTVKSRLSRAKEKLYNILREDLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUL5</accession>
    <name>A0A174EUL5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">walR_1</name>
        <name evidence="11" type="ORF">ERS852471_01505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265244.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41017">
        <property type="protein sequence ID" value="CUO41017"/>
        <property type="gene ID" value="ERS852471_01505"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO41017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="237" mass="27105" checksum="314A659B14C8733E" modified="2016-09-07" version="1">MNKNRVLVVDDDKEIVEAIDIYLKNEGIEVIKAYDGMQAIEALIEKEVHLILMDIMMPKMDGLRTTMKIREEKNIPIILISAKSEDTDKILGLNMGADDYITKPFNPLEMIARVKSQLRRYTMLGNFGTVQQRGESNSIISSGGLSLNLDSKEVVVDGEIIKVTATEFGILELLLRNQGRVFSIDEIYEKVWKEPSYNAENTVAVHIRRIREKIEINPKDPKYLKVVWGIGYKIEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F373</accession>
    <name>A0A174F373_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Choline kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">licA</name>
        <name evidence="2" type="ORF">ERS852471_01555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265340.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43378">
        <property type="protein sequence ID" value="CUO43378"/>
        <property type="gene ID" value="ERS852471_01555"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="92"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="617" mass="71565" checksum="256146C618D86035" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3D8</accession>
    <name>A0A174F3D8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mnaA</name>
        <name evidence="3" type="ORF">ERS852471_01567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265366.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44087">
        <property type="protein sequence ID" value="CUO44087"/>
        <property type="gene ID" value="ERS852471_01567"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="42632" checksum="3494EA1CD8371B7E" modified="2016-09-07" version="1">MKKLRVMTIVGTRPEIIRLAEVIKKCDEYFEHILVHTGQNWDYTLNDVFFKELELREPDHFLGVVGENLGQTMGNIIAASYEILVKEKPEALLILGDTNSCLAAIAAKRLKIPVFHMEAGNRCFDQNVPEEINRRIVDVTSDVNLAYTEHARRYLLNEGMRKEYTFVTGSPLPEVFTKYMPKIDESDVLERLGLEKGKFILVSAHREENIDNDENFKSLIDALNSIAETYNMPVIYSTHPRSWKRIEAKGIKFHENIKQLKPFGFYDYNKLQKESFCVLSDSGSLAEESNIMGFPAVSIRTSTERPEAIDKGSVILGGITFDSITQAIEVITKQKEVGAELVKVHDYTDINVSMKVVNVIQGYTSVINKFIWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3E3</accession>
    <name>A0A174F3E3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265372.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44221">
        <property type="protein sequence ID" value="CUO44221"/>
        <property type="gene ID" value="ERS852471_01570"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="45113" checksum="2C89BB53B9B514DE" modified="2016-09-07" version="1">MKILVVSQYFWPEEFRINDICEGLIEQGHEVEVLTGIPNYPHGNFFEGHSIFKPGVKEYKGAKIRRVPLVPRGKDNFIKLGLNYISYTITASIASLGLLFNKYDRVFVFQLSPITLAIPGIIVSKIKKIPSIIYVQDLWPESLFSIKEVNNTKVRGILDKICSSIYKSFDKLLITSKSFEEELVNKGVSREKIDYFPQWAEDFYSLNESSKKNNKEEFVITFAGNIGKAQSVDTIIKAAKLAKKNKNIKWQILGDGSEFKYIKSLVNEFKLNETVSLLGRKPASDMPKYFSESDALIVTLKDDKVWRATLPAKVQSYMASGKPILAAISGEGNSVIKQSKCGLVGEAEDHIKLYENVIELYNMSEEEREILGNNGKKYFEDNFTRKILLNKLEQVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNK7</accession>
    <name>A0A174FNK7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">atpC</name>
        <name evidence="9" type="ORF">ERS852471_01710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51814">
        <property type="protein sequence ID" value="CUO51814"/>
        <property type="gene ID" value="ERS852471_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="7">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="15428" checksum="2BD9E32B4D91E723" modified="2016-09-07" version="1">MIYVEKQSKLTIVTNDNKKVEEAVVSVVTESDEGKIEILPNHTKSIISTIPTVTTFISSDGKEKNLFTSSGIIYIDNNSIKFCCDSINWPEEIDLDRAKLAEERAKKRLSEKGNTDTERAKNALLRAKARIEIKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPI0</accession>
    <name>A0A174FPI0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">ERS852471_01717</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265637.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52134">
        <property type="protein sequence ID" value="CUO52134"/>
        <property type="gene ID" value="ERS852471_01717"/>
    </dbReference>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO52134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="25324" checksum="87ABD2A6F84C856D" modified="2016-09-07" version="1">MESYKPIVSFNLGGLIIDIKPEAIIQLVIILLIGILAWYSTKDLKSKPQSKKQVIVEYLYNLIKNVVDSNMGKEYRDVIPFIGTLAIFILTMNLTGLVGIAAPTKNFSVTIALSLIVFVFIQVYTIRKTGIKRYFGGYAKPMAVMLPINILERVMLPISLALRLFGNILAATVLVELVYKALSSLAWIAEIGLPIPLHAYFDIFDGAIQMVIFVMLTMINTKITVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQ73</accession>
    <name>A0A174FQ73_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ribU</name>
        <name evidence="9" type="ORF">ERS852471_01685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265585.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50650">
        <property type="protein sequence ID" value="CUO50650"/>
        <property type="gene ID" value="ERS852471_01685"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1497256at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037778">
        <property type="entry name" value="UCP037778_transp_RibU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO50650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="21103" checksum="1515DF8BD2A87723" modified="2016-09-07" version="1">MNNSNKNVNKMIKISLLVAIAVVLMYFDFPIIPLFPWLKIDLSEVPALMGGFAYGPVAGGAIVILKVLLRFLVKGTQTGFIGELANIIVGLALVVPAAWIYNRNKSKKTAIIGMIVGGLVMEVLGIVANVYLLLPAYGMQMNPAELSKYITVGLLPFNGVKALIVSVITYLLYKKVSVAIFKVDSNFGKSKKQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRR8</accession>
    <name>A0A174FRR8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calycin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265667.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52934">
        <property type="protein sequence ID" value="CUO52934"/>
        <property type="gene ID" value="ERS852471_01734"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792951at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015231">
        <property type="entry name" value="DUF1934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09148">
        <property type="entry name" value="DUF1934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="15546" checksum="44B247B316569CDB" modified="2016-09-07" version="1">MEKNAIIQVKSFSDIDESDAIEVITPGKFIVKESSYEIIYEESEISGMKGTTTNLKIEEDRFVLERVGTTCTTMEFKIGEMGLSLYNTPYGMLHLHIDTKILDINIDENGGFIYAKYLLSAEGQPPITTEIKVKIKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYM9</accession>
    <name>A0A174FYM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding LysM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265679.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53205">
        <property type="protein sequence ID" value="CUO53205"/>
        <property type="gene ID" value="ERS852471_01740"/>
    </dbReference>
    <dbReference type="OrthoDB" id="231306at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024300">
        <property type="entry name" value="DUF3794"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12673">
        <property type="entry name" value="DUF3794"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="472"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="522" mass="59060" checksum="A379B42635D94779" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G3H4</accession>
    <name>A0A174G3H4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265734.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55379">
        <property type="protein sequence ID" value="CUO55379"/>
        <property type="gene ID" value="ERS852471_01766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO55379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="164" mass="19282" checksum="6761BAFF5FDAF315" modified="2016-09-07" version="1">MKRTFNVYSDNYFEFPDMIFVYTSITLKSRYITFNGVAIDMLNDSKFVAYKNSTIKLEVLSSFYISLYLCSFLSNSLITKLIKKYLSKYRENNLIDTTFDNLEYGDKLGYLDFVKYSTPLVYAEACENIVNFIAKSNYENRRVIHNMHSFTEKAYAKVIYCKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G540</accession>
    <name>A0A174G540_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">appA_4</name>
        <name evidence="5" type="ORF">ERS852471_01778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265756.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56000">
        <property type="protein sequence ID" value="CUO56000"/>
        <property type="gene ID" value="ERS852471_01778"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022262" evidence="3">
        <location>
            <begin position="29"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="84"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO56000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="568" mass="64410" checksum="FDA8FA9F462E1DD6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBY0</accession>
    <name>A0A174GBY0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265881.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59147">
        <property type="protein sequence ID" value="CUO59147"/>
        <property type="gene ID" value="ERS852471_01844"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883872at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="244" mass="27949" checksum="7D31F1D9B0A0E541" modified="2016-09-07" version="1">MKKHIDKILIFIAAIITGTLISISFGDSKVDTFFSMKSIEYKDAIEQRNLLYKEISDLKENNNEIMYKLRDYNQGEEKHQKVIDDMKLQLSDYSEIAGTTALEGSGIVIKIKDGYYDISESTSYEIDRRTLHATDAALLINELRAIGAEAIAINGYRVLNDTGVQCEWAFIGFNDNNQTIEGQPFYFYALGKPEELEAALFSDGSYLNRLIIRGLEIEVEKREDLYFPPTNRILDFQYMERADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGI9</accession>
    <name>A0A174GGI9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_01880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60677">
        <property type="protein sequence ID" value="CUO60677"/>
        <property type="gene ID" value="ERS852471_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016732">
        <property type="entry name" value="UCP018688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41373">
        <property type="entry name" value="PTHR41373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018688">
        <property type="entry name" value="UCP018688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="7">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO60677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="35017" checksum="07308C9D98910B53" modified="2016-09-07" version="1">MLDLHPISYKDKNLINYYSNFINTSSYEYSFNSLYLWKDLCKTNLTTIYDTLVIQKYDDEKGFFFMMPYYKNVESLYKTLDYLKSNYENYQYLLGDIDSDHIELLKNNYDLEILENKKSFEYIYLTSDLINLKGKKYHKKRNHYNNFINLYNYNYSSINNEKIIEDCLDLLNKWENKKCICSKELLIEPIAVKNILYSLDDLSLKSIALYVDNKLVGFSIGEKFKDSAIIHIEKCNANYRGVYAFINNEFLKTSFSDTIYVNREEDCGHEGLQKSKESYHPYKVLNKYFIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GI56</accession>
    <name>A0A174GI56_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265944.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60640">
        <property type="protein sequence ID" value="CUO60640"/>
        <property type="gene ID" value="ERS852471_01879"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1882521at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="178" mass="20907" checksum="B179F78F8FAF35EB" modified="2016-09-07" version="1">MSSINNKVLEEKIGQLKKAIEIVGGQEEIIDKWSNNDKIMNYIITKLFEEGKVTFNVCNKEYSINELLGIKLDYEKYFLKNKNKTIENIIYKIKKYDTSLDSLIRKYKKTRGIEEYNKMFSTLEKTYRRDINMIILREVDNVAVEALFAGEEEKYYGEYLNQKKKALLDGVISKMGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GN17</accession>
    <name>A0A174GN17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266058.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64042">
        <property type="protein sequence ID" value="CUO64042"/>
        <property type="gene ID" value="ERS852471_01943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="208" mass="23475" checksum="B0DB1839598C8C83" modified="2016-09-07" version="1">MKKIDKKTASLFIILLCFIIGGSLSFESLARFTKKFEIVNKKVSVATFEVSADSEFVSEAEIKPGDVLSADTIKLKNDNDYPVEFTISLSEKSENNNKDKSTSEGAKDLIKYLTLTIEGVNQTESKNHYTTIVNPNNEKVVSAKIEWITDDDIEIYENDILDNIARYTYDIKAKQVLVDDTIPPSTSDENKEIVFYKSDFGNTSYIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GP86</accession>
    <name>A0A174GP86_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capsular polysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="4">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">capD_3</name>
        <name evidence="4" type="ORF">ERS852471_01952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266076.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64394">
        <property type="protein sequence ID" value="CUO64394"/>
        <property type="gene ID" value="ERS852471_01952"/>
    </dbReference>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="292"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="635" mass="71632" checksum="F4C2F65AE9137E87" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPR6</accession>
    <name>A0A174GPR6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore coat polysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="4">2.6.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arnB</name>
        <name evidence="4" type="ORF">ERS852471_01953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.87" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266078.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64443">
        <property type="protein sequence ID" value="CUO64443"/>
        <property type="gene ID" value="ERS852471_01953"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099620">
        <property type="term" value="F:UDP-4-amino-4-deoxy-L-arabinose aminotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO64443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="395" mass="44658" checksum="07A1FE6B7F43E137" modified="2016-09-07" version="1">MGVELIKEKAKPKINKRIFLSSPHIGKYEKKFIDEAFLTNWIAPLGANVEGFEKELSEYVGIRGGLALSSGTAALHMAVKLLGVTKGDIVFCSSLTFVASCNPIMYEGAEPVFIDSEPESLNMSPVALENAFKYYEELGKLPKAVIVVHLYGQSADMDPIMEICNRYNVPVIEDAAESLGATYKGTQTGTIGKYGIYSFNGNKIITTSGGGMLVSDDTDGLLKAKFWSTQARDKARHYQHSELGYNYRMSNVVAGIGRGQLRVLEDRIKKKKEIYELYKYGFSEIEEIKMAPIRDYGDSNYWLSVVILDETSKIKPIDIILALEEENIESRPVWKPIHLQPYYEEYRFFKHNEDLEISVAEDVFNRGICLPSDTKMTIEEQEYVIEIIKNLFREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU84</accession>
    <name>A0A174GU84_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266060.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64075">
        <property type="protein sequence ID" value="CUO64075"/>
        <property type="gene ID" value="ERS852471_01944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="160" mass="18374" checksum="C06F376FE20C33EE" modified="2016-09-07" version="1">MKSQKLYFDAEIEILDELNNSKGNGFNLTVGIRDTLNEDNSNNFTYQFYKVKEDNKSNIFTRLTNNNGSNLQNVMYLKDNNDIVIDSEKLILIGEIELNGDETIVCNLIIKDYNSKTILYEKRLYGRKYSENNKIFINISGFCGGEGVKINSMEVKAKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GX70</accession>
    <name>A0A174GX70_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Primary replicative DNA helicase</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaC_3</name>
        <name evidence="2" type="ORF">ERS852471_01977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65379">
        <property type="protein sequence ID" value="CUO65379"/>
        <property type="gene ID" value="ERS852471_01977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14722" checksum="9A6D47E02A0F915F" modified="2016-09-07" version="1">MTNRIGRITGKFKDLALEEDICVVLVAQANRGVDKKSGEILLDRLSTSDIQDSVRIEQDSDQVIGLYRDLKLDDKAYRDFMLKKGKIDYYSMDADKNPNCINAIIMKNRHGEIGTSALKWEGKCSMVSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H187</accession>
    <name>A0A174H187_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">feoB_1</name>
        <name evidence="12" type="ORF">ERS852471_02046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266258.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68644">
        <property type="protein sequence ID" value="CUO68644"/>
        <property type="gene ID" value="ERS852471_02046"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <end position="245"/>
        </location>
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            <end position="286"/>
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            <end position="419"/>
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            <end position="474"/>
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        <location>
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            <end position="514"/>
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        </location>
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        <location>
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        <location>
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        <location>
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        </location>
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        </source>
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        <source>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO68644.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="671" mass="72609" checksum="E4843642BA193155" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H669</accession>
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        <name evidence="9" type="primary">phoR_10</name>
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        <dbReference type="NCBI Taxonomy" id="84024"/>
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    <reference evidence="9 10" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="668" mass="76775" checksum="8227C4D7B9E75408" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6U5</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ERS852471_02061</name>
    </gene>
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        <lineage>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69147">
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        <property type="gene ID" value="ERS852471_02061"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
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        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO69147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="210" mass="24734" checksum="A270B55F31EB85AD" modified="2016-09-07" version="1">MNSLSYLLETCPSHIKQDFLNITFNSFDKILFQNEAANSVYIIKKGKVKVYSLTPTGVKYLERIYCEYEIFGELEIFIDKPILNYVEALEPCEVIKIPKKSFLDWIRYDSDFSLYIHIQLSHKLYTTSINSKANIVYPLKYRLAFFLWRFLEEHDLDTIHKDLLVEGVGSNIRSVNRIIKELSNDNIIDYNKGHIKVKDINKLLDIIFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGT3</accession>
    <name>A0A174HGT3_9CLOT</name>
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        <submittedName>
            <fullName evidence="6">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266405.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72358">
        <property type="protein sequence ID" value="CUO72358"/>
        <property type="gene ID" value="ERS852471_02129"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO72358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="30684" checksum="783345041231603F" modified="2016-09-07" version="1">MIIFDGLYSFISLLLSMLSLFISNFMSKNDVEKFPFGKHILEPLVISIKSLVILIMCLYTLIDAVKIMFNGGNNIEFGLAIVYSIISVVGCGIITLYMKKKEKKLSSELIKAESNQWFMDTALSAAVLIGFLVAIVLSKTTLSFLNPYIDPTMTLIVSIIFLRLPIKTFIESFKEIISVKADDEINDDIYVLVKEIEEEYKFEESIARVSKIGRELRIEIDFVYNQNSKLKTLDQMDSVREEINDAIKHIKYNKWLNVSFTGNKKWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHU0</accession>
    <name>A0A174HHU0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266480.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73791">
        <property type="protein sequence ID" value="CUO73791"/>
        <property type="gene ID" value="ERS852471_02168"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815957at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="23577" checksum="9730F8EDB256D095" modified="2016-09-07" version="1">MIGTIVNSVAVVIGCLIGFIIKGRLKTNISNTIMSGLGLCVLYIGVSGALKGEDTLLMIICIVIGALIGELIDIDKWLSRLGEIIERKVNKVGKSNISIAEGFVSASLLFCVGAMAIVGSLESGLRGNHDTLFAKSLLDGVTSIILTSTLGIGVIFSAVTIFIYQGLITLGAGMLANVLSESVINNMTAVGSLLIIGLGFNILGITKIKVANMLPAVILPVLLGVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJR9</accession>
    <name>A0A174HJR9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin cobaltochelatase</fullName>
            <ecNumber evidence="3">4.99.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiK</name>
        <name evidence="3" type="ORF">ERS852471_02164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.99.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266474.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73666">
        <property type="protein sequence ID" value="CUO73666"/>
        <property type="gene ID" value="ERS852471_02164"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100154at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033579">
        <property type="entry name" value="Anaer_Co_chel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO73666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="32051" checksum="7D0B87C625FE7D61" modified="2016-09-07" version="1">MKRAVLIVSFGSSNLDAYKQVESFIKNIKDSIDKELFIQCVFTSNILIKRMKEKNNIDILNVKEALEILFNDGYKEVILQPLHMIDGKDCDSLRNILEENKDRFNYIKLNPTLLINKGKNTKESALNIANAIKDNVNKDRCVVLVGHGSNRCQDNCCYTSIGINQCCGDNGNVCNDDCYQEIEKALQSIGYKNVIIGTLEGSRTRSVVLKELKDKKIDDVIIMPLLVLPGNHIIKDIKGDNSWESLFNENDINVEVNLKSLLEYEKIQKLYIDMINEAINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKA0</accession>
    <name>A0A174HKA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZupT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">zupT_2</name>
        <name evidence="6" type="ORF">ERS852471_02166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266476.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73727">
        <property type="protein sequence ID" value="CUO73727"/>
        <property type="gene ID" value="ERS852471_02166"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="259" mass="28089" checksum="C2D54E1A7BD0D93E" modified="2016-09-07" version="1">MIDKNSLFPLILSSIAGLSTVIGAVLVFFTKTKNNRFLTFSLGFSAGVMITVSFTDLFPAAQEAISKYHGKANGILWSILFMLIGALMAFLIDSFIPDEEKSQVPKDDKNFGLFRVGLVSTIALMIHNFPEGIATFVSGYQDAALGISVTLAIALHNIPEGIAIAMPIYFATKSRAKALKYSFLSGMAEPLGAFISFLFLKPFINDLVLGIVFAVVSGIMMYISFSELIPSSREYGHIKLSLASIFLGVAIMPITHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HSU0</accession>
    <name>A0A174HSU0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_2</name>
        <name evidence="2" type="ORF">ERS852471_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266584.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76140">
        <property type="protein sequence ID" value="CUO76140"/>
        <property type="gene ID" value="ERS852471_02235"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="242" mass="28498" checksum="3F44ABD29EDE5F70" modified="2016-09-07" version="1">MNSIDKNLKTPLYLQLVNILVEKIEKNMEEHEQILSEREICDIYDVSRTTVRQALDQLEKEGYIYKVHGKGTFVSPKRLNQDLISFYSFTEEMKKLGKKPNSEVVGFEIIRAEEKISRMFKISDDELVYKITRIRKADDIPMMYETTYLPYNLFIGLSKDKLEIMPMYDVLVNEFSAKLTSAEEYFEPIITKKLESIYLEIPEGAPSLRIERFTYDHDTLIEYTIGIARGDKFKYRVQLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTV0</accession>
    <name>A0A174HTV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybutyryl-CoA dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
            <ecNumber evidence="2">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crt</name>
        <name evidence="2" type="ORF">ERS852471_02244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EC" id="4.2.1.55" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266603.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76470">
        <property type="protein sequence ID" value="CUO76470"/>
        <property type="gene ID" value="ERS852471_02244"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003859">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="28367" checksum="57ED0BCC1C513851" modified="2016-09-07" version="1">MQVDVELKNVIFETEGNLATITINRPKALNALNSDTLRELDIVIDSIENNSDIYCVIVTGAGQKAFVAGADIAEMKDLNSTEAEEFGLLGNKVFRRLETLDKPVIAAIPGFALGGGCELAMACDIRIASEKARFAQPEAGLGITPGFGGTQRLPRLVGAGKAKELIYTCAMINAEEALRIGLVNKVVPVESLMDEAKKMAGSIIANAPIAVKLCKDAINRGTQVDIDSAIKVEAEDFGKCFDSEDQLEGMTAFLEKRAKNFQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HY62</accession>
    <name>A0A174HY62_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SpoOJ/ParA/ParB/repB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266685.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78566">
        <property type="protein sequence ID" value="CUO78566"/>
        <property type="gene ID" value="ERS852471_02292"/>
    </dbReference>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO78566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="48426" checksum="20048ED65DD94B7A" modified="2016-09-07" version="1">MAIIRPFRAYRPVNDLVEYVAAPPYDVVNSEEARALVKDNKYSFLRVDRGEVNLSKDIYKYDDRVYECSRDLLDSMIKEGIYIQDKEPMFYIYRQIMNGKNQTGLVICASIEEYIENKIKKHENIRDDKGIDRVKHIKYCNAHTGPIFLVYRENKSITDIINKYIKLNPIYNFVADDNITHVVWKIDNKDDIKYITESFYNIENLYIADGHHRIEAAARVAMENKKNNNKDNFNDEINYFLAIAYPDSEVNILDYNRTIKDLNGYTKKEFLEEVSKKFKIKKSDNNKPVSPERKHTFGMYIDKEWYILEANREIINEKVKSEELDVSILQNNILAPILGIDNPKKSDRIEFIGGIRGLKELEKRADTDMAVSFSLYPIEMSDIMSIADEGGIMPPKSTWFEPKPRSGIFIHKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HYU1</accession>
    <name>A0A174HYU1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">plsC_1</name>
        <name evidence="5" type="ORF">ERS852471_02318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266723.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79391">
        <property type="protein sequence ID" value="CUO79391"/>
        <property type="gene ID" value="ERS852471_02318"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="74"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO79391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="240" mass="27154" checksum="AF2F52F9D46444DA" modified="2016-09-07" version="1">MIRTIIWFIWFAISLIISIPFVFRVNYLIKKDRIEESKKLIHKCTSLWAKSLLKIAGVKINVNGIENIPNDKTVLFIGNHQGNFDIPIYLSTMPILIGFVAKIETEKIPLVRTWMRLMKCVFMDRSSLRKSSEAIIHGIKNLKAGYNMVIFPEGTRSRGDKTGEFKAGSFKLATKSKVPVIPVTMNGSYKIMEHGNGPWIKPANVDLTIHAPIDTSSLTKEEIDNLPSKIEEIICSKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4A5</accession>
    <name>A0A174I4A5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage 0 sporulation protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spo0J</name>
        <name evidence="4" type="ORF">ERS852471_02363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266794.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80856">
        <property type="protein sequence ID" value="CUO80856"/>
        <property type="gene ID" value="ERS852471_02363"/>
    </dbReference>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO80856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="33679" checksum="5A059569FEFFB792" modified="2016-09-07" version="1">MSKKFGLGKGLNALIPEDTNLGPSINKIEKKTSDKNLIDINLIRSNIDQPRKTFDDEKIIELSESIKHHGIVQPIILRKEEDNYVIVAGERRWRAAKMAGLKEVPSIIMDLTDKQVLEISLIENIQRQDLNSIEEAMAYKKLISDFDLTQEELSKRIGKSRVAITNTIRLLNLGEDVQQYLIEGVISEGHGRTLLGISDKKLQYELAQKVIDDKLSVRELENIIKRIKKDVDNSSKKKSETELTNPYYKDIVERLQNYFGTKVNLSNKNNKGKIEIEYYSEEDLQRILEIIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I5A0</accession>
    <name>A0A174I5A0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266840.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82313">
        <property type="protein sequence ID" value="CUO82313"/>
        <property type="gene ID" value="ERS852471_02387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO82313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="108" mass="11865" checksum="23AE1FEE97B23747" modified="2016-09-07" version="1">MQTGAKISQFGHHAEAICTGSLAGHNAVRLMLGMPLLILPASIAIGDLIGYANEKAATREGRMNRYTFAGAGYLKRMEELGLYTTDINEINNRIKKVNLDNIFEQKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGV0</accession>
    <name>A0A174IGV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desK</name>
        <name evidence="3" type="ORF">ERS852471_02436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266924.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84179">
        <property type="protein sequence ID" value="CUO84179"/>
        <property type="gene ID" value="ERS852471_02436"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO84179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="367" mass="42403" checksum="3A8E7F61F42A1EA4" modified="2016-09-07" version="1">MELKHISIKVKLIIFVYMLLSITKMQKIDKSLIILMLLYLISIFSNGIVKEKYRIILSAFEGLCALFIGIKFIPIAMVLLIITMLELALGKIKDKGILFALIALPLLLIRDYLLNSEIIVLVLVIALFFSYYFKEQHNLFKMERENEQRRKEIYKLQSRLKEEQNFKEQFLYTMQLEERNKLSGKLHDRIGHTISGTLLQLEAIKLTIDNNKEQGKKLLDMSIDNLRKGMNDIRMILREIRPQQEELGINRIKLILEEKTKNTRFKYSIRHSGDLEKISASNWIIFVQAVKELSTNSIKYSKGTEIDVNITILNKIIKLEVRDNGIGSMEVKKGIGLSNLEEKIAEINGQLIVDGTDGFSVILIIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IV95</accession>
    <name>A0A174IV95_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267100.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88885">
        <property type="protein sequence ID" value="CUO88885"/>
        <property type="gene ID" value="ERS852471_02542"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="532" mass="58996" checksum="F7B0509ED18EDB45" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J2R4</accession>
    <name>A0A174J2R4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yjcD</name>
        <name evidence="9" type="ORF">ERS852471_02652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267297.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93963">
        <property type="protein sequence ID" value="CUO93963"/>
        <property type="gene ID" value="ERS852471_02652"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="272"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO93963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="664" mass="77378" checksum="424E4A96910DB6BD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JB39</accession>
    <name>A0A174JB39_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hemN</name>
        <name evidence="5" type="ORF">ERS852471_02712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267409.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96904">
        <property type="protein sequence ID" value="CUO96904"/>
        <property type="gene ID" value="ERS852471_02712"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO96904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="376" mass="43773" checksum="C94BC8D667AAAC0F" modified="2016-09-07" version="1">MKEISLYIHIPFCKQKCFYCDFPSYSGKERFKEDYVDALIEEIEKRARGYIIKTIFIGGGTPSYLEVNQIEKLLLAINKLNLHKDIEFSMECNPGVLFKEKLIAMKNGGVNRISFGLQSTKDSLLKEVGRIHSYEEFLDNFKLARELGFKNINVDIMYGLPNQTVEDWKDTLETICSIKPEHISAYSLIIEEGTVFYNLYEKGLLKLPTEEMEREMDKLTKGVLKDHGYHQYEISNYSLDGKECEHNKVYWQLKDYIGLGTAASSYIDGTRIKNIDNIEEYISKINSGIEVYEEKYINSEEDEIEEFIFMGLRMNKGISIKEFEERFNMSVESIYEKVLEKNIKNGFLKKENGRIYLTSIGMDFSNNVMAEFILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBF3</accession>
    <name>A0A174JBF3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoVAC</name>
        <name evidence="2" type="ORF">ERS852471_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO95971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95971">
        <property type="protein sequence ID" value="CUO95971"/>
        <property type="gene ID" value="ERS852471_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014203">
        <property type="entry name" value="Spore_V_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02838">
        <property type="entry name" value="spore_V_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO95971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="157" mass="17002" checksum="54764480DE99CD7E" modified="2016-09-07" version="1">MADISKKEEKILNEFQDLSKQAKPKPKYFKNIILAFIVGGIICTIGQFILNMLIKYGIPEEEAKKWLPVIMVFLGALLTGLGVYDKIATFGGAGTVVPITGFANAMVAPAIEFKKEGFVFGVAAKMFTIAGPVLVYGIGTSVLVGLVYYVLKLFGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JC64</accession>
    <name>A0A174JC64_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">V-type sodium ATP synthase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267332.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94709">
        <property type="protein sequence ID" value="CUO94709"/>
        <property type="gene ID" value="ERS852471_02669"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2049718at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014275">
        <property type="entry name" value="ATPase_A1A0-cplx_hsu"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02926">
        <property type="entry name" value="AhaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO94709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="108" mass="12037" checksum="4B7E621B7A9B5C2D" modified="2016-09-07" version="1">MALEAIKEIKNAEQKADEMINEAKKNAAEMIQKAKSEADSKYNEILKEARAKADEIINLAIEEGNFEAKPILEKGEKEVYAIKNVANDVKENAVNIVVERIVKSYGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JLI3</accession>
    <name>A0A174JLI3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnC_2</name>
        <name evidence="5" type="ORF">ERS852471_02796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267555.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00644">
        <property type="protein sequence ID" value="CUP00644"/>
        <property type="gene ID" value="ERS852471_02796"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP00644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="17407" checksum="E7F7DFCBA6D7990E" modified="2016-09-07" version="1">MNQSYQLDELDFQILDILVKDCRTPYLEIARLCHVSGGTIHVRMKKMEELGIIKGSRILLDLPKLGYDVCCFVGIYVDKTSSFNDVFDELSKIKEVVELHLTTGDYSVFAKVICKNITDLQDILLNKINVITGIQRTDTIISLNQPIDRNITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JNH9</accession>
    <name>A0A174JNH9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ORF">ERS852471_02786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267538.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00181">
        <property type="protein sequence ID" value="CUP00181"/>
        <property type="gene ID" value="ERS852471_02786"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="448"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP00181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="563" mass="64040" checksum="952CA7CECEA8E634" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQX2</accession>
    <name>A0A174JQX2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mutator mutT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP01031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267574.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01031">
        <property type="protein sequence ID" value="CUP01031"/>
        <property type="gene ID" value="ERS852471_02805"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971530at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP01031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="126" mass="14661" checksum="70711953551AB21B" modified="2016-09-07" version="1">MEKVLRCSILIVDDFNNVLVAERGKGKGATKTWGLFGKEIKGKEDEEKCITKAVDKDIKCNIFDLKPFKEYFDEKDNGLKVFIGSIKEYITCHKSINQVKWIGKNDIDKYEFNQEDIKILKDFFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQZ5</accession>
    <name>A0A174JQZ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">whiA</name>
        <name evidence="6" type="ORF">ERS852471_02819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267609.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02152">
        <property type="protein sequence ID" value="CUP02152"/>
        <property type="gene ID" value="ERS852471_02819"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1634356at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="5">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP02152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="35733" checksum="A2789273D788C5F5" modified="2016-09-07" version="1">MSFSSKVKGEICRYIEISKEEALAEISAIMKVSGTIGFSGKGLSFKITTENPASARHIFTILKDYFDIHSKLLVKKSNSLKKNNIYMVLIEEDMGVRELLKETGIFKEVDDVLTIDYTIEPEMVKTEELKRAYIRGAFIGGGSISNPEKTYHLEFVTHSEEYAIQLCKLINSFGLSSKVIQRKNSHIIYIKEGEQIVDLLNIVGAHTSLLELENIRIMKEMRNNVNRLVNCETANLSKTVNAAVRQVESIKLIQSTIGLQRLPKNLREVAELRLSYPDESLKELGEMLNPPVGKSGINHRLRKIEKIAEEVRSGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZN4</accession>
    <name>A0A174JZN4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ/DHR/GLGF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267625.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02665">
        <property type="protein sequence ID" value="CUP02665"/>
        <property type="gene ID" value="ERS852471_02829"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1818090at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP02665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="420" mass="46416" checksum="76078A83518C5060" modified="2016-09-07" version="1">MDLIIYTLKSVATAIVEPLHLLMLIIMGIMFYLKNRRISIVQKMTLGESLDSPLELTLSQIVLGIIAGALGSLILSLLGVTFYENSGIEFVFMISILMLFYKPKFVEFAYSSAILAILSLVFNILASLINQKSLISVDILSLMTFVGVIYIIQGILIIIDGSRGAIPVFTSKEGKIIGGFSLNRYWALPIAIFMIFNNQISSGTTMTAPNWWPIINHTNILSILTTAMIATIPFYGVIGYNAVTFTKKKKEKSLSSGAIALLYGISVICVAQISGFGIVGQILTIIYVPLAYEGILRYQRRIEAKGEYIYVSDEEGISVLEVAPSSPAFEAGIRRGDKILAINDEVVKSETDIFKLAKDSIFKLKIRIKKDAGNVVEYLVQPRNKRLGILLVPKMVKQEDILGVGADDLKKVLEELREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEC5</accession>
    <name>A0A174KEC5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_4</name>
        <name evidence="5" type="ORF">ERS852471_02968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267876.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08796">
        <property type="protein sequence ID" value="CUP08796"/>
        <property type="gene ID" value="ERS852471_02968"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP08796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="27046" checksum="D64E875BDF1F27F1" modified="2016-09-07" version="1">MDYAIKVEKLSKNYQSYVAVDNLSFEVKKGTVFGLLGANGAGKSTSIECILGTKKIDKGEVSILGLNPISNRKELFERVGVQFQEANYQENIRVEELCEVTASLYKNPANYKELLQRFGIEEKSKTLVKEISGGQKQRLFIILALIPNPEIVFLDELTTGLDARARRDVWQILKDLKEKGLTIVLTSHFMDEVEVLCDIICILKKGKVVFHGTVKEAIEASPYEKLEDAYLWYTDEEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLE8</accession>
    <name>A0A174KLE8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10435">
        <property type="protein sequence ID" value="CUP10435"/>
        <property type="gene ID" value="ERS852471_02999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="46" mass="5494" checksum="CFFED48BD4DB8D0F" modified="2016-09-07" version="1">MIIVALIILFYLAIIIGSICLLIWAITTRIKEKKREEIEHKDYKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KMS4</accession>
    <name>A0A174KMS4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yncA</name>
        <name evidence="2" type="ORF">ERS852471_03028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267998.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11447">
        <property type="protein sequence ID" value="CUP11447"/>
        <property type="gene ID" value="ERS852471_03028"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="23388" checksum="F1223F7D5F96BF41" modified="2016-09-07" version="1">MDKSIKYYEVLMIRRNSEFFRKYKLPVGYTIKPYEKGMEEEWSKLQTEVGEFKDVSDAKRYFEDEFIKENVDLSNYCYFVESPKGKVVATASLWFGKHFDEGIKYRLHWLSVHPDYRGKGLGKALISYILKNEKLKGEKYVYLKTQTWSYKAIALYLKFGFKPYSGIKPDNWDCCHMDFENYNNEAWELIWSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L3N9</accession>
    <name>A0A174L3N9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Staphylococcal protein of uncharacterized function (DUF960)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268244.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18773">
        <property type="protein sequence ID" value="CUP18773"/>
        <property type="gene ID" value="ERS852471_03165"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065258at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009303">
        <property type="entry name" value="DUF960"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06124">
        <property type="entry name" value="DUF960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="103" mass="12441" checksum="382BD443193AD678" modified="2016-09-07" version="1">MFKKDNRYVTREVNEEVDIRLQLIMWSMIDKLKDEENVELDYLQVFRIRKEGKNIVISQSQEVPEYSCTYEIELEDIQIDDEIKLYVIDNGVEGSIILFPWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L9R6</accession>
    <name>A0A174L9R6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sphR</name>
        <name evidence="9" type="ORF">ERS852471_03203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268311.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21012">
        <property type="protein sequence ID" value="CUP21012"/>
        <property type="gene ID" value="ERS852471_03203"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="225" mass="26349" checksum="47C9FC20B7444E3D" modified="2016-09-07" version="1">MNSRILVVEDDNQIQELIVEFLSSQDYIVDTASDGIEGYEKFKNGNYDLVMLDVMMPKLDGYGLCKMIKRLDENVPIIFLTALGDEESEVRGFELKADDYISKPFSFNILIKRVEAVLRRNKKEKNESDILEFEKLRLELQTFKAYVNNEEIELTLKEFNILALMINSYPMVVSREMLIEKIWGYDYFGDTRVIDAHMKNIRKKIQKDYIKTIKGVGYVLEKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L9U4</accession>
    <name>A0A174L9U4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268234.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18525">
        <property type="protein sequence ID" value="CUP18525"/>
        <property type="gene ID" value="ERS852471_03159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="14626" checksum="05C92D6846498A96" modified="2016-09-07" version="1">MDKELVDIISDLKNELRVITERINSIERVVLADKKNMTEDQCINKSVEDTGDVGKFFDEVYKNINDHIKYKTWIETNVKTTIIKEDTIIIRCVNSFNYDILKKRYYDLLRKSTKYKVVIEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJE5</accession>
    <name>A0A174LJE5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_3</name>
        <name evidence="7" type="ORF">ERS852471_03238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP22836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268376.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22836">
        <property type="protein sequence ID" value="CUP22836"/>
        <property type="gene ID" value="ERS852471_03238"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP22836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="33732" checksum="82DF277669BA0F69" modified="2016-09-07" version="1">MKKNKTMIVAFITPAILTFCIMFLYPVIRTVFISFYSVSSVTAPKEQWISVGLGNYLKLLTSSSFKVSMMNIFKIWVVGGAIVLTISLLFAVILTSGVRFKSFWRAAIYLPNVISAVALATMWLQFVFQQKYGIINWFFKAMGNEKLARLNWLASDMKFWAMLIAFCFGAVGYYMLIFLSGIERIPEEYYEAATIDGASKLRQFTSITLPLLKGVFKTNLTFWSINTVMFFVWSKMFSPLGAEGSTITPMVYMYETVFGGTGYSNRDAGLGAAVGVTLAIIVVIIFAVMNLLIKEEKIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LK99</accession>
    <name>A0A174LK99_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L7AE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rplGB</name>
        <name evidence="2" type="ORF">ERS852471_03226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268350.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22235">
        <property type="protein sequence ID" value="CUP22235"/>
        <property type="gene ID" value="ERS852471_03226"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2081820at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP22235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="8507" checksum="31EAE83A177DF646" modified="2016-09-07" version="1">MLDKIVGKKVIGVKQCQKLIRNGKVLYVAKDAISKLVLPLIELAKENNVEIVEISTMKELGKMSGIDVKSAATLVLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LLZ8</accession>
    <name>A0A174LLZ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZIP family zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">zupT_3</name>
        <name evidence="6" type="ORF">ERS852471_03254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268405.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23637">
        <property type="protein sequence ID" value="CUP23637"/>
        <property type="gene ID" value="ERS852471_03254"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP23637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="28484" checksum="A37B8ACBD9EBE9F9" modified="2016-09-07" version="1">MEWFMNLNPVLQGLFATIFTWAITALGAGLVFFFKSVDRRILNTMLGFGAGVMVAASFWSLLNPSIELCTELGYSEWMLPAIGFFAGGVFIILADKMMDKYSYGVITKSDETSVDSIAKKYKKSILLVTAVTLHNIPEGLAVGVAFGGVAAGIPSASIGAAITLALGIGLQNFPEGAAVSLPLRRDGLSVGKSFLYGQFSGLVEPVAGVLGAVAAITVRSMLPFLLAFSAGAMVAVVGSELLPEASIENKNLTTIGLIVGFITMMILDVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LPN0</accession>
    <name>A0A174LPN0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="10">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycogen branching enzyme</fullName>
            <shortName evidence="10">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">glgB_2</name>
        <name evidence="10" type="synonym">glgB</name>
        <name evidence="13" type="ORF">ERS852471_03272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000037">
        <property type="protein sequence ID" value="CUP24941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24941">
        <property type="protein sequence ID" value="CUP24941"/>
        <property type="gene ID" value="ERS852471_03272"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="199"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP24941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="682" mass="80827" checksum="B94513399E307E3D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M0M4</accession>
    <name>A0A174M0M4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Capsular polysaccharide biosynthsis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cap8A_7</name>
        <name evidence="9" type="ORF">ERS852471_03313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000043">
        <property type="protein sequence ID" value="CUP27520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268489.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27520">
        <property type="protein sequence ID" value="CUP27520"/>
        <property type="gene ID" value="ERS852471_03313"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP27520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="224" mass="24967" checksum="6A793906301E2001" modified="2016-09-07" version="1">MEEHIISIEEIFEALKKRWKMIALITILATVVSGIFSFFVIKPAYEASTKVFIGKEESSEEGYNSNDIAMYQKLLKTYSEAIKTRDLLTSAIKDTEYDVTPGEVASGLTVTPVSDTQILQIKYKSLDPEEAAVILKSITTNFIKTAKELVPNGNVRVIEAVETPKNPVSPNKVMNIAIAFILGLMVSIGLVFLLEYMDNTYKTKEQLENELEIPVLGVIPNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XAI4</accession>
    <name>A0A173XAI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262666.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48799">
        <property type="protein sequence ID" value="CUN48799"/>
        <property type="gene ID" value="ERS852471_00001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="356" mass="38396" checksum="4F8F2F4AEDAB5BD8" modified="2016-09-07" version="1">MSQIKSTRSKWKAIEMVGLFLVILSFIVLLVSPDSLSGLFDSITKQVFPIVVDVFLLSEVGVAIIISVIVGRILERLGFTDALIRIFIPIMKFFKINPSVIIPSVYNVLGDINAAGAIAGPVLVKAKATKGEQKIAIATMIQSPQSFATLVLGLVVLTKFNIKALPLVIVAVFLPIILVPLILSKTVYRDTKAVDLEELPRFTPETKFLDTLFSSAKEGAYLLFLVIIPAVAAVFTMIGILDYFGIWAIISNAMTTCLQWLQIEPATGIVSILASPTLAMAQLAEMSNVAPALIVGGFVLANSGFPLSVLFGQIPVTWKEHSDLNEKEALYAALLGAAIRLVSCLIIALVLTPFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQ77</accession>
    <name>A0A173XQ77_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">azoR2</name>
        <name evidence="6" type="synonym">azoR</name>
        <name evidence="8" type="ORF">ERS852471_00091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262813.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53723">
        <property type="protein sequence ID" value="CUN53723"/>
        <property type="gene ID" value="ERS852471_00091"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1402654at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN53723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="25107" checksum="6E698E1D26CB9EBA" modified="2016-09-07" version="1">MSKKLLYISVNSKPENLSSSKSVARDFINKFLDKNKDFQVEEVDLYKQHIPRLEYQYFESRNCIINEEAEKKLPEKEQKEVQRIRELCDQFISADMYVIASPMWSVSFPASLKEYIDCIVQVNKTVLIEKDKKPKGLLDDKKRALVYIQSSGGSIPWILDPVMDKGENYIASIMKLMGIKTVVELKVDGTGTTEEERQNAINKAKEKIDDIIDGLDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XV08</accession>
    <name>A0A173XV08_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262869.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55100">
        <property type="protein sequence ID" value="CUN55100"/>
        <property type="gene ID" value="ERS852471_00121"/>
    </dbReference>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN55100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="22753" checksum="6697EF237799095A" modified="2016-09-07" version="1">MSNSNFSRNIGILMSLIIIALGLLYMCSTFGSRAYFTLSSYLVILLLYIVIKKVISFSYKSRDYDLLQYSVSVVIVVEGEDSEALVRLVKNLLNQDYPLKEILIINTNSKNLNIYYMAKKIRKQIELFKESGIKGEIDLGDIKSCPEIIIKKTSRNEDKSSAETWGFTRSTGDIVLTCNTNSIIDNDGIKELIKSAEDSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAT4</accession>
    <name>A0A173YAT4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide transport system, ATP-binding protein OppF</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">oppF_1</name>
        <name evidence="5" type="ORF">ERS852471_00230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263070.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60773">
        <property type="protein sequence ID" value="CUN60773"/>
        <property type="gene ID" value="ERS852471_00230"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN60773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="270" mass="30663" checksum="FE9A34DC5FCC1DF0" modified="2016-09-07" version="1">MSDTTSLCLSGNGITKIFGIGDSKTIAVDHVDFEFHEGEIISIVGESGSGKTTFAKMLLGLISITEGEILFQGKPRDIKTHKKKKEYWRGIQAIFQDPFSSFNVFNKIDSVLLDCINMRGGRKLSKEKKIKMMTEACSFVNLKFVELTNKYPFELSGGQMQRLMIARIFLLKPKILLADEPTSMIDACSRATILDMLLKLREETNMTIIFITHDIGLAYYVSDKVYIMEHGKFVEYGSAEDVILRPKAEYTRRLISDVPKIYEEWDLNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBA5</accession>
    <name>A0A173YBA5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xanP_1</name>
        <name evidence="8" type="ORF">ERS852471_00224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263059.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60426">
        <property type="protein sequence ID" value="CUN60426"/>
        <property type="gene ID" value="ERS852471_00224"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1419334at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN60426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="46849" checksum="00527C3346E08795" modified="2016-09-07" version="1">MNCKKENMYRLEGRVPLQDAIPLGMQHVLAMYAGNLAPLLVVTGVLNINTNVKVILLQNAMFVAGLITLIQLYPIWKIGSGLPVVMGTSSGFIPVSISVGTQFGYSAIMGASLLGAIMEFLLGFIIKPLRKILPHVVTGTVVLILGISLIPVGIQFIGGGVGLQSDPSFGSIANIVIGLIVFLVIIALKQFAKGFWSISSILIGVIVGYIIAVVFGMVDFTGVAEAAWFSIPKPIFMIEGLSYTFKIEAIIPYLLVYLATTVETIGDNTGIAVGGLGRDITDNELEGAVHADGFGSAVATLFGIMPNTSFSQNVGLVAMTKIVNRFVLMTGAIFLILCSFIPKLGAIVASIPNCVLGGAVLLMFAMISISGLNLLIEEGKISERSGLIVAASCAVGLGLSNCPEVMQHLPSWFQSMFGQAIVGGFVTATVLNLILPKDILNIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJ28</accession>
    <name>A0A173YJ28_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein implicated in regulation of membrane protease activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263133.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63789">
        <property type="protein sequence ID" value="CUN63789"/>
        <property type="gene ID" value="ERS852471_00251"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951939at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN63789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16003" checksum="81F66D2BB89AA376" modified="2016-09-07" version="1">MLDVIIWLVVAVVAIIVDIVTSSFIFMWFSIGALVAIILSFFGISMALQFIVFLITGIVLIAVGYPWAKKKFKVEKNHTLTMEQAYIGRVMKANEDIVEKSKIKVDGIYWTAYNKGKKISKDDQFVIVGIEGNKLIVELKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM60</accession>
    <name>A0A173YM60_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 5-hydroxyuridine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ho5U methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trmR</name>
        <name evidence="5" type="ORF">ERS852471_00277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60524"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="Rhea" id="RHEA-COMP:15591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
            <dbReference type="ChEBI" id="CHEBI:143860"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263177.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65212">
        <property type="protein sequence ID" value="CUN65212"/>
        <property type="gene ID" value="ERS852471_00277"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02217">
        <property type="entry name" value="TrmR_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043675">
        <property type="entry name" value="TrmR_methyltr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN65212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24354" checksum="57BF0B4E6187DCB2" modified="2016-09-07" version="1">MSGITYDYMEGYIRSLIPESEGKIKELEDFAEENKVPIAQKETIKFLEFMVGMKKPLRILELGTAIGYSAILMYEAAGTNPHITTIERSEEMIGFAKKNIESFGLEKNITIEAGDCLDVLERLEEPYDLIFMDAGKGHYNHFLPHCLRLLKEDGIIIADNVLFRGMVASDDLVKRRKITIVKRMRTYLEMVSNDKNLVTSVIPMGDGIAITRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPX8</accession>
    <name>A0A173YPX8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ORF">ERS852471_00288</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263197.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65729">
        <property type="protein sequence ID" value="CUN65729"/>
        <property type="gene ID" value="ERS852471_00288"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN65729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="150" mass="17728" checksum="BBC809181B900EC3" modified="2016-09-07" version="1">MKCPFCGFDESKVVDSRSTDDNTTIRRRRECANCSKRYTTYEKIEDIPILVIKRDSTRENFNKEKIVNGLIIACQKRPISRRQIEDIAEDIEKSISNKMLTEVETKLIGEMIMERLKKIDEVSYVRFASVYRQFKDINTFLEEIKNLMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YS04</accession>
    <name>A0A173YS04_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigE</name>
        <name evidence="9" type="ORF">ERS852471_00285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263191.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65588">
        <property type="protein sequence ID" value="CUN65588"/>
        <property type="gene ID" value="ERS852471_00285"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014200">
        <property type="entry name" value="RNA_pol_sigma-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02835">
        <property type="entry name" value="spore_sigmaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN65588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="27099" checksum="E2E5FE7D0293E411" modified="2016-09-07" version="1">MRKIILLLNKILSKFNLFAKKVFYVGGNDALPPPLKKDEEEELVEKLMTGGSEIRDILIERNLRLVVYIARKFENTGVGVEDLISVGTIGLIKAVNTFNPDKKIKLATYASRCIENEILMYLRRNSKVKAEVSFYEPLNIDWDGNELLLSDILGTENDTVYNLIEDEVDKQLLFLALKNLNEREKEIVKLRFGLDGYREKTQKEVADMLGISQSYISRLEKKIINRLKKEINKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0B1</accession>
    <name>A0A173Z0B1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comM</name>
        <name evidence="3" type="ORF">ERS852471_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263307.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69189">
        <property type="protein sequence ID" value="CUN69189"/>
        <property type="gene ID" value="ERS852471_00350"/>
    </dbReference>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="211"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="508" mass="57850" checksum="064DCB55F82AED8A" modified="2016-09-07" version="1">MAIKIISATHRGLDGVLISVEVDIMKGLPTFNIVGLPDASVRESKERVRAAIVNSGYEFPLGRITINLSPADVRKNGTLLDLPIALGILMESNQIIKRDLEKFIVFGELSLSGELVGIKGAIPIIFEGDSKKKKNYIFPLDNLSEMRHFTLGNFYPFKSLEQVVSFITNEDLLPYKNRKQINKGKEKFKLDFGDIIGQYTAKRAMEIVAVGRHNIFLFGSPGSGKSMLAKALPSILPPLTIEEQKEIAKIYSVSGLWNKGYFIERPFRAPHHTTTKTALIGGGNEIKVGEITLAHNGVLFLDEILEFSNELLEVLRQPLEDGIINISRLRENYTLPSKFILVGAFNPCKCGRFMEDENNSLCECTEYEKRRYLNKISRPLMDRIDLFNYVPRIKYEEITDKKDYIDSDKMRQKVLEAVERQSFRLKDTIYNYNSEIVGKDVFRICNISSKGKKVLEQYYNKYNITLRGYVKIIKVARTIADLECSDEIADYHIIEALQYRKNAFGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z995</accession>
    <name>A0A173Z995_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphotransferase system, lactose/cellobiose-specific IIB subunit</fullName>
            <ecNumber evidence="5">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">licB_1</name>
        <name evidence="5" type="ORF">ERS852471_00410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263413.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72467">
        <property type="protein sequence ID" value="CUN72467"/>
        <property type="gene ID" value="ERS852471_00410"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846001at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN72467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="11232" checksum="266207A81443BA9E" modified="2016-09-07" version="1">MKIVLVCLNGMSTGDLVNKMNKISIEKNLDLDITGVGYTDIVKEIDGASVILLGPQVKHYIRKVREMAEPKEIPVQIIDHITYGMRNADKVIDLALNIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHZ5</accession>
    <name>A0A173ZHZ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263499.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74838">
        <property type="protein sequence ID" value="CUN74838"/>
        <property type="gene ID" value="ERS852471_00456"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="19813" checksum="16AAAC0BB1184ACF" modified="2016-09-07" version="1">MIELLKTRRSIRKYEDREIEKEKLESILKAGLLSPSSKGRKPWEFLVIKDKEKLEKLSTSKPGGSLWLADAPLAIVVMANKEITSDVWIEDASIAATFMQLEAHSLGLGSCWSQVRERNYDNNLSSEDYVRKLLNIPNKYGICCIISIGYPGENRPSYEEKDIDFTKVHYEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5G3</accession>
    <name>A0A174A5G3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YhhN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83754">
        <property type="protein sequence ID" value="CUN83754"/>
        <property type="gene ID" value="ERS852471_00556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN83754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="229" mass="25221" checksum="45164540EEB313C7" modified="2016-09-07" version="1">MTNIIVLIFILVFDVCYMFGGGLPAKSIASIMFVGAGVINLVYCFKNKNNLKFPIWMIVALVCAMLGDILLVLNFYLGTAVFALGHIFYLVSYCMLETINIRDLICGICISLISVTIILFTPFLDFGGSLMQSVCCTYAIIISFMVGKAISNLLKEKNQVNIIVAIGSILFFISDFMLMLDLFGGISVASYLCLSTYYPAQFLLAMSLFIYACVNSSKQEKNNSMSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7G7</accession>
    <name>A0A174A7G7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnA_1</name>
        <name evidence="5" type="ORF">ERS852471_00567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263711.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84591">
        <property type="protein sequence ID" value="CUN84591"/>
        <property type="gene ID" value="ERS852471_00567"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="105"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="443" mass="50511" checksum="C5EF7B1FA2615916" modified="2016-09-07" version="1">MSKYTREDILRLVEENDIKFIRLQFTDIFGFLKNVAITDRQLEKALDNNIMFDGSSISGFVRIEESDMYLRPDLDTFSILPWRPQHGRVARLICDVYTPEGHAFEGDPRNILKKVLKEAEDMGYSFNVGPECEFFLLETDEKGRPKLETQDKSGYFDLSPLEGAENARRDMCMMLEDMGFEIEASHHEVAYGQNEIDFKYADALTTADSIMTFKLVVKSVAQRHGVYATFMPKPFFGINGSGMHVNMSLMKDGKNAFYDESDKLALSKDAYSFIAGLMKHVKELTAITNPLVNSYKRLVPDYEAPVYIAWSAKNRSPLIRVPATRGAGTRIELRCPDPSANPYLALACLLAAGLDGIKNNLTPPASIEKNIFGMSVEERKKEGIESLPGSLEESIKYMEESELIRKTLGDHTFYNYIKAKKIEWDEYRTKVTPWEIDNYLEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A8U9</accession>
    <name>A0A174A8U9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore coat protein CotH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cotH</name>
        <name evidence="3" type="ORF">ERS852471_00559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83905">
        <property type="protein sequence ID" value="CUN83905"/>
        <property type="gene ID" value="ERS852471_00559"/>
    </dbReference>
    <dbReference type="OrthoDB" id="688261at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="657" mass="73358" checksum="9ECA2CE456D27B70" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJE0</accession>
    <name>A0A174AJE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof family hydrolase</fullName>
            <ecNumber evidence="1">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263828.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88821">
        <property type="protein sequence ID" value="CUN88821"/>
        <property type="gene ID" value="ERS852471_00627"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="31410" checksum="1C8EB1778FDAC2B6" modified="2016-09-07" version="1">MGYKLIACDMDETLLNDNHEICQRNIDLIKKAREEYGVKFVPATGRGYELIQKELKTLELHNKEGEYVLSFNGGALTENIGNRILQFKGLSFSKMKELFEYGLKKDLCIHIYTQRDLYVFNISDSEEERLSRINHIRMDSNTVDFLENEEISKVIYQNVDVDYLMSLEEDMKSIIEGQCSVSYSSNRYMEFNTLGVDKGQGLIDLANLLNIDIKDTIAVGDNYNDMAMLKVAGLSVAAQNAVDDVKKTCDYVTKATNNEGVVAELIEKFILEKSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AUI5</accession>
    <name>A0A174AUI5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter ATPase</fullName>
            <ecNumber evidence="6">3.6.3.27</ecNumber>
            <ecNumber evidence="6">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phnC</name>
        <name evidence="6" type="ORF">ERS852471_00660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="6"/>
    <dbReference type="EC" id="3.6.3.28" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263880.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91075">
        <property type="protein sequence ID" value="CUN91075"/>
        <property type="gene ID" value="ERS852471_00660"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0918">Phosphonate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN91075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="28187" checksum="A48E1E9E1FF3DA48" modified="2016-09-07" version="1">MIKFDKVNKFYPNGLHALKNISLEINQGEFVAIIGLSGAGKSTLLRTINRMHDISEGSLTVNGQEVNDLKGKELRKFRRKVGMVFQSFNLVTRTTVINNVLTSRVPDMPLWKSIIGLYSKEDKVIALEALDKVGILDKSYVRADQLSGGQQQRVALARTLAQKPEIILADEPVAALDPITATQVMDDFKKINKELNMSVLINIHHVDLALKYADRVIGIKAGEIVYDGPAKDVDSEILKQIYGRELAEDEVMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1R2</accession>
    <name>A0A174B1R2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263954.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94333">
        <property type="protein sequence ID" value="CUN94333"/>
        <property type="gene ID" value="ERS852471_00689"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1375644at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="30216" checksum="62E8A164396F7949" modified="2016-09-07" version="1">MAIKSFKRYEKKILINKEQYDNLIPILLKYMDYDEYCKDGRKYSIYNLYYDTENDDVIRYSIYKPYYKEKLRLRSYRTPKTLEDKVFLELKKKINGIVNKRRVVMTLGAAYEFLESGKRPQTEDYINNQVLNEIEYYLKNNPVYPKVYIGYSRKALFGKEDRDFRVTFDSEIMARRDDLSLESGSYGNELLEDNMYLMEVKILGAMPLWFANILSELEIYNTHFSKYGDEYVKYTLERQNSDLRRREKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAT0</accession>
    <name>A0A174BAT0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF1_2</name>
        <name evidence="9" type="ORF">ERS852471_00754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264069.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98142">
        <property type="protein sequence ID" value="CUN98142"/>
        <property type="gene ID" value="ERS852471_00754"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="115"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="206"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN98142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="598" mass="69247" checksum="C2FD24EB5BADBEF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBU2</accession>
    <name>A0A174BBU2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264049.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97639">
        <property type="protein sequence ID" value="CUN97639"/>
        <property type="gene ID" value="ERS852471_00744"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="333"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="552"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN97639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="638" mass="73456" checksum="3CA439BDC547522C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BC59</accession>
    <name>A0A174BC59_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein ThiJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yajL</name>
        <name evidence="2" type="ORF">ERS852471_00761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98621">
        <property type="protein sequence ID" value="CUN98621"/>
        <property type="gene ID" value="ERS852471_00761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="178" mass="19401" checksum="B00E9132902E0B4F" modified="2016-09-07" version="1">MKVAVLLADGFETLEGLTVVDIMRRAGVCCHTFGTKSQNVRTSHDVVVEADKLLNDEVLEYDMIVLPGGMPGSVNLRDDEKVNEVVMDFYKNNKIVAAICAGPITLGKLKISEGKNVTCYPGFQDQLGNCNYKEELVVVDGNIITGRGPAAAIPFAFELLKHAAPDKVEELQKGMLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BCA3</accession>
    <name>A0A174BCA3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-containing protein</fullName>
            <ecNumber evidence="3">1.1.1.292</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">afr</name>
        <name evidence="3" type="ORF">ERS852471_00738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.292" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264038.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97346">
        <property type="protein sequence ID" value="CUN97346"/>
        <property type="gene ID" value="ERS852471_00738"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033712">
        <property type="term" value="F:1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN97346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="411" mass="46341" checksum="9E856EEEC3A6A14B" modified="2016-09-07" version="1">MKTVAIIGAGQRGQDIYANFIKNHSEMGKVVAVVEPNDFRRETLVREHNIPQENIFTNWDDFFKREKLADLAIISTLDRLHYEPTMKALDKGYNILLEKPMSINKEECVDMVKKAEDKGLLLMVCHVLRYTPFFTKLKEIIDSGEIGKVVNIQHNENVGAFHMAHSFVRGNWRNSDETSPIILQKSCHDMDILSWLVDDECESISSFGELSFFNNDNKPEGAADRCVSCKVEDCVFDARKIYPPMKGGWPSTVVSEVQTEEGILNAISENEYGRCVFNCDNNVCDHQSTIIKFKNGITATFSLSAFTDEISRTIKIMGTKGEIRGHEGKREIEVIKFRSNVKQDKDITIHKIEIPVGGHSGGDNGLMNELFRLLENKSVESLSSGSKSLQSHLMAFGAEEARKNNIVVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BMI4</accession>
    <name>A0A174BMI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferrichrome ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fhuC_1</name>
        <name evidence="5" type="ORF">ERS852471_00803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264168.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00786">
        <property type="protein sequence ID" value="CUO00786"/>
        <property type="gene ID" value="ERS852471_00803"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO00786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="29190" checksum="394694D8D8C03127" modified="2016-09-07" version="1">MIKVKNLEFSYEKDKKLIENLSVEIEKGKITTILGPNGSGKSTLLSIFTGLNKPTSGDVIINGKSIKKLKYKNIAREIATVHQQNTVPGDITVKELVSYGRIPHKKYFRGNNESDEDIVEWALEKTGLTNLKDKTVMSMSGGERQRAFIAMALAQKSKILFLDEPTTYLDIYHQIEILELVEELNREEELTVVMVLHDINQALKYSHNIIIMKNGKIINEGNAKKVITMDMLNKVYNIGGFINETNDETFFVPLKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRA2</accession>
    <name>A0A174BRA2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rubrerythrin</fullName>
            <ecNumber evidence="6">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbr3B_1</name>
        <name evidence="6" type="ORF">ERS852471_00848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264246.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03147">
        <property type="protein sequence ID" value="CUO03147"/>
        <property type="gene ID" value="ERS852471_00848"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01046">
        <property type="entry name" value="Rubrerythrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045236">
        <property type="entry name" value="Rubrerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO03147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="20077" checksum="8A17DAB8B5B654C1" modified="2016-09-07" version="1">MKKYICTVCGYVHEGDTPPEVCPICKAPASKFEEMKGDLQWADEHRVGIVEGIDPEIIEGLRANFMGECTEVGMYLAMGRVADREGYPEVAEAYKRIAYEEADHASKFAEILGEVVVADTKSNLSARVEAEFGACDGKKKLAALAKQNNLDAIHDTVHEMCKDEARHGRAFKGLLDRYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRR9</accession>
    <name>A0A174BRR9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tagatose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.2</ecNumber>
            <ecNumber evidence="4">4.1.2.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gatY</name>
        <name evidence="4" type="ORF">ERS852471_00833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.2" evidence="4"/>
    <dbReference type="EC" id="4.1.2.40" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264224.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02365">
        <property type="protein sequence ID" value="CUO02365"/>
        <property type="gene ID" value="ERS852471_00833"/>
    </dbReference>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050014">
        <property type="term" value="F:ketotetrose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009025">
        <property type="term" value="F:tagatose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO02365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="30627" checksum="755E35B5B38AE807" modified="2016-09-07" version="1">MELITTKQILKQAQEGNYAIGAFNVENMEMVMAVISAAEEMNAPVIMQTTPSTVKYAGLDYFLANAKVAASKAKVPVVMHLDHGSSFELAAQALRAGYTSIMIDGSHSDFESNIEISKAVVDMCKPSGVAVEAELGKVGGKEDDLDGGDGDLYTDPLEAKEFVERTGVDSLAIAIGTAHGMYKGEPKLDLERLSEIRKVVSVPLVLHGGSGIPDWKVQEAIKRGICKVNYATELRIAYTHGVNTYLKENPDTIDPKKYNKAGIDEVKKFVIEKIKVCGCQNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BXL7</accession>
    <name>A0A174BXL7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="1">3.1.3.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobC_2</name>
        <name evidence="1" type="ORF">ERS852471_00869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.73" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264284.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04256">
        <property type="protein sequence ID" value="CUO04256"/>
        <property type="gene ID" value="ERS852471_00869"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO04256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="23954" checksum="F7519C3017917CF7" modified="2016-09-07" version="1">MKTTVYLTRHGQTEWNLERRLQGRGNSPLTEAGIERAKELRDRIKDIHIDYIYSSPIERALDTANIIKGDKSIEVITDDGLMEMCFGDYEGRKTDEVMAENPEWNIDLIMHGDVKLCAPNGENLASVRARVAETMDRIIEENRGKSILIVTHGITLKALMYYFKDEEVNNEVMGQATLTKINVDENNEFDIEFKNDDSHFTVKGQKLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNP5</accession>
    <name>A0A174CNP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper-sensitive operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csoR_2</name>
        <name evidence="1" type="ORF">ERS852471_01026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264563.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15101">
        <property type="protein sequence ID" value="CUO15101"/>
        <property type="gene ID" value="ERS852471_01026"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10537" checksum="531AFA3F47B5A656" modified="2016-09-07" version="1">MNTHDHKHPNQKQIINRMSRIIGHTEAIKRMCIEEKDCTEILIQIAAVKSALNNVGKILLQDHINHCIIDAAKNDDEEAIEKLNTAIDRFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPM9</accession>
    <name>A0A174CPM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aadK_1</name>
        <name evidence="1" type="ORF">ERS852471_01023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO14957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264560.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14957">
        <property type="protein sequence ID" value="CUO14957"/>
        <property type="gene ID" value="ERS852471_01023"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1182556at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007530">
        <property type="entry name" value="Aminoglycoside_adenylylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04439">
        <property type="entry name" value="Adenyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000812">
        <property type="entry name" value="AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO14957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="34606" checksum="108F0089A715D394" modified="2016-09-07" version="1">MRNEKEMYELLLSVAEKDERIHAVYMNGSRTNKNVPRDIFQDYDIVYVVDETRGFIEDKNWIKNFGEILYMQYPDESPYYPSDKEKSYGWLMQFDDGNRIDLHVETIESARENILSDKLCKILLDKDNILPQIPEATDEDYYVKKPTEEEYIATCNEFWWCSNNIAKGLWRQEIPYVQDMANLIVRKELEKMLSWKVGIITDFSVSVGKSAKYMYKWLDKSDWESYLATYFGGNIEEAWDSVMRMCDLFKETAIFVGKELGYEYNSLEGRNARAFLEHVRQLPKDAIEINLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D432</accession>
    <name>A0A174D432_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264652.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20472">
        <property type="protein sequence ID" value="CUO20472"/>
        <property type="gene ID" value="ERS852471_01133"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1603415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046286">
        <property type="entry name" value="DUF6323"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19848">
        <property type="entry name" value="DUF6323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="18299" checksum="ADFFDC6737C33578" modified="2016-09-07" version="1">MNEKFSLVLQDMQKKQAIAEIKKCNELTIKYGLHLNDDEVKALVERRFDALKNTGRIEFSEGILTKIIEAFCDSPYIMQQNYEDTLLELQDAFYFFKSEAMDQISDDELIEFMKRHFDGKCQGSLEYLSGTTLEELCRNTRYGFKVDDTDIYGHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5A8</accession>
    <name>A0A174D5A8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20912">
        <property type="protein sequence ID" value="CUO20912"/>
        <property type="gene ID" value="ERS852471_01142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019723" evidence="1">
        <location>
            <begin position="30"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="44"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO20912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="247" mass="28074" checksum="3F036DE6D2483254" modified="2016-09-07" version="1">MNNLTRKYILKITLLAISLFFTASIFASASMDNPPDITEDSTKKIVYLTFDDGPSENTTKILDILKENDVKATFFIISPYIPSHNEIVKRIYDEGHSLGNHTADHEFNKIYTSEEAFMKSFNKQQEFIKSLTGSECRIFRFPGGSKNILVRNAHGKDFTKNIIIKLEQEGFHCYDWNVDSGDSHASSVPVGTICNNILKEMKDKEGNFKNPAIVLMHDCLTKKTTVQALPEIIKIFKDNGYEFDTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6H0</accession>
    <name>A0A174D6H0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rsgA</name>
        <name evidence="6" type="ORF">ERS852471_01150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21332">
        <property type="protein sequence ID" value="CUO21332"/>
        <property type="gene ID" value="ERS852471_01150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="104"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="112"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="203"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="359" mass="40686" checksum="22885BC5B7D5C021" modified="2016-09-07" version="1">MNKINLYNIGLTERFKQEATMYENLYLARVSVQHKDKYKVITEEGEVWAEVSGRFKYEALGTESFPAVGDWVMVDRLNDLTGNAIIHKVLRRKSAFERKVAGFRRDVQVVAANIDTVFICMALNNDFNIRRLERYISVAWDSMATPVIVLTKSDLCDDILEKQLEVESVAIGIEVIVTSSMSGEGYELIKRYIGRDKTVAFIGASGVGKSTLINKLMGEELLETGGISNYDKGRHTTTFRQLLILPDGGVVIDTPGMRELQLITADLDKSFADIDSLARDCKFSDCKHESEPGCAVRKAIENGELDEERLQSYKKINKELKYQELNSKSLEKEKINNMFGSISKMKKARREVKAKNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D752</accession>
    <name>A0A174D752_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nudix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264668.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21441">
        <property type="protein sequence ID" value="CUO21441"/>
        <property type="gene ID" value="ERS852471_01152"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="187" mass="21519" checksum="3C30B4415C6E790B" modified="2016-09-07" version="1">MSWIEDIKKYVPYNEQEAKDKELILGAISNFNNLLTRENVVMHITSSGYVINKNRDKVLMIYHKIYNSWAWTGGHADGDSDLLYVAIKEAKEETGIKNVVPVINDIFSLDVITVNGHIKRGSYVSSHLHLNVTYLLEADENEELVVNEEETEGVKWLPIDKLSDFCTEEYIINNIYNKLNKKIKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEF6</accession>
    <name>A0A174DEF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_3</name>
        <name evidence="5" type="ORF">ERS852471_01171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264685.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22306">
        <property type="protein sequence ID" value="CUO22306"/>
        <property type="gene ID" value="ERS852471_01171"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO22306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="295" mass="33081" checksum="600F555A1569AE3F" modified="2016-09-07" version="1">MYAIETKSLTKSYGKSRGIVDVNLKVKEGEIFGFVGPNGAGKSTTIRTLLNFIFPTSGEGKILGKDIVKKSSEIKKILGYVPSEVKFYDDIKVKDIIKYSSSFYNSCSKEEITRLCENLEVEVEKKMGELSLGNKKKVAIVQALIHNPKLLILDEPTNGLDPLIQKKLFEILLEQNKKGTTVFLSSHNLVEVENFCHRVAVIKEGRIIDTIEIDKLTKNLGLKVTIEAKGIKREDIESLGGEVISLKGTEFIFNYSNGADDLIKALSKFYIDKILIHEQSLEDTFMNYYENEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMQ9</accession>
    <name>A0A174DMQ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wcaJ_1</name>
        <name evidence="9" type="ORF">ERS852471_01212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25385">
        <property type="protein sequence ID" value="CUO25385"/>
        <property type="gene ID" value="ERS852471_01212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO25385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="24093" checksum="BAC80E0B7AB61478" modified="2016-09-07" version="1">MKKKRWNYDVIKRIIDITISGLALIILIPLFLVVAILIKVESPGKVIFSQDRVGKDGEIFRMYKFRSMVANAEELKRKLILENEATGPMFKIKNDPRITKIGRFLRRTSIDELPQLFNVLKGDMSLVGPRPSLPEEVEKFDPWMLRRLDVKPGLTCYWQVMGRNSISFEEWMKLDVKYVNERTLWIDIRLIFKTFFVLFGDTNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0D4</accession>
    <name>A0A174E0D4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter major facilitator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tetA_1</name>
        <name evidence="9" type="ORF">ERS852471_01297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264871.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29540">
        <property type="protein sequence ID" value="CUO29540"/>
        <property type="gene ID" value="ERS852471_01297"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="5"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO29540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="386" mass="42255" checksum="9AA6ECADA3B71516" modified="2016-09-07" version="1">MKKKSVTSLLILALLIQLVLNMAHPVTPVLIRSLGLPSIMFGIFFASMSLGNFFFSPIWGGLSDTKGRVKFLVLGLFGYGVSQLGFGFATNPILIVIFRILGGAFVTSYLTVSLAYLTDITTKDNRLKIMSYYAAVTTIGGSLGSLLGGILGNTNYKVTFVWQFILAVILSLALYLVLEETIQKKKIKANIKLNTFSFSKYKDLLNKNLLVVMILIMMFFFSSTSYNSSINYYIESILNLPPTFNGVFLSIAGMVGFLANIIITPIIGKKFTKEVSFKYITLILALSMMLVGLSKNLVIFFGAIILFVAVASVYVPVQQNIVSTLAKENYGTLMGLQNSAKAVGMVIGSLFAGAIFDFGEKLPFIASAIMLFIGFVILMKVKIEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ED44</accession>
    <name>A0A174ED44_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265081.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35764">
        <property type="protein sequence ID" value="CUO35764"/>
        <property type="gene ID" value="ERS852471_01416"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1913049at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO35764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="30521" checksum="985FBCFD6BAE0365" modified="2016-09-07" version="1">MNKKDFLQEKYEELNRLKISIQDYPKESIDNILKSISNICDEINKHLENKKHKEDKDIKNTKENNENDYNDECIDNNIEEKENDSNENRKRKKKSNEKHNIEREEIILTEQELSEFNGKDGKPPYIAIDGIIYDVSKINKWKNGQHHGMLAGQVLTEEYYKCHSKKLNLIKKARVVGKLKEENRGDRVFTKQELSKYNGKNGMPVYAAVNGVVYDFTKILQWQGGMHYGLMAGQDLTAYFEGCHSNNLDMLKNGTVVGTLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EI36</accession>
    <name>A0A174EI36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallopeptidase, family M24</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265077.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35630">
        <property type="protein sequence ID" value="CUO35630"/>
        <property type="gene ID" value="ERS852471_01414"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="139"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="358" mass="39937" checksum="EEA69E35BA06837E" modified="2016-09-07" version="1">MKDSRVKNVLVQMEKNNLSQILVTSPESIFYLTGKMIHPGERFLALYLDANGNHKFIVNKLFPIHEDLGVEIVWYDDIENPIDRLAKIVKAGEVLGVDKDLRATFLIDLMERNVVKTFTNSSPIIDMLRAIKDAEEIQIMKEASKINDAVMLKLWKNLKPGNSEKYYANLLSEIYEEEGASGFSFSPIIATSPNGADPHHGTGKDKIKVGDSVVLDIGGRYKNYCSDMTRTVFIGKEPSKEHAEIYNIVKNANEKAISIIKEGVKFSDIDKAARNLITDAGYGEYFTHRTGHSIGIEVHDFGNVSSVNHDEVKAGMIFSVEPGIYLKDNIGVRIEDLVLVTKDGCEVLNSVTKEITVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZI5</accession>
    <name>A0A174EZI5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.246</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mfpsA_1</name>
        <name evidence="3" type="ORF">ERS852471_01543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.246" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265316.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42697">
        <property type="protein sequence ID" value="CUO42697"/>
        <property type="gene ID" value="ERS852471_01543"/>
    </dbReference>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103011">
        <property type="term" value="F:mannosylfructose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="42670" checksum="F560F509FB665D1C" modified="2016-09-07" version="1">MQNLYINGTMLDERPTGLGVYIKNIVLELKKKNIKFKLFCPIEIEGVEVIKTTEKVKTSYKKKGGLYRFLWTQFLMPFKVNKNDIVYHPFQYLSLLTRAKQIITIHDFIPLYYPNVAKHQYYYYKFIMPLLLKKADKIICISENTKNDIIKFYNIDNNKIIRIYNGYDEELFNTKNIDENILEKYNLDKEYFISVGAGYSHKNIETALLAFKNILKDNNCDYVIVGKESEYIKKLKEKVEELGIHNNVKFVGYVADKDLPTLYNKAIAFIYPTLYEGFGLPILEAMACETLVLTSDNSSLPEVYGKSAIDFNALDVEGIEKAMRISINRRDIREEYIVLSKKQLEKFNWEKTAGDIIKVFNELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F224</accession>
    <name>A0A174F224_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB_1</name>
        <name evidence="7" type="ORF">ERS852471_01535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265300.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42340">
        <property type="protein sequence ID" value="CUO42340"/>
        <property type="gene ID" value="ERS852471_01535"/>
    </dbReference>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="5"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO42340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="350" mass="40513" checksum="01DA959B1817E3CD" modified="2016-09-07" version="1">MKTYLVTGGAGFIGSNFVLYMLKKYKDIKIVNLDKLTYAGNLENLKSIENDERHIFVQGDICDKELVTSLFERYEIDYVVNFAAESHVDRSIREPEVFAKTNVMGTVNMLNCAKNAWENVDGTWKEGVKFLHVSTDEVYGSLEETGYFMETTPLDPHSPYSSSKAGSDLMVKAYHDTYKMPMNITRCSNNYGPFQFPEKLIPLLINNCLQHKDLPVYGDGMNIRDWLFVEDHAKAIDMVINNGRDGEVYNVGGHNERTNITIVKTVIEYLNQNVDKDITDSLIKYVEDRKGHDRRYGIDPTKIKDELGWYPETTFEVGIKKTIKWYLDNQEWMENVTSGDYQKYYEKMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F561</accession>
    <name>A0A174F561_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF1659)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265422.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45383">
        <property type="protein sequence ID" value="CUO45383"/>
        <property type="gene ID" value="ERS852471_01597"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971409at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012454">
        <property type="entry name" value="DUF1659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07872">
        <property type="entry name" value="DUF1659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8031" checksum="D13E9EE1D553C3F5" modified="2016-09-07" version="1">MAANKELQKVSLAFKLENGIDDEGNTLYKTKSFANIKGSTSAEAIFAVAEGIKTVLRDDAVAYYLNETSIIQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8L6</accession>
    <name>A0A174F8L6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265445.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45917">
        <property type="protein sequence ID" value="CUO45917"/>
        <property type="gene ID" value="ERS852471_01609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8281" checksum="6050D697FB6E3AA4" modified="2016-09-07" version="1">MKRRTIMLGVIITMVCLTASISLIIAKGNGGRGLENLEIEYIVNESENMIESISDNDRYNLDSLLSFLDFIQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FC30</accession>
    <name>A0A174FC30_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GDP-mannose:glycolipid 4-beta-D-mannosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.251</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gumI</name>
        <name evidence="1" type="ORF">ERS852471_01615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.251" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265455.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46209">
        <property type="protein sequence ID" value="CUO46209"/>
        <property type="gene ID" value="ERS852471_01615"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="350" mass="40902" checksum="956AB51A3DFCB311" modified="2016-09-07" version="1">MKIALFPYSNKSNKYLELIKESIESLDIEINDMKTVLKNKSLFKDTEYFILNWYESLYTNSFPKQVLKNIYKHIELNKLKNKKIVWVIHNKIPHDDKHKFFSKNLMKYLAKISYKIVIHSSESIKVIEELSKDNSIKNKIVYVPHPNYIGAYKDENYDESIKCDDNINLFFVGAIKPYKNVDLLIQAYNELNLKNVTLSLAGKVSSLEYENYINNMIGGNPNIKTDFRFIDDNEINMLINKSDVLVLPYDINSSLNSGTILLAFSNKRTVISPLIGTLKDFKEDELFFAYNYNTKEEHLTKLKDMITKVVEVKKDDNMKLRVMGERCYDIIKENNSLGTIADIYKNEIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FF66</accession>
    <name>A0A174FF66_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">minC</name>
        <name evidence="6" type="ORF">ERS852471_01651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265524.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48922">
        <property type="protein sequence ID" value="CUO48922"/>
        <property type="gene ID" value="ERS852471_01651"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1665744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01222">
        <property type="entry name" value="minC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <feature type="domain" description="MinC_C" evidence="5">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="23484" checksum="F12B51131E3FB192" modified="2016-09-07" version="1">MKDSRIQVRGNKEGINAIIDIEKFATFDEVIEALVNTLSIGKGFYRNSIVKLTANFKHVTESEIAKLKDELFDKICIRDCVFEDISIKKGEDNKVFNGIYEGKTKFIKKTVRGGQLINYPGNIVIIGDINSGAEVVAGGNIIVLGSIKGQVRAGFSGNEKSIVAAFSLQPELLQISNIVTISPEDGIKPSYPEVAKIKDGAIVVEPYLPNKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFC2</accession>
    <name>A0A174FFC2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zeta toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001071501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47628">
        <property type="protein sequence ID" value="CUO47628"/>
        <property type="gene ID" value="ERS852471_01626"/>
    </dbReference>
    <dbReference type="GeneID" id="60291861"/>
    <dbReference type="GeneID" id="66773965"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="20225" checksum="B6A970D7D730832B" modified="2016-09-07" version="1">MNQGRIIVITGSPGTGKTTTASIVAKESDMDKSVHMHTDDFFHYLSKGAIPPHLPESNEQNLVVIEAFLEAAKRYARGGYDVIVDGIVGPWFLEPWKALAQEDYEVHYIVLRASKKETMKRAVERSKLDRKTNIELVETMWEQFSGLGVYESNVIDTTTFTIKDTVSAIKERVACGTSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FI78</accession>
    <name>A0A174FI78_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265556.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49873">
        <property type="protein sequence ID" value="CUO49873"/>
        <property type="gene ID" value="ERS852471_01669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="9185" checksum="34DEC78C5FAA629C" modified="2016-09-07" version="1">MDFMYIQLVIFLTIILSAVIAGKKGALISFLVWAVETYIIFKVDSFSYLQLITLGLSFQIAIIIAIIRDLVAKQFKKKVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FR61</accession>
    <name>A0A174FR61_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265659.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52693">
        <property type="protein sequence ID" value="CUO52693"/>
        <property type="gene ID" value="ERS852471_01730"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1441395at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021904" description="Peptidase_C39_2 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="144"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO52693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="36042" checksum="6FA973880105083A" modified="2016-09-07" version="1">MKKRFLQVLVATFILTSSTISMANASPSNSGFITNSFSKGDKSTYVDFESTKDKNKSDNAELYYEFKQGNISKDYYLQKSKNLSSDEYEKEFILSANTFLDESIERSNEQLSNAYLEKIKNTGNYTNVNLFSRAASGMIETLLQVPQEQDYYCGPSTAKSIISSRSSNPSQKTLAHKDWLETDVWGNTPWWVGGNADGYNPMQYTLNKYQGINYYSIYGSSVTASGLKSKVVYSIDRGYGIAADIWEVPGGSYLPGHPAGYEIFHWVPIDGYYNYGDTIHYAEPIYNASSVSWYQNIKNPYYNVSLSTMANVTDGRGIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRL8</accession>
    <name>A0A174FRL8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribose 5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265665.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52884">
        <property type="protein sequence ID" value="CUO52884"/>
        <property type="gene ID" value="ERS852471_01733"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2057308at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="96" mass="11656" checksum="1095B5ECE0B40455" modified="2016-09-07" version="1">MINIEKYRVVVDVLCKYYKITNFDLLYLLKNKECKYLFLLLLKEYGCLEKDKLIDELMFSSNKSINYNLKKAEERLLINKQFRDNYVILDKTIKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FU58</accession>
    <name>A0A174FU58_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hhoB</name>
        <name evidence="7" type="ORF">ERS852471_01752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265705.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53794">
        <property type="protein sequence ID" value="CUO53794"/>
        <property type="gene ID" value="ERS852471_01752"/>
    </dbReference>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="305"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO53794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="395" mass="42300" checksum="D4652EBCB75A5AEE" modified="2016-09-07" version="1">MDNENIYDAVYKEENLNQKNENNSYNSERIRKPRKKGGGMGKIIALVVSCSLLGGVAGSGLTYVMMNNEVDTTQQNTVSNVNTADVSFKNDSTLSITEAFEKVAPAVVTVSTKGVTSNGFFQQQYEGVGSGFIINEDGYILTNYHVIEGASEISVTLSDNTTVAAKVVNYDENQDVAMLKITDSDVKIPAVVELGDSDQLRQGESVIAIGTPLSTNLSQTVTNGIVSALNRNVETESGVMQNLIQTDASINPGNSGGPLVNTRGQVVGINTMKATGTDTEGIGFAIPINDISDKIESLSKPILNLGISIRTVDETLANKLSMEQGLYVVEVNEFSPAEKAGVKPGDLIVKVDGQRVKTFDELKEIKNSKNDGDTITLEVIRDGKTKTLDVTLTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G578</accession>
    <name>A0A174G578_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin A</fullName>
            <ecNumber evidence="3">2.1.1.226</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tlyA</name>
        <name evidence="3" type="ORF">ERS852471_01808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.226" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265814.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57634">
        <property type="protein sequence ID" value="CUO57634"/>
        <property type="gene ID" value="ERS852471_01808"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO57634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="30205" checksum="A7E58FE7903D2067" modified="2016-09-07" version="1">MSSKKERLDILLVEKGICNSRERAKTNIMAGLVFVDGQRVDKAGEKVNRDAEIIFKGEELKYVSRGGLKLEKAMNEFNISLDNKVCMDIGASTGGFTDCMLQNGAAKVFSVDVGYGQFAWKLRVDERVVCMERTNIRYVTPEDIGDKLDFASIDVSFISLRTIMPAVKNLLKDNGEVVALIKPQFEAGREKVGKKGVVRDKEVHKEVVSNIANYLIENDFNIIGMSFSPIKGPEGNREYLVYFSKDKEKESDFSLDKINDIIEESHSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6Q2</accession>
    <name>A0A174G6Q2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein SpoAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAB</name>
        <name evidence="2" type="ORF">ERS852471_01822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265840.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58172">
        <property type="protein sequence ID" value="CUO58172"/>
        <property type="gene ID" value="ERS852471_01822"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2031603at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014198">
        <property type="entry name" value="Spore_III_AB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09548">
        <property type="entry name" value="Spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021435">
        <property type="entry name" value="SpoIIIAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02833">
        <property type="entry name" value="spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="172" mass="19977" checksum="F35E3111BB36A194" modified="2016-09-07" version="1">MFRIIVILVVFLACIYIGFYFGEVFKHRSVELKDFQKALMLMNTEVLYSSTPLPTALLNISYKLESPFSKVFKETADMLEVGEIYSVYEGFNKSYNNHKDEFHLKADDFNIIKDFFFSLGESGVYGQEKIFNLTSEELKRKYLEAEEECKVNRKMYRGIGVCVGAIIAIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GE30</accession>
    <name>A0A174GE30_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretion pathway protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gspE</name>
        <name evidence="3" type="ORF">ERS852471_01834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58675">
        <property type="protein sequence ID" value="CUO58675"/>
        <property type="gene ID" value="ERS852471_01834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="53566" checksum="80BAE3C9BDA5C035" modified="2016-09-07" version="1">MLIDFEKINIKILRKITKDDAKRLKAIPYRNEGEKIYIIASNVNLNIKNELKFIFDKELEIKEIDENTLFGMIERLYVGLEDDVEEIIIRKSIELNASDIHFEPREKFTVVRMRIDGKLVITNILTLEEHLKIISKLKVKSNLDITEKRRPQDGKLTFKEMDKNYDLRLSFTNTIFGEKLVVRILYGQVFNYKLESLRLTKNQMKKIKEIIKVSNGLVLVNGPTGSGKSTTLYTILQEVNTEEVNITTLEDPVEVVMQGINQIALNKTIDLNFAEALRSTLRQDPDIIMVGEIRDDETAVISATAAITGHKVYSTIHTKTAREVFFRLEDMGVKNYIIKDSLVGIISQRLIRILCDDCKVLEGEIESEGKKINVYKKRGCSRCNFTGYRGRALVAAIHHMNKENKRKLVNLNEDDRLLSNKEMVDNLKELLKDGLISCNDYNLFLEVEEIEFDNEDKYTPKHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHG4</accession>
    <name>A0A174GHG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60319">
        <property type="protein sequence ID" value="CUO60319"/>
        <property type="gene ID" value="ERS852471_01871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6323" checksum="ED61AA3726FA007A" modified="2016-09-07" version="1">MHEEVLRLLNQYKETEALMNQYINLLDEKDYAQGKIDLIKTIIADLESLLTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPM6</accession>
    <name>A0A174GPM6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_01917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO62956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62956">
        <property type="protein sequence ID" value="CUO62956"/>
        <property type="gene ID" value="ERS852471_01917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="46"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="365"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO62956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="603" mass="66734" checksum="A9D2D6B410C9C859" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GT23</accession>
    <name>A0A174GT23_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266131.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65643">
        <property type="protein sequence ID" value="CUO65643"/>
        <property type="gene ID" value="ERS852471_01984"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915528at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="152" mass="17399" checksum="5FBBE31FC38B34C0" modified="2016-09-07" version="1">MNKVKILLKKCRTFINLDSKLKIEYGKAFIYTGCARAFILFVPFNKLRKRMGKVKEESPEEVDKNIYKEAVDVSEIVSIVSRHTPWESKCLVQALTAQKLLKEKEISTTLYLGVKKDRNNNMLAHAWLRCGEYYVTGGTNKDGYAVVAKFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H245</accession>
    <name>A0A174H245_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjjK</name>
        <name evidence="5" type="ORF">ERS852471_02038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266248.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68311">
        <property type="protein sequence ID" value="CUO68311"/>
        <property type="gene ID" value="ERS852471_02038"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="325"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="579" mass="66846" checksum="5D24219AAD53A06C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCC4</accession>
    <name>A0A174HCC4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_5</name>
        <name evidence="7" type="ORF">ERS852471_02132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266411.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72484">
        <property type="protein sequence ID" value="CUO72484"/>
        <property type="gene ID" value="ERS852471_02132"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO72484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="31431" checksum="EB453D154F432F6B" modified="2016-09-07" version="1">MKRKIIFLILVILSLFMCFPVIFLIAGSFMGKAELTGHLAPVLGKGKDFVSWGLLPKYPTIRSYVELLLDTPQFFVMFWNSVKIVFLSIAGQLIVGIAAAWGFARYNFRFKKILFTLYIVVMLMPFQVTMLSSYLVLDSFKLLDTHWSIILPAIFSTFSVFIMYRFFCNIPEAIIESARIDGASELKIFFKIGIPLGMPGIMSAVILQFLELWNLIEQPLTFLKDKSLWPLSIYLPNITLENADIAFTASAVTLIAAIIVFFAGQSYLEQGIAASAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHD9</accession>
    <name>A0A174HHD9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Formate acetyltransferase</fullName>
            <ecNumber evidence="5 14">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pflB</name>
        <name evidence="17" type="ORF">ERS852471_02128</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5 14"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266403.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72325">
        <property type="protein sequence ID" value="CUO72325"/>
        <property type="gene ID" value="ERS852471_02128"/>
    </dbReference>
    <dbReference type="OrthoDB" id="116406at2"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0556">Organic radical</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="16">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="15">
        <location>
            <begin position="620"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="13">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO72325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="743" mass="83372" checksum="80668BB4D219868E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIM9</accession>
    <name>A0A174HIM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferretin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266496.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74101">
        <property type="protein sequence ID" value="CUO74101"/>
        <property type="gene ID" value="ERS852471_02177"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1420351at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="34"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="19571" checksum="77B84B1473A9899B" modified="2016-09-07" version="1">MEYYVNIPYPPIEVKEKNPIYANLILLNYAGSVSELSAVTQYVYHEIAFSDNKYPDISETIKGISIVEMHHLQILGELIVKLGKDPGYWIYKHKKTNLWTPEFLSFNTDLKKALTIDIIDEKEAIAQYKRTAKQIDDTHIVDIIDRIILDEEYHIKLFTELYDKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJQ5</accession>
    <name>A0A174HJQ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75134">
        <property type="protein sequence ID" value="CUO75134"/>
        <property type="gene ID" value="ERS852471_02207"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971559at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="96" mass="11177" checksum="2DEE72DB7AAA2792" modified="2016-09-07" version="1">MSVALQIIQMIFYIVGILFMLSFMFIGIWSFIIFLKMYKNQRINNYLLDKINKSISSLNLSNDESVLDSLDFDFDDSFLDNNNLDSTNNVIKMDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HYH7</accession>
    <name>A0A174HYH7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dUTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266747.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79944">
        <property type="protein sequence ID" value="CUO79944"/>
        <property type="gene ID" value="ERS852471_02331"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1310739at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014871">
        <property type="entry name" value="dUTPase/dCTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08761">
        <property type="entry name" value="dUTPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO79944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="152" mass="17663" checksum="D7DB36E407FD7958" modified="2016-09-07" version="1">MNISSIVESQLEKNKQLLINHELPEYKLWVRKHLELHVKLGSIAEETKCYTYLENVSSSLNKDIIFKKYVDFLAHIISLGLYREYISDYEVQLKPNDYCLSDQFLNLYIDINDLIVSTSSDHFLTLLEDTLSLGVTLGYSEKDIINSFIYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2B9</accession>
    <name>A0A174I2B9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhnA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnA</name>
        <name evidence="4" type="ORF">ERS852471_02321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266729.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79498">
        <property type="protein sequence ID" value="CUO79498"/>
        <property type="gene ID" value="ERS852471_02321"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1507972at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO79498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="113" mass="12403" checksum="D878D9673360C560" modified="2016-09-07" version="1">MDNLPNCPKCNSEYTYEDGNLFICPECGHEWNTHSVSENNEDELVVKDANGNILKDGDSVTIIKDLKVKGASSALKAGTKVKNIRLVDGDHNIDCKIDGFGAMSLKSEFVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I860</accession>
    <name>A0A174I860_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bglK_4</name>
        <name evidence="1" type="ORF">ERS852471_02413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266882.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83382">
        <property type="protein sequence ID" value="CUO83382"/>
        <property type="gene ID" value="ERS852471_02413"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047700">
        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO83382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="297" mass="32779" checksum="35B73AE568FE38F5" modified="2016-09-07" version="1">MKKLAIDIGGTAIKYAIMDMDATIYERGELDTPTDTLEHLLDVISNLYYKFKDKVDGIALSMPGNIDSDTGEIYTPGALTYNANVNIVKAIQERVNVNIAVENDGKSAALAELWKGNLSSCKDGIVLIIGTGIGGGIIHQRKLIKGKHFFAGEVSYLMTDFNSQYMENVFALKGSTTALILQVAALKGIEPSALDGKKIFEWIHEGDNDSMVALENIANNIAVQIYNLQCLFDPEKVCIGGGISKQKLLIEKIQEKLDIIYEKIPFQIPHAIVENCAYYNDSNLIGALYNYKIHYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IA83</accession>
    <name>A0A174IA83_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">aat</name>
        <name evidence="5" type="ORF">ERS852471_02433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266918.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84074">
        <property type="protein sequence ID" value="CUO84074"/>
        <property type="gene ID" value="ERS852471_02433"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670846at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="25187" checksum="F38EF669A1D03D4C" modified="2016-09-07" version="1">MPVYRLSKEIIFPNPDLAEEDGLLAVGGDLKFERLILAYCNGIFPWYSDGEPILWWCPKPRFIIKPNEVNVSKSMKRVFNKGKFTVTFDKDFKAVIQNCKELRENKEGTWITDEMMDAYINLHKRGFASSVEVYNNERLVGGLYGVKIGKCFFGESMFSIESNASKVALISMCKKLEEEGFIFLDCQMHTNHLESMGGRFIDWEEFKLMLKEGIEFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IHJ1</accession>
    <name>A0A174IHJ1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta'</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaX1</name>
        <name evidence="6" type="ORF">ERS852471_02464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266976.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85676">
        <property type="protein sequence ID" value="CUO85676"/>
        <property type="gene ID" value="ERS852471_02464"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015199">
        <property type="entry name" value="DNA_pol_III_delta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09115">
        <property type="entry name" value="DNApol3-delta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNApol3-delta_C" evidence="5">
        <location>
            <begin position="210"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO85676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="35523" checksum="F6FA1EAE8A017C6D" modified="2016-09-07" version="1">MRKFIGYRDLVMNFNKRCSNGTLSHAHLICGEDGIGKSVLALNLAKLILKGDLDREYVDIINYKTEKASFGVDDVRAIIEEVQKKPFEGDKKVVIIHEGNKLTVQAQNALLKTIEEPPLGVYIIILCESLELVLDTIKSRCEIFKLTPLSKEELYEYAEIKGYDKNEPETKAAIAFSSGIPGRIDRYINDDKLKELRCKIVELLIKITKNDPEALLEEEEVLNSYKGDKEEVLSIMGDFIRDIMIHKEIENESLIINSDKIDQIKELTREMSFRKLNNLMSSIEEARRNIKNNVNWAVTIRVMLISFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IP35</accession>
    <name>A0A174IP35_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tufA</name>
        <name evidence="7" type="synonym">tuf</name>
        <name evidence="10" type="ORF">ERS852471_02491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86759">
        <property type="protein sequence ID" value="CUO86759"/>
        <property type="gene ID" value="ERS852471_02491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO86759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="409" mass="45024" checksum="885EC6C8C6DACCBA" modified="2016-09-07" version="1">MAKQKFERSKPHVNIGTIGHVDHGKTTLTAAITTVLANRGFAEAFNYADIDKAPEEKERGITINTAHVEYETEHRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLASRVGVDYIVVFLNKADMVDDEELLELVEMEVRELLSEYNFPGDDIPVIKGSALRALENPTDPEATACIMELMDAVDSYIPTPERATDKPFLMPVEDVFTITGRGTVATGRVERGVLHVSDEVEIVGLMEEKRKVVVTGIEMFRKLLDEAQAGDNIGALLRGVQRTDIERGQVLAKVGSVNPHSKFVGQVXXXXXXXXXXXXXVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGSIKLPDGMEMVMPGDHIDMNVELITQVAMDEGLRFAIREGGRTVGSGVVTSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IPJ4</accession>
    <name>A0A174IPJ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">ERS852471_02492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117023.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86800">
        <property type="protein sequence ID" value="CUO86800"/>
        <property type="gene ID" value="ERS852471_02492"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO86800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="102" mass="11538" checksum="B101F7B63114ACE0" modified="2016-09-07" version="1">MSKQKIRIRLKAFDHTILDQSAEKIVETAKTTGAKVVGPVPLPTEKDVITILRAVHKYKDSREQFEIRTHKRLIDIVNPSPKTVDALMRLNLPAGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IQ74</accession>
    <name>A0A174IQ74_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">chrA_2</name>
        <name evidence="8" type="ORF">ERS852471_02535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267087.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88601">
        <property type="protein sequence ID" value="CUO88601"/>
        <property type="gene ID" value="ERS852471_02535"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="177" mass="19245" checksum="8B65A141742EECEC" modified="2016-09-07" version="1">MKKSLELFLSIFKIGTFTFGGGYAMIPLIEEEVVVNKGWISKEEFLDILVVSQSLPGALAVNTSVFLGYKIGGFIGAMVALLAVILPSFLIILIIAVFFMKFRDNYYVNAAFKGITAAVPMLVLIGAISLSKGLEKNIRTLITIIVGIIALAFFNIHPVLVIIISGLYGVIFLKNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IT84</accession>
    <name>A0A174IT84_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">melR_5</name>
        <name evidence="3" type="ORF">ERS852471_02571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267156.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90563">
        <property type="protein sequence ID" value="CUO90563"/>
        <property type="gene ID" value="ERS852471_02571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO90563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="28462" checksum="9C0A0C3E25D7521E" modified="2016-09-07" version="1">MNALTLKFNMESFYFSTHLPIKAFSTEGQEYHSVGYDKTSDLSLKELDFNDLISRIYSDKKINSPIDISPIEDVNFTVCPIISKNYEHGFYLIGPYTTNDASSKAIFKPKHCIIYLLNILYIKLENIDDNTSSKTSYNFNVNKAIKYIEENYKKTITLDEVCSNININKSYFCTIFKEHTGKTFSHYLSHYRVDKSKELLKDTDLSITEVALTVGYNSVNYFNNNFKRLNNITPVQYRNEINNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IV33</accession>
    <name>A0A174IV33_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore-cortex-lytic enzyme, sleb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sleB</name>
        <name evidence="3" type="ORF">ERS852471_02538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267092.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88740">
        <property type="protein sequence ID" value="CUO88740"/>
        <property type="gene ID" value="ERS852471_02538"/>
    </dbReference>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024633" evidence="1">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_2" evidence="2">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO88740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="196" mass="22393" checksum="4BC2EBB38F3EE2AE" modified="2016-09-07" version="1">MKKLKQIFSFILTLSLSVLYSYPKFASENDINIINDSANILLTTRENNNLINNFIDISNDEYVEVFSQNDKMIYLTQNDIYLMSQIVYAESKGEPFEGKVAVASVILNRVLSPNFPDTIEEVVFQPNAFSCVINNEIQVSPTQECFDAVHEAINGHDPTREALFFYNPEIATCSWMQEVDKTNITPIGHHVFFSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IV36</accession>
    <name>A0A174IV36_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">ERS852471_02540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267096.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88815">
        <property type="protein sequence ID" value="CUO88815"/>
        <property type="gene ID" value="ERS852471_02540"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="87"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="31524" checksum="B92430631E3F37E9" modified="2016-09-07" version="1">MQEFFTVVTNSLANISIMSIVDILVVAFIFYKGYMLIKETRAEQLLKGIVFIVILIPISGLLKLTMLNFILNKTLTIGVLSVVIIFQPEIRRALEHLGRSAFEDVYGFEDSEKRNIYVKEIVTAVSNLAETKTGALIVIEQSTGLAEIISNGTVLDARISANLLENIFVVNTPLHDGATIIGKNKILAAGCVLPLTGNKDINKKLGTRHRAAIGLSEISDAIVIIVSEETGTISLAINGRLTRNYDKEKLRVVLLKIMEHREEKRVKTAGKKVKLWITGIINKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IZU5</accession>
    <name>A0A174IZU5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO92993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267253.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92993">
        <property type="protein sequence ID" value="CUO92993"/>
        <property type="gene ID" value="ERS852471_02624"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1265821at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="230"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO92993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="31707" checksum="B7EA89FE40B8B06E" modified="2016-09-07" version="1">MVKNEKVENLKKYGTIVAGAFLFCLGINLFIVPVGLYNGGVVGISQIIRTLVNDYLSLPANFDISGIINFLLNVPLLFLAYKSISRKFFTGTVVSIVFQTIFFSIIAIPNVPIIDDRLAACLIGGIITGTGIGITLKAGGSGGGIDILGVYFAKKYSDFSVGKLGIIINAFIYGGCAILFELPIAIYSIIYTAFFGLIVDRIHYQNINTTATIFTKKQNIEKSIMSEMGRGVTCWKGYGAYTGEDTLVLVTVISKYEINQLKKIVYDIDDKAFVIFNEGMNVTGNFEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J140</accession>
    <name>A0A174J140_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267235.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92371">
        <property type="protein sequence ID" value="CUO92371"/>
        <property type="gene ID" value="ERS852471_02619"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1987484at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO92371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="20770" checksum="AFDBAA3AE11C8946" modified="2016-09-07" version="1">MLLKITELVDENSKKLMDIYRESNIDNIKHFYPKITDMEIGRRKVEKDYVNYLKNDFLTDSDRCCYVWEENGIWVSALRFYKIKDKLYYLEALETHPDYRKKGFAEKLICGVIDKLKSDGDFEIKSYTGKKNIASQMTHEKCGFKRIEERVFNYSINEYVENVINYIYSYEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J1B8</accession>
    <name>A0A174J1B8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267239.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92441">
        <property type="protein sequence ID" value="CUO92441"/>
        <property type="gene ID" value="ERS852471_02621"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909525at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO92441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="50" mass="5876" checksum="BD3449CF132E1E7B" modified="2016-09-07" version="1">MTDKTLVCVDCGAEFVFTVGEQEFYKEKGFDNEPKRCLACRRAKKEQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J234</accession>
    <name>A0A174J234_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267291.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93842">
        <property type="protein sequence ID" value="CUO93842"/>
        <property type="gene ID" value="ERS852471_02649"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827519at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO93842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="110" mass="12680" checksum="6EC725B6B8FC3BA1" modified="2016-09-07" version="1">MSKYKVGDELIIVNDPNEERQKLKNMTKLVVDGEYAEISWGLRIVSVDYDKPYVTLTYRNIDGKLNKVFAECLDADNFDAEMVLEKALLKAFQNEIINISVSKNTFRVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JAU0</accession>
    <name>A0A174JAU0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation P family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267401.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96753">
        <property type="protein sequence ID" value="CUO96753"/>
        <property type="gene ID" value="ERS852471_02708"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1416338at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010897">
        <property type="entry name" value="Spore_II_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07454">
        <property type="entry name" value="SpoIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02867">
        <property type="entry name" value="spore_II_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="373" mass="41789" checksum="C12A1C2DFF306FB6" modified="2016-09-07" version="1">MERYYSNNFKFNRGGPINNLRARGKTKFSIGYIVMILIVIFLAFRAFNVINSYSERGALPYVQLLNFSMPVVETTVYDESVHYESKLTLKKVIAETLGLTKISTSSIIGNEISLFKNIGNPEVTSKSSIPFLSRYEVSENSIAKVTEEDLAQLNAVSEAFDPNLKAILEPLNIKVLIYHTHSHEGYAEIGSDARWNTDNEDINVIGVGDVLAKELEEGYGITVIHDKTIHDNNYTVCYDRSQETLQNYLNEYGDFDLIIDLHRDSVEDKNLVTANINGQDLARIMFVTSVNSSRLEANTALASSLAGITNNLFPGLMRNKDIFHYEIGGINGFNMSLSDNIVVWEVGANVNTSVEAKLSAKYMARVIAEYFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JB36</accession>
    <name>A0A174JB36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267315.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94395">
        <property type="protein sequence ID" value="CUO94395"/>
        <property type="gene ID" value="ERS852471_02661"/>
    </dbReference>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO94395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="303" mass="35120" checksum="96D8B4F2485CA77E" modified="2016-09-07" version="1">MLGYIFIVLIIIALFILIIYANKLCKIVIYPKKKSYEDGYENQIKKLNLEDFYNNLEKEHITLKSDYGYDIKGIFIPNSNSKKCIILCHGITVNTNYSVKYIKPFYNRGFSVFMYDHRNHGLSGGTYTSMGYFEKYDLKTCANFLFNKLGPDINLGVLGESMGAATVLQYCAIDNRVSFCIEDCGYSDVFELFKHRLKEDYKINFLPLLFIADIIMKVRYKWSFKSASPLTYIKNIDIPILFIHGDMDDYVPTYMVYDLFNSKTTGFKELYIAKNAKHAEALTSNPDKYDEIIGNFLKKIDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JHK4</accession>
    <name>A0A174JHK4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mro_2</name>
        <name evidence="11" type="ORF">ERS852471_02762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267498.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99214">
        <property type="protein sequence ID" value="CUO99214"/>
        <property type="gene ID" value="ERS852471_02762"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512477at2"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO99214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="39729" checksum="095797009BA63FA4" modified="2016-09-07" version="1">MEIFEKVLGVFNNKEIICYSMSNSKGVEVRVLNYGGIITDILMPDRNNKRENIVLKYKNWESYIENPSYLGSLIGRTGGRIFNAEVDLGDKKLVLNKNYNPNQGHGGNEGFNKKFYEVKYEALENEAYIELSRVSPDMEENYPGNLKVKVKYILTEDNELKIRYYAKSDKDTLVNMTNHSYFNLSGDGKESILNHNLYINSKSIVELNDVQAPTGLLMFIEGTEYDFTSSKKIGKGIDGNHPQLLQGKGYDIPWYIEGGEGPDLELYDEKSGRALEVYTDRKTIVVYTHNYPDDEILENGKSSQWRYGVAIEPQNPPIGVNSCFVEDSILKQDEEYISQTIYKFEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JJC0</accession>
    <name>A0A174JJC0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dnaG_2</name>
        <name evidence="12" type="synonym">dnaG</name>
        <name evidence="17" type="ORF">ERS852471_02738</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267460.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97957">
        <property type="protein sequence ID" value="CUO97957"/>
        <property type="gene ID" value="ERS852471_02738"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO97957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="593" mass="68318" checksum="663A16EC9CB06841" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JJL8</accession>
    <name>A0A174JJL8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="11">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pflA_2</name>
        <name evidence="13" type="ORF">ERS852471_02778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267524.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99922">
        <property type="protein sequence ID" value="CUO99922"/>
        <property type="gene ID" value="ERS852471_02778"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="15"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO99922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="233" mass="26445" checksum="1CF7FE45B1230ED4" modified="2016-09-07" version="1">MIKGKIHSIESMGLVDGPGIRVVVFMQGCALRCKYCHNPDTWSGEGELLMTPEELINKVSRFRSYFERSGGGITFSGGDPLRQPEFLIEALKLCKDKNIHTTLDTSGVGFGNYEEILKYVDLVLFDVKHLTKEGYKDLAGSDIDESLKFLEACKKCGTKLWIRQVVVPGITDSEEYIRNLGDFIRTLENVEKVELLPYHLLGISKYETMGIKYRLEGIPAMDKEKCKELYKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JK53</accession>
    <name>A0A174JK53_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">ERS852471_02728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267440.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97555">
        <property type="protein sequence ID" value="CUO97555"/>
        <property type="gene ID" value="ERS852471_02728"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO97555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="166" mass="19930" checksum="729C4411C57D90BA" modified="2016-09-07" version="1">MLYTDNRQNQIEVTEEFIRELEEVCIYALEKEEVKQKCQISLLFVNNEEIREINKETRNIDKATDVLSFPMLDYPKGKFFKDVYKDKKFDVMYMDGDELVLGDMVLSLERAMEQSIEYNHSFKREVCYLVVHSILHLLGYDHMEEDEKKIMRTREEEILNGLDIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JNQ8</accession>
    <name>A0A174JNQ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO98800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267482.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98800">
        <property type="protein sequence ID" value="CUO98800"/>
        <property type="gene ID" value="ERS852471_02752"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1959322at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO98800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="25025" checksum="AC9EFD3D1BD23E93" modified="2016-09-07" version="1">MSLFLGKIHYWLFNKIQWFEILEEDIIKVAKDEGIYTEEINDKINKKYGEKLHNKPLEDMIDTGNIHGWLQSKINSAEGRMAAWTSIIINNSKNGINKIEKVYIDQGIKAAKEIKESGKSYKNAEEIYNLMNDYVLDGMPCDRVNVIEESSEELVKWTKRICVHKDIWDAENIDVKYFYDFRGLWIKAFVSELNRDFEYLEVDNDTRVIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JTB0</accession>
    <name>A0A174JTB0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267641.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03013">
        <property type="protein sequence ID" value="CUP03013"/>
        <property type="gene ID" value="ERS852471_02838"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2082774at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP03013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="82" mass="9935" checksum="D363CD075F8E008D" modified="2016-09-07" version="1">MSKLFNNKNKLEFKKNRKFIGEDLIRYNEDKNNMEFYELMKSGYIEMANINLEISQLFESSPETLQYEFDSINEYEKWLCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JU36</accession>
    <name>A0A174JU36_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb_2</name>
        <name evidence="5" type="ORF">ERS852471_02844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267653.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03293">
        <property type="protein sequence ID" value="CUP03293"/>
        <property type="gene ID" value="ERS852471_02844"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP03293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="13746" checksum="14B7E172CB24D95B" modified="2016-09-07" version="1">MNKIVLVGKLIKDPELKTIEDGEKVFTRFIVAVERNFKAADGTRKADLIPVTIWGRKAEVICKYMRKGSYISLSGRLRTGSYEDKLGNKKYIAEVVAEDFKFVGNRRIDKNDEDMNIETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K4Q0</accession>
    <name>A0A174K4Q0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_15</name>
        <name evidence="6" type="ORF">ERS852471_02859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04199">
        <property type="protein sequence ID" value="CUP04199"/>
        <property type="gene ID" value="ERS852471_02859"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP04199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="450" mass="49055" checksum="50B6C3109171AB12" modified="2016-09-07" version="1">MSDKIDFSKGKLLPIILKFSIPAAISLLITAIYNIIDRIFVGNFVGNTALAALSICFPLSFMMIAFGLTCSAGGSTLFSLFRGNKEEDKMNLSFGNAFIMVIVFEAILTAILLIFPDIFLKVFGVTDTTYNMAKTYYTIVSLGCVFQGLTFVFCDFVRASGKPIMGMCVTAIGAITNIVLDAIFVAVLNWGIEGAAIATVIGQVISVLFGAYLLFCGKTLVKIKKDTFKLDFKLQKEIFRCGFAFWIAQMAMGFISLIYNGQLGKYGGDIAISVYAVISSIMTFVIMPASGISQGIQPILAYNYSSKNTLRVKETLNKASMLSVGVTSIIWVVVMFFPASIIRAFGGGEELMSIGIAALRWNFIITPILGYVMLCTTFFQSIGRPNPSIVISLLRQVVALVPFLYLLPKVIGINGIFMAQPISDIIALVICVVLIKREFSNIANDKYNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5R1</accession>
    <name>A0A174K5R1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ilvE_3</name>
        <name evidence="17" type="ORF">ERS852471_02892</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267741.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05397">
        <property type="protein sequence ID" value="CUP05397"/>
        <property type="gene ID" value="ERS852471_02892"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="340" mass="37766" checksum="B6AB2BE426CFFED4" modified="2016-09-07" version="1">MNKTVNIDWGNLGFNYIKTDYRYISYWKDGKWDDGNLIEDNMLTISEASTALHYGQQCFEGLKAYKTKSGKIQLFRPDENAKRMNNSLSKLLMPEIPVDKFIDACKQVVKANEHFIPPYGTGGTLYLRPFVIGVGDNIGVKPATEYIFVVFCLPVGNYFKGGMTPCNFMIADYDRAAPHGTGANKVGGNYAASLQPHKVAVDRGFADCIYLDPATRKNIDEVGAANFFGITINNEFVTPKSSSILPSITKYSLMHIAEHYLGMKVYERDVPIDNLDVFKEAGACGTAAVITPIGGIEYNGHLHVFYSETEVGPVIKELYRILCGIQFGDIEGPEGWIFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7R8</accession>
    <name>A0A174K7R8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">potD_2</name>
        <name evidence="2" type="ORF">ERS852471_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267748.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05495">
        <property type="protein sequence ID" value="CUP05495"/>
        <property type="gene ID" value="ERS852471_02895"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025852" evidence="1">
        <location>
            <begin position="31"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="351" mass="39819" checksum="13D84CA184ED920A" modified="2016-09-07" version="1">MKKRKIKLLSICATAILSVGLFAGCGSSGSKQEINVLNYGANAAEGVFEEFEKETGIKVNETTFDDMQYMYQEVSSGKVNYDVILVSDDMAEKMIKEDMLQKINKDNIPNIVNMNEGDMGKPYDPNNDYTVPYMNGTIGLIYNTETVDEDITSWKSLFDPKYKDEIFMFDNIRDTIGVALKTLGYSLNSTDPAQLEEAKELLIKQKQEVNPIYGADEVLDLMRSGEKKIAMIWSGEGLNLEAEDGKFKYVIPVEGADYWLDSWAIPKDAKNVEGAEKFINFMCDKDIAFRTADEIGYTSPQKQAIDEQADEVKNNPNAYMPQEILDKCEGYKYLNQDELKLYQDVWMEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9C7</accession>
    <name>A0A174K9C7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267866.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08582">
        <property type="protein sequence ID" value="CUP08582"/>
        <property type="gene ID" value="ERS852471_02963"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2230533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP08582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="75" mass="8850" checksum="4F7C5054B6B7ECFF" modified="2016-09-07" version="1">MYKIEIKELGENKVSLCETIKYLQYNELYNLVKPYLNIEHLSFSIRNDCPDGREWGFIYAGDTIVGEIKITKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KBR3</accession>
    <name>A0A174KBR3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrite and sulfite reductase 4Fe-4S region</fullName>
            <ecNumber evidence="2">1.8.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dsvA</name>
        <name evidence="2" type="ORF">ERS852471_02956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.99.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08281">
        <property type="protein sequence ID" value="CUP08281"/>
        <property type="gene ID" value="ERS852471_02956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018551">
        <property type="term" value="F:hydrogensulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP08281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="35461" checksum="BAF28D635A651E42" modified="2016-09-07" version="1">MAEMTMTKLKVTPEDEKRVKAMGFLRNKGTDCFSGRIITVNGKITAAQNKCLSEATDLYGNGVVTLTTRLTIECQGIHYDNIEKFQEYIAKEGLVTGGTGSKVRPVVSCKGTTCQYGLIDTFALSEEIHERFFNGYANVKLPHKFKIAVGGCPNNCVKPDLNDVGIIGQNIPNYDEDGCNGCKKCGVADVCPIKAATLQDGILEINKDECNNCGRCIGKCHFDCIEDGTTGYKIYIGGRWGKKIAHGIALDKVFTTKEEALDVVEKLILLYREQGQTGERLSQTIERIGFERIQEELLSDAIWDRKQEILDAQLHLVGGATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KIY3</accession>
    <name>A0A174KIY3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267959.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10751">
        <property type="protein sequence ID" value="CUP10751"/>
        <property type="gene ID" value="ERS852471_03008"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2068744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="110" mass="11767" checksum="D7ECFD03CB133C3E" modified="2016-09-07" version="1">MTIEEAIKTLLGAIMFPFIVRLVWDELVKIFGPLGGWISAGLIVGTMWILNHHLGLINQSGEVWIDMALAVASGVFIATALESRNIKKSLPVLLGCCIGGVLAGIVLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLG7</accession>
    <name>A0A174KLG7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIG2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267972.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10997">
        <property type="protein sequence ID" value="CUP10997"/>
        <property type="gene ID" value="ERS852471_03014"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984556at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16704" checksum="BDFB7F919D9C77B5" modified="2016-09-07" version="1">MLEPREQKKIFVYGSLRTGFYNYDKYLKGKIENAVLGKVKGKLYHMPHKGYPALLEGNNVVLGEVMTIKNFEEVMIPMDKMENYYGVNDSRNEYNRVVMDVELENGEKESCYVYYYAMNDKEVFEKNSVYVDHGDWASFMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KNG6</accession>
    <name>A0A174KNG6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppB_2</name>
        <name evidence="7" type="ORF">ERS852471_03040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268025.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12381">
        <property type="protein sequence ID" value="CUP12381"/>
        <property type="gene ID" value="ERS852471_03040"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="34543" checksum="BF06096B768837D9" modified="2016-09-07" version="1">MKKYLFKRICIAVLTLLAILLVLFLMLEFMPGSPFNDEKLTADQIAILNAKYGLDQPIYIRFFNYVKNMITGDFGVSYTIAKNTPISTLLKTRLPISLKIGGQAVLLGTIVGLILGITAALNHNKIWDTITTIISVLGVSLPSYVFALALSYSLGFKLKWFPLLYSTGTPFKSSILPTIALCMFTVATIARFTRTEMLEVIDSDYILLAESKGIKGAKLIIRHELRNALIPIITVLAPLVVGLMTGSLVIEKIFSIPGIGSLLVTAIQSNDYNVIMALAFIYSAMYIGIMLIVDILYGVIDPRIRLAKEDNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KSA8</accession>
    <name>A0A174KSA8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268063.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13306">
        <property type="protein sequence ID" value="CUP13306"/>
        <property type="gene ID" value="ERS852471_03061"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1781357at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026346" evidence="2">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="24249" checksum="A25F00A129E84981" modified="2016-09-07" version="1">MKKIIISLLVSTMFLTACSLKDSDGKSGQNNKGDKEITESSNDTNEEKDVTKNTEDNKDNNTTGNYDNDSDNNSSIESSNNTSGESQSPSDDSINKENISEKVKDYIINGQGDKPEAEKYKWSTRFLNEVNIATLYDDYIAAGGNSSDIEEFAKYITLNAPILSNWEALFKEDLKDTYGEDVVKLEHLEGDLYQVYVNKDGSEVPFVVVSARTGYFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KV42</accession>
    <name>A0A174KV42_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15913">
        <property type="protein sequence ID" value="CUP15913"/>
        <property type="gene ID" value="ERS852471_03111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP15913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="47" mass="5460" checksum="624EB331007D0E2E" modified="2016-09-07" version="1">MKKGPMKNVKRKLHKGKLKGNLLVEMADDFMDLISNAKLYKKLTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L702</accession>
    <name>A0A174L702_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_03161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004455690.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18611">
        <property type="protein sequence ID" value="CUP18611"/>
        <property type="gene ID" value="ERS852471_03161"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP18611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="408" mass="44744" checksum="03F9FE2DB557DCA0" modified="2016-09-07" version="1">MVNKLSAYKTYLLFSAITAMCFSLVATVMIVYHIEIVHLNPLQLILVGTTLELACFIFEIPTGIVADVYSRKLSIVIGGVLTGVGFILEGSISSFVFVLVAQIVWGLGSTFISGSLEAWIAEEEKNKDLDEIYIKGAQAGQIGAFIGIVLSTVIANFSVRLPIIVSGVLFIILALFLWLYMPENNFKPSAPGDLNTFKKMVYTFKSGLKFVKSKSIIMILLAVTLFYGLSSEGYDRLSNAHFLQDTTLPKLGNLSSVTWFGIFGILGMILSFIVMHFMAKNLKNEDNRKNGKLLLCINILYISSMLIFALTRNFSLMLIAYLATNTFRIINEPIFSAWLNGHIDDNSRATVLSINGQMNSLGQILGGPIIGIIATNISVSIGIVCTSLLVAPVLVLYIISMIMDKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L8F7</accession>
    <name>A0A174L8F7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">xpt</name>
        <name evidence="3" type="ORF">ERS852471_03200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP20894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268305.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20894">
        <property type="protein sequence ID" value="CUP20894"/>
        <property type="gene ID" value="ERS852471_03200"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP20894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="191" mass="21227" checksum="3D2DDD58A1A1944A" modified="2016-09-07" version="1">MENLRRKILKEGQALSENVLKVDSFLNHGVDPELMYEIGTHFKDYFMQKNITKIFTIESSGIAPTVMTALQMGIPMVTLKKQSSKILNGEVYQTLVHSFTKGSDYELTLSKKYISEDDNILIIDDFLANGEAALGAARLVEMAGAKVAGIGIVIEKSFQPGREMLNKKGYDVYSLARVAKLGKGIIEFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L983</accession>
    <name>A0A174L983_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Restriction endonuclease S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_03154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268224.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18325">
        <property type="protein sequence ID" value="CUP18325"/>
        <property type="gene ID" value="ERS852471_03154"/>
    </dbReference>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="244"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP18325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="428" mass="48259" checksum="10E8BB1C4B734331" modified="2016-09-07" version="1">MKFKDTELGKVPSGWIVKSVEELINEKIIDKPLDGNNGSIHPTQKDFVESGIPFVMASDIESGRINYNTCKYISDETARGLKKGFAKCGDVLITHKASIGRVALVKENEYPFIVLTPQVTYYRINDSSILNNKFLMYYFTWNNFTELFTAWAQGGSTRAYLGITAQQKLPIVIPSISEQNKISDILSSLDKKIELNNEMNKTLEEMAQALFKRWFVDFEFPNEEGKPYKSSGGEMIESEFGIIPKDWRILKLDEISDITMGVSPSSKSYNEDKIGIALLNGASDFVGKLIKSTKFTTEPKKICKKGDMVFGVRATIGNTVFTDKEYALGRGVAAVSSQEIISREFIYFNLNNSMDNLINSASGSVFLNLKKSDITDLKVYFNEEVVKKFHNIAKSLIDKIIENDIESELLKEKRDLLLPKLMNGEIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LBA2</accession>
    <name>A0A174LBA2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Respiratory-chain NADH dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rnfC_2</name>
        <name evidence="13" type="ORF">ERS852471_03182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268273.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19797">
        <property type="protein sequence ID" value="CUP19797"/>
        <property type="gene ID" value="ERS852471_03182"/>
    </dbReference>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017054">
        <property type="entry name" value="PduS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036408">
        <property type="entry name" value="PduS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_51K" evidence="10">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="11">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RnfC_N" evidence="12">
        <location>
            <begin position="368"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="48221" checksum="8C197F275F45AA12" modified="2016-09-07" version="1">MVLQELKDLLKESGIVGAGGAGFPTYAKLSYDVNTVILNGAECEPLFRVDQNLLATHTDEILTGLSLVVEAVGAKEGILAYKEHYHDADEAIERVIYKYPRLRKKLLKDGYPAGDEVVLVYETTGMVVPQGGIPINVGAMVMNVETALNVYNAVEKKEPVTYKYLTVGGAVNEPKTLRVPIGTKFGDLLKEAGGPSIDSYKLLVGGPMTGVIGNLNDTVTKTTKGIFVLPMDNPIIELREYRLKIALKRAMGVCSQCRMCTDLCPRNLLGHSIEPHKIMNSLAFGLDYNSEVFVNALACCECNLCSAYSCHQGLNPKAIIADLKGRLRANGVKLAKVDSKVKEEKEFRRVPVGRVVARLKLTQYNVDAPLNEMTLEPNILTIKARQSIGAPVTFNVNKGDKVTSGQVIGSIDEKSLGVFLHSPIDGIISEINKDYLVIRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LEH3</accession>
    <name>A0A174LEH3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268287.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20265">
        <property type="protein sequence ID" value="CUP20265"/>
        <property type="gene ID" value="ERS852471_03191"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077046at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP20265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="8264" checksum="D7BBD729C7C3BA3D" modified="2016-09-07" version="1">MAVASLVLGIVSIIFSFFGGINFFGGIIGIVGIILGVYGKKDESKKGMATAGLVCSIIGTVLCFIFYVACVACVGSLGAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LEL6</accession>
    <name>A0A174LEL6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular polysaccharide biosynthesis protein Cap1B</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ywqD_5</name>
        <name evidence="2" type="ORF">ERS852471_03197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20508">
        <property type="protein sequence ID" value="CUP20508"/>
        <property type="gene ID" value="ERS852471_03197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="97" mass="10815" checksum="EEFE4DA4AFFD2A76" modified="2016-09-07" version="1">MFVVEKKPKSIAAEAYRTLRTNIQYSSFDKEYRTIVITSSEPGEGKTVTAGNLALALAQGESKVLLLDCDMRKPSVHKNFRISNESGLTDLLLHRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDF4</accession>
    <name>A0A173XDF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_1</name>
        <name evidence="2" type="ORF">ERS852471_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49036">
        <property type="protein sequence ID" value="CUN49036"/>
        <property type="gene ID" value="ERS852471_00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="483" mass="52597" checksum="DEBAA23550DC8ACB" modified="2016-09-07" version="1">MNNNGEEVINSIEDRELLIDKVFSIKNVINNLQVIDEIPKTKTLVRKAIKVAWPSTVESFLVAMVSFIDTIMVSTLGSYAIAAVGLTTQPKFLCLTLFISLNIAVSSVVARRKGEGDRKRANNTLFQALIITVGLSIIISALAIIFAEPFLRFAGSQSDTHGFSVIYFRIIMGGLIFNVVSLVINAAQRGCGNTKIAMRTNLASNLVNVVFNYLLIGGKFGFPALGVAGAAIATVLGTMVAFFMSIYSISHSDGFLNIKSFKKNFNIDKNSLKSLFSVGSSSFVEQIFMRTGFLLYSLIIANLGTSAFAAHQIGMNIINISFSLGDGLAVAGVALIGQNLGKKRPDLAKIYGSICRRMGLIASIMISIIYAILGKDIFRLFTNDPDVLKYSANIMSLVIVIVIFQIAHAIYGGCLRGAGDTKYTAIVSLISITFIRPSVGWLLTYPLSMGLMGAWFGILTDQIVRFYLTSRRFKSGKWTEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWN0</accession>
    <name>A0A173XWN0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262877.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55257">
        <property type="protein sequence ID" value="CUN55257"/>
        <property type="gene ID" value="ERS852471_00125"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="42"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN55257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="32017" checksum="2672FC2A395C8BAD" modified="2016-09-07" version="1">MYENFGKIIVTVGLDIVILLVIYIFLIYGDKKDVEETEWLTSTKFAHRGLYSNDQVIPENSLEAFSNAIKNNYGIELDVAFTKDKKTVVFHDDNLLRMTGLNKKISDCTLEELQNLTLADTEYKIPTFSEVLSLVDGKVPLIIEIKSNSDRDGLCKAVENELKNYKGNFCIESFDPLILSRIKKNMPEVIRGQLSMKFPKENKSPKTLKIVLEYLLLNCKSRPHFIAYNWIDSDNLSLKILRKLGIITIAWTVNSEKALEVSSEKFDTIIFEHCEPMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XX27</accession>
    <name>A0A173XX27_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate uptake ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_1</name>
        <name evidence="7" type="ORF">ERS852471_00148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262918.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56491">
        <property type="protein sequence ID" value="CUN56491"/>
        <property type="gene ID" value="ERS852471_00148"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN56491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="31117" checksum="D16C0AFC1E004198" modified="2016-09-07" version="1">MKNKLNIKVALKYFILVAFAIITLFPFYWMIASSFKDSFEVIQTPPTMVPNKILWENYSTALSMAPFGRYFINTIIVTILSIISTVIIAILSAFAFSHLEFKGRDLIFSIFLASMMIPGEVLIVTNFKTISQLGLMDTYTALFVPYMANVLYIYMLREFFLKIPKQLYYAAKVDGSSDWKFLWRIVVPMAKPSIITICILVGINSWNAFLWPLLVTNKENMRLLATGLTAFQSDAGNQYELIMAASTIITMPIIAVYIFLHKKIMSGISIGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XYY5</accession>
    <name>A0A173XYY5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase, Snf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262893.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55668">
        <property type="protein sequence ID" value="CUN55668"/>
        <property type="gene ID" value="ERS852471_00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="598"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="869"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN55668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1034" mass="120609" checksum="814B55AAD9A4283D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2P6</accession>
    <name>A0A173Y2P6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262987.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58174">
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        <property type="gene ID" value="ERS852471_00183"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="rRNA_methylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276">
        <property type="entry name" value="PTHR35276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="180" mass="20743" checksum="C4B56F730E5C092C" modified="2016-09-07" version="1">MFTYTADFSSLTHYIIKNFVKEKSVAIDGTLGNGFDTDFLADNFKLVYAFDIQKIACETYKQKEKQNVLVINDSHHKFLEYIKENVNCIVYNLGFLPGGDKSITTCYNSSLESIKLGLDILESEGMMLITSYRGHDEGMSEYIYIKEYLDNLPKNRYAVMKHEIINRSNKSPVLFVIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6B5</accession>
    <name>A0A173Y6B5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YhiN family flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262990.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58268">
        <property type="protein sequence ID" value="CUN58268"/>
        <property type="gene ID" value="ERS852471_00185"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="404" mass="44716" checksum="D8267643551F02A9" modified="2016-09-07" version="1">MADVVVIGGGPAGIMAAISAAKNNNVTLLEGNDRIGKKLFITGKGRCNVTNAKDISEFFDYIPGNPYFLYSSLYTFTNEDTINFFESQGIKLKTERGGRIFPYSDKSSDIIKGLNNGLEEANVKVKLNSKVTNILMNKSKIVAVEINNSKKIYADNFIFATGGASYPLTGSTGECFKLLENIGHTIVKLKPSLVPIEIKEEFIKELAGLSLRNIGLVIKSNNKVLYKEQGEIKFTYYGISGPLTLSGSRYIKENENFKILIDFKPALDHQELDKRIQRDFKKYINNDFKNSLNDLLPQKTIPIIIELSNIDPNKKVNEITREERKRLVDLLKSFEITVKGLRPLSEAIVTAGGVSTNEIDPSTMKSKIIENLSFAGEVIDVDAFTGGYNVQIALSTGYIAGINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y965</accession>
    <name>A0A173Y965_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="8">S12 MTTase</shortName>
            <shortName evidence="8">S12 methylthiotransferase</shortName>
            <ecNumber evidence="8">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rimO</name>
        <name evidence="12" type="ORF">ERS852471_00208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263030.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59525">
        <property type="protein sequence ID" value="CUN59525"/>
        <property type="gene ID" value="ERS852471_00208"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="142"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="375"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="445" mass="51099" checksum="9CF6B72158A6333F" modified="2016-09-07" version="1">MEKYKVGMVSLGCDKNRVDSELILGTINKYYEITNNPKEADIIIVNTCGFIESAKQESIDTILEMASYKTNYKCKMLIATGCLTQRYGDELLEQMPEIDILMGVNDYMKLHKLILEFIKEQKQISSASYSDLSINEGERILTTNSHTAYVRIAEGCNNFCTYCIIPKIRGKFRSRTMESVIKEVESLASQGVKEIILIAQDLTNYGVDIYNGKMLHKLAKKVSEVDNIEWVRLLYCYPEEIYDELIEEIATNNKIVKYLDIPIQHISDKILKLMGRKTNKKDIINIIDKLRKRIPNITLRTSLIVGFPNENDDDFNELKQFLLDYRLENVGVFSYSQEEGTPAAIMNGQIDESTKEKRLKELMLTQRKIMLDLNKLKIGNIYDTIIDGSNGEFFIGRSYMMSPEIDNIILVRKTKKVKIGDIIKVKITDVQEYDLIGDVIDESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9M4</accession>
    <name>A0A173Y9M4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_00216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59947">
        <property type="protein sequence ID" value="CUN59947"/>
        <property type="gene ID" value="ERS852471_00216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="31053" checksum="C2619573CCA979C2" modified="2016-09-07" version="1">MNDEMIEMMKFYEFYKKMKALEKSEELTSNKEENLLKTEGANSSTIKNNNLEDVHSHNKTEGETKNTKKKNYRATRPLEIDEYEEIIKLCKSGFIYGDKKTGRRKKFRANPSLAFALALQATLGFRASDIVNLKVEDFNRSKFSIKEIKTGKWQNRELGENMYNKFLEYVVENKLDGGDYIYPNKVRNMQQQLKIITDYLGYKNIGTHSFRKLFAHTLYEESGHDIELVRHALNHSDIKTTMRYLGVSMKKLKEATTKIDFSYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNX1</accession>
    <name>A0A173YNX1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11 12">Uridine kinase</fullName>
            <ecNumber evidence="7 11 12">2.7.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytidine monophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uridine monophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">udk_1</name>
        <name evidence="11" type="synonym">udk</name>
        <name evidence="14" type="ORF">ERS852471_00279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + cytidine = ADP + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11 12">
            <text>ATP + uridine = ADP + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 11 12">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 11 12">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7 11 12"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263181.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65303">
        <property type="protein sequence ID" value="CUN65303"/>
        <property type="gene ID" value="ERS852471_00279"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00551">
        <property type="entry name" value="Uridine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026008">
        <property type="entry name" value="Uridine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="13">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN65303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="23547" checksum="A245654401439F44" modified="2016-09-07" version="1">MRRPVLIGITGGTGSGKSTIADALYSTFSEDCIAMIQQDMYYKDQSHLSMEERVKTNYDHPMAFDNDLLVEHLKSLINGDSIEKPSYDFTVHNRAKETTTIAPRDIILVEGILILEDERIRDLLDIKVYVDTDADIRILRRLVRDINERGRTVESVIDQYLTMVRPMHMQFTEPSKRYADIIVPEGGHNYVAIDLLMTKIKDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZ33</accession>
    <name>A0A173YZ33_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsP</name>
        <name evidence="4" type="ORF">ERS852471_00342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118140.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68769">
        <property type="protein sequence ID" value="CUN68769"/>
        <property type="gene ID" value="ERS852471_00342"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN68769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="9293" checksum="06C7CCB49BCA62A8" modified="2016-09-07" version="1">MAVKIRLRRMGAKKAPFYRVVVADSRSPRDGRFIEEIGYYNPITEPAEIKIDEEKATKWIKNGAQPTDVVKRLFDKAGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZT1</accession>
    <name>A0A173YZT1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsB</name>
        <name evidence="6" type="ORF">ERS852471_00354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263315.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69484">
        <property type="protein sequence ID" value="CUN69484"/>
        <property type="gene ID" value="ERS852471_00354"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="233" mass="26353" checksum="55D385914C1B4217" modified="2016-09-07" version="1">MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIYIIDLQKTVKKVEEAYNFIREVSAEGKDILFVGTKKQAQEAIQEEAIRSNMHYVNNRWLGGMLTNFKTIKTRIARLEKLQKMEEDGTFEVLPKKEVIKLKGEMEKLENNLGGIRNLDVNNIGAMFVVDPRKEKNAISEAKILGIPVVAIVDTNCDPEEVDYVIPGNDDAIRAVKLITAKLADGIIEARQGEQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z647</accession>
    <name>A0A173Z647_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proton glutamate symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltP_1</name>
        <name evidence="8" type="ORF">ERS852471_00384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263371.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71149">
        <property type="protein sequence ID" value="CUN71149"/>
        <property type="gene ID" value="ERS852471_00384"/>
    </dbReference>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN71149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="44488" checksum="B084C23D1D3751E9" modified="2016-09-07" version="1">MKNKIGLTAKIFIGMGLGLLLGLAIRALPSGFIKDTVFLNGILKVLGTGFISAIKMLVVPLVFASITCGVASLANIKSLGRIGGKTVVFYLFTTAVAISIAIGLGFLINPGVGLDMSSLVLQEPTIGESQSIADLIISIIPTNPIKAMVDGDMLQIISFSILFGATISILGEKAKPVKTFMLSLNEVCLKMVNIVMAIAPFGVFGLIANTFATTGFEAFGSLVKYMIVVLLALAVHAVVVYSGLLKAFTGLNIVPFVKRFAKVAAVTFSTASSGAALPVTKKAMDDSGVSNKVSSFTIPLGATINMDGTAIMQGAATVFIAQIYGIELGIGQIMAVIVTATLASIGTAAVPGVGLVMLSMVLRTVGLPVEGIGLIMGVDRILDMCRTTINVFGDCICTLIVSKSENEFDEEKYYSDDDIMIDEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z9T5</accession>
    <name>A0A173Z9T5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263411.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72430">
        <property type="protein sequence ID" value="CUN72430"/>
        <property type="gene ID" value="ERS852471_00409"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2186754at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN72430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="531" mass="62973" checksum="AD00811144315A12" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBN2</accession>
    <name>A0A173ZBN2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDGSH-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73832">
        <property type="protein sequence ID" value="CUN73832"/>
        <property type="gene ID" value="ERS852471_00438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orange" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="39543" checksum="60C8B5D6433C0998" modified="2016-09-07" version="1">MNNVTSVLAQAKALSEQEQQELITQLEEYLILGSQVAKITKEVKEMRFSKGRVCCHCNGTDVVRNGKRNGVQRYLCRNCKKSFSDLTNSATYRSKKTLDKWLKYAKCMLSGYSIRKSAEEVEINIATSFYWRHKILNCISEFLGVGSVDGVVEADEVFFAYSYKGTKPANMPRPSRKRGKQVKKRGISKEQVCVGTALDRQGNMIMELLCTGRVTANELERLYSNRIGEDSILCTDSHKSYIQFATDMQLEHKRIKRGRHKEDIYHINHINSLHSNLKRWMSRFNGVATKYLENYLKWHKWINTFSTEKDTIRIKNLIIHSNIAHSYTMVKEFKNRKPIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDA0</accession>
    <name>A0A173ZDA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xanP_2</name>
        <name evidence="8" type="ORF">ERS852471_00445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74204">
        <property type="protein sequence ID" value="CUN74204"/>
        <property type="gene ID" value="ERS852471_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN74204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="439" mass="46094" checksum="E3158BBE71386907" modified="2016-09-07" version="1">MKNGSVYELDGRVSLKKAVPLGIQHVLAMFLGNVSPLIIVCGLLNIDANTKSMLIQNSMFIAGVATLIQLYPIFKVGSGLPVVMGTSSGFIGTEKVIGATYGYAAIMGASLVGALLEIVLGFFIKPLRKLFPPIVTSLVVISIGLSLLPVGIKYFAGGAGAADFGAPKHLLVGTIVMLVIIIVQNYTKGFIKTSAILIGIIIGYIVAIFMGMIDFTQVKEAAWFSLPRPFVMGFEFRLDAIISMVIMYIATAVETIGDISAIAVGGLGREATDEELSGGVIADGVASFIAALFGVAPNTSFSQNVGLVAVTKVVNRFVIMTGALFLILAGFFPKLSAVLSVMPQSVLGGAAVIMFAMIFVSGLQSLFRENLNGRNGLIVALAIGIGVGLGNVPEALAGLPTWIGNIFAQNGIIMTFVIATILNLILPKDKEEEEVMINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKY9</accession>
    <name>A0A173ZKY9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
            <ecNumber evidence="2">2.3.1.183</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bar</name>
        <name evidence="2" type="ORF">ERS852471_00486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.183" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263547.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76319">
        <property type="protein sequence ID" value="CUN76319"/>
        <property type="gene ID" value="ERS852471_00486"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102971">
        <property type="term" value="F:phosphinothricin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="22374" checksum="2F71C7BA79BDAA03" modified="2016-09-07" version="1">MAVRLATINDSTEILKVYKQYIDTAITFEYELPNKEEFKERVKGIITLYPYLVYEEEGKIIAYAYANRYKERAAYQWGAELSIYIDANYTSKGIGKILCLKLIELLKIQGVRTIYGCVTLPNDKSEKLQISLGFKKIGIYHNAGYKCGKWRDVAWFEKSIAIYDENPKEFVPITKIPEYKILKILELDHFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZY38</accession>
    <name>A0A173ZY38_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Superfamily II DNA and RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cshA_1</name>
        <name evidence="10" type="ORF">ERS852471_00521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263632.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81201">
        <property type="protein sequence ID" value="CUN81201"/>
        <property type="gene ID" value="ERS852471_00521"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="382" mass="43109" checksum="0D12393F82F3F4F7" modified="2016-09-07" version="1">MIKTFNELDLNLNIIEGLKKQNITEPTLIQQLSIPKALENKDIIGEAHTGSGKTLAYLIPLFHKINTEKREMQAIILAPTHELVMQIESQIKLLNTNSETNVTSLTIMGESNIEKQIKKLKDIKPHIIVGSPGRILDLIRKKKITAHTIKTIVIDEADSLLRNNRTSVIKDIIKTTMRDRQLMFFSASISSEALKEAKSLVKEDVEIIKTETKTSLNPNIEHICILGDNRDRFENLRKLLVAEKPKRAIVFVNNNTEMDVLTSKLMHHKVNAIYISGKSSKEDRKKAIDSFKSGKCPVLVSSDLSARGLDIPDVTHIINLDFPGSSNEYLHRAGRTARGLGSGKAISLITTKEIKWINSYEKEFKIKFIPARLYMGKLERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4Y0</accession>
    <name>A0A174A4Y0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MutS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mutS_2</name>
        <name evidence="5" type="ORF">ERS852471_00540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82545">
        <property type="protein sequence ID" value="CUN82545"/>
        <property type="gene ID" value="ERS852471_00540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="334"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN82545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="525" mass="61126" checksum="B1BBBEF69AF162BB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6V5</accession>
    <name>A0A174A6V5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_2</name>
        <name evidence="2" type="ORF">ERS852471_00549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83246">
        <property type="protein sequence ID" value="CUN83246"/>
        <property type="gene ID" value="ERS852471_00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="450" mass="49510" checksum="4F29FB92EE2CDA04" modified="2016-09-07" version="1">MTERHRELLKKIIIIAIPIAIQNLINVGVSVTDTLMIGNISEIQLAGISQANQPYFIFTTLIFGLASGSMVLNAQYWGQRDTGAIKAIMGLMMRIGIIGGLLASAVVLIFPEQAVSIFTNEAEVINYGAQYLRIVGLSYVFSAFTGIYLMGLRSIQNVKISMYIYGLSFILNVFLNYTFIFGKFGMPRLECRGAAIATLISRIFESILVLIYMYKIEDKVRYRVRDVFCKTSKYWKSIATYSLPVLLSEINWGLGISMQAAIIGRLGSNVIAANSFINVFQQLSGVAMMGLGGAAGVVLGNLIGKGKKHEEEVISFSKFLVKISIILGIIVITMVLIIRPIAPSFINASEQTAELIKSMLYVSAFLLFFQAITITIFVGILRAGGDTAFCAAIDIATLWICKIGLGLLCAFVLKLHPVLVYLILSSDECVKALITIPRVWKGKWIHYTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9M2</accession>
    <name>A0A174A9M2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263723.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85017">
        <property type="protein sequence ID" value="CUN85017"/>
        <property type="gene ID" value="ERS852471_00573"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366413at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="88"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN85017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="684" mass="76605" checksum="57C1B81171220038" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AAB9</accession>
    <name>A0A174AAB9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase NADH/NADPH small subunit</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD_2</name>
        <name evidence="7" type="ORF">ERS852471_00564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263705.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84398">
        <property type="protein sequence ID" value="CUN84398"/>
        <property type="gene ID" value="ERS852471_00564"/>
    </dbReference>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="154"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="490" mass="54473" checksum="F417BFAC3614E298" modified="2016-09-07" version="1">MGRPDGFLVYERETGENIAPLDRINNYDEFHKSLSEDKQKEQGTRCMDCGIPYCQSGILINNRVSGCPLNNLIPEFNHLLYKGNYKLALQRLLMTNPFPEFTGRVCPAPCEHGCTVGLNGVSVSIKENERFIIDKAFSNGTMQAKPPICRTGKTIAIVGSGPAGLSAAYILNKLGHTVTVYEREDRVGGLLMYGIPNMKLDKSVVNRRVMLMKEEGVTFLTGVDVGKESKVTSMILNNYDSVILATGAPKPRDLNVKGRELRGIEFAVDYLKENTRTLLSPKIDNNNYIDAKNKNVLIIGGGDTGTDCVATALRQGAKSIIQLEITDKPPKARSDNNPWPQWANIFKEDYGQEEYVAKFGKDPRKYLTSVKELIGDENGNVKKAVITNVKWEKTEDNRVVPIPVENSEKLIGVDLVLIAMGFLGSEDYLAQALEIELNNRGNIKADDKSYKTNKDNIFVCGDARRGQSLVVWAIREGIDVAYNVHKYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIF6</accession>
    <name>A0A174AIF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murR_2</name>
        <name evidence="3" type="ORF">ERS852471_00621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263816.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88471">
        <property type="protein sequence ID" value="CUN88471"/>
        <property type="gene ID" value="ERS852471_00621"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="124"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="33350" checksum="FE309846CA439C81" modified="2016-09-07" version="1">MLIIERLEQCDFSASEKTLIDYILKAKESIKDKTTKEIAKETFTSASTLVRIAQKLGFSGWNELKESYLKELEYLNSHFDSIDANIPFNKNDSILSIANKIANLQKEAIQDTLSLITYKDLEKAIKIITNSSYINLFAVSNNALISQEFKHNMSRIGKRVEMCTLQGEQTFAAYLAEKSSCAMIISYSGETPSLKNVVSALKHKNIPIIAITSIGGNSLSEDADCVLRICTREKLYSKIATFTTSTSIEYVLNVIYSCIFSLNYDQNLNSRIKASHYIESGRYSTVDIIKEDFKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AV94</accession>
    <name>A0A174AV94_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor, putative, ChrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263888.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91335">
        <property type="protein sequence ID" value="CUN91335"/>
        <property type="gene ID" value="ERS852471_00664"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1977205at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN91335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="11912" checksum="9DA497693B0292A1" modified="2016-09-07" version="1">MKKLNLNRIEANREIVTENDRFKTVYFKFDEGKGLPNHKHNGFATIQVISGEVDMEFANGERIELKVGDFLPFDARIEHNVVAKEVSKVLVTIAKAPMIKNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDI8</accession>
    <name>A0A174BDI8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264099.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99062">
        <property type="protein sequence ID" value="CUN99062"/>
        <property type="gene ID" value="ERS852471_00770"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="25526" checksum="2CB655BD89400842" modified="2016-09-07" version="1">MEKVKLALFDIDYTITRKETLMEFYKYIVSKDIKNIKFLPRALYSGLMYGIKVYDEKKVKECFLKFIENIEEKDLAILTKKFYDERLSKILYKDALDMMHKLKSEGYMVILISASPEFYIKEFYAIDDVDFIIGTRFTFENGKFVRKMSGNNCKRDEKVSRLKAYLKENNIEADYENSYMFSDSLSDLPLLELVGKPYLINYNKNHNIEVLRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNY8</accession>
    <name>A0A174BNY8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264228.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02474">
        <property type="protein sequence ID" value="CUO02474"/>
        <property type="gene ID" value="ERS852471_00835"/>
    </dbReference>
    <dbReference type="OrthoDB" id="376209at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="PTHR11616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO02474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="504" mass="55622" checksum="03776CF549786F24" modified="2016-09-07" version="1">MDNSREQWGSKLGFILAAVGSAVGLGNIWRFPYVVYENGGGAFLVPYFVAIFTAGIPILILEYGMGHKFRGSTPLSIARANKKWEWLGWWPVVTAFFILSYYSMILSWAMKYFTLSFNKGWGSNTDAFFHNDFLQLTSSPFELGNIIWAVLIGIFLVWGIGWFICYKGVKGGIEKLNKVLLPILIGIMVIIVVRGVTLEGATLGLNKLFTPDWSRLTDPKVWISAYGQVFYSLSLAMGIMMTYSSYLPKKTDINNSAFMTAFANCGFEFLCAIGVFAILGFMATSQGVGIDEVVSSGVGLAFVVFPEVFTAMGSWGTILAVLFFACLVFAGLTSVVSLVEAIASSVIDKTNWERKKVVSGICILGVAMSAIFATGAGLYLLDIIDNFVNCYAIVGVGLLEAILIGWIIKPEVIRNHVNKISYFRIGKWWDFIVKFVTPMMLIIMLVQSLTAEFKNPYAGYPLAATLLYGWAVIGFGIILGLLISKKPWKNKDLNKVDEEEEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BTI3</accession>
    <name>A0A174BTI3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urocanate reductase</fullName>
            <ecNumber evidence="3">1.3.99.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fccA_3</name>
        <name evidence="5" type="ORF">ERS852471_00863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>A + dihydrourocanate = AH2 + urocanate</text>
            <dbReference type="Rhea" id="RHEA:36059"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27247"/>
            <dbReference type="ChEBI" id="CHEBI:72991"/>
            <dbReference type="EC" id="1.3.99.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.33" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264272.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03933">
        <property type="protein sequence ID" value="CUO03933"/>
        <property type="gene ID" value="ERS852471_00863"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="1 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022270505" description="Urocanate reductase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="526"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO03933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="601" mass="62429" checksum="E4A78DA73FDE90F6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C835</accession>
    <name>A0A174C835_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rnr</name>
        <name evidence="8" type="ORF">ERS852471_00914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264391.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08050">
        <property type="protein sequence ID" value="CUO08050"/>
        <property type="gene ID" value="ERS852471_00914"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="623"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO08050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="741" mass="85797" checksum="282FAB9BE00DD2E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8C0</accession>
    <name>A0A174C8C0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264387.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07946">
        <property type="protein sequence ID" value="CUO07946"/>
        <property type="gene ID" value="ERS852471_00912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO07946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="21887" checksum="17277B7CEB7210D8" modified="2016-09-07" version="1">MKKRKMNKFQKAVLDRVGIKKVSKIRRGLAVGVDWYLSSMFASIPILYIYSVVSGKAETPTSLALMKPGVGIVAGMMGIMIVSLYYIVIPLKKNKGQTLGKRLLGIKVVQDDGSDVNAKVLLKREILGVALIEGGIVASSKYFREILLVIGLSKVYEILVVLAMIIPFVSIVIMLFSKNSKMIHDFIGRTKVVEIAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CD59</accession>
    <name>A0A174CD59_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mro_1</name>
        <name evidence="11" type="ORF">ERS852471_00975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264503.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11104">
        <property type="protein sequence ID" value="CUO11104"/>
        <property type="gene ID" value="ERS852471_00975"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512477at2"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO11104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="346" mass="39440" checksum="420B9BFDBC6F6E25" modified="2016-09-07" version="1">MRITKREFGITKEGIAVHEFKIENQIGEYITILDYGCTLTSINVLDKNENLVDVCLGYKTLEEYENNISYLGAIIGRHANRIKEGKFILNDTKYELAINNGPNHLHGGKKGFDRYVWDHIINGNSITFFRVSKHLEEGYPGNLSIEVKYEFNDEGELIISYYATTDRETIVNLTNHCYFNLNGENKGNILGHKLKLNASKYTENDEHCLPTGNILNVEESPFDFREGKKIGRDINDEDIQLKNGLGYDHNFILDSEENMKYVGELEGDESGIEMKIYTTCPGVQFYSGNVLDGENGKSNTVYNKRAGLCLETQYFPNSLECSNFPSVILKEGESFKEKTIYKFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWJ7</accession>
    <name>A0A174CWJ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17397">
        <property type="protein sequence ID" value="CUO17397"/>
        <property type="gene ID" value="ERS852471_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="46" mass="5378" checksum="45867F5008BF07AB" modified="2016-09-07" version="1">METKELKDKKETVEIQAPQKIKYQCLHTEEAKECTCIRSKGLVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0R5</accession>
    <name>A0A174D0R5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Zinc transporter ZupT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">zupT_1</name>
        <name evidence="12" type="synonym">zupT</name>
        <name evidence="13" type="ORF">ERS852471_01071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates zinc uptake. May also transport other divalent cations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264602.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17446">
        <property type="protein sequence ID" value="CUO17446"/>
        <property type="gene ID" value="ERS852471_01071"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00548">
        <property type="entry name" value="ZupT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023498">
        <property type="entry name" value="Zn_transptr_ZupT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO17446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="28776" checksum="610836EBD1C7EB6F" modified="2016-09-07" version="1">MGVIFAFGLTLLAGLSTGIGSLIALLTKKTNNKFLAISLGFSGGVMIYVSLVEIYQDARISLVSFYGDTLGKWITVLAFFGGMLLIGIIDKIIPSPENPHEIKKVEDMDKNSESCNTSRSNLMRMGLFTAVALALHNFPEGIANFMSAMQDTTIAIPIAFAIAIHNIPEGIAVSVPIFYATGSRKKAFVYSFASGLTEPLGAIIGYTLLRPFMSEGVLGIVFSMVAGIMIFISLDELLPAAREYGEHHLSIYGMVAGMAVMAISLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D226</accession>
    <name>A0A174D226_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ecsA_1</name>
        <name evidence="6" type="ORF">ERS852471_01082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264607.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17896">
        <property type="protein sequence ID" value="CUO17896"/>
        <property type="gene ID" value="ERS852471_01082"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO17896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="304" mass="34368" checksum="D766519215D77E99" modified="2016-09-07" version="1">MKLEVKELRKTFEENEVLHGISFSVESGKALGLLGRNGAGKTTTIRILMDVFKANSGEILMDGRNFNPKDFQIGYLPEERGLYPKKKVMEQIVYLATLRGMTKKEAKESTRKWLNRLGVSEYENRKLETLSKGNQQKVQLAQTLVCNPDIVILDEPFSGLDPVNSQILKDVVNELIAENKLVIFSSHQMSYVEEFCDEIAIINKGEIVLSGNLKNIKKDFGKNRLILSANNMSLEELSNFAAENFADIVKVYETKKSFIVLELCDGKSKNDLLEKILTTDIDIEKFAEYEPTLTDIFVLKAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6Z3</accession>
    <name>A0A174D6Z3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264638.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19825">
        <property type="protein sequence ID" value="CUO19825"/>
        <property type="gene ID" value="ERS852471_01118"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="157" mass="18544" checksum="0CD46CCF7F301454" modified="2016-09-07" version="1">MVEFLRASEKDLDKLYKVIRNAFDEDKKNYGSGPEYYEDKNKLKYYLSNLTCYKAVIDNEIIGGMIIFNLGGGRYRLGAIFIDTEHQNKGIGTKAIEFLEETHKDAEVWELDTPYKNYRDQHFYEKLGYKKVAETVAEKNGFYLFIYEKIIRRSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D824</accession>
    <name>A0A174D824_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264676.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21902">
        <property type="protein sequence ID" value="CUO21902"/>
        <property type="gene ID" value="ERS852471_01162"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46169at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025832">
        <property type="entry name" value="GxGYxYP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038410">
        <property type="entry name" value="GxGYxYP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032626">
        <property type="entry name" value="GxGYxYP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14323">
        <property type="entry name" value="GxGYxYP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16216">
        <property type="entry name" value="GxGYxYP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GxGYxYP_N" evidence="2">
        <location>
            <begin position="113"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP_C" evidence="1">
        <location>
            <begin position="343"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="587" mass="67770" checksum="E2B0D003A93C6E86" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DHI4</accession>
    <name>A0A174DHI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264724.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25051">
        <property type="protein sequence ID" value="CUO25051"/>
        <property type="gene ID" value="ERS852471_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="409" mass="47132" checksum="C41EDAC95D16CD9D" modified="2016-09-07" version="1">MGIYVYINETRLFIITIWLVLLSPKLAEINGIFAYIPYALYILLIIKIFEKKFIAKEKIFINKYLGFTTLGLLLINAVSLIYNNYDTNIIFLTFTFLKKFSYIIFYIFFTNMNVEKKYININMKLILVYSLIQFPLIIFQFISNTNRDNISGLFGKSGTGILIQFFLYILVLIIVNKENFIKIKNFQFVFVSLLLMYSALAEVKIGFILIPLIYLMTIFLKKGSFRTILAILIIGLLISVSYKSFIKFYPDQNLFGSSEEFVDYAKNAYGVDSVNRFGFMNLLKSTVLTNKFKIYFGTGLGTTNPSNINVLAGAVAIEYDYLNLHFFTLPLNIVENGIIGTIIWISIYIYILAKNVYMYFKKRTDKSIINIMSIVITVIFIVYNSSIISSSIIILILWLILVVNNGIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DI09</accession>
    <name>A0A174DI09_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264728.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25232">
        <property type="protein sequence ID" value="CUO25232"/>
        <property type="gene ID" value="ERS852471_01209"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="196" mass="23505" checksum="81B5BF119A2D4ED2" modified="2016-09-07" version="1">MLIDNKIYKACKKFIKKHIHCAYKYSINLDNLNIDISYEFKLKNLNINHIDLIRNFYPSESDKTNHDLLLKRINDKSKDIFCVIDSFENICGIFSLSYTDTFIYEMNEIIRLNNEECYLFDDYTFIEHRRRGVQTFSVKARCDMARKSGYKKAFVIVDKDNEPSRKSMEKAGFKCEEKYYFMTVKNFRKLIIRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIB3</accession>
    <name>A0A174DIB3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaD_1</name>
        <name evidence="2" type="ORF">ERS852471_01211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.212" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264730.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25332">
        <property type="protein sequence ID" value="CUO25332"/>
        <property type="gene ID" value="ERS852471_01211"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="36363" checksum="C58C7E98CD1CFE38" modified="2016-09-07" version="1">MNIKVTVFTPTFNRGNVLYRVFESLCAQTFKDFEWVIIDDGSNDNTKELVNSYILQNNFPIVYRYQENSGKHIAMNRAVEIARGELFVIADSDDRFLPEALEILVNEWEKIAVNKRAEFKGVTCRCLDVYSNEPIGKKFIKDPLESNDLEIIFKYKCKYDMWGILNKSVLKEYPFPEIKGLRFFPEAIIWQRMARKYKTIYINKPLLYYYKDQSNATTASNNKRAKENIYLWKHYINDVFDYLRYDVILFLKSFIGLTRDGLLLSMSYKSIIGECNGVGRKFLCTIFIPAGTILYFMKNISYKNRSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLL0</accession>
    <name>A0A174DLL0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apeA</name>
        <name evidence="11" type="ORF">ERS852471_01231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264749.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26383">
        <property type="protein sequence ID" value="CUO26383"/>
        <property type="gene ID" value="ERS852471_01231"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO26383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="462" mass="51628" checksum="C0D0F078ED15B7C3" modified="2016-09-07" version="1">MSEEKTKNAWLKFDEKGRLDIFNFCEGYKNYMSVCKTERESVLEAIRLAEEKGYKDLNLVIKNGETLKSGDKVYLNNKDKALVLFLIGNEPIENGMRIIGSHVDSPRLDLKQHTLYEDGQMALMDTHYYGGIKKYQWIALPLAIHGVVVKKDGTKIDVVIGEDDNDPVVGISDLLVHLSGEQLQKKANEVIHGEDLNVLVGNIPLEGKENDAVKANILKLLKDKYDFEEEDFISAEIEVVPAGKARDLGLDRSMVMAYGQDDRICAYTSLMALLDLDKVEKTSVILLVDKEEVGSQGATGMHSRFFENAVAEIMDRLGQYSELKLRRALSNSAMLSADVTAAFDPNYASAYERKNTAYFGRGLVFSKYTGARGKSGCNDANPEFIAWLRNIMDKNNIAYQTAELGKVDQGGGGTIAYILAEYNMEVIDCGVALQNMHAPWEVSSKVDIYETMRGYKTFLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DU18</accession>
    <name>A0A174DU18_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264849.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28983">
        <property type="protein sequence ID" value="CUO28983"/>
        <property type="gene ID" value="ERS852471_01285"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2093432at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO28983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8911" checksum="18B053A2163D05E6" modified="2016-09-07" version="1">MEEFNLLEKFECHKKKIIENIDAAKDMELNKITAILVIDDDSEEVQRKLINWLIIEGYKVSLRREEYNILSIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DW91</accession>
    <name>A0A174DW91_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobD_1</name>
        <name evidence="10" type="synonym">cobD</name>
        <name evidence="11" type="ORF">ERS852471_01304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264883.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29862">
        <property type="protein sequence ID" value="CUO29862"/>
        <property type="gene ID" value="ERS852471_01304"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029688at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO29862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="36235" checksum="30BC8CF615C132AB" modified="2016-09-07" version="1">MIDFLLLNLISIGIAIVVDFIIGDPYGFPHPVIYMGKFISTLEKYFRKKAKDDKELKKYGVFIFLIVSFTTYLITFLIVNLFSFNKMLYILLNSFLLYTTVAAKCLKIESEKVYKALDDVDIKKARLMLSYIVGRDTTYLEEDEIVRAAVETVAENTSDGVIAPLFYGIIGGAPLAMMYKAINTMDSMLGYLTEKYKYIGYFPAKLDDIANFIPARITGMAMCISSPIVGGNIIRAFRIMIRDRKNHKSPNCAYPEGAAAGAMDIRLGGTNIYFGEVIEKPTIGDNIKPINRKHIKECNKLMIVSEILFFIFSICIVGVINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYL9</accession>
    <name>A0A174DYL9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ORF">ERS852471_01323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264915.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30651">
        <property type="protein sequence ID" value="CUO30651"/>
        <property type="gene ID" value="ERS852471_01323"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO30651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="32874" checksum="53E689D02521C43C" modified="2016-09-07" version="1">MSLFEGSGVALITPFKNNKVDYEKLSELIEFHIENKTDSIIICGTTGESSTMSDYEKKEIIKFTVDKVNKRIPVIAGTGGNNTSYAIQLSKYAEEVGVDGLLLVTPYYNKATQKGLIEHYNAIATEVNIPIILYNVPGRTGVNILPKTVYELSKIKNIKAIKEASGNISQVAEIARLCGDEFYIYSGNDDMIVPVLSLGGKGVISVVANILPKETHDIVMKYLEGKVLEARNAQLRMLDLINTLFIEVNPIPVKTAMNILGMEVGNLRLPLTDMEDKNKKILIQAMEEYGVRNWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZD4</accession>
    <name>A0A174DZD4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Accessory gene regulator B superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264929.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30972">
        <property type="protein sequence ID" value="CUO30972"/>
        <property type="gene ID" value="ERS852471_01330"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1320951at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006741">
        <property type="entry name" value="AgrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04647">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00793">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO30972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="24738" checksum="38E0EDA53B745AB2" modified="2016-09-07" version="1">MFSVDSIAEAITEIITKEVNLECEKKDVVKYGIFAFIQITLSLLCVVVFGAIFNVTIEALIVSFVTSILRKNSGGIHASEPGICLIIGTFATIIIALISKSININVDLIIFLGVIIFTYSYYLIYKLAPVDSVSKPIRKKEKRTRLKKNSIIILTIYLFISILNIIALKLGGNSEFAVYTMCIYLSIIWQIFSLTQIGHKILGEIDKRLMRVLYEGRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E1C0</accession>
    <name>A0A174E1C0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yusV_1</name>
        <name evidence="5" type="ORF">ERS852471_01309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264893.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30095">
        <property type="protein sequence ID" value="CUO30095"/>
        <property type="gene ID" value="ERS852471_01309"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO30095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29207" checksum="066DE3EB2A67C307" modified="2016-09-07" version="1">MKSLVHIDNIKFSYDEKEVLKGITLKFNKGKFYSIIGPNGCGKTTLIKNISSLLAPNKSTIFIDNKDLISMTPKEIAKILASVPQNIHINYEFKVYDVVMMGRVPHKGRFEGYNKKDREIVKKAMDKADIWKFKDKLVTELSGGELQRVVAARALAQDTDIILLDEPTSHLDLQYQIEFLKIFKDICNDKVIIAVLHDLNLVSLFSDEIIMLKDGEVIDIGEADKVMTRENIKKVYNIDVEIYNDNNRRYILPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E1K5</accession>
    <name>A0A174E1K5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yibN</name>
        <name evidence="2" type="ORF">ERS852471_01341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264949.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31347">
        <property type="protein sequence ID" value="CUO31347"/>
        <property type="gene ID" value="ERS852471_01341"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="102" mass="11642" checksum="CEF3671B8DB9B137" modified="2016-09-07" version="1">MIKSINNISALKLIDETKDLLILDVRRFSEFKSGKIPKSINIPVDELEYELEEIEEYKDKPILVYCKSGIRSSVACSLLEEEGFSHLYNLRGGILDYTGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E1T6</accession>
    <name>A0A174E1T6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aspartokinase</fullName>
            <ecNumber evidence="15">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">lysC2</name>
        <name evidence="18" type="ORF">ERS852471_01319</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="15"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264909.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30448">
        <property type="protein sequence ID" value="CUO30448"/>
        <property type="gene ID" value="ERS852471_01319"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="17">
        <location>
            <begin position="263"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="17">
        <location>
            <begin position="343"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO30448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="401" mass="44055" checksum="F973D4243464974D" modified="2016-09-07" version="1">MNIVVQKYGGTSVGSIEKIKFVARRVINEKEKGNEVVVVVSAMGKTTDNLINMSKEICNNPNKRELDMLLSTGEQMSISLLSMALEAEGYKSISLTGFQAGIKTQGIHTKNKIADIDVRKVKKYLQEGKIVVVAGFQGINEDGDITTLGRGGSDTTAVAIAAKLKCPCKIYTDVDGIYSIDPRVYKEAKKIDYISYEEMMEMASLGAGVMDARAVEIGCKYNVPIYVSLNTGDVKGTWIKEYDERMEERVITGLTISENNLMITINNVLFKSNNIATIFERLAQNFINIDMISQTAPANGYVNVSFTASKDDLETIKDVITKIKDEILGINISVELNITKVSVIGIGMMNQSGVTAKVFKIFAENNIEFKQVTTSEISISFAIDSKDKQKAANILAKELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBB2</accession>
    <name>A0A174EBB2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pth</name>
        <name evidence="4" type="ORF">ERS852471_01404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265057.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35084">
        <property type="protein sequence ID" value="CUO35084"/>
        <property type="gene ID" value="ERS852471_01404"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="21098" checksum="7FCDBD5D70496CEB" modified="2016-09-07" version="1">MFLIVGLGNPGKEYEGTRHNIGFEAVDYIADKYNIELNRIKFKGIFGEGMINGKKVILLKPTTYMNLSGESIREVVNFYKISNEEIIVIYDDISLEVGRLRIREKGSHGGHNGIKSIIANLSSDVFPRVKIGVGGPKGDLVSHVLGKFSNSEIEILRESIMATSEAVTTILSKGTKEAMNKFNGFKASAISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEN4</accession>
    <name>A0A174EEN4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ytgP</name>
        <name evidence="8" type="ORF">ERS852471_01400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265049.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34889">
        <property type="protein sequence ID" value="CUO34889"/>
        <property type="gene ID" value="ERS852471_01400"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="352"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="509" mass="55382" checksum="383D98923E4AF46E" modified="2016-09-07" version="1">MKKQSLIKGSIILGAAGIIAKFLGLFFRWPLILLIGDEGIGYYQLSYPLYMFFVAIASGVPVAMSKMISERNAVGDIEGTYEIVKESTYLMLVLGIGTSCVLFFFAKLIISFLKWDPKSYYALIGISFAPIAVSIMTIFRGFFQGLQNMTPSGVSQILEQVGRVIVGVGLAFVLLPRGIEFSAGGAAFGAAAGGTIASIYLYIKYRKVKKSMGIKKIRTNTDVLNKILKMAIPISIGATAGTIMNLIDAVLVPQKLIESGVADPTALYGQLTGKAAVLVNIPLTLSMALGTSLIPIIAENYVLRKKVELESKTNLAMKLAVVIAFPCTVGLFCLAGPVMKLLFFKAYDGYEILKYLSLSIPFIIITQTTTSILQGTNHYIRPVINLFIGCIVKVILTMFLVPIPQINIFGAVIASIASYVTVTILNIVALKTKIKTKLDVYDSIIKPLMSSLIMGIMVSITYIFSIGRTNNNSISCLLSIFVGIIIYIIAILVFRVFSISEIKNRVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EID7</accession>
    <name>A0A174EID7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265099.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36199">
        <property type="protein sequence ID" value="CUO36199"/>
        <property type="gene ID" value="ERS852471_01427"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="30412" checksum="DF145FC0A5C24612" modified="2016-09-07" version="1">MGNCSTCSSKASCNASKSAENNCGKISIKHGKIKNVIGVISGKGGVGKSTVSGILAVNLAKKGYKVGVLDADITGPSMPRFFGINEQRARMIAVDENNAIFEPVITKSGIKVMSMNLLIPKEDEPVIWRGPVVTGVLTQMFTDTNWGELDYLIIDMPPGTSDITLTIMQSFPIYELVVVSTPQDMVSMIVKKVVSMAEKMNIKIKGLIENMAYIVCTDCDKKLKVFSNKSSEEHAEYLGLPLLGELPINLELTEAVNEGRAEEYIKDNSLYSLIFEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EK98</accession>
    <name>A0A174EK98_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccpA_3</name>
        <name evidence="5" type="ORF">ERS852471_01446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265132.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36976">
        <property type="protein sequence ID" value="CUO36976"/>
        <property type="gene ID" value="ERS852471_01446"/>
    </dbReference>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO36976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="37111" checksum="2B8092488D2638CD" modified="2016-09-07" version="1">MATSIKDVAREAGVSIATVSRVLNDIDVVNEDTKKKVLDAIKKLGYRPNIVARSLKTQRTKTIGILVPDISSGFYPEIVRGAEDVANIYDYNVILCNSDFDYDKEKDYLRVLKEKMVDGVIYMSSSLQEESLDIINDLDLKTVLVETKDREGRLPSVTIDNIEASYEATKHLLEKGIKNIAFVGVKKEVANAWGDRFLGYEKALKEAGLEVDEDLVYLQNLKYKTGSDAAEKFLSLSKKFEGVVCASDEIAMGVINGLREKGINTPDDVSVIGFNNNAVASYFYPRLTTVNQPSYDMGSVAMRMLIKILNNKPLEEGQYVLDYKLIQRESCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EU30</accession>
    <name>A0A174EU30_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF1887)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265224.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39485">
        <property type="protein sequence ID" value="CUO39485"/>
        <property type="gene ID" value="ERS852471_01496"/>
    </dbReference>
    <dbReference type="OrthoDB" id="625921at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015093">
        <property type="entry name" value="DUF1887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09002">
        <property type="entry name" value="DUF1887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO39485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="376" mass="43391" checksum="03485EECB1D02DD9" modified="2016-09-07" version="1">MGLLINQLDEHNEGNILATTRYKVNEVIFIRQNNQVDLIDNIKNYYNKNFPTVKMNDVIIEEGEIDKLTDLVKRNRSDDLIINVTGGKRINSLALLELSIKSNIKAIYTDVKNKKIYTFNNGIDLTYEEFDDLDIKDIINAAGGELVEDSSELCNKKDLIYLSEQIYKHLDIWNKHKQKLYDTNIFKHIEEAPNKIEINIKLLTQEEKVLLNNILKKLEDMNELQYTEKNENIEVTFLNKYIKGFIFKSGTWLEIATNNLIKKIKEIDEARNGVVFLWSNENRTVRNEVDVVAVKDSVPIVISCKDSEKYNEMALNELNVYANKIGGKNAYKILVATREPCKGPVSIRAKEMGIHIVIFDGDENKFIKNIKAIIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYD0</accession>
    <name>A0A174EYD0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA_2</name>
        <name evidence="7" type="ORF">ERS852471_01538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265306.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42471">
        <property type="protein sequence ID" value="CUO42471"/>
        <property type="gene ID" value="ERS852471_01538"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="31930" checksum="9902FABEFF654008" modified="2016-09-07" version="1">MKGIVLAGGSGTRLYPVTKAMSKQMVPIYDKPMIYYPMSVLMLAGIKDILIISTPRDIVNFKELFKDGSEFGLNIEYAIQEAPNGLAEAFIIGEEFIGDDSVAMILGDNIFYGQSFSASLKEAAALEKGAQVFGYYVQDPRAFGVVGFDEEGKVTSLEEKPEHPKSKYAVPGLYFYDNSVVEKAKALRPSPRGELEITDLNKVYMEEGTLTVNLLGRGMAWLDTGTHESMLKASNFVEAVQTTQGMYIACLEEIAYRKGWISRDQVIELAKPLMKTGYGKYLMTIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQZ9</accession>
    <name>A0A174FQZ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22, glycoprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydiC</name>
        <name evidence="2" type="ORF">ERS852471_01683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265581.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50545">
        <property type="protein sequence ID" value="CUO50545"/>
        <property type="gene ID" value="ERS852471_01683"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="238" mass="26324" checksum="08FA0657D1E5C033" modified="2016-09-07" version="1">MIVLSMDSSSLVTTVALLRDEHVLGEFTINFKREHSVILMEKVEELLKDCEVDINDVDGFVVSKGPGSFTGLRIGMATVKGLSMGSNKPYVSISSLDALAYSLINFDGLICPIMDALRDSVFTCIYKNVDGKLTKVIDYSALSLEELATEINSKGEKVIFTGDGVYKHKDYLKENIPNAIFAPNHLNIIKASSLGELGMIELKNGNFDDKNSAPLYLKKPQAVRELEQRLAMKNENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTK6</accession>
    <name>A0A174FTK6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ORF">ERS852471_01732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265663.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52827">
        <property type="protein sequence ID" value="CUO52827"/>
        <property type="gene ID" value="ERS852471_01732"/>
    </dbReference>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="534" mass="60034" checksum="8F38225CF82A4262" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUK6</accession>
    <name>A0A174FUK6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gcp</name>
        <name evidence="6" type="synonym">tsaD</name>
        <name evidence="8" type="ORF">ERS852471_01754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265709.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53893">
        <property type="protein sequence ID" value="CUO53893"/>
        <property type="gene ID" value="ERS852471_01754"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO53893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="36050" checksum="8CF587AB4FFDAEAE" modified="2016-09-07" version="1">MEKKYILSIESSCDETSAAVVVDGREVLSNVIASQIDTHKKFGGVVPEVASRMHIEVISGVVEEALQKANVTLDQIDAIGVTYGPGLVGALLVGLQYAKGLAFATKKPLIGVNHIEGHICANYIQHKDLKPPFVSLVVSGGHTFIVHVKDYGQYEVIGQTRDDAAGEAYDKVARALGLGYPGGPKIDKLSKEGNPNAIEFPKAKFQEDTLDFSFSGVKSAVLNYLNKCKMQNIEVNAADVAASFQKAVVDVLTENVLLTCKRRKVNKIAIAGGVASNSTLRENLIKVAGKKGIDVLFPDMILCTDNAAMIGSAAYYNFINGKENNLSLNAKPNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2B3</accession>
    <name>A0A174G2B3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56121">
        <property type="protein sequence ID" value="CUO56121"/>
        <property type="gene ID" value="ERS852471_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIDA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA" evidence="1">
        <location>
            <begin position="258"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="333" mass="36300" checksum="8BF966F08B6803ED" modified="2016-09-07" version="1">MKVIIVGGGWAGCAAAITAKKAGAEVHIYEKTDLLLGLGNVGGIMRNNGRYTASEELIALGAGDLIKLTDKWAKHRNIDFPGHKHATLYDVNIIEGKVREYLLGMGIKLHLEKRVKDVDIEKNKINGILLSDDTYVSGDVFIETTGSTGPMGNCLRYGNGCSMCILRCPAFGPRLSISARCGVQDIQGERADDSLGAFSGSCKLAKESLSEDVRNELDQKGVVVLKVPEEDVNYDKLNKKVCQQYALKEFAENIVLLDTGHAKLMTTYYPLEKLRKIKGLEYAKYVDPYAGSKGNSIRYLSVAPRTNDMKVVGVDNLFCAGEKSGLFVGHTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G341</accession>
    <name>A0A174G341_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">mgsA</name>
        <name evidence="4" type="ORF">ERS852471_01795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265788.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56962">
        <property type="protein sequence ID" value="CUO56962"/>
        <property type="gene ID" value="ERS852471_01795"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726279at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO56962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="122" mass="13529" checksum="F747ADCE03B0EC21" modified="2016-09-07" version="1">MKVALIAHDKKKEEMIEFTKKNEDILKNMDLVATGTTGLRIMENTSLQVKRFKSGPLGGDQQIGALVSEHEVDMVIFLRDPLTAQPHEPDISALLRLCDVYKIPLATNIGTAELLLEATTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4Y0</accession>
    <name>A0A174G4Y0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nikB_2</name>
        <name evidence="7" type="ORF">ERS852471_01777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265754.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55940">
        <property type="protein sequence ID" value="CUO55940"/>
        <property type="gene ID" value="ERS852471_01777"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO55940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="329" mass="36550" checksum="B957BA309CB688D6" modified="2016-09-07" version="1">MRYILKRFSFYFMAFIGAFTLNFFLPRLMPGDPVQMRIGELARQGGKVDPSTIQAIEKMFGINSNEPLIITYFKNFVDILKGDWGVSFTNNLYPVTEVIKRPLGWTVFLCGTALIISFIINTALGIFVAWRRGSRLDTTVTVGGQIMANIPAIIIALTLSYTLAYSGIFPKGYAVTPLLYAKGFEYVKDVAYHAFLPVTAIIISSFGGIMGMRANMINQLGEDYIVMGVAKGVPDKKIMFKYCARNALLPVVTSFAMSVGFLLGGQLLVENIFNYPGLGKLMIQAINGRDYPLMQGILLMTTILMLTTNFIADISVFILDPRIRRQSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G951</accession>
    <name>A0A174G951_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage IV sporulation protein B</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
            <ecNumber evidence="3">3.4.21.116</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIVB</name>
        <name evidence="3" type="ORF">ERS852471_01804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EC" id="3.4.21.116" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265806.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57389">
        <property type="protein sequence ID" value="CUO57389"/>
        <property type="gene ID" value="ERS852471_01804"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1237700at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014219">
        <property type="entry name" value="Pept_S55_SpoIVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008763">
        <property type="entry name" value="Peptidase_S55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05580">
        <property type="entry name" value="Peptidase_S55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02860">
        <property type="entry name" value="spore_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51494">
        <property type="entry name" value="SPOIVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S55" evidence="2">
        <location>
            <begin position="165"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO57389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="396" mass="43315" checksum="CF0D0D3B7B57855C" modified="2016-09-07" version="1">MIKKFIKRFSIIAAPMFILTLITYLSISRIPDKIYINEESKLTDLSLHDTSFLNKIKLNNDKLNIDFLGLFPIKSVAVQTVPNLEVYPGGTSVGVKLSTNGVLVVGYSNVETLNGTEDSPGKSSGIELGDMILKVNGTDIESSKDLISKVKSSNSDFINVEILRGKSKLTKEIKLLKEGEEYKLGLWVRDSTAGIGTLTFYHEDSDTFGALGHPITDSDTNTVFSIKNGELLRSSILSVRKGQRGAPGELKGLFLNEKESIGSISRNMGSGIYGKTSEPLINPVFNEPMQVGYRNEINEGPAKIITTIGEDGPKLYDIEIVKLLPQDKPGAKSMIIKVTDEELLSRTGGIVQGMSGSPIIQNDKIIGAVTHVLINKPDYGYGIYIEWMLKDAEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9R7</accession>
    <name>A0A174G9R7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nusB</name>
        <name evidence="8" type="ORF">ERS852471_01814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265826.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57868">
        <property type="protein sequence ID" value="CUO57868"/>
        <property type="gene ID" value="ERS852471_01814"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO57868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="134" mass="15503" checksum="38731720B8FBE474" modified="2016-09-07" version="1">MKRQRSREIAMELLFGMELSKNSYEETIENFVEDYEMDLTTIDLEYIKSTVKVVTDNLEKIDGIITESLVNWKLDRISRVNLTILRLAVGEMLYVEDVPEKVAINEAIELTKKYSDEKSVSFINGVLDKAFKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHG6</accession>
    <name>A0A174GHG6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group 1 glycosyl transferase</fullName>
            <ecNumber evidence="3">2.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265916.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59915">
        <property type="protein sequence ID" value="CUO59915"/>
        <property type="gene ID" value="ERS852471_01862"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="385" mass="44062" checksum="B068726838C2B44B" modified="2016-09-07" version="1">MHIMFIPSWYANERNKVHGSFFKEQALALQSKGVKITVAYNEIWPLTLINKVKEKSGLYFNIEDNLRTYRYKNYNFIPKSPLMFKVFNKRMEKLFKEIEKKEGKIDIIHAQSSLWGGISAAYLSKKFNVPLVITEHSSVERGPYIRKSYIPCIVDSYNTAKELIAVGNGLKRELEELTKRDDIKVIGNLIHFSDFQLKDRKPNDKFIFFSLAFLEGEKGFDTLIKSFSKAFKDTNNCELVIGGDGSQREWLELLANKEGVSNKVTFLGALSRHDVSKWMKQADAFVLPSRYETFGVVYIEALASGTPVIGTFNGGAEDIITKDNGYIVNVDDINALANAMEKMAMNKDKFIPEKLREDCFNRFNPDVIADKIISVYKNIIKESEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKX9</accession>
    <name>A0A174GKX9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TIGR03905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265978.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61549">
        <property type="protein sequence ID" value="CUO61549"/>
        <property type="gene ID" value="ERS852471_01902"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023806">
        <property type="entry name" value="CHP03905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024434">
        <property type="entry name" value="TSCPD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12637">
        <property type="entry name" value="TSCPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03905">
        <property type="entry name" value="TIGR03905_4_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSCPD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="8635" checksum="363A3705C91CAB39" modified="2016-09-07" version="1">MYIYKTSGVCSTEIHIDVKDDKIENVNFVRGCAGNLLGISSLVKGMNVNDAIDKLQGIQCGSKGTSCPDQLAKALLSMKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GM41</accession>
    <name>A0A174GM41_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system, glucose-like IIB component</fullName>
            <ecNumber evidence="15">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ptsG_1</name>
        <name evidence="15" type="ORF">ERS852471_01919</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="15"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266012.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63031">
        <property type="protein sequence ID" value="CUO63031"/>
        <property type="gene ID" value="ERS852471_01919"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035550at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="480"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO63031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="558" mass="58961" checksum="CE2EC82567BE513B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSM9</accession>
    <name>A0A174GSM9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Signal peptidase I</fullName>
            <ecNumber evidence="4 7">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lepB</name>
        <name evidence="11" type="ORF">ERS852471_01929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266033.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63445">
        <property type="protein sequence ID" value="CUO63445"/>
        <property type="gene ID" value="ERS852471_01929"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="10">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="208" mass="23935" checksum="D11E7C13555C6E67" modified="2016-09-07" version="1">MDEFNNNNGYIHEEGKTSNVDNNIENSKLEKRSERNAKKNEKTGFFYDWVVPILIAVVLAVLINKFIVFKVKIPSESMVPTLNVGDRLFVTRVYNPENLDRGDVVVFHSDEKNEDMIKRLIGKPGDQIVIKDGIVTVNGETLYENYIGTPDKFNGTYEVPEGKYFFLGDNRFFSSDSRYWDNPYIDSSDIMGKAQLKVYPFDDFGMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3N9</accession>
    <name>A0A174H3N9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266293.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69463">
        <property type="protein sequence ID" value="CUO69463"/>
        <property type="gene ID" value="ERS852471_02068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="16839" checksum="C5911CD7F27842CE" modified="2016-09-07" version="1">MEKSDILKVNKLVFEYVLNLDDLQLKQLLDGVKVLTLKDGQVDKNNLVDKKKLVKEPRTNKEKAKDNKAEKSSESNILGEALIKLNSFLTKEEALDYLKNSGLKVKELKAIAKQAEIFVKSKSKKDEIIDKLVEGTVGVKIKMKILREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5J2</accession>
    <name>A0A174H5J2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68677">
        <property type="protein sequence ID" value="CUO68677"/>
        <property type="gene ID" value="ERS852471_02047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO68677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="96" mass="10803" checksum="4A16B838B8553C8E" modified="2016-09-07" version="1">MEGLLSRMFFSKSKGKDKAISTIENLSQGKVNREYVITNIKSNDEEMEKFLFSLGCYEGEIVTLVSILGDTYVIKIKDGRYSIDKQLATAISVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9S3</accession>
    <name>A0A174H9S3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF362)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70127">
        <property type="protein sequence ID" value="CUO70127"/>
        <property type="gene ID" value="ERS852471_02086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="42"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="303" mass="32833" checksum="8405355FD142D4EC" modified="2016-09-07" version="1">MRVRKNLNSTVAITQNSNESLAIKEGLNLLNISSMIKNDDVVVITPNFVNKGGVGYGDVVGPESLRELIKIVKSCNPKKVVVATASAEKDIESVMNDIGYTDVIKSENVEFINLNYGPFISVPLNHSGPTSTSLNKLYEEMTFLISFTQLKIHEEATMSASIKNIAMGWPSCEEHGYPKKNLGIHKDLHGFITAMLEKFTIDLSIVSANPAMIGTGPHNGIGNHTGIVLCGTDPVATDTIGARLLGFKPQAINYLYSSINKGLGCGEVTLESNSPIKILGMNLLDAEKHFNKCAYGKEFSVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD24</accession>
    <name>A0A174HD24_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sigma-54 factor interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tyrR</name>
        <name evidence="5" type="ORF">ERS852471_02141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266429.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72812">
        <property type="protein sequence ID" value="CUO72812"/>
        <property type="gene ID" value="ERS852471_02141"/>
    </dbReference>
    <dbReference type="OrthoDB" id="451517at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="81"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="441"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-4" evidence="3">
        <location>
            <begin position="549"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="800"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO72812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="904" mass="103129" checksum="74EA2310C6428540" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGP2</accession>
    <name>A0A174HGP2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266401.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72300">
        <property type="protein sequence ID" value="CUO72300"/>
        <property type="gene ID" value="ERS852471_02127"/>
    </dbReference>
    <dbReference type="OrthoDB" id="556766at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO72300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="312" mass="37451" checksum="E87C9C25CCF7F62E" modified="2016-09-07" version="1">MEKYHFSMILSEQHLFKAIPMYISLRQYCKSFKLFILCMNESVYAILNKIGFKDIILIPIKYLEDNNFELLKAKSNRSFHEYCWTLKPIFLYYIMNQYDKAKYYAHVDADLFFFSNIDNVFDENPNASIFLTHHRNSEEFKHYYELSGIYNTGFVGFRNNNEARVAVRLWGDRCLKKCTMEYDTVDKTFGDQRYVEDWVDIFKNVHVVNSIGANVAFWNIKNYKVSKRYNNVYINETPLIFYHFSSVVILGPREFDLCSFYHIDDENILVYIYDPYVRLLSNGIEGMKKEFPWFNIGFVDRRNIINLHNYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPN3</accession>
    <name>A0A174HPN3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266586.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76171">
        <property type="protein sequence ID" value="CUO76171"/>
        <property type="gene ID" value="ERS852471_02236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="186" mass="21099" checksum="19E228D3F9A088E5" modified="2016-09-07" version="1">MKYIITALIAILVILIFSFILTATINKGKSFKENLKITFMFSLVMLPIILLLPVSLFATFKASTVMLSLDVSNYQIFLLSIIGLFIIFICDFVSKQLITTIGTNMLSKKYSNEDLSEAQMMEIISKKQANIKIWNVVIIFLASLLLYMISMVVISIEFTGLFLVIISIINILNYQLFFRSSYKTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQ99</accession>
    <name>A0A174HQ99_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rph</name>
        <name evidence="7" type="ORF">ERS852471_02204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266524.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75045">
        <property type="protein sequence ID" value="CUO75045"/>
        <property type="gene ID" value="ERS852471_02204"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO75045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="27654" checksum="FAA2B9C0CA89F218" modified="2016-09-07" version="1">MRSDNRKNNNVRHTKITRNYIKHAEGSVLIEVGDTKVICTASIEDKVPPFLKGTGEGWITAEYNMLPRSTATRKVRDIARLKQDGRTMEIQRLIGRALRSVVDLKALGEKTIWIDCDVIQADGGTRTTSITGAFVALVDAINKLHRIKPFKVYPIREFVCATSVGIVNGEKMIDLCYEEDSSAQVDMNIVGTGSGEFVEIQGTGEEAPFSRKDLNELLDLGEKGIKQIIQIQKETLKMDALWIGTGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I271</accession>
    <name>A0A174I271_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266828.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81372">
        <property type="protein sequence ID" value="CUO81372"/>
        <property type="gene ID" value="ERS852471_02376"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2071059at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO81372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="68" mass="7539" checksum="3D9A63BBFE316371" modified="2016-09-07" version="1">MVEVKINTEFIKLDSFLKFCGAASLGSEAKMYILDELVSVNGEICTQRGKKLYVGDVVEFNGEAYKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I3L3</accession>
    <name>A0A174I3L3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MazG-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266776.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80516">
        <property type="protein sequence ID" value="CUO80516"/>
        <property type="gene ID" value="ERS852471_02353"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1869961at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="11945" checksum="9CEFC413FB5F1548" modified="2016-09-07" version="1">MRKEEFNIMANIKMIEELKANLLCLIGDLYTLLTRGTNIARDSILNCISGAILILYVLAQKLGYSCDEVDDDMSKKLKIGITEEHEYEREGKNLSKLQNHIKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IET6</accession>
    <name>A0A174IET6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266981.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85762">
        <property type="protein sequence ID" value="CUO85762"/>
        <property type="gene ID" value="ERS852471_02466"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2058866at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO85762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="68" mass="7618" checksum="3E9B9212D0760564" modified="2016-09-07" version="1">MKISIKINNLNKSTDVTTIRNILTNEEGIVACEISKAKKEVQIVYDNLTISSEDIINLIEMAGYMIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IEV0</accession>
    <name>A0A174IEV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, contains double-stranded beta-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266908.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83888">
        <property type="protein sequence ID" value="CUO83888"/>
        <property type="gene ID" value="ERS852471_02427"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="15366" checksum="4AAB98032E1071D0" modified="2016-09-07" version="1">MNKDSLKNINTIFPIGDELPEQISKYFIGTAYLNMLTTSGVGIGNVTFEPGCRNNWHIHHKGGQILLVISGRGWYQAEGEEPKELYPGDIVNIPAEVKHWHGAAKDSAFSHLAIEVPADGASNEWCEPVFDEEYLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IT86</accession>
    <name>A0A174IT86_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt transporter ATP-binding subunit</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ecfA1</name>
        <name evidence="8" type="ORF">ERS852471_02523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88120">
        <property type="protein sequence ID" value="CUO88120"/>
        <property type="gene ID" value="ERS852471_02523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04520">
        <property type="entry name" value="ECF_ATPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="30972" checksum="230291FD8CBE49F3" modified="2016-09-07" version="1">MTKMIECKNLVFKYDNFEDKAPKYAINGVNLEVEKGEFLVILGHNGSGKSTIAKHMNALLLPSEGTVVVNGLNTSEDNNLWEIRAAAGMVFQNPDNQLVATIVEEDVAFGPENLGVPPEEIRQRVDEALEKVGMLEYKKHAPHLLSGGQKQRIAIAGILAMKPKCIIFDEPTAMLDPSGRKEVLRNIKEVNKKYGITVVLITHYMDEAAEADRVIVMDGGKVILEGIPRDVFSQVKKMKDIGLDVPQVTELCYELQKAGIDIDTKILNVNEMVSALCQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ITE1</accession>
    <name>A0A174ITE1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89721">
        <property type="protein sequence ID" value="CUO89721"/>
        <property type="gene ID" value="ERS852471_02549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO89721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10303" checksum="CAAF7192DB2459BF" modified="2016-09-07" version="1">MPETTVKNPEEILDALVLVESSEEISEVNPEILVTSEDTNSNNESYNDETNKTLGKSFAIRNVSSNYIVILWSLLLVALVLIFKKIKFKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J410</accession>
    <name>A0A174J410_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Mn2+/Zn2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">znuB</name>
        <name evidence="8" type="ORF">ERS852471_02605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267213.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91819">
        <property type="protein sequence ID" value="CUO91819"/>
        <property type="gene ID" value="ERS852471_02605"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO91819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="30375" checksum="F867F63D0F7B8A60" modified="2016-09-07" version="1">MLESLYGFIDFILPFQWVHYDFMKNALIAVLLVTPLFGILGTMVVNNKMAFFADSLGHGAFTGIAIGILVGGISPTWGATIFSIFFAIAITLIKNKGNSSTDTIIGVFSSIAIALGLVLMSLGGNMNKFSSYLVGDLLSITPKEILMLVVLFIIILLVWSFIFNKLLLVSINSSLAKSRGTNTLLIELLFTITIAVVVTITVNWVGLLIINSLLVLPAAAARNVSKNIRQYHLISIIISLLSGIIGLILSYYLNTVTGATIVLISAIMFFITLGYKQKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J8A7</accession>
    <name>A0A174J8A7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpE</name>
        <name evidence="5" type="ORF">ERS852471_02672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267338.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94881">
        <property type="protein sequence ID" value="CUO94881"/>
        <property type="gene ID" value="ERS852471_02672"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1477438at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO94881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="22288" checksum="8C0F101CBE89CF34" modified="2016-09-07" version="1">MSDVKNITSKILKDAEVERDSILAASEDEKNKIISKRVNSAKALEDEILSKAEQEGKSKKDRIISSAKLKVRNDKLAQKQSVIDDVFDEALNKLCTLSADELSNFIRRSILSMDIEGDENLVLNHEGLKVIGLEFMDSLNAELKDKGLKGEIRLLKKEGSFRGGFILEKNGIEINNTYEALISSLRDELEFEVAKVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCF5</accession>
    <name>A0A174JCF5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug resistance protein 1</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">msbA</name>
        <name evidence="10" type="ORF">ERS852471_02698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267383.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96311">
        <property type="protein sequence ID" value="CUO96311"/>
        <property type="gene ID" value="ERS852471_02698"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="354"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO96311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="599" mass="66707" checksum="80353AC83557BECF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JIZ2</accession>
    <name>A0A174JIZ2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppdK</name>
        <name evidence="14" type="ORF">ERS852471_02735</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267454.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97837">
        <property type="protein sequence ID" value="CUO97837"/>
        <property type="gene ID" value="ERS852471_02735"/>
    </dbReference>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="423"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="519"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="768"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO97837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="876" mass="97462" checksum="4FFCB9CA1467FF2D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JL27</accession>
    <name>A0A174JL27_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98338">
        <property type="protein sequence ID" value="CUO98338"/>
        <property type="gene ID" value="ERS852471_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO98338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="306" mass="35964" checksum="D159AA4052ACA23A" modified="2016-09-07" version="1">MKYMKREKIFYQFYKAIEKCTAIGADKHSYKKSGCEKIKIFSYEDRRNIIKVTSLLCDYLEEFYPEIQYIKDINTEHVQSFFIEKANYCTKSTMKNYNYCIRKLEKMVRQELHLYVNYTSNVKIPNVNYTELRTIKMSDADLQIIINECDKSKSKAVSGIKVAIMFGLRVSEVCKLKGKDIRLNQGIIHVHDSKGKRCRDIKIETEEQRNLCEYIKSVVSDEDRICPLREDTVNVTIKRMLLKNKISRYKDAKTGIHSIRKAYATKEYEDNLRQCTDQTKAWNDTALKLGHNEGRTALKNAYVKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPF4</accession>
    <name>A0A174JPF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_02810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267589.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01674">
        <property type="protein sequence ID" value="CUP01674"/>
        <property type="gene ID" value="ERS852471_02810"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="116"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SPASM" evidence="6">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP01674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="468" mass="53885" checksum="6D521AEF405FED86" modified="2016-09-07" version="1">MISPKFKIQQLAIKQVLGYLRKDPEKNLPKVVSWLRKFDTENLYTAQYDMVDEYLKDPDNNWTRLMCNLVNNVDSHIVETVFTNFLLNASIKGWSVVAQSKEKYGYETPFTILVDPTTACNKKCIGCWAADYNKSLNLSYDELDKLFTDGKELGIYFYIMTGGEPLVRKNDILKLAKKHNDCVFMLFTNGTLIDQKFCEDLIEVGNLVPTISVEGFDDATDGRRGEGSWKDIMRAMDLMKSNRIPFGFSTCFTTANCDSVLSEEFIDLMIDKGAYFSWYFTFMPIGCKTDTSLMATPDQREKLYRTIRAWRNTKPIFNMDFWYDAEYVGGCVAGGRRYCHINANGDVEPCVFCHYSNANIKEVSLLEALGQPLFREYQKNQPFNNNQFRPCPILDNAPKIAEMVKNSGAKSTEFIDPEDVDDLCKKTINYGLTWAKRAEPLWKENVENKNKNMKVQEKEIEENDLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JVC4</accession>
    <name>A0A174JVC4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prsA_2</name>
        <name evidence="6" type="ORF">ERS852471_02855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267671.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03724">
        <property type="protein sequence ID" value="CUP03724"/>
        <property type="gene ID" value="ERS852471_02855"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="5">
        <location>
            <begin position="113"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP03724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="28339" checksum="9F2C9AA7E48519D8" modified="2016-09-07" version="1">MENKVLAIISGNEITENDLNNIIMRYPEDKRGYFSSDMGKKQLLEQMVQFELMNKLGLEMELDKTEEFKAQVKQVEKDLLTQAAVNKVLSEVTVTEEDAKKYYEDNKEMFKGKESVSAKHILVDNEDLCSEIKAKIDNNELTFEEAANEYSSCPSKEQGGNLGEFGRGMMVPEFENAAFELETGVVSQPVKTQFGYHLIKVESKNGADVMPFEAVKQEVLGRLTQQAQEKKFMTVIKELEDKYEVKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JX75</accession>
    <name>A0A174JX75_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">merR1</name>
        <name evidence="3" type="ORF">ERS852471_02809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267587.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01629">
        <property type="protein sequence ID" value="CUP01629"/>
        <property type="gene ID" value="ERS852471_02809"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP01629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="273" mass="32423" checksum="58D1D5A8C5812B31" modified="2016-09-07" version="1">MTIRKRYKIKEFSEEMGVTVDLVKHYEKYGIINPIKEQDCKYRFYTIQHGERILASKRFRNMGFTIRDSAKIMNEYSLEEIQATLDNKAKDIEKEIIKLNSMNKRIIELKEQCELFKKCEDKITIVISPGFYFLKQTENAEFDQDEITKERIKEWIEYFPFVTKALKVPKDYFTNEKSINYQWGLVIGEDTANNIGINCTYPVEYIKPQKCYRYVVAKPYNGSSIEALEEVINEVKRKKLKVVGDMFLEAGIDSFNKKINCREVHYIFWIPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KB98</accession>
    <name>A0A174KB98_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bglK_5</name>
        <name evidence="1" type="ORF">ERS852471_02922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP06845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267795.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06845">
        <property type="protein sequence ID" value="CUP06845"/>
        <property type="gene ID" value="ERS852471_02922"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047700">
        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP06845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="297" mass="32533" checksum="823067A6DBF1B7E3" modified="2016-09-07" version="1">MKYLVFDVGGSAIKYSLMNDELEMLEKGSEKTPLDSLENFKQVIKGIYEKYKGQIDGIAMSLPGLINRKTNRMQIPGALEYNFGVDILSELKSVTTDRFTIENDAKCAALCEVTYGSLKGTSVGAVCIIGTGIGGGVTIGDNVLTGSNGFAGEFSYFSTNWRDYEGFNSKWAVENSAFTLVSMIAKEKGLKAEELDGIKAFEFCNNGDKAALKALSDYCDIVAMGLWNIQATVDPEKIAIGGGISRQPILMEYINKSLEKVYSKMPIPIPRVQIVNCKFFNDSNLIGALANYKKVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KHR6</accession>
    <name>A0A174KHR6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybjI</name>
        <name evidence="1" type="ORF">ERS852471_02996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267939.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10331">
        <property type="protein sequence ID" value="CUP10331"/>
        <property type="gene ID" value="ERS852471_02996"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP10331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="29865" checksum="E642CD088B208D05" modified="2016-09-07" version="1">MIKLIATDMDGTLLDSNNKINPEFYEVFDKLKEKDVIFAAASGRQYYNLVDRFEDIKDNMMFIAENGTFVMHKGKEIILNSLDKRIAVELIKIGQTIENAYVILCGKKAAYIDKTDKRFMDQVNKYYAKVKIVDDLSKVHDDILKVTICDFGGSENNSYKYFANYNDKVQIAVAGEIWLDMMAKGVNKGLAISEIQKLLNIKQEETMVFGDYLNDLEMMQNAYHSYAMENAHSDLKKVARFIAKSNDDNGVVRAIKEKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KIR0</accession>
    <name>A0A174KIR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267908.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09688">
        <property type="protein sequence ID" value="CUP09688"/>
        <property type="gene ID" value="ERS852471_02980"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2211247at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP09688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7163" checksum="00543DE4A1D15082" modified="2016-09-07" version="1">MAHEKLEKKINGLMKVIKKGRMTEEIADEVSNVIDEIEDLGDAVKKNFSSSLNEMKKALKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLG9</accession>
    <name>A0A174KLG9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11346">
        <property type="protein sequence ID" value="CUP11346"/>
        <property type="gene ID" value="ERS852471_03025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6508" checksum="6A07A43C5E9B86D2" modified="2016-09-07" version="1">MKKCLFCKKELSKDYFENKIGYFCSEDHFDEYLKSLSKEEYVELQNSFCVCSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KM86</accession>
    <name>A0A174KM86_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267969.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10948">
        <property type="protein sequence ID" value="CUP10948"/>
        <property type="gene ID" value="ERS852471_03013"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="146" mass="16873" checksum="748CC723756978C6" modified="2016-09-07" version="1">MERGEVHKSLMKTLRCHHKIFRSEFAKFNISKGQPKILSYLSENDGCSQKDIAKNCDIEAATATNVLSTMEKVGFIERIPNKNDRRILNVYLTDKGKEAQEKAKRTLCDLEEICFRGFSEEEMTMAKDIFDRIYDNLKKGEKSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQE9</accession>
    <name>A0A174KQE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein dppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppC</name>
        <name evidence="7" type="ORF">ERS852471_03033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268011.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12098">
        <property type="protein sequence ID" value="CUP12098"/>
        <property type="gene ID" value="ERS852471_03033"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="31832" checksum="29634E08F93A957B" modified="2016-09-07" version="1">MLKNPSVNLGKKRIQIFSNRRKRIVFYITISVIYLVTILIVGLIMNPDKYAVDYSAKFISPSLGHLFGTDFMGRDMFWRCIKGLSNSILIGIFASVVSSFIALVFGVSSAIIGGWYDRFINWCVDLCMGIPHLILLILISFMLGRGAVGVTVAVSLTHWTGLTRLVRAEVLQVRSAQYVQAAYKMGKSKFQVAISHIIPHVLPVYLIGVVLLFPHAIMHEASITFLGFGLPAEVPAIGVILSEAMKHIATGKWWLALFPGLMLLSVVLLFDVIGENLKQLINPNSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KT09</accession>
    <name>A0A174KT09_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF434)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268021.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12309">
        <property type="protein sequence ID" value="CUP12309"/>
        <property type="gene ID" value="ERS852471_03038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007368">
        <property type="entry name" value="DUF434"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041652">
        <property type="entry name" value="DUF5616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04256">
        <property type="entry name" value="DUF434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18481">
        <property type="entry name" value="DUF5616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF434" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5616" evidence="2">
        <location>
            <begin position="84"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="236" mass="26847" checksum="0A94DE637C03617E" modified="2016-09-07" version="1">MSKISKRGFDLNDKRWFSEKEIIRLRKAHEEIKWLLDRDYKLESIINFVGSRYQFSTRQRDALKRATCSSANELLRKSKEISINDIKGQSLNIDGFNLIINLEVALSGGTLITGDDGLVRDLAGLRGTYKLIDKTDIALDYIFNFLNSIDIESINIYLDSPVSNSGNLKIKIFEYAEKYNLNTSVELVNNADVILEKLNNVVTSDATILDKCISHFNLSKTIIDKYIQDANIISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KWZ2</accession>
    <name>A0A174KWZ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14936">
        <property type="protein sequence ID" value="CUP14936"/>
        <property type="gene ID" value="ERS852471_03089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="2">
        <location>
            <begin position="223"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP14936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="385" mass="44863" checksum="6A3CB3D0FE8731D1" modified="2016-09-07" version="1">MYHNSFSLKIILVLFLAIYNINTICFATPLSKDELTVMKEEILDLKNNTDNSEELKNQFQALLENLFLNRNSAILSKDTEGLKNFYDLTKKVGQWAYENETTKIQYFSNWSEKQGAKFDRINSILKVKKVKEKEPNLFGVICYVSTEFYYNYLDSPSEQNRFKLGTYHYLNLRKEGDRYIITKEWYTDPLADSLNLENIKSDEIKDYILSCKKPEFTINERCQKAIDYAHTYCGVSDNEEFLFKYNPNYRNFNPEGGDCANFASQILYEGGGFKKNDYWNYNKGDATKAWVNAQGFKNYIISSGRGSYIAKGSYQETYKSAFQLRPGDIVAYEKKGRITHISTVTGLDSKGYPLVTCHNTDRLLVPYDLGWSNKNIRFHFIDVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KY22</accession>
    <name>A0A174KY22_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2871)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268109.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14718">
        <property type="protein sequence ID" value="CUP14718"/>
        <property type="gene ID" value="ERS852471_03084"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984060at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021299">
        <property type="entry name" value="DUF2871"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11070">
        <property type="entry name" value="DUF2871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="131" mass="14708" checksum="54B650D055F5A751" modified="2016-09-07" version="1">MKKYVNLSIFYLVLGLVFGVFFREFTKLNGFIGITTLSALHGHALILGFIFFLIVLILDKLFEISKAKAYKGWLIAYNVSLVFMLITLLVRGILQVNGSDFAGLSHIAGLAHTMLGLSFIWFATILYKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L2V0</accession>
    <name>A0A174L2V0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capsular polysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="4">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">capD_4</name>
        <name evidence="4" type="ORF">ERS852471_03131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17016">
        <property type="protein sequence ID" value="CUP17016"/>
        <property type="gene ID" value="ERS852471_03131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="300"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP17016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="636" mass="71390" checksum="E6E319CE4CFE5D7B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L5Z4</accession>
    <name>A0A174L5Z4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_029425405.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18126">
        <property type="protein sequence ID" value="CUP18126"/>
        <property type="gene ID" value="ERS852471_03150"/>
    </dbReference>
    <dbReference type="GeneID" id="45364093"/>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP18126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="164" mass="18859" checksum="237B10E4C095949F" modified="2016-09-07" version="1">MFKEKIIIEMKEVFKEIPFGIEHTLKVLKNAEDIMNGENIGEEEKEFISITAILHDIGAVEAQKKYGSIDGVYQEKEGPAVAKEILKKVGYNKNIDRICFIIGNHHTPSKIDGLDFQIQWEADLLENLTVMDKEKEQEKIKKCIGENFKTNTGKRIAYNRFILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6M4</accession>
    <name>A0A174L6M4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268232.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18491">
        <property type="protein sequence ID" value="CUP18491"/>
        <property type="gene ID" value="ERS852471_03158"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1783195at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="88" mass="10358" checksum="EFA7B60543FFA578" modified="2016-09-07" version="1">MKGIAKPIQMIAWFDEHGKINPVKFKYEEDGCKVICINKILNRSFEKLAGNPMWKFTCSSIIDDSEYTYNLKYDLINSKWILFDRSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L8K6</accession>
    <name>A0A174L8K6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP19026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268252.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19026">
        <property type="protein sequence ID" value="CUP19026"/>
        <property type="gene ID" value="ERS852471_03172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP19026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="17071" checksum="F51140A590CBF149" modified="2016-09-07" version="1">MKDREMKRAKEVIEKGDGRHMYTMEQLLFRLSIKIPNQNINEVIDKLKRLSIVPSAIFKTSCGLIVEWWTMRCQVILDYNNYIKLIKEFLEYVDSIGVNEWIFDTGCLSDSLPVEYDNLEVIINPRFTVENFNNTGEIEINDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L969</accession>
    <name>A0A174L969_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP19067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268255.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19067">
        <property type="protein sequence ID" value="CUP19067"/>
        <property type="gene ID" value="ERS852471_03173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP19067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="121" mass="14152" checksum="63131EC57C5F1934" modified="2016-09-07" version="1">MINEIIKENVLINFDIDINENGKGRDEMAIDTYTIIVPIEAITEEVSLDELHMEFNSCISNVKIAEKKITMDYFTGETTFIRTVSEIQEHIRIMVNSIRNKLANIKIGNFKLVYNFYTWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LFL7</accession>
    <name>A0A174LFL7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268293.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20390">
        <property type="protein sequence ID" value="CUP20390"/>
        <property type="gene ID" value="ERS852471_03194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="79" mass="9505" checksum="A604BF2C989009F4" modified="2016-09-07" version="1">MKEDLKLYRCIFLKENKSYIIGKDIFNSKIYYIKKNEETENFRIGTDNSFYAIKEEYGTLFKKVILNVINYESVIKMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LTW4</accession>
    <name>A0A174LTW4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_20</name>
        <name evidence="6" type="ORF">ERS852471_03292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000039">
        <property type="protein sequence ID" value="CUP26097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268464.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26097">
        <property type="protein sequence ID" value="CUP26097"/>
        <property type="gene ID" value="ERS852471_03292"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP26097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="460" mass="49587" checksum="000B9B418FB6A431" modified="2016-09-07" version="1">MSKENDVLGTESIGKLLIKYSIPAIIGMMVNALYNVVDRMFIGNIPGVGPMAITGLGVTLPIMTILVAFGTLIGVGATTKVSIKLGEGKRDDAEKIIGNSFTLTIILSIIITVFGLLFLNNILTIFGASENTIVYARDYMIVILAGTIFNMFSSIFGNIVRGDGKPKLSAIIMSVGCITNIILDAVFIFVFNMGIQGAAIATVIAQAISTVLGMIYYLGGKSNVRFKKENLKLYKASVAGILIIGVSPFAMQLATSVVQLIYNFSLKTYGGDLAIGAMATVNSISMIFVMPAFGFVQAMQPIVGYNYGAKRYDRARKTLKISLIAATFVFVMGFLLTQFAPEMLVGVFNKDPELMGLTINGLRKYTLAMPVIGISIVGTYYIQSTGKAKMSMLLSLLRQVIILIPLIAIVPRFFGVNGAWFAQPIADIIAAVATGVVLFNEVRKYSKIKDDELSEEVKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFW4</accession>
    <name>A0A173XFW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase expression/formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypD</name>
        <name evidence="3" type="ORF">ERS852471_00036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262722.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50742">
        <property type="protein sequence ID" value="CUN50742"/>
        <property type="gene ID" value="ERS852471_00036"/>
    </dbReference>
    <dbReference type="OrthoDB" id="666873at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN50742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="359" mass="39817" checksum="419E24525B358607" modified="2016-09-07" version="1">MKELISFKNPKLVKEILEKLKRFNNEDITIMEVCGTHTMSILKSGLKELLPQNIKLISGPGCPVCVTPQEYIDMAIELCKKENVIITTFGDLVRVPGTHSSLQKEKALGRDIRVVFSPLDSLEIAKSNLDKEVVFLGVGFETTAPIIALTVYNAKEKGIDNLSILNSLKTMPNVMKSLVSNKELKVDGFICPGHVAAVIGAEAFENLSIEEKLPLVIAGFEPLDIISAIYRLVEMKANGESKLENLYTRIVKNKGNEKALNILNTVFQLSDSQWRGFGIIEGTGFKFKENYKNYDTKNKFNINIVNSQINKGCICGEILRGVKNPYDCKLYGKVCTPVTPIGACMVSEEGTCAAYYKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XII1</accession>
    <name>A0A173XII1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262738.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51443">
        <property type="protein sequence ID" value="CUN51443"/>
        <property type="gene ID" value="ERS852471_00048"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1522031at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032479">
        <property type="entry name" value="DUF5058"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16481">
        <property type="entry name" value="DUF5058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="238" mass="25635" checksum="C5645F69A3A9304E" modified="2016-09-07" version="1">MDGITQLTNSTTMYLISGTIITAVALVCVLFFIRAYKEGIKIGMDKKDLSKVITSSTIFTIVPSIGILLGVITLSGSLGVPIPWLRLSVIGALHYEVMAADMAAKVSGLLALSPEFMTPEILVTIVFVMAIGIIWGSIFCVIGLKKYQSTIKKSTSKDNRWGQLLFNAIFIGLVCAFVGSSFGDVRQGSFTSLIVIVISALSMSICDYLVKKKNQKWLDSFALSISMLIGMAMAILVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSQ2</accession>
    <name>A0A173XSQ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262855.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54764">
        <property type="protein sequence ID" value="CUN54764"/>
        <property type="gene ID" value="ERS852471_00114"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046117">
        <property type="entry name" value="DUF6054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19524">
        <property type="entry name" value="DUF6054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="112" mass="12649" checksum="8C83AB443B5475A4" modified="2016-09-07" version="1">MGIYSFDVKLTLDETIKRLDAGIISGTITEKIDFHEINSQGKNKAVVMVYEKKYFRASNRLTLTLCLEELENKTHIHVIGISGIEKAITGNGEASEKFTSLPREILEDYIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XT40</accession>
    <name>A0A173XT40_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262831.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54126">
        <property type="protein sequence ID" value="CUN54126"/>
        <property type="gene ID" value="ERS852471_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="170" mass="19333" checksum="5C2375ECB3EFC80E" modified="2016-09-07" version="1">MAYDKLIKETNMKNGIEGNISVFMRERVEGKEDGAKVIANVIAGSLDRNYKGQNNYKLLAKKITDKDNSYFEDIAAFAIYIFTMDYTNKMLKDMPEDHNRNVLMKAISTQISRGVAAINMYVANDIKQGVYATHTETTRKIMGISNKFHDAFNNYLNSKKSEIIENLIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XUU8</accession>
    <name>A0A173XUU8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ypwA</name>
        <name evidence="4" type="ORF">ERS852471_00126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55303">
        <property type="protein sequence ID" value="CUN55303"/>
        <property type="gene ID" value="ERS852471_00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN55303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="501" mass="58466" checksum="73FCF9C2F016FCB5" modified="2016-09-07" version="1">MNLEKKFEEVKEYIGEVEYLTHAMVLVDWDTRTNMPIKAGESRSKVLEYLSGQLFNMTTSPKVKTFIEELTPYKNEMSLVQRRILEELERNYNEIMKIPEDRYVASVGATSRAQIAWEKAKEANDYESFKPYLQNVIDFSREFIGYWGYEGDKYNTLLDKYEKGLTVEKLDKIFSELRDGIVEILENIKKSDKKISTDILNGNFDVNKQKELSLCVLEKMGFDLEAGRLDVSVHPFTTNMGNKDVRLTTNYHKDRFASALFSTIHEGGHGIYEQNISDDLENTGLNAGVSMAIHESQSRFYENIIGRSKEFTSYLLNLSRKYFEEFKDVTAEEFYEVMNKVEPSFIRTEADELTYSLHIIIRYELEKDLINGRITLDQLPSEWNKKYKEYLDVEPTSDSVGVLQDVHWSASLFGYFPSYALGNLYGAQIYYTLLKEEPTIMEDIAEGNLNNLHSWLKENIHKYGSIYSPAEIIKRVTGEELNPQYFIKYLKDKYYEIYNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XVH3</accession>
    <name>A0A173XVH3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262863.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54956">
        <property type="protein sequence ID" value="CUN54956"/>
        <property type="gene ID" value="ERS852471_00118"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2191991at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="284" mass="33296" checksum="CB1647AC932E0565" modified="2016-09-07" version="1">MRKKVCPRPQCAKEYLEGEGFDDLTVCKLCGAPLEDVFVDDYDIEEQSDEFEENTDYETDDVIYETDDVICEDDMSYEEDIVDNNDIEDTEETFEDRNCFIDIDIVDDKLKSEVILAEEDVDSDENDDENIEENEAEDIVITEANEEDEEEEDELENTEEVNPYENIKGNNLILYKDNEIFKVYELKYDETIIGRNSSEFTPDIDLQEVDNENAISRKHLLVYKEDDKYYVRNLSKKCSVHIKRYDEDEPKVLSFNESVVIEDGDFIVLSGKFILEAYFNEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWE4</accession>
    <name>A0A173XWE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262861.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54905">
        <property type="protein sequence ID" value="CUN54905"/>
        <property type="gene ID" value="ERS852471_00117"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692608at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="52"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="474" mass="53181" checksum="45DC4F147FCFA7FA" modified="2016-09-07" version="1">MAGELVLETKISDPYILCDDKEHVVKACLSVYASDEVKERLEGEKQINNGVDLCLLIDVSGSMFKIVGGETTPTGKKQIIDGVKYNIVTGGTTKLDIALEAVNKVVELLRPTDNVTVIAYDDTPHIIVQNLPGSDKERITEALEKCKDYSGNTNISEALKLGRLILNNNNNGKIKKMIFMTDGVPYGDTEEAGIRQAKLIAETGISIDCLGFGGSDVNFAFLEKLAKPSNGRTELINEPEEARDMFTELFENSTEVIITNAKLELTFPKYVRVTEHYKGTPEVAYLGKVVLDKERKATVNLVNIERNQEYKFYFLMTIPGRSSGDSSLEIMSAKLEYYIPKLYGNRNFFIVRNVSVDVGDNTSLVEKDGEVERGYYEAEIKKLEDEANIARERNDYNTAIKRYEWIINRYEELGNALAVNQYRALIDEFRENGTISIQAINNAGKTSTRPVNSATTTIKIDFPTNATLRRRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YFG8</accession>
    <name>A0A173YFG8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="3 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pyk_1</name>
        <name evidence="14" type="ORF">ERS852471_00241</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263091.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61528">
        <property type="protein sequence ID" value="CUN61528"/>
        <property type="gene ID" value="ERS852471_00241"/>
    </dbReference>
    <dbReference type="OrthoDB" id="863122at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="3"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="39648" checksum="77EC917288334394" modified="2016-09-07" version="1">MDLICSIGPTVRNIEDIKKFVQAGMTMPRFNFSHIDYDKFKTLINEIHIEFPNMKILQDLQGNKLRISKFFVGEYRVNINDRVIFCLEKDYKDLYEKNRYKNIKIIPIIYYGSLTDFINVKELYMKDATMRFKIIKKGSLYIQAITIKGGILRAEKGINAPGLIRDKLSLTSKDKQDIEIGIQNNIDFICLSYVTKADDIIELKQYVKALVKHYKSKSPKVWAKIECREGIDNFEEILKVSDGIMLGRGDLKAEIPIEDTPYVEEKIITRMKKSKKKLIVATYILESMRRQDTPTISEVNDIYKFIKNNVDGLMLSTEVAVTREPVMVIRCLNNLYSKYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMJ8</accession>
    <name>A0A173YMJ8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yrrK</name>
        <name evidence="4" type="ORF">ERS852471_00271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263165.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64919">
        <property type="protein sequence ID" value="CUN64919"/>
        <property type="gene ID" value="ERS852471_00271"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN64919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="139" mass="15427" checksum="434B7ED0200A34FB" modified="2016-09-07" version="1">MRILGLDVGSKTIGVALSDPLGWTAQGITTIRRTKKEQDIEEVHKICKEYGVETIVIGLPKNMNGTIGESGERVIALAEVIKEKTGLPIEMWDERLTTVAAHRAMLEADLSRGKRKKIVDKIAAIYILQGYLDKLRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMM5</accession>
    <name>A0A173YMM5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SecC motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">secA_1</name>
        <name evidence="2" type="ORF">ERS852471_00254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263139.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64038">
        <property type="protein sequence ID" value="CUN64038"/>
        <property type="gene ID" value="ERS852471_00254"/>
    </dbReference>
    <dbReference type="OrthoDB" id="838815at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="1">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="375" mass="43865" checksum="04449BC3903351EB" modified="2016-09-07" version="1">MADNNKIQEEIIKADIKAVERLWKNSIQDNLLESLLEKMTKEELVKVAKKYSIKGLTSLKKADVVERIKNGILEKYEQALDVIDEDTLKFIEELIENNGQKLYSCNDIIYSNYLRNRGLVFTGTVDDELFVILPKELIELFKEKINKELYQKARLNREIIRAIAGMIYYYGVMDITSIKENLERVFVCEFDLGFIKTIALTGEELGYDYVVDEEVLYHIDVEDVEKLIKDQSLCQNDYYKFDKKSLIKAGEPDFIEENKQAEKLKKVFRELFVIDNNILREEMDSFIIAIKNEMSKDEAIEAFLEAYEIESDEEKDIFKHELDVFARSIRRWTLKGNNENEIKKNEQRVVNEVKIGRNDPCICGSGKKYKKCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPU3</accession>
    <name>A0A173YPU3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein, YlmC/YmxH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263195.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65689">
        <property type="protein sequence ID" value="CUN65689"/>
        <property type="gene ID" value="ERS852471_00287"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1995157at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014238">
        <property type="entry name" value="Spore_YlmC/YmxH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40061">
        <property type="entry name" value="PTHR40061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02888">
        <property type="entry name" value="spore_YlmC_YmxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10509" checksum="3BDFC75864C75B8A" modified="2016-09-07" version="1">MDEDLVLFSTNAIRSMEVIDISTGSKLGYVKDFRVDVNEQRVISLTLPSPTKSWFGKEEDIEVPWEKVIKLGVDVLLIDGSDIQRELEQNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBN6</accession>
    <name>A0A173ZBN6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">rnfA</name>
        <name evidence="9" type="ORF">ERS852471_00424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263437.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73079">
        <property type="protein sequence ID" value="CUN73079"/>
        <property type="gene ID" value="ERS852471_00424"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1814639at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN73079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="20999" checksum="3BBE0F088F3424C3" modified="2016-09-07" version="1">MKEMMIILVSAILVDNFVLAKFMGICPFLGVSKKIDSALGMSAAVTFVMVMASAVTFPIYQILNKYELGYLKTVAFILVIATFVQLLEIVLKKFMPPLYKALGVYLPLITTNCAVLGVTVLNIDNGYNFLQSIVNALGAGLGFTLALILFSGVRQKMENTDIPKAFKGLPITLIAAAILAVSFVGFSGVVDGLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCH3</accession>
    <name>A0A173ZCH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Di-trans-poly-cis-decaprenylcistransferase UppS</fullName>
            <ecNumber evidence="2">2.5.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS1</name>
        <name evidence="2" type="ORF">ERS852471_00441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263468.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73981">
        <property type="protein sequence ID" value="CUN73981"/>
        <property type="gene ID" value="ERS852471_00441"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155071at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008834">
        <property type="term" value="F:di-trans,poly-cis-decaprenylcistransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24346" checksum="F3E8E18FFF68777E" modified="2016-09-07" version="1">MRIPNHIGIIPDGNRRWAESKGFSKEKGYSLGGITPGLLLFKLCQKAGVKEITYYGFTTDNTKRPSIQKAAFIKACVDAVKILSNEDAELLVVGNTESKSFPKELLPYTTRRVFGKGGIKVNFLVNYGWEWDLYSLKSTSNKSKSIMPTIHSSEISRIDLIIRWGGRRRLSGFLPVQSVYSDFYVVNEFWPDFKPEHFYNALDWYNDQDITLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJJ0</accession>
    <name>A0A173ZJJ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase/N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="2">4.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nanA</name>
        <name evidence="2" type="ORF">ERS852471_00472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263523.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75646">
        <property type="protein sequence ID" value="CUN75646"/>
        <property type="gene ID" value="ERS852471_00472"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="34774" checksum="2A91AC9BD610719D" modified="2016-09-07" version="1">MNKFDIKDFKGVIPAVLTVFDKDENIDELGMRQLVSYLIDKGVDGLYLTGSTGEGFTMSSEERKRVVEIVMDETKGRVPVVVHVGAIGTKLSIDLAKHAEEVGATGISSVPPFYWKFNENQIVKYYEDIANSCSLPMIVYNVPLVGLLGMNVIKCLAQIENVKGIKYTALSHYEITQIKDEIGEDFLVYSGCDEMSMSGLLAGADGIIGSFYNIMPELFINIYNSIKENNIERAQLLQRQAVEIIMYSLKLPSFYAGMKAVLRWRGINAGYCRRPFENLTEEAENEFKEGYIKLRDTYKITGVEFLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ARW7</accession>
    <name>A0A174ARW7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lipB_2</name>
        <name evidence="1" type="ORF">ERS852471_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90218">
        <property type="protein sequence ID" value="CUN90218"/>
        <property type="gene ID" value="ERS852471_00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN90218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="174" mass="20020" checksum="91624ED31287ED6C" modified="2016-09-07" version="1">MSRKYSQDLLNKIVERQELVNIKGVEVLVKNLPDSDEKGAMDPRLYKDMKKQMTIMRFMPKSMTKMDTSAKGIEKLRKMFGEIKSIPIVEKEIDIINKTVKADDGYEVPVRIYKSETIKENAPILYYIHGGGFFGGSPDVVEELVKLIVEKNRHIGFFSRLQISSRKSISNRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B801</accession>
    <name>A0A174B801_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycgJ_1</name>
        <name evidence="2" type="ORF">ERS852471_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264296.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95738">
        <property type="protein sequence ID" value="CUN95738"/>
        <property type="gene ID" value="ERS852471_00710"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29316" checksum="C040B08F5189118E" modified="2016-09-07" version="1">MKLDEIYEYFNEEKRLNTSNASSIEFITTTNFIDKYLKEDSKILDIGAATGAYSLHYASKGYDVTSVEPVKRNIDILKSNVTGDMNIKVHQGNALDLSYLEDNSFDIVLCFGPLYHLKSDEDKLTAIKESKRVCKKDGKILFAYLSNDMVFVTETFIYNTKNHLLGDEYDKESFKLIDETPFCFMTVGKMDELMRKSNLNKVTQFAADGLAELMADKINEFSEAEFNEWMRFHLYTCEKTELLGYSNHIVFVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B836</accession>
    <name>A0A174B836_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmuC_1</name>
        <name evidence="11" type="ORF">ERS852471_00711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95798">
        <property type="protein sequence ID" value="CUN95798"/>
        <property type="gene ID" value="ERS852471_00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="39"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN95798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="466" mass="51375" checksum="D1338E78F0132E8F" modified="2016-09-07" version="1">MENFPRVGIQIWNKIRIIKLENVIKNEGEIKMNFISRFIEEKMVPVVSRFANLRYMRALKSGFMVIMPLTIIASVFLLITDFPINGYPEFMARIFGEGWDSFLSPAYRATFDIMGIMLAGTIAYKLSEDDKMDPLPVMIISIVAYVIVTPKFVTAESGEVINKVLPMAWLGTKGVITAIIMSITSTELYRFVVKKNLVIKLPENVPPMVYKSFVSLIPGVIVVAYALLINGIFLSMGTSMHEFIYDILQVPLQGLTASPAAITVVAGLNGFLWWFGIHPTVVNSIVNPLLNANSVENLELFKQGALTLENANIGTIQMIDQFATIGGAGMTVGLVLAMVVVARSERMKMMRNLSTVPALFNINEPIIFGLPVILNPLMLIPLTLAPIVSVLIAIFAMKIGFLSPFNGVVAPWPTPPIFSGFLVSGWQGALVQVVAIAAAFAIYYPFVLALDKQYRAEELTEELIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBK7</accession>
    <name>A0A174BBK7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl_1</name>
        <name evidence="7" type="ORF">ERS852471_00734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264028.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97130">
        <property type="protein sequence ID" value="CUN97130"/>
        <property type="gene ID" value="ERS852471_00734"/>
    </dbReference>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN97130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8366" checksum="CC37A93CD9F71F64" modified="2016-09-07" version="1">MQRKVNNISKEIWDLLGCKGYARIDMIISNGELYLLEINTLPGMTKSSLIPKSAEAVGMSFTELLDRIIEYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDZ4</accession>
    <name>A0A174BDZ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp_1</name>
        <name evidence="8" type="synonym">pfp</name>
        <name evidence="10" type="ORF">ERS852471_00748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264059.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97848">
        <property type="protein sequence ID" value="CUN97848"/>
        <property type="gene ID" value="ERS852471_00748"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="6"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN97848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="405" mass="44432" checksum="50DB21B1F68DEF83" modified="2016-09-07" version="1">MANCIIAQSGGPTSVINSSVVGLIDANKDLKIFDKVYAGLNGIEGILNGNIIELSSFSDEEINSFRYTPSSGLGSCRYKMKKLEESTEEYDKLLEILKANDIKAFFYVGGNDSMDTTAKLGKYAKETGLDIKFIGIPKTIDNDLMYTDHTPGFGSAAKFIATTVLETYLDSSVYINNGIFIVETMGRDTGWLAASAALAKLNGKQVADFIYLPESAFDVDKFLHDVKLKFEEQNQVYIVVSEGIRTADGTFVAETSSQAHDKFGHAQLGGVGMYLKNLIIQSGITKRVKSLELGVLQRCAMHCASSLDLEEAHQVGYEALKYANMGHSGYMVAIKRDSNAPYSSSYFLVEADKIANNVKYFPKEWINEEGNGVTEEAIEYLAPLVSSLPSILTQSPMPNFKVFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIF0</accession>
    <name>A0A174BIF0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264147.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00293">
        <property type="protein sequence ID" value="CUO00293"/>
        <property type="gene ID" value="ERS852471_00794"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO00293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="24422" checksum="BF82D8845E52E4E2" modified="2016-09-07" version="1">MMNIELVIFDMDGLMFDTETVSREAWKIAGEKVNMPVDDELFSEFLGTNSKYITNLLINKFGEKSPYKELISERNIMADKLIDMNGLRVKKGLKELLAYLKENNIKRAVATSTSRARALKLLTLGEVVNEFDYIICGDEVTKSKPDPEIFLKVAEKLNVLPENCIVLEDSRFGVYAAKNAGMYPIMVPDLLTPDEELLGMIYKKADDLGQVIELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BLY1</accession>
    <name>A0A174BLY1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264197.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01563">
        <property type="protein sequence ID" value="CUO01563"/>
        <property type="gene ID" value="ERS852471_00818"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="24871" checksum="703097CD0946E326" modified="2016-09-07" version="1">MTYNIEDLYEAYPVLKKVDRSFNGVISKKVIYKELLASEHLTTNGTSCTGFLFVLSGDIKIQRIGYDGEETNLYNIGRGELCHEALSCFLKCEPLNIIGKATQDSRICIIPFDIVENYLLNNVDFLKEMYRDLHSKFNLIIGTKEEVKHESLQKRLVKLLISKKSKNIYATHAEIAFELDSAREVISRRLKELEKEGYVKLTRGKIQIIKDLNELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQP4</accession>
    <name>A0A174BQP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rhaS_1</name>
        <name evidence="5" type="ORF">ERS852471_00827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264213.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02010">
        <property type="protein sequence ID" value="CUO02010"/>
        <property type="gene ID" value="ERS852471_00827"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="287"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO02010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="389" mass="45414" checksum="7F5E54566B6DC532" modified="2016-09-07" version="1">MYDKTSSAQFKKYGSIYDEPKDLHSDELIQREVVTTDRVISSLYHFSEPVYVEVKDGMAYILIGDSSDGEFKLFGIHRNLEIKANMYFNIIPMMDQVKFNLIIPPNYNLNIEFLNPPYEYNRILPTINIPEIMAYYYTIKSPNYKFKGERHNIYELTFVDNGTLETSIDNVSYTLNSYDLIIYGKNQLHTQNVNSDSSCSYLTVMFDMECKDDSLICNRVFHCRKELYKAIRTFAKNISSTLPYTQNLILSNFHEIIIRLFQYDYLGTESDKLPTETQQYFQDELLEGILAYIDKMVCEPITIEELCGKFSVSRSSLQTLFKNNLNTSPKKYINDLKLAKSKLLIKENKYTISEIAFMLGFSSIHYFSRAFTQHFEISPSEYAQTVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3P9</accession>
    <name>A0A174C3P9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)</fullName>
            <ecNumber evidence="2">1.21.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grdB</name>
        <name evidence="2" type="ORF">ERS852471_00909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.21.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264381.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07764">
        <property type="protein sequence ID" value="CUO07764"/>
        <property type="gene ID" value="ERS852471_00909"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1464559at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030699">
        <property type="term" value="F:glycine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010187">
        <property type="entry name" value="Various_sel_PB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07355">
        <property type="entry name" value="GRDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01918">
        <property type="entry name" value="various_sel_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO07764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="18936" checksum="6D1C96AA9B75090F" modified="2016-09-07" version="1">MKVLMIFDQTQAGLGGKENPNLELGGKMMPIGSASMLEPALKEVDGKVVATLYCGDGFFDENKQEVTKKIIAMTQKINPDVIICGPAYNYKGYAKMCAVLAKALNRYTKIPAIAAMSQENDETIAEYKDVINIVKMPKKGGTGLNDSLRNICRLAKKKANGEDVTEYAKQICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C927</accession>
    <name>A0A174C927_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264419.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08759">
        <property type="protein sequence ID" value="CUO08759"/>
        <property type="gene ID" value="ERS852471_00928"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2207672at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="88" mass="9597" checksum="882F0EF52251E1D2" modified="2016-09-07" version="1">MSSCGKDRKRKGKSKRSDIDLTSILTFIKLIQAIGCGMLGISVLGLILVGKNPSAQVLYIMVIVVNLIIVFGGLFPIRYLTNKVSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCC1</accession>
    <name>A0A174CCC1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidA_1</name>
        <name evidence="1" type="ORF">ERS852471_00944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264451.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09610">
        <property type="protein sequence ID" value="CUO09610"/>
        <property type="gene ID" value="ERS852471_00944"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO09610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="31643" checksum="878C93E9B92EC8B2" modified="2016-09-07" version="1">MKYKMVCIDMDGTLLGKRKKISEFSKDIIKKAHDMGVEIVVTTGRLYNNAAYFSQLLGVDSPVIAANGAIVIDQKTNDIIYESAIPEVECMKVLKILNKYKVPFHFHTTDTIYCNNWFSKLGTQVYMTKQVYYEHLNINYYTVKTEKEWAEIFKKENGRMAKCIAFSPSSKDILKVRKELDSLENIVYFGSGNHSTEINFKGVSKGNSVKVLSEKYGIKREEIICIGDNENDVSMIKYAGLGIAMANAIDEVKSAAQYITDSNKNDGVAKAIKKFILDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHK0</accession>
    <name>A0A174CHK0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264507.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11235">
        <property type="protein sequence ID" value="CUO11235"/>
        <property type="gene ID" value="ERS852471_00977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="35287" checksum="C964D7A779680151" modified="2016-09-07" version="1">MDNRYVEKKYIKALNKNLPFFQALASDTRLKIISLLQNKEMSIKELSSALNISSAVVTKHINILEEVDIIESYSQPGVRGLLKLCKIKTNEVQIILNNNYEEINKNFIEIDIPIGAYSSFKISPPCGLSLKDKLFGVLDDPRYFAAPNRIDLSLIWFTSGYLEYPIPTYDINFNNLVEMEISLEICSEFPGYNNSFKSDIYFYLNNIPLGKWISPGDFGDRKGVFTPNWWNLGSEYGLLKTIKINNTGVYLDGIKLSSTPLSEFLKEDNDALLFKIECPADTHNPGGINIFGKNFGNFDQNIKVKCHYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVQ7</accession>
    <name>A0A174CVQ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264577.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15898">
        <property type="protein sequence ID" value="CUO15898"/>
        <property type="gene ID" value="ERS852471_01042"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1949099at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="15534" checksum="39A73004A86092D4" modified="2016-09-07" version="1">MAVHLITYFMQQRTHAHSESCGCGDEHHHEHNDNCGCGEDHHHEHSDSCGCGEDHEHGEDCGCGGDPDYDLVCTIETLGKWAQFTPTGFLVVSDLNSDEILEKLRPTVDTRDIIFVTKVDPQDVACTIPQCKDWIVSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXF4</accession>
    <name>A0A174CXF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264592.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16759">
        <property type="protein sequence ID" value="CUO16759"/>
        <property type="gene ID" value="ERS852471_01059"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1975869at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="13285" checksum="2E16D7B92CD775D1" modified="2016-09-07" version="1">MKKENFVSLIIGTVGLVLFALGMCMAMITEWNTFNQDIVVGTIGFIILIIMLIVRRKMEGKPAIELNKKAIGIVLLGIVGALLLGVGMCMTMVWQGLMVQGIIVGLIGIIILLCLIPICKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXL8</accession>
    <name>A0A174CXL8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nikB_1</name>
        <name evidence="7" type="ORF">ERS852471_01049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264584.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16306">
        <property type="protein sequence ID" value="CUO16306"/>
        <property type="gene ID" value="ERS852471_01049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO16306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="314" mass="35039" checksum="679ADD864CBFD66A" modified="2016-09-07" version="1">MIKYICKRFLQLIPILFGITFITFAMMNTTNVDTVDKLLENTGGVVSQQVEDDMRSELGLDKPFLVQYGNWMLGIFKGDMGESYVSGKSVFSTIISKLPNTFLLMASSILLTILIAIPLGIIAAVFQNRFIDYIIRFLSFIGNSLPGFFLALLLILLFSVKLKWLPIIGSSSGTNLKSLIMPTLTLSVAMICKYIRQVRAVVLEELNKDYVKAAYARGIGVKSVLLKSVLRCSLMTIITLLTLSIASLLGGTAIVETIFMWDGVGKLAVDSINMYDYPMIQAYVIWMAFIYVAINLISDIVHHYLDPRIRLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CY12</accession>
    <name>A0A174CY12_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
            <ecNumber evidence="10">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_01064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EC" id="3.6.3.44" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264597.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16989">
        <property type="protein sequence ID" value="CUO16989"/>
        <property type="gene ID" value="ERS852471_01064"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO16989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="577" mass="63347" checksum="4D14379F04BB0E35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4E6</accession>
    <name>A0A174D4E6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264626.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19169">
        <property type="protein sequence ID" value="CUO19169"/>
        <property type="gene ID" value="ERS852471_01106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="13588" checksum="BA836378A543CFF7" modified="2016-09-07" version="1">MIFNGDLFINVIFKTIEGGALPGDGTVTIFGSMRHQTQIVPIGGCIDIDCENFKKCDKDIYAKLVDVCILENHILQNPSLTPAGIPVYSELREQVCIKIKAKVVSDEIVNINLDVKEDKCCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7T0</accession>
    <name>A0A174D7T0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hmpT</name>
        <name evidence="2" type="ORF">ERS852471_01121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264640.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19956">
        <property type="protein sequence ID" value="CUO19956"/>
        <property type="gene ID" value="ERS852471_01121"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637464at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="19797" checksum="6AAFC8A4B2BB17A5" modified="2016-09-07" version="1">MTTNSKQKFNAKEIAMYGLFIALVYVATRFINIPGPTSGGLFHLGNVMFFTIAMVFGKKAGAISGGIGMALFDLTSAWVVWAPFTLIIRFIMGYAIGTWSFKEANSKKQSIFYTGIGLALAFITMILGYYITEGILYGNWIVPLQSIWGNTMQCIVGTVIAVPVSVALKAGFKVRHIKTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9N0</accession>
    <name>A0A174D9N0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264689.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22472">
        <property type="protein sequence ID" value="CUO22472"/>
        <property type="gene ID" value="ERS852471_01175"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO22472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="24880" checksum="1F741E17E74FD1F0" modified="2016-09-07" version="1">MIEIRDVYKEFSNERINFSNIKFEDNKSYVILGPSGCGKSTLLNIISGNIKADGGTITIDIDNSLYNLEKLSSEELQKYRRDNISYVSQEFNLFNDFTVKDNLKLIEKVKGKRISIEEALDVVSLKNKVNQKVKTLSGGEKQRVCIARALLQEGKILLCDEPTGSLNQALANDIIKSLIDVHKKNKNMLIVVTHDDRLIENFDCVIKYDDFIKMNIGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DD71</accession>
    <name>A0A174DD71_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264704.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23227">
        <property type="protein sequence ID" value="CUO23227"/>
        <property type="gene ID" value="ERS852471_01192"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2097665at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO23227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="83" mass="9739" checksum="4C58415FAE62A2BE" modified="2016-09-07" version="1">MVLVSCPLKQDDIVKLIEEHRINDEKVFALHNRKGVNLYFDSKIENDEEASLIIKKIIKSYKYSSALMYNVVTCDGEKINWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS65</accession>
    <name>A0A174DS65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaZ</name>
        <name evidence="2" type="ORF">ERS852471_01271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264823.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28284">
        <property type="protein sequence ID" value="CUO28284"/>
        <property type="gene ID" value="ERS852471_01271"/>
    </dbReference>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="259" mass="29679" checksum="9CFAEDE1069A6B68" modified="2016-09-07" version="1">MKEIKRYLESRIGTYGFFFEDLKSGYVYGYNENVSMTAAGCMKLPIAVSLIKAVEDGKVDFLDKIKIQSEDKVYGTGIIHEFNEREYTVFELLVIMLIQSDNTAANKIIDILGMEKINQDILEMGLKNTKLNRKTTDERDNHTDIENLTSAYDLNLIWKHLYNGTFLNKDNGQMLIDILRRQQIKNKLALYLCDDLKYEISSKTGDKYGVENDTEFIQLPKGDFAFTVLSSGLPNSVYGTVTLAKCGKMMWDEIANNWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DUR5</accession>
    <name>A0A174DUR5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">ERS852471_01290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264859.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29213">
        <property type="protein sequence ID" value="CUO29213"/>
        <property type="gene ID" value="ERS852471_01290"/>
    </dbReference>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO29213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="38895" checksum="F58E14E5AB964603" modified="2016-09-07" version="1">MKTSDFNFDLPEELIAQHPLEKRDYSRLMVLDKKTGEIEHRHFYDILEYLKEGDTLVLNNTRVMPARLFGQKEETGAKIEFLLLKRIEGDKWECLAKPGKKAKIGATFTFGEGKLKCKVVDIVEEGNRIIEFSYDGIFEQVLDELGEMPLPPYITERLDDRERYQTVYSKEKGSAAAPTAGLHFTEELLEKVREKGVNIAYLTLHVGLGTFRPVKVDDVNEHVMHSEYYCLSEEDADIINNTKKNGGRVISVGTTSTRTLETIGDENGYVSAKSGWTNIFIYPGYKFKVVDNLITNFHLPESTLIMLVSALAGKEHVMNAYNEAVKEKYRFFSFGDSMFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVL5</accession>
    <name>A0A174DVL5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tgt</name>
        <name evidence="6" type="ORF">ERS852471_01291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264861.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29267">
        <property type="protein sequence ID" value="CUO29267"/>
        <property type="gene ID" value="ERS852471_01291"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="14"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="256"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO29267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="380" mass="43244" checksum="325D63F209FEEB4F" modified="2016-09-07" version="1">MSKKRYTLLKKDGNARRGRFETPHGTIETPVFMNVGTLAAIKGAVSSMDLKEIGCQVELSNTYHLHLRPTDKVVAKMGGLHEFMNWDRPILTDSGGFQVFSLAGMRKIKEEGVYFNSHIDGKKIFMGPEESMQIQSNLASTIAMAFDECIPNPSTREYVEKSVARTNRWLDRCIAEMNRLNSLPETINKEQMLFGINQGGCYEDIRIEHAKHLASLDMDGYAIGGLAVGETHEEMYRVIEAVVPHLPEDKPIYLMGVGTPENIIEAVDRGVDFFDCVLPARNGRHGHVFTGEGKINLFNAKFELDNRPIDEGCQCPACKHYTRAYIRHLFKAKEMLAMRLCVLHNLYFYNKLMEDIRAAIDAGNYKEFKEQKLREWNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E010</accession>
    <name>A0A174E010_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Citrulline cluster-linked protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">queT</name>
        <name evidence="2" type="ORF">ERS852471_01334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264935.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31093">
        <property type="protein sequence ID" value="CUO31093"/>
        <property type="gene ID" value="ERS852471_01334"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1453082at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="172" mass="18824" checksum="D12314DF90ECE3EF" modified="2016-09-07" version="1">MNQNLTKRIVVTGVIAALYAVLTLILAPISFGPVQFRLSEIMVLLAFVDPLYILGLTLGCLLSNILGGYGIMDVVFGSLATFMSCVVIYWTKNTIKNIKVSLLVSSIWPTIFNGLIIGWMLHITINVPMLITMLQVAFGEFIVVTVIGVPLGSLLAKKYGRYFLKLGLAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0L1</accession>
    <name>A0A174E0L1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative autoinducer prepeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264931.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31007">
        <property type="protein sequence ID" value="CUO31007"/>
        <property type="gene ID" value="ERS852471_01331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009229">
        <property type="entry name" value="AgrD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04223">
        <property type="entry name" value="quorum_AgrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="41" mass="4465" checksum="20CBBB6F544701BA" modified="2016-09-07" version="1">MKKKILTGIATIATLVASVVATSACIWGWYQPEEPACLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4C9</accession>
    <name>A0A174E4C9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264925.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30900">
        <property type="protein sequence ID" value="CUO30900"/>
        <property type="gene ID" value="ERS852471_01328"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1737605at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035168">
        <property type="entry name" value="DUF5317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17248">
        <property type="entry name" value="DUF5317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="21098" checksum="E21B1011BFCF7C92" modified="2016-09-07" version="1">MIETILIAFIVSKIKGFDIKPLFKTWTIYPTILLELLYLIGQAMIFLENYEAIRYMGVMKSAYLCSYLFLVFKYEIYWSAIIGAVFTLLGGLLNDIVIKANGGFMPVYPTISCLTGYVNKDTLNLVDNLHILGSEATKFKILTDYIDLGYSILSIGDVLIRIFVFLIIFNSIRKINVQTKEELKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5S4</accession>
    <name>A0A174E5S4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtK</name>
        <name evidence="2" type="ORF">ERS852471_01354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264973.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31888">
        <property type="protein sequence ID" value="CUO31888"/>
        <property type="gene ID" value="ERS852471_01354"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="452" mass="49620" checksum="C983FB5218550172" modified="2016-09-07" version="1">MLISKEKNFYKLIMSIALPIAVQNLINFAVGMIDTMMLGSLGEIQLSAAAIGNNLFFILMVLMFGLAGGSNILISQYWGKGDVKSIHKILALMYRVCIVITSIFIGIAMFIPSMFIKLYTSDINVIEAGSAYLRIVAIGYIFYAITNCTIMILRSVKTVRISLVVYTASLVVNAFFNWVFIFGKLGAPALGVKGAAIATVIARITEFTIVMCFMVFFENKINLKVKHLLKVDKVILKDYIANCTPVLFNELLWSSGSTMISIIIGRLGTETVAANSISNVVFNFVTVFIFGLSNATAVIIGNTIGEGKNDKAREYARTIGVLSVLMGIMAAIVIQIIKPFVVDFYNVSELTKSIAIDLMSVTSIIVIFQSLGINLMMGVLRGGGDAKFVLINDIIFMWVVAIPLGFIAAFILNWPVAVVFFIVKSDEIIKSIISVIRVFSGKWVRNLTRDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E791</accession>
    <name>A0A174E791_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein ERS852471_01353</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaaA_1</name>
        <name evidence="2" type="ORF">ERS852471_01353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264971.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31850">
        <property type="protein sequence ID" value="CUO31850"/>
        <property type="gene ID" value="ERS852471_01353"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1361974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="29887" checksum="3C72F71DAC96FBDC" modified="2016-09-07" version="1">MLMIISPAKTLDFTKENKAGYSSNTIFNNEINELVEVLNKYNIDELASLMKMSEKLAEENYNRYQKFFTDEIACKEALLAFDGAVYRGIASESFDKKDLEFAQSNLRILSGLYGIIRPLDMIKEYRLEMGTKIKFKTYRNLYNYWEDKLTKFILEEIEKSYGDKVLINIASNEYSKVLDLKEINKVYKVINVEFKEKKGEEYKVVGTYAKKARGLLVNYIIKNKITNVEDIKLFDKDNYILNNELSSDTELIFTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E8Q8</accession>
    <name>A0A174E8Q8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="6">6.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purL</name>
        <name evidence="6" type="ORF">ERS852471_01379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265023.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34164">
        <property type="protein sequence ID" value="CUO34164"/>
        <property type="gene ID" value="ERS852471_01379"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26038at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010141">
        <property type="entry name" value="FGAM_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01857">
        <property type="entry name" value="FGAM-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="5">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="440"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1248" mass="139595" checksum="8005B7878A7B29D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBV8</accession>
    <name>A0A174EBV8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="primary">glmU_1</name>
        <name evidence="15" type="synonym">glmU</name>
        <name evidence="17" type="ORF">ERS852471_01409</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265067.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35332">
        <property type="protein sequence ID" value="CUO35332"/>
        <property type="gene ID" value="ERS852471_01409"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="16">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="250"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="456" mass="49612" checksum="FD1528956303D23A" modified="2016-09-07" version="1">MYKCALILAAGQGTRIKSDLPKVLHKVCGKEMVNHVIDTLRKADISDINVIIGKGSELVKEKTSSREVSYSLQAEQLGTGHAVKCAIDFLKDKKGTVAIFCGDAPLITEETVVSLFEEHNSNNNKATLLTSILDDATGYGRIIRDGNEVLKIVEHKDCNEEELKVTEMNAGVYCFDIEKLLEALDKLSNNNSQGEYYLTDVIGILKSQGEKVGAVVIDFEETLGVNSRAQLAQVEAILRKRINAKHMDNGVTLIDPNNTYIGADVIIGKDTIVYPGNVLEGNTVIGERCTLYPNSRINNSTIENEVEIQSSVILDSKIGDNTTVGPFAYIRPDSVIGSHVRIGDFVEIKKSIIGNNTKVSHLTYVGDAEVGESCNFGCGTVTVNYDGKNKNKTIIGNNSFIGCNTNLISPVKVEDNTYIAAGSTITDDVKTGELAVARAKQRNIPGWVEKRGLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EC83</accession>
    <name>A0A174EC83_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 12">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">murC</name>
        <name evidence="17" type="ORF">ERS852471_01412</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 12"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35482">
        <property type="protein sequence ID" value="CUO35482"/>
        <property type="gene ID" value="ERS852471_01412"/>
    </dbReference>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase" evidence="14">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="116"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="317"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="458" mass="50776" checksum="7FD6C9562192FDF0" modified="2016-09-07" version="1">MSFNLNTDKNKKVHFIGIGGVSMSGLAAVLLTKGYKVSGSDAKESEVLNKLRKSGAEIYIGHNKNNIKNVDLIVYTAAIPASNPEIIEAKEKNIELMDRAEFLGYIMKGHKYNVAVAGTHGKTTTTSMLSHITLNANLDPTILVGGDVDAIHGNFKIGESEYFITEACEYKASFLKFFPYIGIILNIDADHLDYYKDINHIEDTFKKFSDLIPSDGYLVGCAEDARVMEVLNYAKCNTISYGINKGDVTARNIKFNNRGCASFRVFKDDTYLFDIELNTTGSHNILNALASICTSLILNIPHEYIVEGLFDCKGAHKRFEHKGEFNGATIIDDYAHHPVEIAATLSTAKIIPHKKIYCVFQPHTYTRTKTLFEEFTNCFKDSDELILMDIYAAREKDTGLISSDQLGDAIRATGLNCINLHTHKDVADYLASKVEKDDLILTVGAGDVVKVGELLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEC4</accession>
    <name>A0A174EEC4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265045.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34759">
        <property type="protein sequence ID" value="CUO34759"/>
        <property type="gene ID" value="ERS852471_01397"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2006597at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025490">
        <property type="entry name" value="RNAbp_HP1423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038881">
        <property type="entry name" value="RNAbp_HP1423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="86" mass="9671" checksum="300C27A4B2DE40BC" modified="2016-09-07" version="1">MRLDKYLKVSRIIKRRTVAKEACEGGRVSINGKVAKPSTVVKEGDIIEIAFATRSLKAKIVNIAEHVRKENAKAMYEILEGEEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFG3</accession>
    <name>A0A174EFG3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mg-dependent deoxyribonuclease TatD family</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycfH</name>
        <name evidence="1" type="ORF">ERS852471_01433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265111.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36443">
        <property type="protein sequence ID" value="CUO36443"/>
        <property type="gene ID" value="ERS852471_01433"/>
    </dbReference>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO36443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="30185" checksum="AA0D541911C81653" modified="2016-09-07" version="1">MEPKYKIFDTHAHYDDEAFDEDREEVLKQIQEAGVIGVLNCACSRKSLTTTNELTLKYDFIYGALGIHPSDAYDYNEDVRAEIIEKANSNKKILAIGEIGLDYYWEENPDRETQKRVFREQMELARELKLPVVIHDRDAHKDTLDIMKEYPEVKGIVHCFSGSVEFAKECVKLGYYIGVTGVVTFKNAKKIVEVVDEIPIDRLLVETDCPYMAPVPNRGKRNKSDYIEYIIEQIAEIKKIDPINANIKLNENFERLISREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHN6</accession>
    <name>A0A174EHN6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cueR_1</name>
        <name evidence="3" type="ORF">ERS852471_01452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265142.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37201">
        <property type="protein sequence ID" value="CUO37201"/>
        <property type="gene ID" value="ERS852471_01452"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO37201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="36698" checksum="4D8B4B1E34D5CD15" modified="2016-09-07" version="1">MLINEVCKLTGLTKKAIEYYEKQGLIKPIKSDNGYRNYSQEDIALLNEISLYRKLDISIKDIKVIIKSRDKKDIINNIIKDKQNKEIQIKMQKRYLEEIIENNFDRISIKQLNDEIIESEKNNGEFIKRELIRAFPDGMGKYLAYHFAPYLNEPIDTPDKYEAWINIVEFLDNVPEIKIPRFIQIGYENISDEIAKKINDDTRNEINNMLNAEGEELEKYKQKLLDNIEKQNDKSLLKVMNPFYKFKKQLNEFFNSSGYYDIFLPNMKILSSEYKEYHDKLTKLNDKLSKELGIKYDENMRVIISKDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EME0</accession>
    <name>A0A174EME0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265150.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37405">
        <property type="protein sequence ID" value="CUO37405"/>
        <property type="gene ID" value="ERS852471_01456"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2209143at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="12996" checksum="365EF85E35FE9A1E" modified="2016-09-07" version="1">MNKYLETIRDKIKTNKRKLIKRASIVVAIIAGLGIAAFATVYSIAKSNINYTVEEAKAIVLQSVQGEIVRVNKRLDLDTFSFEYEFKIKDKNNMLIKADVNSSLGVITDLDSYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F142</accession>
    <name>A0A174F142_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative PilT-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265282.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41915">
        <property type="protein sequence ID" value="CUO41915"/>
        <property type="gene ID" value="ERS852471_01525"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933311at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="15612" checksum="98F9616E936E24A8" modified="2016-09-07" version="1">MIQVFCARRGSGKTKRLIELANNQYLESKGDSVYIDDDCRPMFQLHTGIRFVETNEFRVCDCDSFYGMLCGIISSNYDIENIYIDGLSNIVKCTMKESTELFKKIAGITEKFGINVYINVNVDSTEEVPDCIKEYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3E1</accession>
    <name>A0A174F3E1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265338.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43326">
        <property type="protein sequence ID" value="CUO43326"/>
        <property type="gene ID" value="ERS852471_01554"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="159"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="317" mass="33979" checksum="DF33BBACAF025E68" modified="2016-09-07" version="1">MIYGLASGILWGLDTVLLGVALAMTQFVSTEEAIFLAPFVSTFLHDIFSSIWMSIYMTIKGKLKKTFIAANTKSGRFIMLGALLGGPIGMTGYLLAIKYIGPAYTAIISSLYPAMGALLSYVFLREKMKPISILGLFISISGIIILGYAPGGEVMNLGLGFVFALLCVIGWASEAVVCAYGMKEDEVSPEQSLQIRQLTSAITYGFLIIPIVKGIKFTLGVIQTTETGIILLTALAGTASYVFYYKGIHKIGATKAMSLNITYSAWSIIFGVVLLGNSVDLKSIICCILIMIGSIMAAGDLSEIKGIFSFKKKVGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F5Q2</accession>
    <name>A0A174F5Q2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265368.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44146">
        <property type="protein sequence ID" value="CUO44146"/>
        <property type="gene ID" value="ERS852471_01568"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO44146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="367" mass="41653" checksum="555E32360AACB48C" modified="2016-09-07" version="1">MKVLITGANGFIGKNLVAKLRESNNELILIDRDNSKEDLQEGLLKADFIIHLAGVNRPKDEKEFFEGNSGLTGEIVDFLKANNKKTPIVITSSIQADLDNAYGQSKKLSEEALLNYREETGAKIVIFRLPNVFGKWCRPNYNSAVATFCHNIARGEEVWISDPSRKMTLVYIDDVVRNIIDTMEDKNTQNGYENIDIEHSATLGEIVDLLNSFVESRKNLLVPNMNNEFTKKLYSTYLSYLPEDKFSYPLKMNIDNRGSFTEFLKSGDRGQVSINISKPGITKGNHWHHTKNEKFLVVSGQGVIQFRRIDSEKIIEYKVSGEKLEVIDIPVGYTHNIINTGETDMVTVMWVNEIFTSEKPDTIFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8U3</accession>
    <name>A0A174F8U3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF subfamily RNA polymerase sigma-24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE_2</name>
        <name evidence="4" type="ORF">ERS852471_01589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265408.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45099">
        <property type="protein sequence ID" value="CUO45099"/>
        <property type="gene ID" value="ERS852471_01589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO45099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="424" mass="48626" checksum="ED0371BE57759915" modified="2016-09-07" version="1">MRYEIGFESKELLKAIDDVKNGIDYSFNTIYKITYKKVYFLALSIIKDEDTLHDVVQNVYILIHKNINSLKDNKMFISWINRITYNESIRELQKANKRPISMSDEEISSKLIEEDNPLTKYLDNERSKEIMNDILDLDEKYRTVIILKYFRNYKLKEIGEILGCAEGTVKSRLHNGKILLKKKLSKRYGRVLTASLFGVLATNTLVKTTYASTINLISKNEFLKSGSLKSYFVGGIAAGTIVTSSVIIINEVNELKEPIVIESVQYEKGFSKDDIEVELVFSGRKDLQVISQNNELISLQYLSNNKAVFTVNKNGTYKVVCSRDNNNFEILKEINITNIDKEAPVILNGELNNGKLDIFLEDNLSGIDYKSTIDDLNKYNNINNVEVDESQNKISIYLEEGAYNIKVIDFVGNYTMYNINIEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGN5</accession>
    <name>A0A174FGN5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">minD</name>
        <name evidence="10" type="ORF">ERS852471_01650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265522.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48881">
        <property type="protein sequence ID" value="CUO48881"/>
        <property type="gene ID" value="ERS852471_01650"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO48881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="28880" checksum="1CFDDB16F438C9AF" modified="2016-09-07" version="1">MGVSIVITSGKGGVGKTTTTANLGTALAALGKKVVVVDGDTGLRNLDVLMGLENRIVYTIMDVIENRCRLKQALIKDKRYPNLCLLPTAQTKDKDDISTHDMLNIVNNLKEEFDYVLIDSPAGIEQGFENSVVGADKAIVVVNPEITSVRDADRVIGKLDAKGLEDHAVIVNRLNYEMTKKGDMLDVPDIIETLSVKLLGVVPDDRGITVSTNKGEPIVLDQESKSGQAFRNISKRIMGEEVQLLDLSTESSGFFSAFKKLFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FMW5</accession>
    <name>A0A174FMW5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">secA_2</name>
        <name evidence="14" type="synonym">secA</name>
        <name evidence="20" type="ORF">ERS852471_01691</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265595.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50867">
        <property type="protein sequence ID" value="CUO50867"/>
        <property type="gene ID" value="ERS852471_01691"/>
    </dbReference>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="417"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="786"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CUO50867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="837" mass="94520" checksum="71007C5710581758" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FN24</accession>
    <name>A0A174FN24_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hopD2</name>
        <name evidence="3" type="ORF">ERS852471_01670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265558.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49900">
        <property type="protein sequence ID" value="CUO49900"/>
        <property type="gene ID" value="ERS852471_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021833" evidence="1">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="190"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="34688" checksum="97858EC59331BAE7" modified="2016-09-07" version="1">MNSKFLKKLSILSTILISSSALIGAFPKADSNSYIFKKNKDVIILDSDLKTPLPNRFRDVTLLNISGSAQFTKDQVEPLKKAINKENICIVDLRQESHGLLNDLAISYHNFYKLINNGFDSVETIEKENSELNKIKTNSQVNIFHENGKLYKCLEAESVCTEEKAITDCGMQYKRFAVRDGGVPTPDTVDEFVDFIKNKPDDLHLHFHCHAGEGRTTTFMVLYQIMNNQNNLTLDQILSYQYNIGGVVLTNDGYRLGFLDSFYEYIQENKDSNYATPYSQWIVKDMIIKKETENRLFFNYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLN5</accession>
    <name>A0A174GLN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetrahydrodipicolinate succinyltransferase domain-containing protein</fullName>
            <ecNumber evidence="8">2.3.1.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapH_2</name>
        <name evidence="8" type="ORF">ERS852471_01897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.89" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265971.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61355">
        <property type="protein sequence ID" value="CUO61355"/>
        <property type="gene ID" value="ERS852471_01897"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752123at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047200">
        <property type="term" value="F:tetrahydrodipicolinate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019873">
        <property type="entry name" value="DapH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013710">
        <property type="entry name" value="DapH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08503">
        <property type="entry name" value="DapH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03532">
        <property type="entry name" value="DapD_Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DapH_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO61355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="25513" checksum="CCB678E494A2D1C9" modified="2016-09-07" version="1">MSYNFNDHDEIVKYIKNIKKSTPIKAYINGSLNDINDKNIEWYGSNNFYILFGEFEYISKFIIDNKENINYYRLEADRKNSAIPLLDIISINARIEPGAIIREGVKIGKSSIIMMGAIINIGAEIGDYTMVDMNAVIGARGKIGKRVHIGAGAIIAGVLEPPSQEPCIIDDDVLIGANAVILEGIKIGQGSVVAAGSVVTKNVPSGVVVAGTPAKIIKNVDAKTKSKTKFIDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQG0</accession>
    <name>A0A174GQG0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">sfsA</name>
        <name evidence="4" type="ORF">ERS852471_01924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266022.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63256">
        <property type="protein sequence ID" value="CUO63256"/>
        <property type="gene ID" value="ERS852471_01924"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1375946at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="3">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="2">
        <location>
            <begin position="82"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO63256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="26323" checksum="31B2EB1901EC9F62" modified="2016-09-07" version="1">MNYNKRILRAEFINRPNRFHANVIVNGEEIKVHVPNTGRCREILVPGCTVYLREENNPTRKTPYDLIAAIKGDKLISIDSHIPNKVVEEALNNRKIEKLEEYTNVLREKTFGKSRFDFKISKDNGEEYFLEVKGVTLEDEGYCRFPDAPTERGARHLLELVEAKKQGYGAGVMFLIQIEDVEKFSPNDERDPKFGEALRFAASNGVDIFAYSCIVTEDGIEINKPIEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRH2</accession>
    <name>A0A174GRH2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmuC_4</name>
        <name evidence="11" type="ORF">ERS852471_01933</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266039.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63616">
        <property type="protein sequence ID" value="CUO63616"/>
        <property type="gene ID" value="ERS852471_01933"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="8"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO63616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="436" mass="46207" checksum="77F61C529EC78B72" modified="2016-09-07" version="1">MEKFTAFMDKYILPYATKLGAQRHLVAVRDAFIAMIPLTIIGSFATLINNMPFKALSNFLAENTFGQQIKTINGDIWWGTLAIMALLLVIGVAYNLAKSYEENGLQAAMIATAIFFFLAPQVASITPEGATEAVVGWGFMQISYLGTTALFTAIIVGLLATELFVKLGKVKALVIKMPDAVPPAVSRSFAKLIPGMLTVLIFAVIGLIVRTVADGAFLTDLINKYVGIPLSGVTDSLGGAIAITLFIHGLWFVGLHGSNIALPITSTLLTKLGADNAQIMATGSSEPLHTLAGPFFDAFVHMGGAGLIIGLLVAIAIAGRSRKDMLALGTAPAIFNINEPVIFGLPIVLNPIYGIPFIIAPVVTTIVSYLSIKSGLVSPVIVASMPWTTPPIISGFLATGHISGAILALVNIIISIVIYLPFVYAAERMEAKKYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXH3</accession>
    <name>A0A174GXH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidA_2</name>
        <name evidence="1" type="ORF">ERS852471_01991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266143.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65927">
        <property type="protein sequence ID" value="CUO65927"/>
        <property type="gene ID" value="ERS852471_01991"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="30455" checksum="837BC3E130952662" modified="2016-09-07" version="1">MRILLASDLDKTLIFDNKISEENKDAIRRFKEAGGVFAISTGRPYNGVEKVIEELRVEPDYLILNNGALIITGGEEIVHREFIPFNVVKNIFNDMDNDEVVISVETGFRTYPIDLKSKGAEAAFISDIDSTFKNLELIDKLDEVSEEDKEKIAAISLFLPRVDINEVQTACDYVNDNYGNYVIAYRNTRFIDIVPAGCSKGSGVKWVSDEENIDIKDVYVIGDSWNDDSMFEITDKSFTFTYAEEELKEKTNYIVETVAECIDKYILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYI2</accession>
    <name>A0A174GYI2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HPr kinase/phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266128.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65555">
        <property type="protein sequence ID" value="CUO65555"/>
        <property type="gene ID" value="ERS852471_01982"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1794568at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="304" mass="34507" checksum="39FFBE694CB8D5AF" modified="2016-09-07" version="1">MYNYIVYGLKIKSDIEIKEFMKNEDENNDINIVLGQTSQDIKDMICEGIRSFYSKTKIWFHIDNIATYYITDGKTILVEPCENPDETLLRVYLMCSCLGFIMLQREQVAIHGGVINIDGNAVIFTGDRGAGKSTLTTALRNKGYQFISDDVAATYFDKVPYVYPGFPYQKLCDDAMDSLGYKREGLSTINGEDKVKYVVPAFDSFYDKSAPLTSIVKLEVGDVDKVTIDKVIGQEKLILIMKNVYRQEFLGFMGGMTPVFIKKCIDIAKNITCYKVTRPKEGFTVNEQINLIEDTFINIEEKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZD8</accession>
    <name>A0A174GZD8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ribose pyranase</fullName>
            <ecNumber evidence="2">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fucU</name>
        <name evidence="4" type="ORF">ERS852471_01998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266157.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66200">
        <property type="protein sequence ID" value="CUO66200"/>
        <property type="gene ID" value="ERS852471_01998"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1750843at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO66200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="141" mass="15630" checksum="0DB764456F211A36" modified="2016-09-07" version="1">MLKGIPSILSPELLKILMEMGHGDTIVIADGNFPSNTCGQRVVRLDGHNVPEILEAILKLFPLDTYSEKPVSLMSVVPGDDVVPTIWDTYETIINNNFDKFTSFGFLPRFDFYEKAKEAYAVVATSEKALYANVILTKGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5W5</accession>
    <name>A0A174H5W5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/aminoacyl-tRNA ligase-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266262.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68766">
        <property type="protein sequence ID" value="CUO68766"/>
        <property type="gene ID" value="ERS852471_02049"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="158" mass="17698" checksum="5C7754098B9094A1" modified="2016-09-07" version="1">MAIEKVREYFKKYGIEDKIQEFDVSSATVELAAKALHCEPKRIAKTLSFIVNDSVILIVVAGDAKIDNKKYKQKFSTKAKMIPVEEVVELVGHGVGGVCPFAINEGINVYLDESLKRFNTVFPACGSSNSAIELTIPEIEKYSNYDSWVDVCKEWNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRV3</accession>
    <name>A0A174HRV3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin hydrogenase</fullName>
            <ecNumber evidence="6">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.7.2" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266580.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76067">
        <property type="protein sequence ID" value="CUO76067"/>
        <property type="gene ID" value="ERS852471_02233"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027631">
        <property type="entry name" value="FeFe_hydrog_B1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04105">
        <property type="entry name" value="FeFe_hydrog_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="496" mass="54822" checksum="F9CB6BA8DE50E894" modified="2016-09-07" version="1">MFQFETQLKKLKHEVLTEVAKLAKKNEISLESIEKVPYEVIKGDKAQYRCCVYKERAIVLERAKLAAGYLANGDNFDTELIDIRPDEQIIYIIEAACDRCPIDKFNVTDSCRNCLAHRCKEACNFGAINIVAGRAYINQELCKECGMCKRECPYDAISEVMRPCKKSCPTGALDINEEDRRAIIKEEICVNCGSCMRSCPFGAISDKSLIVPVAKRLGRHRKMYAVVAPAITGQFGPTMNYGKIRNAFKALGFEDMVEAALGADAVTVHESNEFVERMERGDKYMTNSCCPGFLSFIEKTNPSEKDRISKTVSPMVATARYIKSKEPDAKVVFIGPCTAKKGEAVRLGVSEAVDYVLTFEELLALFEAFDVNPFDMEDENVNDASVFGRGFGMAGGLTAAIQNYVSDSGCKAEFKPVQVSGLDCKKTMNLAKMGKLQGNFIEGMMCEGGCINGAGTIVPPLRARGAFTKINNRTTIKAVLKNSTLSEFEDINLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTG4</accession>
    <name>A0A174HTG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Voltage-gated chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clcA</name>
        <name evidence="6" type="ORF">ERS852471_02257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76876">
        <property type="protein sequence ID" value="CUO76876"/>
        <property type="gene ID" value="ERS852471_02257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO76876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="393" mass="42392" checksum="D616FBC51A67503E" modified="2016-09-07" version="1">MRLVKILRLTFVAIVIGLLSGVSIGVFLILLEKSINLNLTYYNLIWFLPVSGSLMTFLYKKFGGNSNKGNNIIIENINGSNEEIKFIMAPLVFIGTVLTHLFGGSVGREGTGVQIGGTIANSLCKLLNYKEDKKILLITGMAAGFSSVFGTPLAGTIFALEVSAIGSISYNSMLPAITAAIVGDRVVRFLGVKHTHFDFPPVEPFLFTNIFRVIVMSICFGLVSRLFIEMTKLFKYILGKYIKNNYLKAFIGGSLMVSVTLIIGNRVYNNLSLGLLTGAFDKEVPYFAFLIKLVLTTLCLGAGYQGGEVTPLFVIGATLGSTLANIFGVPRAVAASLGLVSVFAGATNAPIACFIMYIELFGSVNIVFAMVVCIISVIISGKKGIYSSQLWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4V4</accession>
    <name>A0A174I4V4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication protein DnaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaD</name>
        <name evidence="2" type="ORF">ERS852471_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266754.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80085">
        <property type="protein sequence ID" value="CUO80085"/>
        <property type="gene ID" value="ERS852471_02335"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1996763at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017019">
        <property type="entry name" value="DNA_replication_prd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033722">
        <property type="entry name" value="DnaD_CA_C3587_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="1">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DnaB_2" evidence="1">
        <location>
            <begin position="224"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO80085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="331" mass="38577" checksum="6398FD2C557B6501" modified="2016-09-07" version="1">MSTFMLKNKQLDFTPVSNIFIEKYMPKARGEFIKVYLLMLKYNTCGEMGVTSSILATSLNLLESDVLNALNYWNDEGLIKLIPIDKMGNFNIEFVDLVKESKSQSKEINLLQALNKNSTKDMLNDIERLLGRPLSPKEMTTYLSWQDDFNFSSELILILFEYCVSRGKSDYRYIEKVAMAWKDMNITTVEEAQNYIKKNEDKWIKIRHILNYLGIKNPELMKPQEEMLDKWINDFNFPLDVIEKACNICFQRLNRADFKYIDGILSNWNKNNLKTIAAIEEKDSKPSGITPSKGNYTSNNSKRFIGQNINNKSSKDYDDLEKELLGWYNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I8U7</accession>
    <name>A0A174I8U7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly(3-hydroxybutyrate) depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82891">
        <property type="protein sequence ID" value="CUO82891"/>
        <property type="gene ID" value="ERS852471_02402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024042" evidence="2">
        <location>
            <begin position="28"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="594" mass="66657" checksum="1AA89F38D653AFA5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IAT5</accession>
    <name>A0A174IAT5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266891.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83551">
        <property type="protein sequence ID" value="CUO83551"/>
        <property type="gene ID" value="ERS852471_02417"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1318562at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO83551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="27203" checksum="07B1EB8DE5E5EF30" modified="2016-09-07" version="1">MLYLVYILAGIVAGVVTGLAGLSAAVVITPLLVSVCGWQSYDAVTVALSADVLASLLTAYTYYKNRNIDLKNGMLVTITAFIGSIIGSYSGYLFSQSQPDGLGYISMATTIFLGIKFLVKPIEKGHDAKSGINQISKKKILQAMFLGCAIGWICGFTGSGGGILMLTVFTLLLGYNLKVAVGTSTMIMTLIALTGAISHISMGAILQPIPMLLVTIFCLIGAYVSAKFANKCEIKKLNRIVGTCLGILGIVTILIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IEG3</accession>
    <name>A0A174IEG3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_12</name>
        <name evidence="2" type="ORF">ERS852471_02423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266904.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83748">
        <property type="protein sequence ID" value="CUO83748"/>
        <property type="gene ID" value="ERS852471_02423"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="457" mass="49534" checksum="8C3CA25831C0CB98" modified="2016-09-07" version="1">MTNEKISLTEGNAKVGMLKFAFPIFLGQVCQQLYNVVDAIVVGNYVGQNALAAVTSTGALIFLLVGFFGGMFSGAGVIISRYFGAKDEKKIKKAVGTAVSFGLISGTILTIIGTLLTPTILRLMGTPDNVFQDSSIYIRTYFTGIIFVVMYNTACGIFQAVGDSKRPLYYLVISAIINVILDIVFVGFFNMGVIGAAIATVISQGTSAFLAFFRLARIDSTYKVTIKGICIEKSILKSMINIGLPSGIQNSVIAFANVVVQSSVNSFGAVVMAGNGAYIKLEGFAFIPVTAFSMAITTFVSQNIGAKNFDRVKEGARFGILFSCICAEVIGLVIFVLAPYLISIFGNNPDVIAVGAQRAHLNALFYFLLSFSHCVSGVLRGAGRSKIPMLTMLICWCVIRVSYIQIATHLINDIAVVFWAYPITWFLSTTVFLIYYKKSNWLEECKKKALSIEIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFG1</accession>
    <name>A0A174IFG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266900.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83669">
        <property type="protein sequence ID" value="CUO83669"/>
        <property type="gene ID" value="ERS852471_02421"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1339744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO83669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="23250" checksum="980727C4DA98C457" modified="2016-09-07" version="1">MELSINEINELSAVELLERAYGKKLESKKTVLEYIEIVKFLRDPEVNPEKVQETYNLIYNSIDKMNDSVKPNTIMFLMNALKAQLGKFVSDKDPKKEHGFIKYFKLAYPAKMRGKGFTRVLMNINNITDEQIWTTITYINRGYIKREIYLTGDDKIAIKEMVGKLVAKNNIKYVNQVKSMEKLLSALGIKVINVDGKFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174INF3</accession>
    <name>A0A174INF3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ORF">ERS852471_02520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267064.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87961">
        <property type="protein sequence ID" value="CUO87961"/>
        <property type="gene ID" value="ERS852471_02520"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="23662" checksum="05D81CA806A48E39" modified="2016-09-07" version="1">MARYTGATCRLCRREGQKLFLKGDRCYTDKCAFVRRSYAPGQHGAAKKKMSNYGVQLREKQKARRIYGVLESQFRTYYEKADHMKGITGENLLKLLEMRLDNVVYRLGYGASRNEARQLVTHGHFLVNGKKVDIPSYRVSVNDVIAVCEKSRGTEKFKTFVENPKTLPKWLEANVENYEGKVVAEPAREDIDVPVNETLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IPW0</accession>
    <name>A0A174IPW0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplW</name>
        <name evidence="10" type="ORF">ERS852471_02495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117026.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86920">
        <property type="protein sequence ID" value="CUO86920"/>
        <property type="gene ID" value="ERS852471_02495"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO86920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="98" mass="11182" checksum="62257B4738CCD7EC" modified="2016-09-07" version="1">MKLTSHDIIRKPVITEKSMTAMAEKKYTFIVHMNANKVQIKRACEEIFGVKVEKVQTIRTMGKTKRMGVHVGKRADQKKAIVTLAQDSKAIEFFEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ISY0</accession>
    <name>A0A174ISY0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">feuB_1</name>
        <name evidence="8" type="ORF">ERS852471_02570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267155.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90522">
        <property type="protein sequence ID" value="CUO90522"/>
        <property type="gene ID" value="ERS852471_02570"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO90522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="317" mass="34766" checksum="FAE127475390DA4F" modified="2016-09-07" version="1">MKKRYLFLILIVLSIASIFIGVSSISIKDIFELNIDKLEVIFISRLPRLIAIIVAGVGLSISGLIMQQISKNKFVSPTTAATVDFAKLGILFSMVVLTSATTMQKMITAFIFAVVGTMIFMKMIKAIKLKNIIFVPLVGMMLGKVVGSITTFISLKYDLVQNVTSWMEGDMSLIMKGGYELIYLSIPMVILAFLYANKFTIVGMGEEFSINLGLNYNFVVNVGLVIVALISAVTIITVGNIPFLGLIIPNIVSLYSGDNLKKTLYHTALLGPVFLLICDILGRIIIFPFEISIGMMVGVIGSAIFLYMIIRGTKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IU31</accession>
    <name>A0A174IU31_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF218 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydcF</name>
        <name evidence="2" type="ORF">ERS852471_02580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90883">
        <property type="protein sequence ID" value="CUO90883"/>
        <property type="gene ID" value="ERS852471_02580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="64"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="31868" checksum="374456D2014378CC" modified="2016-09-07" version="1">MNINFRYSKDNHISNIHCSKINTSESFNLSSYINSLGEFLATRDIDNLSVESLYNKYSILNVDILVLLGNAIPYTIGVAYEAYKKGLCNKILVSGGIGHSTHFLISAIQTNFKFNDVKIDNNSEADIFKDILVNYYNVPEKDIIVENQSTNCGDNALKSVQLLDKLKISYNSILLIQDPTMQLRSYASFAKYLEDKDVKIINYAPFIPTLDNNMLFINKDIDGIWDIDRYLNLIVGEIPRLKDNEKGYGPNGKNFIVHVDIPDYITDNYNKITSFIDNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J0F2</accession>
    <name>A0A174J0F2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267263.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93203">
        <property type="protein sequence ID" value="CUO93203"/>
        <property type="gene ID" value="ERS852471_02633"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1218480at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043831">
        <property type="entry name" value="DUF5808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19124">
        <property type="entry name" value="DUF5808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5808" evidence="3">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO93203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="379" mass="44327" checksum="959C7E1B4046656C" modified="2016-09-07" version="1">MEELVKYFIFPFITIILYIQVFNLNRFSNNGIYFGIRVPLEYKDDKDILELEKIYKKQNIILILPIIILVNIIYFLNMKMWLFLTYIFILIGIINILPIIYWIKMRNLKNKKGWKVLSKNVVIVETGLRQPQKNSRVKAVDTRYYLILLIIPLIISILTLINYNIIPQLIPVHYNVSGVVDKVVEKGTIAAYMNLAGIPFMLVLMIFFFMFINNITVKSKSDLFSGKIKETIEKKLLFKKYVSIFTWILALETLIIMAIPQICIIFNLSIEIMTIPMIILFISIVIFLVMSYYLGQGGRNIKTNEEGEENYRDDDDKYILGALYYNKKDPALMVEKRIGVGWTVNLAHPLGKIVMILPFIIIVGMIIFMYFYEKTNPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J0I6</accession>
    <name>A0A174J0I6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of Mn/Zn ABC-type transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">znuC</name>
        <name evidence="5" type="ORF">ERS852471_02604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267211.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91776">
        <property type="protein sequence ID" value="CUO91776"/>
        <property type="gene ID" value="ERS852471_02604"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO91776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="28858" checksum="D9E04015F8EA3C09" modified="2016-09-07" version="1">MENSNYTNNNKCSDFCCTKVENLSVTIGTNEILKNINLHFHCGELTSIIGPNGAGKSTLFKALLGEIKHTGKLTYVGTSSKGVSSPIIGYVPQYLNFDLSTPASVLDLFIACNSKVPVWLYSSKKYREKVSESLSRVKAEYLIDRKLGALSGGELQRVLLALALDPMPNILLLDEPVSGIDQNGLELFYDILMDVKSKYDLSIILVSHDLDLVAKYADKVVLLKGSVLCSGTPKEVFTNKTTSKIFGLSWYEEDDSKSKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J1A3</accession>
    <name>A0A174J1A3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dut</name>
        <name evidence="5" type="ORF">ERS852471_02592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267192.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91368">
        <property type="protein sequence ID" value="CUO91368"/>
        <property type="gene ID" value="ERS852471_02592"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO91368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="17445" checksum="DA382BE815607BD9" modified="2016-09-07" version="1">MKMKIKYFEGATKLQKISKGNWIDVYANKDMFVPLNERAMIPLGFALELPQGWEGHLAPRSSTFKTWGIIQTNGVGVVDDTYIGDNDQWHMPVFCLQYKSIEIIDGIEEKGTWIKKGDKVGQFRIMEVMPEIEFEEVESFGNADRGGFGSTGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J4L0</accession>
    <name>A0A174J4L0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267329.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94674">
        <property type="protein sequence ID" value="CUO94674"/>
        <property type="gene ID" value="ERS852471_02668"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025288">
        <property type="entry name" value="DUF4080"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13311">
        <property type="entry name" value="DUF4080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="169"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO94674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="555" mass="66131" checksum="99B5CBB155ECC711" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J5G5</accession>
    <name>A0A174J5G5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="7">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ntpA</name>
        <name evidence="7" type="synonym">atpA</name>
        <name evidence="11" type="ORF">ERS852471_02675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94984">
        <property type="protein sequence ID" value="CUO94984"/>
        <property type="gene ID" value="ERS852471_02675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="10">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="8">
        <location>
            <begin position="213"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="233"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO94984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="592" mass="65357" checksum="0DAFC863C46002EA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J751</accession>
    <name>A0A174J751_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluC</name>
        <name evidence="5" type="ORF">ERS852471_02655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267303.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94116">
        <property type="protein sequence ID" value="CUO94116"/>
        <property type="gene ID" value="ERS852471_02655"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO94116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="36924" checksum="4119FF6DED0557E3" modified="2016-09-07" version="1">MKIEIGANEAGQRLDKFLRKYLKDVPLSAIFKAMRKGDIRVNGSKKKENYKLELDDVIEIRYIQSKKEKKDDSFIKVNAGSLMITYEDDNIVVVEKWPGVLVHPDQKGAEPSLTDYVLSYLNGKGDYIPEKEITFTPAPCNRLDRNTSGVVIFGKNFEALRGVNEMIREGKVKKYYQALVKGRIKDGLYKGYISKDENENISKVYDKQVPNTKEISMEVKTLQSNGAFSLLEIDLITGRSHQIRAHLSHLGNPIIGDFKYGDKKINSYFDNKFGLNYQFLYAYKLIFRGGEGKLEYLKNKTIVEALPPMFKKVKNEVFKFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J8E0</accession>
    <name>A0A174J8E0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron hydrogenase 1</fullName>
            <ecNumber evidence="9">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.7.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267323.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94556">
        <property type="protein sequence ID" value="CUO94556"/>
        <property type="gene ID" value="ERS852471_02665"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO94556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="579" mass="64589" checksum="C6E518CF1CA906EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDP3</accession>
    <name>A0A174JDP3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95229">
        <property type="protein sequence ID" value="CUO95229"/>
        <property type="gene ID" value="ERS852471_02681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO95229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="49" mass="5640" checksum="C67C847F418431F0" modified="2016-09-07" version="1">MTKNNLKNTSIPISQIGNFTKHAVESFEENIVNQHNYLEKVHNNLSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPF6</accession>
    <name>A0A174JPF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine ABC transporter spermidine /putrescine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">potD_1</name>
        <name evidence="3" type="ORF">ERS852471_02773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267514.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99697">
        <property type="protein sequence ID" value="CUO99697"/>
        <property type="gene ID" value="ERS852471_02773"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025332" evidence="2">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO99697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="353" mass="39530" checksum="787B8D07ADDF0E0F" modified="2016-09-07" version="1">MKKIKKLSALAAATVLTASLFTGCGNSNVGENGTINFFNVGDYIDEALIQKFQKETGIKVNYDTYDTNEIMYQKVKTNPGTYDLVVPSDYMVQKMINEGLAEKIDFNNIPNYQYINPEFKDLSYDPNNEYSVPYMWGTVGILYDTTRVTDPVTSWDILWDSKYNDEIYMFNSLRDALAVAFLKDGYSINTTDPSQIEDAKKALIEQLSLTNPIYVNDEVKDNMISGEKALATVWSGDAIYCMASNPDLAYAIPEEGSNKWVDALVIPKDAPNKAGAEAFINFLCDPQNAKENVDYIGYSTPNKAAFDLLDDETKNNPAAYPSDEVLDKCVLFVDLDKSTLKLYEDAFTEVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPN6</accession>
    <name>A0A174JPN6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267596.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01754">
        <property type="protein sequence ID" value="CUP01754"/>
        <property type="gene ID" value="ERS852471_02812"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP01754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="23002" checksum="44D16C70670B5481" modified="2016-09-07" version="1">MNNKKEDVHEALLESFKNLILNYDFDKITIKMITDEAGFIRPTFYNHFADKYEVLEQICYEDIFKGSEMLINNKMPYEAIHYMFSRIENNKEFYLKAIKVTGQNSFEEIISGNLNKIFKELFNQYGNSKNGYEEQFSLDDIAEYYSRGLTFIIKRWIEDGLKVSAKTLTKQYEILVTNSLDDIIHERINCMNGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JUE1</accession>
    <name>A0A174JUE1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267657.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03382">
        <property type="protein sequence ID" value="CUP03382"/>
        <property type="gene ID" value="ERS852471_02846"/>
    </dbReference>
    <dbReference type="OrthoDB" id="710313at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09024">
        <property type="entry name" value="Aldose_epim_lacX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037481">
        <property type="entry name" value="LacX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP03382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="33642" checksum="3CC2B244F240D60F" modified="2016-09-07" version="1">MLQVIENDFLKISSSIHGGELHSIQSKKTNTEYLWNGNPDFWKYHAPILFPIVGKVKDGKYKVDGKTYELPQHGLARVKDFSIKNSEGNKITYELIYSEDTLKVYPYKFSLCISYELIDNNLKVSYKVTNLDNKTIYFSIGAHPGFMCPLKDNETLNDYYFEFNKKETAELMTLDMNVGLISHNTIPYLNDENIIPLHKELFKNDALIFKNLDSNLISIKSKNHNQVLSMDFTGFPYMGLWAMPTGCPFVCIEPWFGHADFVDFDGELKDKAGIQSLEIGKEFNCSYSIIVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JXI7</accession>
    <name>A0A174JXI7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YihY family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03331">
        <property type="protein sequence ID" value="CUP03331"/>
        <property type="gene ID" value="ERS852471_02845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP03331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="30245" checksum="8877AA5C061E76DD" modified="2016-09-07" version="1">MIYFIIKIKNDDIFALGAQLAYYLILSFFPFLIFLMTIIGFSKLDSMQIIEGLSAILPSSVFELTSSIVVEVVENQYTGLLGVSIVLSMWAASSAFRAVTKGINKAYNLKENRSFIKRVIIALICTFALAFTIVVALVLLVFGNLIGNLLISYIPYNALIGKLWNLLRYIMVLIIMICIFAGIYRYTPAKRISWREAFPGAIVSTIGWLIVSLCFSFYINNFSNYSRLYGSLGAVFVLMTWLYISSIILILGGEINSVLVIRKNNLRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JYW8</accession>
    <name>A0A174JYW8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF subfamily RNA polymerase sigma-24 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigV</name>
        <name evidence="8" type="ORF">ERS852471_02879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267719.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04974">
        <property type="protein sequence ID" value="CUP04974"/>
        <property type="gene ID" value="ERS852471_02879"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP04974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="170" mass="19931" checksum="A3F0E621E78E5BF3" modified="2016-09-07" version="1">MVNELLFKKAVEGDMESFVKLIEPIKENLYKVSFMYLKNENDALDCIHEAIIKAIKSLKNLKEPQYFNTWITRITINVCKDYIKKNSKVTLVNINDYENNLIIENTKSDFEEDIAIALDKLSPKERELIVMRYLEDKSLKDISHKTNVPLGTVKSRLNRTLKKLKIYMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7H5</accession>
    <name>A0A174K7H5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP06771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267791.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06771">
        <property type="protein sequence ID" value="CUP06771"/>
        <property type="gene ID" value="ERS852471_02920"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP06771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="17975" checksum="89B7AA92949A7D84" modified="2016-09-07" version="1">MRIRIEVDDRIEENEVIVRCSELNDEVKNIQKVLGEVLSQSKQIIFYKGNTEYYISLDEILFFETEESSISAHTINDVYSVKYKLYELEEILPNNFLRVSKSTILNTNHIYSITRNITSASIVEFQNTHKKVFVSRHYYKVLQFKLLEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8J4</accession>
    <name>A0A174K8J4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glxK</name>
        <name evidence="5" type="ORF">ERS852471_02958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267856.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08372">
        <property type="protein sequence ID" value="CUP08372"/>
        <property type="gene ID" value="ERS852471_02958"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1292731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP08372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="381" mass="40268" checksum="0EC7015FFD771C09" modified="2016-09-07" version="1">MKKDFVIVLAPDSFKESMTAKEACVAMERGIKKVNSDIKCVHVPMADGGEGTMQSLVDSTNGKVYSLEVVGPLGNKVKAEYGILGDRDIGILEMASASGIQLVPLDKRNPLITTTYGTGELIKACLDKGVKKLLIGIGGSATNDGGAGVIQALGGRLLDKYGNELGFGGGELGKLHSIDLTNFDSRLNDITVEVACDVNNPLCGERGASNVFGPQKGATEEMISLLDDNLRHYADIIKNQFGKDILNVPGAGAAGGLGAGLMAFLDGNLKKGIEMVIEYAGLEEKVKAADMVWTGEGSIDFQTQYGKTPLGVATVAKKYNKPVIAFAGKVGDNIDVLYEKGIDCIFGIMQGVMSIEEALAKGQENLEKAAENVIRLMKLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KIY6</accession>
    <name>A0A174KIY6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267912.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09768">
        <property type="protein sequence ID" value="CUP09768"/>
        <property type="gene ID" value="ERS852471_02982"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919328at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP09768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="12676" checksum="9FFAD9CFD79C174F" modified="2016-09-07" version="1">MGVWGLDIYDDDLAVDIKEEFERYLMEGMDEAEAIDELIASNDNLLDDPQDVGTFVLTVATLARDNDVTSKKVTKMLKALHRNSEYWNDLKENEEELYEARKDLLREFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KUZ6</accession>
    <name>A0A174KUZ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper-sensitive operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csoR_4</name>
        <name evidence="1" type="ORF">ERS852471_03110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268153.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15863">
        <property type="protein sequence ID" value="CUP15863"/>
        <property type="gene ID" value="ERS852471_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP15863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="89" mass="10056" checksum="21F55919FD9133F3" modified="2016-09-07" version="1">MDSNDKLNKDIINRLKRIEGQVKGIQGMVEKNVCCDDILIQVSAVRSAINKVGGLLIESYANNCLQLDEESKEYESIKKLIKNINTFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KW37</accession>
    <name>A0A174KW37_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein predicted to be involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268079.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13695">
        <property type="protein sequence ID" value="CUP13695"/>
        <property type="gene ID" value="ERS852471_03069"/>
    </dbReference>
    <dbReference type="OrthoDB" id="598606at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="325" mass="36731" checksum="99693FA5D2DAE86B" modified="2016-09-07" version="1">MNKRVYGVIGISSKMANWNADFTGYPKTTSNGEVFGSDKALKYPMKKMWDENGEKVLYIKSMKLSQKEDKKKGTVESILVPRTLKERYEQIFSVEDLKKTKDTAEVLKNLFNSIDVKNFGATFAEEGNNISITGAVQIGQGLNKYEDTAADEQQILSPFRDGKDLEKKQKKDEDAEEAKNSTLGTKIVSTEAHYFYPFSINPLAYKEYKELGVTEGYTEDDYKKFKNAALVSATSYATNAKIGCENEFALFVETEQDLYLPNLSQYINFEKGVDKDVIEIKCGELLGKLGNKIKSIEVYYNPYTTEIESDIEGAKLLDIFTQTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L531</accession>
    <name>A0A174L531_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268218.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17961">
        <property type="protein sequence ID" value="CUP17961"/>
        <property type="gene ID" value="ERS852471_03146"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2188340at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="59" mass="7270" checksum="A78A082985DEB50B" modified="2016-09-07" version="1">MREMTWDEYYAGFYDWSLSTQKSYSYRLSDFGDSEEVFEIVNEFAFYDSKFATRFVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L933</accession>
    <name>A0A174L933_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoR_14</name>
        <name evidence="11" type="ORF">ERS852471_03204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21074">
        <property type="protein sequence ID" value="CUP21074"/>
        <property type="gene ID" value="ERS852471_03204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="289"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP21074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="501" mass="58264" checksum="6C1A9B73CB214D22" modified="2016-09-07" version="1">MFLKNKWNNLSIKKKNFIWSVLIIIISFTLLYGGIYLFMPKVYENYKLNKIYSSIEELKTTLEETEDLDLSVTLDKFSYDNNLDLILVKKDKENRIVSIVYSSFREWINDPGKIPFLKEEELPPHILKRFKLSQDEVNEAVYKPINKKGSLNIENDITIRSLKGKYSLIVHVAVSPIDEAATIVALFFPFAIITIIVIAIAISTFYSIQISKPLIKINDVAKKMSNLDFDNVIEIKGDDEIGQLSKSLNLMNENLKNSFKELEHVNSKLTEEIELERKIEKQRREFIATISHELKSPITIISGQIEGMIYKIGKYKDRDKYLKESYDVVQKMRELVQELLDMSRREDQKLKCIFVNMNLSMLVEDILNDLYYFCEDKNITLEKHIEESVYINGDINLLTRAITNIIKNSIVHSPINEKVIISLNKKELAVQNTGVNIPENEIENIFEAFYRVDKSRNRKTGGTGLGLYIVKSILDQHKNIKYSIYNKDNSVVFYMRFDDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LCF1</accession>
    <name>A0A174LCF1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor G</fullName>
            <shortName evidence="7">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fusA_2</name>
        <name evidence="7" type="synonym">fusA</name>
        <name evidence="9" type="ORF">ERS852471_03223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268348.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22104">
        <property type="protein sequence ID" value="CUP22104"/>
        <property type="gene ID" value="ERS852471_03223"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
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        <property type="entry name" value="EFG_II"/>
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        <property type="entry name" value="EFG_III"/>
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    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
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        <property type="entry name" value="EFG_V"/>
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    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
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    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
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    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
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    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
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        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
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        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP22104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="688" mass="75745" checksum="50AD93C34C0F27D2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LCR5</accession>
    <name>A0A174LCR5_9CLOT</name>
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        <submittedName>
            <fullName evidence="4">TQXA domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">ERS852471_03192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
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            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268289.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20317">
        <property type="protein sequence ID" value="CUP20317"/>
        <property type="gene ID" value="ERS852471_03192"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1641909at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
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        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026867" evidence="2">
        <location>
            <begin position="30"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="3">
        <location>
            <begin position="74"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP20317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="27772" checksum="7669CB744CAE6BAB" modified="2016-09-07" version="1">MKAFKSFQFKVIILVLAFVLLSTTVRGFALTNENYSVAPEGLFVNTEDNIIGKFYYDDFVVNVQKIVSAAGLGYCLDLDKDYHTGEKFKSDGPANGDINIILSNGYPNRSVEELGVNDEDEAYLATQVALWTLFEGYNVKKIDTGNAEVNADARNIYNNVINNKRYELENDTILYRTNDSNIQGIVIYVKQPIEIKPIPPTELVPPVVVPPEEVIPPTSDEKPTVDNNNNTTDEGTAGVSDNIQNDAPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LN51</accession>
    <name>A0A174LN51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adaA_2</name>
        <name evidence="5" type="ORF">ERS852471_03245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP23140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268389.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23140">
        <property type="protein sequence ID" value="CUP23140"/>
        <property type="gene ID" value="ERS852471_03245"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP23140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="295" mass="34036" checksum="76DF87D1921F3F41" modified="2016-09-07" version="1">MGNTRYLLTKNNVYDLDFELIYISKSKFENDWHSTLHMHPFTEIFFITSGQGTFQIGDEIVSVKESDLILINPNCSHTERSVSSSNPLEYIVFAINNLAIGISPSTLNEDNSKDALNTYKVLNFNKKKSEILYNLNTLINELEEKNLNYELACKSILTLFLIQVMRNTSSDIFITENFEKVNIECMKIKNYIDSHYSENITLDFLSNLTYVNKFHLVHLFTKEMGISPINYLINKRIDESKNLLITTNYSIRDISSIVGFSNSSYFSQMFKKIAGISPKDFRLNNSKKQTENKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LPL2</accession>
    <name>A0A174LPL2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dus_2</name>
        <name evidence="9" type="ORF">ERS852471_03293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000039">
        <property type="protein sequence ID" value="CUP26132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268466.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26132">
        <property type="protein sequence ID" value="CUP26132"/>
        <property type="gene ID" value="ERS852471_03293"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="8">
        <location>
            <begin position="5"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP26132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="319" mass="36876" checksum="4F5E25D27B78712F" modified="2016-09-07" version="1">MKFYLAPMEGITVHIYRNSFEKYFGGIDKYFTPFIVPNNSKSLKTKELRDLLPENNRGLNIVPQILTNDAEGFITTARKLQQLGYDEINLNLGCPAGTVVGKNRGSGFLALKDDLDRFLDEIYKIDDMKISIKTRLGKNSPDEFYDIINIYNKYPLEELIVHARTRDDFYGNKPNFEVFKHGVDVSKAPICYNGDIFKVEDYDKFVKDFPNVNNIMIGRGLLANPGLVNEIKGMAGVDKKILKEFHDEVFNTYREVFQEDKNAMYRMKEVWGYMIYMFSDNKKYAKKIKKAQKVSDYNHAVESLFAEQEIVNGAGFFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LUG5</accession>
    <name>A0A174LUG5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000041">
        <property type="protein sequence ID" value="CUP26621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268470.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26621">
        <property type="protein sequence ID" value="CUP26621"/>
        <property type="gene ID" value="ERS852471_03298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="39445" checksum="9719D16620E2D9E4" modified="2016-09-07" version="1">MENNIEKGEKLEVKSLRLSPSVDAKIKELAGDYGNVNAFIEYLLTLNEKENNAIKYPDFKANIEAFSVLLSKLDRAYMSVVEVGANAAQFAREEVSKEMESQRQTISDLQEKNKGLSNSLELAKSQLTMAETAKGIAQMENETLTNINKKNDDLIESLKKEIAKLREDLEQQEMFKNENEQLKEEINSMMEDQQALIDHNKSLEIESKELHSAVAGLKTQEEMLKNNIAELNIEMKVYKGTAKELEKEHKLEIKELEKVHKEDIKRLNEEFNAKLEREIERVTTSAAKEVELQNREFKLKEEQLKFNIEKLQEKLNETSIILNATSQELKQIKAKNKQKGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LYI3</accession>
    <name>A0A174LYI3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication initiation protein REP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">repB</name>
        <name evidence="2" type="ORF">ERS852471_03301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gram-positive plasmids replication protein type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000041">
        <property type="protein sequence ID" value="CUP26750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268474.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26750">
        <property type="protein sequence ID" value="CUP26750"/>
        <property type="gene ID" value="ERS852471_03301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000989">
        <property type="entry name" value="Rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01446">
        <property type="entry name" value="Rep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="342" mass="41107" checksum="B6CBBDC9AD439409" modified="2016-09-07" version="1">MDKYKEKRLRSQPFRSLIKPYVSKKSYKLINDCGNFLMFLSDRTLEKKKLNTGEFCKNRFCPMCAWRQARRDALKIAVLMEHLKLEENMQMIFLTLTTPNVTGDNLNDEINHFNKAFKKLMQRREVKRLVQGYIRKLEVTYDSKFFITPDLYKRKKKYYDYRNLGIGDKNPTYDTYNPHFHVCIAVPREYGRKSRTMQFITDNKWLEMWREACDDPSITQVKVQYIKTGRAEECKEMFELAKYTAKDSDYLLSPEVFKVFYEALKGKQLIVYSGLFKEALKLYEAGELDMYKPKDMVEYIYMLHYEWSKSNGGTYKEILKRELTKEEYEKYNKCKIEELNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XE44</accession>
    <name>A0A173XE44_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaF</name>
        <name evidence="2" type="ORF">ERS852471_00003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN48915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262670.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48915">
        <property type="protein sequence ID" value="CUN48915"/>
        <property type="gene ID" value="ERS852471_00003"/>
    </dbReference>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN48915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="31447" checksum="49A3FC9CBAC9809E" modified="2016-09-07" version="1">MTKLLYKTVSNILSKYDFNYSIIFKDLSSSETISWHYNSKGSEILSFPSASTIKIFIAIEAYNQINKGIIFEDDVILIEDNMKVGGSGIISKYSKNLEISIGKLIYLMMTESDNTATNILINILGMDNINVMIKKLSINNSFLNRKMMDFNAIKNGFDNYTCAYDLATVLEQLYKNTCINEHYDNLILSIMTNCRNNSKIPSRLPSKIKIAHKTGELDYIENDAAIVFTPYGDYILTILTEGLDNEKEIKIISEISKIIYDSYIYNKKIFTSSSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XV73</accession>
    <name>A0A173XV73_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262873.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55170">
        <property type="protein sequence ID" value="CUN55170"/>
        <property type="gene ID" value="ERS852471_00123"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2175777at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN55170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="175" mass="20469" checksum="21F88EDBD18FFBD5" modified="2016-09-07" version="1">MNTFISILFTILFIGVPTYYFTILFSSYYKQVRKNKDKIKVVLNVRSYTTYLAAIVLVIATIAFGIYSLFNKTFVLLLIPMILIDILVYFLIKLSSSKFYIFDNFLIIKNFYVEFSEIKNVLLKPENKDNLYELSISTKDFLHTIKIKTEDPKSLIKEFKTSLPKNIKIKEVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3S0</accession>
    <name>A0A173Y3S0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3243)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yflH</name>
        <name evidence="1" type="ORF">ERS852471_00176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262972.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57817">
        <property type="protein sequence ID" value="CUN57817"/>
        <property type="gene ID" value="ERS852471_00176"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069623at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021637">
        <property type="entry name" value="DUF3243"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024702">
        <property type="entry name" value="Uncharacterised_YmfJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038292">
        <property type="entry name" value="YmfJ/YflH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11588">
        <property type="entry name" value="DUF3243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004764">
        <property type="entry name" value="YmfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="9093" checksum="F689A4E27081659A" modified="2016-09-07" version="1">MNNSNEWNNWKEALGKAVDLGEDIGLSNNSINNIAEKVGGFLANHVEPANDEERLLKELWDVGNQHDKHVLAKLVVKMTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6F5</accession>
    <name>A0A173Y6F5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pgsA_1</name>
        <name evidence="18" type="ORF">ERS852471_00207</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263029.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59459">
        <property type="protein sequence ID" value="CUN59459"/>
        <property type="gene ID" value="ERS852471_00207"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUN59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="196" mass="21697" checksum="08118A51149D17BC" modified="2016-09-07" version="1">MNLANKLTMLRIFLVPIFLIFIAMKGIPYGTIIATLVFIIASLTDQLDGYIARSRNQVTTFGKFMDPLADKLLVTSALISLVELGLIPSYAAIIIIAREFAVSGLRTIAASEGKIIAASWWGKIKTVIQIISILLLLIKVNIETSPYLANLINNNSAMNKFFEFAPTIFLYLAVIVTIISGIDYFIKNKKVFSMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YHZ0</accession>
    <name>A0A173YHZ0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nadE</name>
        <name evidence="9" type="ORF">ERS852471_00250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263131.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63742">
        <property type="protein sequence ID" value="CUN63742"/>
        <property type="gene ID" value="ERS852471_00250"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="473"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN63742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="634" mass="71606" checksum="340842143AF1E062" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YIS6</accession>
    <name>A0A173YIS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipid A export ATP-binding/permease protein MsbA</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_00244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263121.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63460">
        <property type="protein sequence ID" value="CUN63460"/>
        <property type="gene ID" value="ERS852471_00244"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN63460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="569" mass="64689" checksum="385D76A65E82BFEB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMH9</accession>
    <name>A0A173YMH9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adhE_1</name>
        <name evidence="5" type="ORF">ERS852471_00259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263149.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64275">
        <property type="protein sequence ID" value="CUN64275"/>
        <property type="gene ID" value="ERS852471_00259"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="5"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="4">
        <location>
            <begin position="456"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN64275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="883" mass="96807" checksum="B073BDF1576E8E8F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNI4</accession>
    <name>A0A173YNI4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yceG</name>
        <name evidence="7" type="synonym">mltG</name>
        <name evidence="8" type="ORF">ERS852471_00276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263175.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65163">
        <property type="protein sequence ID" value="CUN65163"/>
        <property type="gene ID" value="ERS852471_00276"/>
    </dbReference>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN65163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="38816" checksum="6A392EAD4A978FDB" modified="2016-09-07" version="1">MNFKSKRLIKIAMVTILCFIIVGIVAFKSVIDKPLKIVSDYQVTIDEGESFYSLLNELKSEGVIKNTVIIKAYTKINRLNLDIIPGQYIMNKDMSIKDIIELLKRESEDSYINFTIPEGFTIDDIAEKLENEGICKSDQFINAVKEYPLPSYIKENSEKRYNLEGFLFPDTYKFEKGIKPEAIVQTLLNRFDEVWNEIITNLGVEVNNDDIENIITVASMVEKEARVDEERATIASVIYNRINENMTLSIDATVLYAHGYHKDKLYYKDLEIDSLYNTYLYKGLPIGPISNPGAPSIIAALKPEDTDYLFYVLESDNKHYFTNNDEDFMKKQEELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPH8</accession>
    <name>A0A173YPH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase U32</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbU_1</name>
        <name evidence="2" type="ORF">ERS852471_00278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263179.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65257">
        <property type="protein sequence ID" value="CUN65257"/>
        <property type="gene ID" value="ERS852471_00278"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="320"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="411" mass="47374" checksum="7F0C999887433997" modified="2016-09-07" version="1">MRKPEILAPAGNLEKLKIAVDYGADAVYIGGGRLNLRAFSNNFTTEQIIEGIKYCHDRGRKLYVTLNVFPRNHDLEGAESYIRELYEIGVDAVIVADPSLVAICKEVAPELEIHLSTQANTVNWRAVKFWYELGVKRIVLARELTFKEIKTITSYMPNGCDIEAFVHGSMCVAYSGRCLISNYMLGRDANKGICGNVCRYKYYLVEETRPNEYYPVVEDDNGTYIMNSKDLCMIKHIPELIESGIYSFKIEGRMKSEFYVASVVKAYREAVDSYLKNPYEYEFKDEWMDILTKISHRKYHTGFYLGINGEENYDESSYLRDYDLVGMVKEYDEETGVATILQKNRVFENDEVEVLRAEDPYFKVTLTEMFDMDKNVKTDVANRAHMMFKAKVNKPLKKNDMLVKASKKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWJ7</accession>
    <name>A0A173YWJ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal/vacuolar-type H+-ATPase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263269.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67910">
        <property type="protein sequence ID" value="CUN67910"/>
        <property type="gene ID" value="ERS852471_00326"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1602369at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="178" mass="20707" checksum="16C1E9FB591E41F0" modified="2016-09-07" version="1">MNKLELNIIDLLEYLQEMLDSSAKMPITGKVMVDKKEFKEVIDQVINYLPDQLKKAEWVMNEKDRILSEAQKEFEIARRESAQLMKEKVENHDLVKEAKIRANEIIALAQRDAKAIRVGSREYSNEILLELDKEVENKKIELITAMQESFEKAAKEIDEKLSDTGKIIKENIAELRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z3X3</accession>
    <name>A0A173Z3X3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fabH</name>
        <name evidence="11" type="ORF">ERS852471_00371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263346.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70430">
        <property type="protein sequence ID" value="CUN70430"/>
        <property type="gene ID" value="ERS852471_00371"/>
    </dbReference>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="235"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN70430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="35248" checksum="2B49A5C6EF1DEC9C" modified="2016-09-07" version="1">MKGVKIVGIGHYCPSNVVSNEYISSLVDTSNEWIIKRTGIKERRISSGEGTVDIAVKASEEALKNSGYTSEDIDLIIVATTSPDRIMPSTACSVQERLGCANATAFDISAACSGFVYGLIVANSLLKINEKTRALVIGAEVLSRIVDWKDRNTCVLFGDGAGAAILEISDECGIIGTYFGSDGERGVKALTSTSLSLNNPFVKECDEEKRYIDMEGREVFRFAVSIIPIIVNNLLEKSGEKIENIKYIIPHQANSRIIDEASRRLGITSDRFYINLERYGNTSSASIPIALDEMVKKELIKKGDKIILAAFGGGLTWAGTLIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5P3</accession>
    <name>A0A173Z5P3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acpP_2</name>
        <name evidence="1" type="synonym">acpP</name>
        <name evidence="5" type="ORF">ERS852471_00372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263348.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70488">
        <property type="protein sequence ID" value="CUN70488"/>
        <property type="gene ID" value="ERS852471_00372"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN70488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8477" checksum="2A2B7AAA97E4054D" modified="2016-09-07" version="1">MIFEKIRGIVADQLGIEEENITLETRFIEDLNADSLDLFQVIMELEDEFNVKVEDVENIKTVGDAVKFVESVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAL1</accession>
    <name>A0A173ZAL1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RnfABCDGE type electron transport complex subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263433.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72977">
        <property type="protein sequence ID" value="CUN72977"/>
        <property type="gene ID" value="ERS852471_00422"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1381933at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="257"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN72977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="340" mass="34523" checksum="7E484ED5E13098EB" modified="2016-09-07" version="1">MSKQSSILRPTLVLGLITLVVSAVLVLTYNLTGVGVAGPAISDEMLAMAVDVLPGGEGFDDAGVGSSATVPAVIGTSNDAGYVINAIGKGYGGDMSVLVGLDNDGKITGVKVYEMSETPGIGTKVTEDADFLATFIGKTSVDGSDAVSGATFSSKGLNEAITNAFDAFNIIKSGGQLEGGSAPAGDSNEKAEEKPAEPAVEYKAAKDVTIDDVKEAAKEVLVDGDNFEEVSVEADNVNFVLKAENGAGYVINSVGVGFYDDDISVVIGFDADKNITGVKVVGISDTPGIGTQVAEAEFLNQFVGKSEIAEDIVVSGATFSSTGLNEAVRAAIEAVKGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZF93</accession>
    <name>A0A173ZF93_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminoacid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">steT_1</name>
        <name evidence="6" type="ORF">ERS852471_00455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263497.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74767">
        <property type="protein sequence ID" value="CUN74767"/>
        <property type="gene ID" value="ERS852471_00455"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="455" mass="49114" checksum="A9F611320523486B" modified="2016-09-07" version="1">MSNKLDKKYGLLTAIAMVIGIVIGSGVFFKAEKVLTATGGNLLLGIIAWIIGGIIMIACAYTFAVMATKYEYVNGVVDYAEAAIGKTYGYYVGWFMAVIYYPTLTSVLAWVSARYTCVLFGFSITGGECMTIACLYLIGAFAMNSLSPVLAGKFQVSTTIIKLIPLLLMAVVGTIVGITSGMTVANFTIIVEKVDTFSGLFTAVVATAFAYEGWIIATSINAELKDAKKNLPRALIGGTFAIMLVYILYYIGLAGAVSNETMMAGGEAGAKLAFETVFSSIGGSLIFVFVIISCLGTLNGLMLGCTRGLYSIAVRGRGPKQDVFKQVDNITNMPTNSSVIGLLFCGIWLLFFYGANLTDSWFGFLSFDSSELPIVTIYAMYIPIFIMMIKKETELGAFKRFVMPILSICGCIFMMIAACFAHRMAVVAYLIVFVVIMIIGAVFENKAFIKTQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFQ5</accession>
    <name>A0A173ZFQ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263487.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74499">
        <property type="protein sequence ID" value="CUN74499"/>
        <property type="gene ID" value="ERS852471_00450"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1481953at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="DUF2263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02452">
        <property type="entry name" value="TIGR02452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2263" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="259" mass="29783" checksum="C5605D669F908A09" modified="2016-09-07" version="1">MNNEKLRDVVKENFEIAKNNFYISKNGKKVELDNKVEDMIDKTELVNNEVTYVENYKEIQKNYIVRDNIINLGTIDTILKLRNEGVRGNIIVLNFASAINPGGGYLSGSKAQEESLCRASMLYESLKKQNDFYKFNRENYTPLYNDRMLYVPNVPIIRNDTLELLDNYELASFIVSPAVNRRKAYAEGVRDEKLLVDIMSKRIEKIVKLAISKKPTVLILGAFGCGVFGNDREVVYDIFEKCIREFVPVEIKVIFAVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJ49</accession>
    <name>A0A173ZJ49_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate anaerobic carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263543.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76251">
        <property type="protein sequence ID" value="CUN76251"/>
        <property type="gene ID" value="ERS852471_00484"/>
    </dbReference>
    <dbReference type="OrthoDB" id="350103at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN76251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="476" mass="50975" checksum="8FE4378A82E220FC" modified="2016-09-07" version="1">MLNLQKKQNNSDDVMKKEIKMPHTLVIIFGIILLVAVATYFVPGGAYERVVNEAGRTVVVDGTFSYIESNPQGLFAILQAPFEGIISAAEIIAFLFIVGGAINVVSRTKAIDLGIVKLVDKLKGREILIIPILTFIFSIGGAVFGMSEEAIPFITLLLPLMLALGYDSILTVAVTYLACILGFSTAMLNPFTVHIAQNIAGVEVGSGVGFRTIAWCITTTVGIILLMLYAKKIKKDPTKSLVYESDKKKKEKLDLNVNSHEEFTIKHKVILSLLAVSIGVIVWGVLAKGFYISEIAAVFLAMGLISGIIGRLSVNDMADAFIEGAKGMIGAAVIIGCAKGIVILAENAQIIDTVLFGLVGLIGKLPSLIAAYLMYIVQMIVNFFIISGSGQAAVTMPLLAPLGDLVGVQRQLSVLIFQLGDGFSNAIFPTSGILIASLGLAGVPYSKWLKWILPIQAVMFTLSIGFITVAMMINWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTT0</accession>
    <name>A0A173ZTT0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ogt</name>
        <name evidence="9" type="ORF">ERS852471_00493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263585.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79059">
        <property type="protein sequence ID" value="CUN79059"/>
        <property type="gene ID" value="ERS852471_00493"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN79059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="16905" checksum="63BE7137C5258BEB" modified="2016-09-07" version="1">MNYGYYESPIGKIKIEAEGESIIGVSFSMESSEWDENEAVIKCKNQLQEYFEGKRKEFDLNIKFIKGTEFQISVWKALSNISYGEKVTYKSIAEKINNPKAVRAVGGANNKNPIAIIIPCHRVVGSNGKMVGYAGGIDKKEYLLKLEEKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4V3</accession>
    <name>A0A174A4V3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83193">
        <property type="protein sequence ID" value="CUN83193"/>
        <property type="gene ID" value="ERS852471_00548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="7336" checksum="5F56F1743CA09477" modified="2016-09-07" version="1">MDLKERINGFVIEQQQLLLKMDMYFLPIDKLSEYRAYPTFFKDRLKSIKDGIEHIVTYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A659</accession>
    <name>A0A174A659_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mta</name>
        <name evidence="6" type="ORF">ERS852471_00547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83006">
        <property type="protein sequence ID" value="CUN83006"/>
        <property type="gene ID" value="ERS852471_00547"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN83006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="30841" checksum="4B7B818E09C3A148" modified="2016-09-07" version="1">MEYSIKSLAKLAGISTRTLRYYDEIGLLKPLRINSSGYRIYGDKEVDILQQILFYKALELPLEKIKEIITSKDFDPKTALYDHKENILRKQEELRRLLINVEKTICSLEGGNEMSAEEKFEGFKKKKIKENEEKYGKEIREKYGEEKVKESYAMFGKLSKEQWSEAEKIGTLINETLKEAMSEGNPKGEKAREVVELHKKWLSFFGNYPVQAHLSLGQMYVDDERFSDYYDNAAGEGAAIFLRDSIAAYYNAKFNEETWQWIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AC88</accession>
    <name>A0A174AC88_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoR_4</name>
        <name evidence="9" type="ORF">ERS852471_00577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85360">
        <property type="protein sequence ID" value="CUN85360"/>
        <property type="gene ID" value="ERS852471_00577"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="239"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="494" mass="56849" checksum="85C5E2C8774A2F19" modified="2016-09-07" version="1">MESVFNCIDECIMVLDEKNIIKFCNKSLLNILGYNLNDIQKKNLINIIQGINNFDSDGEVIIYNKENTPVQFTYKVNNAIWKGNSAKILVLKEKELYTKADLEKILENIPLLVWMRDLEGKYIYVNRAYCDFMKLSKDEIIGKRDRDFLCKEDSSVIEEEDRRLIKEKCNIIEQEELRIKNKLALFFVAKDVAVDKDGDVKYVFGVAHDITDIKKIEEKRRELEKEIEVEKIRNEFFNNISHEFKTPLNVLLSTTQLIGSHIKERDIKEISGEKIKNYIEMIENNSYRLLRLTDNLIDMTKIDTGEYKINLENKDIVSIVEDVVLTACDCMGNFSGEIIFDTNVEERIVACDQEKIEKVILNLLSNAVKYGNDNGEIFVNINSYEDSVEISVKDNGIGISPENINNIFERFGQEDKSLSRKQEGSGLGLALVKSVVEMHNGTINVQSELGKGSNFIITLPAKRVVKSEQLKFNICNQTIFEKCMIEFSDIYAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AF37</accession>
    <name>A0A174AF37_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263749.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86106">
        <property type="protein sequence ID" value="CUN86106"/>
        <property type="gene ID" value="ERS852471_00586"/>
    </dbReference>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="10"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="410" mass="43682" checksum="31E03E89F9D3335B" modified="2016-09-07" version="1">MIKGIILLTVFVVIAFFVGKLVTKVKLPSILGWLLTGMIIGPHALNWMTQGLLDSNWFHILSNVGEVTAGMLIGTELILREIKKSGKQIVTITIFEGLITFIIVAIAFFFVEDIPMSIALIFGGIALATAPAPSLSIVREYKANGPVAKTLIPLAALDDILAVIVFFLVIGGVSSMYTGGRIQILPILMMVILPMVVGGITGYISGKILRKSCDKKETIIKNMLLIIVTAMIGRFVSQNILEINLLLVGIAFSAVIANMVSEERLKEIMGAMNPIIAVALMLMIVALGAPLDYHLILGAGALTAVYIIARAIGKILGAYLGGKISKADKNVCKYLGLSLLPHSGVSLLFTGIAVTTLLPIAPEYATMIQGTIAAAAVINEIIAVFLAKQAFKMAGEIKSEKQIPDSKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174APJ6</accession>
    <name>A0A174APJ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ypdC_1</name>
        <name evidence="2" type="ORF">ERS852471_00641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89520">
        <property type="protein sequence ID" value="CUN89520"/>
        <property type="gene ID" value="ERS852471_00641"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="190"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="294" mass="34620" checksum="55A6135D1234F9A3" modified="2016-09-07" version="1">MKTMEVKSVLNKIRNKKENKNGIYNIRLIEGEEGILSNEKGDIILIVAFGQGSITIDSKVINLFSGNIILLKQVGEIKYNIKDKNEICFVKLKKEFITTQLIAQMADCPILYDFLRLDTSQMEYLLFDITMQEVVKTYLNILLYELSSNDEENYKLVKASLILFLTNLHKVHQEALIISESSMMKDYDIGKWLKYMVDNYSTVTLRSMAEHFNFNPTYFSVRFKVLANCQFSEKLLEIKLEKARWLLVTTNLTVQNIVEMIGFKEKSYFYRVFKKQYKMTPLQYRKHYKLAYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVN1</accession>
    <name>A0A174AVN1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-metabolising metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263896.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91556">
        <property type="protein sequence ID" value="CUN91556"/>
        <property type="gene ID" value="ERS852471_00668"/>
    </dbReference>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN91556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="432" mass="49382" checksum="2AED4CD974059C32" modified="2016-09-07" version="1">MVLKDKKTKITFHSGVLTIGGTIIEIAYEDSHIFFDFGSEYNPAAKVQPTDLQGLLDENLVPFLDNMFDPKIPLKGYESKENKFDNTAVFLSHMHLDHSKIINYLNPEVPLYTLEGTKSLLNTLNINNDFIFPLYNNDGTKNTRDIIGVKENEIVQVGKIKVKVMPVDHDAYGACGLFIETPDLTIAYTGDIRLHGYRKSDTLNFCKESENCDVLLIEGVSVSFQDFGDPIREGEPKTESELIDKINKIVNDNEGKQITFNYYISNIERILNIIKNVKRTVVLDSYNAYVLKEATGYEVQYYNLDNKEYGLKKELEVNFNELLEDNEKYLWQLDANALKYFDKLKEGGVYIHCDAQPLGEFDPAFAPFVKSFADRKIEFNRVVCSGHARPYDLIEIINLIKPKLLAPIHSYHPEKLYNENGDMILVEKGQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5D4</accession>
    <name>A0A174B5D4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent aminotransferase</fullName>
            <ecNumber evidence="3">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PatB</name>
        <name evidence="3" type="ORF">ERS852471_00713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263993.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96037">
        <property type="protein sequence ID" value="CUN96037"/>
        <property type="gene ID" value="ERS852471_00713"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN96037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="45451" checksum="BD01E7FC7E1A629F" modified="2016-09-07" version="1">MYNFEDILQRRNNGSKKWNEEYIEKRFKVKDAANYYPLFIADMDFKLPKEVIEPLMEFIALGDFGYFDIKEEFYSSILKWYKDRYRSEIKREWIVPSIGALSTMNVIVDKLFKKGDNILVFTPAYGPFKDVVSNNGMNLVSYKMKLNNNKYTLDFKEVKALVEKEDIKGLIICNPHNPSGRCWSKEEINEIINICMEKNIIIISDEVHGDLDLGNNFNTFSDYLNQYKNIIVLSSPNKTFNIAGLEISTFLCSNEEMRIDLANELSKRKLHPNRVGTRALTLCYENGSPWVDELIMNIKENLDLTVDMLNVEGISTMVPDAGYLLWVKFDNISDIDDFIIKLAQEKKVLLETGSRFIKDHEGYLRINVATSKAILKEAIPMIVEFYKEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B6C7</accession>
    <name>A0A174B6C7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264008.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96492">
        <property type="protein sequence ID" value="CUN96492"/>
        <property type="gene ID" value="ERS852471_00722"/>
    </dbReference>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="173"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN96492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="338" mass="37663" checksum="DF6062E3F7C76188" modified="2016-09-07" version="1">MKMIRVEDAIGCILSHDVTQIIPGEFKGRVFKKGHIIKEEDIQKFLEIGKEHIYVWEPKEGELHENDAAIRISNLVVGEGVAKSEEIKEGKVDFFADRDGVLRIDKEKLFTINSIGEIIVSTLHNNTPIKKGEKIGATRVIPLIIDEKPILKAEELVNDKVIWVDEIKPKRCLLITTGNEVYKGRIKDAFLPVIKAKLGYYGSEVVRQVILPDEKERIIEEIQKGLEEKVDMIICTGGMSVDPDDVTPTAIKESGGELVTYGSPVLPGAMFLLAYHNDTPILGVPSCAMYSKRTVLDLVLPRVLADERLSFEDIAHYGHGGLCLDCNVCTFPHCSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDW1</accession>
    <name>A0A174BDW1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97950">
        <property type="protein sequence ID" value="CUN97950"/>
        <property type="gene ID" value="ERS852471_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN97950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="55" mass="6648" checksum="AB1280D102940EE3" modified="2016-09-07" version="1">MVEGKFNNKQLVLNKREREVFYNRFLDMEERFEGALIDFREGKVNLENITNDISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHT5</accession>
    <name>A0A174BHT5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_00800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264162.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00621">
        <property type="protein sequence ID" value="CUO00621"/>
        <property type="gene ID" value="ERS852471_00800"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940849at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06920">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006635">
        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037250">
        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05031">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00725">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158911">
        <property type="entry name" value="SSF158911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50978">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018453" evidence="3">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="4">
        <location>
            <begin position="35"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="217" mass="23700" checksum="3C31F64F56B8BC3B" modified="2016-09-07" version="1">MKILNKFNSILTAVMVLRVFFAMGTKSAYAADADIASGIYEVENEVYHESETGMAMSRSYLLPTMEVEVTKDGIVYTIGFSGSDYMENYRMLVNGEDTAVEMVDEVTEEGIVKLKVEVDKVDADMDALIYVAPMGRDVQFKVIPKMETLTLIEAIEEAEEVIEEVVAEDLIEEVVTEVDATSGASENYKTMAVAGGVAVVVIAGIVAVLVIKAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BI43</accession>
    <name>A0A174BI43_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">High-affinity heme uptake system protein IsdE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Iron-regulated surface determinant protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Staphylococcal iron-regulated protein F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">isdE</name>
        <name evidence="10" type="ORF">ERS852471_00801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264164.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00662">
        <property type="protein sequence ID" value="CUO00662"/>
        <property type="gene ID" value="ERS852471_00801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019957">
        <property type="entry name" value="ABC_transptr_haem-bd_IsdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03659">
        <property type="entry name" value="IsdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018454" description="High-affinity heme uptake system protein IsdE" evidence="8">
        <location>
            <begin position="27"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="9">
        <location>
            <begin position="49"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO00662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="32429" checksum="7279A091D12E9AC1" modified="2016-09-07" version="1">MKYKRIMSIIAAGIMSLGLISCGSKAAEENVVVEANGGEVAVEADSEEVVVATSVAVTEILDALGVKVSGIPQTSYELPESTKGAVEVGSPMSPDLEIIKSLNPTVVVSVDTLGSDYMELFTQNNIPSEFVSLESLNGLKEAINTLGKRFDKETEAESLLANLEAKEKEVAEKAAQLESPEILVLFAAPGSTMIATSKSYVGSLVEMVGGKNIIADNSTSFTTYNKEDLSMLNPDKILVMVHALPEETQAALEKEMATDAAWQNIEAVRNGDVVYLDTSYFGMSANLKAIEGLDILSDIVHGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C1A0</accession>
    <name>A0A174C1A0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264318.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06109">
        <property type="protein sequence ID" value="CUO06109"/>
        <property type="gene ID" value="ERS852471_00877"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904998at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="14043" checksum="5EA8133C34C77AEB" modified="2016-09-07" version="1">MINKLSKEKYFKYDSKELLGVMRFDFYDGRLSNQWNPRELIIELNDNKLIDLKKLQQELNYIQFTLIEEFNKVVELCNGTGYDKETLVYIEIEEGKYVIKLIPVKDSYSYIYTYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C568</accession>
    <name>A0A174C568_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Fusion: PTS system, beta-glucosides specific IIABC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sacX</name>
        <name evidence="15" type="ORF">ERS852471_00895</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264352.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06918">
        <property type="protein sequence ID" value="CUO06918"/>
        <property type="gene ID" value="ERS852471_00895"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196185at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010973">
        <property type="entry name" value="PTS_IIBC_sucr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01996">
        <property type="entry name" value="PTS-II-BC-sucr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="110"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO06918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="458" mass="48271" checksum="E63B0C48A350C2BF" modified="2016-09-07" version="1">MGSNKYFDCANKILQFIGGNENVASAAHCATRLRLVVKDESLINKEEIENLDLVKGAFMNGGQFQVIIGQGIVNKVYAEFANITGIKEMSTADVKAEGAKKLNPLQRLAQVLSDIFVPIIPAIVAAGLLMGLLGLAGKFGLEQYSNTWWWMMLDWFSSAAFNFLPILVAISAAKVFGCNPYLAATVGGIMIHPTLQNAWTQGTGYETIKVLGLIDMPLLGYQGTVLPILIVIFVMSYIEKGTRKIVPELLDILLTPLITVLVTGFLALAVIGPAANFIGAGISTFLTFAIDKLGIIAGLLFGGAYSSIVITGIHHSFHAVELSVLAETGVNTLLPIWSMANVAQGGACFAAFLLTKNKKMKAIALPSAISTLFGITEAAIFGVNLRYKTPFIGAAIGGAIGGAYVVAMKVGMTAVGVTGIPGMAITASGSTLHYIIGLVIAVGVAFVATMFMGIKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7Q9</accession>
    <name>A0A174C7Q9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore photoproduct lyase</fullName>
            <ecNumber evidence="1">4.1.99.-</ecNumber>
            <ecNumber evidence="1">4.1.99.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">splB</name>
        <name evidence="1" type="ORF">ERS852471_00943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.99.-" evidence="1"/>
    <dbReference type="EC" id="4.1.99.14" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264449.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09541">
        <property type="protein sequence ID" value="CUO09541"/>
        <property type="gene ID" value="ERS852471_00943"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1341636at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003913">
        <property type="term" value="F:DNA photolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023897">
        <property type="entry name" value="Spore_PP_lysase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034559">
        <property type="entry name" value="Spore_PP_lysase_Clostridia"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00412">
        <property type="entry name" value="spore_photoproduct_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04070">
        <property type="entry name" value="photo_TT_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO09541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="39753" checksum="2E4A707459ED6727" modified="2016-09-07" version="1">MFIPKRIIFEKGSLDYEIGQNVYNYFKDNTKVEKIILTSNKVKQNIPYNDYLPEFYKEGKRTLVVGVKKGLKFQSCKPSAHYQLPLYSGCMGQCQYCYLNTNLGDKPYAKINSNIDDILKQAQKYIDERLPSITIFEGSATSDPLPMEPYAGSLKKTIEFFANNTNGRFRFVSKFNDVDTLLDIKHNGKTEVRFTLNTDKVINEYENATASITLRLEACEKIANACYPLGFIIAPVFLYNNYKEDYKKLLLDLREKLPKSMKNPPSFEVISHRYTTRAKNVIMEVFPENTLPMNDDERKYKYGQFGYGKYVYKTEELDDMKEFFKKEISEIFPESEIKYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBZ3</accession>
    <name>A0A174CBZ3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ORF">ERS852471_00936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264435.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09218">
        <property type="protein sequence ID" value="CUO09218"/>
        <property type="gene ID" value="ERS852471_00936"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO09218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="26676" checksum="902C5FDD565500A2" modified="2016-09-07" version="1">MRKAIIAGNWKMHYTPEEAVKLVNELKPLVKDATCDVVVCPTFVCLDAVLKAVEGSNIKVAAQNMHFEEKGAFTGEIAPRMLEAMGVDYVVLGHSERREMFNETDEALNKKVKAAFAHNLTPILCCGETLEQRENGTTNEVVGAQIKADLEGLSADLAEKVVIAYEPIWAIGTGKTATDEQANETIMAIRGIVAEMFGKEVADKVRIQYGGSVKPGTIKAQMAQSDIDGALVGGASLVASDFAAIVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CH47</accession>
    <name>A0A174CH47_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">soxS</name>
        <name evidence="5" type="ORF">ERS852471_01001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264534.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12523">
        <property type="protein sequence ID" value="CUO12523"/>
        <property type="gene ID" value="ERS852471_01001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="301" mass="34481" checksum="6FC5DA377ECE7617" modified="2016-09-07" version="1">MNNKKINYFPVLEEDRVSRYLAALKYKLITFGIWQQNEDVPMHNEVLGHFKFIYITNGSCTLTIGNVDYEVKSGDTLLFPPFITYRATCHQGEELKFYFLHFDVAPVDKRNLLTMLLDLQDIAIYKGLITERSIANLGNLNQQLLDNKPGIYYNISNLLHSTIFAALNASEPSDLLGLASEVAATNEELIIQDCAKYIDTYIHEQIQVDDLCRHVNVSQSYLYKCFTTVLGVSTKDFIQKHKLRKISVELLSKSIPLQELADKYGFSSANHFSTVFKKYYGCSPSAYKQKHLEKFNLENSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CS65</accession>
    <name>A0A174CS65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BadM/Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nsrR</name>
        <name evidence="1" type="ORF">ERS852471_01044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264579.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15984">
        <property type="protein sequence ID" value="CUO15984"/>
        <property type="gene ID" value="ERS852471_01044"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1765806at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="131" mass="14699" checksum="372762A17F9D3AB3" modified="2016-09-07" version="1">MQLSKFTDYAFRVLIYLANNRDKLSTVEELAVELNASEHHIKKVVHKLAKTDFIISIKGRTGGLKLGLEPEEINLGDVLKLTEDNLNLIECFNKPDSCPFMAPGCKLKGISAGALNRFIDEFSKYTLKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CSR0</accession>
    <name>A0A174CSR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">appA_2</name>
        <name evidence="3" type="ORF">ERS852471_01051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16402">
        <property type="protein sequence ID" value="CUO16402"/>
        <property type="gene ID" value="ERS852471_01051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019458" evidence="1">
        <location>
            <begin position="27"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="95"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO16402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="530" mass="58797" checksum="151AF96A4D855C01" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CT47</accession>
    <name>A0A174CT47_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiE_1</name>
        <name evidence="2" type="ORF">ERS852471_01054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264588.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16542">
        <property type="protein sequence ID" value="CUO16542"/>
        <property type="gene ID" value="ERS852471_01054"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="28520" checksum="A1B6B05E16312D24" modified="2016-09-07" version="1">MSYLEDIKSYWNKRAEGYSISNRESLNSDEKEEYEEVLKKYINKDEKCKAIDMGCGPGFLAILLANLGCESYGFDCTENMLLEAEENSKQVGVKIHTIKGDAQNPHIEDNTFDLLVSRNLIWNLENPEKAYKEWIRILKPGGKIIIFDGNHYCYMFDERYMEERESVTHVNDHKNMMGVSTEAIDKIAYNLPLSREIRPQWDKEVLESLGARIIDIEINEVSYKNKQNEDIKLIKSFKIVCEVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUV4</accession>
    <name>A0A174CUV4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264593.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16807">
        <property type="protein sequence ID" value="CUO16807"/>
        <property type="gene ID" value="ERS852471_01060"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2051345at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO16807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7292" checksum="3F445F9225DA5F1B" modified="2016-09-07" version="1">MSKLTNVNKKIENTVVTKYKKIENAVVSKYQKIEDKFIDTFLAEDGETTSQAKDRIKENIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DHU3</accession>
    <name>A0A174DHU3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
            <ecNumber evidence="2">1.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemG</name>
        <name evidence="2" type="ORF">ERS852471_01197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264708.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23470">
        <property type="protein sequence ID" value="CUO23470"/>
        <property type="gene ID" value="ERS852471_01197"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO23470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="171" mass="19781" checksum="6FFC910F9C799D9C" modified="2016-09-07" version="1">MKTLIIYGSNHGCAKKCAELLEENLKGEVDIVDIRKDITLDLNNYDKVVIGGSIYMGKIQKEIEEVCESYCDNLKEKKLGLFICCMNEENVEKQIKDNFPEKLILSAKVQGYFGGAFNFKDMNFFERFIIRKVFKSLANTNDKFKGIDMKKFVDMIERENIENFAKAMNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DI26</accession>
    <name>A0A174DI26_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="2">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagE_1</name>
        <name evidence="2" type="ORF">ERS852471_01206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264725.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25094">
        <property type="protein sequence ID" value="CUO25094"/>
        <property type="gene ID" value="ERS852471_01206"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="368" mass="42415" checksum="9869B7AF84C696FD" modified="2016-09-07" version="1">MKKKVVFFLEHLEGGGAEKVAVDVLNKINKKKYDITLVLLFGEGVNIKNLDREINVKTIIKKPFGRIGNKIVFNFMKYMPGLFYKLFIPKESNIEVAFLEGFATKIISYSTNKESKKIAWVHTDLSQNRWTNYAYKRNEEISCYRKFDDVVLVSKDAYLGFDKVFNIDNINKHIVYNPIIIENIIEKSNEREISYNEFTIVSVGRLVNIKGFDRLIMAHAKLVREFPHRLVIIGEGEERRNLEQLVNTLGVNESVDIMGFIENPYPYIKAANLFVSASKTEGYGVAVAEAILLEKPVMITNITGTVEVLGDKENGIVCENSQEGIEKGLEYILQNKNLLGYYKKKSIERRSFFQYNMRINEIEEIFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSA2</accession>
    <name>A0A174DSA2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="2" type="ORF">ERS852471_01247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264779.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27159">
        <property type="protein sequence ID" value="CUO27159"/>
        <property type="gene ID" value="ERS852471_01247"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="22878" checksum="338C67D361269EB2" modified="2016-09-07" version="1">MIKIGLTGGIGSGKSTVSAMLKEAGFPIIDADIIAKSVLEKYPEILEKVKIDFGVGFFDWRGQFRRKEFGNHIFRFPKQRIKYEALILPYIIREIEDELKELEKKGEKKVIVDAPTLIENDLHKEMDYVILVWVDSNTQLQRVRSRDSLSREDAINRINAQMPLERKKDFANIIIENNDTLLKTKVQVESLIEFLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWF5</accession>
    <name>A0A174DWF5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid carrier protein AlsT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_01273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264827.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28375">
        <property type="protein sequence ID" value="CUO28375"/>
        <property type="gene ID" value="ERS852471_01273"/>
    </dbReference>
    <dbReference type="OrthoDB" id="883596at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO28375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="473" mass="50858" checksum="F7EFD14B65E07E10" modified="2016-09-07" version="1">MDKIHSIILHINDFLWTYVLIISLITIGIYFSVKTNFIQFRRLKDMFKLLGEGSSEKGSVSSFQAFCIGTASRVGTGNLAGVASAIAVGGPGAVFWMWLIALLGSASAFIESTLAQIYKVKDGDSYRGGPAYYMEKGLNKKWMGVLFSILIIICFGFAFNSVQSNTIAAAFQSSFGINKTVIGTIITILTAIIIFGGVHRVAKISSVIVPIMASAYILIAMFVIAKNITAIPSLFALIFKNAFGIEQIVGGGIGAALMQGIKRGLFSNEAGMGSAPNAAATASVSHPVKQGLIQTLGVFTDTLIICTSTAFIILLSGNYASGNLTGIELTQSALISQVGSWGGTFIAICILLFAFSSIIGNYYYGETNIQFISNKKIYLYIYRIIVIGMVFFGSIASMQFVWDIADVFMGLMAVINLIAIVLLSNIAIKAYKDYATQKQAGKDPVFYASSIPELGNEVEEWTNDISSTNENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2P3</accession>
    <name>A0A174E2P3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tetrahydrodipicolinate N-acetyltransferase</fullName>
            <shortName evidence="7">THP acetyltransferase</shortName>
            <shortName evidence="7">Tetrahydropicolinate acetylase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapH_1</name>
        <name evidence="7" type="synonym">dapH</name>
        <name evidence="9" type="ORF">ERS852471_01325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:13085"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58117"/>
            <dbReference type="EC" id="2.3.1.89"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transferase hexapeptide repeat family. DapH subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.89" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264919.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30746">
        <property type="protein sequence ID" value="CUO30746"/>
        <property type="gene ID" value="ERS852471_01325"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752123at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047200">
        <property type="term" value="F:tetrahydrodipicolinate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01691">
        <property type="entry name" value="DapH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019873">
        <property type="entry name" value="DapH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013710">
        <property type="entry name" value="DapH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08503">
        <property type="entry name" value="DapH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03532">
        <property type="entry name" value="DapD_Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DapH_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO30746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="236" mass="25560" checksum="653A42FA66178981" modified="2016-09-07" version="1">MNNNNFTDPYEIARFIKDAKKVTPVKLYIKGDMDNINFSNCKVFGCGDSRIVFGEYEVIEEILENNEDKIEYYELENDRRNSAIPLLDMKNIQARIEPGALIRDRVSIGKNAVIMMGAVINIGAEIGENTMIDMNAVVGARGTIGKNVHVGAGAVIAGVLEPPSKTPVIVEDYAMIGANAVILEGVRIGKGAVVAAGSVVINDVEPNTVVAGTPAKVIKEKDDKTADKTRILEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAV4</accession>
    <name>A0A174EAV4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dus_1</name>
        <name evidence="13" type="ORF">ERS852471_01369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265003.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33579">
        <property type="protein sequence ID" value="CUO33579"/>
        <property type="gene ID" value="ERS852471_01369"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="14"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="35835" checksum="19BBB561856246D1" modified="2016-09-07" version="1">MKIGNLTFNNNVFLAPMAGVTDISFRGLCKEMGCGLVYTEMVSAKALYYGSDNTKALLRIADEEKPVAAQIFGNDPKIMAEVVEKYFNPREDICILDINMGCPAPKITKNDEGSALMKNPKLAAEIVSSIKKVSNKPVTVKFRKGYDEENINAVEFGKALEEAGADAIAIHGRTKKQMYEGKADWDIIAKVKNSVSIPVIGNGDVFTPEDALNMKKITNCDAIMIARGSMGNPWIFKQIEDVLNGKDASIVTDLERINMCIRHYELALKYDGEHKAVREMRKHASWYLKGLPNSSELRNTINSMDKSSNVIEILNEYKNVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFJ7</accession>
    <name>A0A174EFJ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YabP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265043.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34710">
        <property type="protein sequence ID" value="CUO34710"/>
        <property type="gene ID" value="ERS852471_01396"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933806at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012504">
        <property type="entry name" value="Spore_YabP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038705">
        <property type="entry name" value="YabP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011576">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02892">
        <property type="entry name" value="spore_yabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="97" mass="10970" checksum="A0C3B2776DE15B27" modified="2016-09-07" version="1">MEKKDISKIEENKGNLILENRKKLTLSGVVEVISFDEEKILLNTKLGALTIKGTELKMNKLDVQNGDVTIVGDVWSMVYSGKEMKKEKESIIGRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUE5</accession>
    <name>A0A174EUE5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphotransferase system domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ERS852471_01520</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265272.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41732">
        <property type="protein sequence ID" value="CUO41732"/>
        <property type="gene ID" value="ERS852471_01520"/>
    </dbReference>
    <dbReference type="OrthoDB" id="328780at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="113"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO41732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="474" mass="50115" checksum="49162135F9AC2637" modified="2016-09-07" version="1">MTNKELVVKIIEKLGGKENILSVENCMTRLRLDIKSMEKVNINELKKLEGVLGVVEGDGVQVVVGPGKSAKLCTIMKEDLGVKEITQNVGEWEANKEKIKSGQKQNALKKALKTIGEIFVPLIPAIIAAGIFNGFSGLITNLQSTGSLAVDSNVWNTIRSFLSLMGGGFLSYFAIFTGINAAKKFGATPAFGGMLGAMSLMTGINDISRIFGLYNEEVALKSILTTGKGGVIGVIIGVFILSIIEKKIRKIVPDVLDIILTPMLTLIISTVIFVMIIMPLSGFVSDWLVAGLGLLINSTNPIVSVISGYVLAALFLPMVLLGLHHGLIPIYALQLEALGGVSLFPVLAMAGAGQVGAAIAIYIKAKKVKNQSLTQVITGALPAGILGIGEPLIYGVTLPLGKPFITAGLGAGFGGAYAMFMHVMANAWGPSGIVAIPLMQPDSMLNFFIGLLIAYVGGFILTQIFIKENDVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWF8</accession>
    <name>A0A174EWF8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RelA/spoT family protein</fullName>
            <ecNumber evidence="4">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">relA_1</name>
        <name evidence="4" type="ORF">ERS852471_01522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265276.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41801">
        <property type="protein sequence ID" value="CUO41801"/>
        <property type="gene ID" value="ERS852471_01522"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938730at2"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="3">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO41801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="30857" checksum="A103A56055968270" modified="2016-09-07" version="1">MAIQSWKTFLLPYEQAVEELKVKLKSLRKEYRKRNEYSPIEFVTGRVKEVSSLLEKANKFGIPLDRVAQEMEDIAGIRIMCQFVDDIDKVVELLRARKDMQILYEKDYVRNVKASGYRSYHVIIKYLVNMADGPKEILAEFQIRTLAMNFWATTEHSLNYKYKQHIPDEIKVKLKRAADAAFDLDEQMLEIKDEIKDAQKLFEVKSDIISNIMNNILILMSSGKVAEASRYQVALNRLIEEGEVYELSNLLAMIKKDIEKYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXX5</accession>
    <name>A0A174EXX5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ywqF_1</name>
        <name evidence="12" type="ORF">ERS852471_01546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUO42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42833">
        <property type="protein sequence ID" value="CUO42833"/>
        <property type="gene ID" value="ERS852471_01546"/>
    </dbReference>
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        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="313"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="249"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="35"/>
        </location>
        <ligand>
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        <location>
            <position position="86"/>
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        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="204"/>
        </location>
        <ligand>
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        <location>
            <position position="257"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="263"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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            <dbReference type="EMBL" id="CUO42833.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
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    </evidence>
    <sequence length="439" mass="49272" checksum="1CD79F2F4CC06585" modified="2016-09-07" version="1">MKIVVAGTGYVGLVTGACLSEVGHNVTCVDIDEKKVQIMKQGISPIYEPGLDQILDKNYKEGRLNFTTDYKESYKNADIVFIGVGTPEREDGSANLDYVFEVCRQIAENLENDCLVVIKSTVPIGTNDKVEDFLRYNLVNNVHVEVASNPEFLSQGTAVYDTLNASRIVIGVESKKAEMMLREVYERFGQPIVVTNRRSAEVIKYASNDFLALKISFMNEMANVCEVVGANIEDVAKGMSYDSRIGSKFLNAGLGYGGSCFPKDTKALHWLANDHGYEIKTIKATIEVNENQKYKLFRKAKNIFGDLRGKKVAVLGLTFKPGTDDLREAPSIPNIRRLINEGAEIVAYDPVGIDNFKRIFPTEIKYSNSIEEALIDADMAFIFTEWEEIKSFNISKYTEIMNNAVIFDGRNCYDLSEIEKENIDYYSIGRKEILNISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4P3</accession>
    <name>A0A174F4P3_9CLOT</name>
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        <submittedName>
            <fullName evidence="1">Four helix bundle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01577</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="117" mass="13419" checksum="AD5A1DC7EFD62856" modified="2016-09-07" version="1">MKSLSLLQLSKIIADDSIYISNELVNKNEFVISNQLKKSCTSIGANIREANYAESKKDFIHKLHIAIKECSESIYWLDIMKDNEMLDDNKVKEVYNNCFSVKRMLLASINTAKKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F5M9</accession>
    <name>A0A174F5M9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="34825" checksum="E2C677F9DCB7B951" modified="2016-09-07" version="1">MSSNGFTRVSNMILNDSDLNIYEKYFIIALKSFDYKNIGEVYPTYESLMALFGTKNRNTIASLIKSLKEKNYIITMKKNRANCYKFIKDYLSGEVKNNDIITNNLSSTSEINSNECDTGGVDLNATSNSSDTSNSNRSDTTEVKLNTSSNSSDTSNSNVSDTSNSNRSDTTEVKLNTSSNLSDTSSSITTDTLIKQYKNKKEIYIRIFDKWNEKNISNELTLTKNIASCIESVLRVFTIEQILQAIDNYAEVYHSKFYYDYLWDLKSFLIKPNGIYKFTYEGHLWKSYLNTSKEKVKIKASEYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FD81</accession>
    <name>A0A174FD81_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.250</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshA_2</name>
        <name evidence="2" type="ORF">ERS852471_01617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.250" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265459.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46300">
        <property type="protein sequence ID" value="CUO46300"/>
        <property type="gene ID" value="ERS852471_01617"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="376" mass="42856" checksum="66F867043B6DBBA6" modified="2016-09-07" version="1">MKVCFFAHSANLTGASRSLIDLLTVCKEVDVEPYAIIPKKGLIEEELKKNKIQYKVIPYCTMVKKSTFKNILKKCINSISLLLIGKYVRDNKIDIIHNNSSLIDIGMKVAKRNNIPYLCHIRDFGGEDHKIDFINPEELYKYIEEADKSIAISDSVFNKYSNLIPKAKMVKVYNGVNLNNYDIGQRDFSSKSVTNILISGRICEGKGQFEAIKAIEYLINHNIKDIKLYVVGEGIKGEKYYDELREYVLEKKLESNIVFLPFMKDLREIREKCDIALVCSVSEAFGRVTIESMLSKQLVIGANTAATAELIEDRVNGLLYNQGDYISLANSIIFALENKIECEEISNNGYNFAKDGFSIQRTMKEIKNEYIKILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFW1</accession>
    <name>A0A174FFW1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rumA</name>
        <name evidence="7" type="ORF">ERS852471_01629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265481.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47828">
        <property type="protein sequence ID" value="CUO47828"/>
        <property type="gene ID" value="ERS852471_01629"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO47828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="452" mass="50789" checksum="E137020715D5B8A1" modified="2016-09-07" version="1">MRRGSQVTVKIDNIEFPSMGVGELEGKKIYVKGAFPGQVIKGTIKKNRENYAEAKLVEVLEKAEYEIPAPCPHFGVCGGCSSQNLTYDKQLDLLSHEICELFDSKDLPMGMYLGVKGSENHWEYRNKMEFTFGDMEKGGELTLGMHMKGKSFGVLTVDHCMIIDEDFRKVLTATVEYFRKQNLPYYRVMKREGYLRHLVIRKATNTGELMVNLVTTTQIDFDLTEYTELLKSLEYKGELVSVLHTENNSLSDAVIPEKVNVLFGRDYIVENLLGLKFKISPFSFFQTNSKGAESLYSLVREFMGDGENKVVFDLYCGTGTIGQIAAPNAKKVIGLELIEEAVEAAKENAKLNGLDNCEFIAGDVAETIKKVKVKPDIIILDPPRSGVSPKALDYVIKFNAPEIIYVSCNPKTMVENLDVLLEHGYTVEKSTVKDMFPNTPHAETVVRLTKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJR4</accession>
    <name>A0A174FJR4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265554.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49757">
        <property type="protein sequence ID" value="CUO49757"/>
        <property type="gene ID" value="ERS852471_01667"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014576">
        <property type="entry name" value="Pesterase_YhaO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033091">
        <property type="entry name" value="Pesterase_YhaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="376" mass="43754" checksum="83C9BCD4732363E3" modified="2016-09-07" version="1">MRKVKILHCSDIHFDTPFKELSKEIANNCREELLETFKRIIDLTIEENVQVLFIAGDLFDNFTVNKTTLIFIINQLKRIKDKYIFIAPGNHDPYYEKSFYNMINWPSNVHIFTGKMSKKEINELGLVVYGAGFTKKYERETLINIEELDTSKINMMVLHGDISTKDAKNDYNPISLKDIRNSYMDYIALGHIHKFSGILKEENSYYAYSGCPQGRGFDEVGKKGVILGEVYKGGVDLKFIPINKREYIVKDIDISECDTYEDIKEKLLSILDEKDRLNNLFKITLTGNIKSHLYLDIKTLVEKLKNDYYFIKVLNKTTVEMNLDELANDYSIRGKFIKRMLEKLKEANEDEKEIINRALKIGLQSLSEEEVKLNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G3G5</accession>
    <name>A0A174G3G5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265748.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55688">
        <property type="protein sequence ID" value="CUO55688"/>
        <property type="gene ID" value="ERS852471_01773"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="404"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO55688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="515" mass="60925" checksum="35F2C4CAF6D45B8D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GB19</accession>
    <name>A0A174GB19_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265844.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58256">
        <property type="protein sequence ID" value="CUO58256"/>
        <property type="gene ID" value="ERS852471_01824"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2052153at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="13962" checksum="7580A8870D7B375D" modified="2016-09-07" version="1">MREIFDEIDNIKNSIESIQDEKYKELFNQISNLLINLSDKVEEVIVKQESLEENVGYIGEDLTDIQDELFEEVTFEDLMDIEDEYIEISCKCCGKPLFVEKDALNKNNNIPCPFCNNKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GC51</accession>
    <name>A0A174GC51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pilus biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">epsF_1</name>
        <name evidence="9" type="ORF">ERS852471_01833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58636">
        <property type="protein sequence ID" value="CUO58636"/>
        <property type="gene ID" value="ERS852471_01833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="220"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO58636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="346" mass="39630" checksum="5547986532F75EDB" modified="2016-09-07" version="1">MTMRINTLLNTKHRDLQIVIENLYNLYKSGIPLFNSFELMEELPLTKEYKKSITDIRGDLGKGEGLYYSFSKYDRLYPKFFLSMLKVGEETGRLGDVLNGLYVYYKKVNLMKRRLKSSLTYPAILVFITILLVCFFVMVVIPTFQDIFISMEKEIPKVIELSILLKKFIDKSPILFIVFFSFWGVLAPATVIFYFRNNLANIIYKTPLIRRFKEYVSVVLLSIIVKSGISLSIGLERCMDIDLLGGIKEDFKFINLAILEGKSLTLALEGTSGFTRYTLAHIRLGEECGNLETVLTTLEDELFDRLNTELNRILELIQPITIVFIGGLVISFILIVILPVFEGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCT1</accession>
    <name>A0A174GCT1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">ERS852471_01870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265929.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60263">
        <property type="protein sequence ID" value="CUO60263"/>
        <property type="gene ID" value="ERS852471_01870"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="457"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="608" mass="67304" checksum="6166EC7C9654B721" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH37</accession>
    <name>A0A174GH37_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional folylpolyglutamate synthase/dihydrofolate synthase</fullName>
            <ecNumber evidence="8">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fgs</name>
        <name evidence="8" type="ORF">ERS852471_01905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265980.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61673">
        <property type="protein sequence ID" value="CUO61673"/>
        <property type="gene ID" value="ERS852471_01905"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="6">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO61673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="436" mass="49647" checksum="CE759FFA55D025C1" modified="2016-09-07" version="1">MNYNEAMKYITEVGNFGSNYGLERTFRLLELLGNPQDNLKLIHVAGTNGKGSTTAMITKMLNGLGYKVGMYTSPFLEEFEERIQINGENIPKDVLAELVTYIKPYIDKVEEEGYGHPTEFEMITVLMLLYFEREKIDFGVVEVGLGGRLDSTNVIIPIVSVITSISFDHTNLLGNNLREIAGEKCGIIKRNIPTIVFPQQEEVMDVVIKKCEKENSKLYIVNFNDAELLDIVKGDKPFQKVKIKGEKEYILELPLLGEHQIYNLALAIKVMEVVEKQGFIHLNNKAIENSVREVMWKGRLEVLSNNPLIVIDGAHNIQGITTLKNNIQKYFNYKDVYLILGILADKDVEMMVKEITPLAKKVYAVTPHSIRAELAQDLRDEIIKYNENCKAYEDYEEAFNNALKDAKENDLIIASGSLYMIGDMRKLITRNYINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHC6</accession>
    <name>A0A174GHC6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265932.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60386">
        <property type="protein sequence ID" value="CUO60386"/>
        <property type="gene ID" value="ERS852471_01873"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1275564at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="16152" checksum="BE57FE672147528B" modified="2016-09-07" version="1">MYLISACLCGVNCKYNGGNNYSKYCDDLFKSGKAILICPEQLGGLPTPRVPSEMNNEAEEILKRRGKILTKDGRDVTEEFVKGAKEVEEIAKKLNIEGAILKDGSPSCGVNYIYDGTFKGNKIKGRGITAEILVQNGISVISENDIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHC9</accession>
    <name>A0A174GHC9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_6</name>
        <name evidence="6" type="ORF">ERS852471_01907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265985.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61773">
        <property type="protein sequence ID" value="CUO61773"/>
        <property type="gene ID" value="ERS852471_01907"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO61773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="439" mass="48323" checksum="C44BC5992752344E" modified="2016-09-07" version="1">MDLVKDDVKKLFLKYFFPTVGAALVTSIYILFDTIFIGQGVGGDGLAALNIVLPIYSLVFGVGYLIGVGGSTVLGIERGRGHNDKAIDIFSLSVYISIASAALFLVVGKFFMDDIALMLGATDITISLIEEYMKIVALGFVPFTIGSTLQGFVRIDKNPKLAMIATITGGLINIILDYIFVFPLNMGMYGAGLATVLSYTISMGILLTHFLSKKNTLRLNYRCFRYKYLSRIISNGIPSFFIEMSTGVIIYLFNFQLLKFIGETGVTAYSIISNTAIIFISISNGICQTIQPIVSVNIGAKKYKRSMEFRKIAFYVAIIFGLTATILGFLFPEELIKVFVTPTEEIKQIAVVAIRMYFTAFIIMGANMVLAGYFQAIEMPKVAIIISSLRGLIVVGILIFVLPCFLGVSGIWLSVPITELITFIVAIYISNRTFKEKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJF1</accession>
    <name>A0A174GJF1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">zapA</name>
        <name evidence="2" type="ORF">ERS852471_01877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265940.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60555">
        <property type="protein sequence ID" value="CUO60555"/>
        <property type="gene ID" value="ERS852471_01877"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1802106at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34981">
        <property type="entry name" value="PTHR34981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="34574" checksum="AC405E0C46F3591B" modified="2016-09-07" version="1">MNTVTVKINGVEYNLKGKENEKYLLAVAEYVDGKFKEISANNNKLSTTAVAVLSALNIADEYFKCELDNEELVKRKNSLEEKCMALKERLKEVKVDSEEYNKTKNNEIDNLKSIICSMEEKIKEVDNLYSTIDNLHKELEETKQKLQAEKEELEKNFVTKTEELKQNFAYEKDSLTDSYDRKVEELKNALEGKKQELTLLNLKNEELKKAEVSLKDEVILKEKEIEECKYNSDEIKKLKSRINSIENEKEVLKKSNKELKFKLQNSRYKLLDLEKKLNDANFNLAIEKKIKNPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQP1</accession>
    <name>A0A174GQP1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mngR_2</name>
        <name evidence="2" type="ORF">ERS852471_01932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63577">
        <property type="protein sequence ID" value="CUO63577"/>
        <property type="gene ID" value="ERS852471_01932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="27187" checksum="1BC7086FB583FCBD" modified="2016-09-07" version="1">MKINEPIYIKIEKYLRELIDSEKIKPGELLPSENQLSEEFNVTRMTVRSAFNNLVKQGYIIRKRGIGSIVLGNKVSDNMGAMESFTKEMLRKGYEVTTKLISLLVIEADDTIKERLNIEKGENVWEIKRVRYANGEPVSYMITYMPVKMFPNLKKDDCISLYNYIRDNNYNIYKANRTIEAIISNAELINLLELDSEAPILHIEQVGILQNGEAFEYSHTYHYGYKLTLNALVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS13</accession>
    <name>A0A174GS13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266020.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63225">
        <property type="protein sequence ID" value="CUO63225"/>
        <property type="gene ID" value="ERS852471_01923"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2213498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="59" mass="6581" checksum="564C4BFFD2437B30" modified="2016-09-07" version="1">MQAFIVVGLLVAAVFASYKLAIEKQQNKIIWPAITLLIGPGIFIIQYLVSVFKNNKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZZ8</accession>
    <name>A0A174GZZ8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-fucose isomerase</fullName>
            <shortName evidence="7">FucIase</shortName>
            <ecNumber evidence="7">5.3.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-deoxy-L-galactose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">fucI</name>
        <name evidence="11" type="ORF">ERS852471_02003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts the aldose L-fucose into the corresponding ketose L-fuculose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-fucose = L-fuculose</text>
            <dbReference type="Rhea" id="RHEA:17233"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:17617"/>
            <dbReference type="EC" id="5.3.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the L-fucose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.25" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266167.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66389">
        <property type="protein sequence ID" value="CUO66389"/>
        <property type="gene ID" value="ERS852471_02003"/>
    </dbReference>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00563">
        <property type="reaction ID" value="UER00624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042355">
        <property type="term" value="P:L-fucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01254">
        <property type="entry name" value="Fucose_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005763">
        <property type="entry name" value="Fucose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01089">
        <property type="entry name" value="fucI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="9">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="10">
        <location>
            <begin position="176"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="8">
        <location>
            <begin position="391"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO66389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="592" mass="65498" checksum="2B2543EEBC690613" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3Y6</accession>
    <name>A0A174H3Y6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper-sensitive operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csoR_3</name>
        <name evidence="2" type="ORF">ERS852471_02070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69563">
        <property type="protein sequence ID" value="CUO69563"/>
        <property type="gene ID" value="ERS852471_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="122" mass="13650" checksum="B4D4D1EE100F64FC" modified="2016-09-07" version="1">MAIKEINEKKEHIHISDDGKTYIHSHDSNNGSTHKHVHQNTKAVLNRLAKAKGHLESVKRMVENDRDCSEVLIQLAAVISALTSTGKVILQEHIEHCLVEAVESGDRQAIEDLNKAINLFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4N7</accession>
    <name>A0A174H4N7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_02078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266306.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69864">
        <property type="protein sequence ID" value="CUO69864"/>
        <property type="gene ID" value="ERS852471_02078"/>
    </dbReference>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="187"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="531" mass="60550" checksum="8B655B5E4321ADD0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H748</accession>
    <name>A0A174H748_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_7</name>
        <name evidence="6" type="ORF">ERS852471_02052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266264.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68819">
        <property type="protein sequence ID" value="CUO68819"/>
        <property type="gene ID" value="ERS852471_02052"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO68819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="461" mass="50165" checksum="96B7F6376B397371" modified="2016-09-07" version="1">MGNKKRNNLGTESISRLLRAFAVPSIIAMLVSALYNIVDQFFIGRSVGELGNAATNITFPLTTSCIAIALLLGIGAASAFNLTLGEGNKDKALYFVGNSALLLFTSGVVLCIIIQIFLEPMLVFFGSPENVLGYAKSYTRITAIGFPFLIFATGGGHLIRADGSPKYSMLCNLSGAIINVILDPIFIFGLNMGMAGAGLATIIGQIFGAGLALRYMFNYKTGRLYKKHLIPRWKFVKRIISLGAAPCFNQLAMMIVQIVMNKSLTYYGALSVYGESIPLACAGIITKVNQIYMSIVIGLSQGLQPIVSFNYGARKFDRVKKAYLTAISYGVIVSIIAFLVFQFLPRQIVSIFGSGSEAYYTFAVKYFRIFLLFTFLNCFQPISSNFFTAIGKPKKGIFLSLTRQILFLLPLIVILPLFIGIDGIMYSGPIADLIAGVVSIIMIYVEFRAIGSNKLSKAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBS9</accession>
    <name>A0A174HBS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70479">
        <property type="protein sequence ID" value="CUO70479"/>
        <property type="gene ID" value="ERS852471_02094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="119" mass="14586" checksum="689FDA24D3639D38" modified="2016-09-07" version="1">MNEKYKRLSLYYRDLWWKSSCDLQLTMTKYTLEEKQRREKDFDVLIDKIIKYIESFPKDEKKRESWRIKGNDYIEKIISSERIFKLGVIDKEMKSAFIKSTKDFIKHLSLLTVLYLMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJ78</accession>
    <name>A0A174HJ78_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoP_2</name>
        <name evidence="9" type="ORF">ERS852471_02183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266506.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74291">
        <property type="protein sequence ID" value="CUO74291"/>
        <property type="gene ID" value="ERS852471_02183"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO74291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="229" mass="26605" checksum="E5B271E5BC4EB8DD" modified="2016-09-07" version="1">MFKEHVLLIDDDLLIQKALRTALAREQINTTATTSGNEALLLLKKYSYDTIIIDLVMPDIDGFELIRQIRNNNIFTPIIILSGKEEEHNKILGLGLGADDYLTKPFSINLLVSKIKAFYRRSNMYQKTINPDLTIGPFRFCQNNFQIFKNNIPLDLTAKEVLFLKFLLENPNKVFSKEQLYETIWNNTTIDDNTIMVYIKRLRDKIEDNPKAPKFLKTVWGLGYKLEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HU57</accession>
    <name>A0A174HU57_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription antiterminator LicT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78424">
        <property type="protein sequence ID" value="CUO78424"/>
        <property type="gene ID" value="ERS852471_02288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAT_RBD" evidence="1">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="53" mass="6190" checksum="5B1BBCED389CB33F" modified="2016-09-07" version="1">MGIVLTNDTIVSKVLNNNIILVRDKSVEKILFCRGIGFNKKVWPNIRSWFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZP4</accession>
    <name>A0A174HZP4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaB</name>
        <name evidence="14" type="ORF">ERS852471_02349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266767.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80374">
        <property type="protein sequence ID" value="CUO80374"/>
        <property type="gene ID" value="ERS852471_02349"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1709134at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="178"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="445" mass="49512" checksum="7276514B65557971" modified="2016-09-07" version="1">METPMMRSLPQSIEAEQSVIGAMIIDKSAIAKVLEKLKEDDFYRDGHKIIYKAIQHMFSQDMAVDLVTLLEYLKTTDNLDKAGGVTYISELSASVPTTANLSSYIKIVEEKSTLRKLIKASTAIIEESYNSGDDVGKVIDIAQKKMFDIAEKKDSKEYEPLSNVLERGFLEIERLFNNRGAITGVGSGIKDLDAKTSGFQKGDMVLIAARPSMGKTTFSLNIAENAALKEGKSVVIFSLEMSKEQLAYKLLCSQANVDMLKLRTGNLDDDDWERIARATGPLSKAKVYIDDTAGLSVMEMRSKCRKIKMEHGIDMILIDYLQLMSGSSGSDNRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEYYNKESEDKGIGECIIAKQRNGPVGTVKMAWIGAHSKFADLDLVHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I812</accession>
    <name>A0A174I812_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266878.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83304">
        <property type="protein sequence ID" value="CUO83304"/>
        <property type="gene ID" value="ERS852471_02411"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO83304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="27401" checksum="149E2AE7FD2A7571" modified="2016-09-07" version="1">MVKCNNLYDNKNIDVIASKGGVKVLEYKKDLSVNTANAMAAYYASEMNVRRRQVLIELNGNAYTISAGAMQWTSGNVKMAADVKGIGDFFGKAISSKVTKESAIKPKYEGTGLLMLEPTYKHILLEDVSEWNGLVLDDGLFLACESRIKQKVVARTNLSSAMLGNEGLFNLCLEGDGIAILESPVPRDELIEFILENDEVRIDGNFAIAWSKSLDFRVEKSSKSLVGSAVSGEGFVNVYRGTGKILMAPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I8X8</accession>
    <name>A0A174I8X8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266851.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82556">
        <property type="protein sequence ID" value="CUO82556"/>
        <property type="gene ID" value="ERS852471_02393"/>
    </dbReference>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="46"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO82556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="266" mass="29946" checksum="58947D13777486AF" modified="2016-09-07" version="1">MNKTIKQAVAPKTKAFGKEAFNKSEDTVIRWLGNAGVMINSRGTCIMIDPLLKGFDMPLLIDMPISVEEISHLDGILITHCDNDHFSRVTCRELSEVCNSYHGPHYVAELMREEGLKGIGHNIEETFKIGDMDITLTPADHAWQNESSKYSKIRKFNFEDYCGFWIETKDGTIWAPGDSRLLEEHLNMKNPDVIIFDFSNNSWHIGLEDAIKLANAYPDAKLILSHWGSVDAPEMDAFNADPAALIGKVINEDRIYIMAPGEAFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ILS4</accession>
    <name>A0A174ILS4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rpsC</name>
        <name evidence="12" type="ORF">ERS852471_02499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267040.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87086">
        <property type="protein sequence ID" value="CUO87086"/>
        <property type="gene ID" value="ERS852471_02499"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="222" mass="24371" checksum="98888E9DB825FAEA" modified="2016-09-07" version="1">MGQKVHPHGLRVGVIKGWDAKWYADKKTFADNLIEDNKIREFVKKELFSAGISKIEIERAAKRVKLNIYTAKPGVVIGKGGAGIEALKAKVAKLVNGKNILINIVEVKNAEANAQLVAENIAAQLEKRVSFRRAMKQSIQRAMKLGAKGVKTACSGRLGGAEIARTEQYHEGTIPLQTLRADIDYGFAEADTTYGKIGVKVWVYNGEVLPTKKVEKKEEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ILS7</accession>
    <name>A0A174ILS7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpsN</name>
        <name evidence="7" type="synonym">rpsZ</name>
        <name evidence="8" type="ORF">ERS852471_02506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117036.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87351">
        <property type="protein sequence ID" value="CUO87351"/>
        <property type="gene ID" value="ERS852471_02506"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO87351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="61" mass="7178" checksum="CA3A6850ADA64DD3" modified="2016-09-07" version="1">MARKAIIEKWSKTPKYTTRAYTRCRICGRPHAVLRKFGICRICFRELAYKGEIPGCRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IMK2</accession>
    <name>A0A174IMK2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="6 14">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ptsI</name>
        <name evidence="22" type="ORF">ERS852471_02534</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="6 14"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267085.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88573">
        <property type="protein sequence ID" value="CUO88573"/>
        <property type="gene ID" value="ERS852471_02534"/>
    </dbReference>
    <dbReference type="OrthoDB" id="467393at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="22" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="14 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="21">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="19">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="20">
        <location>
            <begin position="249"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="16">
        <location>
            <begin position="452"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="15">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00033235"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO88573.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="539" mass="59203" checksum="1A6DA256102C07D6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IW21</accession>
    <name>A0A174IW21_9CLOT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ERS852471_02599</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91593">
        <property type="protein sequence ID" value="CUO91593"/>
        <property type="gene ID" value="ERS852471_02599"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF4250"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14056">
        <property type="entry name" value="DUF4250"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="7372" checksum="59FB2B44BDE8DE06" modified="2016-09-07" version="1">MDRETILNMDPHMLVSILNLKLRDFYSSLDMFCDDMNIDKSELEDKLNKSGYFYQSGINQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J3K0</accession>
    <name>A0A174J3K0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yesO_2</name>
        <name evidence="2" type="ORF">ERS852471_02660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267313.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94332">
        <property type="protein sequence ID" value="CUO94332"/>
        <property type="gene ID" value="ERS852471_02660"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447734at2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024897" evidence="1">
        <location>
            <begin position="31"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO94332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="48587" checksum="2D23594CCA271634" modified="2016-09-07" version="1">MNKRILATILTATLGVGMFVGCGKKNNATAEIVKELNNPVSIEMWHYLNGKQAEVLDSIIQDFNSNNNMGITVTAVNQGNIGDLNKKVITASQSNSLPAIINVYPDIATGLINQNKIIDLSPYVNDSTVGMKSDIENDFYKTFIDEVSQWGKDAVYGIPMTKSTEVLYVNKTMLEKLGYTMDDLKDLTVEKLAEISKKCKDELGVVGFGFDSSSNAFISSLKMDGKDFVTIDGKINVDNDWVKTFMNYYKDEVGSGYFRIPGEDTYLSGPFSNQKLLMYQGSSAGAAHIKTDGAFEVGVVEVPVFQGKDKAVIQQGASLFVTSDVSPEAQFAAYEFIKYATNTENTAKFAVATGYLPVRKSAADTQIMKDALNDPEALFTKIYPVAQNSLEYAYYTPAVNNAQSARTIIQEKYDAYVSGSIKDIDTFIKDTTSQVETSIQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J3L3</accession>
    <name>A0A174J3L3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purP</name>
        <name evidence="8" type="ORF">ERS852471_02602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267207.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91700">
        <property type="protein sequence ID" value="CUO91700"/>
        <property type="gene ID" value="ERS852471_02602"/>
    </dbReference>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO91700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="431" mass="45354" checksum="AF1CDF48EC17310E" modified="2016-09-07" version="1">MDKFFKLKENNTNVRTEVVAGITTFMTMAYILIVNPSILSAAGMDQGAVFTATAVSAIIGTLIMGLYAKLPFAQAPGMGLNAFFAFTVVLGMGYSYQFALTAVLLEGLIFIVLTIFNVREAIVDSIPANIKKAISVGIGLFIALIGLEGAGVVVHPADGGTIVALGNITSGPGLLAIIGIVITGILVARKVKGALFLGMVITTIIGIPMGVTQMPSAIVSMPPSISSTFMQFEWHNIFSFDMVIVLFTLLFMDMFDTIGTLVGVATKAKMLDEDGKVPNIKKALFADAIGTTVGACLGTSTVSTFVESAAGVAEGGRTGLTAVSTAVMFGISLFFAPLFGMITPAVTASALVIVGLFMIETIKEINLEDYTEAVPAFLTIIMMPFAYSISDGIVFGVISYIALKLFSGKYRDISLTTVIVAIIFVLKFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J487</accession>
    <name>A0A174J487_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpP_3</name>
        <name evidence="5" type="synonym">clpP</name>
        <name evidence="11" type="ORF">ERS852471_02639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267273.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93481">
        <property type="protein sequence ID" value="CUO93481"/>
        <property type="gene ID" value="ERS852471_02639"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO93481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="22181" checksum="916BC41A1C1EDF1B" modified="2016-09-07" version="1">MSNYVPMVVEQTGRGERSYDIFSRLLKDRIVMLSGEVNDVTSNLIVAQLLFLESEDPDKDIYLYINSPGGSITAGMAIFDTMNYIKPDVSTICIGMAASMGAFLLSAGAPGKRFALPNSEVMIHQPLGGFQGQATDIDIHARRILKIKETLTRAMAESTNGKVDYETMVKMCERDNFMSAQEAKEIGLIDDVIVRNDIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J5A2</accession>
    <name>A0A174J5A2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type ATP synthase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntpC</name>
        <name evidence="4" type="ORF">ERS852471_02673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267340.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94912">
        <property type="protein sequence ID" value="CUO94912"/>
        <property type="gene ID" value="ERS852471_02673"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1532119at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO94912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="333" mass="38741" checksum="A3EDDF715460BB7F" modified="2016-09-07" version="1">MDVMQFTQALSRIWVFETRLLDRTKIERMIEAPSAEEALKILNETEYSNILSKAKRVNDYENILSYELKRVYELMYELCPVKDVVDLMSVKYRYHNLKVLLKGKFLSKDLSNLLIDLGIEDLKELKSIIDLDNFDDLKGYTKKAVIEVVKDFEENKDPQKIDIIVDRYMFDEMQDIKKKLDYKFTDKLVLATIDLTNIRTLIRLKKQGQGREFASKVLISGGAIDKDTLISIINETPENIITKLSTTIYSDIIKEGIENFKESNSASLLEKLSDNYIMDLMKGARLVTFGPDRILSYIYAKETEIKIIRIIMVGKLNNISQEVIRERLRDSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBY4</accession>
    <name>A0A174JBY4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">trmB</name>
        <name evidence="2" type="ORF">ERS852471_02718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267421.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97163">
        <property type="protein sequence ID" value="CUO97163"/>
        <property type="gene ID" value="ERS852471_02718"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO97163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="26077" checksum="BAA67AA843AD281E" modified="2016-09-07" version="1">MRMRRKPWARPELEACHFFIQKPSEYKGKWKEFFKNNNPIYLELGCGKGTFMAVHGSENPDINYIAVDIKDEVLVLAKRNIEKAYEEKNHKLNNVALMSQEIALIDDMLSEDDTVDRIYINFCNPWPKDRHKKRRLTHTRQLNKYKTFLKKEGEIWFKTDDDELFEESLEYFKECNLDIKYITYDLHNSGFEGNVVTEHEEMFTKQGIKTKFLIAEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JC18</accession>
    <name>A0A174JC18_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prmA_2</name>
        <name evidence="2" type="synonym">prmA</name>
        <name evidence="3" type="ORF">ERS852471_02720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267425.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97234">
        <property type="protein sequence ID" value="CUO97234"/>
        <property type="gene ID" value="ERS852471_02720"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="34835" checksum="A6A4F167E34B9DF6" modified="2016-09-07" version="1">MEGTWIEVRVITTSEALEPVSGIFYSLDCKGVAIEDPNDILGREQGPLTWDFADINILEHKGNAAVVKAYFSEEDNIEEVLKYIDERLSELKEMGINLGEGKLESEKVHEEDWANNWKKYYKPSKVGEKIVVKPIWEEYEEKDGELVVNLDPGMAFGTGTHETTRMCIQSLEKYVKEESVVFDVGCGSGILAIAAAKLGAKKAVGVDLDPVAVESSLENVQYNNLDNIEILHGNLVEVIEGKADVVVANILAEIICILTDDVKRVLKQNGYFITSGIIHDRVDMVVDKLEASGFEVIEKNRDGEWNCIVAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JJ73</accession>
    <name>A0A174JJ73_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">potB</name>
        <name evidence="7" type="ORF">ERS852471_02775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267518.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99794">
        <property type="protein sequence ID" value="CUO99794"/>
        <property type="gene ID" value="ERS852471_02775"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1488093at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO99794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="31857" checksum="339796C0E3BFF25B" modified="2016-09-07" version="1">MKKNNGKSILPAAPYIVWSSLFIVIPLLIVIFFSFTVSTSDGYKFSLENFQRLLDPNYFTVFKRSIWLALKATIGCLILGYPVAYLISKMRPGKRDMLIMLFIVPMWMNFLLRTYAWLPILGKNGIINNFLAFIGVGRINLLYNDFAVLLGMIYNFLPFMVLPIYTVLTKMDKDLINAASDLGANRVKVFTKIIFPLSMPGVISGITMVFMPAVSTFVISRLLGGGQYMLLGNLIEQQYTTMGDWNFGSAIAIFMMIIILISMGIMNLFESSDDKEGGGSMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JS32</accession>
    <name>A0A174JS32_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CapA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267526.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99970">
        <property type="protein sequence ID" value="CUO99970"/>
        <property type="gene ID" value="ERS852471_02779"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="4">
        <location>
            <begin position="78"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO99970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="439" mass="50208" checksum="14A7AAF45E8D9C80" modified="2016-09-07" version="1">MKSKIKMIYRSIFFVIVIGLIGIIIYKDINRSENKNIATYSDEATNYNSNETKDETIKFDEEIIKKDEIEDERIETIEIMAVGDLLMHIDIVQAMYDWSNDTYNFDYNFELIKDYLSKADLTIANLETTLAGEESGYSGYPCFNTPDELADSLKKSGVDIISNMSNHSLDKGEYGFIRTREVLKEKGFDVIGTRDSEKDSRYIIKEVKNIKVGITAYGYTTDAYEEARGLNGIPIPDNLYSLMNTFNPYDLDNDLLEMKKEIDKMKDDGVDVIVFYMHWGEEYQLEPNESQLTIAQFLANEGVDIIFGDHPHTIQPIDILESDDGNHSTAVIYSLGNFISSQRTESIGNPYTEDGLMVSVNITKNFKTGEVTVDVPQYIPTWVKLNIFNGNYCYQVVPATENEADYLDYYQTIRVDESFDRTFGIVESYNDSIEVWSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JU98</accession>
    <name>A0A174JU98_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OB-fold nucleic acid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267559.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00745">
        <property type="protein sequence ID" value="CUP00745"/>
        <property type="gene ID" value="ERS852471_02798"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="39896" checksum="60D93B5BE1DFA7D0" modified="2016-09-07" version="1">MGKKKSKNNIVFDQNKIRFYYGIPHCHSNYSTGRGTPTELYEYAAKCGLDYLFITDHNDFLNNKSSKDGSSTKWQSLISICNKFKKSHDDFLPVVGFECKTQSYGDFNVINSKNFFTGTLKDLRLLTLWMINNPTAFISINHPHKNIMDIPYDPIFNNIITSIEVCNGNPSAKITYHEKYFFQLLDCGWKLGAINGQDNHRVNFDESDNLTVYIGNELSKEALIDAFRMHRTYSTESRFLRLYFTINNNFMGESIVTNNKKLKFLIFAEDVKYRIKDIEIITNGGKLIKSINNINLNSIKYLYEHIPAENESWYVIKVYQSNGKIAITSPIFIYHYNIIDENTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JVF2</accession>
    <name>A0A174JVF2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 19" type="primary">uvrB</name>
        <name evidence="19" type="ORF">ERS852471_02828</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02611">
        <property type="protein sequence ID" value="CUP02611"/>
        <property type="gene ID" value="ERS852471_02828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="74"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="478"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="666"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUP02611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="704" mass="80629" checksum="BDC30724EB9A6B6B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K201</accession>
    <name>A0A174K201_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose/maltodextrin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">malX</name>
        <name evidence="2" type="ORF">ERS852471_02911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP06042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267772.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06042">
        <property type="protein sequence ID" value="CUP06042"/>
        <property type="gene ID" value="ERS852471_02911"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025707" evidence="1">
        <location>
            <begin position="25"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP06042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="441" mass="48144" checksum="B47C2BC3058BAF87" modified="2016-09-07" version="1">MKKLLVTLLVAATTLNLVACGSSNKGGQTSEGGTNETTGNDAKVELTVQVEEGWVPYYEQVKETVIGKYPNADIKFITTGSFDHLDVLDQSDPTNPDVADVFALPADRLYGLANNNALAAIDAETMANNVGGFKDFKGGLGGNFNVDGEYLAFPYNIETLIGYVNVANAEAAGIDFSKSIELTSVEADQILTTVHDCWFGVAFANSAELELLGHNDAGELYSDATKEWSELTEDQQKLFTALYDYWKFHDTNKTDLWDKEAAGGYIEEQFKTGGTDVIKIDGPWATTSVKDLVGDASNLEVIPLTNITVNGNPLTHWKGGWGLGVNARVEEDADKMAVAQAFIEEIVNPANAQELFKYTGKILENVEPSAYEGIDELEKKVIDATYAGYEKAENRPLFTEWGSVWDSWQNALLSWSSTQPKDAEAAYNEVKASFEAMMSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KAD9</accession>
    <name>A0A174KAD9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdhB_2</name>
        <name evidence="11" type="ORF">ERS852471_02946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267837.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07831">
        <property type="protein sequence ID" value="CUP07831"/>
        <property type="gene ID" value="ERS852471_02946"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1720141at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP07831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="23941" checksum="53D2DEC48F852BF5" modified="2016-09-07" version="1">MSNIGIFDVLGPIMIGPSSSHTAGAARLGKIAKTIVNKPIKDVTFLLHGSFKETYKGHGTDRALVAGILGMMPDDSRLKDSLLIAESEGLTIKFLPADLGQVHPNTVKFLITDLDDIQWEVLGSSIGGGLVEIYEINGNKVKITGEYPTIITSHDDIPGTISKISTIFYENEINIANMALVRSQKGQDATMTVEIDHTASDAVIEQIKSIDGVNRVIVINSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGI5</accession>
    <name>A0A174KGI5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267902.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09576">
        <property type="protein sequence ID" value="CUP09576"/>
        <property type="gene ID" value="ERS852471_02977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="62"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="30536" checksum="A9554722FB5363C0" modified="2016-09-07" version="1">MKKYFLISSILAVIMLIVGSIGLLATGEAFTGISFGNYGVKFNGVAESFTQEIDVVSSNIKFNLNVPNTKVEIYSGTNKRIIVNCWYNNENDKFTIDSNEDTINIKRKESYGTINLFDFSSIAGTVEIIVPESIIGNYTVESTNGNIEINDIKASNIDIETTNGNFEIGDITVEGEVKINTNNGRVVAEDINAESISFETTNGLVDIEDIKANDIRVRTTNGLIKAYNCYSKDIILRTTNGAITLENEDKNYQIENLDVNTTNGKETVNANYKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KK41</accession>
    <name>A0A174KK41_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267949.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10547">
        <property type="protein sequence ID" value="CUP10547"/>
        <property type="gene ID" value="ERS852471_03002"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942592at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="165" mass="19174" checksum="AE4E237D0F1413C7" modified="2016-09-07" version="1">MFKVNDYIMYGTTGVCKVIEIKKEKFLGKEEREYYVLEPVYSKNTVIKIPVDNTTIRMREILSKEAIEELINIVPNADTTWIEDDRIRNEQFKSMLKSGDCEELITLIRTIYLGKKTKKSIGKKLYKGDDEIMQAAEKLLNEELAFILDIAPEEVPNYIKEQVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLH7</accession>
    <name>A0A174KLH7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glcP</name>
        <name evidence="9" type="ORF">ERS852471_03049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268041.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12813">
        <property type="protein sequence ID" value="CUP12813"/>
        <property type="gene ID" value="ERS852471_03049"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="5"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="393" mass="42659" checksum="0CDF60CE7C5B1D31" modified="2016-09-07" version="1">MLTVLLVIIYIAFISLGLPDAILGSAWPTLHQDLGVPMSYAGVVTMIVAGGTIVSSFFSGKVIKKFGTGKVTTFSVFLTAAALLGIYFSPSFIWICILGIPLGLGAGAVDSALNNFVALRYEAKHMNWLHCFWGIGATAGPFIMSLYLLKENGWRLGYLTIGIIQAVLVICLFASLPLWKKFEVKDNDDEDTHVEVKVSTLIKLPGAKPALISFFCYCAIELTTGLWASSFLVVNNGLSAEKAAKWVSLYYLGITVGRFLSGFLAIKLNNKQMIRIGEVICIIGAVLLMMPFSNSLQLCGLILIGLGCAPIYPAMLHETPNRFGKELSQGIMGIQMATAYVGSTFVPPIFGFLSGVLGFNILPYFLMILMILMLATSERVSKVCRCSENIQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQN2</accession>
    <name>A0A174KQN2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gsiA_11</name>
        <name evidence="5" type="ORF">ERS852471_03035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268015.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12188">
        <property type="protein sequence ID" value="CUP12188"/>
        <property type="gene ID" value="ERS852471_03035"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP12188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="24067" checksum="E122B6E850AADC01" modified="2016-09-07" version="1">MLLEVKNVSYRYNKSSPWILEDVSFTIDSKERVALVGPSGYGKSTLAKIISGYIKPEKGEILWDGKPLPKNVYCPIQMIYQHPEKSVNPRWKMAKILNEAWEVDNNILQEMGIEKSWFNRWPNELSGGELQRFCIARVLGPETKFLVCDEISTMLDVITQAQIWNFLLKTSQENELGMLVVTHNIELANRVCDRIIELPKLNKKEEIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KUV4</accession>
    <name>A0A174KUV4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjjP</name>
        <name evidence="3" type="ORF">ERS852471_03108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15782">
        <property type="protein sequence ID" value="CUP15782"/>
        <property type="gene ID" value="ERS852471_03108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP15782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="252" mass="27114" checksum="9FA1BFB37A83DFBD" modified="2016-09-07" version="1">MNEILQVATFAGQMILENGGETYRVEETICRICKAFGAEEAESFATPTGIMASICHKGQTYSLIKRVSKRTVDLYKIDLVNDLSRNILTKNLSVKDFKSELQKINISERYSNNITLLFSALGAAGFAILFGGNMKDFLAAFIIGFIIKFITIKGSDMQINQFFINSLSAAVASFLAIILVKINLAANLDQTIIGSIMLLVPGLAITNAIRDTIAGDLLSGLTRAAEAFLVAISIAVGSGAVLSFWLSNIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L079</accession>
    <name>A0A174L079_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein ERS852471_03095</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_03095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268125.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15185">
        <property type="protein sequence ID" value="CUP15185"/>
        <property type="gene ID" value="ERS852471_03095"/>
    </dbReference>
    <dbReference type="OrthoDB" id="229299at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024560">
        <property type="entry name" value="UPF0313_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11842">
        <property type="entry name" value="DUF3362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="295"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP15185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="650" mass="74627" checksum="427D675D79EF0170" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L4R2</accession>
    <name>A0A174L4R2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccmK2_2</name>
        <name evidence="3" type="ORF">ERS852471_03178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268267.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19594">
        <property type="protein sequence ID" value="CUP19594"/>
        <property type="gene ID" value="ERS852471_03178"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP19594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="98" mass="10493" checksum="DA5D9FA92A9F7C4C" modified="2016-09-07" version="1">MNAIGIVEVVGVVASVEALDSMTKTSNVKFKTMEKKLGGRLVTIVVEGSVEDVQAAVEVGTRTADSITKCVAHAVIPRPHEEIMALLDRSSLKFNKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LFV9</accession>
    <name>A0A174LFV9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase class A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP20978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20978">
        <property type="protein sequence ID" value="CUP20978"/>
        <property type="gene ID" value="ERS852471_03202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="3">
        <location>
            <begin position="115"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP20978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="331" mass="38477" checksum="2D925ABAD5FBED38" modified="2016-09-07" version="1">MKIKRKHKRKISTLTILFTILLLSSFFIYSFLSSQNNISEVNSTIEDNISSRIISSNSPDSDSVTTLSISSLDYTSLSYSERLGILFNNNYLIDDRIKIYLGDEIDNIGLIYYNLENNTCININDNMEFIAASTYKVGLNLYAYYLNSIGQLDLNEYIEYLPEDYEEGTGILQYEYYIDSYSIQELLDLSLIYSDNIATNMLGRYLGGHEEVRKNLYNLLKIDFNSSENIITPAIEYKILKCIYEYSYYPNFKHMLSVLTQSEYNDRLTKYIDENIVAHKIGTYDTYIHDVGIVFDNSPYIIILYTHDLEDAEEKIANISNALYQYNNLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LSL9</accession>
    <name>A0A174LSL9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper-sensing transcriptional repressor CsoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csoR_5</name>
        <name evidence="1" type="ORF">ERS852471_03266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268424.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24489">
        <property type="protein sequence ID" value="CUP24489"/>
        <property type="gene ID" value="ERS852471_03266"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP24489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="119" mass="13295" checksum="732D379AF4D5DE31" modified="2016-09-07" version="1">MDSIEVLEHTHIGEDGHSFSHTHKNVEGHKHVHSHESTKDISNRLARAAGHLEFVRRMVKDERDCSEVLNQIAAVTSALNSVSRLILQGHIEECVTDAIQCGDKKVIEDLNKSLAKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LXJ2</accession>
    <name>A0A174LXJ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bmrR_3</name>
        <name evidence="2" type="ORF">ERS852471_03296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000040">
        <property type="protein sequence ID" value="CUP26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26410">
        <property type="protein sequence ID" value="CUP26410"/>
        <property type="gene ID" value="ERS852471_03296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="147" mass="17340" checksum="9C2C5345267E5E8C" modified="2016-09-07" version="1">MFSIGVFSKINKVTTKTLRYYEDVGLLKPGYVDEVTKYRYYTTEQLPKLHEIITLKQMGLSINEIKKVIDEPKEIENILVSKEKEILDIIKEEEYKLLRLRSYISNLKGDKGMKNIIMKSLPKVKVASMRRIVNSYNEFLEDNFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M6B6</accession>
    <name>A0A174M6B6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000050">
        <property type="protein sequence ID" value="CUP29309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29309">
        <property type="protein sequence ID" value="CUP29309"/>
        <property type="gene ID" value="ERS852471_03337"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637053at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="103"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP29309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="273" mass="31639" checksum="900D23B66F510611" modified="2016-09-07" version="1">MCTVLGVARSTYYKSFDKTKSTRELENEELKSAIKRIYKENKGIYGAPRIHYILGIEGFNVSLKRVQRRMSELGLYAITVKKYKPHSSKKVAEGLENVLKRDFTTTSINEKWVGDITYIHTIKDGWCYLASVLDLYSKKIIGYAFGKKMTNDLVVKALKNAYYSQSPDKNKQLIFHSDLGSQYTSNDLKKLCKEFNIIQSFSKKGCPYDNACIESFHSSIKKEEIYRNTYRTFEEANMAVFKYIEGWYNRKRLHSSINYMTPDQCELLARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGA7</accession>
    <name>A0A173XGA7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262708.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50330">
        <property type="protein sequence ID" value="CUN50330"/>
        <property type="gene ID" value="ERS852471_00029"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="252" mass="28423" checksum="F5207BCA918C2B3F" modified="2016-09-07" version="1">MILFFTGTGNSKYVAKAIANKINDEVVSLNNVIKYTMAKTFRSDKPFIIVAPIYAWRFPAIIEDLISKAEFIGNNEIYFIGTMESQSGNCYKYCKKICDKKGLIFKGFYGVKMPGNYVISKAMPDKDKVNEILNAANPVIEKLAEKIKNDENIEKDDKTPFSWLLSSAVNGAFNKFMVSSKNFVVSDRCITCGKCEKCCPVNNVKIRDGKPKFGDKCINCYSCIHHCPKEAINIKGKSENNGRYLCPEYNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIE0</accession>
    <name>A0A173XIE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ORF">ERS852471_00037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262724.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50796">
        <property type="protein sequence ID" value="CUN50796"/>
        <property type="gene ID" value="ERS852471_00037"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="162"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN50796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="335" mass="36204" checksum="C7B1DEFA540676E2" modified="2016-09-07" version="1">MDIITLSHGSGGRATNKLIKDLFYKHFTNEYLAQENDSTVLPKINGKLAVTTDSFVINPLFFKGGDIGKLSICGTVNDLAMSGAKPLYITVGFIIEEGLLISDLEKIVISMAETAKEAKVKIVTGDTKVVEKGSGDGIFINTTGIGVIEDSNLYIGGDKASAGDKIIISGTIGDHGIAIMNMRKNLDFDVQIKSDCGLLNGLIENILNTSKKVKVLRDPTRGGVATTLNEIAKHSLVSMEIDEDKLPIKEEVSSMCDILGLDPLFIANEGKLLVIAENEDAEKILNTMKKHPMAKDAAIIGEVVNDEKNRVYLKTEIGGKRIINMPEGELLVRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKP6</accession>
    <name>A0A173XKP6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murQ_1</name>
        <name evidence="3" type="synonym">murQ</name>
        <name evidence="6" type="ORF">ERS852471_00043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262728.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51205">
        <property type="protein sequence ID" value="CUN51205"/>
        <property type="gene ID" value="ERS852471_00043"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100044at2"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="56"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="244"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN51205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="32280" checksum="6204961AC3CB8D1C" modified="2016-09-07" version="1">MLNLENLTTEKMNTNTINLDKMTPFEIASVMNKEDENVIQAVRNSLVDISMAIEACTNALQKGGRIIYMGAGTSGRLGLMDAVECPPTFGVSHDLVIGLIAGGELAFIKAVEGAEDSKTLGEEDLKNINLNNDDIVIGLAASGRTPYVIYGLKYARKIGCKTACIVCNENSEMSKLSDISIELIVGPEVLTGSTRLKAGSAQKMVLNMISTGSMVGMGKVYKNLMVDLMQTNEKLIERSENIVMEATQADREVAKKTLQQARGKVKVAIVMILLHCNSKEAEEALNRAKGHIRKAIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLH7</accession>
    <name>A0A173XLH7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged helix family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">regX3_1</name>
        <name evidence="6" type="ORF">ERS852471_00069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262774.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52751">
        <property type="protein sequence ID" value="CUN52751"/>
        <property type="gene ID" value="ERS852471_00069"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="250"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="40770" checksum="5408054D6AA905A2" modified="2016-09-07" version="1">MLCGREFKRIRGEITNILKEITEHELFNNFIFYDEVPTEELQYWKYGISIIEEDFTASIQSVCGYFVASQKVMQNRECNINSFFRINDIIAEEFYYIDNINGPLNKLANSLKEIKSFAETVFGISIEINSGINNECQWLREVCDENMLIIHSAENEDFVDVSRMMSERYDLRCTKEKDNNKVELLRIPFDKVKYFDNFERIDNRNNYYEEERYNYINSNIEKEDNSEVKNITENDEDNGTTYEKLCELISGVWRYDNLRVDFTQKIITKEGERVRLGKKQMEILKILVYNKGNIISREQLIQYVWYTDEVNDRTVDAHISKIRRELGLTCIKSVPGYGYRLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNL7</accession>
    <name>A0A173XNL7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262801.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53481">
        <property type="protein sequence ID" value="CUN53481"/>
        <property type="gene ID" value="ERS852471_00085"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1731812at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="127" mass="14533" checksum="F7DAA9FFD2993368" modified="2016-09-07" version="1">MVSLVNEAYKIADSNNAILKGNIKISNNTNCLIFAHYCDSTLFYKKFYKISKDILKVNNIANKNLKEIKKLVKSYGYKKVWSKGVFSFYGDLRPLAVEAGFGKWSDSGIIENEKYGTNFMITAVFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNZ5</accession>
    <name>A0A173XNZ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">graR_1</name>
        <name evidence="11" type="ORF">ERS852471_00056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52148">
        <property type="protein sequence ID" value="CUN52148"/>
        <property type="gene ID" value="ERS852471_00056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN52148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="224" mass="26003" checksum="C26CA316DADC6158" modified="2016-09-07" version="1">MLKKILLIEDDLNVARELELSLVKWGFEVATIDDFENILKEFIDIKPSLILMDINLPYYDGFYWCEKIREISKVPIIFLSSRDSNMDIIMGMNNGGDDYITKPFSVDVLISKINALLRRSYDYASSDSLIYYNDAVLDIEKCIFRYKDKEIELTKNEIKILSLLIKNKGKVVAREKIMMSLWNDDEFVSDNTLTVNITRLRGKIKDLGLDDVIKTKKGIGYFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPN4</accession>
    <name>A0A173XPN4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III restriction protein, res subunit</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhlE_1</name>
        <name evidence="4" type="ORF">ERS852471_00079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53230">
        <property type="protein sequence ID" value="CUN53230"/>
        <property type="gene ID" value="ERS852471_00079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="384"/>
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            <end position="598"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN53230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="826" mass="96603" checksum="33A19086B5F1CC03" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XU58</accession>
    <name>A0A173XU58_9CLOT</name>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
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    </dbReference>
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        <property type="gene ID" value="ERS852471_00130"/>
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    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN55522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="182" mass="21016" checksum="C234C7CACD427D5A" modified="2016-09-07" version="1">MNKSIKLKHISGRIIDAKIRRLTNRDLDKILLLQDFIYESMVDKSLFAKTEKEEFENMINNKGEVIGVVTEDDELIAFGAMIKPKFKKFNLGYDLNYDDKKLISIAHIESTVVHSDYRGNRLQRTLVEELEKVAKDKGCCIFCATVAPQNEFSLNTFIKLGYKIAIEKEKYGGLKRYIVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YGZ7</accession>
    <name>A0A173YGZ7_9CLOT</name>
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        <submittedName>
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    <gene>
        <name evidence="9" type="primary">yloB_1</name>
        <name evidence="9" type="ORF">ERS852471_00243</name>
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        <name type="scientific">Clostridium disporicum</name>
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        <lineage>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">2789STDY5834856</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
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    </dbReference>
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            <end position="73"/>
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            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN63392.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="870" mass="94752" checksum="87BFB4DC0296C067" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVA6</accession>
    <name>A0A173YVA6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
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        </recommendedName>
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    <gene>
        <name evidence="7" type="primary">thiN</name>
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        <name type="scientific">Clostridium disporicum</name>
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        <lineage>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
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    </dbReference>
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        <property type="gene ID" value="ERS852471_00319"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPK_catalytic"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN67470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="23577" checksum="670CF7C6B6799891" modified="2016-09-07" version="1">MKALIVSGGERPSIELLKEIAAESELIIGADKGCDSLYDSKIIPKYIVGDFDSANIKKVNYLKEYGAIKLEFNPEKDFTDSDSALNLAIEEGANDIILLGVTGSRLDHTFGNLGLLISALNKNVKATIINENNKIFIVRNSVSLNKDIRYKYISFLSYGDVVKGLTIRNAKYNLKNYDLFIGDTMTVSNEFIDENIEVEFKSGKLLVIYSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z3D9</accession>
    <name>A0A173Z3D9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">ispG</name>
        <name evidence="5" type="ORF">ERS852471_00362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263330.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69956">
        <property type="protein sequence ID" value="CUN69956"/>
        <property type="gene ID" value="ERS852471_00362"/>
    </dbReference>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN69956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="349" mass="38151" checksum="DCE06E9E43E88F54" modified="2016-09-07" version="1">MERRITRKVKVGNVYVGGDAPVSIQSMTNTDTRDVEATLNQIRALHVAGCEIIRCAVPDMKAAESLKEICENSPMPVVADIHFDYRLALKSIENGVSAIRLNPGNIGNVERVKIVTEAAKEKNIPIRIGVNSGSLEKDILERDGRPTAKGLVESALRHVKILEELNFFDIVISIKSSDVPMMIEAYRLMSKECDYPLHLGVTESGTVFRGTIKSTLGIGTLLAEGIGDTIRVSLTSDPIEEIKVAKEMLIALGLRKQGMTFVSCPTCGRTQINLIKIAEEVEKRLENCDKNIKVAVMGCVVNGPGEAREADIGIAGGNGEGLIFKKGEIIKKVKEEDLIEELMKEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6G2</accession>
    <name>A0A173Z6G2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71259">
        <property type="protein sequence ID" value="CUN71259"/>
        <property type="gene ID" value="ERS852471_00386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="9242" checksum="EE1737355B793493" modified="2016-09-07" version="1">MEQKIMTFHDENGNKIDYQILEQKLINKTEYVTMAPVSNKADVEVFKIKFDKNWNETLVQVESEKELDMVRQVSSVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z702</accession>
    <name>A0A173Z702_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">accA</name>
        <name evidence="12" type="ORF">ERS852471_00381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263366.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70978">
        <property type="protein sequence ID" value="CUN70978"/>
        <property type="gene ID" value="ERS852471_00381"/>
    </dbReference>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN70978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="29624" checksum="CEA37C904E105C0A" modified="2016-09-07" version="1">MSKNIKAWSRVETARMIERPTTLQYIDIIFKDFIELHGDRAYKDDKAMVAGIAFLENEPVTVIGMQKGRDLKENIERNFGSPHPEGYRKALRFMKQAEKFNRPIICFINTAGAYCGVEAEKRGQGEAIARNLMEISKIKVPIISIIIGEGGSGGALALAVGDRVWMLENSVYSILSPEGFASILLKDATKSKEVAENMGITSYELLERNIIEKVIKEPKGGAHNDIESVAKNIKVELIKELEVLKSKTINALLDERYKRFRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7P3</accession>
    <name>A0A173Z7P3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71218">
        <property type="protein sequence ID" value="CUN71218"/>
        <property type="gene ID" value="ERS852471_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="65"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="33283" checksum="2373286BA826C63C" modified="2016-09-07" version="1">MNDKKLKNSYDKAMKKHKGNKKAQLITTVIFAIIALVTIAFGGELKNTTTGAIGTMKVHYIDVGQGDATLVQVNGKNLLIDAGPNKSADSLVEYIKGIGVTTIDHVIATHPHEDHIGGIDEIFDAFEVKNFYSPKVEHTTKTFEKMINAVTNEGLKITTIKAGDGSKIDLGDGTKVEIFSPVDDKYNELNDYSPIMKITFGENSFLFTGDAEKLVEKQVIANGENIDADVLKVGHHGSTTSSSEDFIKEVSPDIAVIPVGEGNDYGHPHKEILELLEKNNINLLRTDFEGTIILESDGENIKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8L4</accession>
    <name>A0A173Z8L4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
            <ecNumber evidence="2">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argE</name>
        <name evidence="2" type="ORF">ERS852471_00402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263401.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72133">
        <property type="protein sequence ID" value="CUN72133"/>
        <property type="gene ID" value="ERS852471_00402"/>
    </dbReference>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017706">
        <property type="entry name" value="Peptidase_M20/DapE_YgeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03526">
        <property type="entry name" value="selenium_YgeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="400" mass="44846" checksum="A4128EFC0FD3AFB8" modified="2016-09-07" version="1">MDFNKIKERAKSYESKMTRFLRDLIAIPGESSEEEGVIKRIAEEMRSLEFDKVEIDKMGNVLGYMGTGKTLIAYDAHIDTVGLGELSNWTFDPYEGYETESEIGGRGASDQLGGIVSATYGAKIMKDLGLLSDKYTVLVTGTVQEEDCDGLCWQYIYNESEIKPEFVVITEPTNGNIYRGQRGRMEIRVEVKGVSCHGSAPERGDNAIYKMADILQEIRVLNDNLHYDPFLGKGTITVSQIFYNSPSRCAVADMCAISLDRRLTDGETYEMALEEVRNLPFAKKYNAEVTMYKYERPSWTGLIYPTDCYFPTWVIPEEAPATQAMVKAYEGMYGTPKVDKWTFSTNGVSIMGRYGIPCIGFGPGKEEEAHAPNEKTWKADLVKCAAVYAAVPTLYCEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZA42</accession>
    <name>A0A173ZA42_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ion transport 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263423.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72673">
        <property type="protein sequence ID" value="CUN72673"/>
        <property type="gene ID" value="ERS852471_00416"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1006680at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="396" mass="46380" checksum="07B9041B9BA81EDF" modified="2016-09-07" version="1">MSYVNFKEERQVTREQLKKRRKNNEEIFNKLIETKDLPKIYIPDNEYSYKKFEDKHFGIGRIKDEEDYEKINDKDIVCTIFENCTFGNIKFENCNFIGCIFKKCKFESGGVIFKNCSFYKEESEKKPSLNRRDNFSCEFSNCEIYAKFDGSTIAYCIFSSCFISNTYFLLSDMTSLIIIDSELKRIRIEDCDLSGAKIMSTYIIDLDFTDKIKSKLDEKTFFDKIKLREKDRNEYEGVYMTYETIGDKFKENNLNNNFGEYYYLCKLTQRKTLKIFPRINSFLYWATCGYGERPIYSIIFALATILIFAILYLIFGIKIDDNMISYLNYKIYSNDLTYHLLNIHKAITLSCGMFSGVGSSSIEPIRFSEFLGNVEMLVGLIIIGIGVGTVTRKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAX9</accession>
    <name>A0A173ZAX9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72345">
        <property type="protein sequence ID" value="CUN72345"/>
        <property type="gene ID" value="ERS852471_00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN72345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="48" mass="5638" checksum="B02BC761EFB4488A" modified="2016-09-07" version="1">MNSKNNEEVICPICGEIMDKYPYAYDNNQYGKLYYKCDVCGHKEVKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVB0</accession>
    <name>A0A173ZVB0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rnjA_2</name>
        <name evidence="9" type="synonym">rnj</name>
        <name evidence="12" type="ORF">ERS852471_00510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263613.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80392">
        <property type="protein sequence ID" value="CUN80392"/>
        <property type="gene ID" value="ERS852471_00510"/>
    </dbReference>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="361"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="552" mass="61530" checksum="648A3F8D2E8C9004" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZW63</accession>
    <name>A0A173ZW63_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coenzyme A disulfide reductase</fullName>
            <ecNumber evidence="4">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nox_1</name>
        <name evidence="4" type="ORF">ERS852471_00512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263617.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80511">
        <property type="protein sequence ID" value="CUN80511"/>
        <property type="gene ID" value="ERS852471_00512"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="331"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="48778" checksum="1C19C3F1853E731A" modified="2016-09-07" version="1">MKVVIIGGIAAGMSAAAKFKRLCPNDEVIVYEKGDIVSFGACGLPYYVGGFFEDSNEMIARTPEKFRESGVDIFTKHEVLGIDFDSKTLKVKNIRDNEEFTDSYDKLMIATGARAIIPPIKNVNLENVLTLKSMEDGNRIKALLSNPDLKKVTIIGAGFIGLEAVEAAKQKGKEVTVVQLQDRVLAEVFDKEITDLLEEEIRSHEVNLLLNETVLELGGDTKVNKVITNKGEFETDLVILATGVRPNTEFITDQRIEKLRNGAIVVDKFGRTSIEDVYAAGDCATINNYVSEKEAYVPLATGANKLGRIVGENLAGQNNCFQGSLASSCIKVMNMEAARTGLSEKEVKELGFDYKTKFISDMNQTSYYPGRQKIYVKLIYDAHSKVILGGQVAGYKDAVQRCNVLAACIFGKMTTEQLGMLDLCYAPPFARTWDVLNVAGNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A426</accession>
    <name>A0A174A426_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263667.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82659">
        <property type="protein sequence ID" value="CUN82659"/>
        <property type="gene ID" value="ERS852471_00542"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="163"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="404" mass="46674" checksum="81989AE90F38B9D6" modified="2016-09-07" version="1">MKDYILDNGLKLVYKKGNSELSSIAISLDAGAARDGENLGVAHVTEHMVYKQTETRSEKEINKVLSDTFGFQNAMTNYPYVVFYGTLLNEDLSKGLEILSDILLNPVFTEEGFKEEMEVIKQELKEWDEELEQYTEDKLYLNCMDGRRLQYPIIGTEESLERLTIDDAIDFFNDYYCANNATITVISSLEFDEVVDKVEEYFIDWRSESLPEDEIIYSTPNTGVFIDKKDDINSAKVQIIFPINELNQWEIKALKVFNQYFGEGVNSVLFDSLRTTNGLVYDVLTRVANEEYIKVYKITYGTAVENIEKSIKIVENLISNVDNLKKELNTENIAKMIKSFKLKRLFGEEQTVRLAKELATYDTMFGDYNIYLDESRDLEKLTPEYIINTAIKVLRNMSIQVIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AE65</accession>
    <name>A0A174AE65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Restriction endonuclease S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263771.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86961">
        <property type="protein sequence ID" value="CUN86961"/>
        <property type="gene ID" value="ERS852471_00598"/>
    </dbReference>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="184"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN86961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="375" mass="42793" checksum="1BB931FF0305F761" modified="2016-09-07" version="1">MEYIKIKDLFKITKGKKVEQVEERTDSSIRFIQIDDLRNDINLKYCENDKKYVIVNKEDIIIAWDGANAGTIGFGLEGAIGSTLAKLTKDNNEMDTEFCGLFLRSKSAYLREKCTGATIPHIQRESLEELEIPKLPLEIQKKIKNIINKAQELIDKRKEQIEALDELVKSQFIEMFGDPVTNSKGWEKEKLNELGELARGKSKHRPRNAPELLGGPYPLVQTGDIANAGIYLKEYTQTYSEFGLKQSKMWDKGTLCITIAANIAKTSILTFDACFPDSVVAFIPNEKTNNMFIQFWMSFLQKILEDSAPESAQKNINLKILSEQKVIVPPIELQNQFADFVEQVDKLKLEMEKSLNELEDNFNSLMQKAFKGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AG23</accession>
    <name>A0A174AG23_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PD-(D/E)XK nuclease family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86859">
        <property type="protein sequence ID" value="CUN86859"/>
        <property type="gene ID" value="ERS852471_00596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="33484" checksum="B65E409CCC6B4412" modified="2016-09-07" version="1">MRKIKPLNDFIFKKVFGEKGNEDILISFINAVLKRTNKEPIIEIEIIDNKQLTKEVINDKTGIIDVRARTAKGENIDIEVQLTDQGNMDKRTLFYWGKMYLENIKQGDDYTKLEKVITINILDFDYLNTEGYQSSFHLWEDIEKDYMLTDMVEIHFLELPKFRRKQNKNYKDNAIERWLAFLEKDIPETTLRELMNLEPAIEKAEKRIEYLSSDEDTMSIYWERERSLHERANMINTAEARGSMKEKIKNAISLLDILDDETISEKIGLDIDEVKKLREDNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATD9</accession>
    <name>A0A174ATD9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NagC/XylR family transcriptional regulators</fullName>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xylR</name>
        <name evidence="1" type="ORF">ERS852471_00672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263902.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91777">
        <property type="protein sequence ID" value="CUN91777"/>
        <property type="gene ID" value="ERS852471_00672"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047700">
        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN91777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="32662" checksum="697C2052CBD7717F" modified="2016-09-07" version="1">MRKIISIDVGGTFIKYGLVDEAGNVLCKNKMETIQKTAEGFVNELCEIANLYKEHKDILGIAISMPGFINNIEGIPLVCSVLRFIEGYKLQEELSLRTNLKVRIENDANCVALAEKFSGNAKECEDFICITIGTGIGGGIYLNNKLIRGKQFKGGEFCYMITKDKAGYQKLNENSSMTALIKMYKEYKKISDTEKVLGSDIFKEAEKDENIKAIINEWYGNIARMIYNVSSMLNPEKILIGGGVSAREELISELQNALNEIPWWKHVSCTIEKCKHENDAGLIGAAYNFINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATK8</accession>
    <name>A0A174ATK8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_3</name>
        <name evidence="7" type="ORF">ERS852471_00674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263906.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91874">
        <property type="protein sequence ID" value="CUN91874"/>
        <property type="gene ID" value="ERS852471_00674"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN91874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="278" mass="30969" checksum="1466DF57B39F3EB2" modified="2016-09-07" version="1">MLQNKENKIIKICMYACAILWAIFSVAPLIFTLMSSFKDTNDIYSNSFALPETISFFNYETALGKADIVSAIFNSFFLAISTTILVVILTTLVAYVITRTGFKLRNLLLTYFVIGLTIPMHTTLIPIADIINRYGFKNQLIPLIFLYATFQLPFAIFMMSGYMRGISKEIDEAAIIDGCGRLRLVFGILLPLAKPAAATISIFTFMSVYNEFIFGLMFLTDKTKYTISVALMSLNGRYSSDKGAIFAAISMFIIPIIIIYVLCQKHVEKGITSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B793</accession>
    <name>A0A174B793_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KWG repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96697">
        <property type="protein sequence ID" value="CUN96697"/>
        <property type="gene ID" value="ERS852471_00726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="407"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="513"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN96697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="603" mass="69137" checksum="5D6C12CB8C1A79F7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B8Z6</accession>
    <name>A0A174B8Z6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264020.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96913">
        <property type="protein sequence ID" value="CUN96913"/>
        <property type="gene ID" value="ERS852471_00730"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669763at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN96913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="191" mass="21847" checksum="5AD420CA6B7991C6" modified="2016-09-07" version="1">MGKKIELVYEDKKYIVSIDGSEVEKLEDVDKAFERFKQVIKNNDSNNDKSWLYIEETIKSFENENVEINGQFKTVTIGPLKYFYNTGKVFYISESDMTQLIGGYGLIKFILETPGLQEKENIESFLELCKVAVENGANYRLSGGSITIISAVLNYGSVEFNFNYNKINKGIAIEDGSFEEFKKYVLETINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGJ0</accession>
    <name>A0A174BGJ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iscS_2</name>
        <name evidence="5" type="ORF">ERS852471_00775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264107.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99309">
        <property type="protein sequence ID" value="CUN99309"/>
        <property type="gene ID" value="ERS852471_00775"/>
    </dbReference>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="3"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN99309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="381" mass="42860" checksum="1A5E7BA1B1E3BFA4" modified="2016-09-07" version="1">MDIYFDNSATTKPYEEVIKAVADGMREYFGNPSSLHKIGIKCEKRLTQCREYISSTIKCDKDEIYFTSGGSEGNNFILKGLLKPGHHFITTSFEHGSIMNTCKELEDKGVKITYLDVDQYGNISLEDLEEAITKDTVLVSIMYVNNEMGAIQNIEEIGKLIKEKSNRARLHVDAVQAYGKFDIDVKKMNIDFLTVAGHKIHGPKGVGFCYIKKGIVLNPLVSGGEQEKGLRAGTVDLPSIIGLEKAAQITFAHKDETYKKVYELKKYMIERLKEIEDIRINSPLEGNFSPYILNVSFRGVRSEVLLHLLEDQNIYVATGSACSSKVSMSKGSYVIKALGLNAKEIESAIRFSFSYENTKEEVDKTIEVLKGSLMFLRRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUK2</accession>
    <name>A0A174BUK2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264286.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04307">
        <property type="protein sequence ID" value="CUO04307"/>
        <property type="gene ID" value="ERS852471_00870"/>
    </dbReference>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO04307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="301" mass="35022" checksum="BBF02FF97A847C38" modified="2016-09-07" version="1">MIWISIIIILILVVLSLGVNIGLKETVMSKRKESRQMLEELWSRFGTDYRNYQNIPVEEVIIKSYDGLKLKGYFHRVYKDSKKVVIMNHGYTANHYIDYQFTDIFFEEGYNVLLIDMRSHGESEGKVASYGYNESKDIGSWVRWIKDKIGEDAYIGLHGQSMGAATVMLYGATHPNDIKFVIEDCGFTSAREAIKFQFRKVKIPFWPLYDLIRVKVKRKYKFDFNNISPEDAIVNSDIPVLFIHGDNDKVVPTWMGEALYNEKNGEMDRLYLVQGAGHMEAYSKDKEKYKQVVKEFLDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C659</accession>
    <name>A0A174C659_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-54 factor interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pspF</name>
        <name evidence="3" type="ORF">ERS852471_00902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264366.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07380">
        <property type="protein sequence ID" value="CUO07380"/>
        <property type="gene ID" value="ERS852471_00902"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="78"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="2">
        <location>
            <begin position="428"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="528" mass="60272" checksum="E72E0DC53F421078" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7H7</accession>
    <name>A0A174C7H7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exoaminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ysdC_3</name>
        <name evidence="8" type="ORF">ERS852471_00907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264376.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07656">
        <property type="protein sequence ID" value="CUO07656"/>
        <property type="gene ID" value="ERS852471_00907"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="356" mass="39059" checksum="119DEB5B38552660" modified="2016-09-07" version="1">MITNKTLELMRELTQVIAVSGNEIKISKILQNYYGKYTDEIVYDNLGSVYGVKKSKKPNAPKVMISSHMDEVGFIIKDFTKNGLIKVLSLGPACKQGLLGQRVRVMTNDGEEYKGTIVAKSNSDKDKVLDADKILIDIGASSIEDFSSLGIRLGDSIVIDGSFEVLATGKRIMSKAWNSRYGCALGVEILEALKDVELDVDLYVGCTVQHEVGLRGSQTATNLISPDLAIVLDCLTADDISGDSDAVGKLGEGVLINFYDKSMMPNRALLNHLMTICKNNGIPNQFYYSMCDGDGGWIHKLLRGCPTLNACICARNVENNSSIIDVNDYLAARESVTKVVKSLNTEMIEMFRTENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBE3</accession>
    <name>A0A174CBE3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron-sulfur cluster-binding protein</fullName>
            <ecNumber evidence="9">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">queG</name>
        <name evidence="9" type="ORF">ERS852471_00958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264475.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10333">
        <property type="protein sequence ID" value="CUO10333"/>
        <property type="gene ID" value="ERS852471_00958"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO10333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="328" mass="37988" checksum="CCF127F19C99BC8D" modified="2016-09-07" version="1">MIKEKIVKYCNSIGLDTIGFVKCRVFEELREFYLDRKEKGLENEFEENDIEKRINPNVYMEDGKTIISIAFPYYMGKEDVDNGFSVYTKGYDYHRVVKSYLDKICTYINELGGKAIPLVDSNSLPERYIGFLAGLGIIGKNNMIITKKYGSYVFLGEIITDLEICCRDAGTFEDIQKYDGCNECKVCIDNCPTKAIMTGRKNPNICSSYITQKKELSKIDYKLIKNRIFGCDICQNTCPYNKEISFSNLEEFKSLDFMNTTDIKYYADLNNKEFKEKISRTSCGWRGKNVIRRNAIIRLHNEGEDIEKYKGDSLMINNCIDEIKRINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIL1</accession>
    <name>A0A174CIL1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-1,6-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
            <ecNumber evidence="4">4.1.2.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fba</name>
        <name evidence="4" type="ORF">ERS852471_00994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EC" id="4.1.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264528.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12019">
        <property type="protein sequence ID" value="CUO12019"/>
        <property type="gene ID" value="ERS852471_00994"/>
    </dbReference>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047441">
        <property type="term" value="F:5-dehydro-2-deoxyphosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="287" mass="30515" checksum="6F1697AA9D511EC3" modified="2016-09-07" version="1">MLVSAKEMLNKAREGKYAVGQFNINNLEWTKAILLTAQENNSPVILGVSEGAGKYMCGYKTIVGMVNGMLEELNITVPVALHLDHGSYEGCYAAMNAGFSSVMFDGSHYSIEENIAKTSELVKATAEKGLSLEAEVGSIGGEEDGVVGKGEVADAQECKSIADLGVTMLAAGIGNIHGKYPSNWQGLAFDALEEINNACGNMPLVLHGGTGIPEEMIKKAISLGVSKINVNTECQLAFQEATRAYVEAGKDKEGKGFDPRKLLNPGFEAIKATVKEKMELFGSVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPQ5</accession>
    <name>A0A174CPQ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CBS/transporter domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ERS852471_01034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264570.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15521">
        <property type="protein sequence ID" value="CUO15521"/>
        <property type="gene ID" value="ERS852471_01034"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="286"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO15521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="431" mass="47633" checksum="B3328FBBAF4CC05D" modified="2016-09-07" version="1">MDGSPSGNFILIFILVMVNAFFASAEMAIVSINKTKITLLAEDGDKKAKLLLGLLKEPSNFLATIQVGITFAGFFASASAATSISSGLAYFLSSLGVPYSSNIAVLLITLLISYITLVLGELLPKRIALQNAEKVAMFTVKPIIFISKLTKPFVWFLSASTNLLLKILGIKTDGIEENVSREEIKSLIELGEEQGALNETERNMIDGIIQFDDILAKEVMTPRTETFCLEVKSSIKDNINTILEESYSRIPIYDDDIDNIVGILYMKDIFSNVVNKGIENLSIESIMRKPYMVPETKNIDDLLKELKSTKNHMAILIDEYGGFSGIVTLEDLIEEVIGEISDEYDDNSSKIKKLDDKNYIVDGLVTISDVNKYLSLNLESEIIDTVGGLVLENLGVIPNGYINKEITINSIIFKILSLDNKRIDKVQITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVD7</accession>
    <name>A0A174CVD7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264571.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15576">
        <property type="protein sequence ID" value="CUO15576"/>
        <property type="gene ID" value="ERS852471_01035"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1208786at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009706">
        <property type="entry name" value="DUF1287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06940">
        <property type="entry name" value="DUF1287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="233" mass="26907" checksum="52F3A716A2AA3A2C" modified="2016-09-07" version="1">MGFNLKIKSIIKYFIIIIVFIILVGIVVALDFFNLLPQQSYTADDFDIETILSDTDYNGNGIDDYTDIVIGARIDAKNKPKYHSAYYDGGYPPNEEGVCTDVIWRAFRNAGYSLKDMVDKDIEENVDLYPRVEVTPDKNIDFRRVPNLKVFFDRYAEALTLDPYDIEEWQPGDIVIFGEQYVHIAIISDKRNKDGVPYIIHNGGQPVREENMLVKYTIWQPITGHYRFKGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYV5</accession>
    <name>A0A174CYV5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alginate O-acetylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">algI</name>
        <name evidence="11" type="ORF">ERS852471_01096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18691">
        <property type="protein sequence ID" value="CUO18691"/>
        <property type="gene ID" value="ERS852471_01096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="36487" checksum="99392734F35CB14A" modified="2016-09-07" version="1">MVFSSLIFIFIFLPLVLVSYYIAPKRLRNTIILLASLIFYAWGEPVYILLIMVSILINYIGALLIGKYISDKEKSKFIFITLLLIDISILFFFKYYGFAIESLGSILGLNLQIKNIALPLGISFYTFQQVSYIADVYMQKTKPQRNLIDFAAYITMFPQLIAGPIVKYNDVYKQLDNRKESINEFGEGVQRFIVGLGKKVILANNIGLIWSQVKEIPLNDLSVVLSWIGIIAFTLQIYFDFSGYSDMAIGLAKMFGFDFLENFDYPYISKSITEFWRRWHMSLGGWFREYIYIPLGGNKKGALIQVRNLFIVWFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0N3</accession>
    <name>A0A174D0N3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="5">2.7.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfkB</name>
        <name evidence="7" type="ORF">ERS852471_01100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:58695"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.144"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14213"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.56"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbohydrate kinase PfkB family. LacC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264620.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18867">
        <property type="protein sequence ID" value="CUO18867"/>
        <property type="gene ID" value="ERS852471_01100"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1323781at2"/>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005988">
        <property type="term" value="P:lactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO18867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="301" mass="32664" checksum="485D2BFB67F96F1C" modified="2016-09-07" version="1">MIYTITFNPALDYIVKMDEFNLGHVNRTTREDVYAGGKGINVSIVLNNLGVDNKALGFIAGFTGDEIERRVKEFGCSTDFVKLKSGMSRINVKMKADVESEINGGGPDISEEALEELYSKLEKLQSGDILVLAGSIPKTLPVDIYERIMDHFGNRGIKFIVDTTGESLLKVLKYKPFLIKPNHHELAELFNVKLNGQDDIIAYGKKLQEMGAENVLISMAGDGAILIKSNGEAVYSNVPKGVLKNSVGAGDSMVAGFIAGYIKNEKLEDGFKMGVATGSASAFSEGLATKDKVEELLAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2C9</accession>
    <name>A0A174D2C9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19872">
        <property type="protein sequence ID" value="CUO19872"/>
        <property type="gene ID" value="ERS852471_01119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="53" mass="6078" checksum="9A2258652E261D37" modified="2016-09-07" version="1">MNKYANQSKQQGQQNSMQSNAMGNQNQGQMQSSAQIDQNIENYKKQQQKNSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2U2</accession>
    <name>A0A174D2U2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">uppP</name>
        <name evidence="15" type="ORF">ERS852471_01117</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264637.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19773">
        <property type="protein sequence ID" value="CUO19773"/>
        <property type="gene ID" value="ERS852471_01117"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO19773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="30870" checksum="6D0B4C9C17D702D3" modified="2016-09-07" version="1">MEFLEIIKAIILGIVEGITEWLPVSSTGHMILVDEFLKLNVSPEFMEMFLVVIQLGAIMAVVILYWKKIFPFTFDKKGMHIEKETFSMWFKIIVACLPAAVVGLLFDDYLNALFYNPTTVAIMLILFGILFIVVENYNKGKRPTINSLADITYTTAIIIGIWQLIAAVFPGTSRSGATIVGALLIGVSRTVAAEFTFFLAIPVMFGASALKLLKFGFSFTGNELMLLVVGLVVAFVVSVLAIKFLMTYIKKHDFKVFGWYRIVLGIIVLAYFYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8B0</accession>
    <name>A0A174D8B0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20509">
        <property type="protein sequence ID" value="CUO20509"/>
        <property type="gene ID" value="ERS852471_01134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045751">
        <property type="entry name" value="DUF6179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19677">
        <property type="entry name" value="DUF6179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="406" mass="47547" checksum="89F2D7F8D85F4F48" modified="2016-09-07" version="1">MENNNSLLKFSDEIQLENNISNENRELIEIKMWNLLGKWTERYTMGDSTSVPIEIAEELLKSISFSIGIELRDSSDFVERLINDDMMKLLKESWAKIEAMIDEGKVLLKEVIETSIHIGNISYEDTIREIEQFFKRYDYRFFAHQIDCSIDYQLSNPISEELQGIEYINKYLKTILIENKFCSKFSRENIINILNSHCSDYKGLLINIFEPVVINTLGLSILEEDILGLDISKFQRERLLLFFKGLSKKQTKEALADGAKKVCDKLNIKSNEVIEYIKKTCIDIYPRLEEALAEGNIENIFLSFEIQDDFIENVFIDNEPMNDEKLRDLIDEIKSCRFISDKIAIVKQEIHSLEDLIEVLGQCFWGDEPIELFKALSKDEIELIRYYLENNPEYYSDSGWEKKCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFF6</accession>
    <name>A0A174DFF6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione biosynthesis bifunctional protein GshAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Gamma-GCS-GS</fullName>
            <shortName evidence="10">GCS-GS</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate--cysteine ligase</fullName>
                <ecNumber evidence="10">6.3.2.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Gamma-ECS</fullName>
                <shortName evidence="10">GCS</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Gamma-glutamylcysteine synthetase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutathione synthetase</fullName>
                <ecNumber evidence="10">6.3.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">GSH synthetase</fullName>
                <shortName evidence="10">GS</shortName>
                <shortName evidence="10">GSH-S</shortName>
                <shortName evidence="10">GSHase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Glutathione synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gshAB</name>
        <name evidence="10" type="synonym">gshF</name>
        <name evidence="13" type="ORF">ERS852471_01185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="10"/>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264698.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22898">
        <property type="protein sequence ID" value="CUO22898"/>
        <property type="gene ID" value="ERS852471_01185"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250578at2"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00782">
        <property type="entry name" value="Glut_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007370">
        <property type="entry name" value="Glu_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006335">
        <property type="entry name" value="Glut_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006334">
        <property type="entry name" value="Glut_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040657">
        <property type="entry name" value="GshAB_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38761">
        <property type="entry name" value="PTHR38761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18419">
        <property type="entry name" value="ATP-grasp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04262">
        <property type="entry name" value="Glu_cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01435">
        <property type="entry name" value="glu_cys_lig_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="510"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate--cysteine ligase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO22898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="773" mass="89257" checksum="28B922543E97D99C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNR8</accession>
    <name>A0A174DNR8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264739.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25939">
        <property type="protein sequence ID" value="CUO25939"/>
        <property type="gene ID" value="ERS852471_01220"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1472689at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO25939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="578" mass="64637" checksum="0DE9A136F533800B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTI4</accession>
    <name>A0A174DTI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase, molybdenum-binding subunit</fullName>
            <ecNumber evidence="2">1.2.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mop</name>
        <name evidence="2" type="ORF">ERS852471_01251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.99.7" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264787.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27436">
        <property type="protein sequence ID" value="CUO27436"/>
        <property type="gene ID" value="ERS852471_01251"/>
    </dbReference>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033727">
        <property type="term" value="F:aldehyde dehydrogenase (FAD-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="709" mass="78841" checksum="24F902957394D5A0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EC79</accession>
    <name>A0A174EC79_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">purA</name>
        <name evidence="11" type="ORF">ERS852471_01380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265025.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34216">
        <property type="protein sequence ID" value="CUO34216"/>
        <property type="gene ID" value="ERS852471_01380"/>
    </dbReference>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
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        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
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        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
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    </dbReference>
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    </dbReference>
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            <end position="16"/>
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            <end position="41"/>
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            <begin position="300"/>
            <end position="306"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="8">
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            <position position="13"/>
        </location>
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        <location>
            <begin position="12"/>
            <end position="18"/>
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        <location>
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            <note>ligand shared between dimeric partners</note>
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        <ligand>
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            <end position="334"/>
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        <ligand>
            <name>GTP</name>
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            <dbReference type="RuleBase" id="RU000520"/>
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        <source>
            <dbReference type="EMBL" id="CUO34216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
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    </evidence>
    <sequence length="428" mass="47847" checksum="7CA8598BFC001431" modified="2016-09-07" version="1">MSTFIVLGAQWGDEGKGKMTDYLAEEAEVVVRFQGGNNAGHTVEVGEKQYKLHLIPSGILHDEKLNVIGNGVVVDPIALFSEIDYLEREGVKVTPEKLIVSDRAHVIMPYHKTLDKLKEKARGKNDIGTTGKGIGPCYTDKFERCGIRICDLIDKEVFKEKLENNIKLKNDYITNILGGEPLNFDEIYNEYVEYAERLKPFVQDTSVRIYDDIKKDKTVLFEGAQGMLLDIDYGTYPFVTSSNTTAGGVASGVGIGPNMITNAVGIAKAYTTRVGKGPFPTELENETGEWIREKGHEYGVTTGRSRRCGWLDIVILKTSVRVSGLTSLAVTKIDTLAGLDKVMMCVGYKFNDKVIDYFPASLEDLAKCEPIYEEFEGWDESVADARSYEELHPNARKYLERIEELTDTRISIVSVGPRRDQTMRVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHS4</accession>
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        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
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        <name evidence="2" type="primary">degV_2</name>
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        <name type="scientific">Clostridium disporicum</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35989.1"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="DegV"/>
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        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO35989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="30844" checksum="A574F3605C2E7DD2" modified="2016-09-07" version="1">MQKIALITDSGSDLSLEELREYNVNLLPLRISYSTGEYQDKIDIKASDVYANLDKEVPKTSLPSPETTEKILTKLEEEGYTHVIAICISGGLSGTANSLRLSLEDHPNLTSYVYDTKILAYPEGEIVIEVSKLIKSGKTFEEIIEALPKIREKITGYFTIDTLEYLKKGGRIGRVAGTLGEMLNLKPIITTDENGVYYNIVKARGRKQALSKLTDILKTHLAKNKCDVTVLQGGCEAEAIKYMESLKGLDNINSLKLSEISPALGVHGGPGLMGFCVKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EL69</accession>
    <name>A0A174EL69_9CLOT</name>
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        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter</fullName>
        </submittedName>
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        <name evidence="9" type="primary">mleN_1</name>
        <name evidence="9" type="ORF">ERS852471_01440</name>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36750.1"/>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
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        <property type="protein sequence ID" value="CUO36750"/>
        <property type="gene ID" value="ERS852471_01440"/>
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    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
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        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020883" evidence="7">
        <location>
            <begin position="26"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="8">
        <location>
            <begin position="198"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO36750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="581" mass="61958" checksum="43FA5D37C9A1F21F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELM3</accession>
    <name>A0A174ELM3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265138.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37115">
        <property type="protein sequence ID" value="CUO37115"/>
        <property type="gene ID" value="ERS852471_01450"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="319"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="571"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="640" mass="73953" checksum="3167A728DE8BE6DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EV77</accession>
    <name>A0A174EV77_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265286.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42022">
        <property type="protein sequence ID" value="CUO42022"/>
        <property type="gene ID" value="ERS852471_01528"/>
    </dbReference>
    <dbReference type="OrthoDB" id="576172at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="52871" checksum="81E126705E0462A7" modified="2016-09-07" version="1">MDKLKKIKDNFEGCFDVKYRDIKTILGDATLIFIDDLCNGTWLMEYTILPLRGFGKLKDSEITTPQDLLDKVLDMNMAGLAKDVDDAISHVLQGDAILIYENFEEIIYCEAKNFPRRGIGIPETESVLKGPKEGFNELIVDNVALIRRKLKNPNLKFEAVVLGEESNTAVAITYIKGIAPDELVNSIKEKIKNLDLRFILDTNYIEANLKKQKSFFDTVGYTEKPDEIAAKLVEGRIGIIVDGTPFVITVPYFFLENFQMPDDYYLNRYYTNFNRVLRWIAFFIAAFLPGLYVAIITYHFSMIPTLFIFRLAVSRAGVPIPTFIEVLVMMFAFQFIKEAGLRLPHPIGSAMSIVSALILGDAAVGAGIASRITIIVIALSTLSYFLIPKIHGALSFWSIVISLASAAFGLPGFFAGSLIFIIQICELDSVGYPFLFPMGSTEQYSFKDVLFRGRLDRISKKVILRREKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYV3</accession>
    <name>A0A174EYV3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265278.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41838">
        <property type="protein sequence ID" value="CUO41838"/>
        <property type="gene ID" value="ERS852471_01523"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014578">
        <property type="entry name" value="Pesterase_CT488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033094">
        <property type="entry name" value="Pesterase_CT488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="26853" checksum="2C1E3E7D5367950F" modified="2016-09-07" version="1">MALYAISDLHLAFNVDKPMDIFGERWLNHDEKIKKNWESKINEEDTVLIAGDISWSMRAEDSKYDLDWIDSLPGKKIISKGNHDYWWQSISKLNKMYENTKFIQNNFYTYEDYAVCGTRGWTSPDSDKFTQHDRKIYDRELIRLRLSLDMAKNAGYSKFIVMVHYPPTNENYDETEFTKVFKEYGVEKVIYGHLHGPANLKIKNDTVDGVEYVNTSCDFINFDPVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9K7</accession>
    <name>A0A174F9K7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiol peroxidase</fullName>
            <shortName evidence="4">Tpx</shortName>
            <ecNumber evidence="4">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peroxiredoxin tpx</fullName>
            <shortName evidence="4">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tpx</name>
        <name evidence="6" type="ORF">ERS852471_01584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265398.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44815">
        <property type="protein sequence ID" value="CUO44815"/>
        <property type="gene ID" value="ERS852471_01584"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738458at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO44815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="161" mass="18005" checksum="6F59F5CB98A8778D" modified="2016-09-07" version="1">MKITFNGDPITLVGNPLNVGDDAPDFLVVDNNLKNVTLKDTSGKRIFVVVPSIDTSVCDMEVRKFNEKAASLDDVTVYVISMDLPFAQVRWCGAAGIDRVITLSDYKQKSFGKNYGTLIEEFCFLTRAIFVVDENNKIIYVEYCKDVIDEPDYESALNAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPR3</accession>
    <name>A0A174FPR3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murA1</name>
        <name evidence="7" type="synonym">murA</name>
        <name evidence="9" type="ORF">ERS852471_01708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265621.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51701">
        <property type="protein sequence ID" value="CUO51701"/>
        <property type="gene ID" value="ERS852471_01708"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO51701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="420" mass="45895" checksum="C150CD270A1566F1" modified="2016-09-07" version="1">MEKIIVKGGNKLQGEVDISIAKNSVLPIIVATILNPRKITIKKVPLLEDVLVLVNVLRELECSVEFSDITGDLIIDTSNLKEIEPSNDLIKRMRASFLIVGPMLARFGRCKISLPGGCNIGSRPVDLHLKGLKKLGVDIENGHGYINTKTEGLKGNRIYLDFPSVGATENLMMAAVLAEGVTIIENAAEEPEIWDLARFLNSMGANVEGAGYGRITITGVKELKETKPFTPIYDRIEAGTFIVAAAITKSKITINGVNEEHLMPTIEKLTEVGIKFEINGEKMLVDGTKERVPVDIKTLPYPGFPTDMQPQMMALLSVTKGVSIITETVFENRFMHVGELVRMGANIKIDGRIAIVEGVKQLTGCEVKATDLRAGAAMILSGLVANGETIISEIHHIDRGYTRIEEKFNNLGANVQRIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQT0</accession>
    <name>A0A174FQT0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">ERS852471_01716</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117250.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52081">
        <property type="protein sequence ID" value="CUO52081"/>
        <property type="gene ID" value="ERS852471_01716"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO52081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="77" mass="7569" checksum="3E5428FDE9F41522" modified="2016-09-07" version="1">MDQESVRALAAAIAVLVGIGAAIGIGNATAKAVEGIARQPEASGKITTALMIGAGFAEATAIYGLLVSILLIFVGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FR33</accession>
    <name>A0A174FR33_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265639.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52181">
        <property type="protein sequence ID" value="CUO52181"/>
        <property type="gene ID" value="ERS852471_01718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14897" checksum="EB80EAD2F6EBFF19" modified="2016-09-07" version="1">MNRETKSLLKILIKDVILILAIINLILLVIGHAMLAFIFSLGLLVATINFILSGVMLEKTINSKKKIIKYVFPLSYILRIITIIIIAYPFIYNIEKLLAYVLGFISFFVVLTITWLKMQRGVSKWSHTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTQ6</accession>
    <name>A0A174FTQ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyanophycin synthetase</fullName>
            <ecNumber evidence="7">6.3.2.29</ecNumber>
            <ecNumber evidence="6">6.3.2.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyanophycin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cphA_2</name>
        <name evidence="13" type="ORF">ERS852471_01738</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13277"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23888"/>
            <dbReference type="Rhea" id="RHEA-COMP:13732"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.29" evidence="7"/>
    <dbReference type="EC" id="6.3.2.30" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53111">
        <property type="protein sequence ID" value="CUO53111"/>
        <property type="gene ID" value="ERS852471_01738"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071161">
        <property type="term" value="F:cyanophycin synthetase activity (L-arginine-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071160">
        <property type="term" value="F:cyanophycin synthetase activity (L-aspartate-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009059">
        <property type="term" value="P:macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011810">
        <property type="entry name" value="Cya_phycin_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044019">
        <property type="entry name" value="Cyanophycin_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18921">
        <property type="entry name" value="Cyanophycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02068">
        <property type="entry name" value="cya_phycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="218"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO53111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="873" mass="97258" checksum="55811E48DDE81718" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWM1</accession>
    <name>A0A174FWM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265649.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52475">
        <property type="protein sequence ID" value="CUO52475"/>
        <property type="gene ID" value="ERS852471_01724"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1836435at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="23358" checksum="FF8B41D329E2C39A" modified="2016-09-07" version="1">MYIDKALKRQNKLKKLFYSTMIFLSIFLPMMVYLSNIRSKFIYLYLLILEILIFLSILNKINFYKLKFSCLNNKLKFKNGLFSKENILICDKIAIVHTNDTKEDMEIIIVTTMKFRNKSLKHISKSFLQRYPEVNHEYLMLKKLNPEDTYYFQIINRGALNKYILLEIIYKNCVKAVYTSSAIDNIKIARRQNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5B4</accession>
    <name>A0A174G5B4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265740.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55525">
        <property type="protein sequence ID" value="CUO55525"/>
        <property type="gene ID" value="ERS852471_01769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO55525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="88" mass="10555" checksum="305EC07DE61AD309" modified="2016-09-07" version="1">MNDKEKKIYDEIVADLTKHTRNEIWEWILEDEDGDYDIAIVELEGVLDHIIYYEKGSCNYDDEIIQVYTNCLCRLNDLLESIHWDNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5N2</accession>
    <name>A0A174G5N2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265786.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56927">
        <property type="protein sequence ID" value="CUO56927"/>
        <property type="gene ID" value="ERS852471_01794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011737">
        <property type="entry name" value="CHP02206_TP0381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09529">
        <property type="entry name" value="Intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02206">
        <property type="entry name" value="intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="242" mass="28656" checksum="9EE2E945A7950771" modified="2016-09-07" version="1">MSKFFSLSNIEVNYQITFFEKFTPIVILIFIIIALYLMRNKLRNNKLLDKKLRYSFAIISSIFLTLYYILEWSSNGVTVYNLPLHICFISNILCIILCFTKNKNLFNFVVFTGVLGGISSLLAPELDLSFKYFRYYQFMICHLSIILIPIYFIFIYKYTVTIKDTFKVIFLTEILGICLGIFNEIYGSNYMFVSFTSNYAAKDSVLSYIGEGYFYFINLQFLFLITMLLWYLILKFSYKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9V4</accession>
    <name>A0A174G9V4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265866.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58721">
        <property type="protein sequence ID" value="CUO58721"/>
        <property type="gene ID" value="ERS852471_01835"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1167775at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022353" evidence="1">
        <location>
            <begin position="28"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="333" mass="38533" checksum="DA42CD016F8A4766" modified="2016-09-07" version="1">MKVKSNNLKFVVIVISIIMLMFGCAEKEKERETGEEKERITLSQGAYRNLESNSIYSLNEDNIYEKIDTDELVISYNSESGNYIFIQDDDVFIKYLGKNIKINDNKIKSPKLSNDGKYIFYFCDNGILEPKVIDLENETEVIIDNKVMISGQFADWVADNTLIYYGIRNEDKKSGIFTYDLSNKTEELVYEINKGYVSFLKAIDDEVVFIEDNMENRKILISLEKNNSFEEITEKIIDIKDIIKIDENIYILGKVKDDVYSIYEILGNDLHRVVYDFPLMINLEKGLSVSPKGELLFMGSNEDYNEQNIYSYSDGTVNLISKSKGKYTFINMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBU6</accession>
    <name>A0A174GBU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265852.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58370">
        <property type="protein sequence ID" value="CUO58370"/>
        <property type="gene ID" value="ERS852471_01827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO58370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="16016" checksum="56EAAD56109AAB13" modified="2016-09-07" version="1">MKYQKYKDFLPENIRVKKVSEFERSNKRALFLMIFLNSILLPLNLNKINYDKDIEVFSEDDIYYYENKIKSIKEWININDDYYINISIQNNDGEIYLKDRKFAYNIEEEGFDIKEYKRIEDNMILRVIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GF48</accession>
    <name>A0A174GF48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta-lactam-biosynthetic de-N-acetylase</fullName>
            <ecNumber evidence="3">3.-.-.-</ecNumber>
            <ecNumber evidence="3">3.5.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdaA_2</name>
        <name evidence="3" type="ORF">ERS852471_01859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="3"/>
    <dbReference type="EC" id="3.5.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59778">
        <property type="protein sequence ID" value="CUO59778"/>
        <property type="gene ID" value="ERS852471_01859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10948">
        <property type="entry name" value="CE4_BsPdaA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014235">
        <property type="entry name" value="Spore_PdaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF78">
        <property type="entry name" value="PTHR10587:SF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02884">
        <property type="entry name" value="spore_pdaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022481" evidence="1">
        <location>
            <begin position="30"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="75"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="29959" checksum="9C4025697D8C9413" modified="2016-09-07" version="1">MTFSKKLIRKIIPTLLITLTSTFAYTANASVVPENSELNWYFVNRGKDTLPEGPKESVNILKDYDAYYLGDTESKVIYLTFDEGYENGYTEKILDILKEKGVPAAFFVVKPYITQNPEIIKRMADEGHLVCNHSSHHPSMASITDPSKFKSEFTEVEDAYREVVGTDMPKFFRPPMGKYSINSLKMTKDLGYKSIFWSFAYKDWLKDEQPSEEYAMKKITNGVHPGCIMLLHAVSKTNTNILGAVIDQIRADGYEFKSLDQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGM9</accession>
    <name>A0A174GGM9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ORF">ERS852471_01881</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265947.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60717">
        <property type="protein sequence ID" value="CUO60717"/>
        <property type="gene ID" value="ERS852471_01881"/>
    </dbReference>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="404"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="699"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUO60717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="792" mass="88055" checksum="D23032A101957FB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GR53</accession>
    <name>A0A174GR53_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">artQ</name>
        <name evidence="8" type="ORF">ERS852471_01936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266044.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63747">
        <property type="protein sequence ID" value="CUO63747"/>
        <property type="gene ID" value="ERS852471_01936"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO63747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="24423" checksum="8BC996214BBA427C" modified="2016-09-07" version="1">MNWDFDFITNGQMVYFFQGAKWTLTISLASVVLGVVFGTILTFLKRSKIKLLKFIASAYIEIVRGTPLLLQIFIVYFGLSNVLKINELFAVIIALSLNSAAYVSELIRAGIEAVDKGQMEAARSLGMSESMAMRLIVIPQAIKNILPAIGNEFVAIIKESSMASTLGVAELMYAANVVSTRSFNKTETLIMSAVFYFIMTFSLGRLIKYIERRLKVSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUV2</accession>
    <name>A0A174GUV2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266096.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64868">
        <property type="protein sequence ID" value="CUO64868"/>
        <property type="gene ID" value="ERS852471_01964"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1585038at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="319" mass="36387" checksum="9D1E30DE6EE6442A" modified="2016-09-07" version="1">MEYSICIRTLGTAGEKYEKLIKSIGNLNIKPKEVIVVIPKGYEIPNIKADNQRIVYSEKGMLLQRIVGYEEAKTEYVLLLDDDIEFEANLIDELNLPIIEGKCSITFPIYKDLLLQGGIRSFISAATLSSVPDKKNKNQFVKIMLSGGSRYNSNLDSSKKYLYSESAPGMCVFARREALIKANLRDELWVDNVGYPLREDAALIYKSFLTNNKIIGVQGINITHLDGGSSENNRNLKAAYANTYNQILFWKRFVYSNSKNKVNKFKSNIAIRYWAVATFIYLTIKVILSRDIELYKKSVSGIKNGFRDIKNKQEEIWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0V4</accession>
    <name>A0A174H0V4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol dehydratase reactivation factor, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddrA</name>
        <name evidence="3" type="ORF">ERS852471_02010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66700">
        <property type="protein sequence ID" value="CUO66700"/>
        <property type="gene ID" value="ERS852471_02010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030994">
        <property type="entry name" value="DDR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040916">
        <property type="entry name" value="DDR_swiveling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009191">
        <property type="entry name" value="DDRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028975">
        <property type="entry name" value="DDRA_swiveling_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08841">
        <property type="entry name" value="DDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18427">
        <property type="entry name" value="DDR_swiveling"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82317">
        <property type="entry name" value="SSF82317"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04491">
        <property type="entry name" value="reactive_PduG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDR_swiveling" evidence="2">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="DDR_swiveling" evidence="2">
        <location>
            <begin position="67"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DDR" evidence="1">
        <location>
            <begin position="224"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO66700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="553" mass="60549" checksum="34E64E676E5AB5B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6G8</accession>
    <name>A0A174H6G8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266272.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68997">
        <property type="protein sequence ID" value="CUO68997"/>
        <property type="gene ID" value="ERS852471_02056"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2180880at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="64" mass="7007" checksum="C4CAA0292DE701EB" modified="2016-09-07" version="1">MGHKPNAKEELKAALNDVLYAQSLLLEAINTVEDNDNKQLLQNTLSNVNEALSATKTSAYGFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8P4</accession>
    <name>A0A174H8P4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-1,2-propanediol oxidoreductase</fullName>
            <ecNumber evidence="3">1.1.1.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fucO</name>
        <name evidence="3" type="ORF">ERS852471_02074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266301.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69706">
        <property type="protein sequence ID" value="CUO69706"/>
        <property type="gene ID" value="ERS852471_02074"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008912">
        <property type="term" value="F:lactaldehyde reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013460">
        <property type="entry name" value="Lactal_redase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02638">
        <property type="entry name" value="lactal_redase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO69706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="385" mass="41839" checksum="EB5E801199C5D33B" modified="2016-09-07" version="1">MKKFVLNETSYHGSGAINGIVDEVKARGFKKALIVTDSDLVRFNVVKKVTNLLDKNELVYDIYDEVKANPSVKVVQNGVERFKESGADYMIAIGGGSPQDTAKSIGIIINNPEFADVKSLEGVAPTQNKSVPVIAVATTAGTAAETTINYVITDEEKRRKFVCVDPHDIPVVAVVDPDMMSSMPKGLTASTGLDALTHAIEGYTTLGAWELADTLNLKAIEIIARSLRAAVENDPKGREDMALGQYMTGMAFSNVGLGVVHGMAHPLSAFYDTPHGVANAVLLPYVMRYNKDYTGEKFREIARVMNVAGVDEMTQEEYREAAINAVIQLSKDCNIPQTLKEIGVKEEDLEALTDAAMADVCTGGNPRPCVREEILELYKEAYRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAM5</accession>
    <name>A0A174HAM5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266308.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69895">
        <property type="protein sequence ID" value="CUO69895"/>
        <property type="gene ID" value="ERS852471_02079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="17055" checksum="97222524737E5C24" modified="2016-09-07" version="1">MNEIICSNKDLGNIAEINVHSNCSLVSFVVKFCKLINCCRYFVVLQLQADFGDGEGFVNVAILNKKFCAINNRIPPYRCINYNIFFNNIVIDVPICKEIVKYRIKLIGINCIGIIKCCKKLYKEDNDLNNTNRFCNKYIGKCVIKIHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HC43</accession>
    <name>A0A174HC43_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-propeller domain-containing protein, methanol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266389.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71851">
        <property type="protein sequence ID" value="CUO71851"/>
        <property type="gene ID" value="ERS852471_02120"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738788at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023303" evidence="6">
        <location>
            <begin position="28"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO71851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="30390" checksum="89EC820891557C65" modified="2016-09-07" version="1">MKKIISRVLVIAFMMILCISLSSNISADLKRVVDNATLFSDEEINSLESSINKISHKYNMDIVIVTTNDNQGKSSKEYADDFFDYEGYGLGDKNSGILMLINMDDREAYISTSGNGERYFTDSRVDSILDDVYSYLSDGNYSKGAEIFLKDTSYYLEKGIPSNQYTVDENGDIVLSTEAKIKRVFIALLIALVISSVICGIVVMQYKKPAALPEENYLDRNSINFTRRSDRFITTNTTRRKIPKNNGNSGGSGGRTTTHTSSSGNSHGGGGRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCC1</accession>
    <name>A0A174HCC1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266415.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72552">
        <property type="protein sequence ID" value="CUO72552"/>
        <property type="gene ID" value="ERS852471_02134"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635604at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="406" mass="46910" checksum="49212E67E56F737E" modified="2016-09-07" version="1">MIRQVKHIIKVILIFALVMCWGITLGYANNIERDNDTINFYFENGNINADIVKNIEESKSDISVVGWTEKSLQSATNTDLNRTASDLKVLAIRGNSSLLFDGALLFQDDKDGCLIDTETSYKLFGSTHSIGKEITYGERQLIVRGIHDSTKSNIIVQLLDDDRDVLDGLTIDGTDMTLNKIEEFKTQFGIQEMAISGGIYHNFAKVFAMVFPIIALVLILIKIITHFFKAKRKPVLKIIYISMAIISIFIFFKVTKLNISIPLDMIPNKWSDFDFWSKMWKENIEKLQYVLYMKKYGIDIYNIENLIMSVLYSILTIILFVINLNVNKIKDIKELIYIVSVSVICTFIAVLTIWSKFSFDVNIVMLWLLYPLYICGDYFMRIHEKYFIYKESKLIEDIRIKETVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCX2</accession>
    <name>A0A174HCX2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase alpha/beta fold family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266356.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71237">
        <property type="protein sequence ID" value="CUO71237"/>
        <property type="gene ID" value="ERS852471_02102"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1097359at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="221" mass="25525" checksum="2DC88A7E923094CA" modified="2016-09-07" version="1">MQAIMEPIFHVVYLTTVISLGIIMIRKSKDNKYFKMFGFMSLILGLGDSFHLIPRIYALLTTGLENNAPALGFGKLVTSITMTIFYLILYKIWKIRFDVKNSKLLDITMYALSAIRIILCLFPQNEWFINNPPLSWGIYRNIPFAIMGIIMIYLLYSYGAKNNDRDYKNLGIAVFLSFAFYAPVVLWASENFFVGMLMVPKTLAYVWVVLIGYKEFKKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJI2</accession>
    <name>A0A174HJI2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266526.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75074">
        <property type="protein sequence ID" value="CUO75074"/>
        <property type="gene ID" value="ERS852471_02205"/>
    </dbReference>
    <dbReference type="OrthoDB" id="689906at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="537" mass="62378" checksum="82AEEEE37395EB70" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTE6</accession>
    <name>A0A174HTE6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">thrS_2</name>
        <name evidence="10" type="synonym">thrS</name>
        <name evidence="13" type="ORF">ERS852471_02276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266659.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77481">
        <property type="protein sequence ID" value="CUO77481"/>
        <property type="gene ID" value="ERS852471_02276"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="225"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO77481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="643" mass="73120" checksum="1338F7F29C10D6EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HYH3</accession>
    <name>A0A174HYH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription antiterminator LicT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glcT</name>
        <name evidence="2" type="ORF">ERS852471_02287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78387">
        <property type="protein sequence ID" value="CUO78387"/>
        <property type="gene ID" value="ERS852471_02287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="143"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO78387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="28853" checksum="65EBF5670690B7DA" modified="2016-09-07" version="1">MDLTKKFGQILEAGLEVDKIFTIENEQNQENLKGVINRIDKSFIGLCEEAIREVSDKLGEELNESIHISLIDHLALAIRRIKKGEDIENPFIVEIETLYAKEFELSKIFAEKIYDAYKVSFPDGELGFITLHIHSARNSGKLSNTIKYSYLSNTVIEYIEDCLNIEIDKKSLDYARFVTHIRFAIERILTDKRLKNDLVGVIRNVYPLAYKIAQEVSKFIEEELEKEVTEDEIAYLAMHIERFRVSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1X0</accession>
    <name>A0A174I1X0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplI</name>
        <name evidence="10" type="ORF">ERS852471_02351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266771.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80451">
        <property type="protein sequence ID" value="CUO80451"/>
        <property type="gene ID" value="ERS852471_02351"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="148" mass="16398" checksum="BA42D31B63F7F6D8" modified="2016-09-07" version="1">MKVILLQDVKKMGKKGDVIEASDGYARNYLFPRKLAEEATANALHVVNAKKENERRKKLAELEAAQKLAAELKGKEVTVKAKAGESGRLFGAITNKDIAEVINTTFKLSVDKKKVVMETIKIAGTYDVEIKLYPEVSTKIKVIIVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ICV1</accession>
    <name>A0A174ICV1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.101</ecNumber>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="5"/>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266914.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9clot-a0a174icv1">
        <property type="family name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83986">
        <property type="protein sequence ID" value="CUO83986"/>
        <property type="gene ID" value="ERS852471_02430"/>
    </dbReference>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO83986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="35093" checksum="9466F651E3E53BC3" modified="2016-09-07" version="1">MVKKFIKTILIVFVIILFLIIAFLILLKYFASKPINSEYFNNVVAGGVLEEKYIAYGEYDVTSLEIDSNEELFSKYKIWYPTELVHNSNKKYPIVLFVNGTGVPYSKYGATFDHLASWGFVVIGNDDENTASGESSSITLSYILSLNNNEKSIFYNKLDIENIGISGHSQGGVGAINTITNFNNSSMFKSIYTASTTSLELANALEWNYDITKVNIPYFMVAGTGKADAETIAPLDSLIRNFEALNDNIKAIMARRKNIDHGDMLIYADGYMTAWFRYTLMNDNEALGVFSGASPEIFQNVDNWQDVQSKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IED0</accession>
    <name>A0A174IED0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yicJ</name>
        <name evidence="4" type="ORF">ERS852471_02415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266886.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83470">
        <property type="protein sequence ID" value="CUO83470"/>
        <property type="gene ID" value="ERS852471_02415"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="457" mass="50082" checksum="BF225FABF76FA9FE" modified="2016-09-07" version="1">MKTVESVYTEKIGVGEKLAYGCGDLASNLVMVLTGTYISFFYTDALGLNVGIVGTLILISRFFDGFTDIIMGFIMDKTKSKHGKARAWMLWLAIPFGVCTALLTMVPNLGNVGKYIYVFISYNVVTTFLYTAINIPYGALNSLMTRDQTQRETINVFRMTMAQIGGLIINALTLPFVNAVGGSTNQSAWMIVSSVYGILATLLFLLCFVKTKERVNVVSDEDRKIGFIKTLKLMIKNDAWLLICAIWVVNILGMAIGMGVGVYYAKYILHSEAYFGFLAVIQQGVSIVLMAMMMPFVKKFGKRNVALVGTIISLISQLLIIVNPTSFSWLVVCNIVKGIGAAPLMATLFAMMADSIEYGHWKTGVRIEGTLYSATTFGAKVGGGVGMVVATTVLGMAGYNGALAVQSESAITAISNLYIYAPIIFLVILPILYCFYKLDKQYPQVMKELAEREDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFP5</accession>
    <name>A0A174IFP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grxC_2</name>
        <name evidence="2" type="ORF">ERS852471_02472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266995.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86042">
        <property type="protein sequence ID" value="CUO86042"/>
        <property type="gene ID" value="ERS852471_02472"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO86042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="75" mass="8382" checksum="8FFEC6F98CFC0DFB" modified="2016-09-07" version="1">MVKVYSTNTCPWCDKAKSYLKSKGIEFEELNVQEDMVAREEMIKKSKQMGVPVLDVNGTIIIGFDKPAIDTALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IH91</accession>
    <name>A0A174IH91_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase, TrmH family group 3</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoU</name>
        <name evidence="3" type="ORF">ERS852471_02485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267023.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86563">
        <property type="protein sequence ID" value="CUO86563"/>
        <property type="gene ID" value="ERS852471_02485"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO86563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="32565" checksum="ACCFBCCCA25C32A7" modified="2016-09-07" version="1">MAKRENPRRREREFNKFQEKQARAERRRDYSDNYSKRNNEAMHEEIREDLVLGRNAVIEALKSDTTIEYLCVSKGDLEGSIKVVLSLAKDKNVVIKEVDRRKLNEMCGGANHQGVIAKVTPFKYSEVTDIINRAKRKGEDPFIVILDEIEDPHNLGSIIRTAELCGVHGIIIPKRRNVGVTPTVYKCSAGAIEHMRIAKVTNINATIDQLKEEGIWIYGADIDGKDFSYNTNFSGACALVIGSEGRGISKLTLKKCDVLVKIPMIGKINSLNASVAGGIMMYEVLKGRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IKM7</accession>
    <name>A0A174IKM7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Negative regulator of genetic competence mecB/clpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mecB</name>
        <name evidence="10" type="ORF">ERS852471_02470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266989.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85918">
        <property type="protein sequence ID" value="CUO85918"/>
        <property type="gene ID" value="ERS852471_02470"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="417"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO85918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="812" mass="91859" checksum="2A937FD325A7CA3B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IM52</accession>
    <name>A0A174IM52_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267080.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88462">
        <property type="protein sequence ID" value="CUO88462"/>
        <property type="gene ID" value="ERS852471_02531"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="31570" checksum="13371381CFAFC013" modified="2016-09-07" version="1">MKDLLKSKNFYIDVVVIILGCFIYSLGVNLFLTNAKLVSGGVTGIALILQYVSDIPSGITVFLLNIPLFFISYKFLSKRFTLYTAIGMLSISLSLIITKPLSALIQVNDILLYCIYGGVLCGIGMGLVFYRNGSTGGIDIITMVIRKKYSNFEIGKLNFVFNLIIVAIAALIFGLPQALYTLISMFIQGTILDKVLNGFTSKKLLLILTEKENEIINYVINDLHRGITSIMAEGEYTHSKKKMLYVAITSSQFISLKNKILRIDPKAFITIIDASEVKGKGFINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IQ93</accession>
    <name>A0A174IQ93_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpsI</name>
        <name evidence="9" type="ORF">ERS852471_02528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117054.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88336">
        <property type="protein sequence ID" value="CUO88336"/>
        <property type="gene ID" value="ERS852471_02528"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO88336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14625" checksum="86F75961D2D65100" modified="2016-09-07" version="1">MAKVQYMGTGRRKKSVARVRLVPGNGNVVINKRDIETYFGLETLRMIVNQPLVLTGTKEKFDVLVNVHGGGFTGQAGAIRHGITRALIKSDENLKSELKKAGFVTRDPRMKERKKYGLKKARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVC4</accession>
    <name>A0A174IVC4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89996">
        <property type="protein sequence ID" value="CUO89996"/>
        <property type="gene ID" value="ERS852471_02556"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2058674at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021598">
        <property type="entry name" value="DUF3221"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11518">
        <property type="entry name" value="DUF3221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="13170" checksum="CC2A1365059978E0" modified="2016-09-07" version="1">MIIIKKCFLFFAYIISFLLITGCFSSESSTITGRYLKVKNNSMIIDEYGCPIVMSNDSKKEDLFKDLENGDRININCIAVLESYPGQCSVYKIKFIEKGTIDDIPKETLDTLKEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J1E8</accession>
    <name>A0A174J1E8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DedA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92086">
        <property type="protein sequence ID" value="CUO92086"/>
        <property type="gene ID" value="ERS852471_02611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO92086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="48" mass="5302" checksum="CE944E472A53AB5F" modified="2016-09-07" version="1">MFNSESVIEIFQRRLLPFMPSGVITLTSAVSDVNGIVFTIDTFLGKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J4K9</accession>
    <name>A0A174J4K9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267219.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92019">
        <property type="protein sequence ID" value="CUO92019"/>
        <property type="gene ID" value="ERS852471_02609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024842" evidence="2">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO92019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="24973" checksum="6D1AE8AE99349C87" modified="2016-09-07" version="1">MKKKNLSLMLLSLVIASETLISMPSATIKVSELKPVEVSNPSTNSDKSGDRESKKEEKPSAPAKEQKPAEDMKKKPCEDNSKKVVPSTPAKEEKPKEDMNKKTMEKEQTPATPAKEQKPAEDMKKKPCGEKPKDSTKTEEQTPAAPTKEIKPKCKEDKTSNKKDAETKEEKETKKDKKCKDKKDKKDKHHHKDHDEDKHDKDHDKDKNKCKTPCRDSKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J7E5</accession>
    <name>A0A174J7E5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endopeptidase La</fullName>
            <ecNumber evidence="3">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lon_1</name>
        <name evidence="7" type="ORF">ERS852471_02641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267277.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93558">
        <property type="protein sequence ID" value="CUO93558"/>
        <property type="gene ID" value="ERS852471_02641"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014251">
        <property type="entry name" value="Spore_LonB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02902">
        <property type="entry name" value="spore_lonB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="91"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="6">
        <location>
            <begin position="348"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO93558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="551" mass="60510" checksum="D1D5B30CF4804569" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDU8</accession>
    <name>A0A174JDU8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein CotS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cotS2</name>
        <name evidence="2" type="ORF">ERS852471_02736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267456.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97882">
        <property type="protein sequence ID" value="CUO97882"/>
        <property type="gene ID" value="ERS852471_02736"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="47"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO97882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="354" mass="41638" checksum="5EDFC49B65570D7E" modified="2016-09-07" version="1">MASEKLLFNNDGLSLTNIKKYILPLFSLENATVSMIKFKDTDKQRAVFKVETQSNSYCLKKVYYNEENLLFVYSAMEWLYRNNLNVPRLIPSKNNSRFVLFNSMIFILTPWIDGDKCDFDNPTHINLSCQTLGKIHKVSKNFFPIEGSTERKGLEDFHLSTSKHFNQLLENANYASTIKDRFSNIYLDNLDYNLDLAKLSLEISSTIDSSELSTSLCHGDYVNKNIIIDNQNKVFIIDFDKCKYDYSAYDLSYFLRRLLKRPTTNWETKITIDVLDSYLKENYLTPSDFKYILAYLAFPQKYWKISRDYYKNIKKCNKKSFVTLLAKGLDRTSNQLEYVKNMIVVLEKYYNVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JHT8</accession>
    <name>A0A174JHT8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267450.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97756">
        <property type="protein sequence ID" value="CUO97756"/>
        <property type="gene ID" value="ERS852471_02733"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1760987at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025642">
        <property type="entry name" value="DUF4342"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14242">
        <property type="entry name" value="DUF4342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4342" evidence="2">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="210" mass="22654" checksum="1A45E2C8C691A8FC" modified="2016-09-07" version="1">MEITLEQVDKVKERTGVSYAEAKSALELTNGDVLDAIILLEEKAKEKYENGIGAENSTGGTVNNNTETIAELKAWLKDLINKGNISRIKVSKDGDTIVDVPVNAGIAAAVIAVIIPPILAFVVVAAVVTKVTIEITKADGTVEVVNKYISKAVNDAKDKASDIADVVKEKVSEVNIDALKKYDKNIVSKENDNNTFVYTVNFEEEEKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JXB9</accession>
    <name>A0A174JXB9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267651.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03261">
        <property type="protein sequence ID" value="CUP03261"/>
        <property type="gene ID" value="ERS852471_02843"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026074at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017016">
        <property type="entry name" value="UCP033595"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20124">
        <property type="entry name" value="DUF6514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033595">
        <property type="entry name" value="UCP033595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP03261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="12525" checksum="F9CB3952423A3BBD" modified="2016-09-07" version="1">MKIVESLSLAIENKGKKIMYFYRLTQCQTKSGQAFGIEVERQDFKDESLINIERDSVDIISTKKEKVRPILELLYKNNVSPIHLIDIIGAYVDECIEDFNNEEVLVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JYG1</accession>
    <name>A0A174JYG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267633.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02807">
        <property type="protein sequence ID" value="CUP02807"/>
        <property type="gene ID" value="ERS852471_02833"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP02807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="29919" checksum="EA3B449D92495C0B" modified="2016-09-07" version="1">MKKIKEYLLITIGIALTAIALEYFFFPNDIASGGVSGIGLVVNSLTGISTSIVVFVLNILLFVVAFFVLGKSFGAKSIYATIMLSVFMYIIETFFTPGILTENLFLASFFGSGILAMGAAIVFNEGASTGGTSIIAAIISKYTAIGVGSAVLITDSLVCLMAIGAFGVDKGLFGFFSVVMIGILIDKFIDGFNTCKQVFIVTNKEKLVLEYITKDINRGCTVLNAQGGFTGSDVKIIYTVLDTKQFITLKKFIKEKNPEAFITVNESAEVLGEGFKSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K4F2</accession>
    <name>A0A174K4F2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267754.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05711">
        <property type="protein sequence ID" value="CUP05711"/>
        <property type="gene ID" value="ERS852471_02901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1911435at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP05711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="30463" checksum="A1F026C4CE3A7002" modified="2016-09-07" version="1">MEHYKILGVDENATMEEIKEAYDNKVKQFKEEIKDERRAKKFIEVFDKAYEEIKLEREKIQNQQTMIIDFKEADSIQELKDDLDKSEENFQCSIEGEEFDESEERSIVTKEKRKSNSKISSAKKGKSNNKKSSKTKDVENEKTMKKANKKVVVKNRKESSTIAKEIKLPFKLLAIPVIVVLTIILFLCKILNLISWIASKAIIIASIAGASIHGYQIYIGYAVQYKIFILCAIGFIVSLFLPSILRVLPRVLEGINNRLKRFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K722</accession>
    <name>A0A174K722_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">odcI</name>
        <name evidence="5" type="ORF">ERS852471_02949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267840.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07953">
        <property type="protein sequence ID" value="CUP07953"/>
        <property type="gene ID" value="ERS852471_02949"/>
    </dbReference>
    <dbReference type="OrthoDB" id="485164at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027464">
        <property type="entry name" value="Ornithine_deCO2ase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00703">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="4">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP07953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="716" mass="81333" checksum="B5DFBE0D9F1940B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KDH8</accession>
    <name>A0A174KDH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjjG</name>
        <name evidence="1" type="ORF">ERS852471_02961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267862.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08486">
        <property type="protein sequence ID" value="CUP08486"/>
        <property type="gene ID" value="ERS852471_02961"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP08486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="26526" checksum="22BE6093C97A107A" modified="2016-09-07" version="1">MKYEVILFDADETLFDFKKSEKEAFKNTMIKFGFDYDENYHLKIYQEINSAIWKEFEEGLITQAKLKVERFKRLSDKLGVSFDENEFAKSYMEHLADASFLYDGSVELLEDISKSHKLSIVTNGLTAVQDKRIRKSTVAKYFDTVVISEEILISKPNPEIFEHTLKTINHSDKSKVLMVGDSLTSDIQGGINFGIDTCWYNPKKLENKTSIKPTYEVSSLDELKEILINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KED3</accession>
    <name>A0A174KED3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cmpR_2</name>
        <name evidence="3" type="ORF">ERS852471_02954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267850.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08188">
        <property type="protein sequence ID" value="CUP08188"/>
        <property type="gene ID" value="ERS852471_02954"/>
    </dbReference>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP08188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="34250" checksum="B9D6C3B1897404A6" modified="2016-09-07" version="1">MTIKHLRVFNEVAESGKMSIAAAKFYLSQPTVSQIIKELEEHYGFLLFERLSKKLFITEEGKKLLYYSKQVVKQFDELESKMLESSKVQSFRIGSTITIGSCLINDIIKEFERIDDTVEIYSYVNNTQAIEDELLKANIDIALVEGVVKSSDLVSIPVVDDYLVLVCSKNHPLAESRHFTVEELKNQGFAMREKGSGTREQFENYISKQGISIKESVVANCPTALINAVIEQNCLAVLSVRLVEEQIKNGSIVVLKNECCAWNRSFSIVYHKNKFLSHSMVNFIQVASSFKRSEIMDSIMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KF91</accession>
    <name>A0A174KF91_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_02948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267839.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07909">
        <property type="protein sequence ID" value="CUP07909"/>
        <property type="gene ID" value="ERS852471_02948"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1023685at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP07909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="34914" checksum="4FB04795B144DB86" modified="2016-09-07" version="1">MDIIFGTVLLLVVLGLFTLFSYKAPNGMKAMGALANAACASFLVEAFHFAFFGEVLKIEFLQGVGNANGSLGGVAAGILVPLALGVSPVYAVLTGLAVSGFGILPGFIAGYLISYVVKFLEKKVPAGLDLIAIIIIAAPLSRLIATGVNPIVNGTLLKIGDVLLSSANSSPVIMGIILGGILTVVATAPLSSMALTAMLGLTGVPMAIGALAVFGSSFMNYVFFHKMKFGSKKDTIAVAIEPLTQADIISANPIPVYVTNFIGGAASGIIVALMGLVNNTPGTATPIAGFAVMFAYNPAIKVLIAAAGCIIVSVISGYIGYLIFKNKKILTADEIRNPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KFM6</accession>
    <name>A0A174KFM6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267961.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10783">
        <property type="protein sequence ID" value="CUP10783"/>
        <property type="gene ID" value="ERS852471_03009"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1533839at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="135" mass="14451" checksum="FBFAFB3192CFBC9D" modified="2016-09-07" version="1">MRVIKAIIGGFIAALVINGVWGIFTENLGTLGGILAAVFLVGTMWFLNHYIGLIPNEKNSAFIDMGISIGIACIVRDMIRIGNVDEILTSIPTLILVIVGGSIGGTLSVFVKKDMKKDKESSETIKDIDSIESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KH77</accession>
    <name>A0A174KH77_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
            <ecNumber evidence="6">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">iolS_3</name>
        <name evidence="6" type="ORF">ERS852471_02976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267900.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09537">
        <property type="protein sequence ID" value="CUP09537"/>
        <property type="gene ID" value="ERS852471_02976"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP09537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="373" mass="42802" checksum="58FEC4F649F10B49" modified="2016-09-07" version="1">MLYREYGQTHEKVSILGFGCMRFPTIDNKIDEEKSTEMIQYALSKGVNYFDTAYTYHNSESESFVGKALEHCRKDIFIATKLPSWLISSRDDMDRIFNEQLNRLRTDYIDFYLVHALNKEYFTNLKDNGLFEFLDSIKKSGKAHHIGFSFHDSLDVFKEIVDSYDWEFCQIQYNYLDTDYQAGTEGLEYAANKGLGIAIMEPLRGGKLASNIPNDIQDLWDTANNKRNPVEWALKYLWNDSRISVVLSGMSSFSNIIDNINFAETSTPNCLNEEELNLISKVTSSYKAKIKVNCTECKYCMPCPVGVNIPRNFDLLNKASLFEDIESSKKSYNSMSEESKAISCVKCGKCEKLCPQSIRIREKLEEVVNTLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KK25</accession>
    <name>A0A174KK25_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligopeptide transporter, periplasmic-binding protein OppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">oppA_2</name>
        <name evidence="4" type="ORF">ERS852471_03039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268023.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12343">
        <property type="protein sequence ID" value="CUP12343"/>
        <property type="gene ID" value="ERS852471_03039"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026177" evidence="2">
        <location>
            <begin position="30"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="97"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="560" mass="60935" checksum="58F663ECEE687AC0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KPQ4</accession>
    <name>A0A174KPQ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lacZ_3</name>
        <name evidence="6" type="ORF">ERS852471_03032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268007.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11575">
        <property type="protein sequence ID" value="CUP11575"/>
        <property type="gene ID" value="ERS852471_03032"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1936769at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP11575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="22278" checksum="F2D0685BD4B85BF9" modified="2016-09-07" version="1">MCPLLYTNTNKVNVDVKYLVKEDGLIEITGEYFGTEGIPNIPEFGMMFILKSDLDKVLWYGRGPSDNYTDRKDGCKIGIYEGCVNDLVPYLRPQEYGNKSDVRYAKVFSDNGFGLIFEGENLNFSALPYTPHEIENAAHSFELPPVYHTIIRVSQEQMGVGGDDTWGAPVHEEFTISGEENHKFKFIFGVDLEKNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZE7</accession>
    <name>A0A174KZE7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoR_13</name>
        <name evidence="11" type="ORF">ERS852471_03083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268107.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14669">
        <property type="protein sequence ID" value="CUP14669"/>
        <property type="gene ID" value="ERS852471_03083"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="280"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP14669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="500" mass="56738" checksum="45D7E3AB5F0DA6DD" modified="2016-09-07" version="1">MNKSISKKLFTITFSLILSVFIINMVVQLLFFEDFYLEKKVKDLKNEVNTFRTMYSYQLVNKNTLYNALSSYEESNNSKMAIFSLDGKLKYLTNYEGGMDDYTALTAFCADLLSNRELIDRVLTHDTVEWTIFTDKSSDNKKIGVVSPMSLQNFNDSIIISVSSIQPIQEAASVIKSFYFYLLICILFVAIILSNIYAKLISKPLIKINRVATKMSNLDFNAKCDVTSQDEIGSLAKTLNFLSSNLENALDDLKDKNLKLENEIERERNLENMRKDFVTSVSHDLKTPIGIISGYAEGLKDDIVTGEDRKIYLETIIDEANKMNSLLNSMLDLSRLETDNATLTLEDFNIVRLLQGMIKKFSLELSNKKITANFITIPPYAYVTGDILKIEQVIQNIITNGIKYSPEGSNINISVLEENDNFTINIENTGVNIPEKELENIFAKFYRLDKSGDRTKKSYGLGLSIVKRILDIHNSIYSISNTSNGVLFKFTLPKSTDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LAD8</accession>
    <name>A0A174LAD8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gph</name>
        <name evidence="1" type="ORF">ERS852471_03205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268315.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21123">
        <property type="protein sequence ID" value="CUP21123"/>
        <property type="gene ID" value="ERS852471_03205"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP21123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24529" checksum="6E58ADF500E27D6F" modified="2016-09-07" version="1">MIKSIIFDLDGTLLNTIEDLANACNYALTTLGYKTHEVEKYKTFVGNGRYKLVERMLPEDRRDMENIEKALKLFDTYYEKHMIDMTKPYDGIMEMLDSLINRGINIAVVSNKPHEFTTEVVKNYFGDRFKVVYGHKKNTKEKPDPWAVLEVIEEFNVNKDECLYIGDSEIDINTAKNAGVKSVGVEWGFRGKGELEAAGANYIVNKPEQILEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDE7</accession>
    <name>A0A173XDE7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppB_1</name>
        <name evidence="7" type="ORF">ERS852471_00019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262688.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49822">
        <property type="protein sequence ID" value="CUN49822"/>
        <property type="gene ID" value="ERS852471_00019"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN49822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="327" mass="37006" checksum="6EA65A955FEBB78C" modified="2016-09-07" version="1">MIKVVLRKIFQCIIAIFILSLVVFYISRLSPGDPLKAYHGNAVERMSMEEKEKARDRLGLNEPIYIQYGKWLKNVAKGDFGISYKYKRDVTSVIKDVYKNTIILGGLAYILTFVGALIIGIFCAIHEDKLIDKIIMTIGNITSSIPSFWIALILILIFGVNLGILPTSGAYSIGNESDIADRMIHLILPLVVLVIGHLWYYGYMVRNKILEEMREDYVLLAKVKGLTKRQVVYRHCLRNIMPSFITIMAISVPHILAGTYVIEQVFSYPGIGTLIFESAKYHDYNMLMVLSLITGIIVLISNMIAQIINIKIDPRMNYQGGETFEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQD6</accession>
    <name>A0A173XQD6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262815.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53783">
        <property type="protein sequence ID" value="CUN53783"/>
        <property type="gene ID" value="ERS852471_00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN53783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16834" checksum="F06E41130FCD3386" modified="2016-09-07" version="1">MSFNRNIVDDKSKEEVLALVSSQEFKDIFLKYNIDNVIIFGSLSTDKFNEESDIDIAIIGSEKISSKLDLTLSLELEDFLGRSIDLIDINDEDIENIIKIEALNSDMVIMKNEKYDEKYVYYDILFKENIEFWNRLDKVILESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSG9</accession>
    <name>A0A173XSG9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262851.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54674">
        <property type="protein sequence ID" value="CUN54674"/>
        <property type="gene ID" value="ERS852471_00112"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2133728at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="24191" checksum="9759C28507E704C1" modified="2016-09-07" version="1">MSSDLKELKGLICRKRISKIKKKYESAEKRVYRKLLDCNKNKNEEYLTKCVFIEFKKRYFSDFCKRVDDLVTSYTVGIEPAMREYVFAKRRDRTFEVLVLIKNILDRNCIRWAIMNDYIKCREECICPESICIVVSKEHMNAACNIFNVIGEKRGENIYIVNGVEVHLSFGYAIENRSYNLKEYDIGYCNLDSENIPVLVEPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y127</accession>
    <name>A0A173Y127_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YlmC/YmxH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262953.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57353">
        <property type="protein sequence ID" value="CUN57353"/>
        <property type="gene ID" value="ERS852471_00166"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1869839at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014238">
        <property type="entry name" value="Spore_YlmC/YmxH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40061">
        <property type="entry name" value="PTHR40061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02888">
        <property type="entry name" value="spore_YlmC_YmxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="11779" checksum="537E514651A50CCC" modified="2016-09-07" version="1">MKDYEYYEKKADNSLKMLSELERFEIFNLESAEKYDNAQNIDFIIDENGYIKYMIVGVNGSKFSFLSSREYVEIPWDCVTKVGANVIVISADETKIRRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2K2</accession>
    <name>A0A173Y2K2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ORF">ERS852471_00162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262945.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57155">
        <property type="protein sequence ID" value="CUN57155"/>
        <property type="gene ID" value="ERS852471_00162"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="181"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN57155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="35555" checksum="4A3F50ACF6A6BBF6" modified="2016-09-07" version="1">MLVLDNVNLLEPKRSNYVALGSFDGLHIGHLSLINKVKELAKDNEGKSMVFTFKNHPRTVIMAENNLDLLMTNREKIDILLNENVDILALKTFDKEVMKMDPEEFIKWLCNDYSIRGIVVGFNFRFGYKNLGDIDLLNELKEKYNYELYVMEPYIYEGDVVSSTRIRKEILNGNVAIANKMLSRPYTINGNVVHGKKLGRQIGFPTANINLTADKLIPKVGVYYTNVEVNGKIYKGITSIGNNPTVNGKELTIETYILDFDKYIYDEEIKLYFIDRIRDEMKFSGIDELVCQLKKDKILAEGKETIRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAS8</accession>
    <name>A0A173YAS8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">appC</name>
        <name evidence="7" type="ORF">ERS852471_00232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60929">
        <property type="protein sequence ID" value="CUN60929"/>
        <property type="gene ID" value="ERS852471_00232"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="206"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN60929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="415" mass="46225" checksum="2B7204289D1A6EBA" modified="2016-09-07" version="1">MISQLKQVFHDKKFLLGFIIFITILFVTIVYPILVSYDPLEMVGGLFYKPGNYVSITDVVESKSYKLNIDTKAGRLESKLSLEDRAEMATWLEKFGGVSISEINVTNAEELVKLWNKYYYSNNSQEGLISAKKKYYVRLDNKIDGILEESEIVISTVDEENGELVEGTKVNSKDFVNVKDISNQRTFVLGTDNFGRDVLTELVYATRTSLKIGLIAGLIATLIGLMLGLLSGYVGGLLDDIIMFITNLFTVIPSFVILILISYSVGQSARGITMVASIIGLTSWTWTTRSVRSQVISLRNRDHVNLSKLSGHSLFRIILTDILPYVASYVIMALILQISSGILAEAQLSMLGLGPATTKVTTLGLMMNWAMQYKAPLSNAWWAFLPVIFSIALITFSLNLMNTGLDKVFNPQLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YB27</accession>
    <name>A0A173YB27_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">araC_1</name>
        <name evidence="7" type="ORF">ERS852471_00235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263079.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61094">
        <property type="protein sequence ID" value="CUN61094"/>
        <property type="gene ID" value="ERS852471_00235"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="374"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN61094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="482" mass="57050" checksum="3D48EEB9A014C582" modified="2016-09-07" version="1">MENIIIVDHKEARIGRIREIIKYSEIKVETIIECNSEEDAYEKIKNNNINLLIICLTKNHSDGIILLKKINKIRLKPKVIIISDLDTPSGIIELLRCGIKEYLYGNFQDSELITTIKKLEEEYKEEKEEVTEKVFLLYSQIKHLLVQNKLDENVAKSLNSILSKYITNICYKIICTNYKMKSNINNNCFYFHNINTHNVIIIESDKAERFINENLNGFGFGISNSYTDIKCLMNALNEAIELRKENFFLQLNKKVNIKEERIIDEFEIERFINLIGTNRLEVSTSYLKRIVILVKRSEISKDSFLDLINKIYSRIYETYKGIIEEEKIKLELLENAFNYTNIDIYCEEIYLLMILINKKLLNKYDFYKNRIKIEEAVRYINKNFKDNINMTFISNYVSMNYTIFSIDFKEYTGKNFVNYLKEVRLKEAKRLLDETDMKINEISEAVGYDNDKHFMKTFKGVFSVTPTEYRKNIKSGRDNRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YID6</accession>
    <name>A0A173YID6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA_1</name>
        <name evidence="7" type="ORF">ERS852471_00245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118049.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63509">
        <property type="protein sequence ID" value="CUN63509"/>
        <property type="gene ID" value="ERS852471_00245"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN63509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="11471" checksum="EBAC2E1A4A784DB2" modified="2016-09-07" version="1">MVKHVQENEFSAEVLNFDGVSVVDFWASWCGPCKMIAPIFEEVAGEITNAKFVKVNVDENPNLANQFRIASIPTILIMKNGAPVDTLVGFMPKPQLKDAIAKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJP9</accession>
    <name>A0A173YJP9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263137.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63989">
        <property type="protein sequence ID" value="CUN63989"/>
        <property type="gene ID" value="ERS852471_00253"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1705038at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="zinc_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_15" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN63989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="126" mass="14975" checksum="F25C0857D61124B8" modified="2016-09-07" version="1">MFFIGIFGVDNKERVINESQNIYCKGCNKYELGKVIKKYSFFHFFFIPLFKWNEKYYVIYNECNHIYGISKEKGKRIEGGEKIEINYWDLKDLDGYSYNGGNICINCGRKIEEGFVFCQYCGEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YR37</accession>
    <name>A0A173YR37_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">ERS852471_00294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263209.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66040">
        <property type="protein sequence ID" value="CUN66040"/>
        <property type="gene ID" value="ERS852471_00294"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="60"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN66040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="29388" checksum="18F9E98EDB5A9BC6" modified="2016-09-07" version="1">MRKFKESILKVLLYLSAVITVSILVFILGFIFIKGYKIINFNYLFSEYKPSGGGGIKPFIISTLYTVALSLAIATPIGVLSAVYLQEYAKQGKMVKIIRYSTEALAGIPSIVYGLFGAAFFVAALNFGYSLIAGSLTLSIIILPVIIRTTEEALKVVPSSYREPSLGLGATKFQTLYKVILPSATPGILSGVILSMGRVIGESAALFLTAGTVYKIPKSIMSSGRTLTVHAFLETKEKGDIASAAAAGIVLIVMILILNIVAKLISKKLNKAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YTS0</accession>
    <name>A0A173YTS0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAK2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263261.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67621">
        <property type="protein sequence ID" value="CUN67621"/>
        <property type="gene ID" value="ERS852471_00322"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1554133at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN67621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="546" mass="59919" checksum="188940A70115FDB8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCX7</accession>
    <name>A0A173ZCX7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenium-dependent molybdenum hydroxylase system protein, YqeB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263473.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74094">
        <property type="protein sequence ID" value="CUN74094"/>
        <property type="gene ID" value="ERS852471_00443"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1072730at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017695">
        <property type="entry name" value="Se-dep_Mo_hydrolase_YqeB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03309">
        <property type="entry name" value="matur_yqeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="27826" checksum="3769E33EE82FE1C6" modified="2016-09-07" version="1">MLVLIKGAGDLATGVAHRLKRCGFDVVMTEIEEPTTVRRTVAFSQAVYDCKVEVEGVKASLVKDIQMIRENIDNGIISVIVDKDANIIEVLKPDIVVDAIVAKKNTGTSIDDAPIVIALGPGFEAGVDCDLVIETKRGHYLGRVITKGKAIPNTGVPGNIGGHTVGRIIRATSDGIINPVSEIGDYVEEGQVVAYIDKIPVYASISGIVRGMLQGGIEVFEGMKSGDIDPRCKKEHCFTISDKARSIGGGVLEGILFLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFZ5</accession>
    <name>A0A173ZFZ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-2,6-bisphosphatase</fullName>
            <ecNumber evidence="1">3.1.3.73</ecNumber>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobC_1</name>
        <name evidence="1" type="ORF">ERS852471_00461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.73" evidence="1"/>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263505.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75037">
        <property type="protein sequence ID" value="CUN75037"/>
        <property type="gene ID" value="ERS852471_00461"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="22453" checksum="993B645C04321754" modified="2016-09-07" version="1">MKKVFYMMRHGQTLFNLRRKIQGWCDSPLTDFGIEQAKAAGEYFKEIELDHLYCSTAERCSDTLEIVTDNSMPYTRLKGLKEMNFGTFEGESEDLNPDRETFETFFTKYGGESRDMCRERVVKTCHEIMEKEDHKIVLAVSHAGACLRFLEHCYDPSNLPRNAFSNCAIFKYEYEDGKFTFVEVIQRIPETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHW8</accession>
    <name>A0A173ZHW8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">puuR_1</name>
        <name evidence="2" type="ORF">ERS852471_00478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263533.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75992">
        <property type="protein sequence ID" value="CUN75992"/>
        <property type="gene ID" value="ERS852471_00478"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="20830" checksum="326A17BCC4FD962A" modified="2016-09-07" version="1">MEELNIGKKIQDFRNARNTSVRELSKKSGITASMLSQIERGLVNPSINTLRAIANTLDVPLFYFFKEDPEKEELVVRKNNRKTIGFPNQSDVRYDLLVPNTLGSIEFCMMEIPNNSKSVEKAESHKGEEVAYVIEGRVDIIVAGIRYSLDEGDSIRIPPMTDHKWENIDTKLAKVIFAVTPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0A3</accession>
    <name>A0A174A0A3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263651.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82082">
        <property type="protein sequence ID" value="CUN82082"/>
        <property type="gene ID" value="ERS852471_00533"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366413at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="88"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN82082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="657" mass="74142" checksum="3E32D5704BDDBE0F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1K4</accession>
    <name>A0A174A1K4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flr_1</name>
        <name evidence="2" type="ORF">ERS852471_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81288">
        <property type="protein sequence ID" value="CUN81288"/>
        <property type="gene ID" value="ERS852471_00522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="19234" checksum="389D38BD0ECDC115" modified="2016-09-07" version="1">MKFYENLSEAMENLTKRGAFLTVKENGKVNTMTISWGYVGYSWNKPFFVAMVRPQRYTYEFIQTAKDYTISIPYSDEMKKALTICGTKSGRDIDKEKEANIKFVPAKLTETPVVDNCNMYYECKITYVDRIHKDSFPEELKKNYPKDDYHYIYYGEIVECYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A240</accession>
    <name>A0A174A240_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263638.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81468">
        <property type="protein sequence ID" value="CUN81468"/>
        <property type="gene ID" value="ERS852471_00525"/>
    </dbReference>
    <dbReference type="OrthoDB" id="988251at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="203"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="37621" checksum="C1FC89D6CD40F489" modified="2016-09-07" version="1">MKILKFMLIFIPISIVGKFMNFSPSIMFILAALSIIPLAGLMGEGTEEISFYSGPKIGGFLNATFGNATELIISFFALKEGLFEVVKSSISGAIIGNILLVLGASMFAGGLKHKVQKFNINVVETTSSMLLFAVIGLCIPAVFTHTLNQSLLNTRYEGLTLVVAIIMFILYLCSLFFSFFTHKDLYSVTYEEEGKAKWSLKKAIIVLVVATILIAIESEFLVSGVEDITSKLGLSEFFVGIILIPIIGNAAEHTTAITMALKDKMDVALEIALGSSLQVILFVAPILIFLSLLFTPMSIIFNQFELVALIVSVLIANKVAGDGQSNWLEGAQLMAVYLIIAAGFFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A3C4</accession>
    <name>A0A174A3C4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pgsA_2</name>
        <name evidence="18" type="ORF">ERS852471_00545</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263671.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82807">
        <property type="protein sequence ID" value="CUN82807"/>
        <property type="gene ID" value="ERS852471_00545"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUN82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="22207" checksum="A3FB6E3F4924CF76" modified="2016-09-07" version="1">MNKNTEYKKITFKEAYSIPNILCYIRILLIPAFIYIYVNAKDTVDYYLAAIIILLSGLTDFCDGFIARKFNQVTELGKLIDPVADKLTQAAIIIALMFKFKWMFFLVVLFVIKELSMLINGIILLRKGKKLDGAMWFGKVSTAVFYFSTFIIISFPMLNSMVVNILMVISAFFMALSFIMYMIEYVKMYKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJP4</accession>
    <name>A0A174AJP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263832.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88931">
        <property type="protein sequence ID" value="CUN88931"/>
        <property type="gene ID" value="ERS852471_00629"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="207" mass="24176" checksum="FF77CFA40D066DA1" modified="2016-09-07" version="1">MAVKKNNDYFEMLVDLIGYSCEAASLLDNTISNFRMSQIDSRIKDMHKIEHNADIKKHEMINKLSKEFITPIERGDIIELANEIDNVTDAIEDVLVRIYMFNISVMREEAVEFSKLIVKICNETSALIKEFRNFKKSSEIRKLIINISDLEEEGDRIYTRSIRGFYSSIMEPIKFITWKETFEYFEKCCDACEHVADGIESVIMRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALD6</accession>
    <name>A0A174ALD6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 1</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bglH_2</name>
        <name evidence="6" type="ORF">ERS852471_00617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263808.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88246">
        <property type="protein sequence ID" value="CUN88246"/>
        <property type="gene ID" value="ERS852471_00617"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN88246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="469" mass="54037" checksum="128871A1F6FAE1ED" modified="2016-09-07" version="1">MYRFPEGFLWGGATAANQFEGAYNEDGKGLSIQDLLPKGITGPMTEEPTEDNMKLIGIDFYHRYKEDIKLFAEMGFKTFRMSIAWSRIFPNGDDLEPNEKGLEFYDNVFDELAKYGIEPLVTLSHYETPLHLAREYNGWTDRRLIGFFERYVRTVFTRYKDKVKYWLTFNEINSALHFPIMSAGILTPKEELSKQDLYQAMHHELVASALAVKIGHEINPEFKIGCMILGIPNYPLTPNPSDIIKAMQEDRGTLFFGDIHARGEYPRYMNRYFKENNIEIKFEEGDAEILKNTVDFISFSYYMSSCATADPELNKKGAGNLIAGVPNQYLEASDWGWQIDPQGLRYILNYYYDRYQKPLFIVENGLGAKDELITDENGNKTVNDDYRIQYLNDHLVQVAEAIEDGVELMGYTTWGCIDLVSASTAELRKRYGFIYVDRNDDGTGTLERYKKKSFDWYKEVIATNGGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0B6</accession>
    <name>A0A174B0B6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_00692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263958.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94501">
        <property type="protein sequence ID" value="CUN94501"/>
        <property type="gene ID" value="ERS852471_00692"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="216"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="511"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="545"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN94501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="756" mass="83492" checksum="524AE2F46915CE82" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0M8</accession>
    <name>A0A174B0M8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN93769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263938.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93769">
        <property type="protein sequence ID" value="CUN93769"/>
        <property type="gene ID" value="ERS852471_00679"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN93769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="20430" checksum="80F3A18FB91868FE" modified="2016-09-07" version="1">MIYLMLFYEFFKTGLFAVGGGMATLPFLDAMALKTGWFTQAQLVDMIAVSESTPGPIGVNMATYVGFTSAGPLGSVIATLGLIAPSIIVILIIAKFLSKFKDSHIVKSIFYSLRPTSTALIAAAGVPVIMLSLTNSDKFKATGSILDLFNFGAILLAIILFILTNKIKATKKLHPVVFIAASAVIGIIFSMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2X3</accession>
    <name>A0A174B2X3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SoxR</name>
        <name evidence="2" type="ORF">ERS852471_00702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263979.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95242">
        <property type="protein sequence ID" value="CUN95242"/>
        <property type="gene ID" value="ERS852471_00702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="41065" checksum="09EC6B03D6A8A2CA" modified="2016-09-07" version="1">MKLQKVLELTKLSKKAVYFYIKEELIEPTKNIDNGYYEFSEEDLRKLQIIISLRNIGMSIQDIKDLFIYPTLTNFFIHRQINNLKKSLYDNIRQLQASYQLIEDIPANATPKNLEIHLHILEKQRISNDLVLEKYFPNIDSRMISILLCAPFTDIESSEYHNFLLDKISNELKLQLENNLSYLKKLIYLLAPEQIDRICIEQYKFSKKIANIKDEEINVYEEELYADCVDLSNNVELQNYWKLVYNPILMPTLNFFINKGMRLLEEYNPVFKRYSDNMKKIAERVYIRLKENEELLNKLNATLDNKLDIEIFNHSQLVCIYTFRDSIFTQVKLEVLKELLNEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3T8</accession>
    <name>A0A174B3T8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pipB2</name>
        <name evidence="1" type="ORF">ERS852471_00706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263985.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95487">
        <property type="protein sequence ID" value="CUN95487"/>
        <property type="gene ID" value="ERS852471_00706"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="24409" checksum="81E71BB9BBFA058E" modified="2016-09-07" version="1">MARNNSAKGNFHYNKVEKMNKNFMYNNLARSNCYASSFAGSNFNFVSFRGAHFKSCDFYGCTFKGAEFIGTNLKNSKFRHAKFENTIFEEVNLDNVDFRDAEFKDVIFVGCDLSKCTNMGIDALNITIFDEIPELNISEELEAAINKAMTNKYIKASRVLDTKEGKINPVKIYLLEKQFTEEELIKGFNDMIEEIDREFHTLSYLLRFFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBS4</accession>
    <name>A0A174BBS4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid protease GluP</fullName>
            <ecNumber evidence="7">3.4.21.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gluP2</name>
        <name evidence="7" type="ORF">ERS852471_00755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264071.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98217">
        <property type="protein sequence ID" value="CUN98217"/>
        <property type="gene ID" value="ERS852471_00755"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN98217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="326" mass="37048" checksum="B17A9CD8ECEE35D6" modified="2016-09-07" version="1">MKKFEDKFFNILINRYGFYIKDYFSSSKNENRWVAISENENYAYAVIVCDEMEATLLYSEAYESLKKVFTKPIALNVVITTKSNEVAQEYLGQYNKLIYSLSEERVLYSGDGCKPLLQVYEYMSKKEQKHRNRFKDNKLTYILIGINVLIYILTAIMSRDVFNSNTYVLIRLGAKVNELINRGQVWRLLTCAFLHGGIMHLVFNMYALKIIGSEVEYVFGRKKYLIIYLMAALGGSLFSYILSPYSISVGASGAIFGLLGAMLVFGVKHRDKIGKSYMMNIIQVIIINVIIGVSLSNIDNYAHLGGLIIGGITALIVKSNLEKSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHU5</accession>
    <name>A0A174BHU5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="1">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yloB_2</name>
        <name evidence="12" type="ORF">ERS852471_00773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="7.2.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264103.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99208">
        <property type="protein sequence ID" value="CUN99208"/>
        <property type="gene ID" value="ERS852471_00773"/>
    </dbReference>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN99208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="859" mass="94941" checksum="CE194B05A0ABA8B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUU7</accession>
    <name>A0A174BUU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1696)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264290.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04397">
        <property type="protein sequence ID" value="CUO04397"/>
        <property type="gene ID" value="ERS852471_00872"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1682253at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012544">
        <property type="entry name" value="PHb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08000">
        <property type="entry name" value="bPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO04397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="125" mass="14066" checksum="6BF4D4FA87F031E4" modified="2016-09-07" version="1">MGLFNGIIGNASEVDINKLAQDYDKLLGPSERIEKAYKLIRDMIIFTNKRLIIVDKQGVTGKKTEYRSVPYRAITNFSVETAGHFDLDAELKIYISGMSMPIEKTFSSGCNIYEVQAILAEYCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2C5</accession>
    <name>A0A174C2C5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cutC</name>
        <name evidence="3" type="ORF">ERS852471_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264362.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07274">
        <property type="protein sequence ID" value="CUO07274"/>
        <property type="gene ID" value="ERS852471_00900"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728422at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="22381" checksum="D8E99DE625AE7CA0" modified="2016-09-07" version="1">MAIYEACVGNYIEAIEAEKRGANRIELCDNLMQDGTTPSYGTIKLAVEKTNIPVMVIIRPRGGNFEYSSDEVEIMKEDIKVCKKLGAHGVVIGALKEKEIDLETIEALLEECEGLSVTFHMAFDEIDDKYKAIDKLAELGINRILTKGGKANAIEGKDELKAFSEYANGRISIMPGKSVTKENRDYLLEYTNTVEIHGSKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2I1</accession>
    <name>A0A174C2I1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">haeIIIM_2</name>
        <name evidence="9" type="ORF">ERS852471_00885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264334.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06499">
        <property type="protein sequence ID" value="CUO06499"/>
        <property type="gene ID" value="ERS852471_00885"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO06499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="376" mass="42349" checksum="521CE089A9AC758E" modified="2016-09-07" version="1">MSTEDNKSLKVIDLFCGCGGLSHGFLDAGYNVVIGVDHDEAALKTYSKNHKDSIALKADLFKDEAIDEIKEKYIDKTGSEEVDLIIGGPPCQGFSLTGSRDINDTRNTLYLAVVKSVNKFKPKAFLIENVPGIATLYGGTVKEQIINTFEDMGYRVSVTDKPLIAADYGVPQIRKRMFFVGIREDIAERIGEKFTFPQPTHMPVNHVTCKEALSDLQSREDELGTEIDEYINEPNSEYQRIMRKNSLKLYNHVATKHTELVKNTIALVPDGGNHKDLPEGVGGSRKFNEAWTRYASNKPSRTIDTGHRNHFHYKYNRVPTIRENARLQSFPDDFIFLGTKTQQNRQVGNAVPPLLAYNIAKELKTYLEKGDNNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4C2</accession>
    <name>A0A174C4C2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06546">
        <property type="protein sequence ID" value="CUO06546"/>
        <property type="gene ID" value="ERS852471_00886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="226" mass="27080" checksum="ED5A2078016DDB05" modified="2016-09-07" version="1">MKIFKSIINIILILIIFVCGYKVFYKVTEYKKADEVYEKIRIEKEETNNPYIENTDYRGWIKIENTNINYPILQGEDNLYYLDKDINKEYIISGSIFMNYLNNGFDDQNTVLFGHNMKNETMFAHLKKYKEKDFFYNNNDIDIELNNGEHLKYKVFSVYITDVTDNYIQTNFENKNEYKDFLERIQSKSMYEADIEVNEDDKIITLSTCSFEFNDARMVVHAKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C652</accession>
    <name>A0A174C652_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL-like lipase/acylhydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264399.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08287">
        <property type="protein sequence ID" value="CUO08287"/>
        <property type="gene ID" value="ERS852471_00918"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="40"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="368" mass="41587" checksum="0D573401A7D88873" modified="2016-09-07" version="1">MGRIASEEMLKESLVYRGDTYKVKKVFEKADRGEDITVAFIGGSITQGCNATIHENCYANRTYLWFKNRFPKINVTYLNAGIGATGSIIGVHRVENQVLSKNPDIVFVDFAVNDKDNKYNKIAYDSLIRRILTHNSKPAVVEVFMSTDILGNVQEQQIEIGKRYNVPMVSFRDAIRTEISNGNLKWNEVASDEVHPNDKGHKIISELLINLLESIDRDDDIKGNEDKIIGQPVFGEDYIKGQILNSDSVEVICTKGMVVDTEGFQGFKNGWTIDSDFSSEGNLKLEVEGKNIFVLYKKLIKDTAGSFDVKINGNYIKNINSYFEGGWGDYSETEVLIEGDKKERYTIEFLVDSNNIYKEIYIMGLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8W7</accession>
    <name>A0A174C8W7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enolase</fullName>
            <ecNumber evidence="9">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">eno</name>
        <name evidence="14" type="ORF">ERS852471_00919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
        <text evidence="9">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264401.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08335">
        <property type="protein sequence ID" value="CUO08335"/>
        <property type="gene ID" value="ERS852471_00919"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="13">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="12">
        <location>
            <begin position="142"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO08335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="431" mass="46886" checksum="B5A8E2BBC96CE33F" modified="2016-09-07" version="1">MKNFVEIVDVVARQILDSRCFPTVEVEVYLEDGTVGRAAVPSGASTGIYEAVELRDGDKSKFMGKSVLKAVENVNDTIAEELIGCNVFDQTYIDKILIELDGTNNKGKLGANAILGVSLAVAQAAANYLGLPLYQYVGGVNAKVLPVPMMNIINGGSHADNSVDLQEFMVMPVGFESFDTAVQACAEVYHALKKTLNDKGYATGVGDEGGFAPNLKSNAEAIEVILEAIKKAGYEPGKEMFIAIDAASSEYYKDGKYVLEHEGKTLTAAEMVDFLEDWVNKYPIISIEDGMAEEDWEGWKLLTERLGKKVQLVGDDLFVTNTERLEEGIKKGVANSILIKLNQIGTLTETLNAIEMANRAGYTAVISHRSGETEDTTIADLVVAVNAGQIKTGAPARSERVAKYNQLIRIAEELDDVAEYRGRKAFFNIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGH3</accession>
    <name>A0A174CGH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264495.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10858">
        <property type="protein sequence ID" value="CUO10858"/>
        <property type="gene ID" value="ERS852471_00970"/>
    </dbReference>
    <dbReference type="OrthoDB" id="507759at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="456" mass="53865" checksum="DD194170B49E2EE1" modified="2016-09-07" version="1">MEYNLNDLQEWNVKIEEKAKSFGLDYYPQEFEIIGYNEMIGYEAYVGMPSKYPHWSYGKAYEKNKTLYSLNLTGLPYEMVINSDPCLAYLMRENSLLLQILTMAHVYGHNDFFKNNRLFKEGTKAYYTLEMFKLDAEIIRGYVNDPNIGYAKVEKILDAAHALKFQIPRVVGVKELSQEEIKANLMNEYNRKIEGRYVLDQDEEIELPDLNKIPLEPCDDVIGFIIKYGYLEEWEKTVLKIVKRETEYFMPQIETKIMNEGWASYWHYTILNSLELPEGLHFEFLKRHNDVIAPILGGLNPYYMGFKIFQDIEKRYGREKLFEVRSLERDNSFLRKYLTQDLCNELNLFQYAKKSFDFVIEEVSDDEGWKIIRDTLSSTCGVGGIPYIRIVDLDRKDGTLTLEHVFDGRELELLYAKETLKYLFDLWGRKVLLKTKTREGKNIEILCDNDRKIYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIZ8</accession>
    <name>A0A174CIZ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11930">
        <property type="protein sequence ID" value="CUO11930"/>
        <property type="gene ID" value="ERS852471_00992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="30726" checksum="27E57CC3AC6A7A6B" modified="2016-09-07" version="1">MHFNIMDRKIVFFDIDGTLIDENTLIIPESAKKALKEMRSNGHLAFINTGRTACQIESLKSKLEFDGFICGCGTYVEYEDKVLLHKSLGNELTSKLVKALKKYHIDGVLESIDGVYYDNIEAIRHPEVFKVLNIHKSEGSYSGKTWYEDGLNVDKLVIFLNNDSDFDGFFNEFKDVFDFIKRADDFYELVPINYSKATGIQFIIEHLGIPFENTYAIGDSANDLTMLKYVNNSIAMGNSNPILFDLVKFVTKDINDDGIEYALKHYEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CQD0</accession>
    <name>A0A174CQD0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylation/crystallin J1</fullName>
            <ecNumber evidence="1">3.2.2.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">draG</name>
        <name evidence="1" type="ORF">ERS852471_01039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.24" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264574.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15761">
        <property type="protein sequence ID" value="CUO15761"/>
        <property type="gene ID" value="ERS852471_01039"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047407">
        <property type="term" value="F:ADP-ribosyl-[dinitrogen reductase] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="38342" checksum="01BF90CD68BF04F3" modified="2016-09-07" version="1">MRKTKVYYRGCLVGGAIGDALGWPVEFMSLEEIKSKYGKNGINNIIIGRRGRAEITDDTQMTLFTAEGLLRGETRGYNKGVSDSNKCIYNAYLRWLYTQGDPADDDLNIYDGYLIKQKELYVKRAPGMTCLTSLRNRELGTIDNPVNDSKGCGCVMRVAPVGLFYRPNFAFNKGMECAAITHGHITGHLSAGAFAYIISSIISGMDIVHSVEDALIELSKYYNSEDVIDILKKAINLSISKKSNEICIKEIGQGWIAEEALAIAVFCALRYKDDFEGAIIAAVNHSGDSDSTGAMTGNILGAHLGLNKIPRKWTSKLELYDVITKVADDLLTGYSDEGDWWMKYPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CW21</accession>
    <name>A0A174CW21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17562">
        <property type="protein sequence ID" value="CUO17562"/>
        <property type="gene ID" value="ERS852471_01076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="40" mass="3694" checksum="3DA18877455BC6BC" modified="2016-09-07" version="1">MDVITVAVVVAIDVVAGVITATAVVAGVTASVAVSVAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZ83</accession>
    <name>A0A174CZ83_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yccS</name>
        <name evidence="2" type="ORF">ERS852471_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18367">
        <property type="protein sequence ID" value="CUO18367"/>
        <property type="gene ID" value="ERS852471_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="588" mass="68485" checksum="7BBFBB445EAD337A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DDJ9</accession>
    <name>A0A174DDJ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264678.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22006">
        <property type="protein sequence ID" value="CUO22006"/>
        <property type="gene ID" value="ERS852471_01164"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2083130at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO22006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="171" mass="19601" checksum="E755E09099399D33" modified="2016-09-07" version="1">MKKSKRVKNNCKDSRNLNRKLANEKNDYSKEKSSSSDTSSSSTESKVNYEELIAQINQLNLSFDTLLIILTAILLNIYYVYYTRTQALDTLNNTKYADLLIDGTKLPRITNAMFLYATAIFLEINYSNYENLNSVQGEERNCKEINKAYRAFFSTLLVLIATAMSRSNLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DL89</accession>
    <name>A0A174DL89_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="6">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ywqD_1</name>
        <name evidence="21" type="ORF">ERS852471_01202</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CpsD/CapB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO24895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264722.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24895">
        <property type="protein sequence ID" value="CUO24895"/>
        <property type="gene ID" value="ERS852471_01202"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="18">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="20">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="19">
        <location>
            <begin position="275"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CUO24895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="446" mass="49199" checksum="0AEBC80B9E0752E8" modified="2016-09-07" version="1">MNKFKYFKLIKEKLSIIILITISSIIISTIATLFFIEPTYESKISVIIGPNQSTSGDYSSSQSSYDVVMYQKMVKTYSELLTSKIVLQDVIENTGLDLNLESLESMIKIKTTTESEFINITVEGKVPEVTTLVANQLTLSLKNISSEIRGVDNVILVDSASIPEKPTKPNIIINISLSFILGLIFSISLVVLINYLDQRIKDKDELKELITFPILGEIPDFSSVNINNKGNYLFVNESPKSLPSEAINILRTNLQFCNVNYNLKKILITSSSPSEGKSTIISNLGISMALTNKKVIIIDCDMRKPKIHRIFSLSNIIGLSHILSNQAELEECLQSSGINNLSILTAGVIPPNPSELISSNGMKILLDRLTSNFDFILIDSPPLPLVADSQALSTFVDGTIIITKLGYTTKSALLNTKEILDGLKTNVIGVVLNNSPLDSSVNYYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DN52</accession>
    <name>A0A174DN52_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU_1</name>
        <name evidence="6" type="ORF">ERS852471_01213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264732.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25436">
        <property type="protein sequence ID" value="CUO25436"/>
        <property type="gene ID" value="ERS852471_01213"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO25436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="32678" checksum="5AE8906CF4E8BD98" modified="2016-09-07" version="1">MENRIKKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPTLQYIIEECVEAGIEEIIIITGRNKKSIEDHFDKSVELELELARTGKDDLLTMVQNISNMANIYYIRQKEPKGLGHAIYCARAFVGNEPFAVLLGDDVVYSEEKPCIKQLIDCFNKYNKAILGVQKVPANEVFKYGIISGEEIEKRVYKVNSMVEKPDINKSPSDMAILGRYIITPDIFNILENTKPGKGGEIQLTDALSMLIEKDGVYAYDFIGKRYDIGDKLGFLQATVEYALRNSELKEEFIKFLLSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNA5</accession>
    <name>A0A174DNA5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">polA_1</name>
        <name evidence="11" type="synonym">polA</name>
        <name evidence="15" type="ORF">ERS852471_01246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264777.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27112">
        <property type="protein sequence ID" value="CUO27112"/>
        <property type="gene ID" value="ERS852471_01246"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="627"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO27112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="870" mass="99322" checksum="98EE0BCF5EFBCA8A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSY1</accession>
    <name>A0A174DSY1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264825.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28337">
        <property type="protein sequence ID" value="CUO28337"/>
        <property type="gene ID" value="ERS852471_01272"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1343945at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="287" mass="33762" checksum="BB26751CBD45C593" modified="2016-09-07" version="1">MNNEKNKKLYMAISVIIIFILLIFIIITLKNIYGNSSKQIKESYDFLYELEKVDAISEMDRMSINEFQEIKKVSDFANVKYTIVNNNYVIELNDEYKVIGFFEQNVRKIYNVDKLTVKDCKEYAKKYLNKIYKGEVTFKEVKDKNLDENPFYTMVYYKMNNGYICYSNEIVIKINKYDGTLVGYSNYSGNDEKFLSNIYITEEDSKNIFNNYMKELGLEGEIVSNPKIGYFNIDGEANQICYIIIYKMIEKDNNVKFNDIVINAETGEIVKHIINIIELIYGEDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXB0</accession>
    <name>A0A174DXB0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rnz</name>
        <name evidence="10" type="ORF">ERS852471_01311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264897.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30191">
        <property type="protein sequence ID" value="CUO30191"/>
        <property type="gene ID" value="ERS852471_01311"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="35133" checksum="68E26D597F2B654F" modified="2016-09-07" version="1">MVDIAMLGTGGGMPMVERYLSAALINFKGRKILIDSGEGTQVSMRILGWGFKNIDVICITHSHGDHIVGLPGLLATIGNSGREEPIIILGPKGIKDVIQGLRVICPYLPYELIIIENPYNIKLSVKKDKISFEDRFEGDIVINSLELEHSSPCIGYNFYINRKPKFDVDKAVRNKVPKNLWSLLQKEEIAKENNIVYTKDMVLGDIRKGIKISYITDSRPIESIIRFISDSDLFICEGTYGSDEDRDKAIKNKHMTFAEAATLAKEGMVKELLLTHFSPSLLQPSMYLNNATNIFNNTVIAHDRIIKTIKFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXP1</accession>
    <name>A0A174DXP1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plant auxin-responsive GH3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264901.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30273">
        <property type="protein sequence ID" value="CUO30273"/>
        <property type="gene ID" value="ERS852471_01313"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566369at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO30273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="558" mass="64570" checksum="95FFEEE62975632B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6Q8</accession>
    <name>A0A174E6Q8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ORF">ERS852471_01360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264985.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32136">
        <property type="protein sequence ID" value="CUO32136"/>
        <property type="gene ID" value="ERS852471_01360"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="32202" checksum="E8E33D1408B57D22" modified="2016-09-07" version="1">MTKIVEKSKIWFSISLIVIVVGLGFMLTKGLNFGIDFKGGTKLVIDFGKEYNKPEVDEVVKAIVPDAVTKTVEDTQYEIKDRDLDETKTTELFDKLKETYSLEDTALLSQTQVGASVGRELTRNSIIALFVACIAMLIYLAIRFKMDYGIAAVIALLHDVLITISVYAIFNIPVNTPFIAAILTVVGYSMNDTIVIFDRIRENTKTMRRATSAEIADKSISQTLGRSIKTTITTLFAIGAVNLFVPTVREFSFPLLIGITAGAYSSIFIASPIWVKLRDGNKHKNKRGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E8V4</accession>
    <name>A0A174E8V4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ORF">ERS852471_01372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265009.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33787">
        <property type="protein sequence ID" value="CUO33787"/>
        <property type="gene ID" value="ERS852471_01372"/>
    </dbReference>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="416" mass="45660" checksum="3130F0487D7E858E" modified="2016-09-07" version="1">MKILLVGSGGRESAIAFKIAQNEKVSKIYVAPGNGGTALYEKCENLNITDIDELLSFAKENNIDLTIVGPEEPLTKGIVDKFRSEGLRIFGPDKKGAELEGSKSFSKDFMKKYGVSTAEYEVFYDAEEAKAYLETCSYPIVIKADGLAAGKGVVICEELNTALDTIDLFMVQDMFKGAGRRVVIEEFLVGIEASILSITDGKTIIPFLSAKDHKQIFDGNKGPNTGGMGVVCPNPYVTDGVLKDFYENIMDKTLMGIREEGMDFKGIIFFGIMITEKGVKLLEYNVRMGDPETQSVLTLMKTDLLDLIEKALDEKLEDSEVEWEEGYCVNVVLSSKGYPDKACTGYEIEIDNTELSNVFVAGAKLEEGKLITNGGRVLSVVGKGRTLEEAREAAYKIREKVNFEGAYCRSDIGIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGW1</accession>
    <name>A0A174EGW1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265131.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36941">
        <property type="protein sequence ID" value="CUO36941"/>
        <property type="gene ID" value="ERS852471_01445"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2066664at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO36941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="61" mass="7154" checksum="C7E8B05D0C9643B2" modified="2016-09-07" version="1">MKESNLKLAQRDIEEALKTVEEMEEFVDTIDAPKEVLKEKFYTLTQKVQQLEDILKNEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHF5</accession>
    <name>A0A174EHF5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative septation protein SpoVG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">spoVG</name>
        <name evidence="5" type="ORF">ERS852471_01410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be involved in septation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SpoVG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265069.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35390">
        <property type="protein sequence ID" value="CUO35390"/>
        <property type="gene ID" value="ERS852471_01410"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1871825at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00819">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007170">
        <property type="entry name" value="SpoVG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036751">
        <property type="entry name" value="SpoVG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38429">
        <property type="entry name" value="PTHR38429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04026">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160537">
        <property type="entry name" value="SSF160537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="93" mass="10468" checksum="C7736D5E675DB2BA" modified="2016-09-07" version="1">MTITDVRIRKIATEGKMKAIVSVTFDNEFVVHDIKVIEGQNGLFIAMPSRKTPDGEFKDIAHPINTDTREKMQSSILAAYEEAMQEDVNVVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EL55</accession>
    <name>A0A174EL55_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yedJ</name>
        <name evidence="2" type="ORF">ERS852471_01451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265140.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37159">
        <property type="protein sequence ID" value="CUO37159"/>
        <property type="gene ID" value="ERS852471_01451"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="217" mass="24944" checksum="6D5090964A1F95C0" modified="2016-09-07" version="1">MDKNKMIKNTKDFVKEKLYGKCSGHDWFHIERVYNLAKFIGEKENADLFIVEMTALLHDIDDWKFSDGTETNTTVTENFLNSIDVSKDDINKIISIIKTMSFKGGVVDSTQISIEGKVVQDADRLDAIGAIGIARTFAYGGSKRRPIYDPSVAPINFESLEQVKNLENHTVNHFYEKLLKLKDLMNTKTAKEIAKKRHEFMESFLDEFYSEWNFPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENC0</accession>
    <name>A0A174ENC0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4351 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265210.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39001">
        <property type="protein sequence ID" value="CUO39001"/>
        <property type="gene ID" value="ERS852471_01489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025587">
        <property type="entry name" value="DUF4351"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14261">
        <property type="entry name" value="DUF4351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4351" evidence="1">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="9133" checksum="9B408F41F0008B24" modified="2016-09-07" version="1">MNLSYSLRAYEEGMADGIKEGHFSLLIKLLKKKFKHIPEKYIDLLTDLENDTIISIALRIFEFETLEDLDVFLLVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXN1</accession>
    <name>A0A174EXN1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265288.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42067">
        <property type="protein sequence ID" value="CUO42067"/>
        <property type="gene ID" value="ERS852471_01529"/>
    </dbReference>
    <dbReference type="OrthoDB" id="842200at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO42067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="359" mass="40955" checksum="5F33035AFF37C131" modified="2016-09-07" version="1">MSKLSAKHFVLFIFGVTFISFKTYSSLFIAEGGRDTWIYTIIAYIVFLAFAMYLIYIMDSRKTYDLTQIFTLGLSKTLGNILLFIFSIGLFLAALESATVEANAIKTNFFIETPVWYILIFFLLPSFFIIGKKFTTLLIFVILTSGSLILNFINLSLVTEKYKHMKYILPVFGNGIGIELINTSLLIIGSLSAFVIALPFLKYLNKNNKLKKHSLIALAIVGFICIYSIIGTLATFGPLRASNIFYPEYVQSQLVQIGGFLEFGEFFFVFQTVIGMFVKYIIATCGIYLIYEKQIKSRKAFITIYSIAIFIFACFLSRNNYTLFNVLKYYQYINLVTFVLVPLIAFLSFQINVHKIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F403</accession>
    <name>A0A174F403_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IstB ATP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265346.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43526">
        <property type="protein sequence ID" value="CUO43526"/>
        <property type="gene ID" value="ERS852471_01557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="122" mass="14213" checksum="8FCE693E23AE4F54" modified="2016-09-07" version="1">MASKIQISVAGFSFVKRSDEYNYKFRSSANRSKIQYLCLLRFIKKKENILSYGTTGIVKTHLATSIGIEATSKRYLTYFISCHDLIQNLRNAYNENRLEAMLKHYNKYKVLIIDEIGYLPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F650</accession>
    <name>A0A174F650_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265436.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45723">
        <property type="protein sequence ID" value="CUO45723"/>
        <property type="gene ID" value="ERS852471_01604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="176" mass="19684" checksum="8DDE20EE2AC85D21" modified="2016-09-07" version="1">MKCDFGIKLKEELIGGLSTSKAALEMELISEDKYNIFYDRVSRKSGFSDYVEKASDVACAQICCLVGIEMEKGDGYKEGKIILNPTDKNGNRFCDVIMVSKKNIHAMKIVSMECDFIEVDEYEEMMEIAYKAVDEYLCETSSNSIDLTVIQPNLLTSSSGTANVDDVLDAFDKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHH2</accession>
    <name>A0A174FHH2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265483.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47880">
        <property type="protein sequence ID" value="CUO47880"/>
        <property type="gene ID" value="ERS852471_01630"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2180904at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="118" mass="13465" checksum="7E98E53570B747F1" modified="2016-09-07" version="1">MEKDQENLVEKELEQILTEEEVENVAKEEVYEEVVTVEGKFSHYFKVILAGCLDQILAVGIALILFVVFDLILGVLGYKIAMRDEVFLIVFIISNVLYYPISQEILQGKTVGKKIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FK29</accession>
    <name>A0A174FK29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Penicillin-binding Protein dimerisation domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">penA_1</name>
        <name evidence="7" type="ORF">ERS852471_01652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265526.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48969">
        <property type="protein sequence ID" value="CUO48969"/>
        <property type="gene ID" value="ERS852471_01652"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="6">
        <location>
            <begin position="58"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="5">
        <location>
            <begin position="425"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO48969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="983" mass="110506" checksum="FD8E1AE2D4FC85B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKB4</accession>
    <name>A0A174FKB4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mreC</name>
        <name evidence="8" type="ORF">ERS852471_01654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49049">
        <property type="protein sequence ID" value="CUO49049"/>
        <property type="gene ID" value="ERS852471_01654"/>
    </dbReference>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO49049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="31521" checksum="F552287204134812" modified="2016-09-07" version="1">MKPFKNKLAVTIIVLSVTFLGIIIFSVKNGSDSISSGIGAVVSPLQKIVYKANDKLKSSVEFFVNFSKVKQENEELKIKNSELENQMIEYKALKDENERLREVLNFKENKNNYDYIGVNIIGYSGGTVSNGYIIDKGTNDGVEKDMIIINYQGLVGKVTKAESNYSIVETILNENMAVSVMVDSTRETTGILRGYKENKNEDLVKVYNLPIDSEIKEGDVILTSGLGMIYPKEIRIGEVVSVETDNVMVMKNALVKPYVDFNKLEELFIVVPKDKVNVKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKJ0</accession>
    <name>A0A174FKJ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywaD_2</name>
        <name evidence="3" type="ORF">ERS852471_01689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265591.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50782">
        <property type="protein sequence ID" value="CUO50782"/>
        <property type="gene ID" value="ERS852471_01689"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="215"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO50782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="447" mass="50666" checksum="F696461102798BA0" modified="2016-09-07" version="1">MRKKLIYLLSLSITFILLFFLILLNYSYSDFDSSNVKETISLLSSETYNGRLAGSTENAMVADFIENKFRESNLKPYGDDSYKKDFDTICPVYTNTTPYLKILSNGEVEEELQYGVDFKEDMINFRGNTFTFSNKDKISSFFLSIEVTTSENKFLFFVPKEEELYFRSSFMSDFPYDAVIMITENTKNKIITSLNEGKEISIHIPFESETKTISNVVGVIEGTDKEAAPLVITAHFDHLGQDGLGNIYGGALDNASGTSFILELQRSLSTFAKPNRDIIFVALNAEEFGLLGSKQFAEENIFNIKNSEVMNFDMVGITGFPITFMQGVDFKDKDSELLNSLEEICKKNNTSYEVLYQDSSDHASFNKLGIDAVSFCHSDLSKIHTPYDSLTYINLDAIDSVYEIVNQKIMDSCYSKFTLFLYNKLLILILSIILGILIGYPLLKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLZ8</accession>
    <name>A0A174FLZ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265548.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49599">
        <property type="protein sequence ID" value="CUO49599"/>
        <property type="gene ID" value="ERS852471_01663"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="299" mass="34924" checksum="A3013AB888AEF396" modified="2016-09-07" version="1">MAFIIIDLEFNNLSGIHKCFPNIYNEIPNLKKLDLVNEIIEIGAIKVDKYMKPMDSLKVYIKPSVIPVLNPNILDITGIKEENLKDGVSFIEGIEKLKEIVDEGDIVCSWAKDDIVEIIRNANHYNYRDISWINKYLDLQEYTTNILGFKKSLSLSNALKHLKIKFDGEKLHDALNDAVYEFNVFKHLYNTRAIEKYIVNNIYEMPALDVETLSDHEIDYDKVKQLCPRCNKKIDCEYPFKLMGWRFVSIGICNRCNNKLLSELIVKRSLGGKIIYQEILSFIDEIEYSRYENRLKDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWV0</accession>
    <name>A0A174FWV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group 1 glycosyl transferase</fullName>
            <ecNumber evidence="3">2.4.1.250</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshA_3</name>
        <name evidence="3" type="ORF">ERS852471_01744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.250" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265688.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53398">
        <property type="protein sequence ID" value="CUO53398"/>
        <property type="gene ID" value="ERS852471_01744"/>
    </dbReference>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="60"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="41912" checksum="FFC40D9043A4041C" modified="2016-09-07" version="1">MNIGIDGRAAKWYRGTGIGTYTYQLISNINKIDNINNYLLFLPQNTDLKLNNNFATKLIEESPNSNFWDEVNAPNILNNTDIDLYHVPQNGVGLAENINCLKTITLHDIIPLRMPETVSDRYLNIFNNQLPKIIENCDGIITVSQFSKNDIAKEFNFPKEKIFVTYLGAEDIYKPLDKKSCKNFLKNRYNIDKNFILYVGGYSPRKNIIGILEAFSLLDPKLRENLYVVITGKKGISYSIYMKRAEDLGIKNSVIFTDFIPLDHLPLFYNACEFLVYPSFYEGFGLPPLEAMACGTPVIASNVTSIPEICSGSALLVDPHDIDALNLSMEELLSDDNLKNSMIKCGLSNCSKYSWLNTAKDTISAYKSIIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXR1</accession>
    <name>A0A174FXR1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group 1 glycosyl transferase</fullName>
            <ecNumber evidence="3">2.4.1.246</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mfpsA_2</name>
        <name evidence="3" type="ORF">ERS852471_01748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.246" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265697.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53626">
        <property type="protein sequence ID" value="CUO53626"/>
        <property type="gene ID" value="ERS852471_01748"/>
    </dbReference>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103011">
        <property type="term" value="F:mannosylfructose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="378" mass="42994" checksum="4927DE1DE55F7B57" modified="2016-09-07" version="1">MNLSIDGRGITLYNGSGIGTYIANLLKELITIDNKNEYTIFWAGDNYDAFKKSNTNIVLTSKRHGMFYENFYYPNYLQSNNIDLHHIPQNGIGLSKDYPVPCVVTIHDLIPYTLPETCGKGYLTRFLKDMPYIIENSKGILTVSEYSKRDILKFFPSFPEDKIFVTPLAANSSFYPMEKDICNSFLKEKYNIDFPFILYIGGFSSRKNVKELILSFNDIYSSLKKKYKLVLCGSIKDEGEKLKEFCKGLRLENNVIFIGFVPDEDLPFFYNGCSLFVYPSLYEGFGLPPLEAMSCKAPVITSNLTSIPEVTKDCALLIDPFNKDELSNSILKVLNSSSLSEELSEKGYSNSKNFTWTKTAELTLQAYESIYKSLNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G039</accession>
    <name>A0A174G039_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tldD_1</name>
        <name evidence="6" type="ORF">ERS852471_01760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265721.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54190">
        <property type="protein sequence ID" value="CUO54190"/>
        <property type="gene ID" value="ERS852471_01760"/>
    </dbReference>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="227"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO54190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="49179" checksum="56A158FB6E815DDD" modified="2016-09-07" version="1">MLSREVAQRVLGRCLITGGDFAEIFEEDTINNTIGILNGKVENSVGGRSYGIGIRIFKGLKSVYAYTNNNSLSSLLNVAYKAALALGEAKEEKNIVLDCTTIKNSHPIIHMPSSIDINKKIGVMKIAYNAAKDYSSEISQVGVNYIDKEQNVLIANTEGLYVEDKRVGTRLAINSVASLNGENQTGFEGPGAHMGFELFNHINPEYYGKEASRIAYTMLHAKNCPAGKMTVAIDNGFGGVIFHEACGHSLEATAVAKGNSVFTGKLGEQIASTKVTAIDDGTIPNAWGSLNIDDEGNKTQKNVLIENGILKSYMIDRLNGRRMGMAPTGSGRRQSYKFAPTSRMTNTYIANGEDSPEEIIKSIKDGLYAKKMGGGSVNPVTGEFNFAVSEGYIVKNGEIQEPVRGASLIGKGSEILMNIDMVGNNMTQGQGMCGSSSGSIPTNVGQPMIRVSEITVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G820</accession>
    <name>A0A174G820_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265790.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57009">
        <property type="protein sequence ID" value="CUO57009"/>
        <property type="gene ID" value="ERS852471_01796"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2174956at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022322" evidence="1">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO57009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="24371" checksum="F1BADD321D8C8EF2" modified="2016-09-07" version="1">MKRISILALIIITMLTIGCSNKNKESIDNNGMYTEEVEKDEEIIEENYTVFNCLDNVYEKNQDITLYEKGEEVFNNLTNNIYETGKYMEVDYANDFIEKYLSGDQSVYNYLITLDDKYDVGYKEANNDEKDRLKESLQFLREQMYLNNEDPIYFRLSKVSYDGQVDGIKDSVILNMTGYISGDNINFLSLSKFTITIVQDKDKLLVNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8U0</accession>
    <name>A0A174G8U0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="5">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="5">UPRTase</shortName>
                <ecNumber evidence="5">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pyrR</name>
        <name evidence="7" type="ORF">ERS852471_01838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer and homohexamer; in equilibrium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265871.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58852">
        <property type="protein sequence ID" value="CUO58852"/>
        <property type="gene ID" value="ERS852471_01838"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1725260at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 5" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="5">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO58852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="178" mass="20012" checksum="64B8B58B171211B3" modified="2016-09-07" version="1">MKLKANLLDQNAIRRSLIRISHEIIEKNKGVEDIVLIGIKRRGYPIANRISENIENIEGIKVPVGYVDITLYRDDISEIMDMPEVKNIDLGVEVKGKKVIIVDDVLYTCRTVRAAIDAIIHAGRPKSIQLAVLIDRGHKELPIRADYVGKNIPTSKSEIVAVEITEIDEDDSVKIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GG27</accession>
    <name>A0A174GG27_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">40-residue YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265976.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61514">
        <property type="protein sequence ID" value="CUO61514"/>
        <property type="gene ID" value="ERS852471_01901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="32441" checksum="B47BD79D7BFC210A" modified="2016-09-07" version="1">MNSILVCNTGADSLSRIILNDLHLEKITFNLGEKPIGPNGIEVYDDGFITTNSYSDSISFFDKKYLKEIKNAKIGPSPNDLIVYKKKVYTICGESNSVVVYDILEDKALYEIATGSWPYSVEADIEKGIAFIANFESNDITVINMDNNNVIKKIDANEYPTKVLLSKDKEFLYVCESYLGHDKSGFLDVISAKTLKSIKRITVGSSPMDVIEGEENIYVSNFTDGTISVINKGNMILQESIYVGGMPKGMITHENKIFVSDYLKGKIYVIENNKINKVIAIESEPNAMTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS16</accession>
    <name>A0A174GS16_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266124.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65492">
        <property type="protein sequence ID" value="CUO65492"/>
        <property type="gene ID" value="ERS852471_01980"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="40"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="22324" checksum="FF34F8C9AF2CC8A4" modified="2016-09-07" version="1">MKISKNKKIIILAMIVLIAIILVANLGNFLIVNDELHKADAIVVFSGDNGPRTEKGVELLKEGLGDYLILSGGIVYDDVTMAELMKNHAIKLGVPKEKILIDDKASTTHENAEFTKEIIEENNFKSIIVVTSEYHSRRSKLAMEKVLKNTSIDGQQVKVMIAHATEEKFTTKWWTSGNSILILISEYLKLMGYWTKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSB3</accession>
    <name>A0A174GSB3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fieF_1</name>
        <name evidence="8" type="ORF">ERS852471_01940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266052.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63916">
        <property type="protein sequence ID" value="CUO63916"/>
        <property type="gene ID" value="ERS852471_01940"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="232"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO63916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="392" mass="43368" checksum="EF502EA47895C4E5" modified="2016-09-07" version="1">MITNYLIKTFVKDNEKVDNIKVRNAYGNLAGAVGILVNVLLFAIKLSVGLLAGSVAVMADAFNNLSDAASSIITIIGFKMANKPADAEHPFGHGRIEYISALIVSFLVMLVGLQFIKSSFERITNPSIVKFEVIPFLLLLVSIFFKLWLSKFNKTVGHKINSSALKAAATDALGDVFTSSTVVISFLLAKFTQFPLDGYIGVFVACAIIYSGYGLIKETLNPLLGEAPDPVLVNNISDMVMSYENINGIHDLVVHNYGPGRIMASIHAEIPSDIDVMTIHHIIDTAEREISKKLNIYLVIHMDPICVDTDEIIDARKIVEDVLKTYPAVKSLHDFRVVGENDIKNLIFDIVVNPIDLNDCFTKEKLSQFIERDIKKLHPQFNCIITVDLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSP4</accession>
    <name>A0A174GSP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livH_2</name>
        <name evidence="7" type="ORF">ERS852471_01949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266070.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64277">
        <property type="protein sequence ID" value="CUO64277"/>
        <property type="gene ID" value="ERS852471_01949"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO64277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="325" mass="35090" checksum="C9B1DFE56E593362" modified="2016-09-07" version="1">MKKYRSQIIMIILVFGAFFIINSLIGANIINRYITRLMILSCINIILAISLNLITGITGQLSLGNAAFMAIGAYVSAFFSVNLGMPFVVSLIAGAITAAAMSIIVGIPTLKLKGDYFAITTLGVCEIVRVLITNMDIVGGARGFTGIPKKTTFTIAYFAVVIVIVVVVNIVKSTKGRAMLAIRENEIAAEAMGVNTTKYKVVAFFISALIAGFAGGLFSHYTAFIQPTTFNFLKSIEIVTFVVLGGMGSITGSVIAAIILTILPEALREFADLRMIFYSITLVVLMIFRPQGLLGTLEITDLIEKFKNKRKIKKQNKATTIASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7F3</accession>
    <name>A0A174H7F3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase/6-phospho-beta-glucosidase /beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglH_4</name>
        <name evidence="3" type="ORF">ERS852471_02087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266324.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70161">
        <property type="protein sequence ID" value="CUO70161"/>
        <property type="gene ID" value="ERS852471_02087"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO70161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="484" mass="55317" checksum="8A0073DC9462F12A" modified="2016-09-07" version="1">MSNIKFPENFLWGGATAANQFEGGYREGGKGLSTSDVMTGGTHTVARRITPELEEGTYYPSHEAIDFYHRYKEDIALFAEMGFKTFRMSMNWTRIFPNGDELEPNEEGLKFYDDVFAELKKYNIEPLVTISHYETPFGLTKKWNAWEDRRTIDCYLRYCETIFNRYKDTVKYWLTFNEINILTHGAAAAFMGAGVMFDDIRELKFGPEAAGHKQECFQALHHQFVASAKAVQLGHSINPDFKIGCMIAYGKQYPYTCNPEDVLLAQQSEEFSNFLCGDVQVRGAYSGFAKRYFRENNIEIKMEEGDLETLKNGCVDFYTFSYYMTNCVSKDPNVETTGGNLSMGLKNPYLEASDWGWQIDPVGLRTTLNQIYNRYQIPMMIVENGLGAVDTVEADGSINDDYRINYLKAHIEQMKEAIADGVELWGYTPWGCIDLVSAGTGEMKKRYGFIYVDKNNDGTGTLNRSRKKSFYWYKNVIATNGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HA59</accession>
    <name>A0A174HA59_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266385.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71804">
        <property type="protein sequence ID" value="CUO71804"/>
        <property type="gene ID" value="ERS852471_02118"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO71804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="32034" checksum="E2B4FE895BD88688" modified="2016-09-07" version="1">MSFLTLGITALSAYGFCYYQNNKIQITRFNIDSSSNDNIKVLQLSDLHSKEFGKDNKILKDIIFNEKPDIVVATGDLIDSNMKRIDKIISFLAEVNNNIPVFYIPGNNEMRCKRINEILHKLRANNVVVLDNEIKTIKIKSTIINILGLVENRIDSGELFYEKVKSKYEGQKSELLLKKLENMNGLKFVLSHYPENYDANEDTLYSRHNFDIMFSGHAHGGQFILPFVGGLFAPGQGILPKYYSGMYGESNKLIVSRGLGNSGFPLRLFNRPNIVVVDILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCK0</accession>
    <name>A0A174HCK0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266419.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72613">
        <property type="protein sequence ID" value="CUO72613"/>
        <property type="gene ID" value="ERS852471_02136"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1426624at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="29121" checksum="FA6B578B61706EBD" modified="2016-09-07" version="1">MNWIINFFKGIAISVATMVPGVSGGTMAIILNVYDDLIHAVGSFFEDWRKHSKLIFQLALGGIVGVLAFSRIIDKALDKFPTLMAFFFIGVILGGIPTLYRKAISIEKSNFNYIFLIVGFVLALFLSGNNEVASIAIESTGIFNIGLLVLAGIIIAVALILPGISGSFILLILGLYDVTLDAINTFNIKFLIPVGIGVLIGVVLTTKIIEKLIKKYPGKTYMMILGFVVGSIIAIYPSEATNTNIIYSILALIIGFIIIYFISKKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHI4</accession>
    <name>A0A174HHI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266417.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72580">
        <property type="protein sequence ID" value="CUO72580"/>
        <property type="gene ID" value="ERS852471_02135"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053784at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="82" mass="9659" checksum="DDFD6C50DFA95BFD" modified="2016-09-07" version="1">MRDITNSKGKIFRHFKGDLYLVEDFVKHSETQETMVLYRALYGECGLFVRPYGMFVEEVPEGKVNPTGQKYRFEEFNVKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HV05</accession>
    <name>A0A174HV05_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS system mannose/fructose/sorbose family transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">manX_3</name>
        <name evidence="9" type="ORF">ERS852471_02251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266616.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76675">
        <property type="protein sequence ID" value="CUO76675"/>
        <property type="gene ID" value="ERS852471_02251"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696140at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00001">
        <property type="entry name" value="PTS_IIB_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018455">
        <property type="entry name" value="PTS_IIB_sorbose-sp_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00854">
        <property type="entry name" value="pts-sorbose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-4" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="161" mass="17930" checksum="183E4096F70C75B8" modified="2016-09-07" version="1">MKIGLARIDDRLIHGQVVTVWTKECKCQRIIVCNDEVANDNLRKTLLTQVAPPGVKSHVVSIDKAVRVYNNPTYANDTVLLLFTNPTDVVRLIDAGVDIKSVNIGGMCFKEGKKQLTTAVSVNEEDVKAFRYLDSKGIELEIRKVASDSKTNIMPLINKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HV89</accession>
    <name>A0A174HV89_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thymidylate synthase</fullName>
            <shortName evidence="4">TS</shortName>
            <shortName evidence="4">TSase</shortName>
            <ecNumber evidence="1 4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">thyA</name>
        <name evidence="6" type="ORF">ERS852471_02301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 4"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78892">
        <property type="protein sequence ID" value="CUO78892"/>
        <property type="gene ID" value="ERS852471_02301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="5">
        <location>
            <begin position="13"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO78892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="32859" checksum="88E58E74A9476E09" modified="2016-09-07" version="1">MTKNFISKTDELFKNTLNEILTNGTSTEGHKIRPKYKDGTPAHTLYINQVVEKYDISKGELPITTLRPTAWKSAIKEILWIYQDQSNDLSVLEEKYGIMWWRDWEVNNSNTIGQRYGATVRKYDLMNKLLKGLKNEPYTRRHIIDLYQYSDFEETEGLHPCAFLTVWSVRGEFLDVTLHQRSSDYCVAGHVNKVQYVALMMMVARHVGLKPGVFMHVVDNLHIYDRHIEQAKELISRTPSDKQPKLILKEGKTNFYDFTIDDFEMVDYEPVKPQLKFELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I0L5</accession>
    <name>A0A174I0L5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein ERS852471_02299</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266699.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78830">
        <property type="protein sequence ID" value="CUO78830"/>
        <property type="gene ID" value="ERS852471_02299"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="114" mass="12209" checksum="5FC1CBF8887E39D6" modified="2016-09-07" version="1">MARGGFPGGFGGGNINNLMKQAQKLQKEMAQAQQELEEKEFEASVGGGAVLVKVNGKKEVLSIKIKEEVVDPDDVEMLEDLVLSAVNEALKKAEEETANKMGKLTGGMNIPGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2I5</accession>
    <name>A0A174I2I5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ORF">ERS852471_02379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81482">
        <property type="protein sequence ID" value="CUO81482"/>
        <property type="gene ID" value="ERS852471_02379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO81482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="639" mass="71132" checksum="F6AEE4E4718D5428" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I7H4</accession>
    <name>A0A174I7H4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">gidA_2</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="11" type="synonym">mnmG</name>
        <name evidence="15" type="ORF">ERS852471_02367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266802.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81019">
        <property type="protein sequence ID" value="CUO81019"/>
        <property type="gene ID" value="ERS852471_02367"/>
    </dbReference>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="13">
        <location>
            <begin position="9"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="14">
        <location>
            <begin position="401"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO81019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="629" mass="70481" checksum="F47379AEC3681933" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IB18</accession>
    <name>A0A174IB18_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3887 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266898.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83641">
        <property type="protein sequence ID" value="CUO83641"/>
        <property type="gene ID" value="ERS852471_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024115" description="DUF3887 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3887" evidence="2">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO83641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14854" checksum="9A71AB4D8C51F9F9" modified="2016-09-07" version="1">MKKLIKVMSLVLCLSLLISCGTEKLSDKYNEEEIKVVSEQIINNLNHNNYEAVYDMSTDALKETISEGTLESIWTGISEHVGAFKKILNYEVREKDGNPVTAVKTEYLEKNVRFIFVFTEDLKLDAMDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBM9</accession>
    <name>A0A174IBM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase domain-containing protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhhX_1</name>
        <name evidence="2" type="ORF">ERS852471_02391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266848.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82475">
        <property type="protein sequence ID" value="CUO82475"/>
        <property type="gene ID" value="ERS852471_02391"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="36741" checksum="89A64043E43C938F" modified="2016-09-07" version="1">MKLGIVGAGTIVPDFLNAAKEIQDIEVVSISGQESDLKIMKKLAEENTINNIYTNYSDMLKDDIEIVYVAVPNSLHYKFAMEALEAGKNVILEKPFVSSYKEAKELIGFANEKKLFIFEAISNQYLPNYLNIKDTLKVLGDIKIVQLNYSQYSRRYDLFKEGKVLPVFDPKKSGGALMDLNVYNIHFILGLFGKPDKIQYIANVERNIDTSGILTLEYPTFKCVSIGAKDCKAPVTINIQGDKGFIHSDEPANVFNNFIKGSNLGEIKHYNLNSNKNRLFYEIKEFARVIKEKDYEVVAEYNNHTLNVIEILDEARKQVGIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ICM3</accession>
    <name>A0A174ICM3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3737)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266856.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82699">
        <property type="protein sequence ID" value="CUO82699"/>
        <property type="gene ID" value="ERS852471_02397"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1083354at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022208">
        <property type="entry name" value="DUF3737"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12541">
        <property type="entry name" value="DUF3737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO82699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="286" mass="32597" checksum="A57FE49CC7495CC9" modified="2016-09-07" version="1">MKLINEELLTGERALFKSRNLDIVNSNFFDGESPLKESSDINIKSCVFEWKYPLWYCQNINVENTTFLETARSGIWYTDNINIKDSTIDAPKTFRKSRNITLENVTMPNALETLWNCNNIEINKVSAKGDYFGINSKNIDIRDLNLSGNYAFDGGKNIKVYDSKIISKDAFWNCENVTVYNSTIIGEYLGWNSKNLTFINCFIKSEQGLCYVENLVIKNSKFIKTDLAFEYSTIDVESSTSIESVKNPIKGKIKAKSIDEVIMDDIDIDELNTKIFIEEGYGVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGK8</accession>
    <name>A0A174IGK8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84498">
        <property type="protein sequence ID" value="CUO84498"/>
        <property type="gene ID" value="ERS852471_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO84498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="87" mass="10245" checksum="428098874EB22490" modified="2016-09-07" version="1">MVKGLAKTIQMIAWFDENGKINPIKFKYEEENEGTKVICINNVLNRSFEKLAGNLMWKFTCTSIVDDTEYIYNIKYDLINCRWLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IJN8</accession>
    <name>A0A174IJN8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpl</name>
        <name evidence="2" type="ORF">ERS852471_02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266979.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85727">
        <property type="protein sequence ID" value="CUO85727"/>
        <property type="gene ID" value="ERS852471_02465"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO85727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="301" mass="34220" checksum="32CE84ACB55D3609" modified="2016-09-07" version="1">MIKVVGVRFKKAGKIYYFDPTDLKIEKGNYVVVETARGIEFGECVIGIKEVREEDIVAPLKSVIRIASQEDIDKHFDNKAKEEAAFNICFNKIQEHKLTMKLIDVEYTFDNNKVIFYFTADGRVDFRELVKDLATIFKTRIELRQIGVRDEAKMLGGLGPCGRPMCCSSFLGDFASVSIKMAKEQNLSLNPTKISGICGRLMCCLNYEQSTYEDIRKRMPQVGSIVKTEEGTGEVISNNTVKETVRVKYKKAGEEIVNDFNIDNIELIEGNYEDSIDDSDIRLEIDSEEDKKFIKALIKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IRS4</accession>
    <name>A0A174IRS4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplO</name>
        <name evidence="10" type="ORF">ERS852471_02512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267050.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87629">
        <property type="protein sequence ID" value="CUO87629"/>
        <property type="gene ID" value="ERS852471_02512"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="146" mass="15590" checksum="6E05ACA25955C1BB" modified="2016-09-07" version="1">MKLHELKPAAGSRKAPKRVGRGTGSGLGRNAGKGEKGQNARSGGGVRPGFEGGQMPLYRRLPKRGFTNIFAKKYVSINVDRLNIFENGTEVTPELLLETRVISKVLDGVKILGNGTIEKSLTVKGCKFSKQAAEKIEAAGGKVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J294</accession>
    <name>A0A174J294_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase class A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267181.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91230">
        <property type="protein sequence ID" value="CUO91230"/>
        <property type="gene ID" value="ERS852471_02586"/>
    </dbReference>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="130"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO91230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="358" mass="41498" checksum="980569188C0EB075" modified="2016-09-07" version="1">MKNVVRNFMILCIFIILGSAAINNRIRTSSDIEIKDVYAYTLDENEEHMSLDSENIDSDIENTDEGLNEEEIIEEEEPEKVIGKENEEIDIEGDLSNPLFNKDIDIIERIDNYLGDDKCRTSFIYYNLVNEETLSFNEDLYMDAASLYKLGLSLVAYNMVDNGEITLDDLVYYSPWQYQGGTGILQYDLSFGALPLRTLIEYSIKYSDNIAATMIYSYIGGWSNFKWMLFEILDIDYGDYDNITSARVELEILRYIYENRNNSNYATLIDYLKNTDFHDRLDKYLPQDIVAHKIGSNEGYTHDIGIVFTDEPYIIIMMTDNVYDGPDKIADISKAMYLYNIDNQKSIETTATHIMMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J894</accession>
    <name>A0A174J894_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267269.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93415">
        <property type="protein sequence ID" value="CUO93415"/>
        <property type="gene ID" value="ERS852471_02637"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1480188at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO93415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="29161" checksum="037B01CDA3C486FD" modified="2016-09-07" version="1">MRKPSIFSRDYERIMRRRKRIFVTSISLIIISVVLTVTFISRYKFTNIESYLTTWIKDKEKSEKEQKEEILNEEKEIDILETYKNINILLNENEFELKLSDNNGEKFIEGVENLEKDKYCIDSLGKKVIILDKNQNIFLADIEGNVINLTLNKYVSPYGEVFEKDEVLSIYNDYIWHSQVKFLDNNKLAYVSNLPYFGYELSQYVNLIDLDTKEHVTIWELKGGNIILKEIIDGGLEAVIDGNIKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JSU4</accession>
    <name>A0A174JSU4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267635.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02843">
        <property type="protein sequence ID" value="CUP02843"/>
        <property type="gene ID" value="ERS852471_02834"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP02843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="30707" checksum="F0B818C3273777EB" modified="2016-09-07" version="1">MRTDKIKDFVLLTIGVLLVAISVVYFFEPNNITAGGITGLAIVINNYLPSIPIGVLMLIMDAILYVVAFLIIGSKFGRKSIYASIVLSTFIYILEKFAPFNITNDLMLATVFGTIISALGMAIVFNANASTGGTDIIAKILNKFMHIDIGKGLLMVDFFVTLLGAITFGINAGLYSLLSVIANGFAIDNVIAGFNVCKEVTIISPKNEEISKFILEDLERGCTFINGVGGFTGKETTLLYTILGRNEFIKLKRFIADVDKNAFITVGEVHEVMGEGFKGIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JT62</accession>
    <name>A0A174JT62_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cvfB</name>
        <name evidence="3" type="ORF">ERS852471_02800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267563.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00828">
        <property type="protein sequence ID" value="CUP00828"/>
        <property type="gene ID" value="ERS852471_02800"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382881at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="S1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="S1" evidence="2">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP00828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="32262" checksum="68405059939BEFAF" modified="2016-09-07" version="1">MLKIGDYNTLRVDREKDFGFYLVDKESGEDVLLPKSLAEGMNVEVGQEREVFIYRDSKDRPIATFKKPLAKVYDVAYLKVVHQGEFGAFIDFGLDRDIFVPLKEQRFKLRTGDKYLFYIYLDKTNRLAATTEVENYIEIADESVGFKVGDEVTAMVYSRTPSGTLNVAIDGKYKGLVLPNEYYEEIFPGTEMKLRVKRIYEDGVIGLTPRKTRLNERDELKEKIVKYMRKNGGFMEFNDKSKPEDIKATFGTSKNYFKMALGGLMKEGRIEQDSEGCRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JY62</accession>
    <name>A0A174JY62_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267645.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03146">
        <property type="protein sequence ID" value="CUP03146"/>
        <property type="gene ID" value="ERS852471_02840"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1279077at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP03146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="23448" checksum="958E17843D424BF1" modified="2016-09-07" version="1">MKKKIIIAVLLCIPFISILLVIVFRGVMLPTNEEIIKSLKDIKCYEANVEYIIKNSRGEEREDTVQYYSRDKGVRVEFGEDIVKVYKNDGIQVIDNISNSDYVIDKSLDVLHPLAFMNRILSFPIKSDSLKQDQEEWGDTVYIQVDLELFLDNEHLNVARLFVDKKNKTPIGIIVYNKDGEDTLRIIFKDFKKVKQIDDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K0D1</accession>
    <name>A0A174K0D1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267685.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04321">
        <property type="protein sequence ID" value="CUP04321"/>
        <property type="gene ID" value="ERS852471_02862"/>
    </dbReference>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP04321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="170" mass="19554" checksum="38C8B08699CF400C" modified="2016-09-07" version="1">MWLINKVKGLYRFGRLNGRLLVNSFRTSSYYLDSATKFVNTNGFISSSPYFIWVDTENFKTNIFRGSKNNWTLINSYLCTIGKPNNPTIKGTYFVGVKGYSFGESRGFRCLYYTQIKGDYLFHSIPYYLDGTIKDDRLGMMLTDGCVRLSTPHAKWIYENIPGGTTIFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K1D4</accession>
    <name>A0A174K1D4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system lactose/cellobiose-specific transporter subunit IIB</fullName>
            <ecNumber evidence="6">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">licB_5</name>
        <name evidence="6" type="ORF">ERS852471_02860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267683.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04236">
        <property type="protein sequence ID" value="CUP04236"/>
        <property type="gene ID" value="ERS852471_02860"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846001at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025749" evidence="4">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP04236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="100" mass="10707" checksum="848323FE3062C9F1" modified="2016-09-07" version="1">MKNILLVCAAGMSTSLLVNKMKDAAKAKGIEVNINALPVSECSSVVDTVDIVLLGPQVRFQKPQVDALVKGRVPVEVIDMRLYGTMNGAAVLDRALELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5J6</accession>
    <name>A0A174K5J6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267815.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07342">
        <property type="protein sequence ID" value="CUP07342"/>
        <property type="gene ID" value="ERS852471_02934"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="5"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP07342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="416" mass="45519" checksum="535DEAC7D0BDFFFC" modified="2016-09-07" version="1">MKNKNFIIIVLGQIISLFGNAIQRFSMSLYLLEFTGSTAAFSRILAISTIPYILCAPIAGRLSDNVNRKKIMVYLDFFCSVLIGGYAFILLRGRDSELIVGTVMFILSICYTLYGPAVTSSIPQIVEEEKLTSANGIINQVSSIVNFVGPILAGLLYGFVGIKLIVIINAVSFLASAVMELFLDIPDVVKVEEVSCDKDDKVISMDFVKKSFVDMKNSFIYLKKEKKIILGIIASYAFCNIFLVPILSIVAPYFINILLGLSSQVYGIVEGLCVLGMILGGFLISVKPKMFSMKKVHYTYFPMIIGVILMATLGFIKINNYALAGLFAFGGMAIMLSLALSNVLTLTFIQKEVRSDMLGRVSAFSTAVATISVAPGQLLFGQVIDMGIHISIILGITAILNIALMLFIKWNVRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXW1</accession>
    <name>A0A174KXW1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hppA1</name>
        <name evidence="9" type="synonym">hppA</name>
        <name evidence="10" type="ORF">ERS852471_03091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268123.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15007">
        <property type="protein sequence ID" value="CUP15007"/>
        <property type="gene ID" value="ERS852471_03091"/>
    </dbReference>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="699" mass="72988" checksum="6607E41A73A6A203" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXY4</accession>
    <name>A0A174KXY4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urease accessory protein UreI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ureI_2</name>
        <name evidence="9" type="ORF">ERS852471_03096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AmiS/UreI family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268127.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15216">
        <property type="protein sequence ID" value="CUP15216"/>
        <property type="gene ID" value="ERS852471_03096"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2025504at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003211">
        <property type="entry name" value="AmiSUreI_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038523">
        <property type="entry name" value="AmiSUreI_transpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02293">
        <property type="entry name" value="AmiS_UreI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="170" mass="19000" checksum="EA26CCD10206CAC3" modified="2016-09-07" version="1">MLGVVLIYVGVVLILNGVGRLSNVDAKSASVFNVFTGMLSFILNIVAVIQGNYFAAGTGLLFGFTYLYIAARGIFNLDGRLYGWYCLFVAINTVPLAFIDGSTLKFIDFTIGNIYWIFIWLLWGLLWLTGFIELVMKKDLGKFVGYLSIFDGIFTAWIPGFLLLINMYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KYX3</accession>
    <name>A0A174KYX3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15058">
        <property type="protein sequence ID" value="CUP15058"/>
        <property type="gene ID" value="ERS852471_03092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP15058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="51" mass="5988" checksum="59EAB6E4763D3A02" modified="2016-09-07" version="1">MKNNNRRDYTKDNYLRNGTKTQNQYAKSSFNTTIEEPELNESGVEAKKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L289</accession>
    <name>A0A174L289_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268240.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18704">
        <property type="protein sequence ID" value="CUP18704"/>
        <property type="gene ID" value="ERS852471_03163"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026766at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="103" mass="12332" checksum="08F909B714F582A7" modified="2016-09-07" version="1">MSKKNIKEENIIKETKYCKIINQGKVGEGEYTYSIEKIYIKELKRDEVRFCVYKATRRGDETYIPRSLDVTELELIELIKESIREKVFSEEFIEMLKQEINKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L2Z2</accession>
    <name>A0A174L2Z2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">ERS852471_03112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268155.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15949">
        <property type="protein sequence ID" value="CUP15949"/>
        <property type="gene ID" value="ERS852471_03112"/>
    </dbReference>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="147"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="540"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP15949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="594" mass="67196" checksum="EE358E2FA5A4489F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LBE0</accession>
    <name>A0A174LBE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="3">2.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lgt_2</name>
        <name evidence="3" type="ORF">ERS852471_03190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268285.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20221">
        <property type="protein sequence ID" value="CUP20221"/>
        <property type="gene ID" value="ERS852471_03190"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="259" mass="30161" checksum="D4F7D5691BB85EA4" modified="2016-09-07" version="1">MNYFSFFNINIPSYSIMILIGLIIGNVFAFFIIKKRNLILDDFILIETYGLAFGMLGAKLLYLFICRKEIDFTRILDWNYIQPYIKGGFVFYGGFIGGLLGIYLIKIIHKIDVLKYLSELIFCIPLVHGFGRIGCYLSGCCYGIPYNGPFNIEYHNIPYTLCDVNLFPIQLVEAISLFLLAMIFFYLILKYRGSIKLILYYFISYSILRFFIEFYRYDSARGGIWILSTSQWISLIILIISIIILIFNRNLCTKVTNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHT2</accession>
    <name>A0A174LHT2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="9">RNAP subunit beta'</shortName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">rpoC</name>
        <name evidence="12" type="ORF">ERS852471_03227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268353.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22276">
        <property type="protein sequence ID" value="CUP22276"/>
        <property type="gene ID" value="ERS852471_03227"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="11">
        <location>
            <begin position="225"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP22276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130999" checksum="7ED8FCD7B90D33C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LQV2</accession>
    <name>A0A174LQV2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_4</name>
        <name evidence="2" type="ORF">ERS852471_03259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268412.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23879">
        <property type="protein sequence ID" value="CUP23879"/>
        <property type="gene ID" value="ERS852471_03259"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="124" mass="13747" checksum="11EAF069C6F3DFFD" modified="2016-09-07" version="1">MDIIISNSSPIALYEQIENQLKSQILNGKLKPGDPLPSIRTLARELKVSIITSKRAYEELEKDGFIQTVVGKGTFVSGANSERLKEAAMAEMESKLEELIISAKSLGLSLEECIEIFKSIYEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LRL0</accession>
    <name>A0A174LRL0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caax amino protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268452.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25611">
        <property type="protein sequence ID" value="CUP25611"/>
        <property type="gene ID" value="ERS852471_03285"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
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        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="306" mass="35110" checksum="41F90B206C96FFFB" modified="2016-09-07" version="1">MKKIKEANIYFLIIMLLQLFLPVYILFRALNINDIRWMLTINHIIIFIVPALIYLLITKQSPKKVLRLNKLHIKDIFIVICLAFVCQPIMTFFSLISQFFFENEIGNFVGEIVNTPYWILLLLIAVLPAITEEITIRGIVLSGYDNKNIYVACIATGLLFGIMHLDPQQFLYATALGFILALVVRITNSIFASAIMHFIINGTSITIQKIVSFLPSNVDSEISLKAISLGEKLILTFQYGCMAILFAYIAYLLIKKLKKDNIKRGTISKEIFYRKNNEENVFNIYFIFIIVIYLLVMVRQVTSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGQ1</accession>
    <name>A0A173XGQ1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpQ</name>
        <name evidence="3" type="ORF">ERS852471_00038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50854">
        <property type="protein sequence ID" value="CUN50854"/>
        <property type="gene ID" value="ERS852471_00038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="45"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN50854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="278" mass="31742" checksum="8A1716E07DB01ECC" modified="2016-09-07" version="1">MGKKKKITIGLISVLVLLVVVVTTAYIYAIQGEKLDDSDFSWITTVPIAHRGLDNGDVPENSMEAFKKAIESGYAIELDVQLTKDKEVIVFHDSNLLRMTGDSRDVKDVEYDEIKSLKLENTEETIPTLKEVLELVDNQVPILIELKDEKEATDLAAKTYEVVENYEGRYLVQSFNPFTLEWFKNNASEVIRCQLSSDFTDDPNNTLEWYEVFVLKNLLLNFKSKPHVIAYDLNSVDNLSVGLLKAKYPILSWTLANEEHMHMGYKKTDNIIFDNILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XR51</accession>
    <name>A0A173XR51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262827.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54043">
        <property type="protein sequence ID" value="CUN54043"/>
        <property type="gene ID" value="ERS852471_00098"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1725002at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="231" mass="26051" checksum="D8F6BBC58102DF8B" modified="2016-09-07" version="1">MKNDNKRKEIIPPFKRPIFLMIITFVGGYMNGYTYITRNEILANMHTANMSKLGINIALGNYIEALHYFIPIIACILGAAFSELVKTIIIKTKFKGEWRILALLLEATFLFFIGLIPSTFPDIIVTNLVSFLMGYQLCLFRDCLGIPFNTTICTGNIRNVGQLLFQALDEKSIKTLEKLIYFTALTFSFAIGAIPGTLISLVLNTKAVWICSGILFIQAIWINNSKYNKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XU99</accession>
    <name>A0A173XU99_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase-2C</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prpC</name>
        <name evidence="2" type="ORF">ERS852471_00116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262859.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54840">
        <property type="protein sequence ID" value="CUN54840"/>
        <property type="gene ID" value="ERS852471_00116"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="259"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="546" mass="62410" checksum="5BDDD60C84A9C674" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWE3</accession>
    <name>A0A173XWE3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminotransferase-cyclodeaminase</fullName>
            <ecNumber evidence="2">3.5.4.9</ecNumber>
            <ecNumber evidence="2">4.3.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fchA_1</name>
        <name evidence="2" type="ORF">ERS852471_00138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EC" id="4.3.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262903.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55949">
        <property type="protein sequence ID" value="CUN55949"/>
        <property type="gene ID" value="ERS852471_00138"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1965647at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030412">
        <property type="term" value="F:formimidoyltetrahydrofolate cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN55949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="23982" checksum="A0F56D1D13EA6513" modified="2016-09-07" version="1">MFANRKIEDFLENVSSSEPTPGGGTVAALLAALSSSLVSMVYDITSNKSMFLNLDKSVKSEILLAQDRIGNITRLFLKLMEDDAVAFNKVMKAYKLPKSNVDEISFRNNKIQDSYKEALYIPLQTLRESYKLYDYIYLACLYGNKNAITDVGVAALSLQSAIEGAALNVKINAKYIEDREYVSLIIYECNETIKNGRDKRDDILKKVQMELEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ26</accession>
    <name>A0A173XZ26_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inhibitor of apoptosis-promoting Bax1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262895.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55718">
        <property type="protein sequence ID" value="CUN55718"/>
        <property type="gene ID" value="ERS852471_00134"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2057429at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN55718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24408" checksum="DB1F2C8D3FE31327" modified="2016-09-07" version="1">MVKENYLSILKTFFIALIFLVIGGIIGVKFIPATFRYMLNIAFFVVVLFSAFSKRGGLIRNKASMYTYAFILGILTGSTYVYYFARLGPEIFISCIVGVLLVFAFAYFLALRTSEEKIMKLSPIIWGGILALIILEFINIFFFRFGIFDLLLSTAGILIYSLYAIYIMKSIQSRCRYGRLSEGEVVQLSYSIFISFLNLLLDLLRFMSIISDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2R2</accession>
    <name>A0A173Y2R2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ypfD</name>
        <name evidence="2" type="ORF">ERS852471_00188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58441">
        <property type="protein sequence ID" value="CUN58441"/>
        <property type="gene ID" value="ERS852471_00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="195"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="280"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="352" mass="39941" checksum="A1F21BAE0F094BD5" modified="2016-09-07" version="1">MEDQLQLMDQMDLRFRIGDEVQGEILKIGSSEVFVSLVGYKTDGVIPFNELTYAEDLEETLRNLKQGDSIKAKVIKLRNEDNYVVLSRLEYKKEETLELLEGLFDRKETFKVLVKEAREKGLVANFNGVRIFIPASHIDVRFIKDTSEFVNTEMEVRLIDFSRKNPSKIVASRRVILEEQIEEKESKAWEKFNLGDVVSAEIKRFTNFGAFAEVDGVDGLIHISQISWKLVRSCDEVLKIGQVVNAKIIGLDKENKKLSLSIKELTPEPWTNVEEKYPVGSAVLGKVVRINDFGAFVELEPGLDGLVHISKISHNHINHPSEVLTVGQDVKCIILEVNKDAKKIALSIRDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4Y7</accession>
    <name>A0A173Y4Y7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein containing Zn-finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58989">
        <property type="protein sequence ID" value="CUN58989"/>
        <property type="gene ID" value="ERS852471_00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="14305" checksum="6B163AE6623E58C0" modified="2016-09-07" version="1">MEGDFMKYTNDDLCDIFENKICDNCGKCLEIDGIDIRAINIEDIAKDVEENKYLEEELKLALEALKEEETIEVQDTLNYLDDEEYIDAFDNITYLDEIGLDDDLSLDDVTEEVYPGVLKFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y5D6</accession>
    <name>A0A173Y5D6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rny</name>
        <name evidence="8" type="ORF">ERS852471_00205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263025.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59352">
        <property type="protein sequence ID" value="CUN59352"/>
        <property type="gene ID" value="ERS852471_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="329"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN59352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="513" mass="57811" checksum="9E3B8D9D56FD4725" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8C7</accession>
    <name>A0A173Y8C7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphocarrier protein HPr</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ptsH</name>
        <name evidence="7" type="ORF">ERS852471_00203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118696.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59245">
        <property type="protein sequence ID" value="CUN59245"/>
        <property type="gene ID" value="ERS852471_00203"/>
    </dbReference>
    <dbReference type="OrthoDB" id="404807at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN59245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="86" mass="8969" checksum="3236E97C8A27BDAE" modified="2016-09-07" version="1">MVSKEVVVNNGTGLHARPATLLVKKASSFKSDVSIEFNGKKANVKSLIGVLSLGVTKGATITVSANGDDETLAAEEIVKLIETLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWI5</accession>
    <name>A0A173YWI5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smc</name>
        <name evidence="5" type="ORF">ERS852471_00338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263287.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68562">
        <property type="protein sequence ID" value="CUN68562"/>
        <property type="gene ID" value="ERS852471_00338"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="525"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="677"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="768"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="845"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN68562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1185" mass="135554" checksum="18F15EB346ADD4D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYD7</accession>
    <name>A0A173YYD7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Radical SAM domain-containing protein</fullName>
            <ecNumber evidence="9">1.3.99.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemZ_1</name>
        <name evidence="9" type="ORF">ERS852471_00336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.99.22" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263285.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68463">
        <property type="protein sequence ID" value="CUN68463"/>
        <property type="gene ID" value="ERS852471_00336"/>
    </dbReference>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN68463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="39572" checksum="DA0DEE5053476886" modified="2016-09-07" version="1">MSKNYYIIPVFISHQGCPHQCVFCNQDRIARVVEDEVTESDVRKTIDDYLETIDAKGATLEVSFFGGTFTAIPVQKQKELLSVALEYKNRGLIHNIRLSTRPDAINRYILDYLKEYKVDIIELGVQSLDDEVLIKAGRGHTAEQVKEASILIKEYNFTLGHQIMPGLPGDTFEKDIYTTKASISMKPDICRIYPALIIKDTPMEKMYERGEYIPYSLKEAVDISTEMLKLYKEAKIKVIRIGLQPTESITWGQDIIDGPFHPAFRELVEGNLICSSLKEKAPCDKDIIIEINPKDVSKLYTNKKEYFKEFTNNRSGKVFVKVENKVKRNRIRLTVIEKKEEFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z302</accession>
    <name>A0A173Z302_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263338.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70133">
        <property type="protein sequence ID" value="CUN70133"/>
        <property type="gene ID" value="ERS852471_00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN70133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="29791" checksum="E1A1BE6D15FDCC3E" modified="2016-09-07" version="1">MNYSDLYNLIGVKAEINRLERQVSLGWEKEFRTLKWLGLEDGMKILDLGGGPGFFSKLLLENLPNCKVTLLEPDSDFMKFAKENLSEYEGRVEFKEESIYNNSLDGEKYDFVVSRFVFQHLDDPIAASKEIYRVLKYGGIVSVIDSDRGVWGISEPDILKNERNILGRLEKKARWNREVGRKLLRILKLGGFNGLDFEAVAIHSDIVGVGSIAGEMNITNEDIKNLSRVNPKLAHLLKQSKDMISSKNTIVILINLIAKGVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCI8</accession>
    <name>A0A173ZCI8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="9">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnfC_1</name>
        <name evidence="9" type="synonym">rnfC</name>
        <name evidence="11" type="ORF">ERS852471_00420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72865">
        <property type="protein sequence ID" value="CUN72865"/>
        <property type="gene ID" value="ERS852471_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN72865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="441" mass="47452" checksum="67099F0A86866F7A" modified="2016-09-07" version="1">MILVGRIKSTKSLRGIFVKHLKNTAEEKTVSMPVPSTVTIPMSMHIGAPCEPLVKMGDLVKVGQKIGESNAPFSAPIHASVSGKVKQVTEFRNALGMVSKAVVIESDGEQAISEEVKVPVVNSREEFIAAVKESGVVGLGGAGFPTHIKLNPKNLDQIDTLVINAAECEPYITSDYRECMESPEDIIEGINVVKKWLNIKNAYIGIESNKPASIKLLGELSEKHEGIDVVELKAQYPQGAEKVIIYSTTGRIVNDGQLPADAGVIVLNVTTVSFIAKYLKTGMPLVSKRLTVDGTGANKGMNVIVPLGTPIKDVFEFCGGLKADCKKILMGGPMMGIAVPDLEQPIVKNNNAIIALNEKDATPAEETDCIRCGKCVYACPLNLMPAALEKAYDARNAESLVAHDVNLCMNCGCCSYVCPAKRNLAQKNQLAKMFVRQAMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGQ7</accession>
    <name>A0A173ZGQ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynR_1</name>
        <name evidence="3" type="ORF">ERS852471_00466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75307">
        <property type="protein sequence ID" value="CUN75307"/>
        <property type="gene ID" value="ERS852471_00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN75307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="33196" checksum="6DE70E2069265CBC" modified="2016-09-07" version="1">MMELRVLRYFLTVASEDSITNAANILHITQPTLSRQLMQLEEELGVQLFVRGKKAITLTEAGMLLRSRAEEIVDLENRTEKEFLNQKNFLSGEIFIGAGETSGMKELARIIKSFNKEYPQVKYDLHSGNADDIKEKIDKGLIDIGLLTEPVDIGKHEFVRLKEKDNWGVAMRKDDPLSNKEYITPRDLKNKSIVCSKRISIQNELANWFGNDFESGNIIATFNLINNAIAIVESNIGYAICLESLVSDRSNICFKSFYPRLETGSVLVWKKNQIFSTATKMFIEEIKKEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZU11</accession>
    <name>A0A173ZU11_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79714">
        <property type="protein sequence ID" value="CUN79714"/>
        <property type="gene ID" value="ERS852471_00504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="260" mass="29981" checksum="39D7B09468C2F84F" modified="2016-09-07" version="1">MREDLNCEIVKDLLPNYIEGLTSEYTNEAMKRHFETCESCKEAYELLSVNGTEDESLQKKNIYEAKELKYYMKKVRLRNLFLGVIFACLVLGGSYLLYDNLVNICNYNEPSENVEVTELYQLNDNYVYFNLRSKSEYLISAMTFGPGKIDKGYVGTEIHFLRPVIGKKLSKLSEEEKELNLGAGFVIDIENKKLIDVGSFIRANDNITAEEIINYAENKTTEKGNIDIVNSDSKIYYIGRNDDDKLLIWEEGMKLPKYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHD1</accession>
    <name>A0A174AHD1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263769.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86908">
        <property type="protein sequence ID" value="CUN86908"/>
        <property type="gene ID" value="ERS852471_00597"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063425at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025982">
        <property type="entry name" value="SieB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14163">
        <property type="entry name" value="SieB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="20898" checksum="43C74788C2ACA5D5" modified="2016-09-07" version="1">MELIKTIVDKFKIKELVGVVFFTTLLITILPKNIIELMYLGEFKEKYQVYISLGLIIASAYYILSIIVFISEMMVSKLINSKKIAIKYMKNQISPDEMQLIIKTFYDDTNKIFKSSGYISYSDGRKAALENKKIIYLASTISRSGSSFAYNLQPYAREFLNKNLKYGNIKINNDLLEYNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALP9</accession>
    <name>A0A174ALP9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_3</name>
        <name evidence="6" type="ORF">ERS852471_00623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263820.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88590">
        <property type="protein sequence ID" value="CUN88590"/>
        <property type="gene ID" value="ERS852471_00623"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN88590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="51610" checksum="B73485E121B09106" modified="2016-09-07" version="1">MGNKLEHEKIPKLLTSLAIPAICAQVVTLLYNMIDRMYIGRMDNGIMAIAGIGVCVPIISIITAFTGLFGRGGAPLAAIKMGENNTDEADNIISNSFMALIISSVIITILILLFNKEILILFGASQNSLPYALEYMEIYALGTAFVQLTVGMNFYINTQGFAKFGMMTIIIGGILNIILDPIFIFGFNMGTKGAALATVISQFVSFLWVLSFLFGKRTLLRIRRKYLMFNRNIMKQIVTLGSAPFFMSSTEGLLIICFNSQLLKYGGDIAVSSMTIMISMFQFILLPIEGIAQGSQPIISFNYGAKNYDRVRKTIKLAIVVCLIYSFLGTMLMELFPKMFISIFTNDEILLNQAASMLRIYIFGCMIMGANSTFQQTYNSLGEGKRSFFFAFYRKIILLIPLIYVLPMLLPNKLMAVVLAEPISDLLTTVTNGMYFRRFIKVKLPTSSKSNDKAYGELIVDNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALT1</accession>
    <name>A0A174ALT1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bglA</name>
        <name evidence="6" type="ORF">ERS852471_00620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263814.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88408">
        <property type="protein sequence ID" value="CUN88408"/>
        <property type="gene ID" value="ERS852471_00620"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN88408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="478" mass="54667" checksum="0270212CD03BC04F" modified="2016-09-07" version="1">MSLGKDFLWGGALAAHQFEGGVLNTSKGLSVADVMTAGAHGVPRVITDGVVEGNYYPNHVGIDFYGRYKEDIALFAELGFKCFRTSIAWTRIFPLGIENEPNEEGLKFYDNVFDELLKYGIEPVITLSHFEMPYHIAKEYGGFMSRETIDLFVKFAKVCFERYKDKVKYWMTFNEINNQMNYKNDIFGWTNSGAHFGNYENPEEAMYICGHHTLVASALAVKVGHEINPEFKIGNMIAMVPIYPFSCRPADMVLAQQAMHDRFFFCDVQVRGHYPAYALKMFERKGFNVEITEDDKKALKEGTVDYIGFSYYMSNTVDSTAHRDTSTITDGSREHSVDNPFIKVSDWGWAIDPEGLRYALNMFYERYELPLFIVENGFGAIDVKEEDGSCHDQYRIDYLKAHIEQMKIAVEEDGVDLMGYTPWGCIDCVSFTTGEMKKRYGFIYVDRDNEGKGTLERSKKDSFDWFKKVIASNGDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B388</accession>
    <name>A0A174B388_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dockerin type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94206">
        <property type="protein sequence ID" value="CUN94206"/>
        <property type="gene ID" value="ERS852471_00687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="169" mass="16892" checksum="0B502D0B7104C569" modified="2016-09-07" version="1">MSGGTVIVNGPENSGNGALDYDTTFNITGGTFIAAGSSGMAQSPSSSSTQASINIFTNGIANTLVNVTDEPGNEIITFAPSKTFSSIIISTPELQTGNTYTVSTGGNYSLEDIDGLYENGNYSGGSKLTNFTLSSSVMSVTSSGASEGGSMNGGMPGGGGMGGNRTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3A0</accession>
    <name>A0A174B3A0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitric oxide dioxygenase</fullName>
            <ecNumber evidence="5">1.14.12.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hmp</name>
        <name evidence="5" type="ORF">ERS852471_00695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.12.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263964.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94689">
        <property type="protein sequence ID" value="CUN94689"/>
        <property type="gene ID" value="ERS852471_00695"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN94689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="27998" checksum="CEFEAD9F7164DDAF" modified="2016-09-07" version="1">MINGSWNGFRELILVDKVEVCPEIISFYFKSKDGGKLVKHKAGQFLPFKIKTNDPKYKDIIRTYSLSMFPNDELYRISVKKIDGGLISTYLHENLKVGDSIEAMVPTGLFTISNSSKNTPLVLISAGIGITPLLSMLYEESSARNNIHFIQAVQNSTIHPFKDDIASIAKVRGIKNTIFYSKPLENDKLGIDYDYSGYVSKDYLENNVDLNSDFYFCGPPPFMKALENSLLKLGVPTTRIHYELFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BND3</accession>
    <name>A0A174BND3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine 6-phosphate deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagA_1</name>
        <name evidence="9" type="ORF">ERS852471_00831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264220.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02264">
        <property type="protein sequence ID" value="CUO02264"/>
        <property type="gene ID" value="ERS852471_00831"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="46"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="305"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO02264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="379" mass="41826" checksum="79843E6D95835B62" modified="2016-09-07" version="1">MLIQSKKVWIADQFIPAQIEIDYNKIINIYNYNEKSGALDYGDRRIVPGFIDVHCHGAYGFDTNDANEQGLRNWTKGIVSEGVTSILPTTITQSNEVLTKAVANVAKVVEEGYDGAEILGIHFEGPYLDMEYKGAQPKQFITKPTVREFQAYQRAAKGLIKYVTLATETDEDYELTEYLFKNGIVASIGHSAATYEEAVLAFAHGARSQTHVYNGMTPFNHRKNGLVGAAYRIKGMYGEVICDGNHSSLAALYNFFNAKGPDYGIMVTDALMAKGYEPGTKFIFGGNEIEIYEDGSAHLVDTKGLAGSTLRMNEGLRILVEEAMVPFNYAINACTVNPARCLGIDNRKGRIGVGYDSDLVVLNHDYSVHQTYCLGKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPG3</accession>
    <name>A0A174BPG3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264240.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03001">
        <property type="protein sequence ID" value="CUO03001"/>
        <property type="gene ID" value="ERS852471_00845"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="31388" checksum="38451586840FCD8B" modified="2016-09-07" version="1">MNKLKEIRTYLPFARNTFQKLISYKANVIIFMFGDLLMLAVTYYLWKAIYGSSSEAVINGFTLNQMIIYVFITFLTSLMTSVDISQDISREVLDGSIAINLVRPINYEKRMFFQGLGNVFYNFIVIFLITFMLTTFLFYRYFGYINVINIIIYFISIVLGILISFYFSYIFGLFSFKITNMWGMSQIMQAIIQLLSGTLIPIAFFPSWAQAIVKLFPFSSVIYTPTMIYLGKLSNTEIIVSLGIQVFWIVLLMIIAKSMWKSMIKNLTVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0E7</accession>
    <name>A0A174C0E7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Discoidin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264348.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06842">
        <property type="protein sequence ID" value="CUO06842"/>
        <property type="gene ID" value="ERS852471_00892"/>
    </dbReference>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018804" evidence="1">
        <location>
            <begin position="28"/>
            <end position="2283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="3">
        <location>
            <begin position="742"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1536"/>
            <end position="1634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO06842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="2283" mass="255310" checksum="96897D84F03D31C2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C1B5</accession>
    <name>A0A174C1B5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosylasparaginase</fullName>
            <ecNumber evidence="4">3.5.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264364.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07321">
        <property type="protein sequence ID" value="CUO07321"/>
        <property type="gene ID" value="ERS852471_00901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="34863" checksum="270245B627EDB1E1" modified="2016-09-07" version="1">MKYGMIATWRMAVEGITEAAKDLNNGATAGDAIEKAIKMVEDYPLYKSVGYGGLPNENCEVELDAAYMDGNTLSIGAVGGIRDFKNPISIARKLSEERFNCFLVGIGAEEYAHKNGFERVNMLTDRAKQFYEKRRKETIEKGLSPYDGHDTVGMISLDSEGSMVAATSTSGLFMKRRGRVGDSPVSGSGFYCDSEVGGASATGLGEDLMKGCISYEIVRLMKEGMTPQQAADTAVSRLHDELTRRRGKSGDLSVVCMNNKGEFGAATNIAGFSFSVVRDGEEPQVYVCNKQENGVTTYEPASQEWLDAYIKRINSPVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C974</accession>
    <name>A0A174C974_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bglK_2</name>
        <name evidence="1" type="ORF">ERS852471_00921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08430">
        <property type="protein sequence ID" value="CUO08430"/>
        <property type="gene ID" value="ERS852471_00921"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130699at2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="301" mass="33036" checksum="7CF21F732DEE613A" modified="2016-09-07" version="1">MSNYIAFDIGGSSVKWSIINLNGEFLENGKISIPKTIEEFFKAIADKVNELKDKYQLEGVAISAPGAVDSVSGIIGGMSALPYIHGPNFKVILNEMTSLPIEIENDANCAALGECWRGAAMDANDSAFVVCGTGIGGALIKDKKIHTGIHKHGGEFGYCFVDIDVVNKKYLSWSRAGSTFAVAKAIADRKGINIDEFNGVKAFELYDNGDEIAIEEVNKFFRYMAIGIYNIQYTYDPEVIILGGAICEREGFLEEVNKKIDEVMNNNDDATIRPLVRICKYGNNANKLGALYNFLQKQDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAS0</accession>
    <name>A0A174CAS0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264483.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10532">
        <property type="protein sequence ID" value="CUO10532"/>
        <property type="gene ID" value="ERS852471_00963"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1767402at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="24578" checksum="3A491565EE629BC6" modified="2016-09-07" version="1">MLNFAYLLTLIFIIIFILYLLIINKNKCPKKVKTFFCITFALLFMRYIAVLIGTLIESQTIVYFLRCFILLNYPAIPLVALGTAYIFLRNEGTTFDYNFIFMAILLLLYIGELYLYKVNININNSFGFIITFKNSLTPNLIYLIIIASIAIVALLCVDKPYCNKWGMKLLTISLMITIAEFIIFLGGIKVFPYPFIGDILILLVNYKALRTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJD2</accession>
    <name>A0A174CJD2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase family protein</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ugpQ_1</name>
        <name evidence="2" type="ORF">ERS852471_00986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264521.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11656">
        <property type="protein sequence ID" value="CUO11656"/>
        <property type="gene ID" value="ERS852471_00986"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="241" mass="27740" checksum="2B1AE09F2F67475B" modified="2016-09-07" version="1">MTKNFAHRGFSSKYPENTLLAFEKAIEVGVDGMEFDVQLTKDGEIVIIHDETIDRTSNGSGRVKDFTYEELLQYDFSASFTGQFGYIKIPLLREYFDLVKDTEIISNIELKNSVYDYEDLEEKVYELIVEYGLDKKVIISSFNHESIIKMKKIDSEIKCGFLSDCWMIEPGKYTKAYGIECFHPAGYYLTGEKVKAIHNEGIEVNVWLGKEPMDYKKLIDMEIDVLISNDPDIVGEILKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CLS4</accession>
    <name>A0A174CLS4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aroB</name>
        <name evidence="10" type="ORF">ERS852471_01014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264545.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13169">
        <property type="protein sequence ID" value="CUO13169"/>
        <property type="gene ID" value="ERS852471_01014"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO13169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="349" mass="39514" checksum="B78C8637FF120C0D" modified="2016-09-07" version="1">MDLVVDLGERSYPIIIEDGLLDRVDVEIKKVFNGNKIFILTDNNVNKYYGDIIYSKLEEVGYEVKKHVLPAGEESKSFFTLPEVYNSLLEFNLTRSDLIITLGGGVIGDLGGFVASTYLRGVSFVQIPTSLLAQVDSSVGGKVAVDLEKGKNLVGSFYHPKSVLIDPLVLKTLDKRFLIDGMAEVIKYGCIKDEELFKYLENIPNYIELINNIGSIIHRCCDIKREVVEKDERDTGERMLLNFGHTIGHAIEQYYNYSKYTHGEAVAIGMYNISLISEKYGLTQVGTSTKIRSILEKYDLPYNMDIDIENILETMNLDKKKLGKKLNLIILKEIGKSEIYKTTNEFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1M3</accession>
    <name>A0A174D1M3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grxC_1</name>
        <name evidence="2" type="ORF">ERS852471_01113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264633.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19592">
        <property type="protein sequence ID" value="CUO19592"/>
        <property type="gene ID" value="ERS852471_01113"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8700" checksum="00C4875F9166DAB7" modified="2016-09-07" version="1">MIKIYSTSWCPSCVKAKRFFEMKGWEYEEINVADKHEDREEVMRVSGQRTVPVIDIDGEIIVGFDKKKIEEAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DCD2</accession>
    <name>A0A174DCD2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264701.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23113">
        <property type="protein sequence ID" value="CUO23113"/>
        <property type="gene ID" value="ERS852471_01189"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO23113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="579" mass="66957" checksum="B6662B301478B820" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DDV7</accession>
    <name>A0A174DDV7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264683.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22235">
        <property type="protein sequence ID" value="CUO22235"/>
        <property type="gene ID" value="ERS852471_01169"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="17040" checksum="C039062B72730754" modified="2016-09-07" version="1">MRIIINESEDIEELEIVVNCKRVDENLLKMIATIRAFDRKITGTKDGKLFILDVDHIYYFESVDKKTFIYLHKDVYESSLRLYELEDKFANSDFFRASKSTIINLSKIKVITPVFGGKLEVILENNEKLVVSRQYVPLLKRKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXJ0</accession>
    <name>A0A174DXJ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family protein</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lyc_2</name>
        <name evidence="5" type="ORF">ERS852471_01277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264835.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28570">
        <property type="protein sequence ID" value="CUO28570"/>
        <property type="gene ID" value="ERS852471_01277"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="34790" checksum="8C2A025AC12F75C9" modified="2016-09-07" version="1">MIKGIDISNYQAALNFTTAKNMGFEVCIIKATESINYTNPLLDSQVNSALSNNMKIGFYHFFRNNGITEAQYFVSKIKPYLSKMTVKPAIDIETTYSYSQVLDFISYVENVLGIECMVYCNYSYAKQLSLNNEIAKKTLWLAYYGINNGEYYEAPTNHGFAKFAGQQYSSANYIGAINTDTNLFNENVYIKGKVNVTASTGSSSSSGGTSTNTTYTVVYGDTLSEIAKKYAVSVSELVSLNKIVDQNLIYVGQILRIPTSSSDRVKTSQKIYYTVVSGDTLSGIAAKFGTTVAAIASLNKISNVNLIYVGQVLRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0J1</accession>
    <name>A0A174E0J1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264947.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31311">
        <property type="protein sequence ID" value="CUO31311"/>
        <property type="gene ID" value="ERS852471_01340"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2050283at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="9216" checksum="5C9E37713EADE0BA" modified="2016-09-07" version="1">MKSLNYCLECRRVFQSNERCEFCNSDKIKPLKKGTSVNVIGSKTKGSIFNCKGDIASLIIVTEGKEKVIKEYRIDNLKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E3D1</accession>
    <name>A0A174E3D1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.47" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264911.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30540">
        <property type="protein sequence ID" value="CUO30540"/>
        <property type="gene ID" value="ERS852471_01321"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050118">
        <property type="term" value="F:N-acetyldiaminopimelate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="181"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="382" mass="43315" checksum="5AF75A214DC7867B" modified="2016-09-07" version="1">MFFEKEKFIDEVRLYRRELHRIPEIGFCEVNTSKYIREKLESFGYEVKSVAKTGLIAFRQGEISEESIAFRADIDGLKILEETNVFFQSENVDYMHACGHDGHMSILLGFAHYISTIKSVNKGILFIFQPAEEGPGGAEVIINEGVLDHYNVKHVFGLHLFPGLNEGEIGIKAGPMMAQTAEFDIDIKAESGHGAAPHKANDGIIVAAQLINSFQSIISRNINPIEGAVLTIGTINGGERRNIIAENIRLEGTLRAFDKEVYSKIKSRMSDICKGLETMFNVNINIEFRDMYPAVRNDRKLLRSLIKFLPEERLVDIDPMMLAEDFAYYQEAVPSLFFMLGVKNEELGYTHQLHNSKFNFNEEVLVEGMELYHKICEGLNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4F9</accession>
    <name>A0A174E4F9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264927.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30930">
        <property type="protein sequence ID" value="CUO30930"/>
        <property type="gene ID" value="ERS852471_01329"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2090582at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="17613" checksum="248FB4543226453B" modified="2016-09-07" version="1">MLKVPIFEFIARLIPEAFIFMFAAYTFSKVKIEKKKYLMASFLLGISVFIIRMLPINYGVHTILNIIILTVIATSINKINMVNAIKSTIITTVFLFVLEGISVLILSSIYGEELQNMFQDSKLKIILGLPSLIIFGVIVIGYYTYLSKRNKLSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1V3</accession>
    <name>A0A174F1V3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265324.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42908">
        <property type="protein sequence ID" value="CUO42908"/>
        <property type="gene ID" value="ERS852471_01547"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="386" mass="44691" checksum="CFD96C6FC5951466" modified="2016-09-07" version="1">MNIMFINHENSLGGASKSLLGIIDEFSKKEDINIKVVIPSDGRNELENELINRNIEYFKLKYYWWMVPNREEYRTTIYTIKKCLYYIWNYIQAIKLAKICKKSNIDIIHTNSSVINIGGLISRLTGVKHVWHIREFGEEDHNLRFLYDRDKSLKFICRNSAKVIAISESIYNKYESIFTNGKMEVIYNGVNVKNVIEKREKKKEESINILLAGALKESKGQECAILAIKELVKDNYNVTLSLAGKDENNYENKLKELVSKLHLEKNVKFLGFLNSLDKIREDMDLELVCSKKEAFGRVTVEAMMNMNPVIGADTGATVELIKEGYNGLLYRENDEIDLANKIKVLIDDPILRKKIGERGKKFAEENFTSEINACRIYNLYREIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4U9</accession>
    <name>A0A174F4U9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265392.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44701">
        <property type="protein sequence ID" value="CUO44701"/>
        <property type="gene ID" value="ERS852471_01581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="29958" checksum="6530339C6CC3C787" modified="2016-09-07" version="1">MRKIIKSSISLFIFINIFSVNVFAGDLSYIEEALVNLGVNEDYSENIVEYLENIEISESDFQEIENNVNNIKEVVQNNDEEINFLKYYTVYDNIMEIAEIMNLDLDVDLNDLSISLIDKNNNNILYEGDTNSLMQIYSNYRDSNYTINVAEIFEDINNLDESEIAISNTENDTNINSNRFNNEIEINLDTENDLNISNNEKNNVLDEYIDKFEKYNKELLVNNNDDIIEWKIVLIVFGVALAVFIMFKIISRVKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F639</accession>
    <name>A0A174F639_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45842">
        <property type="protein sequence ID" value="CUO45842"/>
        <property type="gene ID" value="ERS852471_01607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="70" mass="8481" checksum="F4BFB9125B6987FF" modified="2016-09-07" version="1">MRKSCKDKCSDNENVRNSSGFYTYEKVNEIIENNIININTEDLCQSRILENWNLHKKYKILLHKTLEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCS9</accession>
    <name>A0A174FCS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002334816.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47571">
        <property type="protein sequence ID" value="CUO47571"/>
        <property type="gene ID" value="ERS852471_01625"/>
    </dbReference>
    <dbReference type="GeneID" id="60291860"/>
    <dbReference type="GeneID" id="66773964"/>
    <dbReference type="OrthoDB" id="770536at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO47571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="267" mass="29327" checksum="0E341928E3A99EE4" modified="2016-09-07" version="1">MALPGTPGQRISDLCNGNHITQKELAEKIGVSASQLSRIVSGETRTVSSDILIGVAKEFKVSTDYILGLSTVSVRKSYDISELGLSEGAVRGLVTGAVDVQILNRLLEHRNFPKLIDLIRIYFQDTAAKGITARNQLIEMATASLSDLMKEHPEHRAEAKQDLQLLNAQKIGEHEAEIEKIKNVFLAILRDIKKDIDNGEQPGEAVTAAMFQAMRDALAEQKQKPLSIDDVTAMIAGQIGQLTPMDKETVEMFQQFAKKMIEQAGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIE7</accession>
    <name>A0A174FIE7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265505.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48419">
        <property type="protein sequence ID" value="CUO48419"/>
        <property type="gene ID" value="ERS852471_01641"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065603at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO48419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="124" mass="13889" checksum="D05B6D630EDF382E" modified="2016-09-07" version="1">MIKVTILQKGNLSLGFKISGHALSREEIENTIGDAYDLICNSVSVLSQSAVIGMEEVLKLPVKYEINDGYLSLNLSELNDDEIEKGQVLLKTFEKSMESLMMSLEASFGKNKRNKYINLKNEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIY0</accession>
    <name>A0A174FIY0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase bgla</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bglC</name>
        <name evidence="6" type="ORF">ERS852471_01676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265566.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50224">
        <property type="protein sequence ID" value="CUO50224"/>
        <property type="gene ID" value="ERS852471_01676"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO50224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="478" mass="55553" checksum="4E50090265A5BB5A" modified="2016-09-07" version="1">MIHSELDKFKDGFLWGSASAAYQVEGAFNKDGKGLSIWDTFSKLDGTTYKSTNGDIAVDHYNIYKEDVALMKEMGLKAYRFSISWSRIFPDGRGQVNEDGLKFYDNLINELIKNDIKPIITIYHWDLPQKLQDLYGGWESREIIDDFNNYCITLYKRYGDRVKYWITLNEQNVFILLGYKLALHPPMVKDDKRMLNANHIASLANAKAIESFRKYVPNGMIGPSFAFTPNYAYTCKTDDVLARENAEDMNCHWWLDIYCWGTYPTFTLSRYERQGVAPEIEDGDIELLERGKPDFIGINYYRSETVEANEIDGISNFEEINTSGKKGTSKNYGVPGVFKTVKNPHLDSTNWDWEIDPTGLRIGIRRINSRYRLPILITENGLGEFDRLEDGQVNDDYRIDYIRNHIKACQEAITDGAELLGYCTWSFTDLLSWLNGYQKRYGFVYVDRDESNVKDLRRFKKKSFYWYKKVIETNGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FM35</accession>
    <name>A0A174FM35_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265609.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51332">
        <property type="protein sequence ID" value="CUO51332"/>
        <property type="gene ID" value="ERS852471_01702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO51332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="16190" checksum="7C95AFBC07316CA8" modified="2016-09-07" version="1">MKLNIIMRTMSILVAVSIIFIIVLYEPNAKKENEFDEISSSVIEETIEEKSVSSDQEVIQGYTSDILTISLDNIINELTLDERSVVKSILDKLSVIDCAKVNSILNSGSIDSKEEALSYIKKRLIEEDYNRLEGILNQYIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRJ5</accession>
    <name>A0A174FRJ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagA_2</name>
        <name evidence="9" type="ORF">ERS852471_01696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265605.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51140">
        <property type="protein sequence ID" value="CUO51140"/>
        <property type="gene ID" value="ERS852471_01696"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="47"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="380" mass="40924" checksum="BC5B368C3CBF03AD" modified="2016-09-07" version="1">MLIKNCKLIYLDKIEEGSVLIEDGKIKEINPSFENCDNVIDGKGLYLSPGFIDVHIHGAGGVDTMDGTYDVINTIAKTIAKHGTTSFTPTTMTVAKKDIRKAISAIKEAKIKGTDGANVLGAHLEGPFISPKAIGAQNPNFLIEPTIENFNEMVGEDEDAVVSITMAPEVDGAKELASYLTDKGIVCSMGHTKATYDEAMNGIKCGFCHSTHLFNAMTPFTHREPGVVGAIFDSEITTETISDGIHISYPSLRTAYKQKGTDKVLLVTDAMMACGMQDGMYSLGGQDVEVKDGAARLLSGSLAGSVLTLDKAIKNVYNNSSYPLNEVVKMASYNGAKHCKVEDRKGLIKEGYDADLVLFDEDINVKMTIVNGNVVYSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G0H2</accession>
    <name>A0A174G0H2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin HipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265758.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56052">
        <property type="protein sequence ID" value="CUO56052"/>
        <property type="gene ID" value="ERS852471_01779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="139" mass="16429" checksum="6C832F6CD1937F5E" modified="2016-09-07" version="1">MMFKTAKDITDIEEYRIVNEELLERIKIARKIKGLSQMQLAKISGLDRSTINEIERNPNHNIKLDTLRKLMTVLDNEILLDDYCKFILNQQEVIQNLIDKFGKEYLCNILGVHRSTLERWGSGKYQVKRRVFEKIKCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6Q7</accession>
    <name>A0A174G6Q7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YtfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ytfJ</name>
        <name evidence="1" type="ORF">ERS852471_01787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265772.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56570">
        <property type="protein sequence ID" value="CUO56570"/>
        <property type="gene ID" value="ERS852471_01787"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014229">
        <property type="entry name" value="Spore_YtfJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39162">
        <property type="entry name" value="PTHR39162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09579">
        <property type="entry name" value="Spore_YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021377">
        <property type="entry name" value="YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02874">
        <property type="entry name" value="spore_ytfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO56570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="141" mass="15441" checksum="764E170C4CF3AA5E" modified="2016-09-07" version="1">MENKHELENLMRSTMENLRDMIDVNTVIGDTIETADGNYIVPISKVSFGFASGGSEFGTLAKRDDFDKYPFGGGSGAGVSVKPVAFLVIRGDSVKLLPMDYDTTVDRIVDSIPDFLESVKSLFKSNNEPLNNSNNNNLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7H2</accession>
    <name>A0A174G7H2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage III sporulation protein AH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265830.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57941">
        <property type="protein sequence ID" value="CUO57941"/>
        <property type="gene ID" value="ERS852471_01816"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1982036at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024232">
        <property type="entry name" value="SpoIIIAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038503">
        <property type="entry name" value="SpoIIIAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12685">
        <property type="entry name" value="SpoIIIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO57941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="18685" checksum="5808DEA409739663" modified="2016-09-07" version="1">MTKKQFGIIFTLMALIVCVGVLSMKLNESGLTDPTDLGAMLLENDTEEQTMSTQDYFYNLRTQKAQSDAKIKDEMKAITEDASASQEAKDIANNSLIQKAQLQEQESRVEMGIMNKGYEDAICMIDSNKVTVYVKVKETPTTEETALLQQLVEDITTLSDIQIETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7N0</accession>
    <name>A0A174G7N0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin synthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjiA</name>
        <name evidence="2" type="ORF">ERS852471_01793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265784.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56879">
        <property type="protein sequence ID" value="CUO56879"/>
        <property type="gene ID" value="ERS852471_01793"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="314" mass="35721" checksum="16220F70B5879568" modified="2016-09-07" version="1">MKVKVDVFSGFLGAGKTRLIKKLINDKYYREKIAIVENEFGEVSIDGAILRETNTVITEINSGCICCQVSGNFKKAISNIINNYEVDRLIIEPTGVAKLSELKRVFEEKELSEVVDIDKLITVVDGERFYIYLNNFRKFFVDQIKAADVIVISRVQFIDKDKLDKIVADIKTLNSKAIVVDKEWSKVNAQELIPIGEHRKGDNKIFRRAYVKNNKGVSAHIDSADDTFQTFAMSLNRAISEKELISKFNFVANTHSFGEIIRAKGIVKLNDETMKQFDFSLDEFSIEAVNYEGDGIISFIGVDLNKDEIKRFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBP9</accession>
    <name>A0A174GBP9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formiminotransferase-cyclodeaminase</fullName>
            <ecNumber evidence="3">3.5.4.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fchA_2</name>
        <name evidence="3" type="ORF">ERS852471_01861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265914.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59863">
        <property type="protein sequence ID" value="CUO59863"/>
        <property type="gene ID" value="ERS852471_01861"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1965647at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_C" evidence="2">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="210" mass="23782" checksum="D20E428CE8F99E54" modified="2016-09-07" version="1">MDFKQYKIDEFIGDLASDLSSPGGGSVAALVTALASALNSMVYSFTIDKKTFESLNQEEKKKMIELSEESKKLIQESLTYMDKDREAFTNLMDCYKLPKETEEDRDIRGKKILDNTILSMNVPLELAEKAIKFYDNIEFAIKYGNKNLISDGIVAAILLHSSIESAIVNVKVNYFSIKNKESVSFVLDRCKELMNESLERKNKIVESFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GP00</accession>
    <name>A0A174GP00_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycoides cluster lipoprotein, LppA/P72 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266064.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64153">
        <property type="protein sequence ID" value="CUO64153"/>
        <property type="gene ID" value="ERS852471_01946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022701" evidence="2">
        <location>
            <begin position="26"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="190" mass="21929" checksum="699D78480E648B26" modified="2016-09-07" version="1">MKKRILSIILISALSISLFVGCGNNNDNNNVQNSNQEQHEQQPEDYKKDDEISSDDKNVESNVVVEEITEEKIEEKFTEIMDYLYTKDYSNEEQSIEAENYIKENFTPEGAENMINKIISYGEKVSYSDLLITLVKNIENNDARYESMYEIRYNVSVTIGKPSIYSDVIAKVVVDKDGKIFIESINDFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GR46</accession>
    <name>A0A174GR46_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ftsH_2</name>
        <name evidence="7" type="synonym">ftsH</name>
        <name evidence="11" type="ORF">ERS852471_01930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266035.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63486">
        <property type="protein sequence ID" value="CUO63486"/>
        <property type="gene ID" value="ERS852471_01930"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="207"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="683" mass="76266" checksum="7CABF257D80DBF17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTN4</accession>
    <name>A0A174GTN4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pmi</name>
        <name evidence="7" type="ORF">ERS852471_01994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266149.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66052">
        <property type="protein sequence ID" value="CUO66052"/>
        <property type="gene ID" value="ERS852471_01994"/>
    </dbReference>
    <dbReference type="OrthoDB" id="645703at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO66052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="311" mass="35165" checksum="F240458C054546E1" modified="2016-09-07" version="1">MYPIRFENIYFEKIWGGRDFENFRDNLPEGEIGETWDVSCHENGTGVVANGELKGKTFLEIIEEFGHDLVGTKVSTEKFPLLVKLINSKEKLSVQVHPGDEYAKTHENSLGKTESWYVVDAKPGAKLIVGTKNCDKATFAKAIEEGRSEDYLNIIEVKKGDFFLINSGLVHAICEGLVIAEIQQNSDITYRVYDYGRPREIHVEKSLDVIDFDLEAINLSNNEVQEFDGFKKVEFCDSEYFGVEKFDISTEWSDESNKEKFFILTCVEGSGVIEGENFSEKIKKGDSFLIPAALGKYTVKGKVEVLKSYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVJ2</accession>
    <name>A0A174GVJ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66742">
        <property type="protein sequence ID" value="CUO66742"/>
        <property type="gene ID" value="ERS852471_02011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="105" mass="12076" checksum="53851CD0F5773A3E" modified="2016-09-07" version="1">MDNNFLKVYSDKNNVYLGFVLDGLEEQNIRYEVLALELIGELNLAKVPFNMAIELNQNNVELKSSDFKGVVNFKVTISNKKIAKEFGLDVGRYIKKIPLKGDWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYC7</accession>
    <name>A0A174GYC7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266139.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65809">
        <property type="protein sequence ID" value="CUO65809"/>
        <property type="gene ID" value="ERS852471_01988"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="51"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO65809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="36252" checksum="A176DCB37D538F29" modified="2016-09-07" version="1">MIKVRIKVIVLISIVALTAGIIIYNIYNNNQISVVTEEIKIENLPEEFDGFTILQLADLHSKSFGENQEDLINIINEQNFDMIAICGDMQDNDEEGYEIFITLLEGINNKEYVFYTPGNHGPFPFENDIGFTNFLSSDFNGRHRRVYNNEKTLSEAGERLKSLGVKLLNEAYEIKRGDSSLWVSELLYKEQLDVITNNEYDNNAINIAVTHYPMESVFDDENYRQHLSQYELVLAAHYHGGQWRIPGIGALFIPDINKAAYFPSQDRVSGLTEVGGIRQYVTRGLGAGGTYEFMRFRFFNRPEINLITLIKNYDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H461</accession>
    <name>A0A174H461_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted NADH:ubiquinone oxidoreductase, subunit RnfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69031">
        <property type="protein sequence ID" value="CUO69031"/>
        <property type="gene ID" value="ERS852471_02057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023096" evidence="1">
        <location>
            <begin position="37"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="317"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="400" mass="43630" checksum="F1520A4670771FF9" modified="2016-09-07" version="1">MLTIKQLGGRKMKKRLIAALAILTLAFGLTSCTTETKDKGIETTQPVVETFAAEYEMKGTTSAGKPKNDTFIFEGTTEDGIITELNFDIIRNKGTEGEYSKKDIMGYQMNVSDVQIEKVGEDFKLTKLSAAGYDPAFEGGQYMITASADIINDTTKFKDLTFINLATQGELEFDKAIAGYKYVAVEAGIEDLNEDTLVKDIIAKYDLHKDGSFVEGTNRISFAGFNGGRSYGEQIDAIAIHILDSKMTLEDVYEMFKTINQIDQPIEERDAVSGATISFVGDFQRMVYVAMNGELFEGVVTHTITDGNTKVEVVTQGYGGEIETHVTFDSTGKIIEIKVRDANETDGIGAVLTTENSEFINALVAGQDNLEGVEVVSGATKTSEALVKAANFAVEYYKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HC08</accession>
    <name>A0A174HC08_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266338.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70549">
        <property type="protein sequence ID" value="CUO70549"/>
        <property type="gene ID" value="ERS852471_02096"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="370" mass="42207" checksum="35636D17BFACAC04" modified="2016-09-07" version="1">MKKQKYLKNFLKAIGILFLAIIVIVGLYVAYMSIQYYRIDDNVVVEDENPSDIILTAKEKHSVITYNIGFGAYNHQFSFFMDSGEMKDGTQVVGSDSKAESKEVVIENTNNSIDFVDNLDADFYLFQEVDTKATRSYNVNQYEMLKRLGSEYSLSFANNFHSAFLMYPFTEPHGSVNSGLTTMSKYRINESIRKQYPVSTDFITKFTDLDRCFLLSRVPVDNGKELVLINTHMSAYDEGGAIRKEQLKVLNEVLEAEYEKGNYVIVGGDFNHDIADTKELFESNQNIPEWVYQLDDNDLEEGFTFVIADNYKEVATCRSTDMPYVEGGNYTVVIDGFIVSDNIKSFRAENLDANFVSSDHNPVALYFILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRS9</accession>
    <name>A0A174HRS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266592.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76276">
        <property type="protein sequence ID" value="CUO76276"/>
        <property type="gene ID" value="ERS852471_02239"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1775694at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="18204" checksum="614A4254AC8CF892" modified="2016-09-07" version="1">MFELKFKFSVIGLIIFLLPMLINIVYFMVAPKKESTVTSNGTSIIEVIEQGSRILFAIFICFFVSYKELNFKNPFLYLSILFLALYYMVWIRYFIGGMNDSLLGKNFLFVPIPLAIFPVLYFIFASLWMNNYIAVGIMIIFGVSHFIISYQNLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HVR3</accession>
    <name>A0A174HVR3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mleN_2</name>
        <name evidence="8" type="ORF">ERS852471_02266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266649.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77238">
        <property type="protein sequence ID" value="CUO77238"/>
        <property type="gene ID" value="ERS852471_02266"/>
    </dbReference>
    <dbReference type="OrthoDB" id="580055at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="33"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="243"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO77238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="436" mass="45712" checksum="C5FFECD3A7369393" modified="2016-09-07" version="1">MQKKGSLSALLPLLVFLIVYVGLSVIAGDMYAVSVIIPFSAAAFTAIFMRGKESLTDKIEIFCKGAGDSNVILMILIFVLAGAFAQVAKDMGAVDSTVNLGLSILPSNLLIAGLFIIACFIALSVGTSMGTIVALVPIAVGVADKTGVVVALAVGAVVSGAMFGDNLSIISDTTIAATRTQGCEMKDKFKMNFKIVLPAAIITAILLAFLTRNAGVTQVESLEYSLVKILPYMAVIVSSLLGLNVILVLLGGTIIAGGIGIYFGAFDIMSLSQSIATGVMGMGELIIISLLISGTISLIKHNGGIDYILNKGLKGFKNKRNAELGIATLVSLVDVCTANNTIAIVTVGPIAKNISDEVGLEPKRVAGIMDMFSCVFQGIIPYGAQLISAAGLAAISPFAIMKYLFYPYLMGVCAVIAIFWHHRNNSKLKIEDKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I3I5</accession>
    <name>A0A174I3I5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp18a</name>
        <name evidence="4" type="ORF">ERS852471_02324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266735.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79625">
        <property type="protein sequence ID" value="CUO79625"/>
        <property type="gene ID" value="ERS852471_02324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="158" mass="18067" checksum="3FB8C4C430137484" modified="2016-09-07" version="1">MFDVFSYVFSNVFDSVINNSQLIDNIVDSVLNSDIVNDMVNTLENMVNLNIDCKEYKRKYLIEADLPGVSKKDIDIDYTNNYISINIKRNQVFSNGKNVAIAVIQGGNDISKDFYVENIDPYNIKAVFKDGKLKVYIPKKDRLKEISPIVEVSDYTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I785</accession>
    <name>A0A174I785_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-rhamnose isomerase</fullName>
            <ecNumber evidence="3">5.3.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rhaA</name>
        <name evidence="4" type="ORF">ERS852471_02406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnopyranose = L-rhamnulose</text>
            <dbReference type="Rhea" id="RHEA:23160"/>
            <dbReference type="ChEBI" id="CHEBI:17897"/>
            <dbReference type="ChEBI" id="CHEBI:62346"/>
            <dbReference type="EC" id="5.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rhamnose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266870.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83042">
        <property type="protein sequence ID" value="CUO83042"/>
        <property type="gene ID" value="ERS852471_02406"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283831at2"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00541">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009308">
        <property type="entry name" value="Rhamnose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06134">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01748">
        <property type="entry name" value="rhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="418" mass="47742" checksum="DF730A7FC89E5055" modified="2016-09-07" version="1">MNVKEKYELAKEQYEKWGIDVDKVLEELNKVKVSIHCWQGDDVKGFEVVQNALSGGIQCNGNYPGAARNAEELRADLDKALSLIPGNHKVNLHAIYLESNGEVVERDQIKPEHFANWVNWAKERGLGLDFNPTIFSHPKASDGLTLSHPDKEIRDFWIRHSIASRKIGEYFGKELGQTCLTNLWIPDGYKDIPADRLGPRARLKDSLEQIYAVETDKNYNLDCVESKVFGIGAESYTVGSNEFYLKFAAENGILSLMDTGHYHPTEVVSDKLSAMLLFDEKVALHVSRPVRWDSDHVVIYDDELKEIAKEIVRNDALDRVIIGLDFFDASINRIAAWTIGTRNMIKALLNAMLTPNEVLRKLQNEGNFTERLALMEEFKTYPIGDVWNYYCEKNNVPVGETWLKEVKEYEEKVLSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IAL8</accession>
    <name>A0A174IAL8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adhR_3</name>
        <name evidence="2" type="ORF">ERS852471_02396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266854.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82667">
        <property type="protein sequence ID" value="CUO82667"/>
        <property type="gene ID" value="ERS852471_02396"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO82667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="135" mass="15904" checksum="6E4B6C61261AAA22" modified="2016-09-07" version="1">MTYTIKEVAEKMGVSVPILRYYDKEGLMPFIEKKENGTRVFKDEDFKGLEIISCMKRSGMPIKDIKRYMDMCMEGDSTLQARLEVFHEREKIVKQQIEELNNIMELIKHKIWYYETAIEAGSESIHKDNKDLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGV4</accession>
    <name>A0A174IGV4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yybR</name>
        <name evidence="2" type="ORF">ERS852471_02449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266944.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84598">
        <property type="protein sequence ID" value="CUO84598"/>
        <property type="gene ID" value="ERS852471_02449"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="108" mass="12368" checksum="EC7CB9F15838740C" modified="2016-09-07" version="1">MKTKKELPLCPVATTVRLIDSKWKLLILRDLLADTRRYSDFQKSIPEISQKVLTQSLKSMVEDGIVIRTAYPEVPPRVEYSLSALGNSLRPVINVMEAWGKNYQANYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IHC8</accession>
    <name>A0A174IHC8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcriptional regulator CtsR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ctsR</name>
        <name evidence="10" type="ORF">ERS852471_02469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the CtsR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266987.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85881">
        <property type="protein sequence ID" value="CUO85881"/>
        <property type="gene ID" value="ERS852471_02469"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2005536at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008463">
        <property type="entry name" value="CtsR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041473">
        <property type="entry name" value="CtsR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041908">
        <property type="entry name" value="CtsR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040465">
        <property type="entry name" value="CtsR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041902">
        <property type="entry name" value="CtsR_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40028">
        <property type="entry name" value="PTHR40028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05848">
        <property type="entry name" value="CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17727">
        <property type="entry name" value="CtsR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010607">
        <property type="entry name" value="Txn_repr_CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CtsR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CtsR_C" evidence="9">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="17029" checksum="2F0BE0CFFBA66017" modified="2016-09-07" version="1">MARISDGIAEFLNNMIEEKTSKEIIIQRNDLADKFNCAPSQINYVLTTRFSHEKGYIIESRRGGGGYIVIKKISNDNNEKIAMMLNEAIGKSITYQGALSLINYLLELNLVTERECDLIKMSVNDRILTSVEDKNKVRADILRGMIAVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IKK1</accession>
    <name>A0A174IKK1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">abgB_2</name>
        <name evidence="2" type="ORF">ERS852471_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266968.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85455">
        <property type="protein sequence ID" value="CUO85455"/>
        <property type="gene ID" value="ERS852471_02460"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO85455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="384" mass="42604" checksum="2B05A1BB91C00F36" modified="2016-09-07" version="1">MNQEMISYLSTCYDELRTLNRDLYANPEDSYKEFFACDSICNLLESHGFDVKRNFLDLETSFYASKGNTYPKICFLCEYDAVPGEGHLTGHNLLTTTSLGASLALSKVIDKIGGTAVVIGCPGEYRGGTKSIMVKQGVFDDIDIVLAAYPDVTTNESGTSAAIVPLKIKFLGNSGLSFLNNDTYTSLDGILLTFNILNSILKGFPKDVEVNSILSQGGFTPLLLPIESEAQFYIRAKEMDMARIAENKLREIAIYVSKLIRVQYSFSLYECPNEELITNRTLNRLFSHNLKENGIIDIGPPRDVRSGLSIGIVSKTVPCIHPYIKVIEDNSIRYGTKEFAETTISPFAFEQSMKASLSLAATAVDLITNNTLLNEIKDEFFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IR79</accession>
    <name>A0A174IR79_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsH</name>
        <name evidence="7" type="ORF">ERS852471_02507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267047.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87400">
        <property type="protein sequence ID" value="CUO87400"/>
        <property type="gene ID" value="ERS852471_02507"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO87400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="132" mass="14654" checksum="FE10240B07735C17" modified="2016-09-07" version="1">MVMTDPIADLLTRIRNANSVRHEVVEVPSSNVKKAVANILLQEGYIKNIEEYNDGVVPMMRIALKYGSNKERVITGIKRISKPGLRVYCKKDEVPRVLNGLGVAVISTSKGIVVDREARKMGLGGEVLCYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IRU3</accession>
    <name>A0A174IRU3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6 7" type="primary">rplM</name>
        <name evidence="7" type="ORF">ERS852471_02527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267075.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88297">
        <property type="protein sequence ID" value="CUO88297"/>
        <property type="gene ID" value="ERS852471_02527"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16242" checksum="63B3CA5580464EED" modified="2016-09-07" version="1">MKSYIAKPQEVERKWYVVDAAGKPLGRVASQVASILRGKNKPTFTPNVDCGDHVIVINAEQVVLTGKKLDQKMMRKYSGYVGGLKETPYREVLAKKPEFAMEEAVRRMLPSGVLGRKMLGKLKVYRGAEHNHEAQKPEVLELKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IU64</accession>
    <name>A0A174IU64_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase CwlD</fullName>
            <ecNumber evidence="3">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">amiC</name>
        <name evidence="3" type="ORF">ERS852471_02530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267078.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88419">
        <property type="protein sequence ID" value="CUO88419"/>
        <property type="gene ID" value="ERS852471_02530"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014234">
        <property type="entry name" value="Spore_CwlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02883">
        <property type="entry name" value="spore_cwlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024582" evidence="1">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="106"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO88419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="234" mass="26213" checksum="6321DA93CCB6506B" modified="2016-09-07" version="1">MKKIIIFVFSIFILLSICTVSAKANVESDDSKVILIDPGHGGIDGGAQSKNGTIEKDINLQIATKLKEKLVSKGYTVYMTRDEDEGLYQKGSTIREKKRDDLKRRTEMKIETNCDIFVSIHQNMFAQSKCYGAQVWYASNDKSSTLANIVQDSLKETIKDNNKRVAKPAGEAYLILRDKFDGASILVECGFLSNPEEEVKLKSEEHQNLIVDGISLGIDRYFNENSNNTNDNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVZ7</accession>
    <name>A0A174IVZ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ykvU</name>
        <name evidence="8" type="ORF">ERS852471_02563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267141.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90236">
        <property type="protein sequence ID" value="CUO90236"/>
        <property type="gene ID" value="ERS852471_02563"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="359"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO90236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="505" mass="55904" checksum="2A88995044F0637A" modified="2016-09-07" version="1">MNKKAENLFVNTIILTITALIMRVIGIIYKVYISNEVGTEGMGLYKLIGTVSSVAITIAVSGISTGVTRIVSEEVSRKNYSNIKAIVFKACAICGGLSIVASVVLFLFSENIALLFLKDERVVISLKIVAISIPFISISSCIKGYFFAVRDIFIPITSQFAEQFIKITVVVGLLSLVMPRGLEYGCAVLVLGTAISDIFSCIYVFISYKLEKKENKNFNVIKEKSGDLLKRLFNIALPVAGSSYIMSAFRSVEMILIPASLVKFGMSTKEAVSVLGGVMGMVFPIISFPAVLLMSLGRVLIPEISRAKAINNNERVNSLITRSIGFTCIIGIMSFFIFSNFYNELSISIYNRDDLGIFFKMISIAIPFMYIDMIVGGILNGLNQQVKSLEYQMLESVLKIVLIYTIVPLKGVNGLIITMLITTVFSFTLSFLRVIKVTNLKINFNNWIIKPLIFSFVSIIIGRVINSVLGEYNLAIGVVTAMVLFVVLMIYLFLLKLFNCIKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IYD3</accession>
    <name>A0A174IYD3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267237.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92404">
        <property type="protein sequence ID" value="CUO92404"/>
        <property type="gene ID" value="ERS852471_02620"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO92404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="134" mass="16102" checksum="AF9E453C9979A6A7" modified="2016-09-07" version="1">MFDYREFDEMLIQEVKSIYKKESWNAYLKDDEKLIRAFSNSLYILGAFDEDKLIGFIRCVGDGEHILMIQDLIVSPEYQQKGIGTYLFRTIMDKYKDVRMFIVLTDIEDVVDNKFYQSFKLRRLDEFNIVGYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J078</accession>
    <name>A0A174J078_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble spore protein C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sas2_1</name>
        <name evidence="4" type="ORF">ERS852471_02630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267257.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93094">
        <property type="protein sequence ID" value="CUO93094"/>
        <property type="gene ID" value="ERS852471_02630"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2064087at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO93094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="6528" checksum="9EC3FDE3395B75DB" modified="2016-09-07" version="1">MAQKLVPEAKNGLAQFKKEVASELGVPLSDYNGDLTAKQNGSVGGEMVKRMVQQYEQGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J915</accession>
    <name>A0A174J915_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267283.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93695">
        <property type="protein sequence ID" value="CUO93695"/>
        <property type="gene ID" value="ERS852471_02645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO93695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="96" mass="9932" checksum="7941D4430F49EEF5" modified="2016-09-07" version="1">MSKKKNRCCCEEVCCCPSNNAGYGGNGCCGSQFAGLNSCVSPIIFLLIACGSGLLRNNRSFLIILLFLLCGGCFGNLFGTNNAGGNGCCCESDCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JAA8</accession>
    <name>A0A174JAA8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">V-type ATP synthase subunit K</fullName>
            <ecNumber evidence="8">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ntpK</name>
        <name evidence="8" type="ORF">ERS852471_02671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267336.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94847">
        <property type="protein sequence ID" value="CUO94847"/>
        <property type="gene ID" value="ERS852471_02671"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1950613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO94847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="162" mass="16841" checksum="E3BB4AAD068D792E" modified="2016-09-07" version="1">MNNMTWIQFLMENSGGIIFAALGIALAVGLSGIGSAKGVGLVGEAATGLVTEEPEKFGKALVLELLPGTQGLYGFVVGFLAFTKLSSGMTLSQGLYIFGACLPIALAGYFSAIAQGRVAAAGIQILAKRPEHNTKGIILSAMVETYALLGFVISFMLVMKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JAT5</accession>
    <name>A0A174JAT5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate uptake ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_2</name>
        <name evidence="7" type="ORF">ERS852471_02658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267309.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94239">
        <property type="protein sequence ID" value="CUO94239"/>
        <property type="gene ID" value="ERS852471_02658"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO94239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="32531" checksum="2604842C0E38470A" modified="2016-09-07" version="1">MLKKNYKGYLYLLPALIILGVFVFYPIINTIIFSFDETKASGFKFGFGSYKYLFTDKRFLTSLFNTVIYAAIVPIISVVISLLLANTLVNLKSEKIRGMFQSIYFLPYVTSLVAIGIVWSWLFNSEYGVINYLLSFIGINPINWLGNPKWAMTALIIFAVWKSLAFNTLILTTGIASINPQYYQAAKLDQASKGTIFREITVKLVSPIIAYTYMISLIAGFKVYTEVYVLFGGRTLDGAVSTVVRYIIDRFYGDQDFPLAFAAAVVLLIVILTVTMVQRVVSRNKIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCS6</accession>
    <name>A0A174JCS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrous oxide-stimulated promoter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267387.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96421">
        <property type="protein sequence ID" value="CUO96421"/>
        <property type="gene ID" value="ERS852471_02700"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1870180at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020483">
        <property type="entry name" value="Uncharacterised_YgbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11756">
        <property type="entry name" value="YgbA_NO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO96421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="99" mass="11772" checksum="7243AB4F2271E18F" modified="2016-09-07" version="1">MGRIDREKKTIKLMIDIYCRKKHGMKDGQLCDECQELLEYAHKRLSYCKFGENKSTCSRCPIHCYKKDMKEKVKKVMKFSGPRLIIYNPVELMKHALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JF38</accession>
    <name>A0A174JF38_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmE</name>
        <name evidence="7" type="ORF">ERS852471_02721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267427.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97271">
        <property type="protein sequence ID" value="CUO97271"/>
        <property type="gene ID" value="ERS852471_02721"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO97271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="28383" checksum="A992D589880867F7" modified="2016-09-07" version="1">MHKFFTAKELINENVGKIIGDDVKHIMKVLRLTSGEEVVLNNCEGTEYLATINSVNKQEVTLNIIKTIEGSNESDIKITLYQGLPKSQKMDLIVQKGTELGVYEFKPVITSRVDVKLKGEFKKLDRLNRISLEAAKQSKRSIVPKVLEPMDFNDVLEEIDTLDLMLVPYENAEGFGIKTLINNLRKDNINLRDIKTVGILVGPEGGFEEEEIVKLKDKGAHIITLGKRILRTETAGFVAASLIQYELSDLGGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JJ40</accession>
    <name>A0A174JJ40_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prophage LambdaBa04, site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xerD_2</name>
        <name evidence="8" type="ORF">ERS852471_02746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267470.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98206">
        <property type="protein sequence ID" value="CUO98206"/>
        <property type="gene ID" value="ERS852471_02746"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="173"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO98206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="421" mass="48169" checksum="7271339A6406B729" modified="2016-09-07" version="1">MKGHIRSRKNSKGEDRFQYIFSQKAADGTRKQITKSGFLSYEEAAKALELAIKEIRSNPVNTNELTFNMIALDYLEGYIKPHKSSNTYTSFVYKYNKYIYPVIGEMKISDITTVTINSLLAAAKNLDPVKPLSSKSVKGIYSLINSIFNKAIKCNIVAFNPCTNADKIRVEKTLPRIFSAEDIALMLSSLNLSFHTDYLIYAIINILLHTGLRRGELLGLTWSDINFTEKTLSVRHQLTYNKGKVLLSNKLKSNSSYRVIPLSTELIDILAYLRKIYHKNRQALGNKYIKNNFNGKNYDFVFVHEDGKVLHPLWPWKQLKKLFLILGLNTDLTLHDFRHTFASNYIKNSNGDICNLTYILGHSSTSFTLDKYCHYITQNRRNTMLVSSKILTESIEAAKKVVTDIVLTISINTSYKKKLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JNA2</accession>
    <name>A0A174JNA2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein/LacI transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yphF</name>
        <name evidence="2" type="ORF">ERS852471_02760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267494.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99138">
        <property type="protein sequence ID" value="CUO99138"/>
        <property type="gene ID" value="ERS852471_02760"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO99138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="325" mass="36921" checksum="D424FFE42FE43D95" modified="2016-09-07" version="1">MRSRKKQYLILFVLILSLFFLIMLSKNFIYGEDNKIYKISVIIRGKSSESWMITKEGIDQAASDMNVDVSFITLSEENNLDEQEQLIKREIDDGIDALIVVPVDYEKMSSSIKSAKEKVPVVLIESTVKNIGNIPYVSCDNYELGKSLAEEIIKAGNYRNNIAIFNSETSYSSVKERCKGFEEVIKESKNNYELWDTSSDVLEGIEYVKKRVKENNIDIVVALEPSTLEILAQAKKELTLENEEFNKIEIYGVGSTNKIIALLEENIINSTIVQNEFNVGYLGVQAAVGLIKGEKISNKNIDFSIISKINMYSDENQRLLFPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JV92</accession>
    <name>A0A174JV92_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA metabolism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP01070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01070">
        <property type="protein sequence ID" value="CUP01070"/>
        <property type="gene ID" value="ERS852471_02806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023875">
        <property type="entry name" value="DNA_metab_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025404">
        <property type="entry name" value="DUF4130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13566">
        <property type="entry name" value="DUF4130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03915">
        <property type="entry name" value="SAM_7_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4130" evidence="1">
        <location>
            <begin position="84"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP01070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="29532" checksum="E761F619CEB8B05D" modified="2016-09-07" version="1">MINEYLYDGTFEGLLTCIFYCYSSKTEVKITKTKNYLPNLISSPIEIVTEIDKFNRVYSSIRDKLSYTTLKTIYYLYLSDVNNIETLIYKYIKLCYNYGNNINLAKNNEIISLVDKYYRKVSLESHRFTGFVRFKKIKAQLYYSTIEPDHNILPIISTHFIERFSDQNFIIHDLKREIALFYNKNNSIITELSKDETKNLLNYSNDEFESLWKTFYNSINIKERENSKLQKMHMPTRYWHNLTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JYR8</accession>
    <name>A0A174JYR8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ftsX</name>
        <name evidence="13" type="ORF">ERS852471_02831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267629.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02748">
        <property type="protein sequence ID" value="CUP02748"/>
        <property type="gene ID" value="ERS852471_02831"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="12">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="11">
        <location>
            <begin position="201"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP02748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="32933" checksum="E7B8F3D87D5EE386" modified="2016-09-07" version="1">MKINTINYFIVDALKSIKRNRTISFAAMLTVLITFFIFGTFTLLALNFNKSIEDIASQVEIRVYLNDDIKMVDQREIEVKLNEQTGVKNVTYESKDEAFLNLQESLAENKGILEGYDLTNNPLPSSFIVTLEDPSYADAVSNAVEKMSGVESIRNQKEQIEKISSFVKVVQVVGIGLFVIFIGVSVFLIMNTIKLTVYSRRREVGIMKFVGATDWFIRWPFVIEGIIIGSIGAGLSSVLLYFAYNGVFNWILSSMFLINLVTPAFVLTTMLGGFILGGVIVGAIGSIAALRKFLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZD4</accession>
    <name>A0A174JZD4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nirC</name>
        <name evidence="7" type="ORF">ERS852471_02886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267730.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05183">
        <property type="protein sequence ID" value="CUP05183"/>
        <property type="gene ID" value="ERS852471_02886"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834167at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP05183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="28597" checksum="F9DDC404EBB2C39F" modified="2016-09-07" version="1">MYSKEIDNLAHSAEVKIGLYKDSKLKYIVAAMMGSFLVSLGIMLIYSIGGIMHHAGNETYKILMGASFGVALSLVFMAGGDLFTSNAMIMTVGALKKKVTWLDAVRIWIAVWIGNLLGGIMGAFLYVQAGLATGKSEYIGEFIVSNVSAKMATPGMQLFLRGLLCNVLVCLATWMCYKLKEETAKILMIFWCLFTFITAGFEHSVANMGFLAMGLMLPHGVDVNIMGYIHNIGWVSLGNFVGGILFVGLPYYFISMKKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K425</accession>
    <name>A0A174K425_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pyrF</name>
        <name evidence="9" type="ORF">ERS852471_02874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267710.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04797">
        <property type="protein sequence ID" value="CUP04797"/>
        <property type="gene ID" value="ERS852471_02874"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181405at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP04797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="32293" checksum="051D3064B78C7A08" modified="2016-09-07" version="1">MDKLIIDKLYERVEERGVVCLGLDTAVEYLPSHVLEGRTLSEALFHFNKEIIDATLDVVACFKVQIAYYEALGIEGLIAYKNTLQYLREKDAIIIADIKRGDIAATASQYAKAHFTGDFEADFITLSPYMGMDSIEPYLPYMKEGIKGVFVLVRTSNPGAEDFENLDIVGGKKLYNAVGDRLTEMGQEVKGKYGYTQIGGVIGCTHVEEGKEIRSRYNDMFFLIPGYGAQGGKAEDVALYLNNGNGGVVNSSRGILLAYKKENREMEFAACAREEAIKMRDEIRRAVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K4W5</accession>
    <name>A0A174K4W5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267746.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05466">
        <property type="protein sequence ID" value="CUP05466"/>
        <property type="gene ID" value="ERS852471_02894"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069900at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="175" mass="19741" checksum="13D1DB29067A0510" modified="2016-09-07" version="1">MDILEIYSALDALGIFLGIVFIFLLGFLLFGVIVYIFTGIAYYKAAEVEDIPNNWLAWIPVGNSYIMLRLAEKNMNFLFVFIASMASTVIRNFFDTGVIFNLISFAISIVSIIISIQCYLVIGKKYEISPAWFIVGCFIIPVMIVPMVMLYKKAKKISRGEATLNSIENDANNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K975</accession>
    <name>A0A174K975_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">chbC_2</name>
        <name evidence="11" type="ORF">ERS852471_02925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06976">
        <property type="protein sequence ID" value="CUP06976"/>
        <property type="gene ID" value="ERS852471_02925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="9"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP06976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="448" mass="48025" checksum="422EA335C157B567" modified="2016-09-07" version="1">MMEKFQAFMEKYFVPLATKLNGQRHVAAVRDAFTLSFPLTMGGSLVILINYVLLSPDGFVASILHLDKLIPNLADYQAIFTPIINGTTSILAIIIAFLTAYELAGNMGGDKLLSGITSLSCYFIMYPTAQEFVNGGSGLSTTYFGAQGLFVSLLVGLVVGELITRLSKNKRLRIAMPEMVPPAVSKSFNLLIPIIMVLGLAGLANFIFLKVTPDGIQALVYNVIQAPLQSLGSSMGTILTFVVVQQLLWVLGIHGPNTLSALRSIIFAEQGLINLEYTVAAGTAWGAPYPVNWGSINDAFGNIGGSGATLGLILAIFLVGRKNKAQYEISKMALAPGLFNINEPIIFGLPIVMNPIYVIPFILAPVVCNIIGYLCVAVFEIIPPVAYSVAWTTPGFLIPFLGSGANNFLSLLIGILCLGVSTLIYMPFVMVSAKAAQKDDDLEVEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KM79</accession>
    <name>A0A174KM79_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted nucleotidyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268051.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13063">
        <property type="protein sequence ID" value="CUP13063"/>
        <property type="gene ID" value="ERS852471_03055"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2008259at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="3">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="118" mass="14159" checksum="D9EF9CA24BFDF42C" modified="2016-09-07" version="1">MKIDVEYCIESNLRSEIIKVKNVCMEILNNPEVYLFGSISKGMYKKNSDIDILILISENKDLKELRNLRHSLEDKIEELKLNRDVDIKLYNKDRYIELTRDISFEQAIYKDLIDIRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KPP3</accession>
    <name>A0A174KPP3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="10" type="ORF">ERS852471_03075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268091.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13962">
        <property type="protein sequence ID" value="CUP13962"/>
        <property type="gene ID" value="ERS852471_03075"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP13962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="96" mass="11320" checksum="8F40228C21FAD5E6" modified="2016-09-07" version="1">MSKKVNYNYAFVFYDVKEERVNKVFKVCKKYLSHFQKSVFRGEMTPSKLIRLKKDLDRVTDKNEDFICIIKLLNDNVFDEEVFGGKSIVTGEDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTJ4</accession>
    <name>A0A174KTJ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ureG_2</name>
        <name evidence="4" type="synonym">ureG</name>
        <name evidence="6" type="ORF">ERS852471_03099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268133.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15363">
        <property type="protein sequence ID" value="CUP15363"/>
        <property type="gene ID" value="ERS852471_03099"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP15363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="203" mass="22436" checksum="F6332F863AF64071" modified="2016-09-07" version="1">MKPVVIGVGGPVGSGKTLLIERLTRVMSKDYSCAVITNDIYTKEDAKFMVKNSVLSEDRVIGVETGGCPHTAIREDASMNFEALEELKSRFDDLDIIFLESGGDNLAATFSPDLVDFSIYIIDVAQGEKIPRKAGQGMIKSDLFIINKIDLAPYVGANLEIMRKDTLAFRSENSFMFTNLKTDEGIQEVINWIKKNCLLEGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTT6</accession>
    <name>A0A174KTT6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ureE_3</name>
        <name evidence="5" type="synonym">ureE</name>
        <name evidence="7" type="ORF">ERS852471_03101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UreE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268137.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15453">
        <property type="protein sequence ID" value="CUP15453"/>
        <property type="gene ID" value="ERS852471_03101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1663151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00571">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP15453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="17996" checksum="A9E111EAF77C2577" modified="2016-09-07" version="1">MIFNQIKGNIRGIENINNYHIEKIFINSDDTLKRILRVTSDHNNEYGIALDKNEELKDGDILLNDGKNLVVIKVKGEDVLVIKPDNITEMGIIAHSLGNRHLQAQFNDGKMIIQYDSLVEEELKRDKINYSRENLKLEKAFRHVEFGHTHTHAHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZA7</accession>
    <name>A0A174KZA7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268160.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16091">
        <property type="protein sequence ID" value="CUP16091"/>
        <property type="gene ID" value="ERS852471_03115"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="22206" checksum="4C95091FC8A186E6" modified="2016-09-07" version="1">MIINTYPMGEYGANCYFVIDELSKDTLVIDPGANGKSIIREIDRLGCNVKAILLTHAHFDHIGAVEELKEKYKVPLYVNEGEVDNCKKDNTVYAKLPSDYNAISDGDILDFNNINVKCLHTPGHSKGGMCFLVEDNVFTGDTLFQGSIGRTDFISGNYDTLISSIEEKLMVLDKNTKVYPGHGPSSTIIYERMRNPFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L123</accession>
    <name>A0A174L123_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amt_3</name>
        <name evidence="8" type="ORF">ERS852471_03097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268129.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15259">
        <property type="protein sequence ID" value="CUP15259"/>
        <property type="gene ID" value="ERS852471_03097"/>
    </dbReference>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="7">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP15259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="401" mass="43475" checksum="CBC53583E645CA4D" modified="2016-09-07" version="1">MIIHGDVAFIILATALVLIMTPGLAFFYGGLVERKNSLTIMFQIFISIGIVTLLWVFGGFSLVFGDDIGGVIGNPFQYFAFKDITYMINLNYSDNIPFLMFFMYQLMFAIITAPLMTGAYANRLTVSGWIKILIIWMILVYFPVAHWVWGGGFLSKLGFVDFAGGAVIHITSGFGCLGGIYVLGERKYKNEHGPFNLGLVAIGAALLLFGWFGFNAGGTLAAAETAAIVFTNTAIAGATGMIVWAILYAMHSKRASFLEIIIGAVAGLATITPASGYVTPLSSVLIGAIAAVVCFFCVEFERKKWDDALDVWGVHGMGGFIGTLLVGVLADPRVNGVSAGLNQFLIQLLGCGIIIVYSVLMTFIIFKVVDKIKSIKVSDEIQLKGLDQAFFKENYETKPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L4X2</accession>
    <name>A0A174L4X2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005210118.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16845">
        <property type="protein sequence ID" value="CUP16845"/>
        <property type="gene ID" value="ERS852471_03127"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1944669at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP16845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="16170" checksum="14C97836FC695224" modified="2016-09-07" version="1">MNELIKILRDYDNDDIIKDFLLDKELEFYNNDMKDIIISLGFYIPNYNILTSLLEIHDSVDPTETEMFANGPITNVINIYHTNISYLYLVRREQFGLRDEDAIITELVFSNNTKELMNKLKIDLCNRNIVRESKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6W6</accession>
    <name>A0A174L6W6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268291.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20354">
        <property type="protein sequence ID" value="CUP20354"/>
        <property type="gene ID" value="ERS852471_03193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP20354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="221" mass="25643" checksum="10420729A5592C10" modified="2016-09-07" version="1">MKKSNITSNLDMNNQFTSSKKSPKVNSHYKKEINLVETLKKAKEKDQGSILTLINKYYPLVDKYSNIYKLKNYEKSDLNQEGNIAILNAINKFDLSKNLNAFDGYTINSIRNKFGTLARIHIKRNTESSLNILGNDEESVEIIDLIEDPINIEENYIKSDEFSRIHSALNTLSKEELTLIDAIYLTKSHSLLKYCKENNLTYHITRRKLKKSLEKLKTYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LB60</accession>
    <name>A0A174LB60_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">capC</name>
        <name evidence="4" type="ORF">ERS852471_03189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268283.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20151">
        <property type="protein sequence ID" value="CUP20151"/>
        <property type="gene ID" value="ERS852471_03189"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666267at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP20151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="28800" checksum="B260FE6587524972" modified="2016-09-07" version="1">MIDIHSHIIPGIDDGAKNEEMALEMLRIAERCGTKKIVATPHFMRGRFDYEYSEVTGEVDKLRKLAKDNNINIEIYQGQEVYYSDRIIKYYDAGIIGTINGTKYMLIELPMLEFNLDEVIDNLYELQLKGITPIIAHPERYRPFIKKPSLINKLINDGCLFQLNAGSVTGGFGKDVKKTAEIYLMNRVYNFVGSDGHRDSKRDTDLTKFLNIVEKEDISLFKESSEAMLNNEEVEFVGNTIKERKKILGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LBW2</accession>
    <name>A0A174LBW2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18960">
        <property type="protein sequence ID" value="CUP18960"/>
        <property type="gene ID" value="ERS852471_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="48" mass="5910" checksum="79DEB16C0A1C5AD6" modified="2016-09-07" version="1">MSLNNAVRNNNLQNSIYGEIIEEDITRREQEEIMASEWFINWMKDYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LFW0</accession>
    <name>A0A174LFW0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-galactosyl-beta-1-&gt;4-L-rhamnose phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.211</ecNumber>
            <ecNumber evidence="4">2.4.1.247</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.211" evidence="4"/>
    <dbReference type="EC" id="2.4.1.247" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP23092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23092">
        <property type="protein sequence ID" value="CUP23092"/>
        <property type="gene ID" value="ERS852471_03244"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205469at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050500">
        <property type="term" value="F:1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035080">
        <property type="entry name" value="Lact_bio_phlase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012711">
        <property type="entry name" value="Lacto-N-biose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035356">
        <property type="entry name" value="LBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09508">
        <property type="entry name" value="Lact_bio_phlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17386">
        <property type="entry name" value="LBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02336">
        <property type="entry name" value="TIGR02336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lact_bio_phlase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_M" evidence="2">
        <location>
            <begin position="439"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_C" evidence="3">
        <location>
            <begin position="664"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP23092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="719" mass="82433" checksum="43F5E87B7FADA652" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJL0</accession>
    <name>A0A174LJL0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AraJ</name>
        <name evidence="2" type="ORF">ERS852471_03267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268426.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24534">
        <property type="protein sequence ID" value="CUP24534"/>
        <property type="gene ID" value="ERS852471_03267"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902621at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP24534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="28159" checksum="8092B2AF0755A950" modified="2016-09-07" version="1">MLNIIYCELLKLKHSKMVLISILGVMSTPFMMFIESLQTHFEHPERVFTLANVYDNSLLYMMLLTNMMIYVVITAYLFSREYTENTLKTILLIPISRTKLLLSKFCTLLLWIAMLTFVTWAGILILSGIYHAVFGMNGYNLVIAIEWLLKFLLGSMLMFLTVSPFAYIAQKTKGFVAPVIASAVIVMGSAALTNQDFGALYPWTATFFLIEGKIQSTGYPIPLAIAIIVFVSIAGFLLIFSHFKKEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LKZ1</accession>
    <name>A0A174LKZ1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glgA_2</name>
        <name evidence="7" type="synonym">glgA</name>
        <name evidence="10" type="ORF">ERS852471_03273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000037">
        <property type="protein sequence ID" value="CUP24984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268432.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24984">
        <property type="protein sequence ID" value="CUP24984"/>
        <property type="gene ID" value="ERS852471_03273"/>
    </dbReference>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="289"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP24984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="478" mass="55125" checksum="9FB4533670B711C0" modified="2016-09-07" version="1">MKVLFVTSEANPFVKTGGLGDVMGALPQSLHNLGVDARVVLPKHKNIKGDYVKKLEFIKWFMVPVGWRNQYCGVFKYEHKSVTYYFIDNEYYFNRDGLYGYGDDAERFAFFDRAVLCFLKEIDWQPDIINCNDWQTGMIPVLHKLEYRKDPFYSNMKTVFSIHNLLFKGTFSPDILPNYFGYDYMPMANGSVELHGGASFMKGALNYSDIITTVSNSYAEEIKTPQYGEGLDGLLREKSFRLKGIVNGIDYEEFNPEEDNLIYRKFNYEDLKGKTENKILLQKELGLPQKENTPMIGLVSRLTNQKGCDLIINIIDRLLQNDIQVVILGTGDYLYEETFKKLQYRYPDKISANIKFDNVLAHKIYAASDMFLMPSLFEPCGLGQLIALRYGTIPIVRETGGLKDTIRPYNQYSKVGNGFGFKNYNANELMSITEYALALYKDKEHWKGIVRQAMESDNSWEKSAQEYKKLYEELLTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LLD3</accession>
    <name>A0A174LLD3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">rplK</name>
        <name evidence="9" type="ORF">ERS852471_03233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4 6">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268363.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22500">
        <property type="protein sequence ID" value="CUP22500"/>
        <property type="gene ID" value="ERS852471_03233"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP22500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="141" mass="14903" checksum="E436EFDF6B2F93C4" modified="2016-09-07" version="1">MAKKVTGMIKLQLPAGKATPAPPVGPALGQHGVNIMGFCKEFNAKTANQAGLIIPVVITVYQDRSFSFILKTPPAAVLIKKELGLESGSGVPNRTKVGKLTKDQVRKIAELKMPDLNAASIESAMSMIEGTARSMGVTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LNH3</accession>
    <name>A0A174LNH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205711.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25663">
        <property type="protein sequence ID" value="CUP25663"/>
        <property type="gene ID" value="ERS852471_03286"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2012991at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP25663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16115" checksum="30204AEE2460F204" modified="2016-09-07" version="1">MQFVIFIILISAIAGVYLYYDQQLAKVKKQLMITSNQLRKCKTQHRSLATIDKPLNIKFINPSSQIGITNTSAKLYLAPTLDSPKLNTLSIKMEVKILDSALVDNLLWFYVNLPIDSDINCRGWISKNDFSTIFPNSNSMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LNQ6</accession>
    <name>A0A174LNQ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9 11">Uracil-DNA glycosylase</fullName>
            <shortName evidence="9">UDG</shortName>
            <ecNumber evidence="4 9 11">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">ung</name>
        <name evidence="13" type="ORF">ERS852471_03289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9 11">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 11">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 9 11"/>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268456.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25743">
        <property type="protein sequence ID" value="CUP25743"/>
        <property type="gene ID" value="ERS852471_03289"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1260295at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="12">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP25743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="225" mass="25788" checksum="B58519737212F5FF" modified="2016-09-07" version="1">MKKILNNDWQDLLEEEFNKDYYLSLRSFLAKEYKENTIYPDKYDIFNALHFTPYKDVKVVILGQDPYHGPNQAHGLSFSVNPNVPIPPSLLNIYKELKSDLGCYIPNNGYLKKWADQGVLLLNTSLTVRASQANSHKNIGWETFTDKIISLVNEKEDPVVFILWGNNAIKKKSLITNKRHLILTSVHPSPLSASRGFFGTKPFSKTNSFLESVNKTPIDWQIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LUP9</accession>
    <name>A0A174LUP9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000041">
        <property type="protein sequence ID" value="CUP26711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26711">
        <property type="protein sequence ID" value="CUP26711"/>
        <property type="gene ID" value="ERS852471_03300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP26711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="52" mass="6155" checksum="8E11E97D5C65E9BB" modified="2016-09-07" version="1">MFRIKINDFGGLYGEKKYLYKIGNFAVHKSDDFHIIFYQNSLKILDINLGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LUT6</accession>
    <name>A0A174LUT6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase, patatin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rssA_2</name>
        <name evidence="4" type="ORF">ERS852471_03316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000044">
        <property type="protein sequence ID" value="CUP27853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268498.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27853">
        <property type="protein sequence ID" value="CUP27853"/>
        <property type="gene ID" value="ERS852471_03316"/>
    </dbReference>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP27853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="34013" checksum="53F5A51200D975DB" modified="2016-09-07" version="1">MKIGLVLAGGGARGAYQIGVWKALIELGIDKYIEVVSGTSIGAVNAMLFQQNAYEMAEEFWCNVKKEQLLPIDEKELLVKGVLYAIGAKNINFIRKYIPKALKAGTLTREGMNEFVDKMDFDAIKNSKIKGYATCTRLPDLKTEYFYINDNSVEDIKKILWATSAVPMIYDSQEINNAEYLDGGVGDNVPIQPVYGEGCNIIIVVHLANDSFIDKSLYPNTSFIEIIPEDIEEYDLKEIMGFDSNVIKQRMFKGHKDAIDKIKPIMDITRLIDKNELEKQKNEQKFVNKLNKMFNKIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XF21</accession>
    <name>A0A173XF21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbpE</name>
        <name evidence="3" type="ORF">ERS852471_00004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN48978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262672.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48978">
        <property type="protein sequence ID" value="CUN48978"/>
        <property type="gene ID" value="ERS852471_00004"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015406" evidence="1">
        <location>
            <begin position="26"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN48978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="424" mass="47982" checksum="9B67671F769C02DB" modified="2016-09-07" version="1">MKKRYVLLVIGLTISSILTLTACSSEKTVTDAQINIIRDGVAEQEEKSDNNVAEESVEERNIEQYKVEQYRFESEPVETEYKDVDKIVEAGYENVEEFLDQEAAIREFQGVALVAVGDEIKFAKAYGYADTNRENTLTTRFAIASNTKQFTAAAIMQLVEQNKVDLDETIDKYFPDYEYGSIITVRELLQMRSGIPDYLNEAEVFMRSEESLSILNDYRNNTYFDKYVEDARWSKELILKDLNLSDLYFQPGGAYDYCNTNYYLLGLIIEQASGLSYEEYINKNLFEPAGIVTSSMKAEESDAKGHGSAESGVIKANPEFTYAAGNIYSNIFDMFRWMRAFHKGNIVSDQSYNQMVTAVDGYGFGLFVNDGIIRHSGVIDGFNSNTEYDILNDITIIVMENSDATTGLLDAKYDTSMIRGLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIZ6</accession>
    <name>A0A173XIZ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262710.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50398">
        <property type="protein sequence ID" value="CUN50398"/>
        <property type="gene ID" value="ERS852471_00030"/>
    </dbReference>
    <dbReference type="OrthoDB" id="92716at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="562"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN50398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="939" mass="109299" checksum="E32C09BAF09B8CA0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNA8</accession>
    <name>A0A173XNA8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262795.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53362">
        <property type="protein sequence ID" value="CUN53362"/>
        <property type="gene ID" value="ERS852471_00082"/>
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    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN53362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="29366" checksum="D68DACA7CD62E2FF" modified="2016-09-07" version="1">MKIGIFYFSATGNTADLAKVMKSTLESKHNIVEIRKFEEGWFKNYNDFDFFIFGSPKHYEYIPLFFLNWIQDNLSECDKPTDAAIFINGAADLNSGFKKMINILKSKNINVKATKTIKMSNNYFLPPFDKSYKEPLISSCETGEEIARKFAIDINNGKMQLEKANFLLENMCKDVSYFFGKKSNKVAKNFSTSIKCNKCGTCVRNCPENNIFIKDGKIVFGDKCITCARCLNICPMNAILYKGKEIKQYKLKMKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSH0</accession>
    <name>A0A173XSH0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">degA</name>
        <name evidence="2" type="ORF">ERS852471_00095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53906">
        <property type="protein sequence ID" value="CUN53906"/>
        <property type="gene ID" value="ERS852471_00095"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="334" mass="37499" checksum="54EBA987DB694A47" modified="2016-09-07" version="1">MIITKKNGVTFSPETIEKVMDAVNKLNYISKTDKSQNIIKATNQVIAVICPNITNPYYSTIVQAVEQVAKQNGIDVIIFNTYRDPKIEKRIIETFYNLNLAGIIFAMMPSNPQFAEQLSSKLPIVVIGDSDYSVHIDTVEVSNYNAGVLIGNHLIELGHKHIAFLSPTLDHINTSRLNRLEGLKATYKKHGNDYSITVKSQNITPDIERDNISIEHAIGYNLCKEVLKDKKVTAFVGLNDMVAYGIADAIIDSGYKIPNDYSICGFDNIFPSHFAPVSLTSIEHCIEDIGHNAFKILLNKINEYTKPQFKNSSIIRVEYEQRLVQRNSTGPARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XUA0</accession>
    <name>A0A173XUA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54496">
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        <property type="gene ID" value="ERS852471_00108"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN54496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="43424" checksum="C3DBB9840BD8861B" modified="2016-09-07" version="1">MEQKKLGFGFMRLPITNKEDQSSIDYKQVNDMVDVFMERGFTYFDTAYMYHNFISESVIKEAVVKRYPRNAFTIATKMPTMFLKKEEDLERIFNEQLDKVGVEYFDYYLLHNLGVSNYEIAKKFDAFKFIKSKKEEGKVKKIGFSFHDTADLLDTILTEHPEVDFVQLQLNYIDWDNESIQSRKCYEVATKHNKPVIVMEPIKGGTLANVPPKAEQLFKEYHNDMSVPSWAIRFAASHKNVMMVLSGMSTMEQLLDNTGYMEKFKPFNEEEYDIINKVVDIINDSIEIPCTACQYCVDGCPKKIDIPKYFALYNAEKQSESKGFSTQGVYYANLTKTYGKASECINCKKCEKSCPQHLNITEYLKNVAMTFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWT7</accession>
    <name>A0A173XWT7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262867.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55055">
        <property type="protein sequence ID" value="CUN55055"/>
        <property type="gene ID" value="ERS852471_00120"/>
    </dbReference>
    <dbReference type="OrthoDB" id="690156at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN55055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="575" mass="66326" checksum="3A311BDA40BFB6AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ50</accession>
    <name>A0A173XZ50_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262908.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56137">
        <property type="protein sequence ID" value="CUN56137"/>
        <property type="gene ID" value="ERS852471_00141"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940131at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010718">
        <property type="entry name" value="DUF1294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06961">
        <property type="entry name" value="DUF1294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="87" mass="10237" checksum="5C77CBB0A0E0331D" modified="2016-09-07" version="1">MIKYFTIYFIIINFVSFILMYIDKRRAIKKEWRISEHTLILISLLGGSIGSLIGMYTFRHKTKHLKFKVGIPIILVIQLLVIANIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0B6</accession>
    <name>A0A173Y0B6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">truB</name>
        <name evidence="8" type="ORF">ERS852471_00161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262942.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57103">
        <property type="protein sequence ID" value="CUN57103"/>
        <property type="gene ID" value="ERS852471_00161"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="7">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN57103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="33056" checksum="6DF771F9355B6741" modified="2016-09-07" version="1">MNGVLNIFKPKGMTSFDVVREVKKVCKIKKVGHTGTLDPEATGVLPVCIGKATKIIDYIMDSEKIYEVTFKLGLKTTTYDLEGEILEERDSSFLKYEEILNAINSFKGEYCQVPPMYSALKQNGVRLYELARKGIEVERPGRNITIYNIEDIKIDNPYISMKVTCSKGTYIRSLCYDIGEKLGVYAAMTELCRVKTSRFLIENSVNINELTKDNLTQNLISIEEALNEFDKIVVNNKFAKLLVNGVNVFDSRVANEKLIANKLYRVYDENNNLLGIGSKNNNGFKIEKLLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3I5</accession>
    <name>A0A173Y3I5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="6">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="6">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="6">IPP transferase</shortName>
            <shortName evidence="6">IPPT</shortName>
            <shortName evidence="6">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">miaA</name>
        <name evidence="10" type="ORF">ERS852471_00193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6 8">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6 9">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263006.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58711">
        <property type="protein sequence ID" value="CUN58711"/>
        <property type="gene ID" value="ERS852471_00193"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN58711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="35905" checksum="8953D38C238EF7F3" modified="2016-09-07" version="1">MKQKLLIIAGPTGVGKTELSIKLAKLLDGEVISADSMQIYKHMDIGSAKVTNEEMNGVKHHMIDVVMPDKSFTVVDYKNMAEKEINDVIRRNKLPIIVGGTGLYINSLTCNMNFSEAESDIEYRKYLEDLAKEKGNEYVHNLLKEIDPISYEKIHANNLKRVIRALEVYKISGKPFSSFNDLDTFYKSKYDIYYYVLTMNRDKLYNRINLRVDKMMDDGLLQECINLKELGYNTSMQSMQGIGYKEVFYYLDKKISLEEAIDMIKQGSRNYAKRQLTWFKKDPRVKFIDKDIYSEDDIINLIVKDLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6W4</accession>
    <name>A0A173Y6W4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263041.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59901">
        <property type="protein sequence ID" value="CUN59901"/>
        <property type="gene ID" value="ERS852471_00215"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2140479at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="39610" checksum="DBCA66956DDCF7B1" modified="2016-09-07" version="1">MVENNKNEEKTICLDENIKEFEVEDEFNQNKTDGVIQNEKLETKGLKLKKSTKDRLNQLQSKFGDAETLISTLLNQYEAIKIENNSKFADRKAEIDKFNYLLDSIRSSYLSSLDMATFIQEKYNEKFQSEIKSRENIIKSLQEENIKIKDDFRNIEEELSIKNNELKDSKDNFTKVNDLINTFENDSKEKSLQIQNLQKHINSLTDIVDQSKEVREKYESLQELVENLQSQISNYKILDNEVLKLNKELEGARSEIDTLKDDLRREREYSNSLNEKMHNLILMNSNESSRLKDQYLEEKKSIEIEKNNIIEDNLKVIATLKDEIYNLKLEILKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCA4</accession>
    <name>A0A173YCA4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lldD_1</name>
        <name evidence="3" type="ORF">ERS852471_00242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61564">
        <property type="protein sequence ID" value="CUN61564"/>
        <property type="gene ID" value="ERS852471_00242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="237" mass="24816" checksum="67284A468EB2E705" modified="2016-09-07" version="1">MTYNNILVSTCAKEGILAFTGDGVNQDVMKAATTAIKNVGGFGIPTVKPWNIDTIEEKMNLVKESGAIAVAMDIDAAGLPFLKNMNPPAGAKSVNELKEIINFAGIPFIVKGVMTVRGALKAKEAGAAAIVVSNHGGRVLDQCPATAEVLAEIVAAVGDSMKVFVDGGIRSGVDVFKALALGADGVLICRTFVTALYGGEEEGIKTYINKLASELEDTMAMCGAYSIKDITREMIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRY6</accession>
    <name>A0A173YRY6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein ERS852471_00305</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118106.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66664">
        <property type="protein sequence ID" value="CUN66664"/>
        <property type="gene ID" value="ERS852471_00305"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786332at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN66664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="89" mass="9758" checksum="B7D567FE45BB1F6C" modified="2016-09-07" version="1">MGIKLINIGFGNIVSANRLVAIVSPESAPIKRIIQEARDRGMLIDATYGRRTRAVCITDSDHVILSAVQPETVAHRLSTKDETVDEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YT52</accession>
    <name>A0A173YT52_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NifB/MoaA family Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263215.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66225">
        <property type="protein sequence ID" value="CUN66225"/>
        <property type="gene ID" value="ERS852471_00297"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504159at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ_6" evidence="2">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Radical_SAM_2" evidence="3">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF512" evidence="1">
        <location>
            <begin position="219"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN66225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="50843" checksum="83D1634397752C6D" modified="2016-09-07" version="1">MRNVVTNVIPYSIAEEVGIEVNDILLSVNGEKITDIIDYRFLTADEELVLEMEKSNGEVWEYEIEKDYGEELGLEFGGGIMDKAKRCSNKCMFCFIDQNPKGMRETLYFKDDDSRLSFLQGNFVTLTNMKDEDIDRIIRYRISPINISVHTTNPELRVKMLGNRFAGQVYDRMKKLADAGIEMHCQIVLIPEVNNKEELKKTINDLYSLYPSVANVAVVPIGVTKFRDGLVKVKTFDKELAREELEMVMKFQEKFMNEIGDPFIRMSDEFYIVSGIDVPEEEFYKGYEQIEDGVGMIRCFREAINYGVQNLRKDISGTFTIATGKLAFNEVMNGAKKIMKANENIKIDVFEIINHFYGESITVTGLLTGKDIISQLKGRIKSEYLIMSSNMFRKGYELAPADYIMLDDVRVEDIEKELGVKVLVADHTGEDLIDIINDVCQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4Z2</accession>
    <name>A0A174A4Z2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine/lysine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speA</name>
        <name evidence="5" type="ORF">ERS852471_00541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263665.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82596">
        <property type="protein sequence ID" value="CUN82596"/>
        <property type="gene ID" value="ERS852471_00541"/>
    </dbReference>
    <dbReference type="OrthoDB" id="485164at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="6"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="403"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN82596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="471" mass="53465" checksum="AE997B5F602229D5" modified="2016-09-07" version="1">MKNRLPLLEEVLKYHKEKNLILSMPGNKSGIGFLRDDIGKEFVNSMGFLDITEVGNLDNFHHPEGVIKEAQELLANLYKVDRAYFLVNGSSSGNLASVFAAFNEGDEVLVERNCHKSIYNALILRKLKPVYIEANIDLDNGILLPCNEKNIKDALIKAKDPRGVILTSPNYYGISYNLEKILRKLRGNGLKIIIDSAHGAHYGVNQRLPESMARLAHYVVLSAHKTLPALTQGAYLLVNDINSNVEFFISAFNTTSPSYLIMSSLDYARYYLENYGDSDYDLLIDLAEVYKNQINSLDKVKILSEEDIEGDYKLDKSRYILTLPIGYSGNKLLDYLLENNIQSEMSFSRGVVLILSPFNTRDDFEKIYHAIMFLDIETLKDEEKNIGYVNLEKIKRLEPFEVHNAKFEEVEINHAVGMVSKDFIVPYPPGIPLVLPGEEITEDVVKAIRWYQGKCISVLGVYYNRIKVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6J1</accession>
    <name>A0A174A6J1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tetD_2</name>
        <name evidence="3" type="ORF">ERS852471_00557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263693.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83793">
        <property type="protein sequence ID" value="CUN83793"/>
        <property type="gene ID" value="ERS852471_00557"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="32951" checksum="4B168440CC0B10D1" modified="2016-09-07" version="1">MEWIESIREAISYIEDNITKDLSIEEIADRVNISPFYFQKGFGMLCGYSLSEYIKRRRLSLAGSDVLSTNEKIIDIAIKYGYDSPDSFTKAFTRFHGVTPSAVRKEGAMVKSFVALRIKFSLEGGYIMDYKIVEKDEFKVIGASKKFKYESAFMEVPSFWNEHISQGKLKDICGMYGINIDEKMSGDEFEYLIAEDYSQEKDGMEGYIVKTIPKFTWAIFPCYGPSPQAIQEANKKIFSEWLPNEREYTIAAGYNIEMYNDPSKYEKGILDKNYYSEIWIPVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AAU3</accession>
    <name>A0A174AAU3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cysK_1</name>
        <name evidence="4" type="ORF">ERS852471_00582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85731">
        <property type="protein sequence ID" value="CUN85731"/>
        <property type="gene ID" value="ERS852471_00582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="12"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN85731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="335" mass="36989" checksum="AB05DE5F71E4872E" modified="2016-09-07" version="1">MNISNKISNLEKLIGNTPLVEISFTYKGKPLKVYSKIEHYNLTGSIKDRIAIYMIKKAYSDKRLKENDIIVEATSGNTGISFAAIGAYLGHEVHIYMPDWLSTERMKLLESYNAKLHLVSKEDGGFLKCVSLAEECSKNCSDIFLPGQFSNVDNTYAHYYSTGPEIYHALKKHGLKADLFIAGVGTGGTVMGIGKYLKERNRNLKIYPLEPSNSPTLSKGKHTSSKHRIQGISDEFIPAILDLSKLNDVISVDDGDSIIMSQMICKKFGLGVGISSGANFIGAIKALELNNFKGNIVTVFADDNKKYLSTDLMNVEPIKEGFISSDVELLDLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGG6</accession>
    <name>A0A174AGG6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_00599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263773.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87009">
        <property type="protein sequence ID" value="CUN87009"/>
        <property type="gene ID" value="ERS852471_00599"/>
    </dbReference>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="486" mass="55286" checksum="FACADECBF8604991" modified="2016-09-07" version="1">MITGELRSKVDKIWETFWTGGITNPLEVIEQFTYLLFIKGLDDKEIVKENDAVLLGIDFDRTFPEDKQQLRWSKFKNFEAGEMYKVVSEEVFPFIKNLHNNADSAYAKYMGDAIFKIPTPLMLSKIVDGIDNIDMEDDKDTKGDLYEYLLSKVATAGTNGQFRTPRHIIDMIVKLMKPTPEDIIVDPAAGSAGFLVSSQAYLRENHPELFLVQGLKEHFNNGMFYGFDMDRTMLRIGAMNMMLHGVDNPNIEYKDSLSEVNTDKDKFTLVLANPPFKGSLDYEAVSADLLKTTKTKKTELLFLALFLRILKTGGRCASIVPDGVLFGSTGGHKSIRKEIVENHKLEAIISMPSGVFKPYAGVSTAIMIFTKTGTGGTDKVWFYDMKADGYSLDDKRNPIEDNDINDIVERFSNLDKEVDRKRTEQSFFVPVEEIRDNGYDLSINKYKEIEYEEVHYDSPQEIMLRIRELEMEITAGIEELAEMIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJG5</accession>
    <name>A0A174AJG5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">emrB</name>
        <name evidence="9" type="ORF">ERS852471_00607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263789.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87586">
        <property type="protein sequence ID" value="CUN87586"/>
        <property type="gene ID" value="ERS852471_00607"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="16"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN87586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="51017" checksum="B316C956DF18A2D1" modified="2016-09-07" version="1">MNEKSTNDKKYNVVAIASVFLLGAFVCFLNSTFMNVALSDIMKDLNISVSTAQWLSTGYMLATGIIIPFTAFLIDRFTNRTLFFVSIGLFTVGTVVGAFATNFPMLLTARLIQGVASGIIVPLMQTVFLNMFPIEKRGFAMGIVGVVIGFAPAIGPTLSGWIINSYPWRYLFYVTLPFAVIDLVIGIFLLKNVTPTRKVSFDIISFIGAAVGFGALLFGFSNAGNYAWSDKNVYIPLIIGIVFLIIFVWRQLTMKEPMLDLSVFKSSIFTFSTIIVMIVYAAMISSELIIPMFLENVKAESALRSGLTLMPGAIVMVIMNPVTGTLFDKYGARYLALGGLAILTLGTFGFSFLKVDTSITYVIIVYAIRMLGIAMLLMPLTTSGLNSLNRELYAHGNAANNTLRQVAGSIGTSIIVTLMSKSAASSGLTNPLEAQVHGMNVSFTLIAALTLLGLIIAFFVVKKKEVKVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANW9</accession>
    <name>A0A174ANW9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lipB_1</name>
        <name evidence="3" type="ORF">ERS852471_00649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90147">
        <property type="protein sequence ID" value="CUN90147"/>
        <property type="gene ID" value="ERS852471_00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="23768" checksum="C9C546E392A17CF3" modified="2016-09-07" version="1">MAFSVDYRLAPENPYPIGHTDCYSVLKWIYENAEGFGGDKNNIFVAGDSAGGNLTQYCTTRDMEDNLGMVKGQLLLYPTVNMAGIEDEYFKWSMDEYEMAPKHRAGLEMMLGMFGGMTGGLEDILGTNDVKNEYLTPYIREAKGLPPTFITVGEHDYLKVECLAYAAKLTKAGVDTTTVLYKGFGHAYGDNIGVYPQSEDCAIEMGKFILKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQT3</accession>
    <name>A0A174AQT3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfkN_1</name>
        <name evidence="5" type="ORF">ERS852471_00657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90827">
        <property type="protein sequence ID" value="CUN90827"/>
        <property type="gene ID" value="ERS852471_00657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="302"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN90827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="505" mass="57316" checksum="6B7298243FBE9386" modified="2016-09-07" version="1">MIKELKIYFTSDLHGYIYPTDYIEKSKKNIGLLNIINQFDKDGNTLIIDGGDTIQGSPFTNYLSNTEFEVHPIASIMNEGGYDFITLGNHDFNYGLDYLKNYLSNLNATCLCANVVDETGNLPILPYKIKTMENGLKVGIIGFTTDFINRWERPENIKGINITDTFDSVKEYFDVVKKQCDLTIGIYHGGFENDLDSHKKLSNTKENIAYKICAEFDFDILLTGHQHMSIANMNLHGTHIAQTPHNGSKFLKLNLTIDDNNITKITSSLEAVTLNPNKDMYEKFLSLENKVQEWLDTPVGFLDTELQPTDHLHMALNGCALANFINQIQLETSNADISCTSFANVIKGFDKNVTVRDIMSTYPYPNTLVILEVNRDILKSALERSASYFDNNNGCVTISESFLKPKVEHYNYDYFANIEYTFDLNKEINNRVTSIKYKGQELSDGQVLSLVMNNYRASGAGGYDFYQNCTVLKEILVEMPEVIINYFKSNSNVKVHKSTYLKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1D5</accession>
    <name>A0A174B1D5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263962.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94637">
        <property type="protein sequence ID" value="CUN94637"/>
        <property type="gene ID" value="ERS852471_00694"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898448at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN94637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="267" mass="31194" checksum="769D565C02A524A7" modified="2016-09-07" version="1">MYTLIKFILYFLIYSFLGWICETIYCSILDRKFVNRGFLNGPVCPVYGFGALLVIALLNKYRGDIFAIFFLGMIVTSVVEYITAVILETAFQTKWWDYSKHKFNIHGRVCLLNSTLFGLLSVVLIEVINVRITTVVNSIPKMVNVVLACVAMIIFLLDFITTLIAMIKLNKKLNDLIQVLIELKSMNIKLKELNEHEFEEVIKMLKDKNESTYVIDQLTKIYDRYKKLNVRSILQRRILKAFPNIEHKKYKEQFIGLKEIINKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2F4</accession>
    <name>A0A174B2F4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_00693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263960.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94563">
        <property type="protein sequence ID" value="CUN94563"/>
        <property type="gene ID" value="ERS852471_00693"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="611" mass="68059" checksum="B39F1057D0C8F341" modified="2016-09-07" version="1"> </sequence>
</entry>
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</entry>
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        </source>
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        </source>
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</entry>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN98679.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="588" mass="66173" checksum="60FC015EBAD12CA0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BF26</accession>
    <name>A0A174BF26_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enzyme of ilve/pabc family</fullName>
            <ecNumber evidence="6">2.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ilvE_1</name>
        <name evidence="6" type="ORF">ERS852471_00771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99103">
        <property type="protein sequence ID" value="CUN99103"/>
        <property type="gene ID" value="ERS852471_00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN99103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="32436" checksum="5B1AFF7FA7187234" modified="2016-09-07" version="1">MEVKGESLMKVEAINKFYLKDGKICEVKDFVDDNSDKGNIIYEVFRIEGGTPIFLKDHTERLQRSFSLLNLEMPFSIEEFRNNIAKVIKANDYVLGNMKMTYNILSKELKIFYIPHKYPSEKDYADGVKTILYHGERENPNIKIVNKSFRELINEELAKQNAYEAILVDRNGDITEGSRSNIFFIKDKKLITAPGQAVLLGVTRAKVMLIAKDLKIDVIERTVKESEIKDMDAMFISGSLAKVLPIAYVDDMKKDAHNEILRNIIDRYNYMVDECIKENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQH6</accession>
    <name>A0A174BQH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS system mannose/fructose/sorbose family transporter subunit IIB</fullName>
            <ecNumber evidence="9">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">levE</name>
        <name evidence="9" type="ORF">ERS852471_00826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264211.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01940">
        <property type="protein sequence ID" value="CUO01940"/>
        <property type="gene ID" value="ERS852471_00826"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696140at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00001">
        <property type="entry name" value="PTS_IIB_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018455">
        <property type="entry name" value="PTS_IIB_sorbose-sp_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00854">
        <property type="entry name" value="pts-sorbose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-4" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO01940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="158" mass="17391" checksum="2D5C0EDCD3A3E9ED" modified="2016-09-07" version="1">MPNIVLTRIDNRLIHGQVATQWCSSIGANLILVANDVVAGDKLRQGLMDMAAPSYASTRYWTLEKTISTIHKASAKQFIFIVCETPSDVLKLVEGGVPIKKVNIGNMHMAQGKRQVAGSVAVDDKDVEAFRKLKDLGVELEIRRVPTESAESLDKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQL6</accession>
    <name>A0A174BQL6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pullulanase</fullName>
            <ecNumber evidence="3">3.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pulB</name>
        <name evidence="3" type="ORF">ERS852471_00843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02883">
        <property type="protein sequence ID" value="CUO02883"/>
        <property type="gene ID" value="ERS852471_00843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011840">
        <property type="entry name" value="PulA_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02104">
        <property type="entry name" value="pulA_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="575"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO02883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1066" mass="123076" checksum="8D033D09A5EA9DD2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CB80</accession>
    <name>A0A174CB80_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trmL</name>
        <name evidence="4" type="ORF">ERS852471_00942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264447.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09499">
        <property type="protein sequence ID" value="CUO09499"/>
        <property type="gene ID" value="ERS852471_00942"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1578095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO09499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="17530" checksum="96655CFE1C9B60D5" modified="2016-09-07" version="1">MNLNIVLYQPEIPQNTGNIARTCVLTNSTLHLIKPLGFSIDDKAVKRSGLDYWSELKLEVHESYEDFINKYGDRRIFLASTHGGNYYNEESYKPGDFIMFGRESKGVPQEVHEAHTNIRVPMIKTSTRSLNLSNTVAIIAYEALRQMDFPDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CF58</accession>
    <name>A0A174CF58_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
            <ecNumber evidence="3">1.1.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lhgO</name>
        <name evidence="3" type="ORF">ERS852471_00989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264524.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11803">
        <property type="protein sequence ID" value="CUO11803"/>
        <property type="gene ID" value="ERS852471_00989"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="475" mass="52014" checksum="3793C8545125168C" modified="2016-09-07" version="1">MYDVAIIGAGVMGASIFRELSKYNVKSILIEKENDVSMGTTKANSAIIHAGYDPKIGTLMAKYNVKGNEMFEDLCKELSVPFKRNGSLVLAFNDEDLETINNLYINGSTIGVKGLKVLSKEEVLKIEPNLSHDIKGALLAPTGGIVGPFEYTIALVENGIQNGGEIILDAEVAKINKYETFVIETTNGKKIEAKYVINAAGIYSDRIHNMICKESFKITPRKGEYYVMDKSQGNLVSHTCFPCPSKLGKGVLVTPTIHGNLLVGPNAVDGEDREALNTTSEGLANIKKSAMNTTDKINFRDCIRTFAGLRAVSDSGDFIVGEDKEVKGFIDVAGIKSPGLTSAPAIAEDVVNILKDSGLTLEKNLKFNGKREQVYFMELSKEEKAELIKKDSRYGRIICRCESITEGEIIDAIHRGFGKISIDGVKRRCRPGMGRCQGGFCGPRVQEIISRELDIKMEDIVQEKSDSVILYGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPS6</accession>
    <name>A0A174CPS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264561.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15007">
        <property type="protein sequence ID" value="CUO15007"/>
        <property type="gene ID" value="ERS852471_01024"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909525at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="50" mass="5939" checksum="0FB049DBA44E40FD" modified="2016-09-07" version="1">MTDKTLKCRDCGSEFVFSVGEQEFYKEKGFTNEPTRCISCRRAKKEQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CS23</accession>
    <name>A0A174CS23_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mgt</name>
        <name evidence="8" type="ORF">ERS852471_01046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264581.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16162">
        <property type="protein sequence ID" value="CUO16162"/>
        <property type="gene ID" value="ERS852471_01046"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793788at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="7">
        <location>
            <begin position="46"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO16162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25337" checksum="7AA891E7D2197EC2" modified="2016-09-07" version="1">MKKFFIGLIGLILSIAIISVAMIAASGHTKYKEAIDTISLSDKINEIRSSDTYVEIDDISETFRDAIVAIEDMRFYDHGAIELKSLLRAILVNLREKEVLQGGSTITQQVAKNLYFDNDQNFIKKIAEMFVAFDLEKNYSKDDILELYVNIIYYGDNNYGIKEASNNYFGVEPIDLDYDQSTLLAGLPQAPSAYSLGENYELAKERQEEVIEALEKFKKLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CS72</accession>
    <name>A0A174CS72_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264582.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16212">
        <property type="protein sequence ID" value="CUO16212"/>
        <property type="gene ID" value="ERS852471_01047"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="16934" checksum="18893D2CC95D76D5" modified="2016-09-07" version="1">MKFKEITLSDIDIISNIYTETFSSEPWNEPWTKEISNKRLKQMINCEGFFGLIAYEGDSPVGMILGNEEYSFRGLEFYIKEFCTSNTVRGKGVGTFILNEFQERLKSRGVSEVWLLTSKEETTEGFYNRRGYTSCNDWVLMRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CSL3</accession>
    <name>A0A174CSL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiD_2</name>
        <name evidence="7" type="ORF">ERS852471_01050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16362">
        <property type="protein sequence ID" value="CUO16362"/>
        <property type="gene ID" value="ERS852471_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO16362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="270" mass="28996" checksum="2FD38C7EA9568FC5" modified="2016-09-07" version="1">MSKKKKTKIKLIIFASICAIICLIALMSEHIAPYDPYAQNLSEALKAPSLAHVFGTDRYGRDVFSRVLVGGRSSIFSTLALILIITIVGTVVGLYCGVYGGARDIILMRIADMFLAFPGMVFAIAVAAVLGGGMQNAVIALAVISWPKYARIARTQAMTLKNQPFVDAARLNGLSNGKIIIKHILPNAIGTIIVMSAVDIGTMMMELAGLSFLGLGAIAPAAEWGSMMNDGRSMIQTSPWMILAPGIAIFITIMCFNLLGDTIRDYFDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVH0</accession>
    <name>A0A174CVH0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
            <ecNumber evidence="2">3.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aiiA</name>
        <name evidence="2" type="ORF">ERS852471_01036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.81" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264572.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15616">
        <property type="protein sequence ID" value="CUO15616"/>
        <property type="gene ID" value="ERS852471_01036"/>
    </dbReference>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102007">
        <property type="term" value="F:acyl-L-homoserine-lactone lactonohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="243" mass="27705" checksum="DE5874D1C1D261D0" modified="2016-09-07" version="1">MKLNDNIYVLKLKATMNPNEYIYPALIAKENRLLLIDTGNPGQIDDIKKAIEEEGLCFQDLSAVVITHQDIDHVGCVKDILKELPNVKVFASENEARYINGTKMPTKVANLERNLNYLPNEAKVLYEKMKNFYSCNKVEIDEILNDGDLIPGFNEVSVIYTPGHTPGHLSLYIEEEKVLIAGDAFIIKDGNIRTTDSDLNFNDEEYYSSLRKLHNYDIREAICYHGGIYKKNINKAIEDIMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CX65</accession>
    <name>A0A174CX65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">immR_2</name>
        <name evidence="2" type="ORF">ERS852471_01057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264591.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16669">
        <property type="protein sequence ID" value="CUO16669"/>
        <property type="gene ID" value="ERS852471_01057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="190" mass="22008" checksum="A6261324557A82CB" modified="2016-09-07" version="1">MTLGEKLKEARKRGGLSQEQLAEKLSVSRQAVSKWESDKGMPDIGNLKAIATLLNISIDYLLDNDSNIDKLVIKESINLDDFVKSGRCRCKQDAVVLKKFNDADFIYPLMRKKKLTPIENVLDFITQPGIFNIAYQLKDRNEYYLIEKENQQYFVSVSKEFIETRQLSNRVNPKKFVIGDIEYKKAPYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D363</accession>
    <name>A0A174D363_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_01115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264635.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19687">
        <property type="protein sequence ID" value="CUO19687"/>
        <property type="gene ID" value="ERS852471_01115"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="15"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO19687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="423" mass="47657" checksum="8F1FD05EE0C55E8E" modified="2016-09-07" version="1">MNEKTLTKNKLWTRDFTIITIGSIISMLGNAVSGFAIGLVVLDYTNSTFLYALFMVVYNLPKIVVPLFAGPYLDRFSRKKVIYTLDFLSAAIYTGIFFFINSGNFSYGILIIVSLFIGLIDGIYMVAYDSFYPNLISEGNFSKAYSISSMIYPLSAFMVPVASFIYNSMGTAAYLFLFNAISFFIAACFEATIKYKETHMSKEEQKGFDFKGYRDDFKEGLSYIWAEKGLLVITVYFCLTMFAGNATQTVLLPFFKNNSQLFTKSTIDVVTLFTFVTGCGVIGRLIGGMIHYKFKYPTSKKFMIAITVYMSISIIEAIQLFLPVKIMMLCFFITGIMGVTSYNIRISATQSYVPDDKRGRFNGIFNMICAAGGILGQLLGGGMAEFISERSVTVIFSIFNIFAVIFVMYRGREYVKKIYNRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBA3</accession>
    <name>A0A174DBA3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264665.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21166">
        <property type="protein sequence ID" value="CUO21166"/>
        <property type="gene ID" value="ERS852471_01147"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1858718at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="16884" checksum="2774BB9E03C966D5" modified="2016-09-07" version="1">MIKVFGLGDVHLCDEGIGIRVAEVLKEKIEALGDNIEVIIGETDLSYCISKIEDNDEVIIIDSTYFMTRPGTITIKKLDECDEYITYDNLPQEESLLSLVREKKRDVLGYFIGIEISSIDASEKISKILTKKFKDICDRVYDEIVKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM38</accession>
    <name>A0A174DM38_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase component II</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pabA</name>
        <name evidence="2" type="ORF">ERS852471_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264754.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26474">
        <property type="protein sequence ID" value="CUO26474"/>
        <property type="gene ID" value="ERS852471_01233"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="22411" checksum="CD5474AFE8966936" modified="2016-09-07" version="1">MFLMIDNYDSFVYNLIRYFEELNEEVVVYRNDKITLKEIEDMGLEGIIISPGPKAPKDAGLSLNIIDRFKSEVPILGICLGHQCIGHYFGGNIIKGKEPVHGKISYIVHSGEKIFKNVKSPLRVTRYHSLIVDNESFPSCLEITSKTEDDVIMGIRHRDYHIYGLQFHPEAEMTEDGHTMLKNFIDICKNYKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM57</accession>
    <name>A0A174DM57_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hexosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24970">
        <property type="protein sequence ID" value="CUO24970"/>
        <property type="gene ID" value="ERS852471_01203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="241"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="422" mass="50018" checksum="E0D2B86D5B7AD35E" modified="2016-09-07" version="1">MDLLKKDNEKYKMKILLVNKFYYIKGGCETYYFSLKKLLEEKNNKVIPFSMHHERNFYNEYENYFIKNIDYNHSSLVQKIVGAFKIIYNFEAKRKIRKLIKDTRPDIAHLNNFNHQLSPSILSSLKKMNIPIIYTAHDLKLICPNYKMLNKNGLCEKCKGNRFYNCTLNKCVKESMLYSLINTFEAYIHYIFNSYKNIDMIITPSKFFKEKFVEFGYEEDKVRYLPNFINIEEYKPNYNFKNYYIYVGRLSEEKGIINLIKAAEKNKKYVLRIIGTGPIEGELKKYIEERNIQNIVFDGFKTGDELKALIRNARFQVIPSIWYENNPMSVIESMALGKVVVGSNIGGIPELINNDKLLFKHNDIDSMANIIREIFELTEDEVIKIGQKNRAFIEENYSKEVHYNKLMEIYEEVINKYEGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSH8</accession>
    <name>A0A174DSH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264767.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26830">
        <property type="protein sequence ID" value="CUO26830"/>
        <property type="gene ID" value="ERS852471_01240"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1768489at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15786">
        <property type="entry name" value="CPF_1278_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032619">
        <property type="entry name" value="DUF4883"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16224">
        <property type="entry name" value="DUF4883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="162" mass="19460" checksum="618B42BE2129DCF6" modified="2016-09-07" version="1">MKYFKFIIITILILSLQGCMFDNPRYLNFKSKPNDYYYSSLIYKNLKINEPFTLKVFDTDFYKYYTVDEEDKDILLNFFESLNNDNYLTDLETTDKAKYELCIEFAHEKFIINVYDTSSITLYPWDGNFEEDKISMKGVSTYNNLYSFCSYIVNKSHQRDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E987</accession>
    <name>A0A174E987_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">purM</name>
        <name evidence="15" type="ORF">ERS852471_01375</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265015.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33947">
        <property type="protein sequence ID" value="CUO33947"/>
        <property type="gene ID" value="ERS852471_01375"/>
    </dbReference>
    <dbReference type="OrthoDB" id="923547at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="171"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="334" mass="36754" checksum="B0D267031AF4CEA7" modified="2016-09-07" version="1">MLTYKESGVNIEEGYKSVKLIQNYAKETMSKYVLNGLGSFGGMIEIPEGYRRPVLVSGTDGVGTKLDIACKKRKYDTVGIDCVAMCVNDILCHGAKPLYFLDYIACGKLEAEVAADLVKGVSEGCLQSDCALIGGETAEMPGFYKEGDYDIAGFAVGVVEKEQIISGQDIKEGDKLIGIASSGIHSNGYSLVRKVFTDLDREFNGRPIYETLLEPTKIYVKPVLSILDKFKVKGMAHITGGGFIENVPRMFNGRENLTAVIEKESYKLPEIFLEMERLGVNREHMYNTFNMGIGFILCVDEKDVNEILSELKECGEEAYEIGYITPGGEGICLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAS1</accession>
    <name>A0A174EAS1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation stage II, protein E</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIE</name>
        <name evidence="3" type="ORF">ERS852471_01385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265035.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34467">
        <property type="protein sequence ID" value="CUO34467"/>
        <property type="gene ID" value="ERS852471_01385"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014221">
        <property type="entry name" value="SpoII_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045768">
        <property type="entry name" value="SpoIIE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19732">
        <property type="entry name" value="SpoIIE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02865">
        <property type="entry name" value="spore_II_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="573"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="791" mass="88131" checksum="B02329C605634FF3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBZ4</accession>
    <name>A0A174EBZ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yycG_1</name>
        <name evidence="10" type="ORF">ERS852471_01406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265061.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35201">
        <property type="protein sequence ID" value="CUO35201"/>
        <property type="gene ID" value="ERS852471_01406"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="252"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="468" mass="53082" checksum="DD0DBE41AD80D2F2" modified="2016-09-07" version="1">MKKRSIVRKLIITFASITGGVLTLVGLISTVWINVSYTEQRIEIIDKQIAIVEETVRGYLRQENDYNEVEKILTMASMASNTDGIVVDKLGYIYIVSNSKYDDIKYTKVQMPENIKSKIDEMKKYGKAVVLLKNGQLLSYVKPMYSNGEIEGSIIMIPNSAYAGKNIMWMIWISIVVAMIISGLIINYFANRLVVKPLEEINNAAKRLTQGNVNERVDVRSNDEIGQLAESFNSMAESLEKVDNTRKEFISNVSHELRSPITSIKGFVGGILDGVIPKDKETYYFKIVYEEINRLARLVNDLLDISAMEAGKFNLQKIDFDINGVISLCILNLEGKIKSKGLDVRAVFEEKRNYVIADRDRIIQVLTNLLENAIKYSNDKGQIEVTTYTKGEKIYISIFNSGENISKEDLNNIWDRFYKSDKSRTNKVSTGLGLPIVRLILSQHNEDVWVENIDGKGVKFTFSLKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EI84</accession>
    <name>A0A174EI84_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265101.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36236">
        <property type="protein sequence ID" value="CUO36236"/>
        <property type="gene ID" value="ERS852471_01428"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1409410at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020768" evidence="1">
        <location>
            <begin position="29"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="32080" checksum="84D9E46CF3EFC892" modified="2016-09-07" version="1">MTRKAKVTLLSIFLVTMTILGGCNPIESIEKKFGIRNEYFEFLNNNNVSKISIQSTRDPGFKFIVTEDSAIKNMYQLLAKSKVSESKSTLEPDYIFEFQIGEEVRNFYYVVGSDEGNFYNDNDIFTTSKRLDEGIIQNLSFIRKPRDFDYIYYQSILDVLNVIKDKIKLSDYNIGINIQGDIECLKYVFSIDLKSFLEKARKIAPNIDLVKNNDENFDLVITVKNRGYDSTNYKTKITVNDRIQKYTDEYFITAVNEFKEWNIKVSEANNKPKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIX2</accession>
    <name>A0A174EIX2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_01466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265167.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37854">
        <property type="protein sequence ID" value="CUO37854"/>
        <property type="gene ID" value="ERS852471_01466"/>
    </dbReference>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO37854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="35720" checksum="C142D507157D2B95" modified="2016-09-07" version="1">MRKEWNGKRYHSLNYFLRNKFNEKIYKISLDGGFTCPNRDGKVAKGGCTFCSARGSGDYAGSRILSINEQFADRKKMMEKKWKDGKYIAYFQAYTNTYAPVEELRQKYEEAISQENVVALSIATRPDCLDDDVVDLLEEISKKTYLWVELGLQTVNDESARNFNRGYDFEVFKEGIKKLQDRNIEVVVHTIFGLPGETKEDMLKTVDYVAHSGAQGIKFHLLHLMKGTQMVKQYESGELQLLSQEDYIDLICKGIAMLPQEMVVHRLTGDAPRESLIGPMWSLKKWEVLNSIDKALEDNDIYQGKNYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3I6</accession>
    <name>A0A174F3I6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysE_2</name>
        <name evidence="2" type="ORF">ERS852471_01571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265374.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44261">
        <property type="protein sequence ID" value="CUO44261"/>
        <property type="gene ID" value="ERS852471_01571"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO44261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="21446" checksum="0C6062416585CBFA" modified="2016-09-07" version="1">MKDIIIIGAGGIAREVAWIIEEINEINKEWNILGFVDDNEEVWGETFNDYKVLGGIDYLNNLKEKPYVVVAMANPKVKKCIVEKLRNYFRFATIVHPSIRMSRFIEVGYGTIVYPGVILTVNTKLGNHVIVSGNCGIGHDTKIGDYSSILWGSNFSGYDVVEDDCLIGVGTSVIQGMKIKQGSILGAGSVVNTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F530</accession>
    <name>A0A174F530_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group 1 glycosyl transferase</fullName>
            <ecNumber evidence="3">2.4.1.250</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshA_1</name>
        <name evidence="3" type="ORF">ERS852471_01566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.250" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265364.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44028">
        <property type="protein sequence ID" value="CUO44028"/>
        <property type="gene ID" value="ERS852471_01566"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="227"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="404" mass="46280" checksum="CC7AF670F08D18CF" modified="2016-09-07" version="1">MKILQINSVCGYGSTGRIATDLYKVLEEQGHECIIAYGRGMAPEGFRTIKIGTNFDNYIHVAKTRLFDKHGFGSTKATKEFIKKVEEYDPDVIHLHNIHGYYINIEILFDYLKRANKKVIWTLHDCWAFTGHCAHFDYVGCNKWQTNCGKCIQKKQYPKSSLVDNSEKNFIRKKQIFNEVNKLRIVVVSNWLKEVVKQSMLRNNRIDVIYNGIDLNIFKKSTGEVSRKKYKLDNKFVILGVATIWDKRKGLDDFKKIASKIDKESIVVLVGLSNKQIESLPDNIIGINRTDNINELVDLYSCADVFVNTSVEETFGLVTIEAMSCGTPTIVYNSTACPELVDNSCGIVVEKSNIEEILSAIKEVKEKGKDYYSNSCIERVKRLYNKADIYDKYISIYKNMTNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEH2</accession>
    <name>A0A174FEH2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-bound protein LytR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvhJ</name>
        <name evidence="5" type="ORF">ERS852471_01635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48121">
        <property type="protein sequence ID" value="CUO48121"/>
        <property type="gene ID" value="ERS852471_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="109"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="358"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO48121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="50817" checksum="548FDC11A214C06E" modified="2016-09-07" version="1">MAGNGDKNRPNKDPRLITRSAREDFERKKELRKKAKRRARVRLTIVVLILLLLVLITTMFFSVISFILALRKNDLQEGITPRKNEPVNILILGMDIGDAEQDENKAIRRTDTMMVLNYNPNTKKINIVSIPRDTLIQVDAYDEYGNLRPYWKINNAYVLGGEEEVIKHVESLLETNINYMVEIDYNAFRSFIDAIGGVDMYIEQQMDYDDDAQDLHIHFNAGETVHLDGKKAEEFFRWRKNNDGTGFIDGDLGRIRNQQAFMKEVLKKCLSPTIIFKLPKILDVVKENIDTNMPGDKMISYGLKFLTNSGISMNTLQGYDEIIYDESFLIVDPSMNRELLASIKSGEVLEDDKSRADYNILVLNGTRINGLAGSVKTEMQYIGYYAVEVGNAEKRSKSIIMCNDKTLKEQLKIDTGIDNFQKNNSEEYSSYDAVIILGEDFDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGK0</accession>
    <name>A0A174FGK0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M50</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">spoIVFB</name>
        <name evidence="9" type="ORF">ERS852471_01646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265515.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48657">
        <property type="protein sequence ID" value="CUO48657"/>
        <property type="gene ID" value="ERS852471_01646"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="92"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="33403" checksum="92F37FE95C595774" modified="2016-09-07" version="1">MKFKRWKQILLSEFLLVAVLINIDKTFLLSCICILIHEFSHILVAKMKGSKFNNLQFHIYGAKVELMDLEELTNKDKLIIYMSGAMSNIIIMIVSAILFKYTNKEIFEILFKLNFGLAFFNLLPAYPLDGARIMEIILSRKITYKRAQKIISIISYTIAAFFILISVSAAIFLKKFNISLFLIGIIMIDITSTEEEATMYILMGNVFKKRSNIIRNGFIENRTISVYYKQGLVKLLTYIDKNRFNSFYVLDDDMKLIYVLNEDELVEALKIYGNISLEDYVKNKNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FL01</accession>
    <name>A0A174FL01_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">minE</name>
        <name evidence="4" type="ORF">ERS852471_01649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265520.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48835">
        <property type="protein sequence ID" value="CUO48835"/>
        <property type="gene ID" value="ERS852471_01649"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2038628at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO48835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="89" mass="10135" checksum="5F1C00497B9E4FA5" modified="2016-09-07" version="1">MNFLKVFSNKVTPKEVAKDRLRLILIHDRGSLAPEMLDKIREEILEVISKYIEIDGEDVDISFNRAEDEEGNSGPALVANIPIRNLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FL42</accession>
    <name>A0A174FL42_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhdE</name>
        <name evidence="3" type="ORF">ERS852471_01657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265536.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49190">
        <property type="protein sequence ID" value="CUO49190"/>
        <property type="gene ID" value="ERS852471_01657"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="188" mass="20795" checksum="4B5EF661BF70688B" modified="2016-09-07" version="1">MHYILASASPRRQELLTKIVDNFDVIVSNFDEDSVKFNGDVEDYVKTLAEGKGKDVASQAKKDSIIIAADTVVVIDGKILGKPKNADDAYNMLKLLSNKIHRVYSGIAVINTTNNIMKSEAVFTEVKFSELTHEEIINYINSKEPLDKAGAYGIQGLGALFVEKINGCYYNVVGLPLNRLNKIIKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTX2</accession>
    <name>A0A174FTX2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">dCMP deaminase</fullName>
            <ecNumber evidence="8">3.5.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_01720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265643.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52266">
        <property type="protein sequence ID" value="CUO52266"/>
        <property type="gene ID" value="ERS852471_01720"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1544522at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO52266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="164" mass="18245" checksum="EBAEE3651A43CF86" modified="2016-09-07" version="1">MKRETYLKWDDYFMSVALLSGMRSKDPSTQVGACIVNSSNIIESIGYNGLPKGCSDDEFPWAREGETLDTKYLYVVHAELNAILNAKGKDLSGCTIYVALFPCNECAKAIIQSGIKEVVYLSDKYADTDSVKASKKMFNATGVKLRQLTPKEKNIHLSMDIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G176</accession>
    <name>A0A174G176_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Viral A-type inclusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265762.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56234">
        <property type="protein sequence ID" value="CUO56234"/>
        <property type="gene ID" value="ERS852471_01782"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1555198at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO56234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="247" mass="29018" checksum="EBB18B8581CD4DF3" modified="2016-09-07" version="1">MKLFGKVTSNIEENENLTPEATEKKENILDLEVIKFVINEFPQLGEDIKDALDNLINTLDKSIDIIEDRSTEVIKVSRDYKLSGKYRETSQKLYEINKDINEYINWMDKNLKNHNGKNIAIEKVENVEKEKVTYDEENALDADEIKLDDYIEKFIYEDFTGYEPCKLKLENYEECVDGWDDTIVKTADILNKKFKCDKNLNFNNINTDKKVIGKKSKQNDSRDIIIEMLEDHNISLSNFKMYIKMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDQ3</accession>
    <name>A0A174GDQ3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">engD</name>
        <name evidence="4" type="synonym">ychF</name>
        <name evidence="7" type="ORF">ERS852471_01856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265905.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59657">
        <property type="protein sequence ID" value="CUO59657"/>
        <property type="gene ID" value="ERS852471_01856"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="40466" checksum="7AFABB6671C760BA" modified="2016-09-07" version="1">MRLGIVGLPNVGKSTLFNAITKAGAESANYPFCTIEPNVGVVSVPDKRLDVLEKMYNTKRKVYTAVEFYDIAGLVKGASKGEGLGNKFLSHIREVEAIVHAVRCFDDGNVVHVEGSVDPIRDIETINLELIFADLEVLERRMEKGVKLARSGDKKAKAEYEIMEKVKAHLEANKPIRTLEVTEEEDAFIKTLFMITSKPVLYSCNISEDDMMSGNLENDYVKKVKEYAENENSGVVVVCAKLEEELSGLEDDEKAEMLEEYGLEESGLDKLIRASYKLLGLISYLTAGVQEVRAWTIKEGTKAPAAAGKIHSDIERGFIRAEIVGYDDLVACGSEAAAKEKGLYRLEGKEYVMKDGDVVNFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGB3</accession>
    <name>A0A174GGB3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ctc</name>
        <name evidence="6" type="synonym">rplY</name>
        <name evidence="9" type="ORF">ERS852471_01868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60198">
        <property type="protein sequence ID" value="CUO60198"/>
        <property type="gene ID" value="ERS852471_01868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO60198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="21529" checksum="A79C453C79F89BF7" modified="2016-09-07" version="1">MSSLELKIRDKNIPNSAKKSRKNGNIPGVLYGKAINNLMFEVGDLEFIHEISSTGEHGIIDVLLNGENHKALIKEIQRDPATNKIIHLDLEELKGKDKIVSSVPIHYVGEEYINRRGTVLQKEKDSVKIECNVDSLPKFINLNVGDGTVGSVYKLGDLEVASEISILDDLNSVVAAVSYERKTVSDDMDAVEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GL88</accession>
    <name>A0A174GL88_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265992.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61928">
        <property type="protein sequence ID" value="CUO61928"/>
        <property type="gene ID" value="ERS852471_01912"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1988859at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="86" mass="10468" checksum="576FEAAD9E09E9FF" modified="2016-09-07" version="1">MDKYDYVFKWLKSATKPERHIDEMEAFAKKHPIIFMKFHKDSSKIVNNDINDEKYIKAKEELTKLFDENEEDFRPVFNAIKSKFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS82</accession>
    <name>A0A174GS82_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266027.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63295">
        <property type="protein sequence ID" value="CUO63295"/>
        <property type="gene ID" value="ERS852471_01925"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1852638at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="114" mass="13159" checksum="7E2173A27456A140" modified="2016-09-07" version="1">MKLKLEKNLKIINEMVTYFKKLGNKNIHLDFNSDETKSHFLISGDVANISTEKLNQLNTILNRPRQQEVEECYWQLGGESEVECELTLIGVMVDSAKVEYNGKILTVELIREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GT79</accession>
    <name>A0A174GT79_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lptB_2</name>
        <name evidence="5" type="ORF">ERS852471_01950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266072.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64318">
        <property type="protein sequence ID" value="CUO64318"/>
        <property type="gene ID" value="ERS852471_01950"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO64318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="28174" checksum="BAF4A2DE941FBCE8" modified="2016-09-07" version="1">MLKANRLTIKFGGLVAVSDFSIEIGDKEVVGLIGPNGAGKTTIFNMLTGVYTPTEGTISYLGEQINGLKPYVVTSKKLARTFQNIRLFEKMTVMDNVKISYDYRVKYGYFDAIFRTKKFRKIENKMDEEVRDILDTFNLLDKANEKAGNLSYGEQRRLEIARALATNPKLLLLDEPAAGMNPQETMQLSELIKSIRDKFNISILLIEHDMKLVMGICDRISVLDYGKKIAEGAPEEIKTDKRVIEAYLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWE7</accession>
    <name>A0A174GWE7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC</fullName>
            <ecNumber evidence="1">2.7.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tagF</name>
        <name evidence="1" type="ORF">ERS852471_01971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.12" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266106.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65170">
        <property type="protein sequence ID" value="CUO65170"/>
        <property type="gene ID" value="ERS852471_01971"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1162846at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="382" mass="45994" checksum="932D581937B472B3" modified="2016-09-07" version="1">MRIIKYGIDISKIILCKAISIVMKVNRNNRDIWLIGERKDEAKDNGYHLFKYVREKHPEQKIYYVIDKNSNDIRKIEKYNNIIYHGTFKHYLYYVLATKLICAHQSSTIPDSPVCWKLGQYGFLKKKKIYIKHGIIKEKIKSHMYENTKFDMIICGAKPEYDFVKSELGYPEENVKYLGLCRFDNLHNFKVKNQILVMPTWRAWFGSTWGKESDDDFLKSEYFKNYEDLITSRELEKYLKKNGVNLIFYPHYEMQRYLKYFTTNSERIIIADSKQYDVQTLLKESKLLITDYSSIAFDFAYMKKPIIYYQFDKDEYDKRHYSKGYFDYKRDGFGPVTSNVDELVRNIKVIDNEEKYIYKVSKFFEIYDNQNCMRTYKEVCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYV6</accession>
    <name>A0A174GYV6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof family hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywpJ_1</name>
        <name evidence="1" type="ORF">ERS852471_01992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266145.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65979">
        <property type="protein sequence ID" value="CUO65979"/>
        <property type="gene ID" value="ERS852471_01992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="31386" checksum="E8D0AFB7F9845E15" modified="2016-09-07" version="1">MRKMLASDLDGTLLFKGKVSDENKEALKKFKTHGGIFSLSTGRAYNEIESVIKDMDIKPDYFILNNGALILDGNADIIHISNLDYKAIKEIISYLKKYTDMVSIQTGFKSYFIVSKLTKLKIKIRIIIKNFTYGLKYKDERTYVRNLDDIQNAKNETFTLMAANLKGYPIEKIQEIADYINDNYGDYVECYRNTIFLDIVPKGCSKGYGVKRVGEIANLNMDNVYTIGDSWNDDSMFQVTKNSFTFTYAEEGLQKKTTHVVETVAQCIDKYILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2V1</accession>
    <name>A0A174H2V1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pleC</name>
        <name evidence="8" type="ORF">ERS852471_02066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266289.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69352">
        <property type="protein sequence ID" value="CUO69352"/>
        <property type="gene ID" value="ERS852471_02066"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="853"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1075" mass="123865" checksum="0C4ED5D01775BFF5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4V2</accession>
    <name>A0A174H4V2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266220.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67825">
        <property type="protein sequence ID" value="CUO67825"/>
        <property type="gene ID" value="ERS852471_02024"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1825724at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="103" mass="11419" checksum="598D6EF9924C4576" modified="2016-09-07" version="1">MRKVKIKVLKATCNKELAKQYGHDDNYTSCPVLKEGQEFYTTGIFGNDIPAGFCHMAWQALVMPVNVLIGGGKVLGFDDVHIACCTDGLRPVIFELSVVEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAW3</accession>
    <name>A0A174HAW3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266336.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70507">
        <property type="protein sequence ID" value="CUO70507"/>
        <property type="gene ID" value="ERS852471_02095"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1710333at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="18264" checksum="3F6CF1A930C6BEB1" modified="2016-09-07" version="1">MDKEYNSNIFRTYKLDYFGKYHFYEENELVKEKEDGEYILENLKKSNRFDYNGASYTFTKFGNISEGRTEKDVDLTIKENDYNVDINGEVVHLDLIYKMDIKKLEDHYRITTRISEKGDTVSCLLYIDLENGEDFINGLNHVKEAQIELSRPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HG36</accession>
    <name>A0A174HG36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane lipoprotein TmpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tmpC</name>
        <name evidence="5" type="ORF">ERS852471_02169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266482.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73824">
        <property type="protein sequence ID" value="CUO73824"/>
        <property type="gene ID" value="ERS852471_02169"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023421" evidence="3">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="37"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO73824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="364" mass="38856" checksum="5F8C88A4C82A4E6B" modified="2016-09-07" version="1">MKKRAIALALSALVLTGLVGCGSKSEGGQTPAEDAMKVGMVTDSGTIDDKSFNQGTWEGIIKAESELGIDKNYIKPAGETEADYLKEIQNLYDTGYKFIVTPGFKFETAVFQAQTKYSDAKFVILDGAPHSGDYNNVIADNTVSIMFAEHESGFLAGVATALELQDGELGFIGGLEIPAVQRFNWGFQQGVAYANENLGTKMSIKEENVKYANSFADIPAGKQLAATMYDRGVKAIFCAAGGTGLGAINEAKERVSNGNEVWVVGVDVDQYADGIYDEANNKSVVLTSAMKKIDTATFDVIKAELDGEFPGGEQLTFDAKNDGVGIPAENPNLSKETTDKVAEVFEKIKSGEIVVSGEQGDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNR6</accession>
    <name>A0A174HNR6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDGSH-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266570.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75861">
        <property type="protein sequence ID" value="CUO75861"/>
        <property type="gene ID" value="ERS852471_02228"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667004at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="153"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="351" mass="40905" checksum="57A4C11390165417" modified="2016-09-07" version="1">MPRVNNVIKQVSQLNTHEQGKVFEFLKTVLMSNGFTNSIDKEIAENRFNKGKCCPFCNHDKISKYGKYHGKNGVKQRYKCQNPECKKTFNDFYKSPVSSSKKGLDKWLLYAQCMVNGNTIRQCAEIVEINIATAFFWRHKIIDAIRKFIGYGSLEGVIELDETYFALSYKGNHSKSSNFTMPRESRKRGKEINTRGISKEFACVLCGVDRLGNIYTGLICNGRPKYSDIDRALSEVVEENSILCTDKHRSYIPFATQHNFELHQIRGGRKAVDIYNIQRVNAFHSSLKRWIKKFNGVSTKFLTNYLFWYKWTQLFKTEMERNKPKKFFIHANSTHSISLIKDFKIRRPIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HV46</accession>
    <name>A0A174HV46_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS system mannose/fructose/sorbose family transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">manY</name>
        <name evidence="8" type="ORF">ERS852471_02252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266618.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76715">
        <property type="protein sequence ID" value="CUO76715"/>
        <property type="gene ID" value="ERS852471_02252"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456742at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00822">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO76715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="262" mass="27661" checksum="BDA9C02C4883912C" modified="2016-09-07" version="1">MSTIQIILIFIVACISGMGSVLDEFQTHRPLIACTLVGLILGDLKTGIIIGGTLEMMALGWMNIGAAMAPDAALASIISTIIVISGKQEMGAGIALAVPLAAAGQVLTIFARTITVFFQHQADKYAEKGDLKGIDMCHLLALIIQALRVSIPALIVAIFIGTEAVQNMLNAIPQWLSGGLGVAGGFIVVVGYAMVINMMEAKYLMPFLFLGFVVAAFTDFNLIALGVLGTVAAIVYIQLNPKYNESKTVTVVSNTDNDDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HWJ3</accession>
    <name>A0A174HWJ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Staygreen protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205692.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79362">
        <property type="protein sequence ID" value="CUO79362"/>
        <property type="gene ID" value="ERS852471_02317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024438">
        <property type="entry name" value="Staygreen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12638">
        <property type="entry name" value="Staygreen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Staygreen" evidence="1">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO79362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="30189" checksum="4275708CFBCB1BAA" modified="2016-09-07" version="1">MSKFIPEKLFVEYKDIDINNKKDRKYTLTHSDETADLFLTIDKKYNYEKTNETRDEVLAEWKESDGRYILKVYLQISLDSDLSKTIIRDKIFREELPLALKAIVYGDKEFLKENSELYKAKVIVSFKSDTPKYNKVEEWGIVLDYLGDYSRCNKGISKLHVRDTKNNEIEEALIRVLALYIKIQVNIFAGRDATYCLRDAELLYSKKINKDDYLQDEYEVAIGLKIGIPTPIYNNFIIIFLIKDNVINIKDSKMINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1H8</accession>
    <name>A0A174I1H8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">melR_3</name>
        <name evidence="5" type="ORF">ERS852471_02313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266717.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79218">
        <property type="protein sequence ID" value="CUO79218"/>
        <property type="gene ID" value="ERS852471_02313"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="34885" checksum="41218D098A88E7EE" modified="2016-09-07" version="1">MVDVQESDQVIKVFNVGDTVYFEYKNEYEPFEKIGEPWINDPHNICTYCDQFSTGNGVIGRHWHESLEIIYMVQGSIEVTTANGNILVGDGEAIVIGGTTLHGIKSISSSGNHQCLHIKYDFLLKYLNRDDFTLKIFKISNISKFLFYYENVIKHIEVNNYISQMKYKANLLLLLTTIVEDENYAKENIVTSNFNDTINKIIYYINFNYKENITLNYVAEKFNYTPQNISILFKKCLGKTFHKYLTEIRLENAVHLLLNSDKKVIDISLECGFPNEMAFINKFKLKYNMTPNAYRKNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2T5</accession>
    <name>A0A174I2T5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266745.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79907">
        <property type="protein sequence ID" value="CUO79907"/>
        <property type="gene ID" value="ERS852471_02330"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1595370at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO79907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="177" mass="20637" checksum="67B90D08C8F19056" modified="2016-09-07" version="1">MKYYLVALFDDESYKNLSPIQRNLSKKYRANRNSPIPYIPLEILENPNIDKLNTVVDKIVKPYKNFKVEVSSKVSICDSSKTLNLEIEDVGYIKRLNRLLSDNLQLHGFNVKGIESDKNLQLTLANISYNNKDNKRVIAPLDSRFNLSTLKVNRLELWKISNTRRETLIQTYPLKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I437</accession>
    <name>A0A174I437_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">csd4</name>
        <name evidence="6" type="ORF">ERS852471_02360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266788.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80746">
        <property type="protein sequence ID" value="CUO80746"/>
        <property type="gene ID" value="ERS852471_02360"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010969">
        <property type="entry name" value="Cys_dSase-rel_unknwn_funct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01977">
        <property type="entry name" value="am_tr_V_EF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="3"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO80746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="385" mass="42400" checksum="5BAB7C3A47CA26CB" modified="2016-09-07" version="1">MNVYLDNASTSFPKPKSVSDSIYNYLTNIGGNPGRANHSNALESNRYLFLARETIANFFNFHKIENVIFTNNITSSLNILINGILKPGDHIITSSMEHNSVIRPLYNLKENIGIDLEIVSAKSNGILDVNSISKAIKPNTKLIVITHASNITGSIQPIQRIGELCKKNNIFFILDSAQSAGVLEVDFKKFNLNALAFTGHKSLLGPQGIGGFIIDDELNKICNPYILGGTGSLSHSLTQPDFLPDKFESGTLNIPGIIGLYEGIKFIEKEGLNTIYEHNSYLRSYLINEISNINNFNIYGDLDPSNGTSCVSITHNNLDVSELSYILDSDFGISNRSGLHCAPLAHQTIGTYPNGTVRLSLGYFNTLDEIKYTVDSLNKINKLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I7D7</accession>
    <name>A0A174I7D7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnulose-1-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rhaD</name>
        <name evidence="5" type="ORF">ERS852471_02407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:19689"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58313"/>
            <dbReference type="EC" id="4.1.2.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. RhaD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.19" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266872.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83084">
        <property type="protein sequence ID" value="CUO83084"/>
        <property type="gene ID" value="ERS852471_02407"/>
    </dbReference>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00770">
        <property type="entry name" value="RhaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013447">
        <property type="entry name" value="Rhamnulose-1-P_Aldolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="4">
        <location>
            <begin position="10"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO83084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="30504" checksum="ADFDF03CCF8AD0CA" modified="2016-09-07" version="1">MRLNNVNFIKNFMKITEDAWEKGWHERNGGNITYRLTPEDIKEISLSIKYNNGWNRIGVKVPNLANEYFLVTGSGKFIRNISVDLESNIGIIKIDETGEKYKIVWGLINGAKPTSELPSHLMSHSIKFDVTGGKHRVIMHSHATNLIALTFVLPLDGAVFTRELWEMATECPVVFPTGVGVVPWMVPGGAEIAEATSKLMKKHDIVLWAHHGVFCSGEDLDLTFGLMDTVEKSAEILVKVLSMGGKRQTINSNNFRELAKDFNVTISEEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBU4</accession>
    <name>A0A174IBU4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_02394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266853.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82590">
        <property type="protein sequence ID" value="CUO82590"/>
        <property type="gene ID" value="ERS852471_02394"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024141" evidence="8">
        <location>
            <begin position="32"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="12"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO82590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="419" mass="44973" checksum="0082CBE25875BCD2" modified="2016-09-07" version="1">MNNKNRSIKHLIVLIVCCGLAASSIGVCVNSAGVFYTPVSESLGIMRGTFSMHGTISLLATAVISLFVPAIMKKYSYKVILIFSVLVAGGSTILMAFSKGVLAFYILGAIRGVSSGLFAIVPITMIINKWFYKNHGLATSIVLSFSGIAGAVCSPIFTKCIQSFGWEIAYIIMGISIIVLCIPAVIYPFSIDPEEIGLLAYGYNAKEKQIIDEVTKSENNFNFFNVSFVCFFVFAILHTAISGITQHLPGFAETLNYSATIGAMMLSAGMVGNILSKLVIGFISDKLGPVKATIIMIAINIISIVILLLAPSSTVLLIGSFLFGSVYSVGAVGFALLTKHFFGVENYSTVYPIISFATNFGGAFALSLVGYIYDFTGSYVYAFIIALTINVANLILLYIVVKSYLVAKKLKLENAVVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBZ5</accession>
    <name>A0A174IBZ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00266 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266952.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84762">
        <property type="protein sequence ID" value="CUO84762"/>
        <property type="gene ID" value="ERS852471_02453"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO84762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="27862" checksum="73D05E73468601CA" modified="2016-09-07" version="1">MVHDIDYKIHGNEMQFVEIVLDPRETVVAEAGAMMMMDNSITMETIFGDGSEKSKNGGLFGKLGGAAKRVITGESLFMTAFTNQGYERESVAFAAPYPGKILPMDLKALGGALICQKDAFLCCAKGISLGIAFTKRLGAGFFGGEGFILQKLEGDGLAFIHGGGTIVRKTLIPGQILKIDTGCLVAMTKNVSYDIQFVGGLKNTVFGGEGLFFATLTGPGDVWIQSLPFSKLADRVISAAPQLAGRSKDEGSILGGISNLFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IDS1</accession>
    <name>A0A174IDS1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266930.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84316">
        <property type="protein sequence ID" value="CUO84316"/>
        <property type="gene ID" value="ERS852471_02440"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="19390" checksum="174C46B3C4DC3B1B" modified="2016-09-07" version="1">MNLRLANMYDLPKIKVVYGKIIDNMNKNNIQIWNEIYPCEVFYDDIVNNRLYVLTENDEIVSAFALSNSNLGEEYMKWGNKNAKALYIDRFGVNVNYLRKGIGSVMINKAIAIARDSSAKYIRLFVVDINKPAINFYLKNGFKQVDGIYEERIDDFVLSEYGFEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFA0</accession>
    <name>A0A174IFA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266896.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83609">
        <property type="protein sequence ID" value="CUO83609"/>
        <property type="gene ID" value="ERS852471_02419"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1460177at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO83609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="25406" checksum="9170B4B42A9F76D0" modified="2016-09-07" version="1">MKPIYKNIGNSYEVKDNVVYITILKKDGTELITKIDEDDLALINDMGTWFAEWNKDYNNYIAQNISKTKKNSKNKPLKQSIASVLLKVSPKAPIKYLNGDTLDNRRCNLDIAKKNSGNEYEEKDENTISIILKDKLDKKEGYALISKEDLALVINDTYSWVLHKTHGNVSVVANTPEGRLPLWKVIMKPQENQYIEFKNHNPLDNRRSNLILKNHEEENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IWH5</accession>
    <name>A0A174IWH5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavoprotein subunit FccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fccA2_1</name>
        <name evidence="6" type="ORF">ERS852471_02576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90731">
        <property type="protein sequence ID" value="CUO90731"/>
        <property type="gene ID" value="ERS852471_02576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024644" evidence="4">
        <location>
            <begin position="31"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO90731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="641" mass="67257" checksum="A0989BA26A9292B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IWI1</accession>
    <name>A0A174IWI1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric siderophore ABC transporter,substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yclQ</name>
        <name evidence="3" type="ORF">ERS852471_02567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267149.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90416">
        <property type="protein sequence ID" value="CUO90416"/>
        <property type="gene ID" value="ERS852471_02567"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01140">
        <property type="entry name" value="FatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033870">
        <property type="entry name" value="FatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO90416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="312" mass="33946" checksum="F3A60052CA2FED2D" modified="2016-09-07" version="1">MKNKSMIIGIILVLLIAAGITIPKFVGGNSEPVSETITITHELGETPVTTNPQKVVVFDYGILDALDSLGVNVTGVVQSGLPDYLTKYAGEEYSSIGTLKEPDMEAIFALTPDLIIISGRQADYYEELNKIAPTIHLGIDNADYLGSFKNNMDILGQIFGKEKEVSSKVEEIEKTIAELNAKVTEKNINGLITLANDGAFSVYGQESRFGIIHKEFGVTPVDTTIDAGTHGQKATFEYVAEKNPQYLFVVDRAAVTGGNTSAKELFDNELVARTDAYKNDNIVYLDPTIWYTSVGGFTSTLRMVEEVDAAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J4S8</accession>
    <name>A0A174J4S8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267282.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93661">
        <property type="protein sequence ID" value="CUO93661"/>
        <property type="gene ID" value="ERS852471_02644"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2217950at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO93661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="12683" checksum="C0ECFD6B35A35D85" modified="2016-09-07" version="1">MQMNDIIDGLNSCDCPTGLQGTNFNSVSGCGFGSWIWILLILFYTNQGANYGGGGCCCKPRKNDCCCCGNSGYNNAGYGSGCGGYLFLLVILFLCGGCGNNFGGCNTFGSGFDQGFDALGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JG48</accession>
    <name>A0A174JG48_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpsT</name>
        <name evidence="8" type="ORF">ERS852471_02705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117965.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96608">
        <property type="protein sequence ID" value="CUO96608"/>
        <property type="gene ID" value="ERS852471_02705"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO96608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="87" mass="9427" checksum="2E45463A50BD016F" modified="2016-09-07" version="1">MANIKSAKKRIKVTEKKTLENRMVKSALKTAIKKFEAAVAANNAEEAKALFVKAAKSLDMAAQKGTVHKNMAARKKSRLAAKLNAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JGE4</accession>
    <name>A0A174JGE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205701.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96190">
        <property type="protein sequence ID" value="CUO96190"/>
        <property type="gene ID" value="ERS852471_02695"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2076861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="52" mass="5737" checksum="DF4A6E4B3422B662" modified="2016-09-07" version="1">MNKNESIKCSVQQCKHHANSADYCTLNAIQVGTHEANPTVPECTDCKSFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPQ4</accession>
    <name>A0A174JPQ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99029">
        <property type="protein sequence ID" value="CUO99029"/>
        <property type="gene ID" value="ERS852471_02757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO99029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="51" mass="5766" checksum="6B05C829F5102ED4" modified="2016-09-07" version="1">MEIEEKKKNEENKTVRDTIYGRIDVSVKTMDKVIIGLMIVLASSIILGVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQI5</accession>
    <name>A0A174JQI5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267545.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00426">
        <property type="protein sequence ID" value="CUP00426"/>
        <property type="gene ID" value="ERS852471_02791"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1372955at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="26594" checksum="8A764FA1E8265FD6" modified="2016-09-07" version="1">MIIRENIIELEEQELDYILERDDVKFKPEELIFFDLEHYVYKKPKCVGVFGACVFDEKDKKLHVTQYMIEGKNDVVDILILAKKYFIKMKEEGKKAIVTFSGNNDFTVINYLFNKYGIYYDFTKEYESVDIQKEYEMDKKTSIGLKNLEKVFGIHRESELISGSNLAKTFHKVLKDKEYIERMPSEKIENILLYNEQDVVSLYSMFISWRKYINPIEEMNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JSP6</accession>
    <name>A0A174JSP6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">ERS852471_02832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267631.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02782">
        <property type="protein sequence ID" value="CUP02782"/>
        <property type="gene ID" value="ERS852471_02832"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP02782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="25405" checksum="759428D44C901F86" modified="2016-09-07" version="1">MIEFKGVSKIYNNNVKALSDVNVKIDTGEFVFLVGPSGSGKSTFIKMLLKEVEPTTGDVIVADKKLADITRKQVPYYRRKIGMVFQDFRLIPNLNVYENVAFAMRVVEASPREIRKRVPTVLSLVGLSHKYKMFPNELSGGEQQRVSLARAIVNNPSVLIADEPTGNLDPETAKEIMDLLKDINTAGTTIVMATHAKDIVDTMKKRVIAIESGNIVRDDSRGMYENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZE5</accession>
    <name>A0A174JZE5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative FtsW-like protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rodA</name>
        <name evidence="7" type="ORF">ERS852471_02825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267619.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02480">
        <property type="protein sequence ID" value="CUP02480"/>
        <property type="gene ID" value="ERS852471_02825"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP02480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="406" mass="45123" checksum="8A0B68C74CA8AD0A" modified="2016-09-07" version="1">MKVLKKEKRLLKLIYLLCLLLFVNLGFLEQPYDKFAIIMGVILCVLIGYSHFVIRRFYPDGDKFILIFASILAVIGIATLYRLDKILAIKQLVWVTLGMVGYILIVAILPDLRSFAKYKKIYMIITLILMPLALIFGTTVGGAKNWIEIGPFMFQPSEFGKIALVLYLASSLATYENKETFKEDFKSLLEPALVTMFSLACMVLQADLGSALIFFGISVTMLYVATAKKKYVFTCLGLSAVGATAAYFLFAHVKRRVKVWLDPWAYRYDEGMQIVQGLYGIASGGLFGSGLGQGYPEYIPVNDSDFIYAVICEEFGIIFAIGIMIVYFLLFYRGIRAAFVTNDKFSQLIAVGFSTMIACQTLVIIGGIFTVIPLTGITLPIISYGGSSILTTFFALGILQKISEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5I9</accession>
    <name>A0A174K5I9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dedA_3</name>
        <name evidence="2" type="ORF">ERS852471_02868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267698.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04550">
        <property type="protein sequence ID" value="CUP04550"/>
        <property type="gene ID" value="ERS852471_02868"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP04550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="166" mass="18647" checksum="082A3A054AA4488A" modified="2016-09-07" version="1">MTNLIETLKANTLVIIFIIMFLEALNLTGIPAIVIMPAVGVFIKSSGHSFLIVFAIATLGSILGSITYYLVSSKFGDIIYNFFYNKFPSTQKSLRKAKETAEKYGAKMCLIGRMLPTIRTFISLMSGIFKVKFKDYIIYSSIGIFVWNLVLMSFGYFGYILSTMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9W0</accession>
    <name>A0A174K9W0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rubrerythrin</fullName>
            <ecNumber evidence="6">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbr1_2</name>
        <name evidence="6" type="ORF">ERS852471_02931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267809.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07216">
        <property type="protein sequence ID" value="CUP07216"/>
        <property type="gene ID" value="ERS852471_02931"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP07216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="22743" checksum="CF27CC08B4FA9BB8" modified="2016-09-07" version="1">MVDFKNSRTKENLMRAFAGESQARNRYTFAADATKKEGYQILHDLFIYTANQEKAHAWQFMKKLKELSGQEIEITATYPAEVESSTLTLLKSAAKHESAEHDEIYKSFAETAKEEGFMDIYTLFNNIASVEKVHSERFNNYATMLENGSLFKATNKLQWMCTNCGYIYEGESAPAKCPVCEYTQDYYIRFNESPFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KD77</accession>
    <name>A0A174KD77_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase, NADH oxidase subunit</fullName>
            <ecNumber evidence="6">1.18.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rubB</name>
        <name evidence="6" type="ORF">ERS852471_02989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.18.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267925.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10054">
        <property type="protein sequence ID" value="CUP10054"/>
        <property type="gene ID" value="ERS852471_02989"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015044">
        <property type="term" value="F:rubredoxin-NAD+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="313"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP10054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="407" mass="45120" checksum="415B6EA60043CDDD" modified="2016-09-07" version="1">MRYIVVGASAAGISGAKTLRELDKEAEIILVSKDDYVYSRCILHHYLDGRRTIEDLDFTPRKFFDLYNIKWMKGIEVIGIKPKEHKLTLDNGEELSYDKVLLATGSSSFIPPVPGLREGNNVVGLRNLDDAIKIKDVAEKCKNVVILGAGLVGVDALAGLVDYDIKLTMVEMGDRILPLQLDNYAAKVYQDMLTDKGVDLKLGVRAEQLVLDNDNNPVELLLNTGEKIPCDLVIACTGVRSNVGFLKDSGIETDKFGLIINEKGETDTKDVYGAGDITGRNPIWPTAVKEGIIAANNMYGKELYMTDFFGSKNTMNFLGLATMSLGVVVKPDDSYEEVIDCDGKDYKKVIYKDGKIYGAIIQGDLSYAGVLTQLIKEKIDVSKVKKPLFDIDYADFFNIKENLEYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KK85</accession>
    <name>A0A174KK85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267986.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11241">
        <property type="protein sequence ID" value="CUP11241"/>
        <property type="gene ID" value="ERS852471_03021"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2203242at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026180" evidence="1">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="222" mass="25375" checksum="BF8FCD52082EA2A1" modified="2016-09-07" version="1">MKMNKILAGLVLAGVCGVGLTAMASSNDGSMNKTVEVKPVNTNTSKYTGGNVTTSEIENYLVNKYGANWATDLLAKNGDRWDEVLENELEAYFGIKYDDLIDYVIEREENELGIDDIDDYDYYTSEEIGKRDEIIKAIESKYGTNWANDLFAKNGEAWDEILENELENQYGQKYDDVIEDIIDLKEHEAGLDLDHDDYDYDDYDDIDDINDFDDIDDHYDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKM3</accession>
    <name>A0A174KKM3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="9">PGP-I</shortName>
            <shortName evidence="9">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pcp</name>
        <name evidence="12" type="ORF">ERS852471_03015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267974.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11046">
        <property type="protein sequence ID" value="CUP11046"/>
        <property type="gene ID" value="ERS852471_03015"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1927224at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="23022" checksum="926DF7340FB01FD6" modified="2016-09-07" version="1">MKVLITGFDPFGGESVNPALEAVKLLPETISGAEVIKLEIPTVFRKSLAKIEEAMELHNPDIVISIGQAGGRFQVTPERVAINIDDARIKDNEGNQPLDIIIFEDGEAAYFSNLPIKAMVQEMKENGIPAAVSNTAGTFVCNHVMYGILYMIDKKFPNARGGFIHVPYIPAQTLDKPDKPAMNINDIAKGLELCIKAAVENSEDIKAVGGAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKR4</accession>
    <name>A0A174KKR4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein ERS852471_02998</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267943.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10408">
        <property type="protein sequence ID" value="CUP10408"/>
        <property type="gene ID" value="ERS852471_02998"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015368at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP10408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="10840" checksum="FC5428B6F67D4496" modified="2016-09-07" version="1">MLILTTDTVPGKEIIEIKGLVKGSTIRCKNIGKDITAGFKNLVGGEMTGYNDMLTEARQIAIGRMVDEAESMGANAIIGMRLMSSSVAAGAAEMVAYGTAVVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KL81</accession>
    <name>A0A174KL81_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobB_1</name>
        <name evidence="4" type="synonym">cobB</name>
        <name evidence="6" type="ORF">ERS852471_03003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class U subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267951.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10568">
        <property type="protein sequence ID" value="CUP10568"/>
        <property type="gene ID" value="ERS852471_03003"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01968">
        <property type="entry name" value="Sirtuin_ClassU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028628">
        <property type="entry name" value="Sirtuin_class_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP10568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="26923" checksum="9B230409F6410656" modified="2016-09-07" version="1">MTNEIEVLSKIFKESNNIVFFGGAGMSTESGIPDFRSSNGLFNEKLNLTFTPEQLVSHSFYMRYPEEFFNFYKSKLIYPDAKPNAGHIALAKLEKMGKLKAIVTQNIDGLHQAAGSKNVFELHGSVLRNYCVKCHAFYDEKFILESKGVPTCIKCGSRVKPDVVLYEEGLDDNVIRGAVNAIANADTLIIGGTSLVVYPAAGLINYFRGKNLVLINKSTTQADSKANLVIRDSIGKVLSKAVSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLQ7</accession>
    <name>A0A174KLQ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dmsB_2</name>
        <name evidence="6" type="ORF">ERS852471_02990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267927.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10100">
        <property type="protein sequence ID" value="CUP10100"/>
        <property type="gene ID" value="ERS852471_02990"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="15499" checksum="26FE066CC99F9CE7" modified="2016-09-07" version="1">MKRIKIDRKKCIGCLTCTTACIVSHGSEDTRSRIAINSDGRYSPIFCRHCDRPECVYTCMTGAMRRDDDTGLVLYDKSRCASCFMCIMACPYGVLKMNHLNNKEVMKCDMCRETESGTPQCVAKCPMAAITLEEVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KND0</accession>
    <name>A0A174KND0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">asnA</name>
        <name evidence="5" type="ORF">ERS852471_03006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267957.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10700">
        <property type="protein sequence ID" value="CUP10700"/>
        <property type="gene ID" value="ERS852471_03006"/>
    </dbReference>
    <dbReference type="OrthoDB" id="487853at2"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00645">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP10700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="38729" checksum="D097275B082D7108" modified="2016-09-07" version="1">MKKTTIIPKGYKPTLNLIETEVAIKKIKDFFETNLAESLNLTRVSAPIFVKGGQGINDNLNGVERVVSFDAMEIKDSQMEIVQSLAKWKRMALKRYKFEVGQGLYTDMNAIRRDEELDNLHSLYVDQWDWEKIIRKEDRTEETLKEVVNKIYEVFKVTESYMHLTYRQLTPILPKDIKFITSQELEDMYPKLTAKEREDAITKNFGAVFIMKIGGKLKSGEKHDGRSPDYDDWQLNGDILFWSPVLDRAIEVSSMGIRVDEEALAKQLDESGCNERRELDFHKALLNGELPYTMGGGIGQSRICMFFLKKAHVGEVQSAVWTDDIIRECEDGGIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KUC3</accession>
    <name>A0A174KUC3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14471">
        <property type="protein sequence ID" value="CUP14471"/>
        <property type="gene ID" value="ERS852471_03079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="267"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP14471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="354" mass="40768" checksum="09522D6B77017E35" modified="2016-09-07" version="1">MEELIAYTICFAFILFGIKESINLLNTHKNIKYPINRTLYYLSILLSFLIINSNLNTILADIIKISSNYFAFYTIRNELIRILLLVLIYFIVHFIIYTLLKFVVKLLYLYKISQKKISIFISGILGGIKGIIVTLIMFIGIVIFNVTIGRNFPINIFSNISGYSMIYDTISQNFNSSNSKIIYSDENKYIPTSNVLIYYNGVTLEDGVKSNNEINNKAIEITKYKESDLEKAKSLYVWIGSNIEYDFDKAYKTLNNESSGNSGATEAWITRKGICFDYACLYVAMARAVDLKVRLVTGSAYDGTQYGPHAWNEVYLEKEERWVPIDPTFYMAGNYFDNSNFYDDHIKEMIAGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXI0</accession>
    <name>A0A174KXI0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ywqD_4</name>
        <name evidence="10" type="ORF">ERS852471_03130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268184.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16964">
        <property type="protein sequence ID" value="CUP16964"/>
        <property type="gene ID" value="ERS852471_03130"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="33"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP16964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="229" mass="25436" checksum="6C2A52FBD76B4F31" modified="2016-09-07" version="1">MFVVEKKPKSVAAESYRTLRTNIQYSSFDKEYRTIVITSSEPGEGKTVTSGNLSLALAQGESKVLLVDCDMRKPTIHKNFKISNQDGLTDLLLHKKTMEQVMVKYNENLTIIPAGRVSPNPSEMLGSRAMSAFLEEMKNHFDYIVMDTPPLGAVTDAQVLSTKVDATILVVKAGDTKRDVVMNSVNLIKKVNGNLIGTVLNGVEKSNNKYYYYYGSEEVAATAEKKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZM4</accession>
    <name>A0A174KZM4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268121.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14975">
        <property type="protein sequence ID" value="CUP14975"/>
        <property type="gene ID" value="ERS852471_03090"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="67" mass="7402" checksum="530B88B2434BCDA3" modified="2016-09-07" version="1">MDIVHYNVTGLINNSTKTQIKNALDKIDGIQEVCVDLGRSSIEVAFNESVTEAEVRNCIEETGFSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LDI2</accession>
    <name>A0A174LDI2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rplA</name>
        <name evidence="10" type="ORF">ERS852471_03232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268360.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22454">
        <property type="protein sequence ID" value="CUP22454"/>
        <property type="gene ID" value="ERS852471_03232"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP22454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="229" mass="24457" checksum="A13714682A800A01" modified="2016-09-07" version="1">MGKKYVESTKLIDKSVLYTPSEALDLAVKTAKAKFDETVELHVRLGVDPRHADQQVRGAVVLPNGTGRSVKVLVFAKGAKAQEAQEAGADFVGAEELVQKIQGENWFDYDVVVATPDMMGVVGRLGRVLGPKGLMPNPKSGTVTFDVAKAIAEIKAGKVEYRVDKTAIVHCPIGKVSFGVEKLQENFHALMEALIKAKPAAAKGQYVKSVSVSSTMGPGAKINPTKVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LFB7</accession>
    <name>A0A174LFB7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ylxp-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268330.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21416">
        <property type="protein sequence ID" value="CUP21416"/>
        <property type="gene ID" value="ERS852471_03212"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="95" mass="10902" checksum="541B9DB7888A3ACD" modified="2016-09-07" version="1">MKVLVLVIKLRASWVHSLKEKRMILLSITKRLKNKYNVSVGEVGEQDTHKIIQIGISQVATSKDVLYASKEDIITFIEENCEAEIIDIEEEIIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LWE5</accession>
    <name>A0A174LWE5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized hydrophobic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000039">
        <property type="protein sequence ID" value="CUP26030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268460.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26030">
        <property type="protein sequence ID" value="CUP26030"/>
        <property type="gene ID" value="ERS852471_03290"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1371086at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="47573" checksum="B2E64D5B41DD00A8" modified="2016-09-07" version="1">MNFNMDRFRYEFTRNQASNEEIYATILEGMNVHGSNFIILMCAIIIASIGLNMNSVAVIIGAMLISPLMGSIIGIGYGVGTYNTKLLKTAFRVLSISIIISVVTSTVYFSITPITTAGSEILARTSPTIWDVIIAFVGGVAGMIGLTRNKPSNVIPGVAIATALMPPLCTAGYGIATKQLNIFLGAGYLFFINGFFIAISTFVVTKALKLTTKSNVDYEKESKVRRFILISSIIVMIPSMVSAIWMITKTIDEKDLNDFISNELKNQYVLSKNIDYKNNIITLVTVGDSINSTELNFLNEKMIDYGLKNKKLILKQEGINMSNLEQYIDSIKNNQRYITSNNTDTNNKEEINRNAIFNELKSIYPEINKLYLGYIYGENDEENNIEILIIYSDVEDFSKNIGNIENWFKTRINSNNAKVYIEGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNK4</accession>
    <name>A0A173XNK4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262791.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53279">
        <property type="protein sequence ID" value="CUN53279"/>
        <property type="gene ID" value="ERS852471_00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="152" mass="17773" checksum="6EA6A2F6A9897271" modified="2016-09-07" version="1">MKLTRRQITLKVLSNFINSNLDKINDVEMKANNITFMTNSGKINIKIKTSKDYTENEENKHCLWVSFSKEELENSEDNDYFVVICSDNLEKSLVFTRNELVAHFSNISKRKKNDEIDYDMYPHFIGRSCVDSRVKSDATPIDITKNLNNYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRN5</accession>
    <name>A0A173XRN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262807.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53596">
        <property type="protein sequence ID" value="CUN53596"/>
        <property type="gene ID" value="ERS852471_00088"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861869at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="18481" checksum="DEBCE7EE185140C4" modified="2016-09-07" version="1">MSPYYRYKKEKFMEKYQNAYDNLNDLKEAINEYSKNPNRIIRRAMFAFFQDFSEYIVDMCESYIIINDGRIKSSSTSLNLIEQAYELGFFDKDLKEYLIFSVKLRNRYTHDYYKREESEKQIEQFCFQELSKLDIFLEESKDKVVLKYIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XW03</accession>
    <name>A0A173XW03_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262849.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54588">
        <property type="protein sequence ID" value="CUN54588"/>
        <property type="gene ID" value="ERS852471_00110"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08352">
        <property type="entry name" value="VOC_Bs_YwkD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037478">
        <property type="entry name" value="YwkD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="128" mass="15128" checksum="84621FCF8F4D1AA1" modified="2016-09-07" version="1">MQFKKIHHIAIICSDYKTSKEFYVEKLGLRIIREIYREERDSYKLDLEIGDSQIELFSFPNAPKRPSYPEAQGLRHLAFEVDDIEKAVEELKQKGIKTEPIRVDECTGRKFTFFEDPDKLPLELYSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XW09</accession>
    <name>A0A173XW09_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262857.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54805">
        <property type="protein sequence ID" value="CUN54805"/>
        <property type="gene ID" value="ERS852471_00115"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1334297at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="62"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN54805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="238" mass="28336" checksum="D73F36654306233E" modified="2016-09-07" version="1">MLKRVINEVKKYEYKLDLLWLILFPMFNVIYFITNHIHKEGFDLTIALDRMIPFVPIFIIPYVYWYLYMIIGFLILSLNDRKKYMRCILGLYLGMFFSYTIYLIFPTEIVRPTVTGNGILSSIVKIIYSLDRPFNCFPSLHVLGTYFIMRYTKKENSQYVYYYTQTVGILIILSTIFIKQHFVLDAVASMLIVELINIIVKKISEENLEKYLKIPYEIVERLTHKSQKFSEVSSNEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1Q5</accession>
    <name>A0A173Y1Q5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluB_1</name>
        <name evidence="5" type="ORF">ERS852471_00182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262985.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58122">
        <property type="protein sequence ID" value="CUN58122"/>
        <property type="gene ID" value="ERS852471_00182"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN58122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="27856" checksum="352C0877DC795005" modified="2016-09-07" version="1">MEERLQKYIARCGVASRRKSEELILSGQIKVNGNVITELGTKVNVDTDIVEYGNKVIKPEEEKIYIMLNKPEGYITSVSDEKGRKTVLDLIDVNERIYPIGRLDYDSSGLLLLTNDGDIYNKIIHPRVAIDKKYIAVCEGKFTEKEIEKFKNGVDIGGYVTSSANIEIIDEETVTLKKTGENIIRSTVEITIHEGKNRQIRRMCSSLNHNVLKLKRVSVGNIKLGNLKKGSWRLLTQEEVNYIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3R0</accession>
    <name>A0A173Y3R0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9 10">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">miaB</name>
        <name evidence="14" type="ORF">ERS852471_00190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9 10"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263000.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58539">
        <property type="protein sequence ID" value="CUN58539"/>
        <property type="gene ID" value="ERS852471_00190"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="147"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="380"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN58539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="50672" checksum="BFC682061B35A5F4" modified="2016-09-07" version="1">MQETNLKYYIETWGCQMNEEDSEKLSGMLKNIGYSRTENKEEAGIILFNTCCVRENAENKVFGNLGQLKALKKKNPDLIIGICGCMMQQEGMADKILSTFPYVNIVFGTHNAYKFPEYLNRVKTEGVQIKEIFNKEEEIVEGLPIDRKSDVKAFVTIMYGCNNFCTYCIVPYVRGRERSRKSEDILNEVKELVKAGYKEITLLGQNVNSYGKGLDEDINFAKLLRMINEVEGLERVRFMTSHPKDLTDDVILAIKECDKLCEQIHLPVQSGSNNILKKMNRHYTREYYMELVNKIKKEIPGVSLTTDIIVGFPGETEEDFLETLELVKEVGYSAAFTFIYSRRNNTPADMMLNQVDDADKHHRFDRLVKAVNDNVIKLNKEFENQVVEVLVEGMSKNDETKFSGRTRNGRLVNFEGENVKIGDLVNVEITRAQPFSLLGKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSI9</accession>
    <name>A0A173YSI9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Primosomal protein N'</fullName>
            <ecNumber evidence="10">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">priA</name>
        <name evidence="13" type="ORF">ERS852471_00309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263237.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66884">
        <property type="protein sequence ID" value="CUN66884"/>
        <property type="gene ID" value="ERS852471_00309"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="212"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="464"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN66884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="735" mass="84906" checksum="B9CB4ABE126FA0F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWN2</accession>
    <name>A0A173YWN2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">ERS852471_00339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263289.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68612">
        <property type="protein sequence ID" value="CUN68612"/>
        <property type="gene ID" value="ERS852471_00339"/>
    </dbReference>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN68612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="32932" checksum="1C656E9372C5B67C" modified="2016-09-07" version="1">MFGKLFDSLKTGLTKTRNALTDKINETLKLAVTIDEDLYEELEEILIMADIGMDTTMDIIERLKDKIRKEKINDVEMVQPALKEVIAEMMKGTDEVVDESGKKVVLVIGVNGVGKTTSIGKLAAKNKQAGKKVLLAAADTFRAAAIDQLVVWSERAKVDIVKHGEGSDPAAVVFDAINASKARNVDLLICDTAGRLHNKKNLMDELGKINRIIEREYSGVKKETLLVLDATTGQNAVIQAKQFMEVCPVDGIILTKLDGTAKGGVVISIKNSLNIPVKYIGVGEGIEDLQEFDAESFVEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z2P7</accession>
    <name>A0A173Z2P7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rssA_1</name>
        <name evidence="4" type="ORF">ERS852471_00363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70023">
        <property type="protein sequence ID" value="CUN70023"/>
        <property type="gene ID" value="ERS852471_00363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="13"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="319" mass="35897" checksum="179CB723BCC36169" modified="2016-09-07" version="1">MITKKIDDINIGLVLSGGGAKGAYEAGVFKAMWDLDIVKNISVISGTSIGTVNGLMFSMDDSNVLESSWANVSYSRFILNEDSIRNKNISDAVKRIYTGEKATIETHLARQGDIGLLSQSGVKQFIEEYINMNEIKKCNRTIYACAYNINLGHPEYFRLNDYSEDEVIDITLASCAIPFIFKPIQFKGYKYADGGINNPKYPNKNADNVPIKPVINHKCDLIIVIYLSHKDKIDKKYFKDNNIIEIYPSAHLETIQGMGTINLNQSTLNDRVELGYRDGLVALSPIVIALIKGRNIEELIKRNNENNNNLLNRFKLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z4S3</accession>
    <name>A0A173Z4S3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263377.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71402">
        <property type="protein sequence ID" value="CUN71402"/>
        <property type="gene ID" value="ERS852471_00389"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1420919at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="151"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN71402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="32577" checksum="CD8A84B2A5F041AA" modified="2016-09-07" version="1">MSELSNRTKGIIFIIASAFGFAMMSAFVKLAGDLPSFQKTFFRNLVSCIIAAIFIIKNKESFFGKKDSQKILILRSIFGTIGIVLNFYAIDKLVLSDANMLNKLSPFFVIIFSALFLKEKINIKQSIAIIIAFLGALFIIKPTFNLDIIPSLLGVVGAICAAAAYTCLRVLGGKEKHYTVVFYFSLFSTIVIFPFMIVVYKSMTMIQLVYLILAGIFASIGQFGVTLAYKYAPSKEISIFDYSNIIFSAIISLVIFGVLPDYLSVIGYLIIFGASFYMFLYNKKLDKLEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5G4</accession>
    <name>A0A173Z5G4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase and metal dependent phosphohydrolase</fullName>
            <ecNumber evidence="6">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpfG</name>
        <name evidence="6" type="ORF">ERS852471_00383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.52" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263370.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71097">
        <property type="protein sequence ID" value="CUN71097"/>
        <property type="gene ID" value="ERS852471_00383"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="277"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="5">
        <location>
            <begin position="398"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN71097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="585" mass="67563" checksum="B08EECF2D54D7D2F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6I4</accession>
    <name>A0A173Z6I4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="9">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="9">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">fabZ</name>
        <name evidence="10" type="ORF">ERS852471_00378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263360.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70805">
        <property type="protein sequence ID" value="CUN70805"/>
        <property type="gene ID" value="ERS852471_00378"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="15223" checksum="841D71FD42B1EA8A" modified="2016-09-07" version="1">MDIKEIMEIIPHRYPFLLIDKVESLEGNKIVAIKNVTMNEYFFQGHFPVEPVMPGVLIVEALAQAGAVALLKREEFKGKIAYFGGINNAKFRKKVVPGDILTLEVELTKIRGVAGIGKGIAYVDGKKACEAELTFMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z863</accession>
    <name>A0A173Z863_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenylhydantoinase</fullName>
            <ecNumber evidence="5">3.5.2.-</ecNumber>
            <ecNumber evidence="5">3.5.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hydA</name>
        <name evidence="5" type="ORF">ERS852471_00414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.-" evidence="5"/>
    <dbReference type="EC" id="3.5.2.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263419.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72582">
        <property type="protein sequence ID" value="CUN72582"/>
        <property type="gene ID" value="ERS852471_00414"/>
    </dbReference>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="49"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN72582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="461" mass="51730" checksum="556513D24887FDEF" modified="2016-09-07" version="1">MSLLIKNGIIVTASDIYNGDIYIEKGRISEIGLELLKDADKIVDAKGMYIIPGGVDVHTHFNLDVGIARANDDFYTGTIAAACGGTTTIVDHMGFGPKNCNLKHQVDVYHKYADNNAVIDYSFHGVIQHIDENILEEMKSIVEDEGISSFKAYLTYDYKIEDEDMVKIFKRLNELDSITTVHCENHGSIKYLREKFTKEGLKSPKYHCLSRPEEAEGEAVNRMINIAKIAGDSPLYVVHLSTKLGLDYIKMARGRGEKVYAETCPQYLILNEEKYELDNNEGLKYIMSPPLRKSYNCNELWRGINEGYIQTIATDHCPFSFSKDKQLGKDDFTKCPNGAPGVEERIPLIFSEGVMKEKISINKFVEVCATNPAKIFGLYPKKGTIQVGSDGDLVIIDPNREKVLSANNLHSNVDYTAYEGIKVKGYPIMTISNGEIIYDKGKFIGKKGRGKFIKRDKVNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z911</accession>
    <name>A0A173Z911_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263429.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72811">
        <property type="protein sequence ID" value="CUN72811"/>
        <property type="gene ID" value="ERS852471_00419"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532167at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="234"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN72811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="407" mass="46169" checksum="ECE6685139749F4F" modified="2016-09-07" version="1">MRKKWSIFYGALCIIVIIVSFKYFMFVKNSNFKGEEFVSTKSKNNDELKSKRLIKLKGEDTFNKGELQDIEISKEEGEDVLTLLKEGDTYSELGTYISEEIDTEDFTNLILSWNSKTPENTYIEVLARAYVVERNKAIGKWSEYLSWGIWGSTINSSSANSKCEIAKVDTDVFVLNDKSNNVAKKLQIKVKLYSADSNNTPTISQITATFIDTVGAKEVFSKEVDEIYCENTIETPCFSQYEREESIASRICSPTSLTMVLNGMGENLMVEDVAWNCYDYMYKGFGNWTFNVAFAGSLGYESYIEYGSLEALQREILKGYPVIVSVKYTNDENNKDYPYIENSPVTTSGHLIVVCGITSDSNGQTYVVVNDPAGKNNESVRRKYKLEEFLLAWSKSNNAMYVINKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDF1</accession>
    <name>A0A173ZDF1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263485.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74432">
        <property type="protein sequence ID" value="CUN74432"/>
        <property type="gene ID" value="ERS852471_00449"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1432587at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="22030" checksum="54F2CD274C5B32DC" modified="2016-09-07" version="1">MKINLILLASGNSKRFNGNKLLTNFHDKPLYMYTLEKLKGIKGLNKIIVVTQYEDIKQKSIDLGFDVVLNFESELGISNSIALGISRDKSADGYMFMVCDQPFIKPKSINKLIEEFNSGGKGICSIGFKDRLGNPNIFSRKYLEELLSLKGDIGGKHILKKHIDDLKIIQIEDEEELKDIDTRDDIDSKSTNKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFH3</accession>
    <name>A0A173ZFH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbgT transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">abgT</name>
        <name evidence="2" type="ORF">ERS852471_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263503.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74991">
        <property type="protein sequence ID" value="CUN74991"/>
        <property type="gene ID" value="ERS852471_00460"/>
    </dbReference>
    <dbReference type="OrthoDB" id="350103at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015558">
        <property type="term" value="F:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902604">
        <property type="term" value="P:p-aminobenzoyl-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004697">
        <property type="entry name" value="AbgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30282">
        <property type="entry name" value="PTHR30282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03806">
        <property type="entry name" value="ABG_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="520" mass="56488" checksum="B77FF6C5CE8F09D6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4J3</accession>
    <name>A0A174A4J3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">padR</name>
        <name evidence="2" type="ORF">ERS852471_00538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263661.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82446">
        <property type="protein sequence ID" value="CUN82446"/>
        <property type="gene ID" value="ERS852471_00538"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="12258" checksum="9E032FA69A1BFB89" modified="2016-09-07" version="1">MANSTQMLKGLLEGCILKIVSTDETYGYAVCEKLIQYGFEDISESSVYPILIRLEKKKLLYSKMKKSPLGPMRKYYYLTDAGIKELDEFIDTWNFVKRNVENVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMD4</accession>
    <name>A0A174AMD4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-X-X-Leu-X-X-Gly heptad repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263822.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88645">
        <property type="protein sequence ID" value="CUN88645"/>
        <property type="gene ID" value="ERS852471_00624"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408193at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017770" evidence="2">
        <location>
            <begin position="27"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="862" mass="90792" checksum="165B804C06277F73" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ARY6</accession>
    <name>A0A174ARY6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">melR_2</name>
        <name evidence="4" type="ORF">ERS852471_00651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263864.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90280">
        <property type="protein sequence ID" value="CUN90280"/>
        <property type="gene ID" value="ERS852471_00651"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="181"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN90280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="303" mass="35868" checksum="FEB2BD471D083ABE" modified="2016-09-07" version="1">MNGVTYEKVNLNPNIPAMLGYWGKENIDAKSAFYIGPHWHRSIEITFLTEGQVEGVINGRSIKVNCGDFIFVNSGDVHEIEKKQGKLCGGIILVLSYDFIKSVYPNIDNIRFDIYKKSNSKKRLVDIFLTIKDIYLNPEELDYIKINSYLYEILYILLSNFTVEDDNSNLENYFKYRDKQKEILMYIGENYREELSLDKISKQFYMSSEYFSRKFHEWFGVTYKMYLANYRLSKAYEDLINSDDNIQDIALTHGFLNVKSFINIFKEKYNMTPSKYRQLINCQETAEKWTRNYNNKLIKNDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBA0</accession>
    <name>A0A174BBA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="4">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">garR</name>
        <name evidence="4" type="ORF">ERS852471_00740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.60" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264042.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97459">
        <property type="protein sequence ID" value="CUN97459"/>
        <property type="gene ID" value="ERS852471_00740"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="162"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN97459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="30464" checksum="DBD594EFB11A4473" modified="2016-09-07" version="1">MKIAWIGVGVMGKSMALNLKKAGHSVSVYNRTLSKCEGLEDEGIRVCETIKDCVEGADAIFTIVGYPKDVEEVYLSEEGIFANAKEGAYMVDMTTSSPALAKKLSELGTKFHVLDAPVSGGDIGAKNGTLSIMVGGEKADFDFLLPVFESMGKNIIYLGKAGSGQNCKACNQIAIAGTIAATAEAVHYAESVGLDGKTVLEAISKGAAGSWQMDNNAPKMLVHDYEPGFFIKHFIKDLKIARDTMESKNEELPVLNKVLELYEKIADDGLEDEGTQAIIEYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BU06</accession>
    <name>A0A174BU06_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of Uncharacterized Function (DUF1540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264244.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03108">
        <property type="protein sequence ID" value="CUO03108"/>
        <property type="gene ID" value="ERS852471_00847"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1787593at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="105" mass="11284" checksum="6DF2092B6353D8E1" modified="2016-09-07" version="1">MAEINCSVNNCSHNKSGVCYSNRVNIGGLNSSCSKDTCCGSFLDKNLYSDLTNNTNASGSCDALICKVENCKYNCNSLCDLPCISVGGDDVKIYSEAHCQSFQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUP4</accession>
    <name>A0A174BUP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_4</name>
        <name evidence="7" type="ORF">ERS852471_00862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03879">
        <property type="protein sequence ID" value="CUO03879"/>
        <property type="gene ID" value="ERS852471_00862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO03879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="31514" checksum="B5645856B068F5D6" modified="2016-09-07" version="1">MRYMAKSKVKIGTILLYVILIALTILFLAPIFMVLMNSFKGKLYISSEPFKLPTSVTFVGLNNYIGGITKTNFLISFGYSLFITIASTVVIIFFTSMTAWYITRVKTKFTGFLYYLIVFSMIVPFQMVMFTMTKIANMLHLDNPVGIIVLYLGFGAGLSVFMYCGFVKSIPVEIEEAAMIDGCNPIQTFFFIVVPLLKPITITITILNVMWIWNDYLLPYLVLGSEYKTIPTAVQYLRGGYGAIDMGAMMALLVLAIVPIVIFYLTCQKYIIEGIAAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUU6</accession>
    <name>A0A174BUU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic sulfatase-maturating enzyme</fullName>
            <ecNumber evidence="8">1.8.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264256.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03368">
        <property type="protein sequence ID" value="CUO03368"/>
        <property type="gene ID" value="ERS852471_00853"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034485">
        <property type="entry name" value="Anaerobic_Cys-type_sulfatase-m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00289">
        <property type="entry name" value="anaerobic_Cys-type_sulfatase-m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO03368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="43512" checksum="2432EA8D1763F716" modified="2016-09-07" version="1">MKRNISLMIKPSSSKCNLKCKYCFYHSIADARDIKDYGFMSKETLRQIVSKVDDYCDGGNCNIGFQGGESLLVGLDFYKELVKCTTEINNGTKFNYHIQTNGTLINDEIAKFFKENNFLVGVSLDGTKEIHNLNRIDPLNRDTFNSVMKGINILKKYDVNFNVLIVVTSALCKKIDSVYKFLKKNDFKYLQFIPCLDPLEIENGQTYSYSLNVEEYSKFLLNLFNLWYKDIMEGNYVSIRYFDNIVSLFLGQDYESCDMRGICSCQHIIESDGSMYPCDFYTYEKYSIGNILEETFDEIHHKNETINFMKESLNKNNKCSICRFKNICRGGCRRHRENSQDNMNYYCSAHYEFFSKTLDRFEIVANKLRRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4B6</accession>
    <name>A0A174C4B6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ORF">ERS852471_00913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264389.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07994">
        <property type="protein sequence ID" value="CUO07994"/>
        <property type="gene ID" value="ERS852471_00913"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="18097" checksum="0FA08D9D6A01F45B" modified="2016-09-07" version="1">MARIKNSNSLAENRKARHDYFVEETMEAGIELVGTEVKSIRNGKCNLKDCYADVKNGEIFILNMHISPYEQGNIFNVDPLRERKLLLHKEQIGRLAGLVSREGYTLVPLSLYLKNGRVKVALGICRGKKNYDKRDSMLEKAHKRDIEREMKNRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C592</accession>
    <name>A0A174C592_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccpA_2</name>
        <name evidence="5" type="ORF">ERS852471_00896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264354.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07045">
        <property type="protein sequence ID" value="CUO07045"/>
        <property type="gene ID" value="ERS852471_00896"/>
    </dbReference>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="36985" checksum="B42D1DAF8ECD9155" modified="2016-09-07" version="1">MALNIIDIAKLAGVSKSTVSRYLNSGYVSEESRSKIQKVLDETGFQPQRHAKSMRTKKTNLIGVIVPKISSETIARVVEGMTDIFSPKGYDVLIANTNLSIEKEIEYLNIFKNNNVDGIIFIATKVTDAHIKVMNDVQVPIVVVGQEINGYPSVYHDDYNAAKDSVKYIIDKGHKNIGFVGVYKEDISVGHYRTKGYIDGIIESGIKLNENYIKIGEFSSESGYNLAKEIMENDKDVTAILAVTDNIAVGVIEYLRENNYRVPEDVVVMGMGDSRISKVITPKLTTIHFHYKTSGRKSAEIMCEILGNGINSSKNLYKNIKLNYGLIERDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CKK3</accession>
    <name>A0A174CKK3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12480">
        <property type="protein sequence ID" value="CUO12480"/>
        <property type="gene ID" value="ERS852471_01000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025373">
        <property type="entry name" value="DUF4363"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14276">
        <property type="entry name" value="DUF4363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="12685" checksum="E7BC439F99D8A3BC" modified="2016-09-07" version="1">MFYADFKFKSLCTDIVNICDEMEESIKTDNVEVSFEKAMDLFDMIQDRGAIAAIYINHMDYDVMLNEALKLSVYLENDDISESEASLHLLKYSTKHMKELQVPNIENIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CMA7</accession>
    <name>A0A174CMA7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ORF">ERS852471_01008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264540.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12875">
        <property type="protein sequence ID" value="CUO12875"/>
        <property type="gene ID" value="ERS852471_01008"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16258" checksum="1E2C05BF9FD52B49" modified="2016-09-07" version="1">MKVMVINGPNLNMVGVREKGIYGTRSFEDICDYIKDEANKRNIEVELYQSNIEGDIINQIHKCYYEDFDGIIINPGAYTHYSYAIHDAIKSVNINTVEVHLSNIHAREEFRHKSVTAPACIGQICGFGEIGYILAMDALKKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWS4</accession>
    <name>A0A174CWS4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17951">
        <property type="protein sequence ID" value="CUO17951"/>
        <property type="gene ID" value="ERS852471_01083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO17951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="406" mass="45087" checksum="BD7328D23389E8B7" modified="2016-09-07" version="1">MMDKKKVIVVGAGPAGIMAALNAAKNNDVILIERNNEIGKKLKLTGGGRCNITNKRDIEEFFNRVVNNSKFLYSSFYNFTNEDLLAYLDECNFEYKVEYDNHNKVYTSSDKAEDFIELLKNNLAKAKVKILYNKQVTDLIVEDSIIKGVVTDDNNKIYGDKVIITTGGKSFPVTGSDGSMFEVLERHGHKINQLYPALVPLVIKEEFVKRLQGISMKDVVFRAKVKKKKIEVTGDMIFTHFGISGPGVLILSSYINKALENGEIEVTLDFLRDKSKEEISALIRSNPNKTVLNNMKGLLTQSFLKEIIENLGLTTTKAAELKKADEMKLIEFIKEMKLTVRETLSIKAAQVTSGGVAVKEIDASTMESKLIQGLYFAGEVIDVDAETGGFNLQIAFSTGTLAGSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXH2</accession>
    <name>A0A174CXH2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17717">
        <property type="protein sequence ID" value="CUO17717"/>
        <property type="gene ID" value="ERS852471_01079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="44" mass="4972" checksum="623BA9F3CE6A851B" modified="2016-09-07" version="1">MEPLVPVIFLGYFNIALYLAIAGLGIYILILIIKAFKIYIKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2M1</accession>
    <name>A0A174D2M1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein CotJB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cotJB</name>
        <name evidence="2" type="ORF">ERS852471_01088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264612.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18258">
        <property type="protein sequence ID" value="CUO18258"/>
        <property type="gene ID" value="ERS852471_01088"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1848060at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024207">
        <property type="entry name" value="CotJB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12652">
        <property type="entry name" value="CotJB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="CotJB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="82" mass="9789" checksum="1638AE51B3929F87" modified="2016-09-07" version="1">MYDNPLVIDIMKYMFYAVDLNLYLDNFPENSKATKDYKMISEKLDCLIRQYEETYGPLTNFGSSSIEDPEKWTSCPWPWENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9Y2</accession>
    <name>A0A174D9Y2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 7-alpha-hydroxysteroid dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264659.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20818">
        <property type="protein sequence ID" value="CUO20818"/>
        <property type="gene ID" value="ERS852471_01140"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="28850" checksum="29732D8B57AA2520" modified="2016-09-07" version="1">MNLNDKVALVTSATRGIGFASALKLAENGATVYMGVRRLEATQEIVDKYPNLKMIPVFFDAYKVESYKEMVQTVIEKEGKIDILVNNFGTGRPEKDFDLVNGDEDAFFEIIESNLGSVYRISKLVVPHMINTGGGSIVNISSIGGSVPDISRIGYGVSKAAVNNITQQIAMQYARNNIRCNAVLPGLTATDAAIDNMPEDFRKSFLSHVPLNRMGTPEDMANAVLFFASDMSSYVTGHIMEVSGGYHLGTPQYADFVGRKMVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DGE0</accession>
    <name>A0A174DGE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264700.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23030">
        <property type="protein sequence ID" value="CUO23030"/>
        <property type="gene ID" value="ERS852471_01187"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2164246at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="294" mass="33895" checksum="0B986F1975258D4A" modified="2016-09-07" version="1">MRKIRFVILTFIIIVIIICSNALYSINNYADPIVAEDDTIDTELQEELDLDELYTFDYDYKKDYIRYCTEYAILYSRADYLTEDELIEFAKKIDNGIIAIENYLGINLNSDHYINSRVFVSIDGSMDDPEFNNENINIEHTSLISVDNVRENTSSYIHELTHIIAWDCSSLWIKEGLAVYLNDKLNGDPTYPNNGCDIDKLSLEFYNSGTLESLTAFDLVGENGVPNYIDYNSEPIFYIYSASFVKYLEYSIGKDNLIKIYKSLNTKEALKDITGKDINILKNDWINSITTVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSZ4</accession>
    <name>A0A174DSZ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF3284)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264771.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27000">
        <property type="protein sequence ID" value="CUO27000"/>
        <property type="gene ID" value="ERS852471_01243"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021701">
        <property type="entry name" value="DUF3284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11687">
        <property type="entry name" value="DUF3284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="152" mass="17595" checksum="0C27A9387BDED253" modified="2016-09-07" version="1">MSKFTVSTVIAYPLEEVFDNFIQLAKEPFNKFNEENPIGAKSKRVARKTKSGDIYMETSVTDYIKNEVYETRTMFLSSKYTGRYEFKDAGDDCTEIILTESQDLYGIMNKIGFVFQSLTAKKKIKKKLDNTINALEDKIIKERNKSENKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVZ5</accession>
    <name>A0A174DVZ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">cobU</name>
        <name evidence="18" type="ORF">ERS852471_01300</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264877.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29663">
        <property type="protein sequence ID" value="CUO29663"/>
        <property type="gene ID" value="ERS852471_01300"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903913at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO29663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="182" mass="21078" checksum="A82106D500B6A9DD" modified="2016-09-07" version="1">MSKIILVTGGSRSGKSSYGESLLKEKDDVAYIATSIIYDEEMKERVKRHKESRNRLWSTIEDYRELYNRVADIKEKYIMLECIGTMITNLIFDKYTNVDNLSKDEINVLEKEIVNEVLKLLEQIRRKDKDAVIITNEVGFSLVSEYKLGRIFTDILGRVNQILAKESDEVYLVACGLPMRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXS2</accession>
    <name>A0A174DXS2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron compound ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">btuF</name>
        <name evidence="3" type="ORF">ERS852471_01307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264889.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30007">
        <property type="protein sequence ID" value="CUO30007"/>
        <property type="gene ID" value="ERS852471_01307"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020309" evidence="1">
        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="34193" checksum="B209988A6EF1620D" modified="2016-09-07" version="1">MKKTFKSIIMMLAILMLALGLVSCGEKNTIEDNTSNAQESVTTYPLTITDTNGNEVIIEKEPETVISLGPNVTEMVYSLDKGDKLVGRTKYCDYPEQALEVQEVGTLTKPNLELIAEIKPDLVVASTHFTDEAKAKLDELGIPTIVLYSEDSFEGVYNSIETLGKILNASPKAEEVVAGMKEKVAEVTKKVEGLEAPSMYYVVGFGEKDSTAGGNTFIGEMIRMANGENIADDSEGWGYSKEKLAEKNPSIIVLAGDNDTKATFESTDFYKDLEAVKNGKVYEIDQNLLNRQGPRLADGLEALAKILHPEAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9E0</accession>
    <name>A0A174E9E0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purB</name>
        <name evidence="12" type="ORF">ERS852471_01381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265027.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34263">
        <property type="protein sequence ID" value="CUO34263"/>
        <property type="gene ID" value="ERS852471_01381"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="369"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="476" mass="54193" checksum="BAC17249969127A7" modified="2016-09-07" version="1">MRNVYDTPLNTRYASKEMSYIFSDDMKFSTWRKLWVALAEGEKELGLDITEEQLEELRANINNINYDEAIKKEKEVRHDVMSHVYAYGLQCPNAKGIIHLGATSCYVGDNTDIIILRDALELIKNKIVTVLDRLSKFAMEYKGMPTLGFTHFQPAQLTTVGKRATLWMQDLVMDIENIEFLLSTLKLRGVKGTTGTQASFMTLFNGDEEKVKALDKIVAKKMGFEKSYGVTGQTYPRKLDSIVLNTLSEVAQSAYKFSNDLRLLQSMKEMEEPFEKNQIGSSAMAYKRNPMRSERIGALARYVIVDSLNPAITAATQWFERTLDDSANKRIAVAEAFLALDGVLNLYINISENMVVYDKVIRAHVDNELPFMATENIMMEAVKRGGDRQELHERIRIHSMEAAKRVKGEGLDNDLIKRIIADDSFKLTEEEILNIIDPKLFTGRAESQVVEFIDEYVNPIIDRYKNAVDIKSEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAI3</accession>
    <name>A0A174EAI3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MazG family protein</fullName>
            <ecNumber evidence="4">3.6.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mazG</name>
        <name evidence="4" type="ORF">ERS852471_01399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265047.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34842">
        <property type="protein sequence ID" value="CUO34842"/>
        <property type="gene ID" value="ERS852471_01399"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047693">
        <property type="term" value="F:ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11723">
        <property type="entry name" value="YabN_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024180">
        <property type="entry name" value="Tetrapyrrole_Mease/MazG_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035013">
        <property type="entry name" value="YabN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002845">
        <property type="entry name" value="Ttrprl_mtas_MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="3">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="3">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="482" mass="55495" checksum="07728490C7A189FE" modified="2016-09-07" version="1">MIKIVGLGPGAPEALTIGAVKTLEESNNLYFRTEKHPTVDYLRDRLNGFKTCDNYYEEGNSFDEVYQNIANDIIEEYRKTKELVYAVPGHPLVAERSVLNIIDLCEKNNIEYSILPAVSFVDAMMDRLKIDPIEGLKIIDAFDIKNQILDKRIGTIITQVYNGLIASEVKLELLEHYNDDTEIIYVRAAGIEGQESIRKIPLYELDMQEDIDYLTSVYIPKDLNNKKDFYDFLEIIETLRGENGCPWDREQTHESIKNNLLEECYEVIEAIDKDDIDSLIEELGDILLHVVFHATIGKEDGYFNINDIIESASKKMIYRHPHVFKDENLETSEEVVANWEELKKKEKEYNTISEEIEGIAKTLPALIKAHKVQKKVSKVGFDFEDVNEAATKVEEELKEVLNVYKSNNREKIINEVGDLLFACVNVSRMLSVDEEEALNTSIKKFSKRFSYIEKNILDSGKNIDDVSLDDMNKLWEEAKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBS3</accession>
    <name>A0A174EBS3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">srrA_1</name>
        <name evidence="11" type="ORF">ERS852471_01407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265063.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35234">
        <property type="protein sequence ID" value="CUO35234"/>
        <property type="gene ID" value="ERS852471_01407"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="25995" checksum="C5D8128DCA12A522" modified="2016-09-07" version="1">MDDKFGKVLIVDDDTHINELIDMYLKSSGYETRQCFNGIDACNIVNEQNIGLVILDIMLPGKDGMEVLKYIRKTSNIPVIMLTAKGEVFDKVLALELGADDYIVKPFDPKELMARVKAVSRRYTTPTTNDDLLKFNGLTIDIGAYEVVYKGNNVKLAPKELELLHFMASNPNKVFTREQLMYEVWGYDYPGDSRTVDVHIKRLREKIKGGEGWEVQTVWGVGYKFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFL2</accession>
    <name>A0A174EFL2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="13">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">metG</name>
        <name evidence="17" type="ORF">ERS852471_01438</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="13"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265121.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36702">
        <property type="protein sequence ID" value="CUO36702"/>
        <property type="gene ID" value="ERS852471_01438"/>
    </dbReference>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 13 14" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="549"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="13">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO36702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="650" mass="73650" checksum="65AFA1A7A35FAA0F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELX3</accession>
    <name>A0A174ELX3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppC_2</name>
        <name evidence="7" type="ORF">ERS852471_01460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265156.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37588">
        <property type="protein sequence ID" value="CUO37588"/>
        <property type="gene ID" value="ERS852471_01460"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="127"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO37588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="338" mass="37589" checksum="27E47D076CD56B74" modified="2016-09-07" version="1">MLTSEEIKNTTQANQEEQDNFEQNQIILTPGQLIMKRFFRNKLAILGLCIILAISLFSFIGPIFSPYGEYEIFYINQTTGEEIRMTETEKIKEKNVGVNVKAPMSAAHPLGTDADGRDVLTRLMYGGRISLIFSIVVTIIEMALGVTLGGIAGYYGGKIDMIIMRLVDIFYCIPFFPLMLVTASLMSAFGVKPQMKIYFLMLIMGVFNWSGVARMVRGQILSIREMDYMQAAEACGLSATRKIFKHLIPNVTPVIIVMATMDLGGFILSESALSFLGVGLAFPYASLGNMVNAVNSSIIMKNYLNIWLPPGLLILFIVMAFNFIGDGLRDAFDPKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENI1</accession>
    <name>A0A174ENI1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proB</name>
        <name evidence="9" type="ORF">ERS852471_01484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265200.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38807">
        <property type="protein sequence ID" value="CUO38807"/>
        <property type="gene ID" value="ERS852471_01484"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO38807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="29164" checksum="2F4BFBCAAA6303DB" modified="2016-09-07" version="1">MEYRNELKNCNRIVVKVGTSTLTYDNGNINLTRIEKLTRVISDLMNSGKEVILVTSGAVGVGVNKLKLKEKPKTIKEKQAAAAVGQCELMHIYSKFFGEYSHVVGQVLLTRDVIEDDHVRENVVNTFETLIENKIIPIVNENDTVAIDEIENIVRFGDNDNLSAIVAGLVSADLLIILSDIDGFYDSDPRKNPNSKLIKVVECITPELEACAGGAGSSLGTGGMATKLTAAKTATSFGVHMILANGNEPTILLDIMNGNEIGTLFLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQC2</accession>
    <name>A0A174EQC2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SanA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265194.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38679">
        <property type="protein sequence ID" value="CUO38679"/>
        <property type="gene ID" value="ERS852471_01481"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="45"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO38679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="207" mass="23917" checksum="81F59CE746AECAAD" modified="2016-09-07" version="1">MEYILWGCLIIVILAALSFITILLIIKNYDKRYILNKNSVIGKCDAVIVLGAGVRADGNPCDLLADRIKTGVEAYLNNDCKAILLTGEEKDETYNEVLVMKRWIKRNYEEIDSNIILLDGLGLCTYDSMYRAKEIFHINSAIISTNRYHLPRAIYIARRLGIKAYGIPSDLRPYDRMKKYKRREVLAQIKDFFLVNIEILKRHKLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGZ6</accession>
    <name>A0A174FGZ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pyk_2</name>
        <name evidence="16" type="ORF">ERS852471_01660</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265542.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49433">
        <property type="protein sequence ID" value="CUO49433"/>
        <property type="gene ID" value="ERS852471_01660"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="14">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="15">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO49433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="472" mass="51689" checksum="59307865989287B8" modified="2016-09-07" version="1">MQRTKMIFTIGPASDNEEILRKFIQIGMSVARLNFSHGTHETHKQKIDLIKKIRKEQNSPTAIMLDIKGPKIRTHNFINDGVELIDGQAFTFICDDEILGDNEKCSISYAALYKDVSIGGSILVDDGLLKFRIDEIKGTHIICTVIVGGVIKNHKGVNVPNVDINLPSITDKDKEDLIFGCKMGVDFVAASFVRKASDIVEVRNILNEHGGEHIQIIGKIESQEGVNNINEILKQADGIMVARGDMGVEIPIERVPIIQKNIIRKCNEAGKIVITATQMLDSMIRNSLPTRAEACDICNAIFDGTDAIMLSGESASGAFPIEAATTMATIAQETEKHIDYVYLNQRLREPAMGDFAEAISYSACRTSNVLNAKAIVAATTSGSTAKLISKYRPKCPIIAITPNEYVLRRLNLTFGIIPLLCQQFETTDEIIAESKKVAKKLSCANDGDNILIAAGFPTTHTGGTNMLKIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIK1</accession>
    <name>A0A174FIK1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">ERS852471_01642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265507.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48469">
        <property type="protein sequence ID" value="CUO48469"/>
        <property type="gene ID" value="ERS852471_01642"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO48469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="103" mass="11343" checksum="E91DA97E00AD4A70" modified="2016-09-07" version="1">MYAVLTTGGKQYKVSEGDVIYVEKLNVEVDSTVELTDVLAVSNGETLKVGTPVVEGAKVVAKVVAQGKAKKVTVFKYKAKKDYRRKNGHRQPYTKLVIEKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FMK3</accession>
    <name>A0A174FMK3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265552.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49720">
        <property type="protein sequence ID" value="CUO49720"/>
        <property type="gene ID" value="ERS852471_01666"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="694"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="901" mass="105617" checksum="CD9A5AD2947E7B07" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTU2</accession>
    <name>A0A174FTU2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265701.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53712">
        <property type="protein sequence ID" value="CUO53712"/>
        <property type="gene ID" value="ERS852471_01750"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="129" mass="14677" checksum="2FE514D7B5BD9AD3" modified="2016-09-07" version="1">MFKRWDFIIIAILMIFSFLPEVIFGFVVGRDFDQTYAEISINGKIEKTIPLTNHTGEEIIDFKSDKGHNTIIINGDKIGIIDADCSDKVCMNPEYISKPGETLVCLPHKFMIEVKGKKNNEDEDIILSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUY6</accession>
    <name>A0A174FUY6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bmrU</name>
        <name evidence="3" type="ORF">ERS852471_01758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265717.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54112">
        <property type="protein sequence ID" value="CUO54112"/>
        <property type="gene ID" value="ERS852471_01758"/>
    </dbReference>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO54112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="295" mass="33043" checksum="B37222E8F056D8F4" modified="2016-09-07" version="1">MKHLFIINPIAGKGNAIRCKEIIEKYFEDKDDYYEIITTERPEEATDVVKNYDYSEECKVYSVGGDGTLNEVINGLIGKNASLGIIPAGSGNDFVRSYLDDSDLSNIIKDTIEGESKEVDVGCINDRYFINISAIGFPADVNLNAKIFKNKHIISGSLAYILGALVSLFKFKSEKIKFIIDGVENTDEMFLVALANGRYYGGGIILAPDAELSDGSLDFYGIKKSNPYKILRYLVAFLTKKDIRKFKDTYYNKCKTLKIISEKEIISNIDGEIIKSNEFNFEIIPKGIKLIVPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7X0</accession>
    <name>A0A174G7X0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265856.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58493">
        <property type="protein sequence ID" value="CUO58493"/>
        <property type="gene ID" value="ERS852471_01829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="17122" checksum="D4CC061EF5ED0A4A" modified="2016-09-07" version="1">MYIKKKRGFALLETLIVISILIVLISLYAKQNFVNLRKSNYYGIKEDILTLNSEEEQLIKVAENKISLDIELMRKLEEEGIEEKIIYTSSNDNNLYIELLDKDIYLIHKKNLERKYRKLEYEVVSEPEKIKLIPTRYITAYTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8F0</accession>
    <name>A0A174G8F0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_01791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205675.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56765">
        <property type="protein sequence ID" value="CUO56765"/>
        <property type="gene ID" value="ERS852471_01791"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO56765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="304" mass="33128" checksum="71CFC55565584B65" modified="2016-09-07" version="1">MVDTSILESFIWSFLGIVVESLPFIIIGSLVSAIIQVFLTEELIRKFIPRVSILGYLGAVLSGILFPICECAIVPITRSLIKKGLPVGIGISFMLAVPIVNPIVIMSTYYAFPNNISIVLLRTLGGALIALLVGLIMGYLYNGKKKEVILKENIMTIRCDCCVSNKFATTKSEKILNLINHGSNEFLNISVYFIIGAFISSIFVALMNNEVIARINTNNLVGVLFMIGLSFILSLCSEADAFVVKGFLNNFGVGAIVGFLIMGPMMDLKNAFLAFGVFKNRFASRLILIITILVTALALLISIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBP5</accession>
    <name>A0A174GBP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265854.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58466">
        <property type="protein sequence ID" value="CUO58466"/>
        <property type="gene ID" value="ERS852471_01828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO58466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="215" mass="25476" checksum="EE6D5DF5E5223829" modified="2016-09-07" version="1">MNTVVIEKNKYVYKGKIYEDNDIESLTSKCGKNIRVVILAENPLIKICEKIDININKDIEKDIQNNLIIDEDTLVDYIIDKKSKKIYIYSIKQRNKVSRILYKAEKMRVEPIQYTLISIIKKRFKYKKTYKALVKINNYLYFIRVQSGILIYSKTMEEREDTLHKLLLEELVGEDLLVDINLKDIIIESISENEVVKEINFINLKEKVEYEISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCG4</accession>
    <name>A0A174GCG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265860.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58559">
        <property type="protein sequence ID" value="CUO58559"/>
        <property type="gene ID" value="ERS852471_01831"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2000858at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="15429" checksum="B0718A1CCD3F78FD" modified="2016-09-07" version="1">MKRKGVTLIETIVSLMILMIVITLFVALVKDYNINLTSRKTKEKLSRITYCIMNELKYNCTKENIISQSNANKIELKNYDNILEDLKCKGLFEVDKGNGITISFSDNSDDSLNVKISIYEDGFTEEREFIKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEH4</accession>
    <name>A0A174GEH4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YtxC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60944">
        <property type="protein sequence ID" value="CUO60944"/>
        <property type="gene ID" value="ERS852471_01887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014199">
        <property type="entry name" value="Spore_YtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08812">
        <property type="entry name" value="YtxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="190" mass="22037" checksum="32F605CEB2E1BBA0" modified="2016-09-07" version="1">MSVLKGDSTVNDDRMIYCINKVNSIIEKIKECLEENEEINIQGFITFRMKELRQGIEDIIEKVVEEYMVEKEYKEFVKLLKYFVDIQESRIDEINIYIQDGGGYIIKDKYGNDIFEEFIKELSECKVDTEANIEDIIISGLITNAPKSVIIHGKDKCNNKEFINTIINVFGERAYCCKGCSECKIVKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GN68</accession>
    <name>A0A174GN68_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3006)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266031.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63411">
        <property type="protein sequence ID" value="CUO63411"/>
        <property type="gene ID" value="ERS852471_01928"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2049264at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="73" mass="8537" checksum="FC94DEA39091B826" modified="2016-09-07" version="1">MGREFYVVDRIEEASLVLESYNGEIIVIEKSNVNKLPNEGDVLIEDNNFFYIDEEETVKRKEKIKNITKGIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSG0</accession>
    <name>A0A174GSG0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Delta-lactam-biosynthetic de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266098.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64901">
        <property type="protein sequence ID" value="CUO64901"/>
        <property type="gene ID" value="ERS852471_01965"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="79"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="355" mass="41699" checksum="E3B2CCC6B1706966" modified="2016-09-07" version="1">MASIDTLKKVAKISKYIGFTSFCYFLNRNRKRTIAYHNVIPDKYWDDSIHLAHSMKESSFRKQINIIKNRFKVDLDIYNPKTLTLTFDDGYLNQYTVASKILDENEITGYFFCAADLINNGKTLDMDMLQYWISYVPYGIYNIEELGLSLNIRNEESRKSEWQKISDKLDEGIKLCNMKNILDNIYKFEELRNYKNHEQMYKIRFSSIDMESINKMKENGHKIGAHTAKHLKLSELSKFELREDINICKYNIEKIYNTKIFCYPYGSQKDISEEVIEELKKNNFTNSFAYSNGPLRGMDYNDYFMPRMFIPDTDDKDLINFVLSGAKHFVSFRKLLPKLGDEACGNESKYSSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVC0</accession>
    <name>A0A174GVC0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266141.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65891">
        <property type="protein sequence ID" value="CUO65891"/>
        <property type="gene ID" value="ERS852471_01990"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1972394at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="85" mass="9872" checksum="D77D3BC97A1C3D45" modified="2016-09-07" version="1">MSSKITKENAEIEKSYDKNRDYLPRARTWYKPEEHELVSKAPDGSETKLPNPLKDPIVCNNIACPEFDYTEGPYLDDELDLNPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GX13</accession>
    <name>A0A174GX13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_01987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266137.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65767">
        <property type="protein sequence ID" value="CUO65767"/>
        <property type="gene ID" value="ERS852471_01987"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="346"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO65767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="574" mass="63736" checksum="BFEF1FB64AE5C58C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GX75</accession>
    <name>A0A174GX75_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266135.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65728">
        <property type="protein sequence ID" value="CUO65728"/>
        <property type="gene ID" value="ERS852471_01986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10047" checksum="3DB6F6595A99AB89" modified="2016-09-07" version="1">MKKWNNPKLMILGVENTKEGVCDCGATIYRTPNNEHYCHRDNLWHRNNCTSLQQGHFQSGSNCPTGGNHEWAGQAHKSNCCCGTKVSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZ35</accession>
    <name>A0A174GZ35_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic binding protein/LacI transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">alsB</name>
        <name evidence="4" type="ORF">ERS852471_02001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266163.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66326">
        <property type="protein sequence ID" value="CUO66326"/>
        <property type="gene ID" value="ERS852471_02001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022949" evidence="2">
        <location>
            <begin position="34"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="50"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO66326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="378" mass="38992" checksum="F50D1A8C2B7EBED4" modified="2016-09-07" version="1">MRKIKKIVSLAVTIALVGSLAGCGSSNSSGSSGTSEGGDTSTSSGDKPYVAVVSKGFQHQFWQVVKKGADQAAADLGVTITFEGPASESDINDQVNMINSALSKKPSALALAALDTQAVSSQLAEAQKQGIPVVGFDSGVPGAPEGQVAANAATDNYNAATIPADKLLEVETIVEKIKGATAASPVAIGVVSQDATSASLIDRTKGFIDRAFEKCEELVGAGNVEVVGHDSYNKKATGEAIVKIVVNVPPTTSATDVQNSAQAVLATENLIAIYGSNQGGVDGILAASNDGSDFNKENGKYKDIVAVGFDSGKGQKTAVEKGWFLGSVTQDPYQIGYQAVALAVKAMNGEKVSDVDTGAKWYDQSNFNDEDINQLLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZ60</accession>
    <name>A0A174GZ60_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266151.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66089">
        <property type="protein sequence ID" value="CUO66089"/>
        <property type="gene ID" value="ERS852471_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="23284" checksum="95BC07602176554F" modified="2016-09-07" version="1">MNLNSKKTQNIIIVVLILALILTFSIDAIQASIDRNESASIKERPPIKNTLKDYVIEKEEDPLYEIEIDTEIESEEEVNDEIIDTSEDYVTPDEGYNDNYEDDYDNTYEEGYNGNINNSSGNGNTGNGNQGSETPAPPIVTPPTDPAPDEPVDIPTEKPQEPEAPKPEEPVIPEVPETPETTPEDVPSDDSESVPNPEDFSDSELNSNSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H448</accession>
    <name>A0A174H448_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein ERS852471_02076</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaaA_2</name>
        <name evidence="2" type="ORF">ERS852471_02076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69792">
        <property type="protein sequence ID" value="CUO69792"/>
        <property type="gene ID" value="ERS852471_02076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="29281" checksum="35C05778EBA60190" modified="2016-09-07" version="1">MTKENISIIISPAKKMNICDDDLSPTSIPCFIDKTQILYDTLKSFSYENLKQLLACNDQIAELNYDRYLHMDLTKGFTPCILSYEGIQYKYMSPNSFSNEEFEYINKHLKILSGFYGVLKPFDGVTPYRLEMQAKLKTNNFKDLYDFWGDNIYKEVRKDSDIILNLASKEYSKTIEKYLTPEDKYITCIFGSLKDSKIKVKATEAKMARGLMVRYLATNNIHNINDIKNFSDLSFKYSEKHSSENEFVFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFD2</accession>
    <name>A0A174HFD2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 14">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hemB_1</name>
        <name evidence="16" type="ORF">ERS852471_02162</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 14"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266470.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73593">
        <property type="protein sequence ID" value="CUO73593"/>
        <property type="gene ID" value="ERS852471_02162"/>
    </dbReference>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO73593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="36087" checksum="E156C898E724DF55" modified="2016-09-07" version="1">MIKRGRRIRETAAIRAMVRENILTANDFIYPIFVVEGENIKEEIKSMEGNYHWSIDRLEEVINEVINCGVKGIILFGIPDTKDECGSSAFDSNGIVQRAIKKIREISKDLYIITDVCMCQYTIHGHCGILDGHRIDNDATLEKLGQIALSHAKAGADMVAPSDMMDGRIGFIRNVLDNNGFTHVAIMSYAAKYASAFYGPFREAAHSAPQFGDRKSYQMDPANGREALREINMDIEEGADIIMVKPALSYLDIVRKAKDIVDIPICVYNVSGEYSMIKAAAKAGLMNEKATALEMLLSMKRAGADIIITYYALEASKWLKETQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFJ1</accession>
    <name>A0A174HFJ1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
            <ecNumber evidence="2">2.7.7.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbF</name>
        <name evidence="2" type="ORF">ERS852471_02123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.33" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266393.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72157">
        <property type="protein sequence ID" value="CUO72157"/>
        <property type="gene ID" value="ERS852471_02123"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="29337" checksum="67DC61BDAB96EAA9" modified="2016-09-07" version="1">MKVVILAGGKGIRMSQLTVDTPKPLCEVGGMPILWHIMKMYQYYKFNDFILLLGYKGEKIKEYFMDYYWKTNSFKLDMNSGDIKVYSDPEDFKITFVDTGIDTMTGGRIKRAKEYIGNETFMLTYGDGLADIDIEELLKFHKKQGRIATVTGIYKKSQYGILTVGDGVAKSFEEKKNTEEIINGGFFVFEPEIFNYLENDSTCVLEQSPLKKLVADNQLAVYMHNGFWTAMDTLSDINNVNIMWNEGRRLWKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNJ5</accession>
    <name>A0A174HNJ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV fimbrial assembly protein PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">epsE</name>
        <name evidence="3" type="ORF">ERS852471_02227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266567.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75791">
        <property type="protein sequence ID" value="CUO75791"/>
        <property type="gene ID" value="ERS852471_02227"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="559" mass="62578" checksum="781170A9BF1702C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQT2</accession>
    <name>A0A174HQT2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="8">IMP dehydrogenase</shortName>
            <shortName evidence="8">IMPD</shortName>
            <shortName evidence="8">IMPDH</shortName>
            <ecNumber evidence="8 15">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">guaB_2</name>
        <name evidence="8" type="synonym">guaB</name>
        <name evidence="17" type="ORF">ERS852471_02217</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 14">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8 15"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266549.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75468">
        <property type="protein sequence ID" value="CUO75468"/>
        <property type="gene ID" value="ERS852471_02217"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 8 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO75468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="484" mass="52228" checksum="76F985362B724B10" modified="2016-09-07" version="1">MAKILKTAYTFDDVLLVPNKSEVLPNQVSLKTKLTKTITLNIPLMSASMDTVTESKMAIAMAREGGIGIIHKNMPIEEQAREVDRVKRQENGVITDPIFLNENHTVREALDLMARYRISGVPVTRGTQLVGIITNRDIVFETNYDRLVSEVMTKSPLVTAPEGTTLDQALEILKTHKIEKLPLVDNENNLKGLITIKDIEKVRAFPNAAKDSRGRLLCGASVGITADMMDRVDALVKAQVDVITLDTAHGHSKGVIEGVKKIKAKYPELQIIAGNIATAEATKDLIEAGADCVKVGIGPGSICTTRIVAGVGVPQLTAVMDCVEEAVKYGIPVIADGGLKYSGDIVKALAAGASVCMMGSMLAGCEESPGETEIYQGRQYKVYRGMGSLGAMEKGSSDRYFQNGTKKFVPEGIEGRVAYKGYVADTLYQLMGGIRSGMGYLGAPTLVDLYENATFVIQTSSGIRESHPHDVKITKEAPNYSVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTA7</accession>
    <name>A0A174HTA7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase, P-type (Transporting), HAD superfamily, subfamily IC</fullName>
            <ecNumber evidence="9">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266624.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76816">
        <property type="protein sequence ID" value="CUO76816"/>
        <property type="gene ID" value="ERS852471_02255"/>
    </dbReference>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="888" mass="96873" checksum="E4C72B41A671C7CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I049</accession>
    <name>A0A174I049_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydaF</name>
        <name evidence="2" type="ORF">ERS852471_02289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266677.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78455">
        <property type="protein sequence ID" value="CUO78455"/>
        <property type="gene ID" value="ERS852471_02289"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1501005at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO78455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="35945" checksum="5434C9A2ED2E0330" modified="2016-09-07" version="1">MENQKEIYIELVNGTLNDYVIKDKDKILIGRFTIVELDKENKKCNVKLKFYRDKNYDLLKDAIKSILKAIFKDNDIFKANFIVNENTNLSPFLDMGFTLEAIFTDNLFIKGNFQDELGLGINRNEYINCSRNTIVELKGRNIKIRNFTPDDAEELTEYYIRNKDHLKNFEPTRDSSFYTYEVQKEILLESYRQLMTGAGSDLGIYKDDKLIGKIKISNVVYGVFKNGIVGYSIDKEYEGKGYMKEAVNLALEYAKNYLDLHRLEASILTDNVRSKGVLLSCGFEEVGLNKNYLYINGSWRDHITFYKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4N1</accession>
    <name>A0A174I4N1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, M23/M37 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nlpD</name>
        <name evidence="3" type="ORF">ERS852471_02334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266753.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80049">
        <property type="protein sequence ID" value="CUO80049"/>
        <property type="gene ID" value="ERS852471_02334"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
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        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="2">
        <location>
            <begin position="179"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO80049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="43749" checksum="C32FE6CC2E79174D" modified="2016-09-07" version="1">MYSQKKDEKCVIRKTTLSLIVLTILLFLISEITNGYSIHGNRKTVQCINVINDSNEIPQGVYLANSSDISNNYNDIVNLESKNLNANIDNINRNVNGFAITVDNNIFGYVLSAQEKDEIIESVCESYIRELGVNVEDISYMKINGNIKVTPTELKLCQLSNSSEISKDIYEASIINKSLLDLELSLRTFQEENIESPVIVEEDNSIYMGEEVIVQGSDGTKEVYKEVVYDGLTKVEENILNENVLVEPIATVVYRGSKNPYYDGVSFLERPVDGGYISSYYGEDRVNSYHKGLDIAENLGEDIIASFEGKVIYAGYNDGGYGNLVIVQHSDDMKTYYAHLSEIYVSLNQEVKKGEIIGAVGSTGYSTGPHLHFELRINETPVNPLNYIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IE83</accession>
    <name>A0A174IE83_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pnbA</name>
        <name evidence="3" type="ORF">ERS852471_02414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266884.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9clot-a0a174ie83">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83420">
        <property type="protein sequence ID" value="CUO83420"/>
        <property type="gene ID" value="ERS852471_02414"/>
    </dbReference>
    <dbReference type="OrthoDB" id="489066at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO83420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="523" mass="58447" checksum="0D3AAAE44270AFB0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IG46</accession>
    <name>A0A174IG46_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266966.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85421">
        <property type="protein sequence ID" value="CUO85421"/>
        <property type="gene ID" value="ERS852471_02459"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971345at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO85421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="19299" checksum="EE4D412F3B4D10FB" modified="2016-09-07" version="1">MHREVVHGRKIPAIMISLLAITIALYAVEIAEIVIGKTFQVYRVIEVLLLIMIVFVLFKEFRRCSLSYKYSIIADKLIINKLNCKGDNILESIRMQDIVFIGKKVEIPKKLSKIKSHGNYLSSITTSRKCYCVYKRNGQLLKFSFEPSERLLKRVYDKVNILQGEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IIC8</accession>
    <name>A0A174IIC8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rpsS</name>
        <name evidence="8" type="ORF">ERS852471_02497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117028.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87003">
        <property type="protein sequence ID" value="CUO87003"/>
        <property type="gene ID" value="ERS852471_02497"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO87003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="94" mass="10793" checksum="A2C76FCBA508DFBD" modified="2016-09-07" version="1">MSRSIKKGPFVHEGLLKKIEEMNANGEKKVVKTWSRSSTIFPQMIGHTIAVHDGRKHVPVYVSEDMVGHKLGEFVLTRTYKGHDYDEKASRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ITM5</accession>
    <name>A0A174ITM5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">truA_2</name>
        <name evidence="4" type="synonym">truA</name>
        <name evidence="9" type="ORF">ERS852471_02526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88249">
        <property type="protein sequence ID" value="CUO88249"/>
        <property type="gene ID" value="ERS852471_02526"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO88249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="244" mass="27596" checksum="A5B0179A21A505EC" modified="2016-09-07" version="1">MNNIKLTIEYDGTNYYGWQRQKDKISIQEAIEQAIASITKENSEVIGSSRTDAGVHAKGFVANFKTNSSVPPNRFREALNTKLPDDIVIIKSEAVNDEFHARYNAKGKTYEYNLLNTEAPSALLRNYSYHPKYDLNVEAMKEAAKYFIGTHDFIAFRSQGSSVKGTVRTIFDLKVEEKDEIIKISVTGDGFLYNMVRIIVGTLIEVGRGKTKSEDIKEIILKKDRKLAGFCVPAKGLFLKEVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J046</accession>
    <name>A0A174J046_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267176.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90968">
        <property type="protein sequence ID" value="CUO90968"/>
        <property type="gene ID" value="ERS852471_02583"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO90968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="253" mass="28121" checksum="4D996774FF17C763" modified="2016-09-07" version="1">MRSKTFAKRNIKEVLRDPLSYIFCLGFPIIMLIIMTFVNNSIPKEANMKIFNIEYLAPGIAVFGLTFIMLFTCLQVSKDRASAFLIRLYASPMKSRDFIGGYMMPFFIIALAQSVITFLVAAIIGVFSGYTFNILNVVVSIITLIPSVILFIGFGMLFGTLFGEKSAPPLTSIIITISSILGGIWMDIESLNSGMKTICNILPFYHGVEAARMAIVGEFDKIIIPLIVVTIYAVVIYIISVFVFKAKMKNDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J1D5</accession>
    <name>A0A174J1D5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transthyretin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91398">
        <property type="protein sequence ID" value="CUO91398"/>
        <property type="gene ID" value="ERS852471_02593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO91398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="21841" checksum="8DA6ECCBA0A8AD63" modified="2016-09-07" version="1">MKIRIDDDYDKDDLEKFNIIANDYKNRNDEQQDDILKGNVIEATFQEVEMDNKDCSKDYSKEYYKDYENYYMNYEERENNDEDEEGLGKITVISRLANKNRTLISSAKINLYVLNGVSPKLVETKYTDKNGQVVFENLKRGSYRVIAIVDRKYFEKPTYSPWNEVTIDKSTIETTIEVMNKIKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JFY3</accession>
    <name>A0A174JFY3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin-nitrite reductase</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sir_2</name>
        <name evidence="5" type="ORF">ERS852471_02717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267419.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97126">
        <property type="protein sequence ID" value="CUO97126"/>
        <property type="gene ID" value="ERS852471_02717"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="118"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="301"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="379"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO97126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="516" mass="58757" checksum="5349D31AB583CF40" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JH40</accession>
    <name>A0A174JH40_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hrcA</name>
        <name evidence="7" type="ORF">ERS852471_02713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267411.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96948">
        <property type="protein sequence ID" value="CUO96948"/>
        <property type="gene ID" value="ERS852471_02713"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="106"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO96948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="38500" checksum="2911518D8B83A4DB" modified="2016-09-07" version="1">MAIDERKIKILQAIINDYIMTGEPVGSRTIAKKYNLGVGSATIRNEMADLEEMGYLEQPHTSSGRIPSSKGYRLYVDRLMEKAQLSKEEELKIKEYIINSAMYEVDKILKEACVLLSELTNLTCIVQTPSMKRSYIKSIQLIKIDESNLISVIVTDSGVIKNHRIKISNMPPSDKLARINDVLNSKLKNLTIEAINLEVINEVKKELAGFDDLFNAILPALYESLNSSDKEELVVEGTTNLFNYPEYNDIEKAKEMIQLISNKDCVIELLEPDGDITVRIGDENYIPEAKECSVITAEYTLGGRAIGSIGLIGPRRINYSKVLSIMAQVMKELNKSLKNQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JKL6</accession>
    <name>A0A174JKL6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recO</name>
        <name evidence="9" type="ORF">ERS852471_02732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97715">
        <property type="protein sequence ID" value="CUO97715"/>
        <property type="gene ID" value="ERS852471_02732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO97715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="28099" checksum="3E6F7D1E455EDB85" modified="2016-09-07" version="1">MALLNTKGVVLKSQDYRENDKLIWIYTEAAGKVTAIARGSKKSKSKFLSMTLPLCFADYSLFQGKNLYNLQEGKIINSFQGLLDNLDKLTYSSYVCELIDICVEDGEQNFNLFKDFITCLYLLNTDALDYELLIRSFELRVLKATGYGLVFDNCSICKKPINSSTYISLNNFGGVCDECNKVGGIYISRAAYSALRFLNNTPMDKVYRLNLTDEVKKQIEKVTTYIIYSNYSKRPKSLEMLNYIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JP56</accession>
    <name>A0A174JP56_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hybrid cluster protein-associated redox disulfide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO98829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267484.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98829">
        <property type="protein sequence ID" value="CUO98829"/>
        <property type="gene ID" value="ERS852471_02753"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1961381at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO98829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="6621" checksum="DABD24AC8D19BB55" modified="2016-09-07" version="1">MIKKVDIIADVLKKNKNAEEILRSFGMGCLGCPSATMESLEDACEIHGIDIDEVLKKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JRE1</accession>
    <name>A0A174JRE1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">murB</name>
        <name evidence="18" type="ORF">ERS852471_02822</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267614.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02364">
        <property type="protein sequence ID" value="CUP02364"/>
        <property type="gene ID" value="ERS852471_02822"/>
    </dbReference>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUP02364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="33289" checksum="F3B9B557C81FC2B2" modified="2016-09-07" version="1">MNKYNNYVDLFTSFYSDEDVKINEKLSQYVNFKVGGPADILVTPRNKEQIIRTVNICKENNIPFYVIGNGSNLLVKDGGFRGVVMSLTKVNNITVDGERIEAECGAMLKQVSDKAVENSLTGFEFACGIPGTVGGAVFMNAGAYNGEMSQVIESADVINENGEIITLNNEELDLGYRSSIVMKKGYVVLSAVFKLEKGIVKSIKDLVADLTNKRESKQPLEYPSAGSTFKRPEGYFAGKLIQDAGLKGYSIGGAAISEKHSGFVINKGGATAKDILDLIHHIQDEVKKQFGVELHTEVRIIGEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JYA6</accession>
    <name>A0A174JYA6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">uvrA</name>
        <name evidence="17" type="ORF">ERS852471_02827</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267623.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02568">
        <property type="protein sequence ID" value="CUP02568"/>
        <property type="gene ID" value="ERS852471_02827"/>
    </dbReference>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="UvrA_inter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="600"/>
            <end position="937"/>
        </location>
    </feature>
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            <begin position="252"/>
            <end position="279"/>
        </location>
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        <location>
            <begin position="740"/>
            <end position="766"/>
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        <location>
            <begin position="32"/>
            <end position="39"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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    <feature type="binding site" evidence="14 15">
        <location>
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            <end position="648"/>
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        <ligand>
            <name>ATP</name>
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        </source>
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    <sequence length="941" mass="104701" checksum="AA6662B4C28C5D09" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K0N8</accession>
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        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Clostridium disporicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUP05562.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="518" mass="59107" checksum="E281045CDDEF4A90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K247</accession>
    <name>A0A174K247_9CLOT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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    </dbReference>
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        <property type="gene ID" value="ERS852471_02914"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
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    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
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            <end position="235"/>
        </location>
    </feature>
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        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
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            <begin position="97"/>
            <end position="293"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP06144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="308" mass="33954" checksum="597BB8E2C6F05219" modified="2016-09-07" version="1">MLETNNVKQKSSLKKKKKSNLYLSDKQPLTLGGKIALGISYVFLIGWALAVIWPILQIIISSFNGEQGKRLNLNAGFSFSLKHFQHLFENTMYLKWMGNTIFISVVTAILVVLIVSFTGYAYSRYRFKGKKVSLMTIMLIQTIPQFVGITAYFTMYSIASDMVPAFTRQMMLILIYAGTGIAGNTIILKGYLDSISTELDDAAKIDGCSSMKIYRLIIMPIARPMLAIIALWSFIGPFMDVLLSKVLLTTPADYTLSVGLYTLVNDERTINQPAFAAGALLAAVPIVILFIALQKQLVSGLSNGATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5J3</accession>
    <name>A0A174K5J3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267722.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05038">
        <property type="protein sequence ID" value="CUP05038"/>
        <property type="gene ID" value="ERS852471_02881"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2132621at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP05038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="17776" checksum="70D9F733A34328A1" modified="2016-09-07" version="1">MIRINFKNFKGFNDSKVTDANGKEIINFEKVKALPTRACYSIVNANHEKIGRIEKRRYNFGLVDLPQIIISVNNDKIEIQKDMKELKEFYEIKGSNFSISGNWDGPQFNISKNEKVLASVNVQKEESGGTYLVDIIDKANENQVLCILFALSWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K792</accession>
    <name>A0A174K792_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dusB</name>
        <name evidence="9" type="ORF">ERS852471_02882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267724.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05069">
        <property type="protein sequence ID" value="CUP05069"/>
        <property type="gene ID" value="ERS852471_02882"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1320183at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="PTHR42907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="8">
        <location>
            <begin position="15"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="38743" checksum="D56C3586A7440C3A" modified="2016-09-07" version="1">MEKYTSNIPTPKISIAPMVDKSHRHFRYFCRIMNKEALLYTEMVTAQAIINGDLDKILYFRKEEGPVALQIAASNAEDAYKALKLAEGFNYTEINLNCGCPSDRVSGNLMGAALMSDKNLVYEILSAMKEATNKPVTIKHRIGIDGTGVITDNNSKIIMEGYEDLLDFLDTVSKAKPDRYTVHARSAILKGLSPKDNREIPPLDYEMVYKLKNDFNYLNIEINGGFKTLDSIKDALTKIDGVMIGRASYEDCYLLANLNKLNYENIKPISRGDIIKSYIPYVEEELERGSNVHSLAAPLQSLFQGQPGSRKFKQLISSSNVKRETLVPLLNNILEVMPQDILWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7D4</accession>
    <name>A0A174K7D4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysG</name>
        <name evidence="9" type="ORF">ERS852471_02951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267844.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08034">
        <property type="protein sequence ID" value="CUP08034"/>
        <property type="gene ID" value="ERS852471_02951"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="8">
        <location>
            <begin position="268"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP08034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="498" mass="54897" checksum="2BCAFD54B005BB46" modified="2016-09-07" version="1">MNTGKVWLVGAGPSDEGLFTLKGKRVLEQADVVVYDQLVGDGIMSMIPANAECIDVGKHAGNHKVVQERINEILLEEAQKGKRVVRLKGGDPFLFGRGGEELELLCEHNIPFEIVPGITSAISVPAYAGIPVTHRDFTSSLHIITGHKKKGCNDPIDYKSLVALGDVTLVFLMSVGALPDISKGLIEAGMDKNTPAAILEKGTRYNQRKVVATIETLPEEARKNDVGTPGIIIVGKVCSLSEQFSWAEKRPLGGKRIIITRPRRKSSKLKEMLYDLGAEVVEVPSFETVAINNNEVLDEAINNIKDYNWVAFTSEAAVEIFFNELRDTKIDIRNLINVKFAVVGPATKKAVESRGIFVEYMPEEYYGEAMAKGLSERISVDDKVMVCVPKEVDTELYKNLKSYEKQIDVVPLYDIVYEKNKDIKVNDEDYVVFTSASSVKGFVNSIDDLDYNSINSICIGKKTAEEASSYGMKVSVSKEATIESLVECVIECSKRGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9Z5</accession>
    <name>A0A174K9Z5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase BglA</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bglA2_2</name>
        <name evidence="6" type="ORF">ERS852471_02924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP06927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267799.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06927">
        <property type="protein sequence ID" value="CUP06927"/>
        <property type="gene ID" value="ERS852471_02924"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP06927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="54125" checksum="53EE5DEEF5399D4A" modified="2016-09-07" version="1">MDKNFLWGGAVAAHQLEGGYNAGGKGLSIADVMTVGGNGIHRRITDGVVEGEIYPNHEAIDFYHHYKEDVALFAEMGFKCFRTSISWARIFPNGDELEPNEEGLKFYDDLFDELLKNGIKPVITLSHFEMPYNLVKQYGGFRNRKCIDFFVRFAKVCFERYKDKVEYWMTFNEINNQTAVENEFGIYTCSGVRFKEDDNREELMYQVVHHEFIASALAVAEGKKINPNFKIGCMLACVPVYPYSCNPDDVMQAVEQMHQRYMFTDVMVRGYYPSYTKKFWEKNNLNIVMEPGDDEILRNGCVDYIGFSYYMSATTKTGEDTIMAGVKGAVQNPYIKSSDWGWPIDPVGLRYSLNVLYERYQVPLFIVENGFGAYDKLSEDGKYHDDYRVEYLRKHIEQLKKAVDEDGVDVIGYTVWGCIDVVSYGTGEMEKRYGFIHVDKNNKGEGTLRRSKKESFNWYKNVIASNGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KG22</accession>
    <name>A0A174KG22_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhhJ</name>
        <name evidence="8" type="ORF">ERS852471_02967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267874.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08728">
        <property type="protein sequence ID" value="CUP08728"/>
        <property type="gene ID" value="ERS852471_02967"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP08728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="247" mass="27183" checksum="241D8CE2300B905D" modified="2016-09-07" version="1">MKSFITMLKTELKLSLRGMDMFIFAICMPIVVLVAIGIIYGSKPAFEGANYTFLEQSFGAITSIAICAGGVMGLPLVVSDYRSKHILKRFKVTPVNPIVILLVQVTIYALYSLVSMISLFLVAKLFFKFNIQGSILNFILGWLLVMISMFSIGIMVGGISKDSKIAGVIASVLYFPMLIFSGATIPYEVMPNIMKNIVDVFPLTQGIKILKSAILGQSVENIIIPIFIMLIIATICSIVAIKCFKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KHG4</accession>
    <name>A0A174KHG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267994.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11372">
        <property type="protein sequence ID" value="CUP11372"/>
        <property type="gene ID" value="ERS852471_03026"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1652708at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="28912" checksum="7208062CA6DE4789" modified="2016-09-07" version="1">MRVLNKFIKIVCGILIFILLLTLGFYIAQKIRVFGKTSTDIINPQTQTFEEIIELSDEITMEKKLFSFRKHYYILSDGVLIGEVKGKFFPIFGDTLQLKDIHGNLIKKESQIKRLGLTQVKLFNISINRLAKVEDANGDTTGYIGEEKQRDFWRLKRVQYFYDENHNKQGRAIPDAILFCKDYKIYDNENNVDYVIDGRFFSPTHRYNIEIRDKSDIDVEEAIFYTIIENSIISSKMKESSSSSNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKV0</accession>
    <name>A0A174KKV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267963.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10817">
        <property type="protein sequence ID" value="CUP10817"/>
        <property type="gene ID" value="ERS852471_03010"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053299at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPA_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="58" mass="6329" checksum="1E39384D6A3AA6F9" modified="2016-09-07" version="1">MSAKEQVLNLLKENSEAMKAGEIAAALSIDKKEVDKAIKELKTDGSITSPKRCFYTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KP31</accession>
    <name>A0A174KP31_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268033.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12581">
        <property type="protein sequence ID" value="CUP12581"/>
        <property type="gene ID" value="ERS852471_03044"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026341" evidence="1">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="66"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="25151" checksum="A316B528EB70EE35" modified="2016-09-07" version="1">MKKYLLVLLLFTSFMVKPVYALEKTEVNNGYVMEESKYSEFDNESERIIKRMEKTMQVLPITENIDYNFINEMIALHTEEIQLSTIIQGYTDNPEVLEYANDLLSAENGELREMRIIKKDLAKDMNKPTKGNEAYVKEFNSLLKGRFNNLYAYERYEDPAKNYLNIMNLNNEADIALANTYLKYSDNEVVKKVAENIINVKKEQISKAKELLAGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXL4</accession>
    <name>A0A174KXL4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDGSH-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268178.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16802">
        <property type="protein sequence ID" value="CUP16802"/>
        <property type="gene ID" value="ERS852471_03126"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667004at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="147"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP16802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="39568" checksum="DE2A3DF8F4DF57E1" modified="2016-09-07" version="1">MATLSNIKSDITSLSEYQLRELFNYIGEMLTLGSSNVSLNKEFRESRFSKGQCCPHCESTSVVKNGKLNGKQRYVCRSCSKSFNDLTKSALSCTKLPLQTWIEYVKGMVIGLSIRKNAENVGVGVKTSFYMRHKILDCIRAFMGIGDVDGIVEMDETFVAESFKGNHKKSGFKMPRPARKRGKQVKKRGISNEQVCIATAIDRNGNIILEPLCKGRVTYNALERLYEGRIDSNSIICTDSHKSYIQFAKDLELDHKKIARGHYKNDIYHINHVNSLHSNLKIWMYRFKGVSTKFLSNYMSWYKWLQSFSTDKEVIKTKNMLIHSVIPFVDTKIEGYKERKYNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KYK2</accession>
    <name>A0A174KYK2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative zinc-dependent protease</fullName>
            <ecNumber evidence="5">3.4.24.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptrA_2</name>
        <name evidence="5" type="ORF">ERS852471_03081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.55" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268103.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14565">
        <property type="protein sequence ID" value="CUP14565"/>
        <property type="gene ID" value="ERS852471_03081"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="171"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="413" mass="47397" checksum="3708C3C5A90FE27D" modified="2016-09-07" version="1">MIKLNFDVKKHLLPNGLEILTIKKDTQISSVNIGIKVGALYEKVSEKGISHFIEHMIFKGTNKRSFQLLNDELEALGGEYNAYTDFTSTVYSISCLEEELKNGIEILADMVTSSIFLQEEIEKERGVILAEIRTSKDSVEDLSFKRANEVAFKKGPLRYDVAGMEKNVKRFNHKDLYTFYKKHYVANNSVITIVSSYEHEEALKMIQDQFGSWNSGEVKLLKVKDEKNINTKEVTVKENIELNTIIYLYTFYDLDKEYELPLRILNHRLGESSNSLLFREIRENRGLAYDIYSHLDVTKHVKTLYIYTAVDEEDIDSAIEAIDETLAGIKMGKIEIGEKDLNIMKKVHKTAVVSTLEDPVELCSYILTQRVEGEDIFEFLDDMDSLNNITKDKIYDVANKVLNNPTIHILKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L024</accession>
    <name>A0A174L024_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268117.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14889">
        <property type="protein sequence ID" value="CUP14889"/>
        <property type="gene ID" value="ERS852471_03088"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP14889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="37229" checksum="998257AAD5B5AE38" modified="2016-09-07" version="1">MKNKLDYLYDNAFTIPFDDSSKLVFISDVHRGDGTYFDSLLPNANIYITALKYYLRNGYTYIEVGDGDELWKNKNFNEIAYTYEEVFKIFNKYKKKDNIYIIYGNHDIIKRNKKFKDIQENALKKIGADYGREFLKFIEDIEFYPGLNMLYTPLNEKFLVTHGNQMDFGNNELWFVSRFLVRYIWKFLFGIAGFRDPSSSAKNKTRRTRVDLELQNWARDNGKMLLCGHTHNSRFPGEFEPPYFNDGCCILPYAMTSIEVEGGDIALIKWSVDAQDSGVLWVKRKIIGGPRKISTFLLWAKEERLRVNRENNKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L419</accession>
    <name>A0A174L419_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">dtd</name>
        <name evidence="2" type="ORF">ERS852471_03116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP16140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268162.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16140">
        <property type="protein sequence ID" value="CUP16140"/>
        <property type="gene ID" value="ERS852471_03116"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP16140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="16721" checksum="B94F4931DA25B464" modified="2016-09-07" version="1">MRAVVQRVKKSSVKVDEKIVGSIQYGLNVLIGINVDDTLDDLKYIVDKVINLRIFHDDNDKMNLSVKDIDGEILAISQFTLYGDCRKGRRPNFMNALGGSEAEVLYNKFIEMLKETGIKVETGIFGAHMDVEIQNDGPVTILLDSKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJ39</accession>
    <name>A0A174LJ39_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ORF">ERS852471_03235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268367.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22577">
        <property type="protein sequence ID" value="CUP22577"/>
        <property type="gene ID" value="ERS852471_03235"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1974284at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP22577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="76" mass="8576" checksum="32A934E44A696E5C" modified="2016-09-07" version="1">MAIKEGVKTKSKSEKNSIAKFFREIKAEVKRITWPSKDDTKKALIAVGVVVLIYIVLVGGLDYIFSSLFKLIFNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LM69</accession>
    <name>A0A174LM69_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25352">
        <property type="protein sequence ID" value="CUP25352"/>
        <property type="gene ID" value="ERS852471_03279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="52" mass="6276" checksum="9EAF93515615D908" modified="2016-09-07" version="1">MNNREELELRLKELKLKKRELVLANKNTDKIDKDIKNIEIEIELLLENKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LNP6</accession>
    <name>A0A174LNP6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lantibiotic ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_6</name>
        <name evidence="5" type="ORF">ERS852471_03268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268428.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24581">
        <property type="protein sequence ID" value="CUP24581"/>
        <property type="gene ID" value="ERS852471_03268"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP24581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="304" mass="33857" checksum="AA3E774658A713DA" modified="2016-09-07" version="1">MNIIETENLTKQYGTTTVVDNINLHVPKGKIYGLLGRNGAGKTTAMKMMLQLVYPTGGAIRLFGTDYKEHTHSLYGKIGSIIETPGFYSNLTGYENLKIIAKLRGQLSKDSVQEALRVVGLEKETRKVFADYSLGMKQRLGIAAAIMHEPELLILDEPINGLDPIGISEIRSFLSELSHSKGTTILISSHVLNEIEQIADIIGVMHEGRLIEEVNMAELQKRNRRYIEFELSNVEIAAKILENHYQIKDYSIQGNTIKIYDFTHNSGEINKAFVENGLLVTKINIDEENLENYFSGLIGGGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LP21</accession>
    <name>A0A174LP21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268409.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23798">
        <property type="protein sequence ID" value="CUP23798"/>
        <property type="gene ID" value="ERS852471_03257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP23798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="73" mass="8635" checksum="F98A20E232751E7F" modified="2016-09-07" version="1">MSYGPVALDKAYADIVNSQSVLQESYLDEQRHKHNNDFNNHFKNTHRETYWKVCIDYAVKLGLESKKYKLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LZ91</accession>
    <name>A0A174LZ91_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">niaR</name>
        <name evidence="4" type="ORF">ERS852471_03304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000042">
        <property type="protein sequence ID" value="CUP27040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268478.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27040">
        <property type="protein sequence ID" value="CUP27040"/>
        <property type="gene ID" value="ERS852471_03304"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1652220at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035922">
        <property type="entry name" value="3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004173">
        <property type="entry name" value="3H_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026043">
        <property type="entry name" value="NadR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40068">
        <property type="entry name" value="PTHR40068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02829">
        <property type="entry name" value="3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037847">
        <property type="entry name" value="NiaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75500">
        <property type="entry name" value="SSF75500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="3">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="3H" evidence="2">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037847-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP27040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="169" mass="18962" checksum="E4B8FBA882A8A821" modified="2016-09-07" version="1">MIANNRREAIVELLLKEKAPVKGVELATKFDVTRQIIVKDIAILRAKGNNIIATPDGYMFNDDNGSRVRAIIAVNHNKDEMIKELEIVIKYGGIIEDVIVEHPIYGEIKGLLMIKNLNDLNRFKNTFELSDSAPLSSLTNGVHLHTVSVDTKENMELIKKELKENGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LZQ7</accession>
    <name>A0A174LZQ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araC_3</name>
        <name evidence="3" type="ORF">ERS852471_03322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000045">
        <property type="protein sequence ID" value="CUP28147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268506.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28147">
        <property type="protein sequence ID" value="CUP28147"/>
        <property type="gene ID" value="ERS852471_03322"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP28147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="32451" checksum="4AE725D460401782" modified="2016-09-07" version="1">MQILWRKYKKENFDINLDECGIEHGIPGFGYRYKVLKNSVIHYVIRGYGTFKVNDKVYNLKEGDIFILLKGMDVEYMASMDNPWEYCWIGFSGSKADEYLNRTSIIDSHVANCNENSKIPCIILNICEISKNYNPSNSDDILLLNELYSLLYELIGEFPKPFEYKDKEIHKYIQDTINFINSNYMNNITVNEIAEHVNLSRSYLYKMFIKNLKISPQKYLINLRMYKATLLLKNTKLPIGEIANKVGYADSLLFSKTFSKYFSVSPLNYRNNKVNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFD0</accession>
    <name>A0A173XFD0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted Zn-dependent protease (DUF2268)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262716.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50542">
        <property type="protein sequence ID" value="CUN50542"/>
        <property type="gene ID" value="ERS852471_00033"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1459765at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018728">
        <property type="entry name" value="DUF2268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10026">
        <property type="entry name" value="DUF2268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2268" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10800" checksum="60E9429142C6959D" modified="2016-09-07" version="1">MNIKAIRSDDIYRKMMTASKEEKENIYRYELMKPFEFKWQCIGIPLKSETDGGYACGYALIQHYLEKTGKSIYEATITPTADILKETESFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJM1</accession>
    <name>A0A173XJM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262740.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51844">
        <property type="protein sequence ID" value="CUN51844"/>
        <property type="gene ID" value="ERS852471_00050"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1740924at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="22228" checksum="635E5CD98C834F2C" modified="2016-09-07" version="1">MLPSREEAIELLREAERCNPGPWGNHSRVVAHCAEKIALECDDLDSNKAYILGLLHDIGRKFGVRHLGHVSDGYSYMMSLGYNEVAKICLTHSFSNLTTDEYIGNFDTMEDELKLIQEALKSSTMDEYDRLIQLCDALAGAEGVLDIEERMRDVKCRYGSYPQAKWDSNLALKEHFEAKMGKDIYEVVDKDNFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLN8</accession>
    <name>A0A173XLN8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF1659)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262778.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52842">
        <property type="protein sequence ID" value="CUN52842"/>
        <property type="gene ID" value="ERS852471_00071"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971409at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012454">
        <property type="entry name" value="DUF1659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07872">
        <property type="entry name" value="DUF1659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="74" mass="8031" checksum="78142B32591834D6" modified="2016-09-07" version="1">MAANKELQKVSLAFKLENGTDDEGNTVYKTKSFANVKGNVSAEAIFDVAEGIKTVLKNDAVAYYLNETSLIQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMT4</accession>
    <name>A0A173XMT4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyamine-transporting ATPase</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
            <ecNumber evidence="5">3.6.3.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD_1</name>
        <name evidence="5" type="ORF">ERS852471_00058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EC" id="3.6.3.31" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262752.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52256">
        <property type="protein sequence ID" value="CUN52256"/>
        <property type="gene ID" value="ERS852471_00058"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN52256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="27665" checksum="EE9ED795105EF953" modified="2016-09-07" version="1">MGEILKLNNLSKDYGIKGFKTRVLNNISLSVEEGEFLSIMGPSGAGKTTLLNLLSTLDKPTKGEILLDGIDITKVKNKELSNIRKDKIGFIFQDYSLLDNMTLMDNIALPLALGRKKSKEIEDKVIRMVDIFGLTEHLKKYPYELSGGQKQRGAAARALITEPKVIFADEPTGALDSKSSIDLLECLKRVNEENKATIIMVTHDAFSASYSKKVYMLSDGEIKCQLNKGNDRKEFYGKIIDLLATLGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQW7</accession>
    <name>A0A173XQW7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262793.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53326">
        <property type="protein sequence ID" value="CUN53326"/>
        <property type="gene ID" value="ERS852471_00081"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2050907at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11532">
        <property type="entry name" value="NTP-PPase_COG4997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038735">
        <property type="entry name" value="MSMEG_1276-like_NTP-PPase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="102" mass="11801" checksum="20A276902EA6A2F3" modified="2016-09-07" version="1">MKKYNKLVRDLIPEVIKTDGKACEIEIAKDEEKTELLEAKLMEEVNEYLKDKNLEELADVMEVLFGLAHNLGYSEEDLLNKRNEKLKARGGFKEGIVLKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTJ3</accession>
    <name>A0A173XTJ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262811.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53678">
        <property type="protein sequence ID" value="CUN53678"/>
        <property type="gene ID" value="ERS852471_00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="29388" checksum="F29CE7FC1B61C24F" modified="2016-09-07" version="1">MASKGEKAKSKKTIEAKNTVDSKKEDNVRIVFEYSKERYNYMIKQKEHIDRNSIYLLLIISISALFLIFNGVGLLYDNTELVISDYLYIGTFVVLILDILILVASLKNTFIKKKVFRYLFKKIYKIDIYKDLELKDKIDDAVKSKEKSYKRKLTRDEKKRVARKTIRESCCYREMDDPVEIMKISKRRYSEKTDKFYEYLIKLISPRINEGNVINKIKQICFNISLGLFIISMILIFINTIVYIYLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XUR3</accession>
    <name>A0A173XUR3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybaK</name>
        <name evidence="5" type="ORF">ERS852471_00128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262883.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55419">
        <property type="protein sequence ID" value="CUN55419"/>
        <property type="gene ID" value="ERS852471_00128"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN55419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="17338" checksum="2A1483A0B091A669" modified="2016-09-07" version="1">MTKTNAMRILDKNKIKYEVIEYDISDGKIDGVSVAEKTNQDVKEVYKTLVTQGNTKTIYVFVIPVNEELNLKKAAKVCGEKKIDMIHVNDILKLTGYIRGGCSPIGMKKLYKTFIHKDAESLDRVCVSGGKKGLQVKLSPQDLQNVSNAIFEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4Q3</accession>
    <name>A0A173Y4Q3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">mutL</name>
        <name evidence="7" type="ORF">ERS852471_00192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263004.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58653">
        <property type="protein sequence ID" value="CUN58653"/>
        <property type="gene ID" value="ERS852471_00192"/>
    </dbReference>
    <dbReference type="OrthoDB" id="764332at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="463"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN58653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="649" mass="73943" checksum="FB59BB4318212CCA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4V3</accession>
    <name>A0A173Y4V3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murR_1</name>
        <name evidence="3" type="ORF">ERS852471_00184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262989.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58226">
        <property type="protein sequence ID" value="CUN58226"/>
        <property type="gene ID" value="ERS852471_00184"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1540164at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="132"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN58226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="297" mass="33144" checksum="0224180375C80FBA" modified="2016-09-07" version="1">MEKNNNCESNDLMRLIQTKFTRLSKGQKLIADYILKNYDKAAFMTASKLGEAVGVSESTVVRFAIELGFSGYPKLQKSLHELIKTKLTTVQRLELSNDYISNGYTLKGVLKSDMENIRATMEKIDYETFDAVVNSIFEAKRIFIIGLRSSMALAEFLEFYLNLILQNVKTVGNGISDIFEQMVSIREGDLVIGIGFPRYSSKTIDALGIAQDRGAKVVAITDSYLSPLDAKADYTLVAQSNMASFVDSLVAPLSVINALIVAVGLREKETISNIFNDLEKIWHDFNVYSYNGRNSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4V5</accession>
    <name>A0A173Y4V5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF378)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263023.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59191">
        <property type="protein sequence ID" value="CUN59191"/>
        <property type="gene ID" value="ERS852471_00202"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1970874at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="72" mass="8095" checksum="46F1D29156D81B18" modified="2016-09-07" version="1">MFKLNIFDKLSFFLVIIGAINWGSIGLINKNFIYYLAGGSSIILRIIYVLIFLAALDLLYLLVKGNVIKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9X9</accession>
    <name>A0A173Y9X9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263057.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60380">
        <property type="protein sequence ID" value="CUN60380"/>
        <property type="gene ID" value="ERS852471_00223"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077111at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="64" mass="7398" checksum="3482641CE480AD5D" modified="2016-09-07" version="1">MISKKALKDEIITYDIITYTDESGEVVNYVEVTLVDRIIDVYMDIKEVNIGLIANKIIEDNLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBG4</accession>
    <name>A0A173YBG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenium metabolism protein YedF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263089.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61472">
        <property type="protein sequence ID" value="CUN61472"/>
        <property type="gene ID" value="ERS852471_00240"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019870">
        <property type="entry name" value="Se_metab_YedF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03527">
        <property type="entry name" value="selenium_YedF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="21874" checksum="F8BBC28D25BE6DF2" modified="2016-09-07" version="1">MKKVIDAKGKACPMPVIMAKKEIDLGTKFFAIEVDNNIAVENLKKLANSQGFEITIEETEGIYLVHFSNGCEECQEVLNKIQGKKPLGDWCIFVGKDIIGAGSEELGKSLMKMFFYTLSEDEDLPKAVLFMNDGVKVPTLNEQAIEHLEVLAQKGVNVLVCGACLNYYNLENELKVGTVSNMYDIVGVMKSISKVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJC5</accession>
    <name>A0A173YJC5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263147.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64242">
        <property type="protein sequence ID" value="CUN64242"/>
        <property type="gene ID" value="ERS852471_00258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="194" mass="22204" checksum="5B0E809B3E8BAF47" modified="2016-09-07" version="1">MWQDVLMIIAIGLSVYSIYDFGSMIIKKIINNTKISKKIYSFKGKIRYYPLLGLIIFMSNLIGLTKKSDEEIIISKYMLSVMVQKLYSKSGTLNKLTIGILSLFLIINFILSILVKPIMYEEGIVCYDGNFLSWDKIKSITTVQNQIGSRKFIVINTANKEIYLRVANSESNKVKEIIFNKTGIVNKEIVTEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNT1</accession>
    <name>A0A173YNT1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cymR</name>
        <name evidence="1" type="ORF">ERS852471_00262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263153.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64438">
        <property type="protein sequence ID" value="CUN64438"/>
        <property type="gene ID" value="ERS852471_00262"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN64438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="150" mass="16952" checksum="3ACD213F167AF812" modified="2016-09-07" version="1">MKLSTKGRYGVKAMVELAINHGKSPLSIKTISQRQGISEYYLEQLFSPLRKAKLINSIRGAQGGYVLGREPKDIKVSDIMYVLEGPIEIADCIEGVSCDNIDCCATRLLWTKIKNSIDEVMENITLQDIVDDYNRIKEKNETLVLKRSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQL1</accession>
    <name>A0A173YQL1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">ERS852471_00283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263187.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65496">
        <property type="protein sequence ID" value="CUN65496"/>
        <property type="gene ID" value="ERS852471_00283"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="207"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN65496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="39960" checksum="C7EDD02891BAD8D2" modified="2016-09-07" version="1">MLDFELDMQELTNIKVIGCGGGGGNAVNRMVLEGLRNVEFIAVNTDKQALLLSHANTKIQIGEKLTKGLGAGANPEIGKKAAEESREEIAEAIKGANMVFITAGMGGGTGTGAAPVVAEIAKSMDILTVGVVTKPFPFEGKRRMRHAEMGIENLMQKVDTLVIIPNEKLLAMADKKTTLLDSFRLADDVLRQGVQAISDLITIPGVVNADFADIETVMKNKGLAHMGVGYGKGDNKAQDAVRQAISSPLLETSIDGATGVIINFTGGVDLGAIEVYEAAEIVREAADMDANIIFGAVIDETLNDEIRLTVIATGFEDDNAKSSLKASEPKMEIKTPITQKVEEVVKEEVVSKVDPLLDIDRESVNIPSFLRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBU6</accession>
    <name>A0A173ZBU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase family protein</fullName>
            <ecNumber evidence="1">1.3.8.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crtN_1</name>
        <name evidence="1" type="ORF">ERS852471_00437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.8.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73771">
        <property type="protein sequence ID" value="CUN73771"/>
        <property type="gene ID" value="ERS852471_00437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102223">
        <property type="term" value="F:4,4'-diapophytoene desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="339" mass="38699" checksum="DB041E96F31658EB" modified="2016-09-07" version="1">MPKALNFKAFTSSYDDAKKYIKNEKLLDYLMFQSMYVGISPYTSPSIYNIIPTITQYYGLYHIKGGMYSYIKALEQLIIDKGGIIHTSSPVHKILFKHNKANGIVVNGQNRYSDIVVCSSDYSYTIKSLIKDKDIRTFIKPIDDLEYSCSTFILYLGLNKKYPNLNIHNIYINNNFKKNIEDTFNGYLPKDLSMYIYCPSSVDDSICPKNCEAINIIIRVPNTLSNKVTWTSETIYYLTKKILKTLSSISGLEDITEHIVYINHLTPLDFKNKFNTYGGCAFGLSHTLKQSIIFRPQCQIPKIKNLFFTGASIHPGNGVAMVLKSSKICATKINKMYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDG7</accession>
    <name>A0A173ZDG7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal-transduction and transcriptional-control protein Stc</fullName>
            <ecNumber evidence="9">1.14.13.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">stc</name>
        <name evidence="9" type="ORF">ERS852471_00433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.48" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73526">
        <property type="protein sequence ID" value="CUN73526"/>
        <property type="gene ID" value="ERS852471_00433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="314"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN73526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="622" mass="70361" checksum="CCBEA8D470FBA8AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSG1</accession>
    <name>A0A173ZSG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
            <ecNumber evidence="3">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdaA_1</name>
        <name evidence="3" type="ORF">ERS852471_00495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263587.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79174">
        <property type="protein sequence ID" value="CUN79174"/>
        <property type="gene ID" value="ERS852471_00495"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="92"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="295" mass="33756" checksum="A2167BA82D1AF593" modified="2016-09-07" version="1">MHKGKIAFIICYIIAVCTVSVFMIVGIKIYKTEDEIAEMQEREVAASFDEIEEAKRKELNYLSLSEDPNADDAKIVENALVKWNFQSTEGRKIAYLTFDDGPSTKVTSEVLDVLKEHDVKATFFILGSMLEKSEDSRMALIRMVEEGHAVGNHGYCHKYEVLYPNSYVNVNAFMNDMDKSLESMRSVLGEEFNTRVIRFPGGHNSWRTSAIDKVLVEKDYAFIDWNIVNGDAHSAVLSKDQMMNNLKKYVKKMDKNNDTIVVLMHDTDKNINEAAFLNEAIPYLKELGYEFRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZU99</accession>
    <name>A0A173ZU99_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79393">
        <property type="protein sequence ID" value="CUN79393"/>
        <property type="gene ID" value="ERS852471_00499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN79393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="42" mass="4999" checksum="D15932398B719768" modified="2016-09-07" version="1">MSKIVSIFSGRIISPFLQQIKYTVYNRSIFTFLENMIKLNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5U6</accession>
    <name>A0A174A5U6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RSAM-modified six-cysteine peptide SCIFF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003371542.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82758">
        <property type="protein sequence ID" value="CUN82758"/>
        <property type="gene ID" value="ERS852471_00544"/>
    </dbReference>
    <dbReference type="GeneID" id="66573292"/>
    <dbReference type="OrthoDB" id="2051939at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023975">
        <property type="entry name" value="Six-Cys_pep_SCIFF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13165">
        <property type="entry name" value="SCIFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03973">
        <property type="entry name" value="six_Cys_in_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN82758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="45" mass="4891" checksum="CABC3EEB994CBD6E" modified="2016-09-07" version="1">MKHIKTINKTNIKNSLCKPGCKECANSCQSACKTSCTVANLECEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7R9</accession>
    <name>A0A174A7R9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdtaR</name>
        <name evidence="6" type="ORF">ERS852471_00566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263709.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84524">
        <property type="protein sequence ID" value="CUN84524"/>
        <property type="gene ID" value="ERS852471_00566"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="5">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="183" mass="21120" checksum="3AE968F72A208628" modified="2016-09-07" version="1">MQERIVIAINNLDVADKLRMVLSNAGYYIVATTKSGNELTRIVRSNDISIVLIGYKLSDMTIMDVYDNIGELTSFLAIVNEQHKAYIQEEVDIFCITSPINNAVLLNSIDMVIQSQRRFGIYKKKIHSLEQKIEDRKFIDKAKGKLMKIEAISEEEAFRYIQKQAMDRRKTIREIADEILDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AB36</accession>
    <name>A0A174AB36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263733.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85423">
        <property type="protein sequence ID" value="CUN85423"/>
        <property type="gene ID" value="ERS852471_00578"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN85423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="18030" checksum="1DCA0521ECD48EA7" modified="2016-09-07" version="1">MKEYKFEAEIKKVDGKDASYIEIPFDVEKEFGAKRIKVKASFDGIEYRGSIVKMGLPCYMIGLTKDIRNKIGKTYGDTVKVIVERDVEERIIEIPEELKLRFNDNKEAYDFYNDLSYSQKKKYVTWINSAKKKETFEKRINDTIIKLSNKEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AD73</accession>
    <name>A0A174AD73_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lptB_1</name>
        <name evidence="5" type="ORF">ERS852471_00593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263763.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86581">
        <property type="protein sequence ID" value="CUN86581"/>
        <property type="gene ID" value="ERS852471_00593"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN86581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="33570" checksum="1845BFCE025B0514" modified="2016-09-07" version="1">MAKIEIKNLRKKYDDNLVLDDISLTFEENKIYGVLGRNGAGKTTLLNIITNRVFQDDGTVEVDGENIRENDKALEKIYFMTERNLFPEGYKVKDIFKYTKEFYPNFNMSYALELSKKFDLDISKKIKNLSTGYSSIAKIITAMASNAEIVIYDEPVLGLDANHRELFYKELMKDYIENPKTIILSTHIIEEVSSLLENVVILNDRKIVNTEESEELLNKVYTVSGLGQNVDKYIEAKEIVNIESLSNYKSVTVLGEINNKDKELAENLGLEFSKVELQKLFIYLTNKGESHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BVV9</accession>
    <name>A0A174BVV9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264310.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03775">
        <property type="protein sequence ID" value="CUO03775"/>
        <property type="gene ID" value="ERS852471_00860"/>
    </dbReference>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018769" evidence="1">
        <location>
            <begin position="34"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="51625" checksum="780D1F98AA38D147" modified="2016-09-07" version="1">MKIKKLLAMTIATAVIASAFVGCGSSTTEKTEGDSTTKTEDSENTDKSATEIYFLNFKPEIAEVYDKIVADYESETGVKVKVQTAASGTYEQTLKSEMAKSDAPTIFQLNGPVGYQSWKDYCADLKDTELYSHLLDKTMAITSEEGVYGIPYAVEGYGIIYNDAIMQKYFALDGAKVKSMDEINNFNKLKEVADDMQSKKDELGIKGVFASTSMSSGNAWRWETHLANLPFYYEFKDNTTAGTVLETGLEANTVEFKYADNYKNIYDLYTTDSTTEKGLLSAKTVDDSMAEFALGQCAMVQNGNWAWSQINGVDGNTVKEEDIKFLPIYTGVSGEENQGICVGTENYFAINSKVSEEKQKASAEFINWLFTSDTGKKYVSNDLGFIAPFDSFEESEKPSDPLSKEVLRWMEDSNISSVPWIFQSFPSQNFKDTFAASLLEYVQGSKEWSDVVTTVKDTWAAEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BW14</accession>
    <name>A0A174BW14_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_3</name>
        <name evidence="7" type="ORF">ERS852471_00861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264270.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03835">
        <property type="protein sequence ID" value="CUO03835"/>
        <property type="gene ID" value="ERS852471_00861"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO03835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="31818" checksum="31DED7B5086E7465" modified="2016-09-07" version="1">MQKNIKKYFWFFVLPTLVAFIIAFLIPFIMGIYLSFTEFTTVTNAKFVGLSNYIKAFSNKDFLRSFIFTAKFAVVSVITINVLAFTFAYMLTRKLKGTNIFRTVFFMPNLIGGIVLGYIWQIILNSILYYFGITITYDPKYGFWGLVLLMNWQQIGYMMIIYIAGIQSIPGELIESARIDGASKWQTLKSITIPMVMPSVTICLFLTVSNSFKLFDQNLALTDGAPGNKTAMLALDIFKTFYGRVGYEGVGQAKAVVFFILVAVIMLIQLKITRKKEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BWM9</accession>
    <name>A0A174BWM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage LambdaCh01, N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264274.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03988">
        <property type="protein sequence ID" value="CUO03988"/>
        <property type="gene ID" value="ERS852471_00864"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO03988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="17232" checksum="2AE639ABDC5CEB71" modified="2016-09-07" version="1">MKINKGLLNIGENLEELKDPQYIIIHHTEEEGWNFYDTNNYHISLGWECIGYNYFIEADGKIFEGRGMKVGAHTKGMNIKSIGICLSGNFDIEIPKQEQLISLKKLCTFLIKKYNISIERVIGHREVENCKKTCPGINFDMDQFRKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAX8</accession>
    <name>A0A174CAX8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264487.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10622">
        <property type="protein sequence ID" value="CUO10622"/>
        <property type="gene ID" value="ERS852471_00965"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO10622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="18865" checksum="7203E89CC7E1DA58" modified="2016-09-07" version="1">MKRSYIPNAFTFINLSLGICSILSTIDGNYALASIFILLAGLIDRYDGRIARFLNASSELGKELDSLADLVSFGVAPSILSFLLFNFKGVGPTSLIGFIVLLTFPICGAFRLARYNVSTFDGVFAGVPITIAGCFMALFILLTINVNMSAVIPMLLMIVFSYLMVSNFKLKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CD06</accession>
    <name>A0A174CD06_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine protein kinase PrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264497.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10963">
        <property type="protein sequence ID" value="CUO10963"/>
        <property type="gene ID" value="ERS852471_00972"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49410at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016230">
        <property type="entry name" value="Ser_kinase_PrkA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000549">
        <property type="entry name" value="Ser_prot_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="640" mass="72847" checksum="2B6630F4B1C55364" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CEN4</accession>
    <name>A0A174CEN4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264513.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11377">
        <property type="protein sequence ID" value="CUO11377"/>
        <property type="gene ID" value="ERS852471_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019117" evidence="2">
        <location>
            <begin position="28"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="241" mass="25953" checksum="28B6534C429F2BD8" modified="2016-09-07" version="1">MNKYISKFMVTLAVAVAAISYPVVAEASVETFTISKYSESFVPAENSDAILNIEMTAKTSDEGIVYIPVSVEDSELINASIDGQAVDGELTKVGSVSYFTLNSEMPETEVNVIAEVSCKDFYAVENDDPETGIPTALMEYKFTNKSSNKIESYNLTIALPNGMEPISVMTPSNVTKYTLSENEAGQRTLSLNGGVAVAGSSTFKFTFGKPFTNSTVAVVAIWVVVIGISAFVIKERLKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIE8</accession>
    <name>A0A174CIE8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yiaM</name>
        <name evidence="8" type="ORF">ERS852471_00984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264519.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11548">
        <property type="protein sequence ID" value="CUO11548"/>
        <property type="gene ID" value="ERS852471_00984"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947990at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO11548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="18464" checksum="6E0190E64943F708" modified="2016-09-07" version="1">MKEQSLFKRILSNFEEIIAGTFIMITTVLVVINVFLRYFMKTGLYWSEEVATICFVWSVFIGAAASYKRGQHIGVDIIVNKLPKTIRNIVVILVDLILILLNGYITYIGVIYISRSYIKPTAVLGISSAYVSSSLVIGFALMTMYSIIFLVRDFKKIKEENNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJ03</accession>
    <name>A0A174CJ03_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">siaT</name>
        <name evidence="5" type="ORF">ERS852471_00983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264517.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11506">
        <property type="protein sequence ID" value="CUO11506"/>
        <property type="gene ID" value="ERS852471_00983"/>
    </dbReference>
    <dbReference type="OrthoDB" id="903568at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO11506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="427" mass="45849" checksum="10FB4B476DD42B02" modified="2016-09-07" version="1">MAFLPILIVFLLYFTGIPIAYALFGATLSYFTFLDHGAPVDLILQKFITSAQSFPLLAIPFFILAGSIMNYAGISGKLMKFAEVLTGHMKGGLGQVNVLLSVLMGGVSGSANADAAMQCKMLVPEMEKRGYKKATAAAITAASSAVTPVIPPGINLIVYALIASVSVGKMFMAGYIPGILMAVALMITVNIIAKKRGYMPTREKRATLGEIARQALDSIWALLFPFGIIAGLRMGVFTPSEAGAVAVVYCIIVGVFIYKNLKVSHIPAIIKETVYGTSTVVLIIIAASVFGYYMTWQMIPQQLTGLLLGITSNKYLMLLLINILLLLLGMFLEGGAALIIIAPLLVPVVTKLGVDPIHFGLIAIVNIMIGGITPPFGSMMFTCCSMTDCKLEDFIRESIPFIIAMLISLLLITYIPQISLLLPNLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNN7</accession>
    <name>A0A174CNN7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadR_2</name>
        <name evidence="3" type="ORF">ERS852471_01017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264547.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13378">
        <property type="protein sequence ID" value="CUO13378"/>
        <property type="gene ID" value="ERS852471_01017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="194" mass="22419" checksum="68F3094B77D0AF21" modified="2016-09-07" version="1">MSKCTRKQIEKRKQIIEATKSIMDEIGFENVTVRGICKAANISIGTFYHYFNDKGDIIIQLYTSVDEYLSEIEIEKLSDEDELKNIITFSEEYGRFVADSGLSVAKQIFGAAINTESDQIYRSIERDINRIIFNIIKRAKEKEQINTDFSTEEISNMILINIRGIVFDWCKFQGQYDLVAQIRNSISIFVRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWF1</accession>
    <name>A0A174CWF1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATPase</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gsiA_5</name>
        <name evidence="5" type="ORF">ERS852471_01052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264586.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16449">
        <property type="protein sequence ID" value="CUO16449"/>
        <property type="gene ID" value="ERS852471_01052"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO16449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="29313" checksum="918E68D882489438" modified="2016-09-07" version="1">MKKPLLQLKNISIKYDDKLVVNNISMSVYEGEILGIVGESGSGKSTLIKSIIGILGDGGRIVEGSIIYEGKDITNLNKKELMAIRGQAIGMIFQDCKSSFCPIRTIGNQLYDSMRAHMKITKKEALIRGEEILRELNIKDPKKFLNSYPFELSGGMNQRAGIMMAMASNPKILLADEPTSALDVTVQRKVIDELMNLRNKFGTTIIIVSHNMGVISLISDNALVMKNGECIEYDSTEKIFNHPTKRYTKELINAMPKLRNEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8L0</accession>
    <name>A0A174D8L0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264680.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22092">
        <property type="protein sequence ID" value="CUO22092"/>
        <property type="gene ID" value="ERS852471_01166"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO22092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="203" mass="24381" checksum="5A0A720C6E7EFCC3" modified="2016-09-07" version="1">MIEQDYERLLNIETKKEQKNFHQSLHYNRYEATPYSALELLFKEYKVCDSDYIVDYGCGKGRLLFYINHFFNSNVTGVEMDKNFYNDCLSNTNSYLLNHKKSIGKINFVNDFAENYIVSEKDNKFYFFNPFSIQIFMKIVDNILESIEKCNRVVDIVLYYPSDDYIYYLESCTAFTLIKEVKIDELFIKDSRERFLVYRLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DA21</accession>
    <name>A0A174DA21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264687.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22394">
        <property type="protein sequence ID" value="CUO22394"/>
        <property type="gene ID" value="ERS852471_01173"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO22394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="306" mass="34201" checksum="CDFA195BEDDC0636" modified="2016-09-07" version="1">MKVLEVNNLKKTIGKREIIKGVSFEINSGEIFGFLGPNGAGKTTTIRMLVGLIKPTDGEIKICGHDLKKNTSKALKEVGAVVENPELYKYLSGRENLMQIARIRKISKEQVEETIKLVGLENRIDDKVRKYSLGMKQRLGLAASLLSRPKLLILDEPTNGLDPSGILDFREVVQKAARERDMAVFVSSHILSEVQNLCDKVAFINDGVIKAVEDINKESNTMETDSDVVCLVSNDDNNILVKEISKLSYISSCNESDKGLKIIMECNSTPKLVKHLAMNNFSIEEIYKERKGLEQRYMELVEGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEA0</accession>
    <name>A0A174DEA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264692.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22639">
        <property type="protein sequence ID" value="CUO22639"/>
        <property type="gene ID" value="ERS852471_01179"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TM1586_NiRdase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="287" mass="33131" checksum="86E9D005A99FECC8" modified="2016-09-07" version="1">MSNTSSINKTISEIIKERTSVRTYEECEIDEDKIVKIEEYINNLKGPFNEKVRFKLINSKEPLKGEKIGTYGIIKGANNFIAVAYENGEMALEEVGYEMEKVILYITSLGLGTCWIGGTFNKGEFSKSMELKEDEVLPIVTPFGKSGENKRFIEKTMKFLTKSKKRKEWYEIFFLRDFSVPLTPVINLGYFKEVLENVRLAPSALNKQPWRIVKDGNKFHFYINSSKKKNDKLTFDIHRIDMGIAMCHFDLTCKELGLEGRFIKCNPEITDTPKNISYVITWVHESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQJ1</accession>
    <name>A0A174DQJ1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase, iron-sulfur binding subunit</fullName>
            <ecNumber evidence="3">1.17.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndhS</name>
        <name evidence="3" type="ORF">ERS852471_01252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264789.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27477">
        <property type="protein sequence ID" value="CUO27477"/>
        <property type="gene ID" value="ERS852471_01252"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050138">
        <property type="term" value="F:nicotinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO27477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="158" mass="17104" checksum="FC1F4D1377A41E42" modified="2016-09-07" version="1">MSNNIKFNLNGKDVTYDGNASDRLLDILREYYKLTGVKCGCKEGECGACSILMDGELVNSCTVAMGRCEGSKIVTIEGFRETERFKVIDKAYASVSAVQCGYCIPGMVLATEAILSKTPHPTIEQIREGISGNLCRCTGYNAIVKAIKVASEEGNGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTX0</accession>
    <name>A0A174DTX0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family protein</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lyc_3</name>
        <name evidence="5" type="ORF">ERS852471_01284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205665.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28933">
        <property type="protein sequence ID" value="CUO28933"/>
        <property type="gene ID" value="ERS852471_01284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="395"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="449"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="493" mass="53396" checksum="C90A2731DB563062" modified="2016-09-07" version="1">MTNYRGIDISNWQGSITFSEVKNSGIEIVYIQATEGNYYTDPYLQEFYDGAKDNGLLVGFYHFFSPSISAIVQARYFADAISGLTSECRLVLDLEEAGGYEVGTLSSIAVEFLEEVKKITGLDVAIYTYASFANNNITTGFGLENYPLWIAEYGSSEPEENSIWGNAYVGWQYSDTGNISGINTNVDLDIFKEGILLSDDTTVPGNKKQESTQSGVKYYVVQAGDTLSSIAARFGTTVASLVSINSIANPNLIYVGETLKIYTDKTVSTRTNSFSKTYIVVSGDTLSSIALRFGTTVNELVQLNNITNPNLIYPGEVLKIPTNVSVKSGATSNQHSSTYVVQSGDTLSGIASKFGITVQYLARINGISNPNLIYPGEVLKIESSGVSKQEQSESLIYTVKAGDTLSGIAKKYGTTVSNLVSLNNISNPNMIYVGEKLIISKDKSKNFTGLVVVKTGDTISGIAARYNTTVDNIVNLNDLQNSNLIYPGETLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECZ5</accession>
    <name>A0A174ECZ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">punA</name>
        <name evidence="6" type="ORF">ERS852471_01413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265075.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35553">
        <property type="protein sequence ID" value="CUO35553"/>
        <property type="gene ID" value="ERS852471_01413"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO35553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="29642" checksum="6E989E5133F36F06" modified="2016-09-07" version="1">MDLLTQIKASADFILSKSNYKPEIGLILGSGLGSLADSIENPEFYNYSDIPNFPTSTVEGHAGRLVIGTLGGKQVVAMQGRFHYYEGYSMEKITFPVRVMKLLGVSKLIVTNACGAVNKDFNAGDLMVITDHINFSGSNPLFGHNLDEFGPRFPDMSEAYNLELRNKVLNVGKELGIDLKQGVYVMFSGPTYETPAEVKFARIMGGDAVGMSTVPEVIVANHCGIKTVGISCLTNMAAGILDQPLNHEEVIETSARVKNDFIKLMNRVIEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EDL1</accession>
    <name>A0A174EDL1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic ribonucleoside triphosphate reductase</fullName>
            <ecNumber evidence="5">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrdD_2</name>
        <name evidence="5" type="ORF">ERS852471_01420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265087.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35934">
        <property type="protein sequence ID" value="CUO35934"/>
        <property type="gene ID" value="ERS852471_01420"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO35934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="703" mass="80025" checksum="D38422C923B2CB3D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EE08</accession>
    <name>A0A174EE08_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265093.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36084">
        <property type="protein sequence ID" value="CUO36084"/>
        <property type="gene ID" value="ERS852471_01423"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="67" mass="7515" checksum="FF62537D02BF0045" modified="2016-09-07" version="1">MKGTILDYTPTEVFVLLEDDSVVTLPLSSFSHTSPIGSNISLDRLYNGTYSINYKPSNIHDKSIDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEJ2</accession>
    <name>A0A174EEJ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic trypsin-like serine protease</fullName>
            <ecNumber evidence="4">3.4.21.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mucD</name>
        <name evidence="4" type="ORF">ERS852471_01405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265059.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35148">
        <property type="protein sequence ID" value="CUO35148"/>
        <property type="gene ID" value="ERS852471_01405"/>
    </dbReference>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="273"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="371" mass="40686" checksum="0514D8D95D75F014" modified="2016-09-07" version="1">MVRNKVQREKIKNYEEKDYNISFKKKRTKSSIRFGAKLFIYLIIAAGSGAVFSGIMMDIKYGNAIKIIEEFANDEMIITDYTKIINTINPSIVTIENSSEGFNLNNENNTTGIILDESGSILTNYSLIKDFSNIVVKLSDNSVEPINAKLMVKNEDIDLAIIKIKTDEELTPVKFAKSDELLIGQGVAVLGKTVGDNTVDTVSPGIITSIEENTRLEGKSYQLLQISAPINKKNAGGPICNSKGEVIGLASYSLSEANKDSGFYYGIQIRDLQIVINSSNAFKSVLGINEGGIIADKNTEYKGFYVQDLDKNGDAYKAGIKPTDIILEVDNTPIITVDDATAVLQNKKPGDVLKCTVLREGTIEEIEVNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJI4</accession>
    <name>A0A174EJI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3D/G5 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yocH_3</name>
        <name evidence="4" type="ORF">ERS852471_01432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265109.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36395">
        <property type="protein sequence ID" value="CUO36395"/>
        <property type="gene ID" value="ERS852471_01432"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="158"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="38247" checksum="67D8D65CF488530E" modified="2016-09-07" version="1">MIEKCKEYLKRNFSNSPKAKILLCAIVTVVIALSVASLRKTVTLVVDGNEVKVTTFKGTVKDLVLDQGIELTEKDKVQPALDDRLSEGEKITITKAVEVQLITMDKELSILTAEKTVEDMLDAEYEALKSQGIEFIKNIDEVEPNLDTKIQKNLQIKLVKVEEVKEVATETIQFDTVTEEDGSLDISVEEIRQEGVPGQKEITYRILKKDGKEVSREVVGSKVVAEPVNKIIVQGTRRTFASRSGEVLDYKELLYCESTAYTGDGITATGTVPVYNPNGISTIAVDPRVIPLGSLVYVDGYGKAVAADTGGAIQGSIIDIYVNSHDHATSWGRKYGVPVYILAYPGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKG4</accession>
    <name>A0A174EKG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265165.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37757">
        <property type="protein sequence ID" value="CUO37757"/>
        <property type="gene ID" value="ERS852471_01464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="217" mass="25517" checksum="182839DD1779E88A" modified="2016-09-07" version="1">MDKFDEFLKKKTEDENNEFTLPESFNLKIEETLKCLEDNKKEKWYKNRKIISMVACFALVFFVGLRYTVFNGSLTINESTTMDMQSDSVQRSSIPEPEISNYSLENSEDFIINQNEVKELTIKSLSGEAKFKFVNKEEDINNIIESINKLYKFEVIDQGISEWDFLIQTTGEVNHTIEVKGNLINIDNRCYESNEDISEIIRNIYDNLNYEEKNIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EL64</accession>
    <name>A0A174EL64_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">ERS852471_01483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265198.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38762">
        <property type="protein sequence ID" value="CUO38762"/>
        <property type="gene ID" value="ERS852471_01483"/>
    </dbReference>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="318"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO38762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="45335" checksum="B767F0AF96433E21" modified="2016-09-07" version="1">MSELILKGQKAKEASNILGNLSTGEKNKGLLAMADYLVKYKDFIIEANKIDLQEAVNRGTAKAMLDRLSLDEKRVEGMANGLRQVASLPDPVGEVVSMWTRPNGLQIGQKRVAMGVIGIIYEARPNVTSDAAGLCFKAGSAVILRGGKEAIYSNKAIVKVLIEALKSVDLPENSIQLIEDTSREVATEMMRLNDYIDVLIPRGGAGLIKAVVNNATVPVIETGTGNCHIYIDEECDFEMAKNIVINAKTSRPSVCNAAEKLLVNEKIADDFMPFILKELRASGVEVRGDESAIAYDKDIILASEEEWYNEYLDYKIGVKVVKDIDEAITHINSFSSGHSEAIVTKSYENSQKFLQRVNSAAVYVNASTRFTDGEEFGFGAEIGISTQKLHARGPMGLKELTTIKYIIYGNGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUW1</accession>
    <name>A0A174EUW1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yccF</name>
        <name evidence="3" type="ORF">ERS852471_01507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265248.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41107">
        <property type="protein sequence ID" value="CUO41107"/>
        <property type="gene ID" value="ERS852471_01507"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1806532at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="13065" checksum="A0487FED4815B3A2" modified="2016-09-07" version="1">MSCLGNIVWIIFGGFFGAIGWIFTGILWCITIVGIPVGKQCFKMAKLQFSPFGKEVITVSDSSTSLILNIFWIIFGGFELCIANLISALILCITIVGIPFAVQSLKLAKLSLMPFGKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ84</accession>
    <name>A0A174EZ84_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265312.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42597">
        <property type="protein sequence ID" value="CUO42597"/>
        <property type="gene ID" value="ERS852471_01541"/>
    </dbReference>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="34931" checksum="332381932E14CF83" modified="2016-09-07" version="1">MNDKLVCCIIVTYNIGNKFNKCYDSIKQQVSKVIIVDNGSNLETVNILNKLIKDKYTDVIFNEENLGIAKALNQGIERAINEEFKWIITMDNDSVATDNMVNTMLQAYESIPDKDKVVSLFPKYIDLGINEEENYNNQNANENVEFLNAEITSGNLIKADIFNKVGLFEEKLFIDMVDYEFCFRISKLGYKLVRVNNAVLQHNLGNMKVKRILGKNIYYTNHNYIRRYYITRNRFYTWNKFDDCNFEELYRDKKFFLKDIIKIILLEEEKNKKIKMIIRGYIDFKKDKYGKFDGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F596</accession>
    <name>A0A174F596_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MORN repeat variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265394.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44727">
        <property type="protein sequence ID" value="CUO44727"/>
        <property type="gene ID" value="ERS852471_01582"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1693280at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="22606" checksum="CB099693F864A18D" modified="2016-09-07" version="1">MGLSIVPKSILKDPIEKKVKVDKKSIKTDEDSFYEIDVLKSRKIEKQLRYQIERDIGLININTESLNGRIYEDGELIYEGEYIQGKGYYSDKWYAHGYGRSYYDNGKLEYEGNFVYGSPHGYGKYFYENGQLRWKGNFQAVVGIEVLKLWKSSLGYVDRRGRIKYGKYYDKEGKLIHCGDFDWMGKPIKYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F724</accession>
    <name>A0A174F724_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3592)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265428.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45491">
        <property type="protein sequence ID" value="CUO45491"/>
        <property type="gene ID" value="ERS852471_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="129" mass="14906" checksum="F799159776F75302" modified="2016-09-07" version="1">MLRSLPFFAFGIMLIVMCIALFKKFFYVLLNCGKTKATVVGIQRYIGDRNNNNYILKYVAEGSEYTIVHDIGSVRIYEKHIGKQLTILYRRDNPKQIILLENFMLYIMGLFFGCVGVWLMIMGIGFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJM6</accession>
    <name>A0A174FJM6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase Obg</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="7" type="synonym">obg</name>
        <name evidence="11" type="ORF">ERS852471_01639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48325">
        <property type="protein sequence ID" value="CUO48325"/>
        <property type="gene ID" value="ERS852471_01639"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="159"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="345"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO48325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="428" mass="47482" checksum="0149A7694B4FA2D3" modified="2016-09-07" version="1">MFIDRAKILVKSGAGGNGAVTFRREKYVPLGGPDGGDGGKGGSVIFTVDTGLTTLLDFKYKKKFVAESGGNGQGSKCYGKDGEDLYIRVPMGTIVRDFETNKVICDLSHKDDTFVIARGGKGGKGNCKFCTPTRQAPHFAEPGMPAEERTLTLELKLLADVGLVGFPNVGKSTLLSTVTAAKPKIANYHFTTLKPNLGVVKAEGINSFVMADIPGIIEGAAEGVGLGLDFLRHIERTRLLIHVVDISGVEGRDAFEDFVKINEELKKYSVKLWDRPQIVVANKADMLYDEEVFEDFKRKVNELGFDKVFKMSAATKSGVEEVIKEAGKMLTEIPIMDLEIPEEERYVEEEKRFTYEIEIEENDGYNTYVVTGSFVDRLLSAVNIHDADSLRYFHKVLRNKGVLDKLREMGIEDGDMVRLNDFEFEYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJX7</accession>
    <name>A0A174FJX7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA replication and repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">radC</name>
        <name evidence="9" type="ORF">ERS852471_01656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265534.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49136">
        <property type="protein sequence ID" value="CUO49136"/>
        <property type="gene ID" value="ERS852471_01656"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="107"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO49136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="229" mass="25631" checksum="905128A517602509" modified="2016-09-07" version="1">MQNNIKISDIPKNERPMEKLLKYGADDLANAELLAVLLRSGTKGENIISLSTRLLSDVGGLDGLLHINLEEIKKIKGIKEVKACQIIAMMELFRRFRTLRSQNDDFKISSPKDISMLLINEMNNLNQEVLKLILLNTKNTVIGVKDVFKGSLNSSIVHPREIFREAVQRGSANIIICHNHPSGDPTPSKEDINVTLRIKQCGDLMGIKLLDHIIIGNNNYISLKEKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FN00</accession>
    <name>A0A174FN00_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybbH_3</name>
        <name evidence="3" type="ORF">ERS852471_01677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265569.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50268">
        <property type="protein sequence ID" value="CUO50268"/>
        <property type="gene ID" value="ERS852471_01677"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="104"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO50268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="28164" checksum="FBB8BA41F054F21D" modified="2016-09-07" version="1">MFSHDKIQSLNELELSLYSYIIKNSEKVIYMRIRELANEAHVSTTTILRFCKKLNCDGFSEFKVKLKLYIENGKSNQLTDNTAMLIDFLKKTETEDFKNKIKQICEIVSGAESVVFVGIGGSGILAKYAARYLSSVGKFAIYLDDPFYPTKCKHYKNSVAIVFSVSGETPTVIDHVNKLKKEKSSIVSITNNENCTLAKMSDINLSYYIQRAKVEDYDISTQVPVLYIIELIGKRLYNYYLRYPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5H9</accession>
    <name>A0A174G5H9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265744.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55595">
        <property type="protein sequence ID" value="CUO55595"/>
        <property type="gene ID" value="ERS852471_01771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO55595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="210" mass="24303" checksum="C95112CD29E0678C" modified="2016-09-07" version="1">MADKFNDNERDLLDVLKYNQDKSSNIINKVDNVNNSLDDRINDTKKLLKNLNIDVMKYPNNSIVNNKSNTNSKNDLEKTWDDIVKEVNEEGYVNTEINDILTTNEQVQVYKKIDEINEQFSKATGLNSTDVKFLFFATTLQCLRQYLISNDKFRFDTDKAGDKFISKFVPRKYEDILLGSVPYDAVRKADGYKDQNTGISCANQTYDFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFM0</accession>
    <name>A0A174GFM0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dapB_2</name>
        <name evidence="9" type="synonym">dapB</name>
        <name evidence="12" type="ORF">ERS852471_01894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265969.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61213">
        <property type="protein sequence ID" value="CUO61213"/>
        <property type="gene ID" value="ERS852471_01894"/>
    </dbReference>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="114"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO61213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="27724" checksum="795F60E3234FBBED" modified="2016-09-07" version="1">MIQILLNGCCGKMGKVITDVISQFPDLNIIAGVDKYPCDTQFPVFTSLSNINTTYDVLLDFSRPTALESLILLSEKTKKPLILCTTGYSSSDLDLIKEKADIIPIFKSANMSYGINLINILLKKITPLLYYNYDIEIIEKHHNQKVDSPSGTALLLANTISNSIDTKTNFVYGRYGKNKRKKEEIALHAIRGGSIVGDHEIIFAGTGEVIELTHKAISREVFAIGALKACEYMSKITSPGLYDMESMLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIT2</accession>
    <name>A0A174GIT2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265952.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60809">
        <property type="protein sequence ID" value="CUO60809"/>
        <property type="gene ID" value="ERS852471_01884"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="260" mass="28942" checksum="7200B000DCCE446D" modified="2016-09-07" version="1">MISIESKENAFFKLAKKLKDRKGRSKEQKYIIEGFRLIQEAFKAGCKVDSIVVNNDGAKKINQYLEQYIDCVKVYLMEDSLFSQLTSTENPQGIIALLEIEDNRENLNGDFYLLCDKVQDPGNLGTIIRTAHAAGVTGIILTKGTVDIYNDKVIRSTMGSIFYVPIIHDNDLTFLKGLKDDGFSLVATSLQESKDFFREDLSGKIILSVGNEGNGISDEIFEMADIKVKIPMPGGAESLNVAIATSIILFERVRQNISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSX4</accession>
    <name>A0A174GSX4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livF</name>
        <name evidence="5" type="ORF">ERS852471_01951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266074.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64357">
        <property type="protein sequence ID" value="CUO64357"/>
        <property type="gene ID" value="ERS852471_01951"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO64357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="237" mass="26022" checksum="6F5BDA6FCE022D89" modified="2016-09-07" version="1">MGKVVLEIEDLNLYYGGIHALKGISLKVREGEIITLIGANGAGKTSTLRAISSLEKIKSGEVYFYGEKINGVSANKLVSKGLSHVPEGRKIFGNLTVMENLELGAYLRKDKAQVKKDYEMVFEKFPRLKERRNQNAGTLSGGEQQMMAIGRALMSRPKMLLLDEPSMGLAPMVVKDIFDTIVEINKSGTTVLLVEQNANMALSIADRAYVLETGTIVIDGKADVLLKDDRIREAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GV72</accession>
    <name>A0A174GV72_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Propanediol utilization: dehydratase, medium subunit</fullName>
            <ecNumber evidence="1">4.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pduD</name>
        <name evidence="1" type="ORF">ERS852471_02008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.28" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266179.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66612">
        <property type="protein sequence ID" value="CUO66612"/>
        <property type="gene ID" value="ERS852471_02008"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1514820at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050215">
        <property type="term" value="F:propanediol dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010254">
        <property type="entry name" value="B12-dep_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003208">
        <property type="entry name" value="Dehydtase/Dehydtase_re"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025541">
        <property type="entry name" value="Ppandiol/glycerol_DHydtase_msu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02288">
        <property type="entry name" value="Dehydratase_MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018506">
        <property type="entry name" value="Prpndl_dhdrts_md"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52968">
        <property type="entry name" value="SSF52968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="23178" checksum="CE2B8A9BE948D571" modified="2016-09-07" version="1">MDQSVLVERITQLVIEELKNNNKVSLDNLFQRAIEEKEAEIGDGKDEVVIGISPTFNQEVKQTLSGANHKDVIKEIVAGIEEEGLKARVIKVFTSADVAFIGKEAATLSGSGIGIGLQAKGTAVIHQKDLYPLSNLELFPQAPLIDLKTYRNIGKNAAKYAKLDNPIPIRVKSDCMSRPKFQVKAALFHIKDTEKVVRGAKSIEISLEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0K8</accession>
    <name>A0A174H0K8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68353">
        <property type="protein sequence ID" value="CUO68353"/>
        <property type="gene ID" value="ERS852471_02039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="39745" checksum="E02E280C64DBA769" modified="2016-09-07" version="1">MGVVAPAVIIVFFSFAFGQEMDYKVGIIDNDNKYISRELIKSINEIEDIDAVGISNDSYELMLVSHQIQMVVIIDDGFSDDILNFKAGKVVIKSISNSDIKETLLSIIKAKVNNLTLIAKVSDGSIDKFIENNKAYTKHMLNYDLNEVNESRPSVKNSIGIVIMMILISGASIANFLIEDEEQDTKNRVLASGIRPYKYYIALLVVFYLMSSMSSIIYYVSCRILNLDFGMENTYNFLVVMLLLNLIAISLNLFIVSFTRNRYIAATINILVVIPTCMISGVFWDFDIMPEYLKKIGSFMPQRLVYEGIEKLQVYESISYIYDYIFYMIVISLILFSLSLFMFRIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H1K3</accession>
    <name>A0A174H1K3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266238.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68141">
        <property type="protein sequence ID" value="CUO68141"/>
        <property type="gene ID" value="ERS852471_02033"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1622875at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="227"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO68141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="38144" checksum="C7C7F4FD18A1FB1D" modified="2016-09-07" version="1">MNHFIIDGRYGSLISSVGLPLREILIKSGLPEDLFSRKNIRLTQDEYFRFMESIGEVMPDESKLIKIATAEGIETFSPPIFAAFCSKNAQTCIERLAQYKKLIGPMIFIIRKEEKSFTVELSTEEKYHKIPLFLEVSEFVFLINLIRIATKENIIPLKITLQNSINNKVLEKYFGCKINKGNKSTLTLSFNDSLKPFVSENEVMWDYFEPELKRRLSELEVEDSFGARVRSSLIELLPIGCSNIEDVALKLGMSKRTLQRKLTEEKTTFQKQLNHTRELLAKNYIKNTDMISDDIAFLLGYQDLNSFLRAFQTWTGMTITEYKKSLQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H229</accession>
    <name>A0A174H229_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266270.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68964">
        <property type="protein sequence ID" value="CUO68964"/>
        <property type="gene ID" value="ERS852471_02055"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085191at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="6973" checksum="63DFD75E52BA510D" modified="2016-09-07" version="1">MPYNAKDNLREVIDELCCCENHLNSAYLHSEGTHNRTEIHAALKAVGSALDSAQYTLLHFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2V7</accession>
    <name>A0A174H2V7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Cytidine deaminase</fullName>
            <ecNumber evidence="6 9">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cdd_1</name>
        <name evidence="11" type="ORF">ERS852471_02062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 9"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266283.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69183">
        <property type="protein sequence ID" value="CUO69183"/>
        <property type="gene ID" value="ERS852471_02062"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="15352" checksum="FAA76849B4FDBAEB" modified="2016-09-07" version="1">MIDKKQLIEKAFAAQEFCYTPYSNFDVGAALLCDNGNIYTGCNIENAAYTPTNCAERTAFFKAISEGEKKFTAIAIVGNKHGIKAGEGDFCAPCAVCRQVMAEFCDLDTFKVIIAKSTEEYLEYTLGELLPLAFTGKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9D7</accession>
    <name>A0A174H9D7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine kinase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71562">
        <property type="protein sequence ID" value="CUO71562"/>
        <property type="gene ID" value="ERS852471_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="179" mass="21248" checksum="8B2143301BF467EF" modified="2016-09-07" version="1">MKFPKNIDINKLQFIGSGTQGSVYKIDDEKCIKIFKKKSHCLKEINTMLMSQVDYHFPILYSYGDKYIIREYIDGIELDKYLLSNSLTPYLSDKLIELYDAMNFVGFSRLDTTLFHILLTDQYELKIIDTARAMKKETIYPKLILEGLDKLNYKNQFLSYVKIVRPDLYNRWNSINNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAR7</accession>
    <name>A0A174HAR7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="9">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisS2</name>
        <name evidence="9" type="synonym">hisS</name>
        <name evidence="11" type="ORF">ERS852471_02105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266363.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71351">
        <property type="protein sequence ID" value="CUO71351"/>
        <property type="gene ID" value="ERS852471_02105"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="24"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO71351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="434" mass="49648" checksum="325C8034F74ABB59" modified="2016-09-07" version="1">MKKNIIKPSILPGFMELLPREQEIFNDIVSKISKVYEMNGCLAIDTPIIEKADVLLAKSGGETEKQVYSFQKGKNNLALRFDLTVPFARYVAQYYNDLLFPFKRYQIGKVYRGERNQKGRYREFYQCDIDVIGKEKLSINNDAWVINLADKAFKEIGLSNYRFQISNRKVLKGILTELEIDNQADVMILIDKIDKIGEEVFISELKNLIGIDKSEYLNKILKLDGSNDEKLEELSKLDIKNEYYNEGVEELKKVKSLLEILGVDKENFEINLKIIRGLDYYTGTVFETILLGDEGYGSICSGGRYDNLAENYTANILPGVGISIGLTRLFFVLKEIGFIDKYKIENKLEYLIIPIGDTIEYCGKVLQYLQSKGYGVSIYLEDDSLKKKMNYANKIGVENVILIGEEEIANNKVKVRNMKSGDNIIINYNLLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLD6</accession>
    <name>A0A174HLD6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">macB_4</name>
        <name evidence="9" type="ORF">ERS852471_02173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266492.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73968">
        <property type="protein sequence ID" value="CUO73968"/>
        <property type="gene ID" value="ERS852471_02173"/>
    </dbReference>
    <dbReference type="OrthoDB" id="724643at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="358"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO73968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="494" mass="53494" checksum="7414416FE1CD8652" modified="2016-09-07" version="1">MDFIFRAIITLKEKLGRTLILLSIMFVISAVVLSSFGIQSATDAAAVLARQKLGANVTLSQNVEKLMQEQRENMAANSAEGEKQGGGAGRFNITRVQVPLEYIDELSSNESVVAYLATNSIQANLDELLAVGASEEETIEETSSKPGFGGGMNMKGSMGDITFTGINDFKTTSAYVNGEAELLEGRELTEDDLGTNNVMIEENFAIANNLEIGSEFNITNISGENLIGVTVIGIYKTYTSIDDNGLRNTAMLPYNNIYSSYTLVNLLNGKAENSGVDSITFYLDDPANVDSFLEYGDSTSIDFDTFILDAGNREYEAMIEPIENVASFSKITILIVAVFGGAILALIIMLSIKDRIHEVGILMSLGEKKFKIIGQFTVEVLTVLLLAIVISVAAGNTISNKMSDILLANELKTEQTEVSNLVTSDRPTKGNKPMIGMNSSSTTVDKIEELNVNISLLDIGKMSGISILIAIIATMLPSLMIMRYNPKQILSKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HM15</accession>
    <name>A0A174HM15_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266498.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74140">
        <property type="protein sequence ID" value="CUO74140"/>
        <property type="gene ID" value="ERS852471_02178"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918179at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="24238" checksum="549DD5892E6D5007" modified="2016-09-07" version="1">MINNDIYIIFSKTGTLFSNVISFFTKKEFAHISISFDPTFQTMYSFGRINPAYVLPAGFVEENLYSGVFSMFPESKCLIYKVSVTSEQYTSLKNHIDKFLMDKSKYKYSVLGTATLLFNKPIKRENYYFCSQFVAEALIESGIYKTDKLPELIRPMDLLDLENKTLLYKGKINKYPLYNLYSTDESYSIFDAPYSLALSAYGKIRNRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQ04</accession>
    <name>A0A174HQ04_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein, PilO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266557.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75606">
        <property type="protein sequence ID" value="CUO75606"/>
        <property type="gene ID" value="ERS852471_02222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="28969" checksum="DFC93B2E3D27389C" modified="2016-09-07" version="1">MEQELNSLEQPKRQNKVVEWLKAQSKKDKIILASTTIIVSVVLSLRFAILPQLEIYTNNLMRLDQLNAEVARVKRLPQENKILEEKAEELQVLYENALVKLPKTPELAQVAYDIRYFVRDTNVELFSLGFSEGQVGEDEIAKKDEVKTDENGVVTEIDRGLEGGNTQTTEVAPEQAVSKQVVSISVSGLHKDIMSFIKKIENYSRIADVSNISLSKGEDKKLNASITANFYNLNYEEKENYEFNDGIYGREDSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HT21</accession>
    <name>A0A174HT21_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmH</name>
        <name evidence="7" type="ORF">ERS852470_03302</name>
        <name evidence="8" type="ORF">ERS852471_02373</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834855</strain>
            <strain evidence="8 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZV01000049">
        <property type="protein sequence ID" value="CUO76477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032116814.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="84024.ERS852471_02373"/>
    <dbReference type="EnsemblBacteria" id="CUO76477">
        <property type="protein sequence ID" value="CUO76477"/>
        <property type="gene ID" value="ERS852470_03302"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81241">
        <property type="protein sequence ID" value="CUO81241"/>
        <property type="gene ID" value="ERS852471_02373"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069770at2"/>
    <dbReference type="Proteomes" id="UP000095558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO76477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO81241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="44" mass="5393" checksum="6A5C4F272D17F4ED" modified="2016-09-07" version="1">MFMTYQPKKRQRKKEHGFRKRMSTASGRTVLKRRRQKGRKKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTG9</accession>
    <name>A0A174HTG9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Butyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bcd</name>
        <name evidence="9" type="ORF">ERS852471_02243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266601.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76428">
        <property type="protein sequence ID" value="CUO76428"/>
        <property type="gene ID" value="ERS852471_02243"/>
    </dbReference>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="379" mass="41029" checksum="DE369173162EFDE4" modified="2016-09-07" version="1">MEFGLTKEQELVKQMVKNFALNEVKPIAAEVDETEKFPIDNVKKMGELGMMGIPFPKEYGGAGGDVLSYILTVEELSKVCATTGVIVSAHTSLSAGAINDFGTEEQKQKYLVPLAKGEKIGAFGLTEPGAGTDAAGQQTTAVLEGDHYVLNGSKIFITNGGVADIFVIFAMTDKKQGTRGISAFIVEKSFPGFSIGKVEEKLGIRGSSTTELIFENCIVPKENLLGKEGKGFGMAMKTLDGGRIGIAAQALGIAEGAYEEAIKYMKERKQFGRNLGAFQGLQWMIAEMDTKIEAARHLVYKAAWLKQNKLPYTVDAARAKLFAAEVAMEVTTKAVQIHGGYGYTKDYPVERMMRDAKITEIYEGTSEVQKMVISGAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HXZ4</accession>
    <name>A0A174HXZ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CxxH/CxxC protein, BA_5709 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79763">
        <property type="protein sequence ID" value="CUO79763"/>
        <property type="gene ID" value="ERS852471_02327"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2058657at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025626">
        <property type="entry name" value="YyzF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14116">
        <property type="entry name" value="YyzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04129">
        <property type="entry name" value="CxxH_BA5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO79763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="51" mass="6199" checksum="D92F1A845C1B53AB" modified="2016-09-07" version="1">MIKYVCEEHIDDIMDDLINEYETFPIMEECEDKQCEYCKNRSKYLVKITDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HY29</accession>
    <name>A0A174HY29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77725">
        <property type="protein sequence ID" value="CUO77725"/>
        <property type="gene ID" value="ERS852471_02282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO77725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="50" mass="5481" checksum="2EAA96D8AEC17ED3" modified="2016-09-07" version="1">MSKNANCGCNKAQKSAGNNQWASPASVQSSIYDNCKCNKKQEKTATNNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZE8</accession>
    <name>A0A174HZE8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiF domain protein</fullName>
            <ecNumber evidence="2">2.7.7.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeB</name>
        <name evidence="2" type="ORF">ERS852471_02290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.80" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78488">
        <property type="protein sequence ID" value="CUO78488"/>
        <property type="gene ID" value="ERS852471_02290"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1543144at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO78488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="25818" checksum="56C687B73598287E" modified="2016-09-07" version="1">MSLSPVCRTGLLIGNEGLDTLAKSKVIVFGVGGVGSFVVEALTRAGVGNLILVDNDTICISNLNRQIHATRNTVGMIKVEAMKERVLSINPDCKVEAKQVFLTADNLEEIIPSDVDYVVDAIDTVTSKLALAKYCYENNIKIMSSMGTGNKMDPSQFRVTDVFKTKVCPLAKVMRSELKKRGVKKLKVVYSEEMPMTPDKGDAVPSGKRQTPGSMPFVPPVAGMIIAGEVIKDLVGINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I0D5</accession>
    <name>A0A174I0D5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mtnN</name>
        <name evidence="7" type="ORF">ERS852471_02291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266683.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78525">
        <property type="protein sequence ID" value="CUO78525"/>
        <property type="gene ID" value="ERS852471_02291"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO78525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="24904" checksum="02F59F78C899EDFB" modified="2016-09-07" version="1">MVLGIIGAMSEELEILLKDMSLEDVQVKANMKFHKGMLWGKEVVAVVCGIGKVNAAICTQILASEYNVSAVINVGVAGGIGKDIYPGDVVIAENLVQYDMDTTAFGDPMGQIPRLDTFDFKCDAKLIETAKAACEEATDFKTFSGRIVSGDMFVASIDKIKWLEAEFGALACEMEGASIAHVCYLNKIPFVVIRSISDNANNGAHMDFEKFTPIGVKNSTFILKSMITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4F5</accession>
    <name>A0A174I4F5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266749.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79979">
        <property type="protein sequence ID" value="CUO79979"/>
        <property type="gene ID" value="ERS852471_02332"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2005506at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO79979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="15213" checksum="D8F35420ACB8293A" modified="2016-09-07" version="1">MIGFICAIISGISMTIQGVFNTRLNEKIGSWETTTIVQATGLALALIILCFFRKGDFGAIKEVNKLYLLGGFIGVVITYTVMVSIGSLGTTLGIGTILVAQLASAGLIDYFGLFGSERSSFGISQIIGVIVMIAGIVIFKWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I5T5</accession>
    <name>A0A174I5T5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80828">
        <property type="protein sequence ID" value="CUO80828"/>
        <property type="gene ID" value="ERS852471_02362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027981">
        <property type="entry name" value="DUF4446"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14584">
        <property type="entry name" value="DUF4446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO80828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="165" mass="18528" checksum="CDCD21BF6135C382" modified="2016-09-07" version="1">MSNILNIINEYSGLIVIGLAIITLLLLITTIVLLLSVNKVEKKYRKMMRGTNSRNLEEVINSNLDNIDVALNNSKESLERCEKIAEDLKSCVNKVAIMRYKAFEDVGSDLSFSIAILDSYNDGVIITGIYSRHDSTTYAKPIDKGISRYDLSEEELHVLNEAINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGF5</accession>
    <name>A0A174IGF5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MazG nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84039">
        <property type="protein sequence ID" value="CUO84039"/>
        <property type="gene ID" value="ERS852471_02432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10725" checksum="2BE5BA62512A4CEE" modified="2016-09-07" version="1">MNKTIERIRKFREDRDWSQFHTPENLAKAINIEAGELLEHFLWDNNFNKEEVCEELADVMVYCLHMADSLGVDIEDIINKKMDKNEKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IN49</accession>
    <name>A0A174IN49_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpmD</name>
        <name evidence="7" type="ORF">ERS852470_02562</name>
        <name evidence="8" type="ORF">ERS852471_02511</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834855</strain>
            <strain evidence="8 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZV01000028">
        <property type="protein sequence ID" value="CUO51307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005212077.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="84024.ERS852471_02511"/>
    <dbReference type="EnsemblBacteria" id="CUO51307">
        <property type="protein sequence ID" value="CUO51307"/>
        <property type="gene ID" value="ERS852470_02562"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87576">
        <property type="protein sequence ID" value="CUO87576"/>
        <property type="gene ID" value="ERS852471_02511"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000095558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO51307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO87576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="59" mass="6669" checksum="580C619C7816E53C" modified="2016-09-07" version="1">MAKIKVTLVKSLIGRKKDHIATANALGLRKINKTVEHEDTPQIRGMINKVDYLLKVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IZ98</accession>
    <name>A0A174IZ98_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267172.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90917">
        <property type="protein sequence ID" value="CUO90917"/>
        <property type="gene ID" value="ERS852471_02581"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2024391at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="18668" checksum="20A2F573EEA4CA4A" modified="2016-09-07" version="1">MNRQVYCEKCLEVIEEKEDLVILNGKPYHYNCYEKELKEEKKKTLMKRFVTWRFINSGLIANIQAVLVIALGVILYLFGGNFADEENCHIWGTIIIAIALIVRMYGFLSFEIKAKRVGRKSRILQSKDSVLQIVKIEAVDLLKVAGLVAFIAVVWNLISSVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IZS9</accession>
    <name>A0A174IZS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
            <ecNumber evidence="1">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267170.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90848">
        <property type="protein sequence ID" value="CUO90848"/>
        <property type="gene ID" value="ERS852471_02579"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO90848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="31278" checksum="E85447AB131F055A" modified="2016-09-07" version="1">MSKKVIFLDVDGTLVNDNGVVPESAKDAVRQARNNGHYVFLCTGRSKAEIYDEIMEIGFDGVIGAAGGYIEVNNEIILHKKVNREDVEHLVNYFDKNNIDFYLESNGGLFASKNCKKTLNKLVFEGVDKDSKLYKELEKGIGQFIEALIEGEDLIRDDINKISFLDSETSIETIRDEFKDKFNVIHCTVPMFGENSGELSVPGVHKALAIEYLIEHLGLSKETTFAYGDGINDMEMLQYVNYGIAMGNANEALKEIACDITGTHDEDGIYNSFKKYRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J1U9</accession>
    <name>A0A174J1U9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267285.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93732">
        <property type="protein sequence ID" value="CUO93732"/>
        <property type="gene ID" value="ERS852471_02646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO93732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="160" mass="18423" checksum="B4085E26BB79A49C" modified="2016-09-07" version="1">MSKKRHRKRQEVSSTNNSNNNNNRQQQMNYNNPFGINPNQLLSMFGNIDMNQINSMLQSMGADGFDFNNFNLGSLQNLMNGMGRSPAQQQGQQNSKQSQTNAQSNNRVDNQNQSFDDLKDLEYEDDNIQLLNSFRNIVGEEKKEFIDKIIKLYNDGAFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J253</accession>
    <name>A0A174J253_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267186.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91275">
        <property type="protein sequence ID" value="CUO91275"/>
        <property type="gene ID" value="ERS852471_02588"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO91275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24104" checksum="53073E29A5B9687B" modified="2016-09-07" version="1">MKKRKIYNVLILSMIILGSIAFCLFNPIDLSIENLKMIIKGSNIAYLIFLGIWIIRLIAFIPGVSLMLLGGLIFSPIEALILSLLGLVLSDTLVFILGKMDLFEGIKNKIKKKYKDIYKLVEEENHKILAIGVLCPVAPTDVICYLSSYLGLGYRRFIITFIIANIPAVSLYSFLGDSFSNSIYNTVFIIITLIVTSIITIKKWNKLKLNIHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBN5</accession>
    <name>A0A174JBN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose / sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267325.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94595">
        <property type="protein sequence ID" value="CUO94595"/>
        <property type="gene ID" value="ERS852471_02666"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO94595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="428" mass="48292" checksum="050352E742AB5993" modified="2016-09-07" version="1">MKRFLKFLVFSTLVVSISFGIYEINNKYTIDIINKNIGWSINNKGIKDAKSFDFDENGNLYIAFSDSLKIIKEDNKEETLIKKKDFNIYDMVIYKNEIILATGRDIVKYNYENDEILELIKDLPNLGENKYTKLLIEDDILYITIGTNTNSGILDKDSTDCDVPSFEWILSGENYGDNNTGAFVEYGIQNKSGEKVKEGIISNGTILSYDFTSGKISTFATGIRNIEGLDFNNEGKIIAIVGGMEDKGSRAVKDDKDYIYEIKENAWYGWPDYSGGDSITSPKFSDGTNKLEPVISNPPTKTPYGPIYQHYNLSSLKGLAVDREGNILGQDVIVFADNKENYLYSLGKNNVANKIVDLGDNSKVEVIRCYKDGIYVLDSKVGVLYKLESTGNKTIFKLPIIIWGFIIVFIIALIIAEVLKYNKKYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JEW6</accession>
    <name>A0A174JEW6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267423.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97201">
        <property type="protein sequence ID" value="CUO97201"/>
        <property type="gene ID" value="ERS852471_02719"/>
    </dbReference>
    <dbReference type="OrthoDB" id="754057at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO97201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="45019" checksum="D22F87A5192E8440" modified="2016-09-07" version="1">MIFFVTMIVFSPITSIIPGIYATYLMFKNKGKIEKNYLNIGLLVLFIWSLIVAIINESVLSFLGSSMLLMYFAIGFLGQRYFISIRRIHKTFKYSIYLTALTAINGIIEKGVYFYIFRKTGEFSNPFNDRVISAYGNPNMAGAWFASAIFIALYLRAITSGKKQKNIYTLCIAIILIALLLTESSGALVAFVAAFICYYVLKSLKDKRKMIILGLSIFTIISMFLILESKGDSKAVFNELRISFSSRYDIWTGSLKMIAQKPLMGWGTLATLEHGKEFFYNNGNSIHSHNIYLTFWVSTGLIGLCMYLYIKLKMFKDLFKLYKTKEPLVPLLVALNVIVIVQGLVDCSLYAPQLGILFMSTCAIVFNLSHGKLKVENKRKRKYKGNVIKLEAKTIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JJP4</accession>
    <name>A0A174JJP4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsU_2</name>
        <name evidence="4" type="synonym">rpsU</name>
        <name evidence="7" type="ORF">ERS852471_02724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267432.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97395">
        <property type="protein sequence ID" value="CUO97395"/>
        <property type="gene ID" value="ERS852471_02724"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO97395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="58" mass="6862" checksum="3C211090E8B14421" modified="2016-09-07" version="1">MSEIKVGENETLESALKRFKRKCARAGVLSEVRKREHYEKPSVKRKKKSEAARKRKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JKJ6</accession>
    <name>A0A174JKJ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prophage LambdaBa04, site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Int-Tn</name>
        <name evidence="8" type="ORF">ERS852471_02745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267468.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98158">
        <property type="protein sequence ID" value="CUO98158"/>
        <property type="gene ID" value="ERS852471_02745"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="168"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="390" mass="45633" checksum="AB7A541139EC2154" modified="2016-09-07" version="1">MQGHIRKHGKSYQYLFYIKLQNKYKCISKSGFSDKKSATKALRDAISKYEDYKYIDNNTIRFSEIAEEYIEYYAKTNLKLNTYIRYKSFYHKYLETTLGPIKINDINGMSINRTLNNAKYLNPEKPLTGSTLQGIYILINAIFNRALKQELVFKNPCKAADRPKRDAVNYSILTYDEINTIISLLDTTSHFDFLFAAGFIITLETGLRRGELAGLTWDNIDFDTKTLTVKNTLLYIQGHTVVQETPKTEHSMRDIYFSDNLKDIFLRLKSVYDKNLAILGGDFEEFVYKKKIYDFVFRHENGQHVHPMFFYNKLQRLMKESKIKKHIRWHDLRHSAASLQLMSGADITTISKRIGHYDPSFTLKVYSHIDMSQQKKVIDAFSSNLPKLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JL75</accession>
    <name>A0A174JL75_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267547.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00472">
        <property type="protein sequence ID" value="CUP00472"/>
        <property type="gene ID" value="ERS852471_02792"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025287" evidence="1">
        <location>
            <begin position="24"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="38"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="31688" checksum="B919E7C5B93AC697" modified="2016-09-07" version="1">MKFYKLLFLIFIILLYSCSNTSANSNSIMTVHFIDVGQGDAILVQVNDKNLLIDSGPKESSSIFFNYLNSINIKKLDYILASHPHEDHIGNMYSVIKRYDIGEFYAPKITHTSKSFEKMVESLISKNKKINVFDINTTSIDLGENVNIIIYSPLLKDYGDNLNLYSAVFKIEYGNTSFLFTGDAEKTNEEDILNSNTSIRSDVLKIAHHGSSSSTSTAFFNAVSPYITVISVGKDNNYNHPTSKTLNLLNSRSNKIYRTDIDNTIVLISDGNNIYKKFSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQ46</accession>
    <name>A0A174JQ46_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Virus attachment protein p12 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00286">
        <property type="protein sequence ID" value="CUP00286"/>
        <property type="gene ID" value="ERS852471_02788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="46" mass="5145" checksum="BDDF6BC7E653CA1A" modified="2016-09-07" version="1">MEIFITIVIVLIASFIIYKNIKKSSKGNCNCGSCSSHCSKYKNDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JVS5</accession>
    <name>A0A174JVS5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yebN_3</name>
        <name evidence="6" type="ORF">ERS852471_02811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267593.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01718">
        <property type="protein sequence ID" value="CUP01718"/>
        <property type="gene ID" value="ERS852471_02811"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1974730at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP01718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="21311" checksum="AB4F12E830CB4F92" modified="2016-09-07" version="1">MSLFEVIIVAIGLALDSFTVAVCRGSNQGNLKKSNAAIVGIIFGGIQTLMLIIGMLIAIFPMLNIENQKIISMNQWFSAIILFFLAFKSFKNAFVNTNIDERREEFFGYKGSVTLALATSLDALILGIGLGLLQTRFIRTIIIQFIITTLLVAYGLWVGYCVGNKYKKQIDICGGIILLSIGIKVILNYFQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K2L3</accession>
    <name>A0A174K2L3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP06262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267781.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06262">
        <property type="protein sequence ID" value="CUP06262"/>
        <property type="gene ID" value="ERS852471_02918"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2172499at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP06262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="112" mass="13551" checksum="2ABF8BE5A01737A6" modified="2016-09-07" version="1">MKIKIESLLIDKDNSIAERIGSDNAFWVRDLKFNVDPKSLEVTNEDPEILKCLKYYINENKNLIDYLEVRELIDTSNIICTNFWNEEEFNRTCKFEFRDYFNLEECKYVYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9Q8</accession>
    <name>A0A174K9Q8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267825.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07591">
        <property type="protein sequence ID" value="CUP07591"/>
        <property type="gene ID" value="ERS852471_02940"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909525at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP07591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="51" mass="6034" checksum="2CE1F14CD143F534" modified="2016-09-07" version="1">MTDKTLTCRDCGAEFVFTVGEQEFYKEKGFTNEPTRCIPCRRAKKEQNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KBD0</accession>
    <name>A0A174KBD0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding lysin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267805.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07088">
        <property type="protein sequence ID" value="CUP07088"/>
        <property type="gene ID" value="ERS852471_02928"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1522364at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025901" evidence="1">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP07088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="24744" checksum="758538D9FAD1733B" modified="2016-09-07" version="1">MKKLLINTLFSLFLLSLILSPTKVQALEDRESKDIPYNKATCELRMAERKLWIDYVLWTRSFIVSDLDSLEDKGPVLERLLKNQDDIGSSIKPYYGEEAGDKLATLLREHIELAGQVVDAAKNGKKDDLEKYNKLWYENADQIADFLSSANPNYSNQTLKDMLHKHLEFVTAQAVARLNGDWSSDIIAFDKGEDHMIMFADILVDGIIKQFPQKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KD58</accession>
    <name>A0A174KD58_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">sbcD</name>
        <name evidence="12" type="ORF">ERS852471_02984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267916.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09842">
        <property type="protein sequence ID" value="CUP09842"/>
        <property type="gene ID" value="ERS852471_02984"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="10">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="11">
        <location>
            <begin position="277"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP09842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="44820" checksum="51861C045C1DC967" modified="2016-09-07" version="1">MKIIHTGDWHIGKIVNEFSMIEDQKFYLDRLIELLEEERPDAFIIAGDIYDRSVPPAEAVELLDNVLSKIILELNIPVLAISGNHDSPERLSFGSKLLKDKGLYIEGTFKKEIRKVTIKDEFGNVNFYLLPFVDPAKVRLIYKNDEIRTYDDAMKFLVNELEKDINKDERNVLITHGYVTFNMEDKENKGDLELSDSERPLSIGGTDLIDGRNFDLFNYVALGHLHRPQKVGGNRIRYSGSLLKYSVSECEQNKSIPIITLDEKGEIEVELRKLQVLRDMRVVEGPLEKLIDRDTHKGENLNDYIFANLTDEGEVIDAISKLRAVFPNVMGLKMVNSREKNVDSKTSAGNNFRDKSESELFTDFYLSIKGKEMDQERIEVLNKVLEEIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQF1</accession>
    <name>A0A174KQF1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBA/TS-N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268049.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13021">
        <property type="protein sequence ID" value="CUP13021"/>
        <property type="gene ID" value="ERS852471_03054"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1760987at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="178" mass="20465" checksum="5C576089DEF563F3" modified="2016-09-07" version="1">MERNEMIEVLMGKANVSREEAQEVLEICNWDLLDAIIYLERRGKVENNETTTIIEVKEEEQEKKEDHKKHEEKFGGIGEVIGRMFKFLGKFIKKGNENFFEIRKANEKPIRISLTISLLLLIFLSVPTIVLLVVGLFCGYKYSISGPSMNYDGVNTVFEEVSKSADTIKKDFKEGYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KR58</accession>
    <name>A0A174KR58_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">recX</name>
        <name evidence="6" type="ORF">ERS852471_03080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268101.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14513">
        <property type="protein sequence ID" value="CUP14513"/>
        <property type="gene ID" value="ERS852471_03080"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP14513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="25159" checksum="E8608E065A76D8B3" modified="2016-09-07" version="1">MNIITKIEIGKRNKERVNIYIDDEFAFSLSAEIVYKENLAPKQVIDVEKLTRLAREDEFMKCKSSALKIVERSYKTEKEIFNKLITKEYSKESINRTIEFLREYNLINDRNYVKMYVKDKLKSQGKNKIKYNLKRKGISDELIIEELSKIDDEDSKNGAIILAQKKYNELKRRESDQYKLSQKLYRFLISKGYNYDLASDVMKEVIKKDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTT2</accession>
    <name>A0A174KTT2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268045.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12905">
        <property type="protein sequence ID" value="CUP12905"/>
        <property type="gene ID" value="ERS852471_03051"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2148067at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="232" mass="27274" checksum="EC7E43DEF3471E50" modified="2016-09-07" version="1">MKELSSGQKRILCFCGLGIMFIFMGNSNNSPEVFIRRIFKPISGENWVFYYSGFIVIGGIYYCLYKLNEIKENRLIRTPIRRFISTILLMSIFPMLWTNCTQVYKGFYKDLNAIYIDREISYMNFNKGNGTVSIDGRLYIKNCNNETQEFYIKIKTPSSIKSDIKEDYVTLPEKYIVHPKENKTIYVSQELLRTGESNNSTYMMKGFEYILFNDKDEAIFEGSVSDYKYDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZ14</accession>
    <name>A0A174KZ14_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="9">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisS</name>
        <name evidence="11" type="ORF">ERS852471_03113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268156.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15991">
        <property type="protein sequence ID" value="CUP15991"/>
        <property type="gene ID" value="ERS852471_03113"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP15991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="415" mass="47546" checksum="B9FB04E1C71FCAEA" modified="2016-09-07" version="1">MDIQAPKGTKDMLPQDAYKWQYVENTFKEIAKYYGMRELRTPMFEHTELFKRGVGDTTDIVQKEMYTFNDKGDRSITLKPEGTAPAVRAFIESRLFNEVQPTKLYYVTPCFRYENVQKGRFRQFHQFGTEIFGSKEPSMDAEVIAFAMNVLKKLGLSSLSLNINNLGCPSCRPKYNEALKQYLKENYDNLCDLCKSRFEKNPMRILDCKNHKCNEITKNAPIILDFMCDECDTHFTKVKEYLDALSIPYKVDPGIVRGLDYYTKTIFEILNDDFTVCGGGRYDKLIEQLGGPEMPAVGFGMGVERLIMILEKEGIEIPNEILFDLYIGARGEEAKLAAFTLANKLREVGIKTEVNHMGRSIKAEMKYANKIGAAFTTILGDDELQNKVIKLKRMSDGEQFEVSLDHIEEIVNVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZN7</accession>
    <name>A0A174KZN7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_03105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15637">
        <property type="protein sequence ID" value="CUP15637"/>
        <property type="gene ID" value="ERS852471_03105"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026589" description="Carbonic anhydrase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP15637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="26330" checksum="482F5B5BF93AD351" modified="2016-09-07" version="1">MNKAFIAMLLATSIIFAGCTSKGVNDGSNTSNNTSTSQSENKTNDSSIGENVNVDTKVTTAEEAMKLLEDGNARFLSDKSELRNIDSARRNELKDGQNPYAVIVSCSDSRVTPTTIFNAGLGEIFDIRIAGNIVDDDALGSIEYGAEHLHSPLIVVIGHQSCGAVTATYNSVVKGEKATGHIEDIVEKIEPNVNSNGTIDDAIRANIDSVVKEISEDEIIKNLISEGKVKVVGAYYDLNGKVTFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L5A2</accession>
    <name>A0A174L5A2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18031">
        <property type="protein sequence ID" value="CUP18031"/>
        <property type="gene ID" value="ERS852471_03148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="12789" checksum="3FF79B39C24C2C3C" modified="2016-09-07" version="1">MFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAERVNYIFEVLGLSLFECYDMTEKFYKEVKKIATEINNFLNEGNSDERKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L8W3</accession>
    <name>A0A174L8W3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18215">
        <property type="protein sequence ID" value="CUP18215"/>
        <property type="gene ID" value="ERS852471_03152"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035983at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="146" mass="16276" checksum="947D9167E8A2E2BF" modified="2016-09-07" version="1">MTILIDKPVLSKAAESAMGTFDREQLEEIHMLIEDSSFDRISQKAKIDIFVDEPDEEESEPEYEEPEYYEPAPRKTGLGFFGTLIAILAAFGSAGGSKKKGHNDRCNGDCANCPPHYGYRYGRWYYGHDHVHGCEFGGNKGSGSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M2D3</accession>
    <name>A0A174M2D3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Signal peptidase (SPase) II</fullName>
            <ecNumber evidence="7">3.4.23.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_03318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000044">
        <property type="protein sequence ID" value="CUP27959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268502.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27959">
        <property type="protein sequence ID" value="CUP27959"/>
        <property type="gene ID" value="ERS852471_03318"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272788at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP27959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="30050" checksum="422A7CA1312C2E70" modified="2016-09-07" version="1">MKNIYNKDKLLTIGILPIMWLIYFAFEIVTGRVKDLYTLILNLSLVFVFAFVGYIIYYLSNKYSDGFKSKKLFIIFIILMLIDQGSKLIIKFNFFDSYYEIIPRFLSFDPIINTHGSWLNARFNFNISFPLLILINFIALFIFFEFYRYIKFKSGKNTFWGDMCFVFIFAGALCSLIDKVFYGGSLDFIGISDLFIADIKDIYINLGLLFFIMATYKSDFLKDDGNSSLKDDWQAIKNFLVFIKNDIKRSIKKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XH17</accession>
    <name>A0A173XH17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">[Ni/Fe] hydrogenase, small subunit</fullName>
            <ecNumber evidence="11">1.12.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hupS</name>
        <name evidence="11" type="ORF">ERS852471_00039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.2.1" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50913">
        <property type="protein sequence ID" value="CUN50913"/>
        <property type="gene ID" value="ERS852471_00039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047806">
        <property type="term" value="F:cytochrome-c3 hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00391">
        <property type="entry name" value="hydA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="9">
        <location>
            <begin position="63"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="10">
        <location>
            <begin position="229"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN50913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="315" mass="34477" checksum="30BF5D3AC09A923A" modified="2016-09-07" version="1">MLIFTQSDYIIPVTYVDKEKLGVKSSGIRGRESAFNMAKRAIEAVKSGERKKMNAIWLETSGCFGEAISLLNAEDPDVLYMLKEFLNIKYFESIQGDEDQEALEELFSILKSEFVLIVDGAVPLAGDGLFTIIGTYNVRKITAKEAVNFLASKAKYIVSVGTCACYGGPTAAKPNLSEAVGVSEFLERNDVIKIPGCPANPVWTMGVLGHLVNYGVPELDKEGRPLAYYGELIHDRCPRRRFFDAGIFAKTFGGEECMFLLGCRGPVTYAYCPVSRWNDSENWPIGDNTTCIGCAAPGFPDSMEPFVKYGGGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XN39</accession>
    <name>A0A173XN39_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pcrA_1</name>
        <name evidence="7" type="ORF">ERS852471_00074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262784.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52983">
        <property type="protein sequence ID" value="CUN52983"/>
        <property type="gene ID" value="ERS852471_00074"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="5">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD_C_2" evidence="6">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN52983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="585" mass="67567" checksum="868089F548E0D4A4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQM4</accession>
    <name>A0A173XQM4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acid sugar phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagD</name>
        <name evidence="3" type="ORF">ERS852471_00097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. NagD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262825.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53989">
        <property type="protein sequence ID" value="CUN53989"/>
        <property type="gene ID" value="ERS852471_00097"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN53989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="29962" checksum="172C32983DD2FDC9" modified="2016-09-07" version="1">MRAITDIQCFVLDMDGTIYLGNEIIDGAIEFINTIKSTGREYIFLTNNSSKNRQVYKEKLNRLGIDVEEEKIFTSGEATTIYLNSLKPNSKIFLLGTNYLEEEFINAGFNITDKYEDDIDFVVLGFDTTLTYNKLWIACDLIRDGVTYIATHPDKNCPLEGGKFMPDTGSIIELIYASTGKRPYVIGKPNPEIIDLICMKYDVSKESIAMVGDRLYTDIQTGKNASISSVLVLSGETNLEEYYNSNIKADYVYESVKEINEELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XU02</accession>
    <name>A0A173XU02_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/phosphate cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262841.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54407">
        <property type="protein sequence ID" value="CUN54407"/>
        <property type="gene ID" value="ERS852471_00106"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1341748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="347"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="453"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN54407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="540" mass="58599" checksum="9E8E894B26F494D1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXH8</accession>
    <name>A0A173XXH8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimP</name>
        <name evidence="6" type="ORF">ERS852471_00154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262928.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56762">
        <property type="protein sequence ID" value="CUN56762"/>
        <property type="gene ID" value="ERS852471_00154"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN56762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="17815" checksum="142509790B8A4B35" modified="2016-09-07" version="1">MKVESLIKEIYGIVEPMAKELNLEIYHIEYVKENGEYYLRIYIDKDGGIFLSDCEALSRRVSDVLDEVDPIKEAYFLEVSSPGLNRRLFTNDHYVKFVGREVLVRLTKALDGNKNFKGTLKEVNEDNIVIQLEDEKLQTIPKDKIKSTNLEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XYE9</accession>
    <name>A0A173XYE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262891.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55625">
        <property type="protein sequence ID" value="CUN55625"/>
        <property type="gene ID" value="ERS852471_00132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN55625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="13815" checksum="383D4F0DA04354D6" modified="2016-09-07" version="1">MYDNIGINKEKRLNYMKKRIRIPKITNRNYYIYSYDYDNNCCEDNDFEDAYKDYYENEYDYENDEYKENYPCDAFCEDYEETCKCTMNTVKKLALVSAGVLVGVSAISLLLSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y475</accession>
    <name>A0A173Y475_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57987">
        <property type="protein sequence ID" value="CUN57987"/>
        <property type="gene ID" value="ERS852471_00179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="317" mass="36129" checksum="9556A0E7B622979C" modified="2016-09-07" version="1">MLGAKSLIGLTDLLIYLDEELTKNLNSLVIKGYIEKRTSRWIEDRTISGNIRFQDREQYFEEDRCIRDERDGYKGKNYNSADSLTNTKEKAEGLDGRRFIRREEELTRIYTVFELHNQLVNGLNDSNILKNVSDEWMSDDISVGDYIQLNGVIGEDSILSYVDVCCNLINCIGCDTLNSLAKSTSSNIYNYNVLSSSLITLRDYLNVNNTQDVIINTNNNDVVVMMNNQYLFNNYGNIYERAGCPCKIIGKVIRVCEEGEYIHLLRKTGQPEFYEKLLASHSILNNSLKSNGLIIPTEPRVKVEGKTLLVVPISMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y649</accession>
    <name>A0A173Y649_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">spoIIIE</name>
        <name evidence="12" type="ORF">ERS852471_00209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263031.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59602">
        <property type="protein sequence ID" value="CUN59602"/>
        <property type="gene ID" value="ERS852471_00209"/>
    </dbReference>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="11">
        <location>
            <begin position="447"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="464"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN59602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="785" mass="87968" checksum="F6FF5510DB152857" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YDA6</accession>
    <name>A0A173YDA6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263083.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61217">
        <property type="protein sequence ID" value="CUN61217"/>
        <property type="gene ID" value="ERS852471_00237"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1982036at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024232">
        <property type="entry name" value="SpoIIIAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038503">
        <property type="entry name" value="SpoIIIAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12685">
        <property type="entry name" value="SpoIIIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="25318" checksum="85BA119707C1FA19" modified="2016-09-07" version="1">MSENKIICPECGKENTEGSIICSGCKKVLQNDLAQARIDKVYPKYNFKNIKTGFRTQVKNRKPSVIVGAILCISIIGTVIYTTGRSTDESASSLSADLSAMILENDNAEETMSNQGFFYNDRANKIKADTDFKEEMNSIIEDTNSSQEVIDNATNLLNEKVKIQEQETAVESEIINNGYEDALCMIDKNIVRVYVKTNDVFTEENATSIQNIVEGITGLSDIQIESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQU5</accession>
    <name>A0A173YQU5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT</name>
        <name evidence="3" type="ORF">ERS852471_00282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263185.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65445">
        <property type="protein sequence ID" value="CUN65445"/>
        <property type="gene ID" value="ERS852471_00282"/>
    </dbReference>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN65445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="351" mass="38974" checksum="63CD224989FC52A0" modified="2016-09-07" version="1">MYFLKELLVNTLELGASDLHLTVAVPPTVRKNGKLIKIGNENLLPEDIEKFAREILEEKYEEYLEIGEYDISYSLTGVGRFRANIFKQRNSDAIAIRVIALKIPTLDELKYPSVLKDISNKQRGLILVTGPTGSGKSTTLAAMINEINSSRQGHIITLEDPIEYLHKHKSCIINQREIGKDSKSYKNALKAILREDPDVILVGEMRDLETISIAITAAETGHLVLSTLHTIGSAKTIDRIIDVFPPYQQQQVKVQLASVLQAVVSQQLIEKADGSGRTAALEVMVTTPGIQNLIREGKTHQIESAVQTGSKYGMKTMDMALADLYKRGEITSESAISYAVDRETLKRLMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXU9</accession>
    <name>A0A173YXU9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">plsX</name>
        <name evidence="5" type="ORF">ERS852471_00333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263281.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68309">
        <property type="protein sequence ID" value="CUN68309"/>
        <property type="gene ID" value="ERS852471_00333"/>
    </dbReference>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN68309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="36057" checksum="B99E2193F97BCE4F" modified="2016-09-07" version="1">MKIAIDGMGGDHAPKAVVEGVVKATEEFKDIEFFITGPEEQIKEELQKCNYIGDRIKIVNATEVITNNEHPVMAIRKKKDSSICKALNLVKDKECDAVISAGSTGAFLAGCTFVVGRIKGIKRPALAPIMPGKNGPFMIVDCGANVDCKPEHLINFAYMGKEYYKGVMGNNNPKVGLVNIGAEAEKGNELTKATYSLLEQEDGLNFVGNVEPRYISDGDTQVLVCDGFVGNTVLKMYEGTASNLLNIIKEEILSTGIKSKIGAVLLKPVFSNIKKKFDYKEYGGAPFLGVDGICIKAHGSSDAKAFKSAIRQTKNFYDSKVLDKIKEGLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z9Q9</accession>
    <name>A0A173Z9Q9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HypQ3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72389">
        <property type="protein sequence ID" value="CUN72389"/>
        <property type="gene ID" value="ERS852471_00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016715" evidence="2">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="14615" checksum="D6FB97F94E59DBB2" modified="2016-09-07" version="1">MKKHFSKSINFLLITLLVVGLFVGCGNKTTNDTTNNKPQTENSTNNTTNNSTTDNKESSNSGNEKTFTLDELSKYDGTNGQPAYIAVDGVVYDVTSNFPNGEHHGCKAGTDSTESIKKISHGSAILSNSPVVGKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD57</accession>
    <name>A0A173ZD57_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
            <ecNumber evidence="3">1.2.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cutS</name>
        <name evidence="3" type="ORF">ERS852471_00447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.99.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263481.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74312">
        <property type="protein sequence ID" value="CUN74312"/>
        <property type="gene ID" value="ERS852471_00447"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN74312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="16751" checksum="7057F827E9ED5F41" modified="2016-09-07" version="1">MKIKVWINNKVFEDDIEPDTLLIDFVRNKGFLSVKRGCDTANCGLCTVHLEGKPVLSCSTLAMRANGLKVTTIEGLEEEAKEFAQFMADQGAEQCGFCSPGFVMNVLAMKKELINPSDEEIKLYLAGNLCRCTGYMGQLRAIKNYLGLTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZG23</accession>
    <name>A0A173ZG23_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoVK</name>
        <name evidence="3" type="ORF">ERS852471_00454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263565.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74713">
        <property type="protein sequence ID" value="CUN74713"/>
        <property type="gene ID" value="ERS852471_00454"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="358"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="626"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN74713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1121" mass="129316" checksum="69CCE5A2B29092FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZS4</accession>
    <name>A0A173ZZS4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81527">
        <property type="protein sequence ID" value="CUN81527"/>
        <property type="gene ID" value="ERS852471_00526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN81527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="48" mass="5517" checksum="1ADCD534FFA6212F" modified="2016-09-07" version="1">MECTYAQIDLNSYVAKYVDEMGCSLEEACRELGIDLSKVFNSEEKNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZY1</accession>
    <name>A0A173ZZY1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagenase-like protease</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbU_2</name>
        <name evidence="2" type="ORF">ERS852471_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263647.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81881">
        <property type="protein sequence ID" value="CUN81881"/>
        <property type="gene ID" value="ERS852471_00530"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="324"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="410" mass="46841" checksum="43F651FB670A2C90" modified="2016-09-07" version="1">MTKYKKPELLAPAGSLEKLKIAFQYGADAVYFGGQSFSLRAAAQNFSYEEMAEGVKIAREYGKKMYCTVNIMPRNSDLEKLAEHLKKLEEVGIDAVLVSDLGVFSLVQKYTKLPIHISTQANTVNYEACNMWHKMGAERVVLGRECSLKDIIEVRENIPEDLELEVFVHGAMCISYSGRCLLSSYMAGRDSNRGACAQSCRWKYSLVEEKRPNEYFPIEEDQYGTYIMNSKDLCMIEHIPELMKAGISSLKIEGRNKSEYYVAIVVSAYRKAIDLYFEDPENYKLPKYLLDEMYKVAHRRYHTGFFFNEPMEEGLIFDTNNHVREYDVVALVLDYDKETGLATCRQRNKFVKGDIVEILSPEITGESFTVDVLFNEAGEEIDGCPHPGMICKVKVPFELEKNSFIRKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6H1</accession>
    <name>A0A174A6H1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">arlR_1</name>
        <name evidence="11" type="ORF">ERS852471_00561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263701.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84231">
        <property type="protein sequence ID" value="CUN84231"/>
        <property type="gene ID" value="ERS852471_00561"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="26390" checksum="6BBE0D5C0F6CD7FD" modified="2016-09-07" version="1">MIKVLLVEDNEKISENILEYFKDEMDIKNVYNGRDAIDYLELYDFDIIILDLMLPEIDGMGVLKYMSKKGIDTAVIVLTAKEELGDKLKAFNLGANDYLTKPFYMEELKARIIAILKSVGKIKSSNMLQFKDMEVNMKTKRVYIKGNEIDLNEKLYSLLEYLIMNKGVLLFKEQIFDNICGYNSDASTEIIEVYMSRLRKNLSKYGYDKYIVTKRGMGYLMDESIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9A7</accession>
    <name>A0A174A9A7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component sensor histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">graS_3</name>
        <name evidence="6" type="ORF">ERS852471_00575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263727.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85242">
        <property type="protein sequence ID" value="CUN85242"/>
        <property type="gene ID" value="ERS852471_00575"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="126"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN85242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="39125" checksum="BF95FE984DA28CAE" modified="2016-09-07" version="1">MNIVEYIKERIPFLIINLVLFFIVAIFMYIANVPKSIIIIVFSIWFLPLVSYIVIELIKSKRYFDSINNVLENLDKKYLLPEVIDEANFIEGKILNNILKTLSKDMNERVKYFKDEQLEYREYIETWVHEIKTPISSTKLILENDDSKLSERVNYEIRKVENYIDQVLYYARSSDVSKDYIIKEFDLRAVVMKSIKSNSRDFINKKIKLELKEVSGKIFSDAKWIEFIINQVIVNAIKFSEANKGVVEIYSEEYENNIVLTIKDNGVGISDKDIDRVFEKGFTGENGRRFGKSTGIGLYLCKNLCRKLGLGITITSKVNEGTKVNIVFPKGRFTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACU5</accession>
    <name>A0A174ACU5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadR_1</name>
        <name evidence="3" type="ORF">ERS852471_00587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263751.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86234">
        <property type="protein sequence ID" value="CUN86234"/>
        <property type="gene ID" value="ERS852471_00587"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN86234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="24039" checksum="F64E30BDD641CBAD" modified="2016-09-07" version="1">MSDKELQNAEVKDKIIKAAIEEFAENGYKAASTNSICKKAKVSKGLIYYYFKSKEEIYLHALKFAIDRFKENVNIEIDDKDKCGIDYISRYFDIKFKFFRENPLYSMLIVNSVLYYNIEEAIKLSEEFQEYNNNLIYKIIKNIDINPKFDREKAFELIMIIGEKLEEKHMRNIGDKDKDTVIEEFRKDHKIMIEMVFEGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AF18</accession>
    <name>A0A174AF18_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adhR_2</name>
        <name evidence="2" type="ORF">ERS852471_00602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263779.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87192">
        <property type="protein sequence ID" value="CUN87192"/>
        <property type="gene ID" value="ERS852471_00602"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="132" mass="15458" checksum="7E8D90127DAB396E" modified="2016-09-07" version="1">MYTMKEVSKQVGISYETLKYYCKEGLVPNVKRDKNNYRIFDEKNVAWLKGLQCLKKCGMSIKDMKLYMNYCLQGPSTIPERKEMLNKSKEALLNQIKEINECINFIDNKQAFYDGVLTGKIEYESNLIDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJC8</accession>
    <name>A0A174AJC8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_2</name>
        <name evidence="6" type="ORF">ERS852471_00613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263801.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88009">
        <property type="protein sequence ID" value="CUN88009"/>
        <property type="gene ID" value="ERS852471_00613"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="445" mass="47924" checksum="2F82B86E056A47D9" modified="2016-09-07" version="1">MDLTLGKESIGKLFVKYSIPSVIAMIVFSLYIVIDGIFVGNVVGAAGLSAVNLAMPFFGVAMALGTMVAIGGGTITSIDLGRGDKEEARRSFSLAFYILTAITLALSVFTLAFTPTIARILGSSEELMPLVIEYLRALCLFLATFVGSSYLSANLRVMGKPNHAMVADIIGAALNIVLDYIFIVKFGWGLAGAGVASGLAFTIGFIFSLVQYLRKDSILKFVKTSFDIKKVIKIFYNGSSEGITQFAVAFSNYIFNIVLMIKIGEMGVSAFSIILYISSLVTAVFSGICNGISPIISFNHGAKNKDRIQKLMKISVITISIIGVLSTILMAFGGETLIAMFTEGDDSLVSLTVEATRVYSIAFIVNGLNILSSAYFTAIEDAKTSAIISALRGAILIVIFIVLLPMIFGDVGIWLTVPFSEVFTVVVAFRYIRKSNRKLTLMYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKQ4</accession>
    <name>A0A174AKQ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate/sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pitA</name>
        <name evidence="7" type="ORF">ERS852471_00630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263834.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88987">
        <property type="protein sequence ID" value="CUN88987"/>
        <property type="gene ID" value="ERS852471_00630"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN88987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="350" mass="37256" checksum="1D3EA15A1D25A764" modified="2016-09-07" version="1">MTISLAEFIYELTHNLPLLITVILTLGVIMVNGWTDAPNAIATCVSTRAITPRAAIMMAAVFNFLGVFIMTIINANVAETIYNMVDFGGDPAESLVALCAALFAIVLWATAAWYFGIPTSESHALIAGISGAAIALQGGLKGINGGEWIKVIYGLILSTILGFLLGWITVKIVEFLFKGFDRRKTSEFFQDAQVVGGAAMAFMHGAQDGQKFMGVFMLGMFLAKGKSDVSNFVIPVWLMVLSSAVMALGTSIGGYKIIKAVGMDMVKLEKYQGFSADLAGAGCLLISSVVGMPVSTTHTKTTAIMGVGAAKRLSSVNWGVVKEMVLTWVLTFPGCGVIGFLMAKLFIQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMP0</accession>
    <name>A0A174AMP0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiA</name>
        <name evidence="3" type="ORF">ERS852471_00644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263854.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89697">
        <property type="protein sequence ID" value="CUN89697"/>
        <property type="gene ID" value="ERS852471_00644"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681738at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="224" mass="24657" checksum="0AD035C166B639C7" modified="2016-09-07" version="1">MKRRCAKEALNYIKDNMTIGLGGGSTIGYLISYIKESGLNVKVVTPSFKTASLCIENSIQVLPTWSISSVDIAFDGCDEVDEELNALKSGGGIHTKEKIIASMAKEYVLLVDESKVVKRLEFNHPVVLEIIPESKSYVESVIRNLGGIPKMRSSVAKDGITISDNGLFLIDAFFDKYKISSIEKLNEDLNSIVGVVDTSLFYKIATKVIVVSDTEIKIIEREVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B283</accession>
    <name>A0A174B283_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN93856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263942.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93856">
        <property type="protein sequence ID" value="CUN93856"/>
        <property type="gene ID" value="ERS852471_00681"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1917919at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019635">
        <property type="entry name" value="DUF2500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10694">
        <property type="entry name" value="DUF2500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="14408" checksum="A4F0CAB8B4D16AF7" modified="2016-09-07" version="1">MFEMGMFNIMSFIFPIFFIVFFAMFIFIIVSNIKEWSNNNKQPIIPVASTIISKRINVSHHHHGETHTTSRSTTYYTTFQFDNGERLELKVSGKEYGLMAEGDKGILSFQGTRFISFERENRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B536</accession>
    <name>A0A174B536_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspC_2</name>
        <name evidence="4" type="ORF">ERS852471_00703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95319">
        <property type="protein sequence ID" value="CUN95319"/>
        <property type="gene ID" value="ERS852471_00703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022518">
        <property type="entry name" value="Aspartate_4-decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03801">
        <property type="entry name" value="asp_4_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="186"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN95319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="543" mass="61675" checksum="B29E53FDE4B9142B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BA61</accession>
    <name>A0A174BA61_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yebN_1</name>
        <name evidence="6" type="ORF">ERS852471_00749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264061.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97902">
        <property type="protein sequence ID" value="CUN97902"/>
        <property type="gene ID" value="ERS852471_00749"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1857762at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN97902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="20637" checksum="E7916CC3E88DA11A" modified="2016-09-07" version="1">MDLRHLIIIGIALAMDALGVTLSIGLNPRVRRDSKIKYIISFGFFQFLFFFLGGVFGYLFEKYVVAIPNIIGGIAIGIVGIMMFKEGFESEEKDDELLLKKGMPIILGISVSIDALVVGFTASHRACICLLMVLNAVMIGLITLLICTTGFFLCRYIRRLDFVTRYADFLGGIILIIFAIKMIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BEU6</accession>
    <name>A0A174BEU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99267">
        <property type="protein sequence ID" value="CUN99267"/>
        <property type="gene ID" value="ERS852471_00774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="32470" checksum="A0E00C722886E2BA" modified="2016-09-07" version="1">MNKIILMTDSCCDLPYDFTEDNNLVVIPLMLTLGDRTIADDLGKTLKYEDFYKAVRSGEMPKTAQANVYEFEQEFEKYIKNGDKIIYIGFSSALSGTYNSANVAMESLKEKYSDADISVIDSKSASMGLGLLVYYANKMIKEGKSKDEIVKWVEENKLKVVHWFTVEDLNYLYRGGRVSKATATVGSLLSIKPVMHVDNEGRLTPVEKARGRKKSLSALANKLIEEIVNPEEQIVFISHGDCIEDVEYVKEKILEKVKVKEIVVNHVGPVIGSHSGPGTVAIFYFAKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGI2</accession>
    <name>A0A174BGI2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate:ferredoxin (Flavodoxin) oxidoreductase</fullName>
            <ecNumber evidence="14">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nifJ</name>
        <name evidence="14" type="ORF">ERS852471_00766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.1" evidence="14"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264091.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98860">
        <property type="protein sequence ID" value="CUN98860"/>
        <property type="gene ID" value="ERS852471_00766"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10483at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="966"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="820"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="843"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1075"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN98860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1173" mass="128206" checksum="4F34E01123C0A50C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHQ9</accession>
    <name>A0A174BHQ9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppaC</name>
        <name evidence="10" type="ORF">ERS852471_00772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264101.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99156">
        <property type="protein sequence ID" value="CUN99156"/>
        <property type="gene ID" value="ERS852471_00772"/>
    </dbReference>
    <dbReference type="OrthoDB" id="732679at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN99156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="546" mass="60407" checksum="7A905AB4EF2BFF95" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRG1</accession>
    <name>A0A174BRG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trxA_3</name>
        <name evidence="2" type="ORF">ERS852471_00841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02779">
        <property type="protein sequence ID" value="CUO02779"/>
        <property type="gene ID" value="ERS852471_00841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="107" mass="12468" checksum="1481A214E5541B8A" modified="2016-09-07" version="1">MINIENPKEVEEVIENNKMSIIYFTGSACGACEVIKEKLESILNEFPKIECREVNGEKHIDLAAKYGIFSLPIMLLFIEGKEFLRVGRNVNLLELKNNFERYYNMIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3W0</accession>
    <name>A0A174C3W0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family protein</fullName>
            <ecNumber evidence="2">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">celE</name>
        <name evidence="2" type="ORF">ERS852471_00917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08221">
        <property type="protein sequence ID" value="CUO08221"/>
        <property type="gene ID" value="ERS852471_00917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040794">
        <property type="entry name" value="CE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17996">
        <property type="entry name" value="CE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CE2_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="360" mass="40708" checksum="71EC9DFC60D3EE67" modified="2016-09-07" version="1">MRLENLDKDKYALIEADNPNYQYMGRVDFENPKAPTIIYAGSTIRTKFTGTSLKIAINNNGGGYESAIGFIIDGNITGKVVIEEHGKDIILNVAEGLKEGIHDLVLYKRASACHYFDFYGVILDKWCCIKAPEEKSNRRIECFGDSVSAGEVSEALDYVGKVDPEGHEGTLSNSWYSYSMMTARNLGAEINNIAQGGIAVMNGTGYFNPDRGYLGLESTYDKLRYNPELGYCNEWDFSNYIPHVVIMALGQNDAHPYDYIDEDKEKRELWKAKYKNIILDLRSKYPEALFVIITTILCHNKGWDDALDEMTNDINDEKIVRFKFKRNGLGTPGHIRIPEAEEMANELTSFIKSFGDDIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCE1</accession>
    <name>A0A174CCE1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cggR</name>
        <name evidence="3" type="ORF">ERS852471_00939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264441.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09358">
        <property type="protein sequence ID" value="CUO09358"/>
        <property type="gene ID" value="ERS852471_00939"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1390156at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="90"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO09358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="38298" checksum="79FA3010E679F4B8" modified="2016-09-07" version="1">MQEILSLQKKIVPELVEVLEKRYNILRTIYYNQPIGRRVLASELNLGERIVRTEISFLKSQGLIEVNTPGMSVTEDGKVIVKRLKEFIHELKGLADVEECLRSCLGLKDVIIVPGDVDSNPTVLKDLGKAAATYVKKILKDNNIIAITGGSTIKEVVEAFPKINNVSNVLVVPARGGMGRKVESQANTLAASLAKKINASYKLLHIPENVSAEVLDGLLKESQVKDVIESIQKADILIYGIGNAIHMAKKREASDEFIKKLEDMGAIGEAYGCYFNKDCQMISENNSIGINLNNAKKIRTHIAVAAGKNKIDAIIATEMYNRNAVLVTDENTGKEICEIIKSNNLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDY4</accession>
    <name>A0A174CDY4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11067">
        <property type="protein sequence ID" value="CUO11067"/>
        <property type="gene ID" value="ERS852471_00974"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24459" checksum="EF852EE8D2DDF414" modified="2016-09-07" version="1">MAKLIKVQKPKFIDDFEEIEDIYDEVIYEEKIQNKIIEDRDIREKNDVGITIDSCIFRNVAFEDCDFTRIDLLDSRFENCDLSNVSFSGGGLHRVEFVNCKLMGANFSECSIKDATFQNVMGGYATFSFSKIKNVNFIESNLKEAVFQEVKLDKVVFEECDLTNGYFNKTFLGKQDFTSCDIEGIDVDIENIYGATVTAMQGLDLTRLMGLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHP4</accession>
    <name>A0A174CHP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysL</name>
        <name evidence="3" type="ORF">ERS852471_00982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264515.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11460">
        <property type="protein sequence ID" value="CUO11460"/>
        <property type="gene ID" value="ERS852471_00982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="33631" checksum="EA0B44F7D7C4962F" modified="2016-09-07" version="1">MNIEKLKSFCKVVEYDSFSKASEELFCSQPAISKQIKSLEKEIGFSLFDRDGKKITLNSNGQIVYKYAQRILDEIAEMNREIIEINSSLSPVISFGATNFIGVHIITPKISRFKEANAEASLSFTIDFIPNILKMLQFNKFSFAFISESNLLNDYPDIETEFFRDDELILAVPYNHPWAKRQYINLDELKNETFLVSQPNSAVRNFIEKQLYSKGIVLTNINNLYNIEGIKQSILSGHGISIIPKEAIITELNHKLLVEVPIKDLTFTRKLFIAYKKNKRFTSMERNFIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CX51</accession>
    <name>A0A174CX51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO17753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264605.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17753">
        <property type="protein sequence ID" value="CUO17753"/>
        <property type="gene ID" value="ERS852471_01080"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1674734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="31309" checksum="1A408A23ADD80AEE" modified="2016-09-07" version="1">MNNNLKFILKATGIHILTYILCGIIFSVVFNYNSLFTMDGVNGFMREVGGLSTLLGPLVQVIRGILFGAVLLLFKDTFIGKKYGWLKLWAILSIIGIINTPGPAPFSIEGIVYTKLPLEFHLKGAPEILIQTLLFSYLLAKPSKKKKIKLIEENKHEFVSTIVCMVLFSLSGIVLALIRGISIESSIGDIGAFGVMFIAVISTFFISKYYPKMKSKFKDIIVIASLYFLLAILPYLYNLITNSPFNTWLTLLVNIIPTGVLWFIIKSNYKINKQFNKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0E8</accession>
    <name>A0A174D0E8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264623.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19014">
        <property type="protein sequence ID" value="CUO19014"/>
        <property type="gene ID" value="ERS852471_01103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1987646at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="17147" checksum="37057A6A68C8CA13" modified="2016-09-07" version="1">MRKEEIQKEILFKISQYAKSVDETDLNLASKVWMDSDESTFIHPRGHEHGFEQIKENFYIKTMRNNFSKRNLNIFDVNMQIFKDTVIAEFYWHFVAQFKNTKESHETKGRETQVYIKTEDNKWRLFHVHYSNMPVTGEKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2N9</accession>
    <name>A0A174D2N9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat associated protein JA (CotJA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18320">
        <property type="protein sequence ID" value="CUO18320"/>
        <property type="gene ID" value="ERS852471_01089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020256">
        <property type="entry name" value="Spore_coat_CotJA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11007">
        <property type="entry name" value="CotJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO18320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6259" checksum="83BB101F4F307F41" modified="2016-09-07" version="1">MKIKDPNLTNNEYAKACIALQKYENLLSTTEAFKLGTIFRDLRSSYEETETVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D794</accession>
    <name>A0A174D794_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine kinase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264664.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21107">
        <property type="protein sequence ID" value="CUO21107"/>
        <property type="gene ID" value="ERS852471_01146"/>
    </dbReference>
    <dbReference type="OrthoDB" id="997658at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="187" mass="21781" checksum="D8986225D01913BC" modified="2016-09-07" version="1">MRIYIELESCKLLGSGAEGSVYLSPEGYVLKSFKSKKAADKEAFILNCAKNSRFFPNVILQVSTLIIRDYVGGENLYEYLSVHGLSYKVSTEIIDFIEDLKILKFKRLNIRNAHIFINEKEELMVIDPRKSFSKNTPYPKDIVKIFLKLHLFDKFLEDLTSYKPDLLSYWIDAYEYTAKFNKVSRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIZ2</accession>
    <name>A0A174DIZ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264733.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25521">
        <property type="protein sequence ID" value="CUO25521"/>
        <property type="gene ID" value="ERS852471_01214"/>
    </dbReference>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO25521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="514" mass="59071" checksum="7FFDCC06D311C4C2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMH5</accession>
    <name>A0A174DMH5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional folate synthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Dihydroneopterin aldolase</fullName>
                <shortName evidence="11">DHNA</shortName>
                <ecNumber evidence="11">4.1.2.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">7,8-dihydroneopterin aldolase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
                <ecNumber evidence="11">2.7.6.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
                <shortName evidence="11">PPPK</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
                <shortName evidence="11">HPPK</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">folK</name>
        <name evidence="13" type="ORF">ERS852471_01239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EC" id="2.7.6.3" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26791">
        <property type="protein sequence ID" value="CUO26791"/>
        <property type="gene ID" value="ERS852471_01239"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HPPK" evidence="12">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO26791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="31938" checksum="4D6BD35B292C8689" modified="2016-09-07" version="1">MMDKVYLKDIEIFANHGVFKEEKVLGQKFILSLELSLDFKESAVSNDLTKSVHYGELCHKVEKLFQEESCDLIETVVDKIAKFVLEEYKIVNEVKVLLKKPWAPINRHLDYAAVETTRKRSVAYIALGSNIGDKKKYIEDAIVKIAEIKHVEVIKEAEIIDTKPWGYEEQDDFLNTAIGVETLLTPKELMKELLRIEKELDRVRELRWGPRTIDLDIILFDDIVSNDEFIIIPHPQMHLREFVLEPLNEIAPYAIHPLKNKRIFELLNDLKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZT9</accession>
    <name>A0A174DZT9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264865.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29360">
        <property type="protein sequence ID" value="CUO29360"/>
        <property type="gene ID" value="ERS852471_01293"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1813372at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023804">
        <property type="entry name" value="DUF3792_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12670">
        <property type="entry name" value="DUF3792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04086">
        <property type="entry name" value="TIGR04086_membr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="125" mass="13118" checksum="D62D119DAC1ECC05" modified="2016-09-07" version="1">MEIKSYFNNVLKGVVGAFAVTVLLTAIFSLLISFVEFSPAVFSGVFVVITSLGLIFGTIVAAKLQGEKGWLVGLAVGVLFYIALYATGVLFGAEPTLGVYDFIKFGLSVLVGTLSGMLGINLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E018</accession>
    <name>A0A174E018_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ggdef/hd domain protein</fullName>
            <ecNumber evidence="5">2.7.7.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ycdT</name>
        <name evidence="5" type="ORF">ERS852471_01332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.65" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264933.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31044">
        <property type="protein sequence ID" value="CUO31044"/>
        <property type="gene ID" value="ERS852471_01332"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD/PDEase_dom"/>
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        <property type="entry name" value="HD_GYP_dom"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
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            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="558"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUO31044.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="558" mass="64305" checksum="8F442D3810AA49B8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6K7</accession>
    <name>A0A174E6K7_9CLOT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31935">
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        <property type="gene ID" value="ERS852471_01355"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2143632at2"/>
    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO31935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="36402" checksum="69B22353C76228E6" modified="2016-09-07" version="1">MKKFIIITLSIIIIFLLGLNIYIVSSNDSISSSVDNLQSRKSEIDSLNSYSTNIINLAHIQKSFLLTGSENFKNQYSTSLESAYNTLDELLSNSTITNSDKVEIVNYLNDYENINNDFFENPPTLPLSQELEDKVLKSDEIQNNILGKLSTIIAAKTDSTSKTSSNISNSISSQNNIVKVLSSFFTLVISGPIYYFIKKYKNGEITFNNIIDTINEGEKIVDKYSNVLTYINITEKINSQLEKDWQEVYNLVTSLQSSISNIRSQLLKLQQSDSYTFKEKLEEIEIQVLEIKLLVKQLPNYHQFISDLSKNLTKCTENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJI0</accession>
    <name>A0A174EJI0_9CLOT</name>
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        <submittedName>
            <fullName evidence="3">Nucleoside recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">spmA</name>
        <name evidence="3" type="ORF">ERS852471_01444</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36898">
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        <property type="gene ID" value="ERS852471_01444"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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            <end position="25"/>
        </location>
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        </location>
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            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO36898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="191" mass="20469" checksum="7DEC2E58ED5E97A5" modified="2016-09-07" version="1">MINYIWFIMIFLGILVSIFTGNGEAMSNTIISSIDSTVTFIISLVGLMCFWCGVMKVAEKSGLTEKLAKLMKPILKVIFKEAAKDEKALGAIVMNITANMMGLGNAATPFGIKAMEEMDRLNRDKGRASNDMALFLVLNAACVQLVPSTVISIRAAAGSTNPGVIILPAIISTTVAAIVGVICAKILQRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPD4</accession>
    <name>A0A174EPD4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39654">
        <property type="protein sequence ID" value="CUO39654"/>
        <property type="gene ID" value="ERS852471_01500"/>
    </dbReference>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO39654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="45967" checksum="207447CFF1F43A3D" modified="2016-09-07" version="1">MDFKKSRITILKILISTVLLFLLTLSVNYYINYNYSKTLNTFYSEFNQCDFNDAKETLSDNSFVLKLKKKAMTSEVSKYFTSIITTLCNELKNNNITSDQAVTVFKEIKSYDILDESLDKLILTLDQDYVLEDSSLYKHYLDLALEKYNVGQYSEAIEMLSKIPYSQLEYYNTAQDYIEKCKDSYKQSLFNEADKLSEEDYYTKAIDLLSNVDESIVSSTDKDIQNKISSIEIAREEYLSSQYYIDNAQPTSTSLLQNLNSETINTLNIESNTPYLIYVNLNDQKTYVYEGSSNNWTLERDFPCSSGIESEATPKGVYTITGRGDWFYSDEYEQGGKYWVQFWGDYLFHSLPYDETQNTIVDYTLGVPASHGCIRLAVEDSKWLFENMPDDTKVIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETH0</accession>
    <name>A0A174ETH0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative reticulocyte-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265260.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41382">
        <property type="protein sequence ID" value="CUO41382"/>
        <property type="gene ID" value="ERS852471_01514"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1537568at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="25120" checksum="04032BCAFF3A634B" modified="2016-09-07" version="1">MNNKLDKKSSCILTITLILLISLLVNVYQSIAGIEYKKEIGNEINKSIEEIRTRNESILLTLEGCISSQSITSEEILTLYKNYNLINIAELNLWEKYLKNIETSWFKKDNKVDLTGTDQNEVFANIEGLIYNLLINYMSNDMNSIKLDDKLAMDISVMKEISYELNTYINSFMEEKLSNLEGEEKAEKMINKGYWIDILKGIEEINSKYKNYMFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EU15</accession>
    <name>A0A174EU15_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phoR_8</name>
        <name evidence="10" type="ORF">ERS852471_01504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO40971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265242.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40971">
        <property type="protein sequence ID" value="CUO40971"/>
        <property type="gene ID" value="ERS852471_01504"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="474"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="535"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO40971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="748" mass="86670" checksum="10A84A10AC6D5FF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EV81</accession>
    <name>A0A174EV81_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tyrS_2</name>
        <name evidence="7" type="synonym">tyrS</name>
        <name evidence="10" type="ORF">ERS852471_01524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265280.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41873">
        <property type="protein sequence ID" value="CUO41873"/>
        <property type="gene ID" value="ERS852471_01524"/>
    </dbReference>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO41873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="406" mass="45415" checksum="B277727F744CDE2E" modified="2016-09-07" version="1">MANVLDELLDRGYIKQFTHEDETRELLEKEKVTFYIGFDPTADSLHVGHFIAMMFMAHMQRAGHRPIALIGGGTAMVGDPSGKTDMRSMLTKEQIAHNVSCIKKQMEKFIDFSDDKAILVNNADWLLNLNYVDFLREVGMHFSVNRMLTAECFKQRLEKGLSFLEFNYMLMQGYDFYVLSEKYGCKMQLGGDDQWSNMLAGADLIRRKSQKQAMAMTCTLLTNSQGQKMGKTVGGALWLDPNKTSPFDFYQYWRNVDDADVEKCLALLTFVPMDEVRRLGALEGSEINKAKEVLAFEVTKLVHGEEEATKAQAAARALFAGGADMSNVPTVTISKELLGTSILDIMAQTKIVPSKAEGRRLIQQGGLSLNGEKVTDIATVLTEADLKDGEALIKRGKKNYNKIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYN8</accession>
    <name>A0A174EYN8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nupX_2</name>
        <name evidence="10" type="ORF">ERS852471_01508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265250.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41150">
        <property type="protein sequence ID" value="CUO41150"/>
        <property type="gene ID" value="ERS852471_01508"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437016at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="9">
        <location>
            <begin position="90"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="192"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO41150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="402" mass="41932" checksum="C60AFCEA2A690A8B" modified="2016-09-07" version="1">MAILNSILGIAFIFLVAFLLSNNKKKINWRTIIIGFLIQFGFALAALKWSVGKFILSKIALGVQSVINYANEGIKFLFGSLTNDGSIFAVNVLGVIIFISAVVSVLYYLGIMQFVIKIIGGALSKLLGTSKLETISASANIFLGQTEAPLLIKPYVEKLTESELFTVMVGGLASVSGSILVGYSLLGIPIEYLVSASFMSAPAGLIMAKIIIPELKQAKVNDQIEMVKDDSANVVDAAAKGAIDGLGLVLNIAAILLAFVALIALINGVIGWVGGFFGIANLSLQSILGYIFAPVATIIGVPMKESIAVGSLIGQKIILNEFVAFTSLSPLMETLSAKASAIATFSLCGFANISSIAILIGGIGGMAPSRKGDIARLGWKAIIAGTLANLLSATIAGLLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZN3</accession>
    <name>A0A174EZN3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265318.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42747">
        <property type="protein sequence ID" value="CUO42747"/>
        <property type="gene ID" value="ERS852471_01544"/>
    </dbReference>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="301" mass="34962" checksum="CC9E3885DBA9E706" modified="2016-09-07" version="1">MEKVAIVILNYLNYKDTIECVESLNNDKYCDKEVVIVDNGSNNDSWTVLEAKYCNSRVHLLKSDKNLGFAKGNNIGINYAVNKLNCKFVLLVNNDTIFNDSNLITELMNAYEEGVAVIGPRIIAANGVEQNPVPAEVSKARIEEEFAIYKSLKYRFYNGDLYIKLNENEYFKKMKIMIKKYLLRRGNIDKKGEISNNKKSQDLVLHGACMLLTKDYFNYYSGLFPNTFLYYEENILTLLTKKVGLYKKFINSVNIYHKEDQSSKMSFNNLSKVKKKYLFDSMKLCKELFDLSYDQIINKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSG3</accession>
    <name>A0A174FSG3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloendopeptidase-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265617.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51529">
        <property type="protein sequence ID" value="CUO51529"/>
        <property type="gene ID" value="ERS852471_01706"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="154"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO51529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="260" mass="28554" checksum="D2B17FB447A22A87" modified="2016-09-07" version="1">MNSNNKDKVKDFFRKEGFYFVLFICLCIVAVVAAFTIKKNNELKQSNNQNNEFTLNVEESVNDSTEASRNEMPNADRVEIGDNVAEESEELDEVADNEEVDNYTEVADNTEDVPVSTTVTEVVFQLPLEGTVSREYKEMIRLQDNENGTVDRTRRGIDLNASVGTAVTAAAEGKVIEVSKSTEDGNFIVIEHTNGLKTKYANLDAEVSVAVGDIVSAGDEIGTVGNSSMIFTSEVCGDVLNLQVEDSEGNQLNPSDYFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZI6</accession>
    <name>A0A174FZI6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
            <ecNumber evidence="2">3.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265713.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54019">
        <property type="protein sequence ID" value="CUO54019"/>
        <property type="gene ID" value="ERS852471_01756"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="21065" checksum="8201C1FC9B5073D9" modified="2016-09-07" version="1">MKDNFVFLGDSLTFGYGVNKKECWVELIASTSEFNIINKGINGSTTIDMLVRFDKDVISLTPRKVFIMGGTNDLLCNRSILSIKSNIELMIKDLKLINSDIIIGIPPDIIIEDAYNLFMESPTYDYCKASLPILRENLISLCNNYSCKYVDFYSLTKNNIKSNIYLDGIHLNPKGHQLMLKEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9C4</accession>
    <name>A0A174G9C4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage III sporulation protein AA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIIAA</name>
        <name evidence="4" type="ORF">ERS852471_01823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265842.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58217">
        <property type="protein sequence ID" value="CUO58217"/>
        <property type="gene ID" value="ERS852471_01823"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014217">
        <property type="entry name" value="Spore_III_AA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02858">
        <property type="entry name" value="spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="137"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO58217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="307" mass="33836" checksum="B2ABC9E01589626D" modified="2016-09-07" version="1">MVYGEEVIRILPEKIANETKKFISDGTIQEIRIKVGKPIILILSNEEKVLNYVTTNDEVKGILVKISNYSLYAYEEEIKQGYITIKGGHRVGIAGECVISNGEIKTIKNISSLNIRISKAVVGSAKKIMPIITGGDRIYNTLIVSPPKCGKTTILRDIAKNISNGVYSLGLKGKKVVIIDERSEVAACYNGVPQMDVGIRTDVLDNCLKKTGMIMAIRSLSPDVLICDEIGTLGEVEALNMAFNSGVNIVVTVHGFDIEDIYSRKVFKELIDESIIERVVILSSRKGAGTIERIYKIERGEIKCLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GA20</accession>
    <name>A0A174GA20_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein AG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIIAG</name>
        <name evidence="3" type="ORF">ERS852471_01817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265832.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57968">
        <property type="protein sequence ID" value="CUO57968"/>
        <property type="gene ID" value="ERS852471_01817"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762318at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014195">
        <property type="entry name" value="Spore_III_AG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02830">
        <property type="entry name" value="spore_III_AG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO57968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="22310" checksum="F79D13266F987BB4" modified="2016-09-07" version="1">MDKEKLNNELKKIVNNKTFFNALAVLLVIAFLWLAYTAFFTGSSNEKSSLTPKGAQEVTVEEAEISKEILDYEAEQKQELQDILSKMEGVGKVDVKMHFESGEVKVPAYNSTTQTAETREEDSQGGTRSTIQETGGDTVVMYSDGSTNEPFIVQTYKPKITGIIIVAEGASNSKLRYDIQIAVSTLYNLSLDKVNVYPMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDQ5</accession>
    <name>A0A174GDQ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">sepF</name>
        <name evidence="6" type="ORF">ERS852471_01842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59050">
        <property type="protein sequence ID" value="CUO59050"/>
        <property type="gene ID" value="ERS852471_01842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO59050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="146" mass="16470" checksum="52F0ED3F8DBE8A7B" modified="2016-09-07" version="1">MSMLSKFKEMVFGEYDEDFEDIEENEEEEEIEEVEPIISKQKGNKVVNIHNSASPKIMVVKPSSYEEAKEIADALKNRKIIVVNTTALEAKVAQRLVDFISGAVCVLGAQLQEIEQRVYLLSPSNVEVSSELKTEISSKALFSWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GE48</accession>
    <name>A0A174GE48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsW</name>
        <name evidence="8" type="ORF">ERS852471_01848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265889.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59296">
        <property type="protein sequence ID" value="CUO59296"/>
        <property type="gene ID" value="ERS852471_01848"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013438">
        <property type="entry name" value="SpoVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02615">
        <property type="entry name" value="spoVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO59296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="41683" checksum="F64B99B81ED0B2AC" modified="2016-09-07" version="1">MRFNEPLNKKKLGEVDYGIFYSLFLLLAIGIVMIYSASSFYAMFKYKNSMYYLIRQGAFAIIGVIALVMMMKFDYHKLKKITPYLLIATIPLLIAVFFFPEVNGARRWIKLGILSFQPSELTKYVVVMFLAMSIDMKGDRIKRFWDGLVPYLGVAGFFAAMILAEKNMSIATIIMIVTFIMLFVAGGQIKHLFGIIFPAMLTLAIFFIFSSDYRRARMLNFIDPWKDAAGDGYQLIQSFYALGAGGITGLGLGESRQKILYMPEPHNDFIFSIIGEELGLVGCLFIVGLFLFLIWRGIRVAMKAKDTYGKLLAVGITSIIAVQAIINIAVVTGSMPVTGVPMPFISYGGTSLVINLMAMGILLNISSQIEKSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMN6</accession>
    <name>A0A174GMN6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 domain-containing protein repeat-containing protein</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcpC</name>
        <name evidence="2" type="ORF">ERS852471_01938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266050.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63834">
        <property type="protein sequence ID" value="CUO63834"/>
        <property type="gene ID" value="ERS852471_01938"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="912" mass="106449" checksum="8CA717F3E8420E9E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H1T2</accession>
    <name>A0A174H1T2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HRDC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266242.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68211">
        <property type="protein sequence ID" value="CUO68211"/>
        <property type="gene ID" value="ERS852471_02035"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="16632" checksum="3CFD30AD076530E9" modified="2016-09-07" version="1">MKDIGEFFIINNKSISYDYNKKYSLTEEDFMEQNIEKEIEEKILEEIYGEKGIDEVETPVLEEVKEKVKSYEEVFNALKEYRLNKSREEKVKPYFIYNNEMVEEIIKLKPEAKEDLISIKGFGPVKIEKYGQDIVDIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3E3</accession>
    <name>A0A174H3E3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_1</name>
        <name evidence="2" type="ORF">ERS852471_02069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266295.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69522">
        <property type="protein sequence ID" value="CUO69522"/>
        <property type="gene ID" value="ERS852471_02069"/>
    </dbReference>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="304" mass="34752" checksum="6F553A2499C260AC" modified="2016-09-07" version="1">MKIISVVNYKGGVGKSTVVSNLGALLALDGYKVLLIDLDPQASLTFSYMGIDDWKRTYKDTKTIKTLFNSIINRKKDSIKKYITTDLKANTIITKNGGQAISLLPSSTDLYEIQIELARSISGNTKRKYTKNKLRCISGLREELMTVYGEYDFVLLDCQPSFDLITQSAMYASDSYIVPTKLDYLSTVGAPTLLEHVENLKKEVETGINEFDFYQFKHMDVKLMGVLPTMVKIINGQPKLMHKQYLNEINYEENLDIFNSKIRANDEEIDNNNDIPFVLTNLNRKKTPIHLDFESLEKEFLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6U3</accession>
    <name>A0A174H6U3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine synthase</fullName>
            <ecNumber evidence="6">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">metH</name>
        <name evidence="24" type="ORF">ERS852471_02097</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70584">
        <property type="protein sequence ID" value="CUO70584"/>
        <property type="gene ID" value="ERS852471_02097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017215">
        <property type="entry name" value="MetH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037472">
        <property type="entry name" value="DHPS_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 19 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 19 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="20">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="21">
        <location>
            <begin position="323"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="23">
        <location>
            <begin position="590"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="22">
        <location>
            <begin position="686"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CUO70584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="807" mass="88798" checksum="9F606799DA82EDFD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H741</accession>
    <name>A0A174H741_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ORF">ERS852471_02100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266344.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70704">
        <property type="protein sequence ID" value="CUO70704"/>
        <property type="gene ID" value="ERS852471_02100"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1425269at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO70704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="33035" checksum="31484DFF6599B068" modified="2016-09-07" version="1">MNIREIFDQKKLVFSFEVFPPKSTSPIKNIYKALNELVKLEPDFISVTYGAGGSTINNKTTEISSLIKNIYGIESLAHLTCISSTREQIVDITERLKLEEVENILALRGDDNGTSCGDFNYANELISYIKEKESFNIIAACYPEGHIANKDIKLEIDNIERKIESGATSFISQLFLDNNIYYKFLEEIEKRNIKTKIQAGIMPVINAKQMRRITELCGATIPLKFKKIMERYENNPEALTQAGIAYATDQIIDLSSSNVDGVHLYTMNNPYVAKNISKNIGKIISSINEVQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7H0</accession>
    <name>A0A174H7H0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69286">
        <property type="protein sequence ID" value="CUO69286"/>
        <property type="gene ID" value="ERS852471_02064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="44" mass="4978" checksum="E60194AE865140A4" modified="2016-09-07" version="1">MKNKKNSKVNTDPSSSNYAQDVRNKALENTPFGEDEPSTKTDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7Z4</accession>
    <name>A0A174H7Z4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HRDC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266287.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69318">
        <property type="protein sequence ID" value="CUO69318"/>
        <property type="gene ID" value="ERS852471_02065"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="56"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="286"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO69318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="358" mass="42115" checksum="F1FAFB41B93F62D2" modified="2016-09-07" version="1">MAIFKNLFGIREIKTPVFYKDFKEENKELSDLLELKNKVKSSKVKYIERDIEFLKNVIQGEKNVYLELKNSSIPMICLHDIKIKDGDYIAQLDFIVITTRFVMILETKGLNGEIHINEAGDFVRYIKDKNNKIIDSEKVISPILQNNKNVKVVRDLLIEAGIIKTLPIFSSVIVSNDKSIVNKSKAPKKVKYEIFTYDELTELINRKLSCYSKEKKMFEDKMKKIAEYFIANNIDIKYDYNKKYNLTEIDFIEVKLEEKSIIEDIGYSSKEEVIDENLNNEVLDKVKSYEQLVDELKKYRTYKAREENIKPYYIYNDEMIEEIIKLNPDNKKKLIQIIGFGPSKIDKYGQDIIDILRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD01</accession>
    <name>A0A174HD01_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">btr_2</name>
        <name evidence="2" type="ORF">ERS852471_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266427.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72763">
        <property type="protein sequence ID" value="CUO72763"/>
        <property type="gene ID" value="ERS852471_02140"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="307"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="408" mass="47042" checksum="2522BD7F7EE70AE8" modified="2016-09-07" version="1">MNDNISLDKIKYLCNLTFNTFNTSVCYISNKNNILYSVKNMSPTDISIDFDNLLIKLSMSYCTLNIPILVTTKHDFKFIIINLIFKEYVGSIVIGPILSSPIDKNYIYNNNYISNIDKNLIYKYYSEIPVIEISTILNWISLLFFSIYNSPMYNDYILKDDNSYLDINFKVKNTYKTLLTTNRQNTTHHHSNKLIRCIYNDIKTGNIDKLLLDLKSKPDGELGTVVKSNDLRNRKNLIIALITLCTQASIDGGVSCEDAFTLSDSFIQNIEEINNISSFITIESKIPIAFAAKVKEVQKFNYSKITYTCIDIILKHLYEDISLLKISKMLNLSPPYISSKFKKEVKISLSEYILKCKIDEAKYLLTHTNYSILEVSTLLCFHDQSYFTKTFKRFTGITPKKYTSKTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD58</accession>
    <name>A0A174HD58_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">walR_2</name>
        <name evidence="9" type="ORF">ERS852471_02103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266358.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71276">
        <property type="protein sequence ID" value="CUO71276"/>
        <property type="gene ID" value="ERS852471_02103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO71276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="240" mass="27554" checksum="2B6D936ABD394FDB" modified="2016-09-07" version="1">MNNIFEKFKVLIIDDEEDITDILDTVLKREGFSNIYIANNGTDGIELFKKVNPDIVLLDIMLPDISGYDVFNELRKDSQIPILFISAKTEEVDRLLGFAIGADDYITKPFSAKEVAFRLKARLKTFDNVVTNKNIKENKIIKFGDIEINEETGEVYKSGKLLELTAKELKLLIYLVNHPNRILSKETICNEVWGEDFFGYDNTITVHIRRLRKKIEDNPSKPKYLITVIGLGYKLVMKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFV1</accession>
    <name>A0A174HFV1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kfoC_2</name>
        <name evidence="2" type="ORF">ERS852471_02126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266399.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72267">
        <property type="protein sequence ID" value="CUO72267"/>
        <property type="gene ID" value="ERS852471_02126"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="392" mass="46138" checksum="87BF14264EB8F723" modified="2016-09-07" version="1">MRVSVIIPSYNSRERLYYNLITLNNQDCDYDTFEVVVVDNGSNDNTIEMLKEFESKYPLKFVRVKENKGIAHGRNEGVKRAEGDILIFHDSDMLAPIDFITRHLKHHEEGNIVVCGVPWKRINTFYYKELEKAGLNYKDDILPIYGMDIDDIKMDKQPLISSESIVDRSYLNYIYNLDTDFMKILKGILDRYGDNFRDYALPWRFFITNNVSVERSRVIQVGMFDESIVGYGYEDYDLGIRLYKSGSKFVFDKDILNVHQEHPSNIRISEAHDNVNYICSKYNNVYFLDVILVCVSYVTSIDGSTINELVIDINNMLPVTSFRRLLEIFLELIQTCRKRFFVEGVKDRYSIMPNIYINLEELIMELKYLRDKFGIKYFTEAMLALIRDIYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGW9</accession>
    <name>A0A174HGW9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266407.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72388">
        <property type="protein sequence ID" value="CUO72388"/>
        <property type="gene ID" value="ERS852471_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023415" evidence="1">
        <location>
            <begin position="22"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="827" mass="94043" checksum="FCE8FEE304F765EA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKF7</accession>
    <name>A0A174HKF7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ORF">ERS852471_02214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266544.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75374">
        <property type="protein sequence ID" value="CUO75374"/>
        <property type="gene ID" value="ERS852471_02214"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO75374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="450" mass="49911" checksum="A7FE1EE0FD1817B8" modified="2016-09-07" version="1">MNKGLSLDLSKVQPYANLSELDMMEGMVKYAHDTVHEKTGAGNDFLGWLDLPVNYDKDEFERIKVAAEKIKSNSDVLIVIGIGGSYLGARAAIEMLTNNFYNMLSSDKRKTPKVFFVGNNISSTYITDLFEAIEGLDVSVNVISKSGTTTEPAIAFRMFKDFMEKKYGVDGAKERIFATTDKARGALKGLADTMGYETFVVPDDVGGRFSVLTAVGLLPIAVAGINIDEMMQGAADARKVYSNPSLKENECYQYAAMRNALYNKGKKVEVMVNYEPCLHYFNEWWKQLYGESEGKDQKGIFPAAVDFSTDLHSMGQFIQDGTRIMFETVLNVEKANKEIVIEEAEGNVDGLNFLAGKTVDFVNKQAFNGTLLAHCDGGVPNMILNIPELSPYYFGQMVYFFEKACAISGYLLGVNPFDQPGVEAYKKNMFALLGKPGYEELKAELEARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTV7</accession>
    <name>A0A174HTV7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein, alpha subunit/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">etfA</name>
        <name evidence="6" type="ORF">ERS852471_02241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76359">
        <property type="protein sequence ID" value="CUO76359"/>
        <property type="gene ID" value="ERS852471_02241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="5">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO76359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="37097" checksum="5BDEA214FD94D20A" modified="2016-09-07" version="1">MMNIADYQGVWVFAEQRHGELQKVSLEILGESRRLANELGVKLTAVLLGNNIGHLANKLGEYGADEVLVADHAELENYTTDGYTKVLCDLVNDKKPGIFFIGATFIGRDLGPRVAARLRTGLTADCTSLAVEVENGALLATRPAFGGNIMATIACPDHRPQMATVRPGVFSRLTEKNYDFTVENVEVKLEASDIRTTILEIVKANKEVVDISEAKVIVSGGRGVGSKENFTLLQELADAFGGVVGGSRGAVDKGWIERDYQVGQTGKTVRPSIYIACGISGAIQHVAGMQESDMIIAINKDETAPIMKVADYAIVGDLNKVIPEMISELKSMESKESEIAVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBK0</accession>
    <name>A0A174IBK0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine--tRNA ligase MetG</fullName>
            <ecNumber evidence="8">6.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metG2</name>
        <name evidence="8" type="ORF">ERS852471_02448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266942.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84554">
        <property type="protein sequence ID" value="CUO84554"/>
        <property type="gene ID" value="ERS852471_02448"/>
    </dbReference>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="7">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="7">
        <location>
            <begin position="314"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO84554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="655" mass="76620" checksum="970A0449CC926D8A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IEX4</accession>
    <name>A0A174IEX4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fer_2</name>
        <name evidence="7" type="ORF">ERS852471_02467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032116987.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85802">
        <property type="protein sequence ID" value="CUO85802"/>
        <property type="gene ID" value="ERS852471_02467"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO85802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="56" mass="5642" checksum="85BC3E3542BC35A4" modified="2016-09-07" version="1">MAYVIEDSCVNCGACAAECPVNAISQGDTQFVIDADTCIDCGNCANVCPVGAPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFI3</accession>
    <name>A0A174IFI3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">katG</name>
        <name evidence="12" type="ORF">ERS852471_02422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266902.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83699">
        <property type="protein sequence ID" value="CUO83699"/>
        <property type="gene ID" value="ERS852471_02422"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49441at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="129"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-95)" evidence="8">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO83699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="731" mass="82103" checksum="E83FBE4E889F6522" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGF2</accession>
    <name>A0A174IGF2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">disA</name>
        <name evidence="12" type="ORF">ERS852471_02477</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267006.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86273">
        <property type="protein sequence ID" value="CUO86273"/>
        <property type="gene ID" value="ERS852471_02477"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1139866at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO86273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="354" mass="39680" checksum="1E94383D294C8E75" modified="2016-09-07" version="1">MRIKEDNEIKNILKLVSPGTSLREGLDNILRAKTGGLIIIGDGENVMKLVDGGFNINSEYTPAYVYELAKMDGAIVISGDLKKIVSANAQLIPDSTIATFETGTRHRTAQRIARQTGTLVIAISQRRNIITIYKGDLKYILKDSSVILANANQAIQTLEKYVNVLEKVINNLNILEFQDLTTVFDVTTAIQRTEMVMRIVEEIKKHIVELGNEGRLISMQLNELIKNIERDGILLIKDYCNDEADADEIYKEIQKLNSEELLDLDNLSKLLGYAGVSLVDTLISPKGYRILSKIPRIPTSIIENLIKHFDSLKNVIKASKEDLDMVEGIGEARATAIRNGLKRIKEQIYLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IR30</accession>
    <name>A0A174IR30_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ychM</name>
        <name evidence="3" type="ORF">ERS852471_02551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267117.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89804">
        <property type="protein sequence ID" value="CUO89804"/>
        <property type="gene ID" value="ERS852471_02551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="397"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO89804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="480" mass="52372" checksum="C554850987403F75" modified="2016-09-07" version="1">MEEYKREWIGNLRTDLVAGIVTCMALIPEAIGFTIVAGVDPMVGVYSCFTMSIVTAIFGGRPGMISAAAGSMAFVLASLVREHGVEYMLLATILAGIFQVVFGFLKIGKLLKFIPKPVMIGFVNALGIMMLKAQLPHFKGSYILVLLGVIGVAIIYLLPRITKIIPAPIVSIVIITLIVFISKIDVPTLGDMGKITTELPRFFIPNVPLNLETLRIILPYSFSLSIVGLVESLLTAQLVDDMTDTRSNKNRECVGQGVANIVTGFFGGIAGCGMIGQTIINQEYGGRGRLSTLTPGTVMLIFVILFNKLFIRMPVVALASVMVVVAITTFDWNSLRTLGKVPIPDTIVMITTVIIVLLTNNLAYGVIVGIILSSVFFTSKTSNVQVEKVVECNKIKYSVKGPLFFAVTTDFIDKFDYHEKVEEVNIDFSNANIYDESAVDAIDKVIMKFTKNDIKVNIVGMNDNSKEIVEKISVNFNNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVG4</accession>
    <name>A0A174IVG4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">buk</name>
        <name evidence="10" type="ORF">ERS852471_02544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267103.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88965">
        <property type="protein sequence ID" value="CUO88965"/>
        <property type="gene ID" value="ERS852471_02544"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="356" mass="38672" checksum="B452704529989080" modified="2016-09-07" version="1">MSYRLLIINPGSTSTKIGVYDGEHEVLVETLRHSAEEILSYKTIYDQKSFRKNVILDVLKNKKFDITTLDAVVGRGGMLKPMPGGTYEVDESMIEDLKAGVQGQHASNLGGILSKEIADELGIKAFIVDPVVVDELQDIARISGMPELPRKSKFHALNQKAVAKRYGKETNKGYENLNLIVVHMGGGVSVGAHKNGRVIDVNNALDGDGPFSPERAGSVPVGDLIKMCYSGKYTESEVFSKIVGKGGYVAYLNTNDARDVLKLKQEGDKYGSLIYDAFIYQISKEIGSMATVLMGKVDAIILTGGIAYGKKVCDDINSYVGWIAPIVVYPGEDELLALAQGAIRVLSGEEKAKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVL4</accession>
    <name>A0A174IVL4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase/phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gmr</name>
        <name evidence="6" type="ORF">ERS852471_02594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.52" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91434">
        <property type="protein sequence ID" value="CUO91434"/>
        <property type="gene ID" value="ERS852471_02594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="PAC"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR035965">
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    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sensory_box"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="41"/>
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            <begin position="263"/>
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        <location>
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            <end position="478"/>
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            <end position="739"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="739" mass="86192" checksum="4726BEF731ACCF88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J0T6</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">ERS852471_02636</name>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93382">
        <property type="protein sequence ID" value="CUO93382"/>
        <property type="gene ID" value="ERS852471_02636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
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            <dbReference type="EMBL" id="CUO93382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="58" mass="6528" checksum="AB63B788156A9E58" modified="2016-09-07" version="1">MDKYKEILKNTPDYEEYTANEAKLSIDEMRELGLLKCGGCCSSKNGCSKKTKCCKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J265</accession>
    <name>A0A174J265_9CLOT</name>
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        <submittedName>
            <fullName evidence="2">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ERS852471_02585</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91200">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO91200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="16310" checksum="3ACED6FE5C42E694" modified="2016-09-07" version="1">MINENLRKLRIYNKYTQEDIAEKLGVSRQSVAKWENGESIPDINKCMELAKLYDVTLDDLVATIINKESKLVTPKGKFMFGVVKVGERGQIIIPKKAREVFNIKAGDRLLILGDIDFGIGIKRCEDVEEFFNQMISSQVIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J9Z9</accession>
    <name>A0A174J9Z9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase TagO</fullName>
            <ecNumber evidence="7">2.7.8.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tagO</name>
        <name evidence="7" type="ORF">ERS852471_02678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.33" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267345.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95106">
        <property type="protein sequence ID" value="CUO95106"/>
        <property type="gene ID" value="ERS852471_02678"/>
    </dbReference>
    <dbReference type="OrthoDB" id="728505at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036380">
        <property type="term" value="F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO95106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="317" mass="35205" checksum="FE9E24D4E715295F" modified="2016-09-07" version="1">MKYLLAMIIAFSVVYFITPMLMKMSFKYNFTDKPTKRKIHRGETPLCGGIAMYIGFFIAYFISFWNHPFDEKYGIFIGATLIVGIGLIDDYYKSVGKEFAIMPRLIVQLLAATIVFFSGVSFNGFTNPFTDTYIALPTIIQYVLTVTWIFGVTTVINWSDGMDGLAGGLSFISAMTFAATAIVLAQPPSLIFSLITGGCVLAFLLYNKYPAKIFMGDSGANFLGFILSIIALDGAFKQATILSLLIPILALAVPIFDNIFVIFKRFSEGKPVYQADRSQIHYRLKEKGLTTIEVVTSITLISLIFSIISIIILLVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBB6</accession>
    <name>A0A174JBB6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ORF">ERS852471_02714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267413.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96992">
        <property type="protein sequence ID" value="CUO96992"/>
        <property type="gene ID" value="ERS852471_02714"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO96992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="22898" checksum="B9911CA0368600EC" modified="2016-09-07" version="1">MEEKRELEQDEVLEEVKEKETNEEIVEEVEDTTEEVVEENNEEDTLSMVRKLKDEKKKLDNELNTLKDRLMRLSAEYDNFRKRTSKEKEGIYTDACVDVLKELVPVLDNLERAIAVDGSVEDLKKGIEMTIKGFQSSLEKLGVEEIDTTSGFDPNFHQAVMHVQDENFEKNSVAEVFLKGYKRNDKIIRYTMVKVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JLQ1</accession>
    <name>A0A174JLQ1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267465.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98095">
        <property type="protein sequence ID" value="CUO98095"/>
        <property type="gene ID" value="ERS852471_02741"/>
    </dbReference>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO98095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="29271" checksum="045FB402E1F02263" modified="2016-09-07" version="1">MKKVKEIIEVMETLAPTFLKEDFDNVGLMVGDREKEVKKVLLALDCTLKVVEEAKENNVDLIITHHPLIFRRPNNITTDTIQGRKIIELIKNDISLYSSHTNLDSAKSGLNDSIPKLLGYDSSEILEVNKRDEKAGLGRIVTLDKPTKLDEIVDNVKKALNINNLRVVKGKEEVNKIAIINGSGQDFIGKAVSKGADCIITGDTTYHFASDYKEMGINIIDAGHFASEQIVFFNVMKNIIDKFTDVEFILSKVEEDPYTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZ99</accession>
    <name>A0A174JZ99_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">ERS852471_02839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267643.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03107">
        <property type="protein sequence ID" value="CUP03107"/>
        <property type="gene ID" value="ERS852471_02839"/>
    </dbReference>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="246"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP03107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="386" mass="42982" checksum="C20097A47B77BB87" modified="2016-09-07" version="1">MDVNIRPVWAEVNLDNIINNIKEIKKNINGEEIIAVVKANAYGHGAVDVAPVLIENGADRLAVAMLSEALELREAGIKVPILILGYTDVAFSEMLINNDIEQTVYSLDYAKELSKKAEALGKVAKIHIAVDTGMGRIGFLPNEKSVEEVVEISKLSNLRITGIFTHFSNADEQDKSYAHNQIEKFNSFINEIEKREVNLGLKHISNSASIIDIEDAHYNAIRPGIILYGYYPSDYINKDKLKLMPALSLKCQVIHVKELPKGEYIGYGRKFRTERDSVIATLPIGYADGYVRGLYEKAHVIINGKLAPVVGKICMDQCMVDVTDIGPVKVGDEVVLLGEDNGVKNNADDMAKMLDTINYEILCMIGRRVPRIYIKDGKMVNVRNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K0D2</accession>
    <name>A0A174K0D2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF1836)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267661.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03467">
        <property type="protein sequence ID" value="CUP03467"/>
        <property type="gene ID" value="ERS852471_02848"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1504619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014975">
        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40056">
        <property type="entry name" value="PTHR40056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP03467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="196" mass="22890" checksum="CCFE731A826C297F" modified="2016-09-07" version="1">MADKMDENYIRELAEEISKDSIVSYDDLPKYDLFLSQVIDFLNDKFVDDKYTNNIVQNYIKSEVISKPEDGKKRGYTKIHLVQLVLLSFMRPVLTTEEIKKVFRLAFNDINDRSDDIIAWETAYKIFVETQSNSFTEYLNTPALNEDKLNEVIKELKLDEKDENSIRTFVVVMTLIAQASAIKKLVQKIVNEYHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K205</accession>
    <name>A0A174K205_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pyrD</name>
        <name evidence="11" type="ORF">ERS852471_02876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267714.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04871">
        <property type="protein sequence ID" value="CUP04871"/>
        <property type="gene ID" value="ERS852471_02876"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP04871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="31777" checksum="A0B7AFD9FBB44A42" modified="2016-09-07" version="1">MLKVNINGVDFKNPVIAASGTFGFGSEYNEFYDVGVLGGISSKGLTLNPKDGNNGIRVFETPSGMMNSVGLQNPGIERFISEELPKMRKLNTNVIANVGGGCIEDYETAVEKLRGTDIDMIELNISCPNVKSGGMAFGIKSEVAYDVVSKIKKIADKPLMVKLSPNAENIVEMALECERAGADSISLINTLKGLAIDPYKRKPVFDNVYAGVSGPAVKPVALRMVHEVAKAVSVPVIGLGGIVSGIDAIEFMMAGASAVQIGTVNFFNPNAGKEIIEQMEQFCKEQGIKDINEIIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5N1</accession>
    <name>A0A174K5N1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multicopper oxidase, type 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">copA_3</name>
        <name evidence="3" type="ORF">ERS852471_02902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267756.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05746">
        <property type="protein sequence ID" value="CUP05746"/>
        <property type="gene ID" value="ERS852471_02902"/>
    </dbReference>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP05746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="33703" checksum="73E99F5B9D837341" modified="2016-09-07" version="1">MVITPGIKNLDYEYVDGVKHFTLIAEEVTLELIKGLYVKAWGYNGSVPGPTIIVNQGDNVCIRVINKLPERTSVHWHGLDVPNDMDGVPPIEPSPFIEPNEYFDYNFKITNPPGTYMYHSHVNVMVQDNAGLLGGIIVNDPKDLKKKHYKDYLILLQEWAVDKLPWADIDPGTYNLTFKAPEFNFFTMNGKCYPLTEPLPVNFGDTVKVRFGNIQMHHHPIHLHGHQFKVVGADGFPIRKETQIYKNTILVASGETWDIEFIAKNPGIWPMHCHMPHHVTNNGAPGVGGMFTTVNYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7S5</accession>
    <name>A0A174K7S5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_02923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP06881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06881">
        <property type="protein sequence ID" value="CUP06881"/>
        <property type="gene ID" value="ERS852471_02923"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP06881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="22622" checksum="C96C6344B5865CED" modified="2016-09-07" version="1">MKELILKLKFDKPNNVGFFRRFISYMIDWYIGGILTSLPIILTYTAMNNGNIGIIEQNINIFEYPLNIIIGLASFMVAALYYVYVPMFINNGQTLGKKIMKLRIVNNDYTQASKKQLFIRQFVIILLLEGSLYTSSNMLHQVINEVTGANIVSIYNTIGIVITVFSALLVIMFKSRRALHDIIINTRVVTENSPELSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8L7</accession>
    <name>A0A174K8L7_9CLOT</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02905</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="84024"/>
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            <taxon>Firmicutes</taxon>
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    </organism>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05865.1"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05865">
        <property type="protein sequence ID" value="CUP05865"/>
        <property type="gene ID" value="ERS852471_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="37" mass="4323" checksum="1123B053335E6F75" modified="2016-09-07" version="1">MTKHKSEKIHEVVHKHDKKLNLHEIKEETGAGNGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8M8</accession>
    <name>A0A174K8M8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">steT_3</name>
        <name evidence="6" type="ORF">ERS852471_02960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267860.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08454">
        <property type="protein sequence ID" value="CUP08454"/>
        <property type="gene ID" value="ERS852471_02960"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="70"/>
        </location>
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        </location>
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            <end position="148"/>
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            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="407"/>
        </location>
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        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP08454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="440" mass="46050" checksum="7B58288C57064315" modified="2016-09-07" version="1">MNKELKKSLGLAAAFSTVVGVVIGSGVFFKPQAIYTATNGAPGLGILAWILGGLITIAGGLTATEVSAAIPKTGGMMIYIEEIYGKRYGFLTGWMQTVLFFPGTIAAVAVIFAQQASELLGSTSNNMKMVLPIAIGIILLTALLNTIGSSFGGSIQTVATLGKLVPLVLIIIFGFTKGNSTSILTPMVGEGVNPVTTLGQVLIATLFAYDGWINVGAIAGEMKDPGKDLPKAIVGGLSLVMAVYLAINVAYLWVAPASSLANVTSPASLVATKLFGPIGGKLISAGILISVFGTLNGYLLTGPRVVYALTKEKLLPGSNILSKVNKGGSPYNSILLISILACIYALTGQFNLLSDLTIFAVWVFYVLTFIGVIILRKTKPDLYRPYKVPGYPVIPIIAILGGTFVVINQLITAPLISLGGIIITIIGLPIYAYMNKKSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K918</accession>
    <name>A0A174K918_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_16</name>
        <name evidence="2" type="ORF">ERS852471_02903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267758.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05790">
        <property type="protein sequence ID" value="CUP05790"/>
        <property type="gene ID" value="ERS852471_02903"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="457" mass="49341" checksum="C3A021BC574A7210" modified="2016-09-07" version="1">MFKFKVDLIRDKNILKALVLFAVPIFISNVFQQMYNTMDTMIIGNVLGDTSLAAIGACGAVYELLIGFALGIGNGLSIVVARSYGSKDERLLKKSVAGSLVIGAIVTVVIMIISGLFLYPLLELLNTPANIINESYSYISVITLFVGVMFAYNLFAGLLRAIGNSVMPLVFLIISSVINVVLDLIFITQFNMGIAGAAVATVIAQGISAILCLIYIIKKCPILIPSKECFKVEKDLYKELAGQGLSMGLMLSIVSTGTVILQTAINGLGYLTIAGHTAARKLNSFCTMPVATMSLALSTFVSQNKGAEKYERIRKGVKVANIMAICWGAIITVALLFSASTLVKVLSGSTEPTVINNGALYLIINAPFYAILGMLLNLRNSLQGLGKKVVPLASSIIEFLGKCLFVALFIPSLKYLGVIICEPIIWCFMLLQLSYSFYKNPLIQGYKNGLNTLEQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGP6</accession>
    <name>A0A174KGP6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sinR_1</name>
        <name evidence="2" type="ORF">ERS852471_02972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267884.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08968">
        <property type="protein sequence ID" value="CUP08968"/>
        <property type="gene ID" value="ERS852471_02972"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP08968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7136" checksum="99665970678F797C" modified="2016-09-07" version="1">MEIGRKIRDIRISKNITQKKLAELAGISNTYLSDIERMRTSPSIKTLGSIANSLDKNIKEFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KME4</accession>
    <name>A0A174KME4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268055.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13142">
        <property type="protein sequence ID" value="CUP13142"/>
        <property type="gene ID" value="ERS852471_03057"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2038752at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026207" evidence="1">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="15532" checksum="AFB14D5D28947F47" modified="2016-09-07" version="1">MKKYLAILTLTIVVSIITGCTSNNVTKVTYHGESLNWESTMIFDEEDKQSLNIKYLGEEQFPIDVSFNAEFLSGNGSGGYMEYGELANDVFGGFTFENDYDKKIHGDVSKYGNKDSLEVFIKWNDKEETIVLNKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KS45</accession>
    <name>A0A174KS45_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268115.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14853">
        <property type="protein sequence ID" value="CUP14853"/>
        <property type="gene ID" value="ERS852471_03087"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1145595at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP14853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="35435" checksum="DFD19C79381063A1" modified="2016-09-07" version="1">MIDLHCDTAARLYYEGGKLSENKYSVDIMKLKKGGVNAQVFANFIDMNNCRNPYEEFLNMYNNFLKELDENKESINIVTNIKELEKVNNEGRIGAFLSIEEGEVLEGKVERVKKIYDLGIRIITLTWNFPNKIGYPNIDFLYKDKGLTPCGREIVAEMERVGIIPDVSHLSDKGFFDVLEICKKPFIASHSNAREIKNHPRNLTDNMIRKLSERGGVMGMNFCSNFLGEYEISRLDDIVRHIDYIKNVGGIDVIAIGSDFDGISNKVEIEDISKMDMLAYRLKDKGYKESEIDKIFSKNALRVFNEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KT51</accession>
    <name>A0A174KT51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppC_4</name>
        <name evidence="7" type="ORF">ERS852471_03041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268027.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12430">
        <property type="protein sequence ID" value="CUP12430"/>
        <property type="gene ID" value="ERS852471_03041"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="152"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="355" mass="39114" checksum="84752B79340E7A9F" modified="2016-09-07" version="1">MSNVVARDIELDFLDDDFELVGSENVATIDTTYASQPYWKDVLSRFVKNKGAIIGLICIVLIIFMAVIGVGLNEHTYDSQIIAHQNLAPRIPGLEKLGIFDGSEKMTTSSGVVEVNKYVSANGSVTGLEDTYYWFGTDVLGRDIFTRTWMGTRISLYIALVAVLIDMLFGLSYGLISGYFGGAIDNAMQRFAEILNGIPNLVIVTLLIIVLKPGLLTITFSLMITGWIGMSRIARAQVLKLKEQEFILASRTLGARNFFIIFKEILPNIFGQIITNTMFSIPNAIFTEAFLAFIGLGVPAPMASLGSLISEAFKSFTTHPYMIIPPVVVLALLMLSFNMLADGLRDAFDPKMKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTV9</accession>
    <name>A0A174KTV9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">arlS_3</name>
        <name evidence="8" type="ORF">ERS852471_03060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268061.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13258">
        <property type="protein sequence ID" value="CUP13258"/>
        <property type="gene ID" value="ERS852471_03060"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="201"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="418" mass="47668" checksum="8C828AB92C7D1D08" modified="2016-09-07" version="1">MNKVKKNKNVTSIAIKLNAISVRDLFLKFLILNACLMFVLIVIWCMDSEKSFFGEVVQNAQRHIDFYPIETATYTVIWDNGKTLVKDASNFLYTVRKIFIVLVIIQGIFLVEEIIFGTARVRKRLKPLNDIAETASRLSNMAFDEEKFHSLEDAIANISPVTSDERIHIGDSELQGLEDAINKLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKNDEEVLEESITAIKSESENMKNLVEQLLFLARGINGKTQLTMTEFLLNDMISEVFEESKMIDENHIYTYINSENISIKGDIGLLKQTARILVENAAKYTESGEEIMLKVGRNHKGEPYFSVQDNGIGIDAEDVPHIFERFFRADTARVRKNGGTGLGLSIAKWIIDNHKGYFSVLSRKEIGTRVTVYLPQIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KU48</accession>
    <name>A0A174KU48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated Cas5e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268075.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13577">
        <property type="protein sequence ID" value="CUP13577"/>
        <property type="gene ID" value="ERS852471_03067"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1424702at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="232" mass="27126" checksum="16DBDF9EDD0AC1B1" modified="2016-09-07" version="1">MEFRVYEISVKNYLLKNIDKNNMFQAISEVIDSTLSRNEEFLEFHNKNCYKNYCNNGFYPLETDGIYKEDNIYTFQIRTIDEDLAKYLIKNLANTSTKFIKVLKTDIKIISRKHIDKVFSITPIVIKDSTGYWKGNISLDEFENRIKTNLIKKYNSFTGDKIDEDFEFYTRFEFKNNKPIAVNYKNIKLLGDKIQLNIADDEISQTIAYIALGTGLGENNSRGAGFIGFRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KWC7</accession>
    <name>A0A174KWC7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268111.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14756">
        <property type="protein sequence ID" value="CUP14756"/>
        <property type="gene ID" value="ERS852471_03085"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741006at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="16336" checksum="1840343E4AD5EC81" modified="2016-09-07" version="1">MIKVKIDKNKRGEPIFKLGYKELDDKELRFLKRAIMEGKEIKGMFKYEIPLRFFIPIFNNIDKDNIKVDRYSKVEFLEFSDFYDEKYFYSFEVTPKYMKKWREEGCPNIFKIQIDKDSMEIKKEIIFKKISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LMQ3</accession>
    <name>A0A174LMQ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25393">
        <property type="protein sequence ID" value="CUP25393"/>
        <property type="gene ID" value="ERS852471_03280"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1638105at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP25393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="147" mass="16948" checksum="4E7D622D1E30CB85" modified="2016-09-07" version="1">MIRTVVCEKEGCSGNTFFIETDNNNLKLTCKNCGSQYEIDISYYDFTMLSNCSKCNNDTFKVFRDLDKEGVYVKCAECGSTPEKIYIDSDGVQVSYEIKLLSDIKEVMYLIEQRVCNLEMRIQDLERGQSTIEESLAYVNKYLIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M0C9</accession>
    <name>A0A174M0C9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chain length determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cap8A_6</name>
        <name evidence="9" type="ORF">ERS852471_03312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000043">
        <property type="protein sequence ID" value="CUP27445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27445">
        <property type="protein sequence ID" value="CUP27445"/>
        <property type="gene ID" value="ERS852471_03312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP27445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="24969" checksum="D0F57479AE563278" modified="2016-09-07" version="1">MGELKLGKIINALKSNFRLILISTLSVTLVSSIVTFFFVLPKYEASSKVYIGKEKFKNVSTTYSNDEVTMYQKLIKTYAEIAKTKNLMAKAIKNVGEDITVAEALRKVQVVPIADTQILQFKYVSSSREESYNMIYGLTEEFMKLSKSLYPNGNVHIIEQPKVPQGTVSPNKTMNIAIGAILGIMLGVGIVILKEYMNNSFNDKEEIEEFLQVSCLGVIPNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDG5</accession>
    <name>A0A173XDG5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ureA_1</name>
        <name evidence="4" type="synonym">ureA</name>
        <name evidence="6" type="ORF">ERS852471_00011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262684.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49350">
        <property type="protein sequence ID" value="CUN49350"/>
        <property type="gene ID" value="ERS852471_00011"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826954at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="100" mass="11305" checksum="DD041B03E1F02343" modified="2016-09-07" version="1">MRLSMKEQEKLMIVVAADVARRRLAKGIKLNYPESVALITDEIMEGAREGKSVELLMNEGRQVLTREQVMEGIPEMIHTIQVECTFPDGTKLVTVHDPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJ58</accession>
    <name>A0A173XJ58_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmB</name>
        <name evidence="6" type="ORF">ERS852470_01423</name>
        <name evidence="5" type="ORF">ERS852471_00320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834855</strain>
            <strain evidence="5 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZV01000013">
        <property type="protein sequence ID" value="CUO09385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005213497.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="84024.ERS852471_00320"/>
    <dbReference type="EnsemblBacteria" id="CUN67513">
        <property type="protein sequence ID" value="CUN67513"/>
        <property type="gene ID" value="ERS852471_00320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09385">
        <property type="protein sequence ID" value="CUO09385"/>
        <property type="gene ID" value="ERS852470_01423"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000095558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN67513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO09385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7091" checksum="49BC48E45521F4C1" modified="2016-09-07" version="1">MARRCEVCNKGVVSGTQYSHSHRQSKRTWAPNIKRVKALVNGTPKTVHVCTRCLRSGKVERAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XL94</accession>
    <name>A0A173XL94_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52423">
        <property type="protein sequence ID" value="CUN52423"/>
        <property type="gene ID" value="ERS852471_00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="200" mass="23744" checksum="BF42726F287DACF4" modified="2016-09-07" version="1">MEDKLIMNKHCEERFRNIKEAVDELIANSDKDVLVIGIDGKCASGKTTLGYYLNKLYDSNLFHMDDFFLQNHQRTEERLSEVGGNVDYERFKEEVLDNILEKKDVNYRPFSCMERKIKDGYIVSQKRINIIEGSYSLHPYFNNCYDLKIFTDISDEKQLENIEKRNGPKQLIKFREEWIPKENAYFEKFNIKNGCIIVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLV6</accession>
    <name>A0A173XLV6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)</fullName>
            <ecNumber evidence="2">1.1.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hsdA</name>
        <name evidence="2" type="ORF">ERS852471_00073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.50" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262782.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52912">
        <property type="protein sequence ID" value="CUN52912"/>
        <property type="gene ID" value="ERS852471_00073"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047042">
        <property type="term" value="F:androsterone dehydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="29833" checksum="3EF3C6CB121711AE" modified="2016-09-07" version="1">MKDVMIMTGAGQISMAIARRIGYGMKIIIGDKNPQNANTISKIVNDTGFDTVAFEMDLSSRESILDLIREAQKYGEISMLVNGAGVSPSQASIEDILKIDLYGTTVLLEEVGKVIKKGGVGVTISSQSGHRMPALSAEVDEQLATTPTERLLDLEVLQKENIKDTLHAYQMAKRCNQKRVMAESVKWGKRGARINSISPGIIVTPLAIDEFNGPRGDFYKNMFAKCPAGRPGTADEVANVAELLMNPKGAFITGADFLIDGGATASYFYGPLKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMZ0</accession>
    <name>A0A173XMZ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease, Z1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262788.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53094">
        <property type="protein sequence ID" value="CUN53094"/>
        <property type="gene ID" value="ERS852471_00076"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323445at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018310">
        <property type="entry name" value="Put_endonuclease_Z1-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10593">
        <property type="entry name" value="Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Z1" evidence="1">
        <location>
            <begin position="285"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="704" mass="80675" checksum="F1E57C1E334B3477" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQ15</accession>
    <name>A0A173XQ15_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262817.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53824">
        <property type="protein sequence ID" value="CUN53824"/>
        <property type="gene ID" value="ERS852471_00093"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1871431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="16671" checksum="C6CBAEB1EC9A9002" modified="2016-09-07" version="1">MNKDKLKKLLYDMESENKDIEESLKLLDSYSENELLKKEITNSLKYKYLSMFILYEDFITMLLKEYNLYKIGITVDSAIKILNEKNVLSEELSNYLNSARLLRNRIGDRYKQPKVETLISFLNENVEIRNSLYLFIKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWB9</accession>
    <name>A0A173XWB9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262853.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54728">
        <property type="protein sequence ID" value="CUN54728"/>
        <property type="gene ID" value="ERS852471_00113"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1960356at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="203" mass="23416" checksum="1E9E127CDC4698C4" modified="2016-09-07" version="1">MTKRKKRKKSFCEDFDRFKLPPCAKFLGSNNPFVKDGKIIYRNNNRLYLFLSFNTKSNVGKTYNPMDPSTYSSTGVGNLQIELYFFIIGLFINEVQKGNIKDYENISIHEDDNADKFIKNVLDNEYNITTEFVPSLTYLISNASAVIPVFTGVIDISPINFYIILMLSRFYGDYGLLFSDNAYVTNDFINLALANTYVEFYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XYW9</accession>
    <name>A0A173XYW9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">plsY</name>
        <name evidence="11" type="ORF">ERS852471_00142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262910.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56196">
        <property type="protein sequence ID" value="CUN56196"/>
        <property type="gene ID" value="ERS852471_00142"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN56196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="196" mass="21233" checksum="80CF2699B6CC72ED" modified="2016-09-07" version="1">MLALLIIFSYLMGSIPSGYIIVKKKLNKDVRDYGSGNIGATNVGRVAGKKIGKITAILDMLKAIVPVVLTQILLANNILTTNKSLSLGLVALAAILGHNYTIFLKFKGGKGVATSAAAFMFIVPKAFIVTAIVFFGLKLFTKIVSIRSLTAAVVLCTSTWLFGYDKYLIISTFIAAALCFWRHRANIKRLIDGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAD9</accession>
    <name>A0A173YAD9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_3</name>
        <name evidence="6" type="ORF">ERS852471_00231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263071.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60844">
        <property type="protein sequence ID" value="CUN60844"/>
        <property type="gene ID" value="ERS852471_00231"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN60844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="335" mass="37508" checksum="403EA1EF1A615739" modified="2016-09-07" version="1">MGKVLLEVDNLKTKYITRFGEDVYAVDGVSLKIEEGKSLGIAGESGCGKSTLALSLMGYYFAPLHYQSGSIKVDGKDISIMKPDDVRKKILGNEIAYIPQSAMNALNPTQKIIRFIEDVIRAHDPKAKKNDIYDLARKRFEILGLPESVLQKHAVELSGGMKQRTVIAISTILSPKVLIADEPSSALDVTSQKMVIKMLKDLMHKGFIKSMIFITHELPLLYNVTDDIMVMYSGQIVEYGKAKEMVFDPMHPYSKGLMGSIIVPEEGTKNNKLVAIPGTPPNLKNPPLGCRFAERCKFSKPECMVHSIDEKYIENGRMYKCYMNESELREVYSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YE32</accession>
    <name>A0A173YE32_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">selD</name>
        <name evidence="8" type="ORF">ERS852471_00239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263087.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61396">
        <property type="protein sequence ID" value="CUN61396"/>
        <property type="gene ID" value="ERS852471_00239"/>
    </dbReference>
    <dbReference type="OrthoDB" id="882590at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="166"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN61396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="345" mass="37405" checksum="A922CD4C1D79412B" modified="2016-09-07" version="1">MSNNIKLTTLTKTSGCAAKIGPAVLDSVLKNLPQFEDPNLLVGFDKKDDACVYKVSDDKVVIQTVDFFPPMVDDPYTFGQVAATNALSDVYAMGGDPALAMNLLCFPSCLNPSIMHDILQGGYSKIKEAGAVVAGGHTIADPTPKYGLCVSGFAHPKDILTNSNAKTGDVLVLTKPIGVGILNTANKAELLTQDKIKEVTNIMTTLNKYAKESFKGLTVHACTDITGFSLIGHGYEMAGGSNKTIELFSNNIPIIPDALEYAKMGILPEGMYNNLEYLKDIFRITNGVTQEMQDVLLDPQTSGGLLLSMPEKDAKEYLSRMEIYTPYTRIIGQVIDKQDYSIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWM1</accession>
    <name>A0A173YWM1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rlmN</name>
        <name evidence="13" type="ORF">ERS852471_00314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263247.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67168">
        <property type="protein sequence ID" value="CUN67168"/>
        <property type="gene ID" value="ERS852471_00314"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="96"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN67168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="38962" checksum="BD171964642D176C" modified="2016-09-07" version="1">MENLLDFTLEELQNWMKENGESAFRAKQVFSWIYNEVWDYDDMKNIPNSLKHKLKDNFYIGIPKIEEVYESSLDGTKKMLLRFRDGNIIESVIMQYKHGNSICISTQVGCRMGCKFCASTLGGRVRDLTCGEILAQVIIGKKVCGDRISNIVLMGSGEPLDNFDNVMKFLKLVNADYGLNIGQRHITLSTCGIVPKIIELADKEMSITLAISLHAFSDEKRKEIMPIANKYTISEILDSCRYYIEKTGRRITFEYSLVSGVNDSKEDARSLGRILKGMLCHVNLIPVNEIKENTLKRPSKKVIEEFEEILKNNGIEVTVRREMGADINAACGQLRKSYIESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWR1</accession>
    <name>A0A173YWR1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">ERS852471_00318</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263255.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67405">
        <property type="protein sequence ID" value="CUN67405"/>
        <property type="gene ID" value="ERS852471_00318"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN67405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="215" mass="23517" checksum="8CE3B163F29D55B0" modified="2016-09-07" version="1">MIKIAPSILSADFSKLGEDIEKLHNAGADFIHIDVMDGRFVPNISFGMPIIKAIRNRTDKVFDVHLMIEEPSKYIDDFIAAGADLITIHYEAEKHIDRAIQYIKSKGVKAAVALNPGTPTTVLKDIISELDMVLIMSVNPGFGGQKFIKYSIDKIKEVKAMSEKVNKDLLIQVDGGIDPSNVLDVIEAGANVIVAGSAVFKNGEIEKNISLLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z111</accession>
    <name>A0A173Z111_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein ERS852471_00349</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263305.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69136">
        <property type="protein sequence ID" value="CUN69136"/>
        <property type="gene ID" value="ERS852471_00349"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="14749" checksum="A7F99BD09FAFB94E" modified="2016-09-07" version="1">MNNYNKNIGNYGENLASKYLINLNHRILEMNYRNRLGEVDIISTINDIIIFTEVKSRYTNSYGLPVESVTYYKQRQIIKVSSYYILINKLNKYNIRYDVIEVLFNKFNQDFAINHIKDAFRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z399</accession>
    <name>A0A173Z399_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accB</name>
        <name evidence="4" type="ORF">ERS852471_00377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70754">
        <property type="protein sequence ID" value="CUN70754"/>
        <property type="gene ID" value="ERS852471_00377"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN70754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="17535" checksum="9AE504483B61D863" modified="2016-09-07" version="1">MLDYNKIKELIHEIDSSSIRVFELENDGFKLKLSKNDEVSFKEINNKEEVNVGNTNSKSIPKKELVVEEESNNIIDIELKEVKSPLVGTFYSSSTPGGKPYVEVGSKVKKGDVLCIVEAMKIMNEITSDFDGEIVEVLRKDEDIVEFGMNIFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z3B8</accession>
    <name>A0A173Z3B8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridylate kinase</fullName>
            <shortName evidence="10">UK</shortName>
            <ecNumber evidence="10">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Uridine monophosphate kinase</fullName>
            <shortName evidence="10">UMP kinase</shortName>
            <shortName evidence="10">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pyrH</name>
        <name evidence="12" type="ORF">ERS852471_00356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263318.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69588">
        <property type="protein sequence ID" value="CUN69588"/>
        <property type="gene ID" value="ERS852471_00356"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="10">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN69588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="236" mass="25596" checksum="F0AAC36D50BF90CC" modified="2016-09-07" version="1">MEKCAYKRVMLKVSGEALSGENGFGFDFETVGRIAREVKSLVDMGVEVGLVVGGGNIWRGRTGEGMDRTTADHMGMLATCINALALQDALEGIGVLTRVQTAIEMKEIAEPFIRRRAVRHLEKGRVVIFGAGSGNPYFSTDTAAALRAAEIEADVILLAKNVDGVYDKDPNKFADAKKYDKLTYMEVIEQGLQVMDTTATTLCMDNNIPILVFGISDEGNIKRAIKGEKIGTIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z535</accession>
    <name>A0A173Z535_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rubrerythrin</fullName>
            <ecNumber evidence="6">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbr1_1</name>
        <name evidence="6" type="ORF">ERS852471_00390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263379.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71451">
        <property type="protein sequence ID" value="CUN71451"/>
        <property type="gene ID" value="ERS852471_00390"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN71451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="22374" checksum="0B12A276CFBBA35E" modified="2016-09-07" version="1">MLKGTKTAENLLKSFAGECQARTRYTYYASTAKKEGYVQIANIFMETAEQEKEHAKRFYKFLKDEFADEAIEITASYPVALHGETVKNLKAAANGEHEEWSADYPEFARVAREEGFLDIAIAYERISEVEFRHEKRYRKLLENIENDSVFKKEESVLWKCNNCGYIYEGNEAPKACPACLHPQGYFEVFIENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGK5</accession>
    <name>A0A173ZGK5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263513.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75257">
        <property type="protein sequence ID" value="CUN75257"/>
        <property type="gene ID" value="ERS852471_00465"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TM1586_NiRdase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="23148" checksum="05CDA84B6A654502" modified="2016-09-07" version="1">MEIFEAMKKRHSVRSYTSEKIDTNVAKELELYIDECNKESGMNIQLCLSEPNAFNSFMAHYGSFKNVNNYIAIVGKKGKDFEEKCGYWGEKIVLKATQLGLSTCWVAMTYSKGKAKYNIEKGEKLSCVISLGYGESEGVPHKNKSIESLCTVDREMPEWFKKGMEAALLAPTAMNQQKFHFTLEGNTVTAKAGMGFYTKLDLGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGY3</accession>
    <name>A0A173ZGY3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore cortex-lytic protein</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lyc_1</name>
        <name evidence="2" type="ORF">ERS852471_00458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74890">
        <property type="protein sequence ID" value="CUN74890"/>
        <property type="gene ID" value="ERS852471_00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="341"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="439"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="528"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="598" mass="66123" checksum="0EB87DE7F05AB796" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZWG5</accession>
    <name>A0A173ZWG5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mur ligase</fullName>
            <ecNumber evidence="4">6.3.2.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cphA_1</name>
        <name evidence="4" type="ORF">ERS852471_00507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79989">
        <property type="protein sequence ID" value="CUN79989"/>
        <property type="gene ID" value="ERS852471_00507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071160">
        <property type="term" value="F:cyanophycin synthetase activity (L-aspartate-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="3">
        <location>
            <begin position="172"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="2">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="564" mass="64070" checksum="017617652CF559BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYZ0</accession>
    <name>A0A173ZYZ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptaprenyl diphosphate synthase component I</fullName>
            <ecNumber evidence="2">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.30" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263641.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81652">
        <property type="protein sequence ID" value="CUN81652"/>
        <property type="gene ID" value="ERS852471_00527"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2030916at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014535">
        <property type="entry name" value="Hpre_diP_synt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027391">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="164" mass="17752" checksum="F4E68F8CE3171C38" modified="2016-09-07" version="1">MSKTKRLIYLALLTSMAIALQVFESMIAVPLPYGAKLGLANIIALVTMELFDVKELILVNSMRVLLGSLLRGTFLTSTFWISSGGVLLSSLAIIFMKKFTKQSMIGISIISAVFHNIGQIIVITFLYNNVALAAILPILFITAIPTGILVGIAAKETSSRVKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZD7</accession>
    <name>A0A173ZZD7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
            <ecNumber evidence="3">2.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mdoC</name>
        <name evidence="3" type="ORF">ERS852471_00518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263626.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80999">
        <property type="protein sequence ID" value="CUN80999"/>
        <property type="gene ID" value="ERS852471_00518"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN80999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="363" mass="41675" checksum="4C51AE80CF481D8D" modified="2016-09-07" version="1">MRRNEIDWIRNICILMLFVYHTAALFTDFGDFYVKAENSNLFSNIFILLTFSWYMPLLFFLAGASTYFALKKRSGGQYIKERVKRLLIPFIFGILVVVPPQTYLARLWRGEKNINYFSHLKMFFTNVSDFMGFDGNFSPAHLWFIIFLFAISVVGVLIIKWLKTKPGKFISDSIKPIVLGKRSLLWVLIALITLEMIPTIGGKGVLTNLLLFILGYVAYSDNEVIERLSNKRRLFLALTIGTVMLGALYFFLIRNAQTESIVYILDSTLKSTISLIMGITIVSYGIRYLNKSNKLLAYLNKASFPVYILHQTILLVLAFYILPLTLPAWVSIVLIISLSFGLTFIAYEICRRIKFMDVLLGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZT1</accession>
    <name>A0A173ZZT1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263630.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81139">
        <property type="protein sequence ID" value="CUN81139"/>
        <property type="gene ID" value="ERS852471_00520"/>
    </dbReference>
    <dbReference type="OrthoDB" id="967747at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="2">
        <location>
            <begin position="107"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="432" mass="47265" checksum="9D081439372C7D63" modified="2016-09-07" version="1">MDNNIAPQTNEVVVKPTSKRKKILFFAVLAVLVLVGFTAAYTNSENKKLVNSYEDKVYPGTFVLDTDVSGFTKSQLHNVLEEMVNEISSRKINVAVGDSNFDKSYLNLDTTIDYETFENELLNFGKDKNFKEKLSLIKEPESRSYEFEILYNEDKIAEFIDTIAEQVKVDAVNASISISWDTISVTDGQVGYGLNKEELFTNIKTALEDVNGDDLVSIEGNLEEVDPEITTAALQTVDTKISSYTTYFSAGPSGTNIQRGASMIGNVLLMPGDSFSTVEAIGPTTAENGFVAANTYLNGKVVPGYGGGVCQISSTIYNAELRAGIIPDFRTYHEMTVGYVPQGLDATIGDEWPDLVFTNPYDYPIVVNVYSSGGSITAEFWSNSQATGGITYEPKAYQTGALSADTYLYGYNSAGECVSEVYLDSSVYKPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A116</accession>
    <name>A0A174A116_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component sensor histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">graS_2</name>
        <name evidence="5" type="ORF">ERS852471_00535</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852471_00535"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="126"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="39263" checksum="BABEF2B845B08E98" modified="2016-09-07" version="1">MNIVDFFKERILFIALNIVILIFTAVLLISLKVDMYAIVFIFIINLIGILIFHFYEFFRKKRYYDEIEKDLQSLDKKYLLSEVVAESDFLEGKLIHNIIDQANKSMNDEISKYKLSIDEYREYIEMWVHEIKTPIATCKLLIENNDSKITRSIGEELGRGEDYIEQSLYYTRSNVLEKDYIIKEINLSDSINNVIRKNANTLIAKRIKINIYDVDKKVYCDSKWIEFILNQIISNSIKYMNKKESELKVYCEKFNEDVILNICDNGIGINEKDRVKVFEKGYTGENGRIFGKSTGIGLYLCKKLCIKLGLGIKLESEELVGTKVSIIFPINNLMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6P3</accession>
    <name>A0A174A6P3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pectin methylesterase</fullName>
            <ecNumber evidence="10">3.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pemA</name>
        <name evidence="10" type="ORF">ERS852471_00558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263695.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83843">
        <property type="protein sequence ID" value="CUN83843"/>
        <property type="gene ID" value="ERS852471_00558"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1095798at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="9">
        <location>
            <begin position="1302"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1262"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN83843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1334" mass="144709" checksum="94F3C68BD6C90AC7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHW4</accession>
    <name>A0A174AHW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superfamily II helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263775.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87066">
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        <property type="gene ID" value="ERS852471_00600"/>
    </dbReference>
    <dbReference type="OrthoDB" id="964403at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040538">
        <property type="entry name" value="Cch_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009270">
        <property type="entry name" value="DUF927"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06048">
        <property type="entry name" value="DUF927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18662">
        <property type="entry name" value="HTH_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF927" evidence="1">
        <location>
            <begin position="107"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_56" evidence="2">
        <location>
            <begin position="511"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN87066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="636" mass="72112" checksum="8966D50206C5411B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJP1</accession>
    <name>A0A174AJP1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium/proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263791.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87666">
        <property type="protein sequence ID" value="CUN87666"/>
        <property type="gene ID" value="ERS852471_00608"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="NhaP"/>
    </dbReference>
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        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="286"/>
        </location>
    </feature>
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        <location>
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            <end position="317"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="395"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN87666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="472" mass="51400" checksum="2C2E644C768FBC18" modified="2016-09-07" version="1">MMNTLMICGLVLLISITTSKVLYKFGVPILLIFIVLGMLFGSDGIVGIYFANYNLTNEICSIALVLIMFYGGFGTNWKVAKPSLKPALLMSTGGVIITTLLTGTFAYFILKVSILEGLLIGAVVSSTDAASVFAILRSQKLNLEGSLASLLEVESGSNDPTAYMITISILTIMSSGAVNGIILIIIKQIIFGVLIGVILAKIAVFVLRNVDFEIRGFDSIFITAIAILAYAVSEWLGGNGYLSVYLAGVIIGNSKIPHKKNLFYYFDGVSWIMQIALFFLLGLLAFPSKFPQVIGISIAISIFLIFIARPAATFLILKPFGYSTREKLFVSWVGLRGAASLVFAIYAMTYGVKIENDIFHIIFFVALFSVAIQGTLIPKLAKKLDLVDNSSPVLKTFNDYTGEMSSKLIELNITKESKWVNKIIMDADIPNEILIVMIKRNDEIIIPKGASIIKEGDILVLSGEGIENLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AM92</accession>
    <name>A0A174AM92_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nudC</name>
        <name evidence="8" type="ORF">ERS852471_00626</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263826.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88750">
        <property type="protein sequence ID" value="CUN88750"/>
        <property type="gene ID" value="ERS852471_00626"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1435118at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="149"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="32189" checksum="15BBCA16544FB59F" modified="2016-09-07" version="1">MIQDIEPHKYNSTYGKFEVRSNDYIVAFKENKAILIKDGNEKRIPKYKEVMGVLDGLEHLIYMFTIDEKRFFLALKADVKENEIFVRESIQVFRTMKPQWMAFAGFTSYHLYMWYDTNRYCGRCGSIMAHSDKERSLVCNNCNNIRYPRISPGVIVGIIDGDKMLLTRYAKGPYKNYALVAGYNEIGESLEETVRREVMEEVGLKVKNIRYYKSQPWGLSGSVLSGFFVDLDGDSTITLDKNELAEAIWIKREDIPKPELNISLTKEMIEFFRVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B106</accession>
    <name>A0A174B106_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocating C-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94384">
        <property type="protein sequence ID" value="CUN94384"/>
        <property type="gene ID" value="ERS852471_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="171" mass="18650" checksum="B583024490D4AD3C" modified="2016-09-07" version="1">MLEKLMTSINSGTFTLNNVLIVIATAIVLGLVISLTYIKTHKKEGYVPSFTVTLIMLPVIIAIIILLVGNNVARAFSLAGAFSIIRFRSAPGDPKDLSYVFFTLAVGLATGMGFIGYAVIFTIILCLLMIIIEVTKFAVPKSKALELKITVPENLNYEGIFDEILNKYTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3D4</accession>
    <name>A0A174B3D4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP-loop domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ttcA_1</name>
        <name evidence="3" type="ORF">ERS852471_00686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263952.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94128">
        <property type="protein sequence ID" value="CUN94128"/>
        <property type="gene ID" value="ERS852471_00686"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="55"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN94128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="289" mass="33483" checksum="952967F0790283D7" modified="2016-09-07" version="1">MSGIAGSGCERIIPEEERKSLEEIERSIIKRYRKGIWSKFIKAIKDYNLVEDGDKIAVAISGGKDSLLMAKLFQELHKHSQVKFDLEFIAMDPGYHPQIRELLEENCKHLNIPVNIYETKIFDIIDEKAKEYPCYLCARMRRGSLYAKAREMGCNKLALGHHYNDVIETTMLNVLYAGNFKTMLPKLKADNFPDMELIRPLYYVEEEYIKRFIRYTGLWPLNCACMVAAKKVGNKRHEIKDLIAKLKENFNDVDKSIFKAAANVNMNSILGWEKDGEKYSFLDIYDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5F2</accession>
    <name>A0A174B5F2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263983.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95429">
        <property type="protein sequence ID" value="CUN95429"/>
        <property type="gene ID" value="ERS852471_00705"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1274094at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN95429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="27088" checksum="41F44C8144A96610" modified="2016-09-07" version="1">MDLSQVISFAIIVMCAYFIEGLIGFGGTIMALPIASAIAGLKVTVPVMTIVVLIASVVIAIRDFKYINKKEFIKITSLMVLGLPIGMWLFSSLPERPLKIALGLFMIIVAIRGLYDGRKKVEENVEKIKSRYIGIIHNIVLFLGGIVHGAFTCGGPFVVVYATANIKDKSSFRATLCALWATLNAIMLSINIFRGEITSGIVTMSLITMIFVIVAIVVSNIVHKKIKGDSFTKFVYVALFISGILMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B6G8</accession>
    <name>A0A174B6G8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">moaC</name>
        <name evidence="7" type="ORF">ERS852471_00723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264010.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96542">
        <property type="protein sequence ID" value="CUN96542"/>
        <property type="gene ID" value="ERS852471_00723"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1595361at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="160" mass="17136" checksum="E38FB9631FA98E26" modified="2016-09-07" version="1">MNNGLTHFDNSGNARMVDVSEKIETARCAVAVSKIKVSKETLDLIEAGKIGKGDVLGVARVAGIMASKQTSNLIPMCHPLMISSVNVDFDINKEESAIDITATVKIVDKTGVEMEALTAATVAALTIYDMCKAVDKRMVIEGTHLLKKTGGKSGEFNFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBY9</accession>
    <name>A0A174BBY9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluF_1</name>
        <name evidence="5" type="ORF">ERS852471_00736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264032.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97245">
        <property type="protein sequence ID" value="CUN97245"/>
        <property type="gene ID" value="ERS852471_00736"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN97245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="26103" checksum="B506C64AD2B071C2" modified="2016-09-07" version="1">MRINKLLSNYGVCSRKEANRIIEEGRVIVNGELAFPGQWVEEYDDILLDGEKLKPKERIYIALNKPVGITCTAANDVEDNIIQYMNYPEYIFPVGRLDKLSQGLILMTNNGDLANSILEADNNKEKEYIVTVDKEFDNKFIEGMSNGVDIGGVITRPCKVSRVNDKTFNIILTQGLNKQIRRMSKAFGFNVVRLERVRIMNIKIDGIEYGKWRKLTEDEISVLREHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFF9</accession>
    <name>A0A174BFF9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3D/G5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yocH_1</name>
        <name evidence="3" type="ORF">ERS852471_00784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99752">
        <property type="protein sequence ID" value="CUN99752"/>
        <property type="gene ID" value="ERS852471_00784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018399" evidence="1">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3D" evidence="2">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN99752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="190" mass="20829" checksum="92C0D728FAA46DF3" modified="2016-09-07" version="1">MFKKLFVSLTVITLSALTSFPTFANALSTTVDINNHKFKYNEFKENVDNVEKLNKILKNPTSNDVVEEVSNTDVTVKNIDSSDTTDENNHSGYISNFIMESTAYTGDGITATGTVPTRNEGGYSTIAVDPSVIPLGSLLYIDGYGYAVAEDTGGAIQGNIIDLYLNSHDDCMNWGRRDVSVYLIAYPGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BI57</accession>
    <name>A0A174BI57_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KWG repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264129.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99869">
        <property type="protein sequence ID" value="CUN99869"/>
        <property type="gene ID" value="ERS852471_00786"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1807750at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="481" mass="54918" checksum="BC566C0937F36DF5" modified="2016-09-07" version="1">MKSEVIIDSKNGRVTREEKEDIVCLKGNKINEDSNFIENLCIDIKSDVIGEKEFPLKIGGYNFKLFLGHFCNEYIEDILICGESGGSGNYAIANIYHYQDGKLLEIFNSDTFSDKYKYKCRYLKDCKIELICDKLQKKYIIDIGTIDKNYLEQIYSIDGKIITDSDPSVSYVTDIYPIIDLNTNLMRVEAYQRVIGIVNASTIGEIISIISLEECRTKVIEQFAATDGENISELSRGNDLRDDIISKLPDDITLINLNKFGGRNGLIKADIDGDGNEEILCAYKYKDVQYLSAFREIDGAVKFLDNIDGTGYDISDLIIDKIKQKGGESIIVGWRIGGIWSVLDILDFREGKFIKALKGDKLNYSKIELCDSSNTRGGKNIALWTHETGEAYNVQIYTLRGETLEKTYKDDKEYFLRVEEYYKNLINKSRETPQYLYYLIQAQCRAGKKKEAIDNINRALKNPNPFPSIQELKRLRKSISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNV1</accession>
    <name>A0A174BNV1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264226.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02434">
        <property type="protein sequence ID" value="CUO02434"/>
        <property type="gene ID" value="ERS852471_00834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO02434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="125" mass="14631" checksum="745751AB80581B0D" modified="2016-09-07" version="1">MGRTNIINITKSYLDKRGYNNINFDNGYGVVVFEKVKIFFYPGNEVLRITAIPTDRKYKIYKDFNIEGTSIGNILLKYQPDKSNSELMYDIYEKYVTDSNIDKVAIFFLNNTQDIFNDVESDELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBT0</accession>
    <name>A0A174CBT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.91</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfdA</name>
        <name evidence="2" type="ORF">ERS852471_00956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.91" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264471.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10237">
        <property type="protein sequence ID" value="CUO10237"/>
        <property type="gene ID" value="ERS852471_00956"/>
    </dbReference>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="532" mass="60196" checksum="F2D1A68EE2EED260" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIR0</accession>
    <name>A0A174CIR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF_1</name>
        <name evidence="3" type="ORF">ERS852471_01007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264539.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12827">
        <property type="protein sequence ID" value="CUO12827"/>
        <property type="gene ID" value="ERS852471_01007"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="36981" checksum="D281FC6E54F2FCFF" modified="2016-09-07" version="1">MIVVMNPNVTDSDIDIVKKELESKGLSVHLSQGSTYCIIGIVGDASNIDPDKLLTFDGVDKVLKVQHPFKKANRLFKPEDSIVKVENTLVGGNNLGVMAGPCSVESEEQIIDIAKKVKASGANFLRGGAFKPRTSPYSFQGLELEGLRLLKLAKKETGLPIVTEIMSTDYIDDFVREVDVIQVGARNMQNFDLLKQLGKTNKPILLKRGLSATIEEWLMSAEYIMAGGNENIILCERGIRTYEGYTRNTLDLSAVPVVKRLSHLPIIVDPSHAAGYWYLVEPLAKAAIAAGADGLMIEVHNNPQCALSDGQQSIKPESFDQLMKKIKVLAEMEGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CP63</accession>
    <name>A0A174CP63_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hssR</name>
        <name evidence="9" type="ORF">ERS852471_01030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264566.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15301">
        <property type="protein sequence ID" value="CUO15301"/>
        <property type="gene ID" value="ERS852471_01030"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO15301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="226" mass="26436" checksum="D04A68F250C7F33F" modified="2016-09-07" version="1">MFHILIVEDDKNTRKLMDAIISNDGYKTYTAENGREALEVFDKEHIDLVVLDIMMPEMDGYELTDTLRSCNNNIPILMVSAKQLPEDKKKGFLVGTDDYMTKPIDEEEMLLRIKALLRRSMIINERKLRVGNVVLDYDTLTVSRNDDIKILPKKEFQLLYKLLSYPNKIFTRLQLMDEIWGLESETCANTLNVHINRLRKKFEDYPEFELVAVRGLGYKAVKHEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CU00</accession>
    <name>A0A174CU00_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATPase</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gsiA_6</name>
        <name evidence="5" type="ORF">ERS852471_01053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264587.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16497">
        <property type="protein sequence ID" value="CUO16497"/>
        <property type="gene ID" value="ERS852471_01053"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO16497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="27579" checksum="47F8C0DCDE8A493B" modified="2016-09-07" version="1">MQEVLRVSSIKKTFSKGGKSNTVINEVSFTVNKGQCVGIVGESGCGKSTTARIISGLLDCDEGEISLSGNILSKNSKVRLKEVQGKIQMVFQMPTESFNPRIKLGKSIKEAMSKTLTSVEKEEKLKNLFDECLLQYELADRYPKEVSGGQCQRAAIARALASDPELLICDEATSALDVTVQLNIIKLLKNIQKNRDMAILFICHDIALVQQFCDYILVMDEGKIIEEGTANEIILNPKEVFTKKLISSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVR0</accession>
    <name>A0A174CVR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264573.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15716">
        <property type="protein sequence ID" value="CUO15716"/>
        <property type="gene ID" value="ERS852471_01038"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345242at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO15716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="162" mass="18850" checksum="A0F1A492BBDFCD9F" modified="2016-09-07" version="1">MEYADVYNKDRRKLGKTVLKGDKLTPGEYYLAVHVWIMNSKEQFLIQKRASTVLYNPNKWSLTSGAAIVGEDSYGTCIREVNEELGIEPNMDCAKVMFTLERGDNFCDIWLVQQDINLNECVLQVEEVSEIRWATKKEIFKMIANGEFVPYPYIKRFFEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYR0</accession>
    <name>A0A174CYR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264595.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16898">
        <property type="protein sequence ID" value="CUO16898"/>
        <property type="gene ID" value="ERS852471_01062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO16898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="84" mass="9364" checksum="C420D8E84C23DF1E" modified="2016-09-07" version="1">MRNNKIEKIYEVIKENGRTLNLDEIKSMTEVGNGYNYSNNNTTCAVAVPSHKSQKIYDVVTNISGKINLHTIKAMTGAGNGYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2V1</accession>
    <name>A0A174D2V1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="12">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ERS852471_01123</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264642.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20052">
        <property type="protein sequence ID" value="CUO20052"/>
        <property type="gene ID" value="ERS852471_01123"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO20052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="165" mass="18955" checksum="5518D87A9A79CC0C" modified="2016-09-07" version="1">MNYSQIRKFDVTNGPGIRTTLFVSGCTNNCPECFNKEQQDFNYGQKWDRETEESFLSYVKSPNVVGVSILGGEPMEQTMDSSLVDLLRRIKKETGKSIWLWSGFTYESIIQDEKKKEILECIDVLVDGRFIVAQRNLNLKYRGSENQRVINVPKSLEEGKVISEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7Y2</accession>
    <name>A0A174D7Y2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic ribonucleoside-triphosphate reductase</fullName>
            <ecNumber evidence="5">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrdD_1</name>
        <name evidence="5" type="ORF">ERS852471_01122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264641.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20006">
        <property type="protein sequence ID" value="CUO20006"/>
        <property type="gene ID" value="ERS852471_01122"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO20006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="707" mass="80892" checksum="716FF156684547B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DER3</accession>
    <name>A0A174DER3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsR</name>
        <name evidence="2" type="ORF">ERS852471_01183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264696.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22819">
        <property type="protein sequence ID" value="CUO22819"/>
        <property type="gene ID" value="ERS852471_01183"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="95" mass="11232" checksum="D65212C194989B93" modified="2016-09-07" version="1">MKDKYEVNAKIFKALSDQNRLKIIHILSDGERCACELLNYFNFTQPTLSHHMKVLIDCELVTSRKEGTWNHYSLVEENAKELVDFLNEIIYPERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJT1</accession>
    <name>A0A174DJT1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erythromycin biosynthesis sensory transduction protein EryC</fullName>
            <ecNumber evidence="4">2.6.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eryC</name>
        <name evidence="4" type="ORF">ERS852471_01218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.87" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264737.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25821">
        <property type="protein sequence ID" value="CUO25821"/>
        <property type="gene ID" value="ERS852471_01218"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099620">
        <property type="term" value="F:UDP-4-amino-4-deoxy-L-arabinose aminotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO25821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="41412" checksum="79C2D00211F76D7C" modified="2016-09-07" version="1">MLVPFTSFKAMHGEIRDELVRGFESVLDSQWFIMGEQLKRFEEEYAKFCGTKYCVGVASGLDALRIILMAYGIKEDDEVIVPANTYIATALAVNFVGAKPIFIEPDIKTLNIDSTLIEEKITSKTKAIIVVHLYGRVVNMDDIIKIANKYNLKVIEDAAQAHGAYFKEKRVGNLGDAAAFSFYPGKNLGALGDGGAITTNDKDVANKAYSIRNYGSNKKYYNEIKGLNSRLDELQAALLLVKLSKLDIWTRERREIAEKYYNGIQNDRIKLPLKAKNDENVYHIFPVFCDERDRLKDYLISNGIETLIHYPIPIHLQKAYSELKYKVGDFKITESVSSEELSIPLFIGMKDEEIEYVIGILNKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DPJ9</accession>
    <name>A0A174DPJ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Medium FAD-binding subunit of molybdenum enzyme</fullName>
            <ecNumber evidence="3">1.17.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndhF</name>
        <name evidence="3" type="ORF">ERS852471_01253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264791.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27511">
        <property type="protein sequence ID" value="CUO27511"/>
        <property type="gene ID" value="ERS852471_01253"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050138">
        <property type="term" value="F:nicotinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO27511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="29969" checksum="8EF4BF06684ABEE3" modified="2016-09-07" version="1">MVNGFMATSLKEALEIRSSENVTPYCGGTDLMIENKEGATYLFLNKVPEMKKIVEDNDYIRIGAACTFTEVLNSSIVPKLMKEAVSRIAAPAIRNIGTMGGNIGNGSAKADSVLIEYVSDAKVVVASKDRSRIVPIDEFYKGRKQLDLKKDELIVEILLPKTGLDNYYYKKVGARNALAISRVSFAGIIKMDGDIIKDIAIAFGAISGTVLRFKEVEKLFVGKTLSEAKGMKDKFISEYEKKIVPTKGRVSSEYRKAVCLNLLKDFLTEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DR36</accession>
    <name>A0A174DR36_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="1">2.6.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pabB</name>
        <name evidence="5" type="ORF">ERS852471_01234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264755.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26546">
        <property type="protein sequence ID" value="CUO26546"/>
        <property type="gene ID" value="ERS852471_01234"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="4">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="3">
        <location>
            <begin position="194"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO26546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="456" mass="53109" checksum="FE5579CB34A77357" modified="2016-09-07" version="1">MKFKIEEFSTDLNVFEVYNCVKDNNSILLDSSKEDKDLSKYSFIGLNSFLTFEAYGENSYVNGEKVKGDPFLVLEELIKKYSFKYDIELPLVGGTIGYISYDAGRIIEDIQDFSKEDFKIPDIRFKFYDNIIIFDHMNNKKYITALGIKEDSTESINIIIDKIYKFDKIYKSEDLYNEQVVDKKIDNKFYSNFSKEEYIDKIKKLKEYIRSGDVYIANMTQRFFCESNEDAINIYKNLREINKAPFSVFANYDDFQIISSSPERFIQIKDRKAHTRPIKGTRPRGKDKKEDLLNKEALINSEKDKAELLMVVDLERNDFSKVCKPHTVKVTELFKLEEYATVFHLVSTIEGELKDEISEVKFIRECFPGGSITGTPKIRAMEIIEELEMLKRNIYTGCIGYFDFRGNSDFNIAIRTIIKKENKAYFGVGGGITYDSIEEDEYEETLDKAKALMKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJT0</accession>
    <name>A0A174EJT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage head-tail adaptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265169.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37891">
        <property type="protein sequence ID" value="CUO37891"/>
        <property type="gene ID" value="ERS852471_01467"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1860209at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020812" evidence="1">
        <location>
            <begin position="25"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="362" mass="40682" checksum="F98F6E1571CF315E" modified="2016-09-07" version="1">MKINKSLIVIIMLTISILTGCSKVEDKDDVAINLFDMQKANNIVKDYLNNVISGNFDAANNLLSEELVSSNKNTGEGISKIISFKSDESIEGSNYAYFIYNIVRSSDVEPKSDLENITFKIKKQHNEYKIDEIKSKSEKEIYTKGNGLRVIGEEGGKSSLIISLSNLPKDTYLKDNKIMLYKDIVPKQSFGKVCLSFTGKRIAITTTDNKDSYICIAYIDEALMTSAQPGNEGGNSGASLGTENIDVLEDALEKPIAQKLVTIDLLKDSEVTKFVFSEEEDILQVNYNNKYNKERVRLYKSDNGELIQTELDTMFPEEKYNISNGKFEEDVFKFKVTTSEGQQEALSGEYILDLENLEINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKV6</accession>
    <name>A0A174EKV6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265188.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38443">
        <property type="protein sequence ID" value="CUO38443"/>
        <property type="gene ID" value="ERS852471_01478"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2074291at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="6916" checksum="94A7C9EFA300AEED" modified="2016-09-07" version="1">MKDATIMLRVTAEQKLAIKRTARKLGLTITEFTLLSLMKTISDTETSQNSEVTLDLLSSKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVU1</accession>
    <name>A0A174EVU1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265262.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41427">
        <property type="protein sequence ID" value="CUO41427"/>
        <property type="gene ID" value="ERS852471_01515"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801007at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="37"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="287"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="51449" checksum="8B9C59E3E9C25A5B" modified="2016-09-07" version="1">MNFDVFKDGLIKDYIELNTKSDFDKKFLSLIEVLVIEMMENEDAFFGSFMIQTKRNVDFAIEWPIVTIPVTDGFRMSFNPKSFLSYTKNEMKALIKHEIYHIMFNHYERERDLRQRYDKLAVNIALDISINQFIKNIPMEYTRLHNINMKYNLELQENMSCEYYAEKLHKAINDKKEPLKIDIKDKSDINIKNAHDLWWQSSISQEISRNLAKTVAINSYNGKAPDEIGQIILGYEEKAEISWQKLLKKMIPSLRAGAKKSITRRNRRQPDRLDLKGELPNNIPEILVAIDISASMTDEEINKIMIEILEISKSRGNIITVIECDDEIRRIYKINSIKDIKKRKSNNGSTKFSPVFKYIKSNNMRNVILIYFTDGVGEKELEIRPINKNTIWVLTGKEELSLTKSYGQIKRISKDTVEGTGGSSGLDMLRSTVDEIHVCKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F015</accession>
    <name>A0A174F015_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ORF">ERS852471_01531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265292.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42156">
        <property type="protein sequence ID" value="CUO42156"/>
        <property type="gene ID" value="ERS852471_01531"/>
    </dbReference>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="335" mass="37540" checksum="1E6224D3521FA898" modified="2016-09-07" version="1">MESNIEQKKVIFSGIKPSGDLTLGNYLGAIKNWVSLQNEYDCYYCVVDLHAITVKQKPADLRKRTLEVLAIYIASGIDPEKNTLFIQSHVPAHSEASWLLTCNSYMGELSRMTQYKDKSQKMGESIGAGLFNYPVLMAADILLYNSDLVPVGKDQIQHLELARDIATRFNNTYSPTFTIPEGYVPKEGAKIMDLQDPSKKMSKSEENPNCYILIMDSPEVIKKKISRAVTDSIGIINYSDDQPGVKNLINIICAIKGISPQEVVSSYEGKGYADLKRDVADIIIEELTPVQERVKKLLSDKKYLEEIYRSGAQKASFAANKTLRKMQKKIGLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F289</accession>
    <name>A0A174F289_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactowaldenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">UDP-galactose 4-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">capD_1</name>
        <name evidence="6" type="ORF">ERS852471_01569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265370.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44184">
        <property type="protein sequence ID" value="CUO44184"/>
        <property type="gene ID" value="ERS852471_01569"/>
    </dbReference>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013692">
        <property type="entry name" value="CapD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08485">
        <property type="entry name" value="Polysacc_syn_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_syn_2C" evidence="5">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="352" mass="39723" checksum="6F98447F0BDE1AEB" modified="2016-09-07" version="1">MFKNKVLLITGGTGSFGNAVLNRFIDTDIKEIRVFSRDEKKQDDMRRVIKSDKVKYYIGDVRDLDSINYAMKGVNYVFHAAALKQVPSCEFYPMQAVQTNIEGSDNVFKSCLMNGVERCILLSTDKAVYPVNAMGISKAMAEKAMIARARAAEEGDTVFCGTRYGNVMASRGSVIPLFIELMKQGKDLTVTDPNMTRYMMSLEESVDLVLHAFANGEQGDIFVQKAPACTVLELATALKELFDSNVGIKIIGARHGEKAYETLLTKEEFVKAEDQGNYFRIPSDNRDLNYAKYFTEGEGSRRNQEEYNSDNTNRINVEQVKEMLLKLPYIQSELKKFRVVESKEVENLAETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8J8</accession>
    <name>A0A174F8J8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galF_1</name>
        <name evidence="6" type="ORF">ERS852471_01580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44660">
        <property type="protein sequence ID" value="CUO44660"/>
        <property type="gene ID" value="ERS852471_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO44660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="32928" checksum="3C6264FC1675EE18" modified="2016-09-07" version="1">MGNKIRKAIIPAAGLGTRFLPATKAQPKEMLPIVDKPTLQYIIEECVASGIEEILIITGRNKKSIEDHFDRSVELEMELEKSGKQEMLEMVREISDMVNIHFIRQKEPRGLGHAILCAKTFVGNEPFAVLLGDDVVYNDEKPCLKQLIDCYGEYKTSVLGVQTVDPKDVNKYGIVGGIHIEDRVYKVKNLVEKPSIEDAPSNVAILGRYIITPRIFEILEETKPGKGGEIQLTDALLQLVKEEAMYAYDFEGRRYDVGDKLGFLQATVEYALRKPELRDGFIEYLKSLSDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDW5</accession>
    <name>A0A174FDW5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease, Rne/Rng family</fullName>
            <ecNumber evidence="7">3.1.26.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rng</name>
        <name evidence="7" type="ORF">ERS852471_01643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265509.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48512">
        <property type="protein sequence ID" value="CUO48512"/>
        <property type="gene ID" value="ERS852471_01643"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO48512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="477" mass="55271" checksum="67E23384EA30A5C0" modified="2016-09-07" version="1">MKEVFVLNEEDFLKIAVKENGELVECIVEEHSTDPQIGEIYKGRIKNILPSINSIFIDIGLEKEAYMYYSDELKRVGVKKGQDILVEILKEPIGNKGAKVTHKPSIAGKYAVLTLGSEGIKLSKRITSLEARQKLTTLIKPPRDVEVLFRTDSEEAESEEILKDLEILFKKKEELERKLNYSTHLGKIDSNNLIVRFFSELDNIKTNIICDDKEQIEIIEGFIKNKDNISIKYYEEDISLFDYYGIEKEILKLRHKKVNLPSGGYIVIDKTEAMYVIDVNSGKHTKARDFNKTIFETNMEAAKEIGRQIKLRNLSGIIVVDFIDMRDDKQRPIVMKTLKKSLESDKGNTKIYPFTELDLIQISRRRKGKSIYEYLEEGCKKCKSNGYILKLSYLENLIKNEILRAYRENSISDFYIELDESYEESVKEDLVGFLARIDGLDKEIYLNFIDNLEGYNLEPLIFSSQKENYQSYKIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FP36</accession>
    <name>A0A174FP36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage III sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIID</name>
        <name evidence="4" type="ORF">ERS852471_01705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265615.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51481">
        <property type="protein sequence ID" value="CUO51481"/>
        <property type="gene ID" value="ERS852471_01705"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1848020at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014208">
        <property type="entry name" value="Spore_III_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12116">
        <property type="entry name" value="SpoIIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02844">
        <property type="entry name" value="spore_III_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO51481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="83" mass="9527" checksum="55F7309CACDDF06D" modified="2016-09-07" version="1">MKDYIEERVLEVAKYIIDSKATIRKTAKVFGVSKSTIHKDMTERLPKINPSIAEQTQNILELNKAERHIRGGKATKLKYKAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPX8</accession>
    <name>A0A174FPX8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yvyD</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="4" type="ORF">ERS852471_01692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265597.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50906">
        <property type="protein sequence ID" value="CUO50906"/>
        <property type="gene ID" value="ERS852471_01692"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO50906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="176" mass="20332" checksum="B8B360B9403F6129" modified="2016-09-07" version="1">MRVTVIGKNINVTPALKEMIEKKISKLDRYFTPGVEARATLSVQKNRQIFEVTIPFNGVVLRCEEATDDMYKSIDLVENKLERQIRKQRTKLSRRNNNSLKFVNIEEVALEDEGTTGEIVKTKKFNIKPMSAEEAILQMELVQHDFFVFKDADTNNINVIYKRKDGNYGVLEPDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWS1</accession>
    <name>A0A174FWS1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">prmC</name>
        <name evidence="10" type="ORF">ERS852471_01726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265653.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52535">
        <property type="protein sequence ID" value="CUO52535"/>
        <property type="gene ID" value="ERS852471_01726"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010787">
        <property type="entry name" value="DUF1385"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07136">
        <property type="entry name" value="DUF1385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PrmC_N" evidence="9">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="8">
        <location>
            <begin position="407"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="491"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO52535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="586" mass="66163" checksum="3AD97904B5FD6335" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4K6</accession>
    <name>A0A174G4K6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_8</name>
        <name evidence="6" type="ORF">ERS852471_01774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265750.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55759">
        <property type="protein sequence ID" value="CUO55759"/>
        <property type="gene ID" value="ERS852471_01774"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO55759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="331" mass="37750" checksum="A76F5A2C27FD453A" modified="2016-09-07" version="1">MKAQELVKPIFSVKNVTMDFKVAKKGFFSKKSTIRALNDVSFDLYPGESLAIVGESGCGKSTLCRIAMKFYNPSSGAMFFENENIHELKGEKLKNYRQKSQMIFQDPFSSLNPLQNIYYHLKRPLELYHSSDEETMYKKMDEYLTMVGLTPPKDQGEKFPHQLSGGQKQRAYIARVLAVGADVIFADEPTSMLDVSIRLGVLNLLNKLKRDMKKSFIYITHDIATARYFADRIIVLYAGHMVEWGDVDKVICNPKHPYTKLLVAAAPDPEREEVIDLPVVRDKDTEIRQWTPESKGCPFRTRCPVAKDICASEFPESREIESGQFIRCIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDA0</accession>
    <name>A0A174GDA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methylase</fullName>
            <ecNumber evidence="3">2.1.1.173</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlmL</name>
        <name evidence="3" type="ORF">ERS852471_01837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.173" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265870.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58809">
        <property type="protein sequence ID" value="CUO58809"/>
        <property type="gene ID" value="ERS852471_01837"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1772619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052915">
        <property type="term" value="F:23S rRNA (guanine(2445)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="385" mass="43681" checksum="F7601EEDF496AB54" modified="2016-09-07" version="1">MEYNLVATTTFGLEGITAKELKALGYEDLKTENGKVHFVGDEMDIAIANVHLRTADRVFIKMAEFEARTFEELFQGTKKVKWSEIIPKDGVMHVVGKSVKSTLFSVPDCQSIVKKAIVTSMSESYGIDKFEEDGPVYKIEVSILKDVVTLSIDTSGVGLHKRGYREEAGIAPLKETLAAAMVLISRWRGNYPLVDTFCGSGTILIEAAMIAQNIAPGLCRNFVSETWPTIGSEIYEQVKEGAERSIKHNDIKLIGYDIDGRILRVARSNAEKAGVSKYIEFQKRDFREFKTSDKNGFIITNPPYGERLGDKDEVGELYRIFGEYKKIHNTWDFNILTSFENFERPFARKASKNRKLYNGKIKCYYYQYFDNTLIKNDGDMLINHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEE3</accession>
    <name>A0A174GEE3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage V sporulation protein D</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsI</name>
        <name evidence="4" type="ORF">ERS852471_01852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265898.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59498">
        <property type="protein sequence ID" value="CUO59498"/>
        <property type="gene ID" value="ERS852471_01852"/>
    </dbReference>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011927">
        <property type="entry name" value="SpoVD_pbp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02214">
        <property type="entry name" value="spoVD_pbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="606"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="668"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="731" mass="79850" checksum="9675875B2605EF53" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFA9</accession>
    <name>A0A174GFA9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265962.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61103">
        <property type="protein sequence ID" value="CUO61103"/>
        <property type="gene ID" value="ERS852471_01891"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2032801at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="83" mass="9499" checksum="5DC3F68060A30411" modified="2016-09-07" version="1">MSKTPLKKIIKSKLKSNKELTPEELLREKIKYEIADELGLKEKVDEYGWAGLTAEETGRIGGIMTKRKKELKIPTNDEILGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHN7</accession>
    <name>A0A174GHN7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase U32</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbU_3</name>
        <name evidence="2" type="ORF">ERS852471_01876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265938.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60506">
        <property type="protein sequence ID" value="CUO60506"/>
        <property type="gene ID" value="ERS852471_01876"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="1">
        <location>
            <begin position="375"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="784" mass="89570" checksum="1839A84C3AFCF87C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GK16</accession>
    <name>A0A174GK16_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP:corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">btuR</name>
        <name evidence="1" type="ORF">ERS852471_01896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61310">
        <property type="protein sequence ID" value="CUO61310"/>
        <property type="gene ID" value="ERS852471_01896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="178" mass="20085" checksum="1986C5E0E6B5EB13" modified="2016-09-07" version="1">MKLEKGLVQVYTGNGKGKTTASIGLGIRAYGNGLKVIMIQFLKSGITGELNVLNNLGENFKVYRFEKEKDFTWNLTDEQKEELKKEITEGFDFAKKVVKEDLCDMLILDEVMASVNGGYIKEDDVVKLIENKPENMEIVLTGRNVPKSIADKSDLITEMKDIKHYFNKGVPARKGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GNL3</accession>
    <name>A0A174GNL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptidase type I</fullName>
            <ecNumber evidence="6">3.4.21.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lepW</name>
        <name evidence="6" type="ORF">ERS852471_01942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.89" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64003">
        <property type="protein sequence ID" value="CUO64003"/>
        <property type="gene ID" value="ERS852471_01942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="5">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="21061" checksum="F395195241F6E017" modified="2016-09-07" version="1">MSSVFNLRIKISNTVWSFVLICAISYLISSYNVYKGEEVIPNILGMYGFTISTGSMEPTINAGDYLVAKKVKSDDIKVGDIITFVEENIIITHRVSGIINNQYEEIMFITKGDGNNVEDDISIMSENIVGKYVFKIPMLGYVLDYFKYMNPMIKVGILLLMYLIYLNIGKEKNIKQEEQYEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPI3</accession>
    <name>A0A174GPI3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-galactose phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wcaJ_5</name>
        <name evidence="4" type="ORF">ERS852471_01954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266080.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64484">
        <property type="protein sequence ID" value="CUO64484"/>
        <property type="gene ID" value="ERS852471_01954"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO64484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="23135" checksum="CDE5AE024F3B2E06" modified="2016-09-07" version="1">MLIKRVFDILVSILLLFFLWPLMLIIYLSVRISLGSPAFFLQERVGKDNKVFKIIKFRTMKDAKDKYGNDLPDFERATRLGIFLRATSLDELPELINVIKGEMSLVGPRPLLKQYLGVYNEEQIRRHEVLPGVTGWAQINGRNSLTWNEKFELDVWYVDNRTFLLDLKILFLTVYKVLKRDGINQGEGVTMEYFNGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVH6</accession>
    <name>A0A174GVH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
            <ecNumber evidence="2">4.1.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fucA</name>
        <name evidence="2" type="ORF">ERS852471_02006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.17" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266175.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66523">
        <property type="protein sequence ID" value="CUO66523"/>
        <property type="gene ID" value="ERS852471_02006"/>
    </dbReference>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="259" mass="28392" checksum="89D20656BE0C6EB5" modified="2016-09-07" version="1">MFSEYEIKKQICEIGKRIYQNGFVAANDGNISVRINDKEVLCTPTGVSKGYMTPDMICKVDMNGNVLQANGKFKPSSEVKMHLRVYKERPDVKSVVHAHPPYGTSYAIAGIPLDKPIMPEAVIALGAVPIAEYGTPSTEEIPDAVAKYLQCYDAVLLENHGALTYGPDLMAAYFKMESLEFYAKLMFISSQIGQPQVLDNTQVDKLIDIRKAMNLTGKHPALCQKGGACTCKANNEEPAVDEDLIAKIAKEVTSKILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZ79</accession>
    <name>A0A174GZ79_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266236.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68102">
        <property type="protein sequence ID" value="CUO68102"/>
        <property type="gene ID" value="ERS852471_02032"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="157" mass="18047" checksum="A29531B49CC61DA2" modified="2016-09-07" version="1">MKKLVVYYSHDGSTKFVAETISKIIEADIMELIPEENINITGIMKISWGIRQLFIHPKPKLLRNNINPSDYDLIVIGTPVWSYTFSPPIRTFFNEYKLSGKKVAIFCCHGGQKGKTIEKMKESLNGNVIIGENDFLEPLKYRREENLKKIIGWANNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCV2</accession>
    <name>A0A174HCV2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMT family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266425.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72732">
        <property type="protein sequence ID" value="CUO72732"/>
        <property type="gene ID" value="ERS852471_02139"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1391352at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="157"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO72732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="294" mass="31989" checksum="04E6BE890E9E0242" modified="2016-09-07" version="1">MWVLYAFASAVFAGTTSILAKMGIKDVDSHVATAIRTIVVLVFSWMMVFVVGSQWTVNDISIKSYVFLILSGLATGASWLCYFKALQIGDVNKVVAVDKSSTILTMILAFIILGEQITINMILGMIGIGIGTYLMIQKKTVNVEDNKQIKGIKNKAWLLYASLSAIFASLTSILAKIGIDNVESNLGTAIRTIVVLIMSWIIVFITKKQHEVKNIDRRSLAFIVLSGLATGASWLCYYKALQDGLASVVVPIDKLSILVTVGFAYIFLKEKLSKKSVIGLGLIVVGTLALLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDR8</accession>
    <name>A0A174HDR8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system lactose/cellobiose-specific transporter subunit IIB</fullName>
            <ecNumber evidence="6">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">licB_4</name>
        <name evidence="6" type="ORF">ERS852471_02146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266439.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72984">
        <property type="protein sequence ID" value="CUO72984"/>
        <property type="gene ID" value="ERS852471_02146"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846001at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023356" evidence="4">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO72984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="100" mass="10734" checksum="AA2023E3E2E059E2" modified="2016-09-07" version="1">MKNILLVCAAGMSTSLLVNKMKDAAKAKGIEININALPVSECSSVVDTVDIVLLGPQVRFQKPQVDALVKGRVPVEVIDMRLYGTMNGAAVLERALQLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDT0</accession>
    <name>A0A174HDT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266371.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71527">
        <property type="protein sequence ID" value="CUO71527"/>
        <property type="gene ID" value="ERS852471_02109"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO71527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="32134" checksum="B5DEDDDD7D7B316A" modified="2016-09-07" version="1">MRFLVFGDSKGKNNGVNTKVLKSIMEQSIKLNPKIDFLVMCGDSIAGSSNKEQLISQFNNFKRIVQSYHPNKIILPVIGNHEVNINPTDDSYEKIFEKIYNDLKPSGYLEDYNKTAYYVDYENTRIIILNAFHPNEIHKIIDNQLSWFENVASVDIKNKLVVVHSPAFPTGAHLGHCLDLYPNYRNSFWQVVDKCKIDIVFSSHEHNYSRRIIHGKNDIHQIITGGGGEKLRDKYKSKDGVIIPPIATYHFVVVDITENFIEVSAINTKGRLLDNFKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIP6</accession>
    <name>A0A174HIP6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lichenan-specific phosphotransferase enzyme IIA component LicA</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">licA2</name>
        <name evidence="8" type="ORF">ERS852471_02142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per trimer.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72839">
        <property type="protein sequence ID" value="CUO72839"/>
        <property type="gene ID" value="ERS852471_02142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00215">
        <property type="entry name" value="PTS_IIA_lac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34382">
        <property type="entry name" value="PTHR34382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000699">
        <property type="entry name" value="PTS_IILac_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared between all trimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO72839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="108" mass="12103" checksum="18CAEBDB7845FB6F" modified="2016-09-07" version="1">MDNMEYQEVVFGLIVNAGNARSKAMNSIRLAKKGKIEEAKENLKLSEEDLNLAHEIQTKLIQGEAAGEKTELSLLMVHAQDHLMNAITVKDLANEIIDIHEKFMIEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HK94</accession>
    <name>A0A174HK94_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic sulfite reductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asrB</name>
        <name evidence="3" type="ORF">ERS852471_02156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266458.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73389">
        <property type="protein sequence ID" value="CUO73389"/>
        <property type="gene ID" value="ERS852471_02156"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014260">
        <property type="entry name" value="Sulphite_reductase_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02911">
        <property type="entry name" value="sulfite_red_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO73389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="29510" checksum="CC045F5B53F5EF06" modified="2016-09-07" version="1">MTNNIYKPFISEILDVIEHTSIEYTFRMAFTGDVKPGQFFEVSLPKYGEAPISVSGIGEGYVDLTIRRVGKVTDEIFKNYKGDKLFMRGPYGNGFDIDNYKGKEVVVVAGGTGLSPVRGIVEYFSRNPQDANGFTLISGFKSPEDVLFKADIEEWKKNLNVIITVDKAEEGYTGNTGLVTKYVAELKLKDLENVEVVVVGPPMMMKFTVLEFLKLGVKEENIWISQERKMCCGVGKCGHCKIDDTYICLDGPVFNYTKGKLLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQF5</accession>
    <name>A0A174HQF5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA ligase</fullName>
            <ecNumber evidence="11">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">ERS852471_02208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266532.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75159">
        <property type="protein sequence ID" value="CUO75159"/>
        <property type="gene ID" value="ERS852471_02208"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="585"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="31"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO75159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="661" mass="74567" checksum="CD43A51E4E85CF69" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HR11</accession>
    <name>A0A174HR11_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266653.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77354">
        <property type="protein sequence ID" value="CUO77354"/>
        <property type="gene ID" value="ERS852471_02270"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO77354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="21695" checksum="0DCC40C47B4FA7BB" modified="2016-09-07" version="1">MECLRNKRNWKVLWQLFKSTFILSAFTFGGGFVIVSLMKKKFVEELGWLDESEMLDITAIAQSSPGPIPINASVILGYRMQGILGSIVAVVGTSIPPIAIISVISSFYVKFRESQIIGTALMVMRAGVAAVICDVVINLAKNVIKTGQVLYIALMIIAFIMTYVLGISAITVILLCILVGIVNLILDIKNSKKKANLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HR49</accession>
    <name>A0A174HR49_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">ERS852471_02232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266578.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76036">
        <property type="protein sequence ID" value="CUO76036"/>
        <property type="gene ID" value="ERS852471_02232"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO76036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="94" mass="10257" checksum="3B38DEE610DC2F99" modified="2016-09-07" version="1">MNIKPLGDRVVIKKLEAETTTKSGIVLSGTAKERPQEAEVMAVGPGAIHEGKRIEMEVKVGDKVLYSKYAGTEVKVDGEEYTILKQDDILAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRV8</accession>
    <name>A0A174HRV8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266559.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75639">
        <property type="protein sequence ID" value="CUO75639"/>
        <property type="gene ID" value="ERS852471_02223"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1750212at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="582" mass="65007" checksum="6D810C35AFDA8589" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HT57</accession>
    <name>A0A174HT57_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-tagatose-bisphosphate aldolase class II accessory protein AgaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kbaZ</name>
        <name evidence="2" type="ORF">ERS852471_02234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266582.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76099">
        <property type="protein sequence ID" value="CUO76099"/>
        <property type="gene ID" value="ERS852471_02234"/>
    </dbReference>
    <dbReference type="OrthoDB" id="395879at2"/>
    <dbReference type="UniPathway" id="UPA00934"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012062">
        <property type="entry name" value="GatZ/KbaZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08013">
        <property type="entry name" value="GatZ_KbaZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009264">
        <property type="entry name" value="TagBP_ald_AgaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="50783" checksum="8050BC32CA732FFD" modified="2016-09-07" version="1">MHPIKELVSKYKSGEKAGIFSVCSSNKYVIEAAMDRLRDKDMHLLIESTANQVDQFGGYTGMTPKDFMKYIHNLAEENNFPVDRIILGGDHLGPLTWTKLGEEKAMENSKTLIREYVLAGFTKIHIDTSMPIIGDFENGVFGDDLIAERAATLCKVAEDSYTELLNEKPESVHPVYVIGSEVPIPGGAQADEEEEEGIAVTKVENLVNTIETFKNAFESHGVGDAWQYVVGVVVQPGVEFGSEQVWKYDREKARELSEALKDYPELVFEAHSTDYQTDEALNEMVEDGFIILKVGPALTYGFREAAFELNLMENELLKYNANIELSKFREILEFNMVKNNGYWKNHYSGTQEKIKFDRIYGLSDRCRYYLPIEEVNYSLEKMIENLKQVDIPLTLVSQYMHNQYKKIRSGKMELTVENLLKDRIGEYIDDYIYAVENHKVLQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZI6</accession>
    <name>A0A174HZI6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative membrane CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ERS852471_02309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266709.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79066">
        <property type="protein sequence ID" value="CUO79066"/>
        <property type="gene ID" value="ERS852471_02309"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO79066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="46417" checksum="5076C4F154AD99C3" modified="2016-09-07" version="1">MDTSLIWQIGILIILLIMSGFFSMSETALMSLSKIRIRHMVEEGVKGAKLVEKLTEDPNRLLGAILIGNNVVNIGASALATTIATKIFGSAGAGIATGVMTILVLIFGEITPKSIAKQKSEKVALKVSKIINVIVKILKPFIGIFTAISSIFIRLFGGDPKASEPFITEEELRTMVGVSEEEGVLEDVEKEMIFNVFDFADAHVKDVMVQRVDVIAVDIDASYEEVLDIIKTEQFSRIPVYNQTIDDIVGILNVKDLIMAEKNSKPFKVSDYMREPYYTFEFKKIKELFKEMKKTRNHISVVLDEYGGTVGIVTIEDLIEEVFGDIEDEYDDYEKEIEVIKEDEFVVDGSARLDDISELIGVNMESEEFDSVGGLVIGELGRFPEQNEEVQLNNIRFVVEEVDKNRIKKVRIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I273</accession>
    <name>A0A174I273_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">dnaA</name>
        <name evidence="14" type="ORF">ERS852471_02374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266814.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81284">
        <property type="protein sequence ID" value="CUO81284"/>
        <property type="gene ID" value="ERS852471_02374"/>
    </dbReference>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="148"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="360"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO81284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="453" mass="51605" checksum="4660C96736800E07" modified="2016-09-07" version="1">METELKGLWEKTLNIIKSEMSEVSFNTWIKSCEPISISSNTIKISVPNSFTQDILEKRYKDLVINSIEAACSKLYKIEFLIASEIQDIEEVPEKKKASNNKDTMSVTVNDEMSSTLNPKYTFASFVIGNSNRFAHAASLAVAESPAQAYNPLFIYGGVGLGKTHLMHAIGHYILQNNPNAKVVYVSSEKFTNELINAIKDDKNEEFRNKYRNVDVLLIDDIQFIAGKERTQEEFFHTFNTLHEANKQIILSSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRMAILKKKADVEKLDVPNEVMVYIATKIKSNIRELEGALIRIVAYSSLTNRDITVDLASEALKDIISNKQNKNITIDIIQDVVAAYFNLRVEDLKSQRRTRNVAYPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISESLNNDESLQHTINDITKKLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBH9</accession>
    <name>A0A174IBH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine beta-lyase PatB</fullName>
            <ecNumber evidence="3">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">patB1</name>
        <name evidence="3" type="ORF">ERS852471_02398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266858.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82738">
        <property type="protein sequence ID" value="CUO82738"/>
        <property type="gene ID" value="ERS852471_02398"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO82738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="390" mass="44332" checksum="610101F0D8D8BC47" modified="2016-09-07" version="1">MEYNFSKLTNRFNTNSLKWDVKENELPMWVADMDFETAPEIIEAISNKVKLGIFGYTAIPEEYYLSISNWWEKRHNFKIEKEWILFCTGVVPAISSIVRKITSVGDNVVVQAPVYNIFYNSIVNNDRKILSSDLCYDGSNYYIDFDDLERKLSDNKTTLMILCNPHNPIGKVWDRETLERIGNLALKHNVTVLSDEIHCDLTYGNKEYIPFASVSKEIAQNSITCIAPTKTFNIAGLQTASIVIPNEELRKKVNRGINTDEVAEPNAFAMEATIAAFTKGEPWLNGLIEYLSENKSVVLEFINEKLPELKVVKSDATYLLWIDCSKVTEDSAELCKYIRSNTGLYVSNGAVYGGNGKTFMRMNIACPRIRLEDGLSRLEAGIKSYIENKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ID31</accession>
    <name>A0A174ID31_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spo0E like sporulation regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82975">
        <property type="protein sequence ID" value="CUO82975"/>
        <property type="gene ID" value="ERS852471_02404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018540">
        <property type="entry name" value="Spo0E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037208">
        <property type="entry name" value="Spo0E-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09388">
        <property type="entry name" value="SpoOE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140500">
        <property type="entry name" value="SSF140500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO82975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6331" checksum="D2DFA12F7B5A554F" modified="2016-09-07" version="1">MKILRVLIRAMKELLHETIERNGLLSLETISLSQRLDKLIYIKQKSIAESYINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFV9</accession>
    <name>A0A174IFV9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_3</name>
        <name evidence="2" type="ORF">ERS852471_02474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266998.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86124">
        <property type="protein sequence ID" value="CUO86124"/>
        <property type="gene ID" value="ERS852471_02474"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO86124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="240" mass="27683" checksum="69E8E0A4FA84ABE4" modified="2016-09-07" version="1">MIDKNSPIPVYFQLKNDLVKKIAQGLWKPGECIASERELCEIYGVSRMTIRQAIGELVQEGVLTRLKGKGTFVCEQTVKQQDMMSFTEMIKQTGRELRTEVINFDIIDTPDDMQDTFMLDKVYKIERRRIVDNECIAVETVFIPVDYCGHINNEMLKGSLYKILEHFGYSISNSTSSIVAVDITDEIKEKFDTKENFPVLKIIGKTFVNKNKVLFIEEALYRSDKFTLQVNISRREGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGD9</accession>
    <name>A0A174IGD9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266922.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84145">
        <property type="protein sequence ID" value="CUO84145"/>
        <property type="gene ID" value="ERS852471_02435"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1998386at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="7095" checksum="A23480891806CA1F" modified="2016-09-07" version="1">MYKYRYEKSSGGTFFTEPDHREVIDKLAREGWRFVAAIPTYQTGEGKVKEFDLVFEKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGS2</accession>
    <name>A0A174IGS2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="9">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">proS</name>
        <name evidence="11" type="ORF">ERS852471_02482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267017.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86432">
        <property type="protein sequence ID" value="CUO86432"/>
        <property type="gene ID" value="ERS852471_02482"/>
    </dbReference>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="38"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="569" mass="63224" checksum="4152C333DF7A4BF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IMM2</accession>
    <name>A0A174IMM2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GlcN6P deaminase</fullName>
            <shortName evidence="2">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nagB</name>
        <name evidence="4" type="ORF">ERS852471_02475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267001.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86175">
        <property type="protein sequence ID" value="CUO86175"/>
        <property type="gene ID" value="ERS852471_02475"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="3">
        <location>
            <begin position="11"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO86175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="242" mass="26470" checksum="797DD0AB16A3267D" modified="2016-09-07" version="1">MKLIVTKNYEELSKVAADEFAKVIIEKPEAVLGLATGGSPVGMYKELIAKCKNNELDFSKCTSINLDEYIGLNPEHEQSYRNFMNTNLFNHINIDKAKTFVPNGLAENLEEECKNYDKKIEELGGIDVQLLGIGNNGHIAFNEPGEELSAGTHIISLTESTIEANARFFDSIDEVPRKALTMGLGGIMKAKKIILIASGEGKAEAIKGLFSGKITTDNPATMLQMHRDVVVIIDEAAAKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IN63</accession>
    <name>A0A174IN63_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ispD</name>
        <name evidence="8" type="ORF">ERS852471_02480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267013.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86395">
        <property type="protein sequence ID" value="CUO86395"/>
        <property type="gene ID" value="ERS852471_02480"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO86395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="222" mass="25003" checksum="C47C89483EB4211C" modified="2016-09-07" version="1">MTSVIILAGGKGKRMGSKVSKQFIEIKGKPILYYTLKKFIDNKNIDQIVLVLPKDEIEYCKKEVLEKYSLKVDKIVEGGAERQDSVYNALKSMNDTDIVLIHDGARPIISDNLIDEGIRCAKKYGAAAPGVMPKDTIKVKNKENFSIDTPDRSTLVAIQTPQVFNYDNILKCHEKVKENGDVVTDDTMVSEKYGYKVYLYDGEYTNIKITTPDDIILAERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IUP3</accession>
    <name>A0A174IUP3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyamine-transporting ATPase</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
            <ecNumber evidence="8">3.6.3.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">drrA_3</name>
        <name evidence="8" type="ORF">ERS852471_02584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EC" id="3.6.3.31" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267178.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91172">
        <property type="protein sequence ID" value="CUO91172"/>
        <property type="gene ID" value="ERS852471_02584"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="PTHR19229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO91172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="27344" checksum="635D17523DF20501" modified="2016-09-07" version="1">MKAIEIKNLQKKFKNKIVVNSINLNIEEGELFALLGVNGAGKTTTIKMLSGLSKPTSGDALIFNKSILEDIDKIKEIIGVSPQETSIAPNLTVKENLEFMAEIYGFKKDNFKERTTEIINKFSLEEIENQKAKTLSGGWQRRLSIAMALISEPKILFLDEPTLGLDVLARRELWGIINNLKGKTTIILTTHYLEEAEALSDRIAIMVKGEIKALGTAIELKELTNTTSLEEAFVKIAEGEMKYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IV68</accession>
    <name>A0A174IV68_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267098.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88855">
        <property type="protein sequence ID" value="CUO88855"/>
        <property type="gene ID" value="ERS852471_02541"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992089at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="45791" checksum="47722EA7C7914F8E" modified="2016-09-07" version="1">MDNWNNKQKAIVQMVCLLLSIALWFYVTNVENPIKTQDINKVPVQLMNEGVLKDSNLTLAPNQQFFVNLKIEGTTQDLRKINKDDFEIVIDLSEYAYKIGANKIPVHIVDSPARVAIKNNSSLTLTIYIEEYVKKDIEITSDINIIAKPTYYVAPIEFSNDKVTISGPKSAIDNVASVVARGEEYNLSETISKSYHLYPVDENGNKVDNVTLSQDTIDATINVNEGKIVPVKVNTVGELISGIRLKDFTSNYKEVELSGPKEILDTIDVIETNPVNLSNITGDTTIDVDLKIPDKVQVNLGDVNSVSVTITVENESSKEVTVDVALNGVVDGLNLDVTNKTVRVKVIGYEEDIKNITAESITANLDLSSYTEAGQFTEYPAITLNSPNDKVRLEVLDKVSFNLEKVVTETTPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IX27</accession>
    <name>A0A174IX27_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pullulanase</fullName>
            <ecNumber evidence="3">3.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pulA</name>
        <name evidence="3" type="ORF">ERS852471_02608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91973">
        <property type="protein sequence ID" value="CUO91973"/>
        <property type="gene ID" value="ERS852471_02608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011840">
        <property type="entry name" value="PulA_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024561">
        <property type="entry name" value="Pullul_strch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11852">
        <property type="entry name" value="DUF3372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02104">
        <property type="entry name" value="pulA_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="151"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO91973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="660" mass="76419" checksum="75BB8B5A061C9AF2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IZL1</accession>
    <name>A0A174IZL1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
            <ecNumber evidence="4">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nox_2</name>
        <name evidence="4" type="ORF">ERS852471_02577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267166.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90778">
        <property type="protein sequence ID" value="CUO90778"/>
        <property type="gene ID" value="ERS852471_02577"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="333"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO90778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="443" mass="49091" checksum="68DAF9DBF4F25955" modified="2016-09-07" version="1">MKIVVVGCTHAGTAAVVNLKALHPESEITIYEKNDNISFLSCGIALNVGGVIKETKDLFYNSPENLAKQGVITNMKHEVLDIDFDNKKVKVKNLVTNEEFEDNYDKLVLTLGSWPIVPRFEGGDLENILLCKNHDHALTIIEKAEDAKNVVIIGAGYIGVELVEAFEMKGKNVTLIDAEDRIMPKYLDKEFTDLAEAEFKAKGVNFALGQKVQKFEGENGKVTRVVTEKGSYEGDLVVLCIGFAPNTKLVQGKLETLPNGAIIIDEYMRTSREDVFAAGDCCVVKYNPANDTRYIPLATNAVRMGTLVARNINEPTLKYMGTQGTSGIKIYDQCISSTGLTEGVAKATTNYNVASVILEDNYRPEFMPTYEKALIKLVYDKDTRRVLGGQIASKIDLTQFMNTLSVVIQNNMTIEELAMTDFFFQPHFNKPWSLLNSVALKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J2H6</accession>
    <name>A0A174J2H6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267293.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93873">
        <property type="protein sequence ID" value="CUO93873"/>
        <property type="gene ID" value="ERS852471_02650"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2037279at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO93873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="70" mass="8372" checksum="5BA12B2DD995F883" modified="2016-09-07" version="1">MSKCPFWSSKKEKVNCYNECPMYPVSKDDEVCPFIEHLNHNKVSINDFDDFEYSQNNIYDLSYMGIKNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDW4</accession>
    <name>A0A174JDW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
            <ecNumber evidence="2">3.1.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dgt</name>
        <name evidence="2" type="ORF">ERS852471_02737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.5.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267458.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97914">
        <property type="protein sequence ID" value="CUO97914"/>
        <property type="gene ID" value="ERS852471_02737"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="75"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO97914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="342" mass="39239" checksum="D51D2311F549B219" modified="2016-09-07" version="1">MNVREKIEKFENLTLAKQAILSTESLGREVFEEKDPIRTCFMVDRDRIIHSKSFRRLKHKTQVYIKTFGDHYRTRLTHTLEVAQIGRTIGVGIGLNENLIEAIALGHDLGHVAFAHNGEEVLDEFLEGGFRHNEQSVRVVKKLERDGRGLNLTHEVIDGILNHSGLSEGVNKAKTLEGRIVQYSDKIAYLNHDIDDSIRAKLLNEGDLPKDVIKVLGKTHSERIEVLVSDMIKETIKNLENNIYEVGQSNEVKEAMVELRRFMFANIYLGDVLKGERDKAKFILHQLLEYYCKHEEKLPELYRKIASEEGLKRAVADYIAGMSDDYCIGIFNELFVPKFVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JIE1</accession>
    <name>A0A174JIE1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267510.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99494">
        <property type="protein sequence ID" value="CUO99494"/>
        <property type="gene ID" value="ERS852471_02770"/>
    </dbReference>
    <dbReference type="OrthoDB" id="883596at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO99494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="458" mass="48899" checksum="9DCCC8DE61109018" modified="2016-09-07" version="1">MEKILSTINNIVWGVPLLVLLVGTGIYFTFKLGFIQISKLKLAFRYVFSKDENEIEGLEGDVSSFAALCTALSSTIGTGNIVGVATAIVAGGPGAIFWMWIAAFFGMATKYAEGVLAVKYREVDSNGQMAGGPMYYIEKGLGSKFLAKAFAVFGVGVALLGIGTFGQVKSIADAAKLSFNVPIIVTAIILTTIVSLVTLGGIKRISKVSEAIVPFMAIMYIVGVLMVLAVNIKLIPETIMLIIESAFNPRAAFGGVAGITILMVMQRGIGRGVFSNEAGLGSAPIAAAAAKTKEPVRQGLISMTGTFIDTIVICTLTGLAIVITKSYNIGLDGAAVTTSAFSSALPIFNIGKYIVNIGLIFFAFTTIIGWNYYGERCIQYLYGVNAIRPYKVVFIILVAIGPFLPLDIIFIIADICNGLMALPNLVGLIGLRKIVINETRDFFNLENNKDKVEVDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQ07</accession>
    <name>A0A174JQ07_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhhT_3</name>
        <name evidence="7" type="ORF">ERS852471_02787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00246">
        <property type="protein sequence ID" value="CUP00246"/>
        <property type="gene ID" value="ERS852471_02787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP00246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="41544" checksum="7FBBAE277F9FFCBC" modified="2016-09-07" version="1">MFLKNNKYKDAVVAALWIVVFSILAFKLFGYLDDITSTLGKIISLSMSFIYGIVIAYVLNPIVKIIESKTKMRRSLAIAVTYILFITIIAIISIYGIPSLIDSIRDMINKVPGYIDSAQRFLNDIVSNDNINGLINSTGTLGTIQSYIEKIGYVLMNLLEGSFNTLFNLSSQLVKVVLGFLVSIYVLSDKDKLINDWKRVLVLVLKEKRAKQVIEFGRIYNNMIGTYIGIKAIDSTIIGIMAFILLTIVKSEYALLLSIIVGITNMIPYFGPFIGEIVGFFINIFVSPTKGLVVFLTLFALQMFDGWYLDPKLIGSKVGVRPFWIIYAVVIGGGFFGPIGMLLASPTAATMKFYYSKLLEKNKEVIKNIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9B1</accession>
    <name>A0A174K9B1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BFD-like [2Fe-2S] binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267762.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05890">
        <property type="protein sequence ID" value="CUP05890"/>
        <property type="gene ID" value="ERS852471_02906"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019791at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="21859" checksum="6DC5BFEBE3DC4C37" modified="2016-09-07" version="1">MKKHKSEKIHQVVHDNDRKLNLHEIKAETGAGNGFKSSGEQSKVPIQDTYEASSKSEKIQEAMSNSEGKINLHTIKAQTGAGNGYNNTERASEISPIKDTFVNTNKFHKIHHVVSNIEGKANLHKIKAQTGAGNGYITQEDLKDNINTPSCDSKNPEPIYGTTHKSNHIHAVIHANDRKLNLHQIKQKTGAGSGYKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGN6</accession>
    <name>A0A174KGN6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267976.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11082">
        <property type="protein sequence ID" value="CUP11082"/>
        <property type="gene ID" value="ERS852471_03016"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1538718at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009323">
        <property type="entry name" value="DUF979"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06166">
        <property type="entry name" value="DUF979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="32277" checksum="160810665BBB9161" modified="2016-09-07" version="1">MDFAAFSNMLLELFYIIIGIMMLNTAVVTLKDKNHKAKYGTALFWSLLGIIFIFGHKLPYNVVGGMLVVIGILTLAKQVNPGTIKALDAKFGEEQANKLGLKVFIPSLVIAVSALLIAQFTPISGTASIGVAAVLAIIVTFFITKASPKVLVEESDRMIQSVGSTSILPQLLAALGALFTAAGVGDVISSGISSVLPQGNLLIGVAAYCIGMAVFTMIMGNAFAAFSVITLGIGIPFVFSQGANVAVAGALALTAGYCGTLLTPMGANFNIMPAALLEIEDKNAIIKNQAPVALALLFAHIVLMYFLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KM88</accession>
    <name>A0A174KM88_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267988.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11267">
        <property type="protein sequence ID" value="CUP11267"/>
        <property type="gene ID" value="ERS852471_03022"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP11267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="210" mass="24331" checksum="F6F09E97FE042FD6" modified="2016-09-07" version="1">MRIDSIIFDLDGTLWDATYSILDVWNNVLKNNYQEINKVITIEEIQSIMGLTSEEIVERLLPNIDKKLGLKIFDECAAAECDYLRVNGGNLYDNVEEVLIELNKKYKLFIVSNCQNGYVEAFLEAHNLEKYFIDFENYERTGLPKGENIKLVIERNNLKNPIYVGDTEGDYNATKLCNIPFVYARYGFGNVEDSQLIIDRFEELKSLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KNA4</accession>
    <name>A0A174KNA4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268069.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13443">
        <property type="protein sequence ID" value="CUP13443"/>
        <property type="gene ID" value="ERS852471_03064"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728906at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022595">
        <property type="entry name" value="Enc34_ssDNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10991">
        <property type="entry name" value="DUF2815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="20573" checksum="651626AD479D131D" modified="2016-09-07" version="1">MKNKKWVNKVITGEVRFSYVNIFEPRSINGENEKYSLSLIIPKSDEKTILEIEEAIFESEENGRKRFGLIESKKLRTPLRDGDVEKPGNPVYKNSFFINAKSTIKPQIVDINIDEIKDKAEVYSGCYGRVSLSFYPYQFNNNAGVACSLGNVQKLSDGERLDLSTTAKDDFKAYDVDGFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZR8</accession>
    <name>A0A174KZR8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">relA_2</name>
        <name evidence="8" type="ORF">ERS852471_03117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268164.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16191">
        <property type="protein sequence ID" value="CUP16191"/>
        <property type="gene ID" value="ERS852471_03117"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="654"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="728" mass="83306" checksum="261D5FA563E08908" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHY5</accession>
    <name>A0A174LHY5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 15" type="primary">rpoB</name>
        <name evidence="15" type="ORF">ERS852471_03228</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268354.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22326">
        <property type="protein sequence ID" value="CUP22326"/>
        <property type="gene ID" value="ERS852471_03228"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="26"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="140"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="364"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="489"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="567"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="696"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP22326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1237" mass="138872" checksum="565088B6A9F6B7CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEW0</accession>
    <name>A0A173XEW0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">clpS</name>
        <name evidence="3" type="ORF">ERS852471_00007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262676.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49165">
        <property type="protein sequence ID" value="CUN49165"/>
        <property type="gene ID" value="ERS852471_00007"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN49165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="99" mass="11472" checksum="94952B4F5F103934" modified="2016-09-07" version="1">MEPKIVTREKSKVKVKKPKHYKVIMHNDDFTTMEFVVYILTDVFRKDMLEAEKIMMDVHTKGRGVVGIYPYDIAVTKASLSMAKAKEEGFPFKVTVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLA1</accession>
    <name>A0A173XLA1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51405">
        <property type="protein sequence ID" value="CUN51405"/>
        <property type="gene ID" value="ERS852471_00047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="24502" checksum="CC6156CFB032F3DF" modified="2016-09-07" version="1">MMKEKEMQIDNLEKFDDIMHKYGRISTVVLIIMLLSTPFLIAMYFGANIDFKSALAGSIGICALFLPASIVEVITYAPMLGTGATYLAFITGNLTNLKIPCCMNARNLVGTEFGTKENEIVSTISVAISSITTIIVIAIGVMLMVPLEPIINSPVLEPAFSTVVPALFGALGYQYIKQAPKVAIIPFLLVSVLCFAVPNLASQVVVLIAVAAILSIVIARILYNKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMD2</accession>
    <name>A0A173XMD2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262748.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52106">
        <property type="protein sequence ID" value="CUN52106"/>
        <property type="gene ID" value="ERS852471_00055"/>
    </dbReference>
    <dbReference type="OrthoDB" id="136700at186801"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="148" mass="16737" checksum="B2346B6B70B84D08" modified="2016-09-07" version="1">MDNVLNIEKCKICGGLVSIENSSNGTTKICNCCGYFYNKENPKHELGCHCDKCHEEESESIEVKEIEYLNPCGAYKLVTSSGIGQVGTLGENVREEDVLKKFNFSDTSRLDLNKSYINYRNTETNEFKIIFGNGKPESYDEFVGRVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XR47</accession>
    <name>A0A173XR47_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54214">
        <property type="protein sequence ID" value="CUN54214"/>
        <property type="gene ID" value="ERS852471_00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="53" mass="5909" checksum="7B90092E461636F6" modified="2016-09-07" version="1">MSIENIILGIDYNLLVDLYLISVLALSIYAHKKGDRKTSLILNGIGFLSIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XX07</accession>
    <name>A0A173XX07_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase domain-containing protein</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nrnA_1</name>
        <name evidence="3" type="ORF">ERS852471_00150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56582">
        <property type="protein sequence ID" value="CUN56582"/>
        <property type="gene ID" value="ERS852471_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="184"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN56582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="318" mass="36478" checksum="64A9F87A8C89540D" modified="2016-09-07" version="1">MIYAPMKEIIEKIEEFDKIVLFRHVFPDPDSYGAQNALKNIIECTYPDKKVLLFGEHSKNLEYIGKMDESEELDKDTLAIILDVANAPRVDNQEFNNCGYILKIDHHKPFDAPFENLTWVDTNYTSTCEMILDLYLSNKDKLKIEKQGRKALFTGIIGDTGRFLYVENPTDIFKKLSEITFDLETKEIYANMYRREEEELKFLGYIYSNYKKTENGVAYLKVPKEDVANFGLETMKAVRMVNALQDTAGIINWMFFVEKPDGGVFCEFRSNGPRVNDIAAKFGGGGHMLAAGASIANFDIADKMIKEFDDNCKEYLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y030</accession>
    <name>A0A173Y030_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262960.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57551">
        <property type="protein sequence ID" value="CUN57551"/>
        <property type="gene ID" value="ERS852471_00170"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1520143at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="241" mass="26002" checksum="3C6F098BECA0B1ED" modified="2016-09-07" version="1">MNPYKVLGIRPNASKDEIEVAYKNIIESNNLNANSDNPVEFLTEEKLSKVNEAFHTLTNDIKLKEIRDLIESEQFLAAETELNLITDKKNAEWNYLKGFVLLKKGWFSAGVNHLKTAVELNPDNDEYQETMRLLTRKISQIRANYARVTAQNNSQNDMDLCGGGAGQGMGNGGDMCGGNQANAANILNNMAGGANPLAGGGNPLAGGGNMQNGNPLQSMLMQNLMSPNNMNMCGNGGGGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7S4</accession>
    <name>A0A173Y7S4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263035.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59723">
        <property type="protein sequence ID" value="CUN59723"/>
        <property type="gene ID" value="ERS852471_00211"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2146541at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="26347" checksum="C099CE4195705C7A" modified="2016-09-07" version="1">MIKRKILFVIYIFSLLINYDFYVNAYYEPGEEIIENNKPEYRSIDDLLKELKEERKLINQQKLDEINQKKLQEQNENGESQDEIHTQEPTKPKKDTDNENIPKLIVRLRGKHSPKYLCSYDFIISDDNKEIELTKEIINNYNLLIKKPSLKVRPGEIINFEFVPNCKSLKAHIWDEENETLKEVKVKRGCIEVPDLDKKIVIVITGNFSNGYIKYGIVLDIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8P4</accession>
    <name>A0A173Y8P4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">truA_1</name>
        <name evidence="4" type="synonym">truA</name>
        <name evidence="9" type="ORF">ERS852471_00226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263064.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60541">
        <property type="protein sequence ID" value="CUN60541"/>
        <property type="gene ID" value="ERS852471_00226"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="147"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN60541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="28406" checksum="E6781D4482626D98" modified="2016-09-07" version="1">MRNIRMIIQYDGSRYKGWQKQNIKGSSVSTIQDKIEKVLSKMTGDDIQVIGCGRTDTGVHADNYVANFKTNSTASISEFKSYLKMYLPEDIVIKDMMNCSERFHSRLNTISKTYKYTIDNNDFCNVFMKKYSYHIEEKLDVNKMIEASEVLIGTHDFRSFTSLKAKNGKSTIRTINYININEKDNIITITINGNGFLLNMVRIIVGTLIEVGKGNLSIENMRSILEEKDRSKAGEKAPAKGLCMLKVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YE33</accession>
    <name>A0A173YE33_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family 5 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">oppA_1</name>
        <name evidence="4" type="ORF">ERS852471_00234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263077.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61048">
        <property type="protein sequence ID" value="CUN61048"/>
        <property type="gene ID" value="ERS852471_00234"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016111" evidence="2">
        <location>
            <begin position="27"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="115"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN61048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="618" mass="69105" checksum="7A237BA252F720FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM48</accession>
    <name>A0A173YM48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yrrB_2</name>
        <name evidence="3" type="ORF">ERS852471_00256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64135">
        <property type="protein sequence ID" value="CUN64135"/>
        <property type="gene ID" value="ERS852471_00256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN64135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="36057" checksum="D7D197EC6B2983BE" modified="2016-09-07" version="1">MDKSYLFNNYISIARGFLAEKNNMKALKFLKKAYECEEGKEDVELILDIALLYDKLGNPVLSKKMYKEVLNIDENEARAYYGIGVLYDESENFIEAIKYYKKTISIDENYDKAYFFLANCYDEIGEKEKAIDCYKKVINLNPEDLWANANLACIYDEIGENKLALKYMMNALEIAPNHFRILFNMGVFMAKCGDEEKAKEFYKKSILENSKFPYSYLNYAVLYREKNKFKEAIDIISEGIKENPKQGFLYYNRACFYVNLKEYDKAFEDLHMSIKLDEIFEEYMRNDEELNPIRTLNKYIQLYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSR9</accession>
    <name>A0A173YSR9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoR_1</name>
        <name evidence="11" type="ORF">ERS852471_00291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263203.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65868">
        <property type="protein sequence ID" value="CUN65868"/>
        <property type="gene ID" value="ERS852471_00291"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031967">
        <property type="entry name" value="PhoR_single_Cache-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16736">
        <property type="entry name" value="sCache_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="231"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="351"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN65868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="561" mass="64026" checksum="B891927A2A6DCAC0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5V9</accession>
    <name>A0A173Z5V9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ackA_2</name>
        <name evidence="6" type="synonym">ackA</name>
        <name evidence="8" type="ORF">ERS852471_00396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263389.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71772">
        <property type="protein sequence ID" value="CUN71772"/>
        <property type="gene ID" value="ERS852471_00396"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN71772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="400" mass="44037" checksum="59DB44293270D9BD" modified="2016-09-07" version="1">MKTLVINCGSSSLKYQLIDMSTEESMVQGLVERIGIEGSQLTQKVEGREKYIIKAEIKDHKDAIKLVLEALIDEKHGVIKSMDEIAAVGHRVVHGGEKYSESVVLTEEVLKSVEECNALAPLHNPPNIIGIRACMELMPNVPMVGVFDTAFHQTMPKEAYICPLPYELYEKYGIRKYGFHGTSHKYVSNKVAEVMNKDIKDLKIVTCHLGNGCSLAAIKGGKSIDTSMGFTPLAGVMMGTRSGSIDPSVIGFLIKEKGYTMQEVDDLLNKKSGVLGISGISSDFRDVRDAAEQGNERAKLALDVFHYKVRAQIASYAGVMGGIDVIVFTAGIGENASLTRRESLKGLEFLGFELDNERNETRGEIQEISTDDSRVKVYVIPTNEELMIARDTVKLVENIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAN5</accession>
    <name>A0A173ZAN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263425.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72719">
        <property type="protein sequence ID" value="CUN72719"/>
        <property type="gene ID" value="ERS852471_00417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN72719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="70" mass="7798" checksum="87F9ED9C1A5F4AE1" modified="2016-09-07" version="1">MDNKEKVLIGAVSFLAGAAVGFLLAPVKKIVSFEKFSCNNIEDFEVDSSLETSEDNKVDKDEEKEEIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZC29</accession>
    <name>A0A173ZC29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263444.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73239">
        <property type="protein sequence ID" value="CUN73239"/>
        <property type="gene ID" value="ERS852471_00427"/>
    </dbReference>
    <dbReference type="OrthoDB" id="594914at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="28261" checksum="DB654B823684548D" modified="2016-09-07" version="1">MEADSIEIPINYLISPEYTVINYFSVLREAANPVKDKYTGCGTLGRAKEPYPIAYNFLTKEYKSNISYNKYEDSFKNILHINLIKLKEIPIDENIKDLKYFYEIETIQGTEFGAGAFVYYYGYIDLERIDGIYKISNITIIPEEYLCAPYHRWDYDGKLSVLIRYGDWCNLLKEIDKITIDGYVKNIYFKGNDGNEYRIEFYILTNDYDIEIAQFRKNEVGEWERIKINPEDCIKKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCP5</accession>
    <name>A0A173ZCP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263450.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73430">
        <property type="protein sequence ID" value="CUN73430"/>
        <property type="gene ID" value="ERS852471_00431"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="24254" checksum="71213CA78F365698" modified="2016-09-07" version="1">MDNLEFIYKRKSIRKFKEGEIPKEDILKLLDAATQAPSPKNQQTWHFVVLQNRDIINKMAEIVTNKHIYLAEIAKEEKQRKLMMNTLPYYICFKDAPVVVIVYSKEYKMIEEDILKANNANEEVIEILKSTHSEVQGIGAAVENFLLAATAMGYGACYMTGPAHSKREIEELINFNKEGYELMAMISLGIPEEETPKAPPRKPLDEVVTFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCS3</accession>
    <name>A0A173ZCS3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BFD (2Fe-2S)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263452.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73479">
        <property type="protein sequence ID" value="CUN73479"/>
        <property type="gene ID" value="ERS852471_00432"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1969696at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="59" mass="6306" checksum="7FCD6DE432DD390C" modified="2016-09-07" version="1">MSDKIICLCKGISEDTIIDAIKNGADTIEKVKEATGATTGHCHGSRCKGPIEELIAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZUF4</accession>
    <name>A0A173ZUF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ykoD</name>
        <name evidence="9" type="ORF">ERS852471_00489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN78828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78828">
        <property type="protein sequence ID" value="CUN78828"/>
        <property type="gene ID" value="ERS852471_00489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022216">
        <property type="entry name" value="ABC_Co_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12558">
        <property type="entry name" value="DUF3744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN78828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="600" mass="67203" checksum="0FFFA60F6C247162" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYC9</accession>
    <name>A0A173ZYC9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SWI/SNF family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263618.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80580">
        <property type="protein sequence ID" value="CUN80580"/>
        <property type="gene ID" value="ERS852471_00513"/>
    </dbReference>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="625"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="905"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1071" mass="124079" checksum="8BF1113988CFFB19" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ADP0</accession>
    <name>A0A174ADP0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00592</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86524">
        <property type="protein sequence ID" value="CUN86524"/>
        <property type="gene ID" value="ERS852471_00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
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            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="28815" checksum="0070EBE0DE37E5EA" modified="2016-09-07" version="1">MVNKSFKIAKMNINDMVKPIIIFYLIIIAVVTFTTIQNITNFNDNFHIVNSGLELATVIFLFVCGLNSFKENFYFAQSNNISRKSFIIGVIESIFPIAVVMAVIDVMINRITNIFVQMPTIYDILYTSTGADRVGIYNEWIQGNSFLTIINTFLLLLALYCFAYVLGVVINMIYFRCNTIMKVVVSIIPIALLNIAGVIELNNRYFFPSVYEGIRKVFGIATNNVYLAFLSLILIVMVLTGISFLLIKKAEVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AE78</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85786">
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        <property type="gene ID" value="ERS852471_00583"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN85786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="19091" checksum="FEDBB200D0EA3585" modified="2016-09-07" version="1">MKKSKDNKNSNKSTSSTDAFELYLKDLELALANLEKIGALFASFGYLTFFSAANLDTLDILNINNTGRTPEETFVYGQILISIGYTLLWIVSMNRYSEALLKLNNTEENPDLATLQQLKDSYLISLFANFYRLDAFIKLYKDSLEEDSSSNSTTESNTQETESNNFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174APN0</accession>
    <name>A0A174APN0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaI</name>
        <name evidence="2" type="ORF">ERS852471_00653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90407">
        <property type="protein sequence ID" value="CUN90407"/>
        <property type="gene ID" value="ERS852471_00653"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="13940" checksum="D93BEEC9B48278C3" modified="2016-09-07" version="1">MKEYKLAEGEMKFTEIIWDSEPIKSGDLVALCEEKFNWKKSTTYTVLKKLCLRGILENNNSIVTSLVSKDEYFKYKSEEFVEDTFGGSLPKFLAAFMGNKKLSKKQADELKELIDKYEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVT4</accession>
    <name>A0A174AVT4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensor with HAMP domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ypdA_1</name>
        <name evidence="6" type="ORF">ERS852471_00677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN92039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263910.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92039">
        <property type="protein sequence ID" value="CUN92039"/>
        <property type="gene ID" value="ERS852471_00677"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN92039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="583" mass="66710" checksum="6A286DF13F4E660C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B236</accession>
    <name>A0A174B236_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dockerin type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94279">
        <property type="protein sequence ID" value="CUN94279"/>
        <property type="gene ID" value="ERS852471_00688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018089" evidence="2">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN94279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="35670" checksum="928DDF8086428C60" modified="2016-09-07" version="1">MKRKFIAMLTVTALCLTIVSCSQSATSNNTETSNTITSTVATTDTSDEMGPVDATITLGNSISVDGTGATVSNNKVTITAGGTYSINGSLSDGQIIVDSPDLNNVYLVLNNVDLTCTNSAPIYVKAAENAIIVLPEGTTNTITDGENYVLQDATSDEPNSAIFSKDDLTIKGEGSLTVNANYNDGITSKDDLKITGGNITVNSADDGIRGKDSITIKGGNIIVNAQGDGLKSTNTEDTTKGYISIESGTLNITAGCDGIQAESNVTVLDGNITISSGGGSANASTKTNNDRMNPWGQWGATTSSSDTDSSSSAKGIKAVTNITIDGGNITIDSSDDSIHSNDSITING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B834</accession>
    <name>A0A174B834_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mobA</name>
        <name evidence="6" type="ORF">ERS852471_00720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264004.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96359">
        <property type="protein sequence ID" value="CUN96359"/>
        <property type="gene ID" value="ERS852471_00720"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019898at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN96359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="191" mass="21932" checksum="08825DC090FFEB66" modified="2016-09-07" version="1">MINKTLAILAGGKSSRMNYNNKAFLSFKEKTFIEHIINAGKNFKEVIIVANDKEVYERFNLRVVEDIYKGNGPLSGIHSALKSSTTDCVLCVACDMPLVSSELLDFLGNYNENYDVLVPKYKDRLQPLCSIYSKNILGKIEESLIKNENKLQRFIMSSNYKVIEKLGNRKFEEEDFLNVNTPIEFNELEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BB76</accession>
    <name>A0A174BB76_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98282">
        <property type="protein sequence ID" value="CUN98282"/>
        <property type="gene ID" value="ERS852471_00756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="24885" checksum="D1B319495DC774A3" modified="2016-09-07" version="1">MDFIYIKAAEEALALDLKKDKALIINLAYMVILALTLVYDMMAKEGVHTFRIALAAVTAWIMFFVYKKTFLRRSRISFYLIFTFVFAAMYLGSVLDFYIIIPGYDKILHLISGVIIAYIGYIFYLTLVKTDDKEAVNPMMGVVFSIIFSIAAAGVWEIWEFSTDQLFGFTSQNNSLIDTMMDIICGTVMGILANIPIAMYIKGKKVKFIEKLVEDMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BH01</accession>
    <name>A0A174BH01_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264133.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99944">
        <property type="protein sequence ID" value="CUN99944"/>
        <property type="gene ID" value="ERS852471_00788"/>
    </dbReference>
    <dbReference type="OrthoDB" id="886332at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN99944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="38794" checksum="545ED1CA3463CA4D" modified="2016-09-07" version="1">MGLFKNQLLNVIEWNETRDDVIFWMWKNNEIKKNSRLIIRPGQDAIFMQNGKVEGVFTEEGNYEVETEIIPFLSTLKGFKFGFNSGLRAEVLFINTKEFLVRWGTKGPINIPAPGMPGGMPIRCFGFYTVKVDDYMTLIDKVAGIKSQFTVDDIKIRTSAIMDGLLMKWIVKEGKNMFNLQVNSAEIAKGLKVDLDMQLLQIGLTVTGVTIENFNYPEQVQKMIDKNAAYGMVGNIGHYQNVAMVESMEKNPGSSMGNMAQAGIGIQMGMEMAKEMKSNIENSKSNVSNSSICPNCHSNIDSNAKFCPNCGEKVVKAEEQNSKKKFCPECGAKQDGNSKFCSECGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJH3</accession>
    <name>A0A174BJH3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lrp</name>
        <name evidence="2" type="ORF">ERS852471_00796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264150.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00349">
        <property type="protein sequence ID" value="CUO00349"/>
        <property type="gene ID" value="ERS852471_00796"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="160" mass="18226" checksum="82FFAB35E401D6AB" modified="2016-09-07" version="1">MEEILEILEQNSRYTDEEIAVMAGKTVEEVREAIRDYEEKSIIAGYTTLINWENTGKETVTALIEVKITPQRGVGFDKVAERIYKFPQVKACYLMSSGGFDLTVIIEGKTMKEVAMFVSDKLAVQEFVNGTATHFVLKKYKDHGTIFKEKKVDTREAIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BN62</accession>
    <name>A0A174BN62_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01038">
        <property type="protein sequence ID" value="CUO01038"/>
        <property type="gene ID" value="ERS852471_00807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="110" mass="12018" checksum="AF0238943F2B75AB" modified="2016-09-07" version="1">MELLVTILEENENIEDIMLEFNKLGIKGSTIIDSQGMANILSECEEFSLFSSLKLLMNDGRAQKKTILTVLKSNMVDSAISAIKKFVDIDSPGSGIIFTVPVGRVEGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BR10</accession>
    <name>A0A174BR10_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">malP</name>
        <name evidence="11" type="ORF">ERS852471_00855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264260.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03482">
        <property type="protein sequence ID" value="CUO03482"/>
        <property type="gene ID" value="ERS852471_00855"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO03482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="753" mass="86682" checksum="BB2E3D4EDC6029F3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C376</accession>
    <name>A0A174C376_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264328.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06335">
        <property type="protein sequence ID" value="CUO06335"/>
        <property type="gene ID" value="ERS852471_00882"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1892309at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="12709" checksum="C8CD82FDB12AA790" modified="2016-09-07" version="1">MENDIKRINLTQFLQWNDRNGCYTDENCDLEDLPRMTYEDAVKYFFCVINDDFYYSITDNIFDLSYEEIINYAKENRFYEITYEKLNLLINNDNPTIEFYKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CB96</accession>
    <name>A0A174CB96_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264491.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10752">
        <property type="protein sequence ID" value="CUO10752"/>
        <property type="gene ID" value="ERS852471_00968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="16501" checksum="6417C9BEC6B4B075" modified="2016-09-07" version="1">MYISMPRDFFVPVMYDYKENLGLLDKRTTEMNRESTGEEKVNQEYYKALQNKEATYIKPGSKETNGQEVDEEYYKALQEKEATYVEATMYNSIDDEYINSATNNKDKYINKGETKENYKGSNSRSVYSDIDDEYARGFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CG22</accession>
    <name>A0A174CG22_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0229 protein ERS852471_00971</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhbH</name>
        <name evidence="3" type="ORF">ERS852471_00971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0229 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264550.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10920">
        <property type="protein sequence ID" value="CUO10920"/>
        <property type="gene ID" value="ERS852471_00971"/>
    </dbReference>
    <dbReference type="OrthoDB" id="481720at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01232">
        <property type="entry name" value="UPF0229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014230">
        <property type="entry name" value="Spore_YhbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006698">
        <property type="entry name" value="UPF0229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30510">
        <property type="entry name" value="PTHR30510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04285">
        <property type="entry name" value="DUF444"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02877">
        <property type="entry name" value="spore_yhbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="394" mass="45346" checksum="710157B747383B9A" modified="2016-09-07" version="1">MAIFRDNSDNPIEHDRSIEDRRRHRQLVEKSIKENIGDILSEESIVGETKNKKFKIPIRGIKEYQFIFGKNSTGVASGTGEEKRGDKVGSADGSGKKGNKGAGQGEGDDIYETEITMEELLDYIVEDLDLPNLDRKKFSEVLTESASRKRGYQKYGIRPRLAKKKTVMSKTARKQGKKRALMESGIDQELERFPFREDDLRYYKVKKKPKKESNAVLIFIMDVSGSMDTTKKYLARSFFFVLSRFIKRKYNNIAFEFISHTTVAKNVNEYEFFHKAESGGTYISSGLNLALKIIEEKYSPEVWNIYPIYASDGDNWSEDNERAINAVKNLCEISNMFGYAELLPSTYSTTMYYRFNKEIHEKNFVSVIIKEKKNLWDALKIMLSKELKEGNDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGX6</accession>
    <name>A0A174CGX6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">recQ1</name>
        <name evidence="14" type="ORF">ERS852471_00973</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264499.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11018">
        <property type="protein sequence ID" value="CUO11018"/>
        <property type="gene ID" value="ERS852471_00973"/>
    </dbReference>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="185"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="215"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="11">
        <location>
            <begin position="512"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="588" mass="68067" checksum="B5888AE6A7E0027D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CMU8</accession>
    <name>A0A174CMU8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO14851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264558.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14851">
        <property type="protein sequence ID" value="CUO14851"/>
        <property type="gene ID" value="ERS852471_01021"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1700311at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO14851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="175" mass="19699" checksum="EA56B32F35F6A332" modified="2016-09-07" version="1">MSKVRKMLGKADSPYIISLMRLIETQSKNTIVKWCNKYAREHILPIYEKDYPEDYRLKNALNAVDEWLERNIKLAEAKKIIKEVQIAAREVEGNPAAQAAARAIGATTTTINTITSSLGLAFYGSAAIAYSSIGTSENIEVYDEIAARECKKMEEDLRKISIKDEPNPAKINWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNH1</accession>
    <name>A0A174CNH1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF_2</name>
        <name evidence="3" type="ORF">ERS852471_01015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264546.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13295">
        <property type="protein sequence ID" value="CUO13295"/>
        <property type="gene ID" value="ERS852471_01015"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="92"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="37223" checksum="8E269FA3E1DFF206" modified="2016-09-07" version="1">MVVILKPKTSTEEINKLTKDLESKGVTVNPVIGTELIILGLVGDTSKIDPCYIEANPYVERVMHVQEPFKKANRMFHPEDSIIDVNGNTIGGRKISIIAGPCSVETEEQILTVAEDVKKYGASFLRGGAFKPRTSPYSFQGLKYDGLELLKIARKQTGLPIVTEIMSPYDIDIFAENVDVIQVGARNMQNFDLLKELGKINKPILLKRGLSATIEELLMSAEYIMAGGNENVILCERGIRTFETYTRNTLDLSAIPAIKKLSHLPVIVDPSHAAGKWWMVEPLAKAAVAVGADGLIIEVHNDPQKAWCDGQQSIKPELFRNIMNDLRVIAEAVGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVM4</accession>
    <name>A0A174CVM4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15676">
        <property type="protein sequence ID" value="CUO15676"/>
        <property type="gene ID" value="ERS852471_01037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="46" mass="5146" checksum="647DA7334B8947FC" modified="2016-09-07" version="1">MDKVICPKCNEIVTEGAGVKSEGIITCEKCKYQLHWECDGEKTISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXM7</accession>
    <name>A0A174CXM7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein cotJC</fullName>
            <ecNumber evidence="2">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydbD_1</name>
        <name evidence="2" type="ORF">ERS852471_01084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264609.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18004">
        <property type="protein sequence ID" value="CUO18004"/>
        <property type="gene ID" value="ERS852471_01084"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1420351at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="22933" checksum="58592E3DCBA1569C" modified="2016-09-07" version="1">MWYYVKTLEYPINLQSKDLKMAKYLMSQYGGPDGELSAALRYLNQRYTMPTNKSKALLTDIGTEEMAHVEMIATMIYQLMSNATLAELEDAGLGGHYVDHGRALYYADAQGNPWTATYIQAKDDVVADLHEDMAAEQKARATYEWLINLTDEEEIKEILRFLRQREIVHFQRFGEALMNVQDHITQNGSKVYYPKNDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYS9</accession>
    <name>A0A174CYS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sarZ</name>
        <name evidence="2" type="ORF">ERS852471_01091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18424">
        <property type="protein sequence ID" value="CUO18424"/>
        <property type="gene ID" value="ERS852471_01091"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16686" checksum="B1ADD72CF695878E" modified="2016-09-07" version="1">MERKNKAFRAAMMIKELYSKTTNIISDNLRESGLTHQQCMVIQLIAHKKEMTITELCKEMSLAKGTVSGIVQRLEKLGYLEKEKREDDKRNTYIKFSKNGLDFANTFKSNMSSSFENIFSNCSEEDMDEMIVDLRKILNKIEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7B6</accession>
    <name>A0A174D7B6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Class V aminotransferase</fullName>
            <ecNumber evidence="7">2.-.-.-</ecNumber>
            <ecNumber evidence="7">2.6.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pucG</name>
        <name evidence="7" type="ORF">ERS852471_01120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="7"/>
    <dbReference type="EC" id="2.6.1.45" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264639.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19908">
        <property type="protein sequence ID" value="CUO19908"/>
        <property type="gene ID" value="ERS852471_01120"/>
    </dbReference>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050281">
        <property type="term" value="F:serine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="29"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO19908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="377" mass="42797" checksum="BDFA33CAC3210EFF" modified="2016-09-07" version="1">MDKLIMTPGPTFIRENVREAMGKPITNPDLDIEFYDFYKNTCEKLQNIMHTKNQVLILDGEGILGLEAACASLIEEGDKVLCIENGIFGYGFKDFAEMYGGTVTFFSGERDRGIDIGKLEEFLKENHDFKVATVVHCETPSGITNPIKDICPLLKKYNILSIVDSVSSIGGEEIQVDEWNIDIALGGSQKCLSAPPGLTFLSISEDAIEAMNSRETPIRSFYANLTIWNDWYENKWFPYTQPISDIYAFDKALDNFLGDKDVLQRHKRYAEACRYAVKECGLELLSKDCHSNTVSTVLVPEGINYKDLFNKLYSEHNIIIAGGFDFLQDKIFRIGHMGENCYEEKLYITLKAINTVLKELEFNLKGDLHKEFVNYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9H7</accession>
    <name>A0A174D9H7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_01174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264688.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22432">
        <property type="protein sequence ID" value="CUO22432"/>
        <property type="gene ID" value="ERS852471_01174"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1313516at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO22432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="407" mass="45921" checksum="F9231F478BA435A2" modified="2016-09-07" version="1">MLLTLIKNELIKLLKKGKTWIVFALFALFIGITIFGQYSSDKNMRMWQSPEKQLEMAKENLDYYKEELELNKNSDVNPEYIASLEESIEYSKEQIKSYEDIIKNGVNEDEWKKQLDEEIEYAKESIIRYEKYDDEWSKQYAMESKERLEQLTYLRDNNIQPLYGWEYDAYNYMSSLMQFLGMAILVAGIAVFMSDIVSGECTPATLKFLLIQPVTRGKVLLSKFIAVTITVLTMILGAEILGFLFVNITSGVNNSAYPVSIGTVYEKIINADGTTILSKVVGSGHMGTNLELFTKAMLFQALFIITACAVIFMISTLIKSSMITMAISVVVTVFLTIGSYNLSALRKIAHLVFLNFGDSISVFTGSSAMMMQNPNMTVTNGVIVMIATTLVAYLIAHINFSKKDILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTQ5</accession>
    <name>A0A174DTQ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein ERS852471_01282</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264845.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28834">
        <property type="protein sequence ID" value="CUO28834"/>
        <property type="gene ID" value="ERS852471_01282"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="26881" checksum="7A70752382E8FD26" modified="2016-09-07" version="1">MSGHSKWHNIQNKKGKADAQRGKIFTKLGKELVLAVKNGGPVPENNPKLRDAIAKAKAANMPNDTINRSIKKASGELASVDYERIVYEGYGPLGVAVIVETLTDNRNRSAGDVRAAFSKGGGTLGTTGCVNFMFQEKGEIVIERADLDEEEVMMMALDAGAEDFEAEDEVFVVTTSPDDFGTVREALEAEGLEFLEAAVKMIPDTYTEIDEEAAKKMQKILNMLEDSDDVQEVYHNAEFPEGWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DU17</accession>
    <name>A0A174DU17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein co-occurring with transport systems (COG1739)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yigZ</name>
        <name evidence="4" type="ORF">ERS852471_01280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264841.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28727">
        <property type="protein sequence ID" value="CUO28727"/>
        <property type="gene ID" value="ERS852471_01280"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1777855at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO28727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="215" mass="23934" checksum="03BCA3B9934B832C" modified="2016-09-07" version="1">MAYITIRQYGEDEFIEKKSQFIGYAKRCESEEEAKAFVAEIKSMHKQATHNCWAYVVGKNMGIQRYSDDGEPQGTAGIPILEVMKKSNVTDCAIVVTRYFGGIMLGAGGLTRAYTKGASIALKAGGVVEKVEGVNVSLEMDYDMIGKVQYMCGQNNWHIEDTEYTDKVIVHILAEISVADEIEKAAIEASNGKILISKSDAEIYFKEDNRLYKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4T3</accession>
    <name>A0A174E4T3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_01345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264955.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31466">
        <property type="protein sequence ID" value="CUO31466"/>
        <property type="gene ID" value="ERS852471_01345"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO31466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="447" mass="49923" checksum="2E715058CCDF31D8" modified="2016-09-07" version="1">MKLNMNKEELRKFLLHAPQDRIMKYIEGIHPVDILDILREDEEDRKDILNRLSEKCIASIIDEAEDEEKYEILTEFSENKQKNIIEEMSSDELTDLLGILSQEQANKILSKMTAEDARRTRQLLSYEPDTAAGIMATEFVSVKGEMTVEDTLKYLQGTTEDVENIYDLYVIDELDRLKGVVSLKEVVTSSFETKISDIIHVKVEGIPYDLDQEEVGHRFEKYGYLTMPVVDNYNRLLGIVTVDDVMQILRDESTEDIHRLGGVDEGERISGTLSESIKSRLPWLIVNLFTAILASAVVGMFEGTISRIVALATFMPIVTGMGGNAGTQTLTIIVRGLALGELDFDNMKRVFFKEIGIGLVTGVVIGAIIAVLGYLWEGKLFFGLIIGVAMILNMIVATISGFVVPVVLKKLKVDPALASSIFVTTFTDVLGFLFFLGLATIFVEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMC4</accession>
    <name>A0A174EMC4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265186.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38397">
        <property type="protein sequence ID" value="CUO38397"/>
        <property type="gene ID" value="ERS852471_01477"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO38397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="28803" checksum="6F102456510E8884" modified="2016-09-07" version="1">MDNNYVLITGASSGIGYELAKLFERDGYNLILVARDKEKLQMAVDKLNNEKNKIIMLDVDLSREDEVDKLIKYINKNEIDINILVNNAGIGSFGEFAEIDWKTEEKLIDINIKALTKLTKYFLPKMIEKKSGGILNVASTAAFASGPRMATYYASKAYVLNLTEAIHEEVKEYGINISCLCPGPVRTSFQSKAGIKKSEKAKKYLMNADIVAKVGYDKFKKGEVIIIPGFKNRVLVNANKLLPRAISRKIILKTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXB8</accession>
    <name>A0A174EXB8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265290.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42111">
        <property type="protein sequence ID" value="CUO42111"/>
        <property type="gene ID" value="ERS852471_01530"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909525at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6524" checksum="44A15380D61B0561" modified="2016-09-07" version="1">MEDKKIICKDCGKEFVFTVGEQEFYKEKGFENDPVRCPECRKARKAQRPNRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F158</accession>
    <name>A0A174F158_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">algA_1</name>
        <name evidence="2" type="ORF">ERS852471_01542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265314.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42648">
        <property type="protein sequence ID" value="CUO42648"/>
        <property type="gene ID" value="ERS852471_01542"/>
    </dbReference>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="40119" checksum="92E5D4770CE9017B" modified="2016-09-07" version="1">MLCALIMAGGKGTRFWPLSTEEKPKQFLNLVGERTMIQMTVDRIIPIIPIERIFVCTGDKYTDYIKEQLPNLPDRNIIIEPEGRNTAPCIAVSSIIIERYYNDSSILVLPADHLIEKEEEFREIILKANKFIENNHESIVTLGIKPTRAETGYGYIKFQNDDKSEILKVDKFVEKPNKQLATEYLKEGVYLWNSGMFLWKSKHIIEEIKKYIPNTYEALSALSYIEKSKIREYINNNYRKTDNISIDYAVLEKAKNIYVIPSDICWDDIGTWEAVERYKEKDVDNNIISNNVRIIESKSNMIVNNQKKIILIGIEDIMALETEDEIFIVNKKYMDNLRDFQNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F304</accession>
    <name>A0A174F304_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wbbL_2</name>
        <name evidence="2" type="ORF">ERS852471_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265310.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42555">
        <property type="protein sequence ID" value="CUO42555"/>
        <property type="gene ID" value="ERS852471_01540"/>
    </dbReference>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="31421" checksum="B3DCE88F2006DC3C" modified="2016-09-07" version="1">MKNNDYISIIIVNYINYSLTIKCIESILEKNILNKYEIIVIDNNSPNLSYEELTFKYKNVNKVKVIKNERNSGFGNANNLGVKESNGNIILILNPDIIVLDNAIDEMINMLKSNERIGIVSGKLLNEDGSLQYSCRRVLSFSKFLQSRTPLSKFIDNNKKELITSEYLMKDMNHDNITEVEWVMGACMMIYKDLFLDLGGFSKEYFMYFEDVDLCCKVRAVKKKVIYLPNAKMIHLHRQESTKKINKMTLIHLLSMIKFYFKYYTGKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4A2</accession>
    <name>A0A174F4A2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">ERS852471_01574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265378.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44387">
        <property type="protein sequence ID" value="CUO44387"/>
        <property type="gene ID" value="ERS852471_01574"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO44387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="37166" checksum="3003553F7FA212A4" modified="2016-09-07" version="1">MAVLVSGGMGYIGSHTTVELLNAGFDVVIADDLSNSKELVKDRIEKITGKTTKFYKVDLTNEEEAEKVFLENNIDSVIHFAAFKAVGESVEKPLEYYYNNITSALVMLRLMRKHNCKNFVFSSSATVYGDAKVVPITEDSPLSATNPYGRTKLMIEDMLRDIAKADPTLNVAILRYFNPVGAHKSGTIGEDPNGIPNNLMPYITKVAVGELKQLRVFGNDYPTHDGTGVRDYIHVVDLAQGHVKALEKLKTNPGLVTYNLGTGNGYSVLDVVKAFAEASGREIPYEIVDRRPGDIATCYADPKLANEELGWTAERGIKEMCEDSWRWQSNNPKGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F689</accession>
    <name>A0A174F689_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265358.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43860">
        <property type="protein sequence ID" value="CUO43860"/>
        <property type="gene ID" value="ERS852471_01563"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1411221at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="27715" checksum="8FC86E6108B3453B" modified="2016-09-07" version="1">MKYREIREKYQGQNETIVDAYATSISPIITKWFLTKKFTPNEITIMMILSGIIGAILFSINSIILKMLGIVFIHMWYILDCSDGEVARIKKQFSKFGTEIDYSAHILNHPLFNISFAISLISLNRYNIAFVLVLTIILISIDGIFRNLYAFEVIYKVKMEEEIQKGAIYKGSRLSILKRVVFQFVHYPNYALIFPIIFVSDYFIGSNIAILFLISIITVQVPMILKSYIIWIKRIKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9L1</accession>
    <name>A0A174F9L1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ExoQ family exopolysaccharide biosynthesis membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265457.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46257">
        <property type="protein sequence ID" value="CUO46257"/>
        <property type="gene ID" value="ERS852471_01616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="468" mass="53766" checksum="6FE63247A9CD932C" modified="2016-09-07" version="1">MKKASIYYISYSVFIFCFMILCNNKLSKAVVFSGIFLLLGLGSFYINKNYLKSLIFLLGFCLPINLSFYYLNYYPDRNIAGALVGWKFTLLDLIIFLIIIYSFRNFTSKIFRKKINILILVYLLINIFSVNVALDKYAALFEVVRLLKCILLMYAIITTFNSELYDVFVDAIGKTIIVQFILGILQIIKGGNLGLSFLGESQRVFRDGVTGLEKGMSGTLGHPGTMAIFTLFCLTMLIFNTRLKNRKLYILISIITIILTFARTSIILMCFIIIIYKITTRKKFTLTYKKLIIVYLIAAISLVGALILKDQIGDIVNRFIASDFSNQVDGRGEHSQLAIQIYNNRESWSYGANNYIFASQKNFPNHYSLQHFKYIFPVHNLYCLYLVELGVWGMIIYIALISIPIINWFIFDILKGKKTNKYLITFAVWSIVIMIYNFTGWSGAKDILVYPMWIVLGLSECFSNKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEM9</accession>
    <name>A0A174FEM9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">dacB2</name>
        <name evidence="18" type="ORF">ERS852471_01633</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265490.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47997">
        <property type="protein sequence ID" value="CUO47997"/>
        <property type="gene ID" value="ERS852471_01633"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1499212at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021601" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="16">
        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="17">
        <location>
            <begin position="281"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="427" mass="48425" checksum="FA374AAFA27BB5F2" modified="2016-09-07" version="1">MKKTLTKFLLLLFICTLFFTNITIENVHAVPLLEAQGVVLMDGKSGEILYSQNADVQYEPASITKVMTAIVVLENTNLDDKVTIGTNPPLVDGSAIGIREGEVYTIEELLIAMLLESANDCAEALAEFVSGSNAEFGKLMTERAKELGCTNSVFKNPSGLHEEGHLTTANDMAKIMRFALNFDDFNRISRIISYQYVNHPYSDGTEKWATNRNNCYVDWSQWYYENLYCGKTGWTPEANHTYVATAVKDDEVLVASFLNAYNKDTQYTSVGELFNWGFDNFNSVKLFNKGDIVGEYQISDNTSIPLLTNKDIYYTLSANEEQNITTAFNYADKDYSESSIKKGDVLFDATLIVNGEKYTTLELLSGLDREYTTKIKIENTINKYASNKIIISIILILILSLCIYIYIRKRKLNKRRDFIRKKYNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIY9</accession>
    <name>A0A174FIY9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrdB</name>
        <name evidence="7" type="ORF">ERS852471_01648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265519.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48786">
        <property type="protein sequence ID" value="CUO48786"/>
        <property type="gene ID" value="ERS852471_01648"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="379" mass="41642" checksum="1063B157A15BB30B" modified="2016-09-07" version="1">MIIPLSQFKMDKKKFKEIDKWMLFSIVTIVLFGILNIYLATKPYAYNTTYVIKQSLFFGVSLVALYLIMALDYSIIKGFTPLFYWASIVLLVLVLIIGKAVNGAQGWINLGIVSFQPAELAKVATIMMMGKKLEDMDGNINNFKNFCILAVYAIIPAALIVIQPDMGMTMVLFFMVVGVFFAGGLDKRIIIGGLTGLVVAIVLVWNSGLIQPYQKMRIISFQNPEANSSEEGYHLRQSLIGIGSGGFLGTHNSLSKDSAGGYASQYVPEVETDFIFAQIGEQWGLLGAAFLLALYGILICRMIAIARDSKDMFGNIVAIGMTSYLLFAIWQNIGMTIGLMPITGITLPLVSYGGSSLLTTILSLGLVLNIGMRKKKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FM16</accession>
    <name>A0A174FM16_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH</fullName>
            <ecNumber evidence="2">1.17.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ispH2</name>
        <name evidence="2" type="ORF">ERS852471_01661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265544.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49510">
        <property type="protein sequence ID" value="CUO49510"/>
        <property type="gene ID" value="ERS852471_01661"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="197"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="282"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="382" mass="43078" checksum="3CA279E171C34705" modified="2016-09-07" version="1">MSEELREDSMKDLLKEFDVKRIKSGDILKGQVIDVNDKEVAVNINYAFDGVISREELTNDDKSPLEVVQKGDNIDVYVISPNDGEGYVQLSRVRALQITEKEEIKKAFESGETIKVRVKEEVKGGVVAYYGSIRVFIPGSQLSRERVDFKNFIGKELEVKLIELDMRNRKVVASRRVIEEEQYQVEKKALWNNLKEGEKREGTVKKILKVGAIVDIGGITGLVHINDLSWERVKRVEDIVNVGDKVTVFVGNIDAENERVSLILKDVNQEPWKVYGDNIKVGEVIEGTVAKLVSFGAFVEIYSGIEGLVHINEITDENIAKASDVLTVGQKVKVKVLDVNKNDRKISLSIKDAIERSNEYLQYNDSDEEVTLGDLFKGLFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSP6</accession>
    <name>A0A174FSP6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">atpD</name>
        <name evidence="12" type="ORF">ERS852471_01711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265627.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51866">
        <property type="protein sequence ID" value="CUO51866"/>
        <property type="gene ID" value="ERS852471_01711"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="145"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO51866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="465" mass="50900" checksum="17EB9A5CF346E5DC" modified="2016-09-07" version="1">MGEQKVGKVVQVIGPVVDIKFDSDSLPNIYNKIEIEIGKEKLVTEVEQHIGDDIVRTIAMEATDRLKRGMKAVDTGNCITVPVGEEVLGRVFNVLGNTIDNEGPIESKERYPIHRSAPSFKDQSLEPEVLETGIKVIDLLTPYQRGGKIGLFGGAGVGKTVLIQELINNIATEHGGLSVFTGVGERSREGNDLYYEMKESGVINKTALVFGQMNESPGARMRVSLTGLTMAEYFRDKGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGALQERITSTKNGSITSVQAVYVPADDLTDPAPATTFTHLDATTVLSRAISELGIYPAVDPLESSSRLLDPRIIGDEHYTVATEVKNILERYKQLQDIIAILGVDELSDEDKKVVARARRVQRFLSQPFTVAEQFTGMKGKYVPISETVRGFKEILEGKCDNIPESLFLLSGTIDEVKEKASKMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1H3</accession>
    <name>A0A174G1H3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">steT_2</name>
        <name evidence="6" type="ORF">ERS852471_01783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265764.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56303">
        <property type="protein sequence ID" value="CUO56303"/>
        <property type="gene ID" value="ERS852471_01783"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO56303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="47970" checksum="3B072B3C4CF4164E" modified="2016-09-07" version="1">MKKNEYGLFTAIAMIVGVVIGSGIFFKSDNILVATGGSISLGVLVFGLAAIAIIFGSLTISELASRTSQAGGVIAYAEESYNKSVACAFGWFQTFLYFPTLIAVVSWVAGIYICMLFGFESTLNVQIFIGLAITIVLFITNTLSAKLGGYFQNASTIIKLIPLIFIAIIGLIFGDVSKVSFSDVTTMQSAGWITAIAPIAFSFDGWIVATSIGHEIKDSKRNLPKALIIAPIFILLVYIIYFVGVSTYLGPDAVMSLGDGHVDLIANKILGPFGAKIILIFVIISIIGTVNGLILGLIRLPYSLAIREMFPNSKNISKLDQKINMPLNSAMVAFALCIFWTIVHYLTTKFGLLSNSDISEISITVSYVMYILLYVKVFKLGREGEVKGLWRGTINPILAIIGSLIILTGSLGNELFFVYALVCGMVILSSVAFWKKRAGELELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5L6</accession>
    <name>A0A174G5L6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dacB_2</name>
        <name evidence="11" type="ORF">ERS852471_01785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56428">
        <property type="protein sequence ID" value="CUO56428"/>
        <property type="gene ID" value="ERS852471_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022269" evidence="9">
        <location>
            <begin position="26"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="61"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO56428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="398" mass="44416" checksum="DDA705B75B304884" modified="2016-09-07" version="1">MNRKTIIKVICSILLIMQSYSICSASVLFEEDSEEMEDEIIITEDREINDVDNSLVLDKLRVNARNAIAIDGTTRQILYEQNCYEVVPMASTTKILTALVALNEGDLDRELTVTKNAASIRGSKVGYKAGETIKLRELLYGLMLKSGNDAAITIAEGLGGSIENFSKIMNHYATSLGLTTSHFETPHGLDSQKHYSSAYDLAILTAKAMENDTFKEICGEKLITQDKYNFTREYQNINKILWKIPDANGVKTGYTGGAGKCLVSSVKHEGRNIIIVVLNCSDRWNVTEKIFNYVCTNYDFKKESNSEIIKSNAISNLGSIVEEADFQYGSKEKANLEVEVFKPIMNVLKGDIIGKISLKDEGNEVLRQEIRCNKNISKDKYDTVLSMSHSDKEDTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5M6</accession>
    <name>A0A174G5M6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly A polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57281">
        <property type="protein sequence ID" value="CUO57281"/>
        <property type="gene ID" value="ERS852471_01802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="56"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO57281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25768" checksum="6CF29A60A3CA2532" modified="2016-09-07" version="1">MSTLLRYIIDHLLADAKPSIYLKSIKESLKDTPLEILIELESVEQEKKHHPEGNVWNHVLLVVDQAATIREYANSPKSLMLAALLHDVGKKAATKKNRSGRWISYDHDKIGADLARKILKNYDIKEDEIDKVCNMVRYHMHHLFIIKNLPYGNVEGLINDVDINDMALLFISDRLGRNQETYEEKSKEVLDVLEILDILKRNYNVDVTQAKENVEKILKNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEK1</accession>
    <name>A0A174GEK1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265958.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60974">
        <property type="protein sequence ID" value="CUO60974"/>
        <property type="gene ID" value="ERS852471_01888"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1409917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="233" mass="26452" checksum="F1181A8888B46D18" modified="2016-09-07" version="1">MVAFIDYRTTTTEKNSLSKLNINFIEVPKNPILYDAIDGHVDIQLNIIDKKEKKIIIQKDIDDTFIEKLKLYDITYIKSFSSLAEKYPGNIMLNAAILDDDIIHNFKYTDKNLISSLDNKKFINVKQGYSKCSILPVRNKAIITNDKGIYDTLKTEGYDILLLPPGDILLPGLNYGFIGGVGGKISDNSLAFFGNLNKYKYGKEIKHFLNKYDITPVYLHEGKLIDRGSLLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GF67</accession>
    <name>A0A174GF67_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265961.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61063">
        <property type="protein sequence ID" value="CUO61063"/>
        <property type="gene ID" value="ERS852471_01890"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="29049" checksum="57BF8CB750A0C837" modified="2016-09-07" version="1">MAYGEFAKIYDELINEDINYDEMVSRIIDICKEENINFNNYLDVACGTGNVTIRLATKFKDVFAVDLSEDMLREAFEKFKVNKIKGKVICQDMTELRLNKKFDLITSVLDSTNYIIDEEGIVSYFQSINEHLNDDGIFIFDINSYYKLSQILGNNIYTYSEEEVFYTWENTFEDSLLSMFLTFFVKNGDLYERFEEEHLERAYKEEDIEKYLKLANLEIINKFDGYTDCKVKADSERLVYVVKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQQ1</accession>
    <name>A0A174GQQ1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266092.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64793">
        <property type="protein sequence ID" value="CUO64793"/>
        <property type="gene ID" value="ERS852471_01962"/>
    </dbReference>
    <dbReference type="OrthoDB" id="797299at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="240" mass="28414" checksum="8389EBFA3BE21F02" modified="2016-09-07" version="1">MNKIPKIIHYCWFGRGEKPDIVRRCIDSWKKNLIGYQIKEWNEDSFDINTNDFVRQAYENKKYAFVSDYVRVFALYNYGGIYLDTDVEVIQNFDKYLDNESFWGFEVGNYVATSTIGATKGNKLIKKFLDSYEGKTFLNEDGSFNVTTNVKIVSKIFEDLGIKLNGEYQRIEGIGAIYPLEIFSPYDYRYYEDLRNNDTVCIHHYYKSWLPISEKIKQYLKKNIIKIFGSKILKKKERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GW45</accession>
    <name>A0A174GW45_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tagE_2</name>
        <name evidence="3" type="ORF">ERS852471_01974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266112.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65276">
        <property type="protein sequence ID" value="CUO65276"/>
        <property type="gene ID" value="ERS852471_01974"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="361" mass="42365" checksum="A594A32D1C8A661F" modified="2016-09-07" version="1">MKIAFFTINIDQIGGIESVITSLSNYFINKLNYQVDVISLFGKEKDIMNRKLTEKVNRIYLNMDYLEEKDRFSQLINSYKYGKQLKEYLGNIQYDFIIGTHFNTNMICILNKKDIKGKIIGSEHSEYYQAGRLTRLIRALYYRKLDKFIVLTNEQKELYGRYLKNVKVINNPISFKSNEISNCENKRIITAGRLSHEKGFDRIIDIFSVISKKYSDWVLDIFGEGQQKELLQKKIKDYNLEDKIRILPFTNDIKQEFLKSGIYVLPSRNEAFSLVLLEAMECGLPSVSFDTSGPKEIITNNVDGIIIKNDDLNKFIEELEQVIMDIDIRKKYGREAKKQVKRFYIENIAKEWNGLFEEVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYJ0</accession>
    <name>A0A174GYJ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase</fullName>
            <ecNumber evidence="1">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266214.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67714">
        <property type="protein sequence ID" value="CUO67714"/>
        <property type="gene ID" value="ERS852471_02021"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="266" mass="30208" checksum="4AB5843482C89E0D" modified="2016-09-07" version="1">MSKKIAFFDIDGTMVNVPNGLLHPTKETIRVLNEFKKQGNYIVVATARGAAPESIKDIDFNGYICNDGHYIVFNNEILVDDIFTCDEIQRQIDTYLKFDGRFMFGGHVDTWNSFLDDSLVIEHRQMFSGTSERPIGIIEEFKASDVEAVSCCVLFDSIEKLEACYDELKDSFTIVPYRTGLIRMDVYREGFTKGTACEYLYKKLEIEKENSYAFGDGINDKEMLELVGHGIAMGNGLEEIKKIAHDVTDTVDNDGIAKAFKRYFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZB8</accession>
    <name>A0A174GZB8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Four helix bundle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66358">
        <property type="protein sequence ID" value="CUO66358"/>
        <property type="gene ID" value="ERS852471_02002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="166" mass="19541" checksum="E8A93759CE754135" modified="2016-09-07" version="1">MDKFWECKRADILLTQKSEINKFYNCVYYIINMERVIYNRSICLGCGFMNSEILELSRSIATDSIYICRELIKLREYSIADQLKRSCTSVGANIGEAMYAESKRDFIHKLNISIKECSESIFWIRTIKDNSIIEDEIIIKRLYNNCFSIKRLLWATIKTTKKTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2X9</accession>
    <name>A0A174H2X9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266212.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67676">
        <property type="protein sequence ID" value="CUO67676"/>
        <property type="gene ID" value="ERS852471_02020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="12605" checksum="BADD5691B81EB75A" modified="2016-09-07" version="1">MGLLNLGLILGSGIAVIGGVDYLKRKLLIVFRRWDKLGLDKYRIKRYYKDGNAIVILVEVAIGGSVSDLKNYTGKIEKAYGCKCEIQDIEYSKYITVILNYEESLESIKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HA19</accession>
    <name>A0A174HA19_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase RhlE</fullName>
            <ecNumber evidence="12">3.6.1.-</ecNumber>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rhlE_2</name>
        <name evidence="12" type="ORF">ERS852471_02116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="12"/>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266381.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71754">
        <property type="protein sequence ID" value="CUO71754"/>
        <property type="gene ID" value="ERS852471_02116"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO71754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="435" mass="48654" checksum="9B7A6582A7C39F9D" modified="2016-09-07" version="1">MLFKDLNIIEPILRSIEEAGYEKPTAIQEKSIPAILKGRDILGCAQTGTGKTAAFAIPILQSIIEEKKTNNDRNLKALIVAPTRELAIQIGENVTTYSKYLDIKSTVIFGGVNQSSQVRKIKSGIDVLIATPGRLIDLSNQRHVDLKNVKYFVLDEADRMLDMGMIHDVKKIISRLPKERQNLLFSATMPKEVMKLVNSILKNPIKVEVQPASSTVDIISQGAYMVSKKNKKSLLVHLLKDESIKSVIVFSRTKHGANKIAKDLNHVGIEAAAIHGNKSQNQRQLALNNFKEGSLRVLVATDIAARGIDVDELSHVINYDLPDVPETYVHRIGRTGRAGRDGVAITLCDSEELEIFRRIEKVIGKSIPVLEEEKFEIINIVPPVIKQGTDKHKSNNSRKSRRYQGKGKEQKNRNEKMSNGSRDRKYSTNNKLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCK6</accession>
    <name>A0A174HCK6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_9</name>
        <name evidence="6" type="ORF">ERS852471_02137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266421.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72642">
        <property type="protein sequence ID" value="CUO72642"/>
        <property type="gene ID" value="ERS852471_02137"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO72642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="462" mass="49845" checksum="ECDB36B532C50598" modified="2016-09-07" version="1">MSNQKYLAEESIGKLLLKYSIPAIIGMLVNALYNIVDRMFIGRIPEVGSLALTGVGITMPIMSILLAFGMLIGIGSTANISLNLGRGKKDVAEKLIGSAVTLSLIVGIAITAIGLIFINPILNIFGASSNTLFYAKEYITVILVGSTFNILSFALNSTVRADGNPKMASFTMIVGCLTNVVLDYVFVFMFNMGIKGAAFATVISQALTFFIILYYYTKGKSNLKLKIPNLKLQKSLIMMTFAIGIAPFATQIANSLVQVVANNALKTYGNDLAIGAMTVISSLNMVFMMPIFGINQGCQPIIGFNYGARKFERAKKTFIYATIAATIICSIGGILIQLFPQLAISIFNNDAELTGLAVKGLRIYLLMMPIVGINIVATSYYQSVGKAKMSMFVSLLRQVILLIPFTLILPKFMGLDGVWAAGACADLLSVVITIILIAKEFKSLNKLTIEENSQATLDVVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGH7</accession>
    <name>A0A174HGH7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266397.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72230">
        <property type="protein sequence ID" value="CUO72230"/>
        <property type="gene ID" value="ERS852471_02125"/>
    </dbReference>
    <dbReference type="OrthoDB" id="556766at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotid_trans" evidence="1">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="36349" checksum="03D413EDCC078C73" modified="2016-09-07" version="1">MKKSVFCAVVSKTRLIQGIACFLSLYETLDDFVIYVLCVDNKCYEFLKKVNFDRLRLFTISQLNRADLIDLEDKRLLNQYCWTLKPGFIRYIFEMDNSIERVTYIDSDLFFLQDVRIIFENQPEASVLLSSGEIFLPMYSKEFNQYMQYLTGKYNSGFISFKNDINGIECVKWWDKKCIESCTANPEDNKFGDQKYLEDMPFLFKDVEEITTPGINIGHWNYPKYRFSVKDNNIMVNNDKLIFYHFSGFRIVNKNDIRQIHEEDRINQPFIYEIYRKLLTNLIDEVEKIDPTFIEYKTVAEVEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHY8</accession>
    <name>A0A174HHY8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_5</name>
        <name evidence="2" type="ORF">ERS852471_02147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266441.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73026">
        <property type="protein sequence ID" value="CUO73026"/>
        <property type="gene ID" value="ERS852471_02147"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="453" mass="49343" checksum="0B5A8492DA412107" modified="2016-09-07" version="1">MELTVFKRENDFYKRMLAIAIPITLQNLITIGISMADTMMLGSLGEVALSASALANQFSFIFLVIHFGLAGGAGVLTGQFWGKGDKESISKTLSMMLKISAIFSFTFFILGQFFPSQIMRIYTPDPSVIAEGVKYLKILSFAFLVQGFSTIAIGILRTVGIVKLALCSTAISFFANIFLNWMFIFGNLGAPRLGAAGAAVGTLISRIIEFLIVAIYLIFIDKRIQFKIKDLFKHDKAIFTDYAKHGTPVLISDFILVIGLNMLSVIMGRMGAEMVAANSINTVLQQFCTVFLMGVANASGVIIGNTVGAREYDKAQDYGKTFLVLAILIGCISGLLIFSLKNVMIGFYDVAGSTKEIAYQLMNTTSIIVVFSAVGSTLTKGVLRAGGDTKFLMKADVLFLWLLAIPLGFIAGVVLNLPAGIVFFCLKIDEVIKALWCTKRLLLDKWIKNVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMK2</accession>
    <name>A0A174HMK2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxoguanine DNA glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alkA</name>
        <name evidence="2" type="ORF">ERS852471_02237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.21" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266588.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76193">
        <property type="protein sequence ID" value="CUO76193"/>
        <property type="gene ID" value="ERS852471_02237"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1781735at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052822">
        <property type="term" value="F:DNA-3-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052821">
        <property type="term" value="F:DNA-7-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="125"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="303" mass="35238" checksum="BC4C2E3EE27D51FC" modified="2016-09-07" version="1">MDYKEVIQIDDNSIMIKGVKNFDIKQILECGQCFRWEKISDTNYIVVAYRRVIEIVQNGDDVTIYNTNLNDFEEIWKDYLDLNTNYSELKEELAKDEILRKSVEFGYGIRILNQEPFEMLISFIVSARNSIPAIMKTIKKISERWGDKIEYKGNTYYAFPTPEQIKDATLEEIKDTGASFRSKYILDTIGKVNEALENPDNEELKIYNLDYIKSLNTDECHVALQQFMGVGAKVADCIMLFSMAKKSAFPVDVWVKRAMIHFYVAPDVSLNKIRVFGRDKFGELSGLAQQYLFYYARENNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNQ0</accession>
    <name>A0A174HNQ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cadmium, zinc and cobalt-transporting ATPase CadA</fullName>
            <ecNumber evidence="9">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cadA</name>
        <name evidence="9" type="ORF">ERS852471_02248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266610.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76582">
        <property type="protein sequence ID" value="CUO76582"/>
        <property type="gene ID" value="ERS852471_02248"/>
    </dbReference>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="830" mass="90572" checksum="D9D12DF59605E764" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPW5</accession>
    <name>A0A174HPW5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266555.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75566">
        <property type="protein sequence ID" value="CUO75566"/>
        <property type="gene ID" value="ERS852471_02221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="148" mass="16763" checksum="6F607D36B551D8FA" modified="2016-09-07" version="1">MSSMMEFTAEKTPLTKNIDKKKGMTLVEIMAAMAILSILFVAISGLMINTVKIESRADKILETNNYLKSALLVFDEKMADVSEYIVEKTIEFSNVNEMQRRIVNKDYSSTGKYSMNIKSELQSDGLYKVIATMQNKNIEETKILIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRD2</accession>
    <name>A0A174HRD2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Apolipoprotein N-acyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lnt</name>
        <name evidence="10" type="ORF">ERS852471_02254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266622.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76781">
        <property type="protein sequence ID" value="CUO76781"/>
        <property type="gene ID" value="ERS852471_02254"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="236"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO76781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="357" mass="40761" checksum="8FF75AA51EC3E69E" modified="2016-09-07" version="1">MKTDLYKGKILIIILSAIISGISFTVDNLGILMWISFIPLINILIRQENTFIKIFKIGTIFGTTYYLVLLHWIFNLYPFEWLDLGKTKSIIILFCGWILISLLEGLVIGIVLGIFKYLKVKNNLLNIFTIASLWVVIEYIQEQGLLGFPWGKLAISQVDYLPIIQSISLFGSSFISFIIIVFNGMILEGLVNYKKNKAVAMKLVFIAILIFIVNIAYGYAKLNERVDSKEVNVTVVQGNINTTEKWQKGDIFKSFNIYKELTVEAVENSSTYGDKTEVVLWPETAIPIDISKNSWILQEYKALAKSLNVTFMTGTFYTDYKNDCYKYNSIVAINSDGDIEDIYFKRHLVPFGEVLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HV18</accession>
    <name>A0A174HV18_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aldH</name>
        <name evidence="9" type="ORF">ERS852471_02260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266635.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76988">
        <property type="protein sequence ID" value="CUO76988"/>
        <property type="gene ID" value="ERS852471_02260"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293754at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="458" mass="51988" checksum="1C37468C50ACFD62" modified="2016-09-07" version="1">MKEIKNIFSDQRKFFDSGKSNDIDVRIKQLKTLKKVIKENEKEILQALKDDLGKSNFEAYATEIGLVYDEINLHIKNVRKWSKREKRSSPIVYYPSKSYIYKEPYGVTLIIGPFNYPFQLVIAPLIGAISAGNTAIIKPSETTINTARLLEKIINENFDKGYIRVVNPLGGKEVVSYLLDLPFDYIFFTGSVRVGKIVMEKAAKNLTPITLELGGKSPCIVDRDANINLAAKRIVWGKFLNAGQTCVAPDYLFLHKDIKDKFLRTLVKEIKTQFGEIIKESPDYPRVVNTISLDRFSNYLNDGDIYFGGEIDKDQLYMDPTILTNVKLDSSVMTDEIFGPILPVIEFENLDETISIINHREKPLALYYFSESNKNIEYIIERTSAGGVTINDTIIHVANGNLPFGGVGPSGLGKYHGKDSFNTFTHSKSVMKRGTFIEFKVRFAPYNNRINLLRKIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HVC6</accession>
    <name>A0A174HVC6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">folA</name>
        <name evidence="6" type="ORF">ERS852471_02302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78932">
        <property type="protein sequence ID" value="CUO78932"/>
        <property type="gene ID" value="ERS852471_02302"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO78932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="162" mass="18759" checksum="6FE2291413FF16DD" modified="2016-09-07" version="1">MISLIVAIAQNNVIGGDNKLLWHISDDLKRFKKITSGNTIVMGRKTFESLPRVLPNRKHIILTRDKNYTVDNPSVEVIHNINDIINNFKNSPVEVFIIGGGEIYNQFINSVDKIYLTKVFKNFEGDTTFPEIDYNNWNITFESEIFTDEKSNINYQFINLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HYE1</accession>
    <name>A0A174HYE1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system, glucose subfamily, IIA component</fullName>
            <ecNumber evidence="4">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ptbA</name>
        <name evidence="4" type="ORF">ERS852471_02286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78357">
        <property type="protein sequence ID" value="CUO78357"/>
        <property type="gene ID" value="ERS852471_02286"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1481289at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO78357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="170" mass="17831" checksum="219F03F028C391D9" modified="2016-09-07" version="1">MANFFKNLFKSKSKVEEAPKNFLVAAATGNAIPLSEVPDQVFAQKLAGDGMAIMITGDTVVAPADGELSLVFKTKHAFAMTLENGLEILVHIGVDTVSLNGEGFEQLAEQGTKVKAGTPIIKIDREFILSKGLSLATPVLITNVDAAKSITPVESGSVVAGETAVVNFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2J4</accession>
    <name>A0A174I2J4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recF</name>
        <name evidence="10" type="ORF">ERS852471_02377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266818.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81404">
        <property type="protein sequence ID" value="CUO81404"/>
        <property type="gene ID" value="ERS852471_02377"/>
    </dbReference>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO81404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="361" mass="42006" checksum="4EEA9E4CCD4B30CF" modified="2016-09-07" version="1">MFIKKLQMLNYRNYEALNIDLGPNVNVFMGDNAQGKTNILEGIYYCAFAKSHRTSRDKELINWKSENAFLSVTVGRERLDKRIDISILKDGKKAIRINKIKINKIGELFGNFNVVMFSPEDLKIIKDSPGVRRKFIDMELCQLDSKYYYNLVQYNKVLNERNTVLKNRSINKDILDIYDMQLVEFGYNIVMKRINYINKLNQYSKQIHNDITSGKENIEFKYVSTIRNLENIKESFYSQLEKNRSKDIDKGLTSVGPHRDDFMVFINEIDTKSYGSQGQQRTAVLTIKFSSLKIIKELTGEYPVLLLDDVLSELDFSRKRYILSTIGEIQTIITCTGIEDLYEYLDDKSKVFKVKDGAILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2K5</accession>
    <name>A0A174I2K5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rlmH</name>
        <name evidence="2" type="ORF">ERS852471_02323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266733.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79588">
        <property type="protein sequence ID" value="CUO79588"/>
        <property type="gene ID" value="ERS852471_02323"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1783583at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00246">
        <property type="entry name" value="tRNA_RlmH_YbeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO79588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="159" mass="18406" checksum="894CEEB6EBBD21CA" modified="2016-09-07" version="1">MNITVISVGKLKEKYLKLAIDEYAKRLGRYCKLDIIELPDEKTPDNASEKEELIIKDKEGQLILSKIKDNMFVIAMDLNAKQMTSEEFSKFIETQGVMGNSNITFVIGGSLGLSQDVIKRANYKICFSKMTFPHQLFRVMLLEQIYRAFRIMKNEPYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ICL7</accession>
    <name>A0A174ICL7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266862.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82815">
        <property type="protein sequence ID" value="CUO82815"/>
        <property type="gene ID" value="ERS852471_02400"/>
    </dbReference>
    <dbReference type="OrthoDB" id="170130at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="52"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="228"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="352"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="696"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="776" mass="89436" checksum="0694F5025FF70445" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174INY6</accession>
    <name>A0A174INY6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">glmM_1</name>
        <name evidence="6" type="synonym">glmM</name>
        <name evidence="13" type="ORF">ERS852471_02546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO89062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267107.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89062">
        <property type="protein sequence ID" value="CUO89062"/>
        <property type="gene ID" value="ERS852471_02546"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="157"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="258"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="373"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO89062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="447" mass="48363" checksum="B6909C6EA8D8C6E1" modified="2016-09-07" version="1">MSRMFGTDGVRGVANTELTADIAYSLGRAGAYVLTEGTHKPKILVAKDTRISGDMLEAALVAGILSVGAEAVLLGVVPTPAVAYLTRKYNADAGVMISASHNPVQDNGIKFFDNRGYKLDDSIEDEIQRVIESNFAEVPSPIGGAIGRCSTEPRALDEYIDFVKSTITGDLKGVRVGLDCANGAAYEAAVKAFRELGAVVRVINDNPDGENINDACGSTHPEELMDYVVRKNCDLGFAFDGDADRCMAVDEKGNLIHGDYILTLCAKHLKDEGKLKDDTLVVTVMSNLGLDIACKKENIKTIKTKVGDRYVLEEMLKNGYVLGGEQSGHIIFLEHNTTGDGLLTALQVASIKKHTGKTLSELAGIMKELPQVLVNARVTNDKKNIYLEDEEIINSIKEIEAKLNGKGRVLIRASGTEPLIRVMLEGENQEEIDKMAHDLANLILSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVT8</accession>
    <name>A0A174IVT8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267105.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89009">
        <property type="protein sequence ID" value="CUO89009"/>
        <property type="gene ID" value="ERS852471_02545"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="31909" checksum="9087AE4B94720408" modified="2016-09-07" version="1">MRTTVNINNKLTMISEMINDSTFQILEYENLSGVSSIENTININRLQNYGITLKQARIILDNSSVKVQPGALSFMKGDVSIKSNIEVTSKFSQRLFKNKKIDESMIKPIIEGKGEVFLEQTLEYFTLVELEDDEVIIDDNIFYACEEEIEIYKIMKRTSQMKEDDEDIVQLKLKGSGIVLLKIPVPESEILRCKLYKDKLVVKDDLVVLRTGNVKLSVESSGNTIIRDISDNDDKVDIYTGIGEAWIIPTKNIYNKTFNISSDICKENFDDDDENDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IXW5</accession>
    <name>A0A174IXW5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">walR_3</name>
        <name evidence="11" type="ORF">ERS852471_02562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267139.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90198">
        <property type="protein sequence ID" value="CUO90198"/>
        <property type="gene ID" value="ERS852471_02562"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="WalR-like"/>
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        <property type="entry name" value="REC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
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            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO90198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="232" mass="26862" checksum="0C86380D5ECFF63A" modified="2016-09-07" version="1">MCKYTVLVVDDEKEIIDAIEIYLQNEDIRILKAYDGLEALEILEKEEVHLVIIDVMMPKMDGMRATMKIREDRNIPIIILSAKSQDTDKILGLNVGADDYITKPFNPLELIARVKSQLRRYMAFGHYKEEEDLEKIKVGDLELDKRSKSFQVNGENVKITPIEYKILELLMSNAGRVYSAEAIYESAWGEPCFSTDTVMVHIRRIREKIEIDSKNPRYLKVVWGIGYKIDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J011</accession>
    <name>A0A174J011_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YmaF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO93024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267255.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUO93024"/>
        <property type="gene ID" value="ERS852471_02625"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024307">
        <property type="entry name" value="YmaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12788">
        <property type="entry name" value="YmaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO93024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="15974" checksum="733BC07B8D69040A" modified="2016-09-07" version="1">MSNSCNEYYSEEYNENNNDNCNENYNDNCNENYNDKHVHEFTGSVKLAETGDDRHNHRTAGITSEPRYCENGRHYHLIKAQTDSAPDDHHHPIIIRTGLDIKIRGTNKHVHAIKGATRVVDQHCHNFEFATLTERPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J2M9</accession>
    <name>A0A174J2M9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267190.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
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        <property type="gene ID" value="ERS852471_02590"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="11"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO91329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="409" mass="44241" checksum="19FFF6FCD2B9AA03" modified="2016-09-07" version="1">MDIVKVIISLIGIGIIAYWSGRIVEFIKLPSLVGMIIVGMIIGPTFLNLVPEVTLNIAPQIKDIALVTVLFIGGLGISLNQMKSIGRPAILLSAIPALIEGLTIAFLSTKFLGFTFVQGGILGFIIAAVSPAVLVPSMVELINKKIGQDKAIPQMLLVGASADDTVAITLFTTFLAVYMSGSGGEKISVISEIVNIPMTIVFSIAIAWILAIITNPLFKKIKENILKIVMVMIICLTIRVIENITHFKLFNSLLIIMIYGFFLRTYLGDMAKGIQDGINIIWKYGKLYLFAFVGMAINPKLVGEYFFIGVFMLLISLTMRSLGVLISLIGTNLTLKERLFCVIAYLPKATVQSAKAGIPLKMGVESGDIMQAVAILSVLITAPIGAIGIKLTSKRFLTVEGEEENEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JAC7</accession>
    <name>A0A174JAC7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoVB2</name>
        <name evidence="8" type="ORF">ERS852471_02656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267305.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94155">
        <property type="protein sequence ID" value="CUO94155"/>
        <property type="gene ID" value="ERS852471_02656"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="359"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO94155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="535" mass="58794" checksum="72AB096A09F625DE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JB04</accession>
    <name>A0A174JB04_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 4</fullName>
            <shortName evidence="6">EF-4</shortName>
            <ecNumber evidence="6">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lepA</name>
        <name evidence="8" type="ORF">ERS852471_02710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267405.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96823">
        <property type="protein sequence ID" value="CUO96823"/>
        <property type="gene ID" value="ERS852471_02710"/>
    </dbReference>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO96823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="601" mass="67092" checksum="4DBBC3AFDD285DDE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JG92</accession>
    <name>A0A174JG92_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Germination protease</fullName>
            <ecNumber evidence="1">3.4.24.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GPR endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Germination proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spore protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gpr</name>
        <name evidence="2" type="ORF">ERS852471_02706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates the rapid degradation of small, acid-soluble proteins during spore germination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase action with P4 Glu or Asp, P1 preferably Glu &gt; Asp, P1' hydrophobic and P2' Ala.</text>
            <dbReference type="EC" id="3.4.24.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A25 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.78" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267397.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96658">
        <property type="protein sequence ID" value="CUO96658"/>
        <property type="gene ID" value="ERS852471_02706"/>
    </dbReference>
    <dbReference type="OrthoDB" id="799376at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00626">
        <property type="entry name" value="Germination_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005080">
        <property type="entry name" value="Peptidase_A25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03418">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019549">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01441">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5008186646" evidence="1">
        <location>
            <begin position="1"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023562364" description="Germination protease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="35362" checksum="250B81517B3853DD" modified="2016-09-07" version="1">MINIRTDLAIEAKQAYTEENKRELDGVKVDEEYEGEVKITTVTIESDEAGRELGKPKGHYITLDIPDFALYDGESMDEVSKVFGKTLKKLVDIDKDKLVLVVGLGNWNVTPDALGPKVVEKTMVTRHIKELMPDAIDDSVRPVCALAPGVLGITGVETGEIVKSLVDRIKPSLVICVDALGARKLERVNRTIQIGDTGISPGAGVGNHRMQINEESLGCKVIAVGVPTVVHAATIVNDTMDLLLDELISKAETGKEFYNMLHSVDRAEKNALIREVLTPFVGELMVTPKDVDLVVENLAKVVANGINIAIQPDMELEDINKFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JL00</accession>
    <name>A0A174JL00_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">feoA</name>
        <name evidence="3" type="ORF">ERS852471_02790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267543.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00383">
        <property type="protein sequence ID" value="CUP00383"/>
        <property type="gene ID" value="ERS852471_02790"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP00383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="73" mass="7980" checksum="8DA68474FE6FF37F" modified="2016-09-07" version="1">MCICDLKLGEKGIIDKINGDSKLAKRLSALGCIEGTEIELKRIAPLGDPIILNLRGFDLAIRKKDAKNICLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JUY6</accession>
    <name>A0A174JUY6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267570.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00960">
        <property type="protein sequence ID" value="CUP00960"/>
        <property type="gene ID" value="ERS852471_02803"/>
    </dbReference>
    <dbReference type="OrthoDB" id="138893at186801"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="22278" checksum="E73213075D7A0D84" modified="2016-09-07" version="1">MSLLKYTPFIILIYFSLKLLSKFIEENIISLKEQISNEKIEKGILSIKDLQQSNYDRFLKAIKFYLSTHNYENIIIFKDNSPELTNLKGILNGENIYITCIQNETATDSTNETLFTLTTKKDIESFLGRMISNGCKKGILINNSSFSEDACNFARELNESSNYEIKLVDGYELTKSIRLYKNCNIELEVSNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7K2</accession>
    <name>A0A174K7K2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 12">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 12">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hemA_2</name>
        <name evidence="8" type="synonym">hemA</name>
        <name evidence="16" type="ORF">ERS852471_02953</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 12">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 12">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 12"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267848.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08133">
        <property type="protein sequence ID" value="CUP08133"/>
        <property type="gene ID" value="ERS852471_02953"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="15">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="14">
        <location>
            <begin position="179"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="13">
        <location>
            <begin position="315"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUP08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="47260" checksum="48116F54437BB152" modified="2016-09-07" version="1">MDIYMTGINYNNADIEYREKFSLTTEQQDIIAKKLIDSKIAKGCIFLSTCNRTELWISGNNSLSLDFFINEVLGDEEIDFLIKEDIKKCFIVRQGEEAVDYLLELACGIHSQIFGEDQILTQLKVATDNARKSGYIDSILETLFRTAITGAKKVKTEVILTNKNRSLPETIISQLEGMYGSLKEKKCLVIGNGEMGRLMASNLVDVGANVEMTLRQYKKKQAIIPSGCGVVLYEERCNGIEEKEFIFSATRSPHYTIKREEISELLNKEKMYCFIDMALPRDIDPKIDELSNVRLFHIDDFGVRSECEKEDLESAREILSEYKQDFINWYQIRALAPKVNEISEIVGELTHCKLTKVYKNINISEDDKGFLQSSVQAATKKAVSKIIFGLRENMDREQYNELLKALELTANNCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8H6</accession>
    <name>A0A174K8H6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3867)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05529">
        <property type="protein sequence ID" value="CUP05529"/>
        <property type="gene ID" value="ERS852471_02896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024218">
        <property type="entry name" value="DUF3867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12983">
        <property type="entry name" value="DUF3867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP05529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="183" mass="21907" checksum="C3CDFC108A61AAC1" modified="2016-09-07" version="1">MDRVIDFNELKNKVNDKDIDKFESYIYDLYYRMAEGKINMADFNREISSYMEKNNISQDKFMKIQAKLMERYGFDSAALEEQMKSLGLNNITPDDYEKGRRMMSFQEKYKSRIKVRAASEYYIKNEKNNINIWLEDVDVIIRSEGKIDLTDVELNEFLCSYKKVVDERSLKISICENTKEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KAY8</accession>
    <name>A0A174KAY8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 14">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hemB_2</name>
        <name evidence="16" type="ORF">ERS852471_02950</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 14"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267842.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07991">
        <property type="protein sequence ID" value="CUP07991"/>
        <property type="gene ID" value="ERS852471_02950"/>
    </dbReference>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUP07991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="327" mass="36387" checksum="B74F03EBD47E6EC0" modified="2016-09-07" version="1">MDLINRPRRLRSNPFVRSMVRETKMNIKSLVYPIFIKEGTGIKEEISSMENQFRYSIDMLPQVLKEIVDSGVQNVMLFGIPDKKDPLGTGAWSEDGIIQRALRVAKKECPELYYITDVCLCEYTSHGHCGMLKGQEVDNDSTLPLLAKTALSHVQAGADMVAPSDMMDGRVAAIRSILDENGYENIPIMSYAVKYSSSFYGPFREAAGSAPSFGDRKTYQMDYHNRKEAMREALLDISEGADIIMVKPALSYLDIIRDVANEVNVPVAAYSVSGEYAMIKAAAKMGFIDEDNIVCETATSIYRAGADILLTYYAKELAQFMKSGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KC63</accession>
    <name>A0A174KC63_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267906.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09654">
        <property type="protein sequence ID" value="CUP09654"/>
        <property type="gene ID" value="ERS852471_02979"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="13003" checksum="59885B6A4733B0E7" modified="2016-09-07" version="1">MNTQFKKGIIELCVLSLISKKDMYGYEVVKEIEADMDVTENTIYPILRRLTKEGNFSTYTKVCEGSKERKYYKITEEGKIHYENMVKGWSDFVVSVNKVLSYEYKDSKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KMM0</accession>
    <name>A0A174KMM0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cxxc_20_cxxc protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268067.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13404">
        <property type="protein sequence ID" value="CUP13404"/>
        <property type="gene ID" value="ERS852471_03063"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045019at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="11742" checksum="D76E1E3043B7A76D" modified="2016-09-07" version="1">MICPECNSKFKLRNRIKSMVRKYGKIECSKCKSIFREERNLGTVNTSISMGLIVLLCNSINLLIGGLLKNKFVAISIAIFAALIVVPPVMFLAQSWTNYKKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L170</accession>
    <name>A0A174L170_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ureD</name>
        <name evidence="4" type="ORF">ERS852471_03098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268131.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15319">
        <property type="protein sequence ID" value="CUP15319"/>
        <property type="gene ID" value="ERS852471_03098"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1764668at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP15319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="32127" checksum="AA17707B5B1E2A90" modified="2016-09-07" version="1">MEQLVKKEYAGTIELVLEQKDNRVITTKKYYEGLVKVSANIRNDRERIPTYYLLQLGGGYIEGEKYKNIFILKDNTRAIITTQASTKVYKCEHGDKVLQETTIELGKNSILEYIADTVILYKNAIYKQVNNIYLDESSTLIYSDGITAGWSPEGDKFAYSNVQLKSNVYINNKIVLLDNLIVNPRENDVTKLGFFEEYLNFGTLLIINKNITSNVIEELRREVEKLNLPIDFGISELEVNGFVLRVLGNLTQHIESAMSVCHNYIRKNFLGSKDLVMRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L7Y2</accession>
    <name>A0A174L7Y2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18806">
        <property type="protein sequence ID" value="CUP18806"/>
        <property type="gene ID" value="ERS852471_03166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="51" mass="6123" checksum="3B2D336EFF97CCD3" modified="2016-09-07" version="1">MEQENMSKKSENYRGIYKDMVEVLGHDITLKVYESYKGQQITFPMRLYSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LB18</accession>
    <name>A0A174LB18_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268242.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18739">
        <property type="protein sequence ID" value="CUP18739"/>
        <property type="gene ID" value="ERS852471_03164"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="208" mass="24282" checksum="27E1B5D014007EDC" modified="2016-09-07" version="1">MFNKDNVFITVNEEVSSIIQQYIIREIKKVLDKYKSITTEEISSIEKLINSISNEELKEEFLNDWSMSVKIAKEIGENEVDDRVISMYQNLKSNGLEELSIGHVINWYNELDEQGYVMIDDYSIIYKSSANLKDVARRLLDELLDDAIYVNSLIDKDSLVEYWIEQTSKEDVIDDLIRGSNIEELLGLAPETIYEDEYNKYLYSEIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LDG0</accession>
    <name>A0A174LDG0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsG</name>
        <name evidence="10" type="ORF">ERS852471_03224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117019.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22143">
        <property type="protein sequence ID" value="CUP22143"/>
        <property type="gene ID" value="ERS852471_03224"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP22143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="17620" checksum="14D6540EB7EA304C" modified="2016-09-07" version="1">MPRKGFIAKRDVLPDPMYNSKVVTKLINNVMEDGKKGVAQKICYEAFEIMAQKTGKDALEVFEEAMNNVMPLLEVKARRIGGANYQVPIEVRPERRQTLGLRWILAAARKRGEKVMAERLAGELLDAANNTGAAVKKREDTHKMAEANKAFAHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LQD3</accession>
    <name>A0A174LQD3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_5</name>
        <name evidence="5" type="ORF">ERS852471_03260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268414.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23930">
        <property type="protein sequence ID" value="CUP23930"/>
        <property type="gene ID" value="ERS852471_03260"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP23930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="32677" checksum="6F68EA77678F12FB" modified="2016-09-07" version="1">MNAIKIKNLQKDYKDFSLNIKELNVPTGYITGFIGPNGSGKTTTIKSILGMVKPTNGNIEVLDCDISKDIKIKQDIAYVGDVSGFLEESKISSLHKVISNFYSNWDEELYKKYINEFKVNEDKAYKDLSKGQKKQFELIMALSHHPKLLIMDEPTSSLDPLIRNDFLELMQRHMELDNMTVFYSTHITTDLDKAADYVVMIYNGNIILQDEKDSILENHIIVKIKKDLLDNNLRKEFISLKENSFSFEGLMSNKDKAYELFGDEAIYEKCTLEDILMYYTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M366</accession>
    <name>A0A174M366_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_03324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000045">
        <property type="protein sequence ID" value="CUP28239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28239">
        <property type="protein sequence ID" value="CUP28239"/>
        <property type="gene ID" value="ERS852471_03324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP28239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="66" mass="7824" checksum="22E4DC2B96215044" modified="2016-09-07" version="1">MKDLKEVYKAPTEELALAQLDKLKEAWGNSYGMVIDSWYNNWNNLSNFFDFSPRIRKMIYTTNALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJR7</accession>
    <name>A0A173XJR7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase assembly chaperone HypC/HupF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hypC</name>
        <name evidence="2" type="ORF">ERS852471_00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262720.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50668">
        <property type="protein sequence ID" value="CUN50668"/>
        <property type="gene ID" value="ERS852471_00035"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2031925at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="73" mass="7903" checksum="916E87C8B054B34E" modified="2016-09-07" version="1">MCIAVPAEIKKINGDIALVSYGGVALEVNISLIEEPKIGDYVLIHAGCAIEKICREEAIKTLEIFRELADAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XK82</accession>
    <name>A0A173XK82_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262746.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52064">
        <property type="protein sequence ID" value="CUN52064"/>
        <property type="gene ID" value="ERS852471_00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN52064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="100" mass="11114" checksum="3E6110B367EE1AA9" modified="2016-09-07" version="1">MTDFILIILPLILVSIAMILLVNNLKKKNEKKKVSKNETRNQKEDKSEEDYMTLGMTLGMCFGVTIGSIFTNTFGPNSITYGICFGMLGGMVIGMTIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XL87</accession>
    <name>A0A173XL87_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaC_1</name>
        <name evidence="12" type="ORF">ERS852471_00067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262770.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52652">
        <property type="protein sequence ID" value="CUN52652"/>
        <property type="gene ID" value="ERS852471_00067"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1957201at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="11">
        <location>
            <begin position="160"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN52652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="441" mass="50745" checksum="FD769B4D0B8C1184" modified="2016-09-07" version="1">MLDNNQVVLEQEILCSMFRNNELIIKARDSIKPEMFLYDKHMKIYLGILDMVNNKMEVDLVTFIQYHSAEIRNMDGASYISDIYTCNGSDSGFNTKLELLIKNYKKHLYVEMMNKLNGDMALEDIEGELESVKVKVHKCEIKKELDIATQFDDYVNWLYNSERNNGIKSDFIHLDKYLGNFQKGRLITVFARSGVGKTTFSLQLAANMIKNNAKVFYGSAEMTRNQVFNRMAASHLSISSKSIDDDSINNTDKENITKYMTKLLNSSFYVSTETDFNKFINEIKVYKLQNSLDVVFVDYINKYIDFSDKDIMTNKLGKISGMLKTLAMEEDICIVLMAQANRVVDKKGGDMAIEKIDSSDIQDSARIEQDSDQVIALYRNIKLDDKMYRDALFKKGKLKYSSKNADENPECINAILIKNRHGDRGTCALKWNGRYSRVTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNF4</accession>
    <name>A0A173XNF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262742.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51958">
        <property type="protein sequence ID" value="CUN51958"/>
        <property type="gene ID" value="ERS852471_00052"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="517" mass="60480" checksum="11A16F7DBCC59350" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQ41</accession>
    <name>A0A173XQ41_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262764.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52528">
        <property type="protein sequence ID" value="CUN52528"/>
        <property type="gene ID" value="ERS852471_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021229">
        <property type="entry name" value="DUF2800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10926">
        <property type="entry name" value="DUF2800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="180" mass="20674" checksum="0CBD4EEBE6DDF383" modified="2016-09-07" version="1">MVNNNVNLRENEKIVKDLTVLKLKKNFGFIKNDEYEEELIDLTTDYELTDFSETLSKIAFKAVLKEVENMELEGEDVKVLLNEKLELHCDGVVTEVNADVILMSKDSIEVIDIKSFDYDFINSSQDIDIKLLGLATIDKFLTSITNDKIRLTIIQPNLMTASIYETNIMSLLHQCEYNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XX65</accession>
    <name>A0A173XX65_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 5">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hutI</name>
        <name evidence="7" type="ORF">ERS852471_00137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262901.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55880">
        <property type="protein sequence ID" value="CUN55880"/>
        <property type="gene ID" value="ERS852471_00137"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="230"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN55880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="419" mass="46056" checksum="2772B9158040B249" modified="2016-09-07" version="1">MSLILKNISSLVTCRGSYGKTKDEMKDAGIIANGYIVIENEYIKEIGEGDGYLKYLNNEAVSIDCNGKTVTPGLIDCHTHIVYSGSREKELKLKLNNKSYIDILKAGGGILSTVRSTRNASLEQLIKESEIRLNNMLLHGTTTIESKSGYGLNLKDEVKILKANKKLNDTHPIDIISTYLGAHAIPEEYKYNREKYIQEIINNHIPYIVDNNLAEYIDVFCEIGVFTVEESKRILEAGISKGLKAKIHGDEIESIGGGELAGELKATSAEHLVAISDKGIVSLCENNVIAVLLPSTSFYLMLNHYADARKMIDNGVKIALSTDCNPGTSPNESLQFTMTLACYGMRLLPEEIINAVTINAACAINREKEIGSIEVGKRADITVFNSNSLEYLIYHIGSNAVDKVIKNGKIVVESGKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXG1</accession>
    <name>A0A173XXG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LexA repressor</fullName>
            <ecNumber evidence="9">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lexA_1</name>
        <name evidence="9" type="ORF">ERS852471_00151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262924.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56631">
        <property type="protein sequence ID" value="CUN56631"/>
        <property type="gene ID" value="ERS852471_00151"/>
    </dbReference>
    <dbReference type="OrthoDB" id="956130at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="8">
        <location>
            <begin position="354"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN56631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="476" mass="55404" checksum="BFC5B5BB871C4665" modified="2016-09-07" version="1">MKLTKGQNRFINNKSMGVSFLKGKNNSGKTTASLYRTINLENNYCIYNEDRILYLALNNDSANNIKSKYNEIKDKNYFYSLFSSIDEKVTILSLPELILEYSNKYKMYNDMKLVYKNKESLIQLIKDEDFNDIITAYGKKSKLIKNLPLESLLEEILWIKSCDFTFEEYMNCSRTGAIKRLRKNSISRKLLYNLMEMYNKKMLQNKFMDKYDRVKFAKEFSKNVNEKFKHIIIDGGEKITRCELQFISSLYNISSTSSLTFTINTEETTEIDSWFVKGKKTTYLEEEYKNKTYILKGLPINNEAKKVDYMEKFKYINLKHKNEFDFNIDSLGGTKEIYLEDNLVFKENELKEIPVFNQIAAGNPIEINDEMRETFYLPAGWLERGKDTFILEVKGDSMIDKNIFSGDLVVIKKQHTAYNNDIVAASLDGEATLKILNTNGKYPKLIPANNRYSEISLVDKEVSILGVAIGIIKHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ73</accession>
    <name>A0A173XZ73_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M16 domain-containing protein</fullName>
            <ecNumber evidence="5">3.4.24.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptrA_1</name>
        <name evidence="5" type="ORF">ERS852471_00165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.55" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262951.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57301">
        <property type="protein sequence ID" value="CUN57301"/>
        <property type="gene ID" value="ERS852471_00165"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="165"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN57301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="418" mass="47344" checksum="FF140C7A48971B1E" modified="2016-09-07" version="1">MFTLYTLDNGLRVVTEYIEHVNSISIGVMVQNGSRNETKDENGISHFIEHMFFKGTEKRTSKDIVQEIENIGGQINAFTSKETTCYYLKSLNTQMDLCLDVLSDMLLNSKFDAEEIEKEKGVVIEEINMSEDNPEDVLDDIHSKAIFGDSTLAYPILGTIDRIKSFDREKIKNYIDRHYTPSNSVISICGKFDIDELKKKIEHYFGGWKTTDKYTPQYTIPTLHNDSAFTEKQIEQLHINLGLQGLPYADDKSYSLLLLNNVFGGGASSILFQKVREELGLCYTVYSYPQTYLGVGTLNIYTGLSKQFADNALEVIDRELKMFSKNGICEETLKINKEKIKASYILGLESTSSRMFANAKSVLLQNKIKTQEDVINKINKISNEDINCVLERCFKPGIISSAYVGQSVDITKLNSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0W9</accession>
    <name>A0A173Y0W9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsO</name>
        <name evidence="5" type="ORF">ERS852471_00163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262947.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57200">
        <property type="protein sequence ID" value="CUN57200"/>
        <property type="gene ID" value="ERS852471_00163"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN57200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="87" mass="10151" checksum="53CFD489EC718DE1" modified="2016-09-07" version="1">MDKIRKQEIINEFGRHEGDTGSPEVQIALLTERINSLTAHLKMHKKDHHSRRGLLMMVGQRRGFLNYLAAQDIERYRAIVSKLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3Y6</accession>
    <name>A0A173Y3Y6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ispH1</name>
        <name evidence="5" type="synonym">ispH</name>
        <name evidence="6" type="ORF">ERS852471_00187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58383">
        <property type="protein sequence ID" value="CUN58383"/>
        <property type="gene ID" value="ERS852471_00187"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN58383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="31402" checksum="FED65722C9FED548" modified="2016-09-07" version="1">MKRKVILAESAGFCFGVQRAVDQTVKIQKDYGKKIYTLGPLIHNNDVVKYLENNDVFSISIDNIDELSKGDAVIIRSHGVSKAVMDLLESKGIITIDATCPFVTNIQKKVNKYSKEGYQIVILGDKDHPEVIGINGWCDNKAIITKDGELPERIPNKICVVSQTTEKEENWVNTIRNLSVRTKELLAFNTICAATEIRQKGVFELSKTVDLMIVVGGKNSSNTTKLYQIAKMNCKRAIHIENSSELSTEIINDSTINKIGITAGASTPDWIINEVVELMEGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3Y8</accession>
    <name>A0A173Y3Y8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3267)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263013.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58882">
        <property type="protein sequence ID" value="CUN58882"/>
        <property type="gene ID" value="ERS852471_00196"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2179949at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021683">
        <property type="entry name" value="DUF3267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11667">
        <property type="entry name" value="DUF3267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="23945" checksum="FD4DECF33DE9DFAD" modified="2016-09-07" version="1">MTLEKGIFLRAKDEYDCEFILSPISNFNRTTYLNLRLLIRTILSLPLALYLGYSLYYTCNSIVDIKSFILSFIITYILSFYLIQIPHELIHYIIYSNFLSDQKAKIKLFNRKRLITSTYNGEINYTRSLLGLIAPVLIISSILSVILILKGFNIVIYGVMWANLIISAEDILNIFIYISSNDVSKGIYELPNDYNYLINEMQKQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4S9</accession>
    <name>A0A173Y4S9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lexA_2</name>
        <name evidence="12" type="synonym">lexA</name>
        <name evidence="16" type="ORF">ERS852471_00197</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263015.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58924">
        <property type="protein sequence ID" value="CUN58924"/>
        <property type="gene ID" value="ERS852471_00197"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="82"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN58924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="22525" checksum="986DE15EC1920FF8" modified="2016-09-07" version="1">MIENSNKQMEIYEFLKNFTELKGYPPSVREICEAVNLKSTSSVHGHLKKLETKGLIKRDPTKPRALEIMENSLNKIEMVNIPIIGKVTAGIPILANENVEGVFPVPLSYIKHDKELFMLNVSGDSMINAGIHHGDLAIIERNPTACNGDIVVALIENEATIKTFYKEDDYIRLQPENDTMDPIIVKDCSILGKLVGLFRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAP0</accession>
    <name>A0A173YAP0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative selenate reductase subunit YgfK</fullName>
            <ecNumber evidence="6">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltD_1</name>
        <name evidence="6" type="ORF">ERS852471_00218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60065">
        <property type="protein sequence ID" value="CUN60065"/>
        <property type="gene ID" value="ERS852471_00218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017701">
        <property type="entry name" value="Se_rdtase_YgfK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03315">
        <property type="entry name" value="Se_ygfK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN60065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112520" checksum="BE0950ECCC6FEACB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRY3</accession>
    <name>A0A173YRY3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">ERS852471_00293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263207.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65976">
        <property type="protein sequence ID" value="CUN65976"/>
        <property type="gene ID" value="ERS852471_00293"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="80"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN65976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="31614" checksum="636EE04752E996A6" modified="2016-09-07" version="1">MVEGNIKSNTSKYIVDKITRVIFLICALVAVVSLILIIGFVFMKGLKPFVTGDKSFIEFIFGTDWYPTSEVPKYGILPMIIASIYGTVGALIIGVPIGLLTAIFIAEVAPKGVSKFMIPAVELLAGIPSVLYGLFGLAIIVPWIQRTFNLAQGQSLFAVIIVLAVMMLPTIISVSTTAIKAVPKSYKEGSLALGASHIETTFKVVVPAAKSGILAAIVLGSGRAIGETMAIILVAGNSVQIPTAIFDKVRPLTSNIALEMGYASQAHQELLFATGVVLFAFILILNLVISKLSSKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXX5</accession>
    <name>A0A173YXX5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methyltransferase RsmD</fullName>
            <ecNumber evidence="3">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsmD</name>
        <name evidence="3" type="ORF">ERS852471_00324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.171" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263265.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67815">
        <property type="protein sequence ID" value="CUN67815"/>
        <property type="gene ID" value="ERS852471_00324"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN67815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="20898" checksum="3896B0999FE3F870" modified="2016-09-07" version="1">MRIIAGKARGRKLIPPATMETRPTLDRVKESMFSIIQNHIPDAVVVDVFAGTGSLGLEAASRGAKEVYLVDRSKDAFSLLKQNIENLKFEDTCYALNKDSYEALKYLADKNKVFDVIFIDPPYCREMIPEAMKIIHDRKLLNEDGIIVTKIDSIEEIYEGNDNIALFKSRKYGNTTICLYKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAE0</accession>
    <name>A0A173ZAE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263421.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72630">
        <property type="protein sequence ID" value="CUN72630"/>
        <property type="gene ID" value="ERS852471_00415"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2079651at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN72630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14701" checksum="D0AF37C47F20BB71" modified="2016-09-07" version="1">MEINNFVTTDFLASFTGTLFVVELIVFVTKNLPIIKKIRTRFYTFLLAISHIIIMGLVTKTATQTVIYYYGVFINSLIVTVMLCGGYDIIIDKIYSVTNIQPKDTNNNIDDKSIEDSSNKNDTNNSNEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBG5</accession>
    <name>A0A173ZBG5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferredoxin-NADP(+) reductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrK_1</name>
        <name evidence="4" type="ORF">ERS852471_00435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263458.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73641">
        <property type="protein sequence ID" value="CUN73641"/>
        <property type="gene ID" value="ERS852471_00435"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN73641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="32904" checksum="52912778F949FFA9" modified="2016-09-07" version="1">MFKIVDKRLLTDNIYLMEIEARRVAKSAKPGQFVIVKTDEKGERIPLTIADYNVERGTVTIVYQTVGAGTKELAEFEVGEYVQDFVGPLGMPSEFIHEDINELRNKKFIFVAGGVGAAPVYPQVKWFHENGINVDVIIGSRNKELLILEDEMRKVAGNLYISTDDGSYGFNGRVTDCLLDLVNHKGKKYDHAVVIGPMIMMKFMSILTKELHIPTTVSLNPIMVDGTGMCGACRVTVGNEVKFACVDGPEFDGHLVNFDESMRRQSMYKTEEGRAILKMEEGDTHHRAGCGCGGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJY5</accession>
    <name>A0A173ZJY5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_1</name>
        <name evidence="7" type="ORF">ERS852471_00470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263521.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75538">
        <property type="protein sequence ID" value="CUN75538"/>
        <property type="gene ID" value="ERS852471_00470"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="34873" checksum="7CCF9E76C0853F49" modified="2016-09-07" version="1">MDINTSTNKEKVKIKYNKFNKLAVKEWIAAYIFLLPALAFFVIFVVIPMGEGIIMSFMNYTLRKKEWIGLGNYIKIFNDPVFKKSLVNTLVLVLGNVPCVLIFSLFVATTVYKRSSKMRSFFRSVFYLPAIASVVSITVVWGWILHPNYGILNYIIEQFGGTPQLWLSNPTIAKWAILIILVTLSVGQPIVLYMASLGNIPKDYLEAAEIDGANSRQVFWNITWPMLKPTSLYIFIITTINSFQCFSLIQLLTAGGPNYSTTTIMYQVYEKSFTLGQFGLASSMGMVLAVIVILISIIQYKFLGSGIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZRV4</accession>
    <name>A0A173ZRV4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN78984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263583.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78984">
        <property type="protein sequence ID" value="CUN78984"/>
        <property type="gene ID" value="ERS852471_00492"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1385409at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN78984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="23457" checksum="A42C74CF055B9396" modified="2016-09-07" version="1">MEILDKSFYSIDALTLSKKLLGKVLVNEVNGKIFKGIIVETEAYIGAIDKASHAYGGRRTERTETLYGEPGIVYVYSIYGMYFCFNVICGEKDVAEGVLIRGLEPLEGLDEMSLNRFNKHYEELTKAQIKNLTNGPSKLCIAMNINKSNNTKELIKENSLYIEDYNIEVLPSNIVETTRIGIDYAEEAVHFPWRFYIKDNPYVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZUM7</accession>
    <name>A0A173ZUM7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclomaltodextrinase</fullName>
            <ecNumber evidence="3">3.2.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.2.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263595.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79513">
        <property type="protein sequence ID" value="CUN79513"/>
        <property type="gene ID" value="ERS852471_00501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047798">
        <property type="term" value="F:cyclomaltodextrinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="137"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="575" mass="68066" checksum="2CF94BD5F0AD5220" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5T5</accession>
    <name>A0A174A5T5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">modB</name>
        <name evidence="10" type="ORF">ERS852471_00552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83523">
        <property type="protein sequence ID" value="CUN83523"/>
        <property type="gene ID" value="ERS852471_00552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="24941" checksum="7DBD7E4FCC583226" modified="2016-09-07" version="1">MSMNLSPLWISIKTAFLATIITFILGVAAAYWIANSKNKLKGLIDGLFTLPLILPPTVIGFFLLLICGKNGPVGKFLLNFDITLIFSWTATVIAATVVSFPMMYRTSRAAFEQIDINVISAARTLGLSEMKIFFRIALPLAWPGIIGGLVLSFARAMGEFGATLMLAGNIPGRTQTMPLAIFFAVEGGDMKTAMLWVLIIVAISLFMIVILNYWSDIQLKLMGRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ADE4</accession>
    <name>A0A174ADE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yurK</name>
        <name evidence="2" type="ORF">ERS852471_00594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263765.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86652">
        <property type="protein sequence ID" value="CUN86652"/>
        <property type="gene ID" value="ERS852471_00594"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="13889" checksum="A36C4D5E957B22CC" modified="2016-09-07" version="1">MNLEFTNDVPIYIQIAQAIEDNILKDIFKENEMIPSTTEISVKYKINPATVGKGFNILVDEGIIYKKRGIGMFVAEGSKDLLMNKRKERFFKDYIVALIEEAKKLNISKEDIIKMIEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AK72</accession>
    <name>A0A174AK72_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin containing amine oxidoreductase</fullName>
            <ecNumber evidence="5">1.4.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">puo</name>
        <name evidence="5" type="ORF">ERS852471_00611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.4.3.10" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263797.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87888">
        <property type="protein sequence ID" value="CUN87888"/>
        <property type="gene ID" value="ERS852471_00611"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050232">
        <property type="term" value="F:putrescine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN87888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="466" mass="52881" checksum="74750E635CE2FBB1" modified="2016-09-07" version="1">MEGDHKKEKPKIVIVGAGLAGLTCAYRLFKSGIKCKVFEASERVGGRCFSIRNYFLDNQIAEHGGELIDSEHNEIKELAKEIGLKLENLIDIDKKENKPFYFFNGQPYSYDEASKDWLSVYPRVRKDYEDVKFPTLYNKYTNRGYELDNISVRQWINQIIPEGVNSNLGRLLDVAYSVEYGAETNTQSALNIVRLLGSGEENAFNIFGSSDRMYHIKGGNDQLPGRLYRALPKGTVKFKTQLLSISKVKYDKYKLVFQSACKVASVLADIVVLAIPFSVLKLSVNYDKAGFSELKKQAIDELAMGTNTKLNVQFTSRYWRRVNNNGTTYCNIGYQVTREGSCGQLGTKGILVNNTGGKIGASYNNQEYIKQYVETFINRLDRVIPRRNAKWNGKAILDYWTGNRWTLGSYPYYKLGQYTKFAGVEGESEGNCFFAGDQTSIYYQGYMNGAVESGERVCKEILERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ARG8</accession>
    <name>A0A174ARG8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative rhoptry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263870.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90459">
        <property type="protein sequence ID" value="CUN90459"/>
        <property type="gene ID" value="ERS852471_00654"/>
    </dbReference>
    <dbReference type="OrthoDB" id="829448at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032721">
        <property type="entry name" value="Toxin-deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14424">
        <property type="entry name" value="Toxin-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN90459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="377" mass="44305" checksum="7B9C069B76E79E51" modified="2016-09-07" version="1">MREDNITLNKRKKVRIDICTIRDFKEASLKEGYRLKEIEDNNLKKEIIEVFNVDEKVADKLHSFIKDEEHTFRADNINSFIDYIEKIVLFEDNHKKLCRQIKGIKRLHIDREEYEREPSIQDDVDEIINIIETLKPKISSVIDKSGIDKIYNIEKELSKYYVYAKDIELLKRMISNKNDKIFENYNVQKRVKTLSIDIPKELNKDYIKATKGTVEYHQHLNNNIPRMERLIKNLNKYMKSHESEIKSFKIDQSEALQDTINIAIASFNGKEFKAISGKNNIRGYCNAPYLGKAAFEACKVNKLGKLGVGYKRVNDSEKKIFEEIHKQISGGELKDNGELILYSKWEPCPSCYYVISQFCEMHPNINVKVKYHKKYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BA32</accession>
    <name>A0A174BA32_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ORF">ERS852471_00724</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264012.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96596">
        <property type="protein sequence ID" value="CUN96596"/>
        <property type="gene ID" value="ERS852471_00724"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN96596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="323" mass="36740" checksum="DF25504419BAA5E4" modified="2016-09-07" version="1">MKDKFKREIDYLRLSVTDNCNLRCIYCMDEKENNFLKTSEKLSDEEILRVVKSCAEVGIKKIRITGGEPLVRPNITKLIDSINNIEGIEEIYITTNGILLADKVEALAKSGVKGVNISLDSLKEDRFKSLTRRGELSKVLEAIDKCIEFGIKVKLNTVMVNDINHDEIKDFIKLTINKPIDVRFIELMPIGVGKVYKGVSNQEIRDIIKDNFANAVEIGKEKSSGPAKYIKIDGALGKVGFISAMSNCFCEECNRVRITPEGFLKQCLHFDYGVSLRDLIREGISNEELKKKIEETIYNKPEKHLFNQNKEHEEIRFMNQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGN2</accession>
    <name>A0A174BGN2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1292)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264093.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98910">
        <property type="protein sequence ID" value="CUN98910"/>
        <property type="gene ID" value="ERS852471_00767"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1976605at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="12215" checksum="1A11819AF6CC69AC" modified="2016-09-07" version="1">MDNELNKCGCGESCGCDHDHNNEGCGEGCGCGEHEHEHMVVDLEDDNGNVISCPIIDAFEYEGEEYVLAQDPEGDSIYLFRATESGELVVPDEAEFDKVADYYSNVLAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIQ6</accession>
    <name>A0A174BIQ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264119.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99620">
        <property type="protein sequence ID" value="CUN99620"/>
        <property type="gene ID" value="ERS852471_00781"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1439364at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025945">
        <property type="entry name" value="DHHW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14286">
        <property type="entry name" value="DHHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="366" mass="43373" checksum="148171AF14F351E3" modified="2016-09-07" version="1">MKRNYLLYSFFIVLALLSILDIIKPDKTFSDLENRNLKQKVKFTVEGFWDNSFQQNYESYINDQFIFRDGWIDIKSRSEFCLGKIENNGIIYGDNEYLFEKYSNFEKSRFLNNIEAINIFKNNISSNISLMIVPNSYEIYKELVPKAAPLVPQEENIDYIYDNVLETNNIKLFDVMTENKDKYIYYRTDHHWTAYGAYLAYKEFIESIGEKPIELNQEDFVEVDDFYGTYFSKAKPFNVKPDIFSYLDLSGVTMNISGEEFDSIYDYSQLELRDKYALFLRGNNPLTIIKNTNLQNGKKIVVIKDSYANSLVPYLTQNYEEIHVIDLRTFKEQVGQYVDENDIKDVLILYNFINFTRDVNIIRLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJL4</accession>
    <name>A0A174BJL4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264182.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01192">
        <property type="protein sequence ID" value="CUO01192"/>
        <property type="gene ID" value="ERS852471_00810"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="286"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO01192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="48924" checksum="AF15647BAF217FC4" modified="2016-09-07" version="1">MGRIKDYIIKRRLLIIILLVIIVAGVGIINVGVAKAEERKRISIIEDLISEGSYDDAIEKIDELTEKYSYKLDKKITDYRSILETYRYIDSCKDSIEIKEIIELLKEDYSELLKDNIFIKLNESLLQKQSDIDNHIKEMENINIFKVQIEEAIDRDIEEAKTLIEIFKRDYPDEDILALENKLKEKIGNIEKEKELLKEDETVIEEVEYEKDINNSTGIQENKLGIANTVAAQNSSQIITVVSNGGSYGELVMWQKDGNGNWFEVDRVAARLGQNGMKYASEVYEMDKCTPTGIYTVTEAFGINGNPGSGVPYRELDGSEYWVDDVDSEYYNTMQFGDPNGRWNSAEKLVDFPGYYNYSLVIDYNRWPVIPGKSSAIFLHCDMGIYTYGCVAIPQNNLVNLLTWLDPNSNPVMILDFTYEDIYNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNW3</accession>
    <name>A0A174BNW3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264222.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02317">
        <property type="protein sequence ID" value="CUO02317"/>
        <property type="gene ID" value="ERS852471_00832"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1771582at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="174" mass="20094" checksum="47E8618D7B7CDC6D" modified="2016-09-07" version="1">MKKHVTNLAGNNLYLDVYGNTVYYNIFDKKGYIISKEVEQKFRLLYYRYSIIVIVLILLGDYFKSLQNTLIIGVGAVVLVELYFRGIYLKKLKSIKDFKRDKKVSKLEVIVRSKEKEKIVMKACAYMLLSILIVLNAIQQNFNIVFMILSGIVAIYSIYSGVLNIVAVNKMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C1G0</accession>
    <name>A0A174C1G0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD-dependent malic enzyme</fullName>
            <ecNumber evidence="8">1.1.1.38</ecNumber>
            <ecNumber evidence="8">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">maeB</name>
        <name evidence="8" type="ORF">ERS852471_00899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="8"/>
    <dbReference type="EC" id="1.1.1.40" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264360.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07212">
        <property type="protein sequence ID" value="CUO07212"/>
        <property type="gene ID" value="ERS852471_00899"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="7">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="6">
        <location>
            <begin position="160"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO07212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="42012" checksum="54C136A6A14AB5DD" modified="2016-09-07" version="1">MSIYEESLKFHEELRGKFEVVSRAKVDNEKDLSLAYTPGVAEPCREIAKDPNNAYIYTRKCNTVAVISDGTAVLGLGDIGPLASLPVMEGKSILFKNFADVDAFPIVLNTKDTDEIVETVSRIAGSLGGINLEDISAPRCFEIERRLKEKLDIPVFHDDQHGTAIVVLAGIMNALKIIKKEPSDLKVVMSGAGAAGVAIAKLLLSFGVKNIVMFNKEGIIDRNKEYTDPSLVEISKITNPNNESGTLADSIKGADVFVGVSAPNLLSTEMVSTMNKDAIIFAMANPVPEIFPEDAKKGGARIIGTGRSDFPNQVNNVLAFPGIFRGALDVRASDINEEMKLAAAHAIANEVSEEELSEDYILPKALNKNVAKAVAEAVKQAAIDSGVARIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C880</accession>
    <name>A0A174C880_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase, family 25</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acm</name>
        <name evidence="2" type="ORF">ERS852471_00946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264455.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09721">
        <property type="protein sequence ID" value="CUO09721"/>
        <property type="gene ID" value="ERS852471_00946"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO09721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="35536" checksum="7393CCE6B66F9134" modified="2016-09-07" version="1">MQNKNDKSLFGVDINEYTQNVDFTVLATKIDFLYLRASGSASGRFRRDNKFLEFAQKSREYGIPVGAYHFGVPADDLTTADAQCDDFIEVLQEGFGKKDYGDLFPVIDVEVPTDKSLAVETVVNWIDRFRKRFEKKTRRRIMLYTGTFYVELYNNFFIPGRGYPLKNMILWIAMYTAIPGNPAYPPDVGGWTRWRVWQYSESANVQGIGNPVDANWGPNSIDYLIQPRSVTGLRATKRGNTINIRWNANTDADLLGYNLFANNYWIGTVDANDTEFTIPVSSLPFTQSGPIKISIEAFDLDGETSRVRTTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CX67</accession>
    <name>A0A174CX67_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat peptide assembly protein CotJB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264610.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18091">
        <property type="protein sequence ID" value="CUO18091"/>
        <property type="gene ID" value="ERS852471_01085"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1848060at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024207">
        <property type="entry name" value="CotJB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12652">
        <property type="entry name" value="CotJB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CotJB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="81" mass="9632" checksum="8B57B64B03E59688" modified="2016-09-07" version="1">MSENPLLVEIMKYIFYAVELNLYLDNFPNNTEATEDYRNISAKLDELVRKYEKQYGPLTNFGSASYENPKAWVNCQWPWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEC0</accession>
    <name>A0A174DEC0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264684.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22276">
        <property type="protein sequence ID" value="CUO22276"/>
        <property type="gene ID" value="ERS852471_01170"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1916223at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="152" mass="17585" checksum="E34CFCC0765D124B" modified="2016-09-07" version="1">MRTFFINSYEIKKLCCLFFAGEVIMYALIGPFIGADSISFSLIWQMAAISILLTMLQYVLYTFNFMNKVKREVKVLIHYFILIGLGYGFAKVFNWFNLNDLNNIIIAVSIFTVCFIITAGSIYIYTKLTGERFNERLKVYKELKKSNEGEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFR4</accession>
    <name>A0A174DFR4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264695.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22776">
        <property type="protein sequence ID" value="CUO22776"/>
        <property type="gene ID" value="ERS852471_01182"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1561228at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019981" evidence="2">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO22776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="194" mass="21022" checksum="0112B0896EA7372C" modified="2016-09-07" version="1">MKTKSLVLALFLGVALLVGCGNNGTTNDTTNKGATTEEKENTNTNNPGDADVVSSASLASDEETLKKALKDSWIVLLKNDITTSKDLVVEGDFTKPDKNDSSKMVPAGRTIALYENDDNNTTKSYTLTTPKITVKSKDTKIEGGTIIGDVYVEAEGFELENAKIEGNVYFSKQEYKDSFEMDDKSTVTGVQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQ15</accession>
    <name>A0A174DQ15_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264745.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26195">
        <property type="protein sequence ID" value="CUO26195"/>
        <property type="gene ID" value="ERS852471_01226"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2057244at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="88" mass="10540" checksum="9122273F82D4D1BC" modified="2016-09-07" version="1">MEKENLEQEEKQIMTFLDEEGNKVEFEAIARIFLEEQEYLLLAPADDEESEDVYVFRIDNVEGKEELNLVEDDKEFLAVKKEYKKLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTD7</accession>
    <name>A0A174DTD7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xanthine dehydrogenase molybdopterin-binding subunit B</fullName>
            <ecNumber evidence="4">1.2.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xdhB2</name>
        <name evidence="4" type="ORF">ERS852471_01250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.99.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264785.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27386">
        <property type="protein sequence ID" value="CUO27386"/>
        <property type="gene ID" value="ERS852471_01250"/>
    </dbReference>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033727">
        <property type="term" value="F:aldehyde dehydrogenase (FAD-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017697">
        <property type="entry name" value="Xdh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03311">
        <property type="entry name" value="Se_dep_XDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO27386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="851" mass="93311" checksum="5C186DB998181E70" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVA0</accession>
    <name>A0A174DVA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264867.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29403">
        <property type="protein sequence ID" value="CUO29403"/>
        <property type="gene ID" value="ERS852471_01294"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421771at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="226" mass="24558" checksum="B4609FD9B2566538" modified="2016-09-07" version="1">MDTNILGIIISFIFVLSIIGISTILTKKRIISGEASRKFIHIGVCNWWIIAMIYFDNRYYAAIVPALFVVINYISYKYKVIEAMERDGGKKDLGTVYYAISLLILALLTLGDSGKGYIGALGILTMGYGDGFAAVVGTFKGTKYIPIGRNLKSKEGTLTMLVATFAVITLILGVCTDISITGVILYAVVLSVVATLLELFTPHGLDNLSVPLGISLIYYIISIFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIA4</accession>
    <name>A0A174EIA4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfcE_2</name>
        <name evidence="5" type="ORF">ERS852471_01415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265079.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35700">
        <property type="protein sequence ID" value="CUO35700"/>
        <property type="gene ID" value="ERS852471_01415"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="232" mass="26103" checksum="82B3089891D7BC6B" modified="2016-09-07" version="1">MKIAAISDIHGNLYALMKVLEDIDEQKVDKIICLGDLVGYGPHPNEVVALIRRREIPCIKGNYDASVVDGDYTYIRNTTINSFSLPWAVNEVRVSNKYYLDSLPLKLEYSINGVNIVFTHGSPEKINEYLFENGENTVQAMNNFTGDVLVCAHTHIPSCKKFDNKLYINVGSVGKPKIGRPNCTYALIDISDDGEVNVSIREIEYEFKRIVKDCAMLNFPNSITHSYESGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJB2</accession>
    <name>A0A174EJB2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metS</name>
        <name evidence="8" type="ORF">ERS852471_01437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265119.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36636">
        <property type="protein sequence ID" value="CUO36636"/>
        <property type="gene ID" value="ERS852471_01437"/>
    </dbReference>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="7">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="7">
        <location>
            <begin position="120"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO36636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="483" mass="56591" checksum="1CE0CAB35A466D77" modified="2016-09-07" version="1">MNIIIGNAWPYANGPLHLGRIAVWLPGDILARYHRMMGDNVVFISGTDCHGTPVTNRAEEEGISPLEAVEKYHKEFQKCFKSLGFSFDIFEKTHSEYHQEKVKKFILDLYEKGYIYEEIVDGSKHLFFALSKFEDDVKYIFDNEDGWRENAKKILKRYLDEGLRDRAVTRDFNWGVDVPLDGYEDKKIYVWIEAVMGYLTASMKCLSERGEDWKEYWSGDDSRVYFVHGKDNIPFHTVIFPAILCGVGIKNPNLRMISSEHLKLEGKPFSSVKNWALWADYITKNYNVDSFRYYLMLNSPEDKDTDFSWRDYINVNNFDLVSTFSHYVQRVITFSRKNYGPRIPSGIIEESLKNEILDLYFSVGDDIEEGHFNSALNNIMAFCRKANKDFKENLLWDMAEKNPDYCKNKVYNNIQIVANIANLLEPFMPNICENIRTSLSINEPIWSFIEKRDGILKEVDLELKRIDKRRAIDEVLRLKEKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJY0</accession>
    <name>A0A174EJY0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore maturation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spmB</name>
        <name evidence="2" type="ORF">ERS852471_01443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265127.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36856">
        <property type="protein sequence ID" value="CUO36856"/>
        <property type="gene ID" value="ERS852471_01443"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1757687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="174" mass="19361" checksum="5AE088099803A02D" modified="2016-09-07" version="1">MFQYITKSIIPIIVFIIITYGMFKGRKVYDWFVEGAKDGLKVCMNIFPYLLAMILAVHIFREAKLLDMLNNLISPISGLIGLPKEVVPLVLVKPLSGSGAMGIFTDILKNYGPDTFIGLVSSVIMGTTETIFYTVTVYFGAVKIKKVRHTVWAAVMADMTAIIMAILMVKILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELK9</accession>
    <name>A0A174ELK9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1836)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265206.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38922">
        <property type="protein sequence ID" value="CUO38922"/>
        <property type="gene ID" value="ERS852471_01487"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1504619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014975">
        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40056">
        <property type="entry name" value="PTHR40056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="22362" checksum="C669AAD4D83950EB" modified="2016-09-07" version="1">MDINELINDMDFINGIAMDDIPEIDLYMDQVIQLFEGKLSSLKRTEDDKILTKTMINNYAKGKLLLPIKNKKYTKEHIILMSLIYNLKGALSINDIKLSLNKIIDSFSEDESYPLRELYGSFLDESENDVLEFKKGVADKEREIEALIESKSDLQGDFEKKFLLLCSFVNMSNMYRRASEKLIDEFFSEVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQA2</accession>
    <name>A0A174EQA2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265202.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38848">
        <property type="protein sequence ID" value="CUO38848"/>
        <property type="gene ID" value="ERS852471_01485"/>
    </dbReference>
    <dbReference type="OrthoDB" id="819609at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="144"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="50165" checksum="514D3D8BB3F6D69D" modified="2016-09-07" version="1">MDISNSKSFSENKFNFKNNIKFIIPSLLGVLLFMTPISYNGDITIPVAILSNKLTELLGGSLPYIIAATLAISGIMTFITSVFKPKFILENNFLKSLFSTTPLWAISRIVGSIFGVLTLLQVGPEFIISDVSGGFVFNDLLTILFSIFLFAGLLLPLLLNFGLLEFVGSLLTKVMRPLFKLPGRSSIDCITSWLGDGTLGIILTSKQYEDGFYTEREAAVVSTTFSAVSITFSLIVIQTIGLNGMFIPFYLTVTFAGIVAAIIVPRIPPLSKKKDIYYKGKKAENSSEDVPEGHTSLSWGYKCAIEKASQNSDAKNFFVEGFKNILDMWMGVLPIVMCFATIALVIAEFTPIFRILGLPFVPVLQLLQVPEAVAASQTLVVGFADMLLPSVIASTTITNEMTKFIIACVSVTQLIYMSEVGGVLLGSKVPVNLKEILIIFVERTLVTLPVIVLIANFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETW2</accession>
    <name>A0A174ETW2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">chbF_2</name>
        <name evidence="10" type="ORF">ERS852471_01495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265222.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39440">
        <property type="protein sequence ID" value="CUO39440"/>
        <property type="gene ID" value="ERS852471_01495"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="199"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO39440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="453" mass="50435" checksum="A5FC29EEEA8D70FA" modified="2016-09-07" version="1">MSKKGLKIVTIGGGSSYTPELVEGLIKRYSELPVAEYWLVDIEEGKEKLEIVGALAKRMVEKAGVPMEIHLTLDRKEALKDADFVTTQLRVGLLKARAKDERIPLSHGFLGQETNGAGGLFKALRTVPVILDIAKEMQDLCPNAWLINFTNPAGVVTEALLRYSDHKKVIGVCNVPIGMEFGAADLLGVDKSRITMDQVGLNHMVYGQRVYLDGNDVTAEVMEKMLNSDNSQSMANIAAMGWDPAFIKATGLMPCPYHRYYYKKRDMLEHELEEYKKGQTRAEVVMAVEKSLFELYKNVELQEKPEELSKRGGAHYSDVACEVISSIYNDKGTVLAVNTKNNGRLKMFEDESAIEISCKITKDGPVPVDTVTDLPIFAQGLVSQIKAFERLAAEAAYTGDYNTALLAMTTNPLVSDDTEGRKLLNEMLLAHKKYLPQFKNVIEQIEKVERAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZP5</accession>
    <name>A0A174EZP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41989">
        <property type="protein sequence ID" value="CUO41989"/>
        <property type="gene ID" value="ERS852471_01527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO41989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="373" mass="42413" checksum="D4B01C62EB93155A" modified="2016-09-07" version="1">MIRKFSAVSLLIIIVLPLLLTGCFNYRDINRVTFSTSIIFDVDELGRTIIYLDCIKPYRSTNDSSDKGKRIIYKGEGKTVVEALSNINMISGYKLNYSQTKAYIFTERAAQKGIKKFLDLINDNNEFQMKSSAFVYYGDVQELLKITSSDEEYLGLFLNELVKTDNNDAKFIKSNINYYLSNTLMGSNTLMLSAMKLKKDAIDEKVEIGEGAVFKNNRLVENMPAEDVVAYNLLTRNIKQGNLEIPNPQSDDGFITLQILDSNVKDSLKYEGGKFILVKDIGIDVSVAEAQEQFVVDSDVLNYITKNEEAFVNEYAKFIFNKYKDKDLDLFDIKRMVEVYYPKSEIANPLKYTDIEVNTKVTIKGTGVTRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F522</accession>
    <name>A0A174F522_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265396.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44771">
        <property type="protein sequence ID" value="CUO44771"/>
        <property type="gene ID" value="ERS852471_01583"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1326945at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021350" evidence="1">
        <location>
            <begin position="28"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="93"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="219" mass="25010" checksum="9C433EF0971EF4BA" modified="2016-09-07" version="1">MRLLKCLSCMFIAIMFLGINELSVSAAMKIIPGYYEDDLRYFQNEIKVPEEIIIKEKIKEVTYNPDNLREISNLSKEQIYKMLEGNNLQALAEDYYEMEQKYNVNAIFLMALNMEESGHGRSSLAVYNNNLGGIKSRNGGYASFESWSHCLEYIANLIDEMYLSETGSYYNGTSIYGVNVKYCVGTNWADNLNVLADELLAKVEPNTNTNTNVMIMHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6J2</accession>
    <name>A0A174F6J2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell envelope-related function transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lytR_1</name>
        <name evidence="4" type="ORF">ERS852471_01575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44426">
        <property type="protein sequence ID" value="CUO44426"/>
        <property type="gene ID" value="ERS852471_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="88"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO44426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="325" mass="36535" checksum="9BD33A0C61ED9559" modified="2016-09-07" version="1">MGWVMTKRKRKKKYSIGKKILLGFLSFICILVLVGSIVIINLSSKINTVEIDRSFVTDTGKEPIKEEKDVITIALLGSDYSGTEIGASDATMILSIDTKKNNIKLLSLMRDIYLDLPDGGKQNLNYTLVDGGPELLLKTINYNFNLQVDKFVHVSLHTLPIIIDKLGGVELEITNEELNFINGYIKNIDSENGTITEPLYGSGKQLLNGTQAAAYCRIRYTEGRDYKRTERQRDVLSAIFDKFKNISITEVPGLINDLLPLVSTNMTTSEMLSIAIKALGTGVSNIEQGRFPLDEHHYAEWTDMYHMIIDIDATTEEIHKFIYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8K7</accession>
    <name>A0A174F8K7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265416.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45288">
        <property type="protein sequence ID" value="CUO45288"/>
        <property type="gene ID" value="ERS852471_01594"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="7058" checksum="3C35790BC155C389" modified="2016-09-07" version="1">MHCVRCGKELDFTIKFCSNCGKEVIIGENEESFLVKEYSIRDRMQIIELFNNAKKKENEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FD92</accession>
    <name>A0A174FD92_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ugd</name>
        <name evidence="13" type="ORF">ERS852471_01622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265469.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46629">
        <property type="protein sequence ID" value="CUO46629"/>
        <property type="gene ID" value="ERS852471_01622"/>
    </dbReference>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="12">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="388" mass="43769" checksum="7C6B010FA0804027" modified="2016-09-07" version="1">MKIAVAGTGYVGLSNAILLAQNNEVVAVDIIQEKVDMINDRISPIVDKEIEDYLSNKELSLVATTDVFKAYKDAEFVIISTPTNYDPELNYFNTRSVEAVIANVLSINPEATMVIKSTVPVGYTKKVREMFETDNIIFSPEFLREGKALYDNLYPSRIIVGEQSERARKFASLLSEGAIKEDIPTLFTDSTEAEAVKLFSNTYLALRVAYFNELDTYAELRGLNTKQIIEGVGLDPRIGSHYNNPLFGYGGYCLPKDTKQLRANYADVPNNIIGAIVEANTTRKDHIADMVLARKPKIVGIYRLTMKTNSDNFRASSIQGIMKRIKAKGIEVKVYEPTLRDSHFFNSEVVKDIERFKEECDVIVSNRLSEELFDVEEKVYTRDLFGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDT6</accession>
    <name>A0A174FDT6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetyl-mannosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.187</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tagA_1</name>
        <name evidence="1" type="ORF">ERS852471_01620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.187" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265465.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46500">
        <property type="protein sequence ID" value="CUO46500"/>
        <property type="gene ID" value="ERS852471_01620"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="27912" checksum="A88D540140FCEED5" modified="2016-09-07" version="1">MSRIKFLNTEVDNLTMDEALERIDELVISKKPSYVVTPNVDHIVKLETDNEFKDVYKEADLILTDGMPLIWISKLNGNPIKEKVSGSDLFPNVCKLAAKKGYKVFLLGAAEGIAIKAGENLKSKFKGLDIVGTYSPSYGFEKKPEEIKDIIKIINQANPDILAVGLGAPKQEKLLFKYRKELNVPVSLAIGASIDFEAGNINRAPRWMQNSGLEWLYRLCKEPKRMFKRYLIDDMKIFKIYMKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNZ8</accession>
    <name>A0A174FNZ8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265583.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50598">
        <property type="protein sequence ID" value="CUO50598"/>
        <property type="gene ID" value="ERS852471_01684"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO50598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="17004" checksum="72A1CA314D96F500" modified="2016-09-07" version="1">MKIDYKLMDSSHINGVFELSKICFNVPWSLDSITYEIENPLAKYVIAEDLSTKEVIGYAGVWIVAGEGDITNIAVNPSYRKKGIASNLLIKLLEVCKEHNCTDITLEVRTSNIAAQNLYKKFNFKEEGIRKKYYSDNGEDAIIMWKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTG9</accession>
    <name>A0A174FTG9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat protein, CotS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cotS</name>
        <name evidence="1" type="ORF">ERS852471_01745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265690.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53493">
        <property type="protein sequence ID" value="CUO53493"/>
        <property type="gene ID" value="ERS852471_01745"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="338" mass="40166" checksum="A15CAC556FF7372B" modified="2016-09-07" version="1">MVKTRYVDKNILCEYDFKEEFINLLGIKINDVIPLRKVFVLFTDKGKKVLKITDSTKDRIDFIDKVLKIIESEYPMVLKYTRNTNGDIITVWKGKKYVLLDMVEGREATFTNPIEVELCTKAIAKMHIASNNIFKNISEEEIKKNSGENLINKMEEEYYTLLQLEELVNKYRYKNEFDNLFLQNVDNAKKDLIKTIEELKNSRYESLINNKENRVLCHNDLAHHNFIIDGDKVNIIDFDYCSIDMRIVDIYGYAMKVIKNLAYNEEIIELIIKSYDEVNKLEKEEVEILRKLINYPKDFISIATDYYFKQKAWSEEVFLSRLKNKLEIDKFRIEFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTY3</accession>
    <name>A0A174FTY3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apbE</name>
        <name evidence="11" type="ORF">ERS852471_01751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265703.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53752">
        <property type="protein sequence ID" value="CUO53752"/>
        <property type="gene ID" value="ERS852471_01751"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021063at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948328" description="FAD:protein FMN transferase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO53752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="353" mass="38866" checksum="DA21F762F24C9A27" modified="2016-09-07" version="1">MFKFKKYSKSLLCLSLVFMLVGCGQNTKKNEQTTQQEPIKRTEMLMGTVISVTLYDSTDETILDKVFDKVKNLEETLSINEAGTEVDKINENAGIEPVKVSDDTMEVVKEGLYYSDLSHGKFDITIGPLVKLWNIPDRPTEDIPTQDEIDAVLPLTNYKDVVVDENNKTVFLTRPGMMLDLGGIAKGYTADVISKMLTNEGVKSAIIDLGGNIFAHGEKVSGDAWKIGIQNPFSTRGEIVGAISTKNKSIVTSGVYERYIEVNGVKYHHILNPETGYPYENNIAGITIISDKSTTGDALSTSVFALGVDEGIKFVEGLDGVDAIFVTKDNGIYLTSGIKDNFELRNDNFKVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G811</accession>
    <name>A0A174G811_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265858.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58523">
        <property type="protein sequence ID" value="CUO58523"/>
        <property type="gene ID" value="ERS852471_01830"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1657762at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016977">
        <property type="entry name" value="Competence_ComGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15980">
        <property type="entry name" value="ComGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="17901" checksum="36AB01FE44E3CA00" modified="2016-09-07" version="1">MKEKKNKRGFTLIELLVSLGIFTIITTVSFNIIISATKEYVLYINKSTELDNLDNCLINIDNILRSDYIIAINVEGDKIEIVSKMVHKGKSIKKKIIYKKDNNLMVKTLINDDLDTSTGNNVLLKNVKDFNVLQKDELIYFEIITKSEERRIRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH85</accession>
    <name>A0A174GH85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Accessory Sec system protein Asp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265912.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9clot-a0a174gh85">
        <property type="family name" value="Asp2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59825">
        <property type="protein sequence ID" value="CUO59825"/>
        <property type="gene ID" value="ERS852471_01860"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1576959at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO59825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="260" mass="30436" checksum="D8BCA442B4C1AECF" modified="2016-09-07" version="1">MSLLIKVEKAVDLLKTKCLMKFKQRIYSGKKYNIKYLFEEKKGSKDLLIGFTACTKVGQKARYNYIKTLEEFKCNKLFILDDFGFDERGAYYLGKDRDFAIEKDVESLINDICKKIEPKKEFYIGSSKGGYAALYFGVRRKDTYIVVGAPQYNLGNYLNLPGHTEILKYIMGNCNQESISILNELLKEALIKNKENKNKIFLHYSDKEETFESDLKPLIDELINLNYESEFDLEHYESHAELTKYYPQYIKKILSKNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJ20</accession>
    <name>A0A174GJ20_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dapA2</name>
        <name evidence="9" type="synonym">dapA</name>
        <name evidence="11" type="ORF">ERS852471_01893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265968.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61178">
        <property type="protein sequence ID" value="CUO61178"/>
        <property type="gene ID" value="ERS852471_01893"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO61178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="31889" checksum="4CF07DC7316184C2" modified="2016-09-07" version="1">MSIFKGSGVAIVTPFNDSGVNYNKLEELLEWHISEGTDAIIICGTTGEATTMTEEERKNTIKFTVDVVKNRIPVIAGTGTNDTTKSINMSKYAESVGVDGLLIITPYYNKTNNKGLIKHFEAINNSVNTPIIAYNVPSRTGLNITPDQLLMLSTLNNVIAIKEASGNISQIAKMKALCGDSIDIYSGNDDQIIPIMSLGGLGVISVAANIVPKVIHNIASEFLNGNYDEALKLQLGYLELCNMLFIETNPIPVKTALNLLSKNVGNLRLPLYEMDDTNKIKLFKTLENYNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZ19</accession>
    <name>A0A174GZ19_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnulokinase RhaB</fullName>
            <ecNumber evidence="4">2.7.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhaB_1</name>
        <name evidence="4" type="ORF">ERS852471_02004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266169.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66437">
        <property type="protein sequence ID" value="CUO66437"/>
        <property type="gene ID" value="ERS852471_02004"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="255"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO66437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="475" mass="53378" checksum="8399B39427DC0F35" modified="2016-09-07" version="1">MSNFLAFDFGASSGRAILVKIEKDYIDMKEIHRFPNEPVFLGDKYVWDFPRLLNETKTALKKVVASGTKITSIGIDTWGVDYGLLDKDNNLIGMPMHYRDERNYEGVKEVEKKIDLERLYLRTGISNNTFNTAFQLVGDRLKRNTILENADSLLFMPDLFAYYLTNEKKNEFTIASTSGLLDMKNRTWDKELINALGIPENIFNEIIEPGETYGYLTDEVMDETGMDRVPVIAIGGHDTASAVAGTPFKNKGNAFLSSGTWSLLGLEIDSPIISEETFKASLTNEGGVGNKIRLLKNINGTWLLQQLRKNWCEFHEEIGFPDIIREAKKYEDCTFKVNTNDPRLMNTKNMIKSIKEYCIEHGQGEPTELGEIAMAIYNGLTSEYKATIEELEEISGREIPGINVVGGGIQDKFLCELTMKRTGKTLIAGPIEAAVLGNVMIQAIANNEIESIEEGRELIFNAFSCEVYSQEVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDZ0</accession>
    <name>A0A174HDZ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
            <ecNumber evidence="1">2.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mak</name>
        <name evidence="1" type="ORF">ERS852471_02148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266443.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73064">
        <property type="protein sequence ID" value="CUO73064"/>
        <property type="gene ID" value="ERS852471_02148"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="32825" checksum="143DE88A485F880D" modified="2016-09-07" version="1">MNKLTLGIDIGGTFIKYALVDSAFNIIEKWKIPTVKCNTKDEFYDYICSNAKYLDEVDRIGVSAPGLVNEASEIKSYAAPNVVIMFGTSVNEEISKRTGKIVATINDAKSAGLCELKAGNAKGTKSSAFLIIGTGTGGCLCNEDDVIYGVDGFAGEFHHMPFIDFHENKVLRQGDYCSMTALIQIYNTKVSEDERLEYGHEITAKYLAGDEVAKLAIEDWTRNIANQLLSITTFYNPEIICLGGGISEEDWFIDLISERFKVASKNFLGLDILTTKIGRCKYNNDANILGAVIKVNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGY5</accession>
    <name>A0A174HGY5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3785)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266500.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74173">
        <property type="protein sequence ID" value="CUO74173"/>
        <property type="gene ID" value="ERS852471_02179"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024210">
        <property type="entry name" value="DUF3785"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12653">
        <property type="entry name" value="DUF3785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="16340" checksum="901C25D0C71C5975" modified="2016-09-07" version="1">MEYTCKFDEKEYILNEENLYCFFNDEENPINDVDEKKIIEILNNSDKVDFSKAYFNLACENCQTGVEEKKKFFDFLGYNFYIFTKNGKYVVSNIEPQYEGSTYDKLYALGKVDNSYLVTINVCKHCGEYSIEIEEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJI3</accession>
    <name>A0A174HJI3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">crp_2</name>
        <name evidence="4" type="ORF">ERS852471_02154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266454.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73318">
        <property type="protein sequence ID" value="CUO73318"/>
        <property type="gene ID" value="ERS852471_02154"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO73318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="229" mass="26569" checksum="250D288CABB89B00" modified="2016-09-07" version="1">MVKISLEELKDMELFQELSDETLKLLSEHCDMKEYKKGSHVFRDREIVSRIYILYSGKVSLYKMNESAQKKIIFILGAGKIINDYAIDDLPSSINCEVFETAQILSIDKKIFLEIMKSDFDLTKIFIKAQALKIRRLYRQMKNSTPIKVEKRVAAKLWKLAKDYGEEVEEGTLIKLNISVTYLADMFGAPRETISRALKLLSKEDLIINDNKKIIIKDKDRLSKFFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJL4</accession>
    <name>A0A174HJL4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate reductase, catalytic subunit</fullName>
            <ecNumber evidence="7">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">narB_1</name>
        <name evidence="7" type="ORF">ERS852471_02149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266518.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73115">
        <property type="protein sequence ID" value="CUO73115"/>
        <property type="gene ID" value="ERS852471_02149"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
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        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO73115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="695" mass="78080" checksum="C42DF399CECAA9B8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJU9</accession>
    <name>A0A174HJU9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase, NADH oxidase subunit</fullName>
            <ecNumber evidence="6">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thcD</name>
        <name evidence="6" type="ORF">ERS852471_02151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266448.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73205">
        <property type="protein sequence ID" value="CUO73205"/>
        <property type="gene ID" value="ERS852471_02151"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="316"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="410" mass="45130" checksum="47B4E8EDC672FA8C" modified="2016-09-07" version="1">MRYVVIGASAAGISGVKTLRELDKDAEIILVSKDENVYSRCILHHYISNHRDVEALNFTDKKFFEDNNITWIKGVEVKSIDDKAQSLELSNGETLTYDKVMLCTGASAFIPPVEGLREGNNVVGLRNLDDAVLIKEQAKKVKNVVVLGAGLVGIDAVSGLLGQGLNVSLVEMGDKILPIQLDKYTSDVYQKKFSENGVNLKLGVRAEKLILDENKNPKALVINTGNGTEEIPCELVIVATGVRSNTAFLEGSNIEFDRFGLIIDEKGKTNIDNVYGAGDITGRNPIWPTAVKEGIIAANNMLGNEMIMTDFFGSKNTMNFVGIATMSLGDTEPKDETYKVEVKIDGDNYKKIIHKDGKIYGALIQGDLSYAGVLTQLIKENIDISKVTKSIFDIDYADFFNMKENFEFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HL85</accession>
    <name>A0A174HL85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_02172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266488.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73918">
        <property type="protein sequence ID" value="CUO73918"/>
        <property type="gene ID" value="ERS852471_02172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO73918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="315" mass="33048" checksum="D3F6091BC5DFDA22" modified="2016-09-07" version="1">MWTIIQQIFPYAIAYTIPLLIAALGALYCERSGIVNIGIEGLMVVGSFAGAFTISKLQAAGVPGALWIGLLVAALVGMLFSLLHAFASINLSANQVISGTAINMIAGALTVFLARNLTGSGNIRVTLGFIPKDIPVLSDIPVIGPLLFTRSYITTWLVLLILAIFTFLLYKTSFGLRLRACGEHPQAAAAAGVNVYKMRYIGVMISGAFAALGGAIILVTYSGEFNGNVAGLGFLAIAALIFGQWKPLGILGATLFFGFATTLANVSQAIPELSSIPQVALKVFPYVVTLIALIIFSKSSQAPKAAGETFDAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HSA8</accession>
    <name>A0A174HSA8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Type IV leader peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">outO</name>
        <name evidence="10" type="ORF">ERS852471_02230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266574.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75960">
        <property type="protein sequence ID" value="CUO75960"/>
        <property type="gene ID" value="ERS852471_02230"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="9">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="8">
        <location>
            <begin position="102"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO75960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="252" mass="27890" checksum="5699333FBAC16610" modified="2016-09-07" version="1">MELFFVVLFGLCIGSFLNVCIYRIAREESISFPPSHCTSCGYELKPKDLVPVLSYAFLGGKCRSCKEKISIRYPLIELLNALLYVVIYLNYGFSFELFKFAVFASLMIVIGFIDFDTKYVFNSTVIFGVISGIVFLLAEWIITKNILWTNIVGAAVGFGIIWAIVALTGGMGEGDIDIALICGLFLGIKGIVVTLFLAFIFGGVIAVFIMVLKLKDRKSEMAFGPYLAIGGMIAMLYSTQLIELYLNLLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTE0</accession>
    <name>A0A174HTE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">etfB</name>
        <name evidence="3" type="ORF">ERS852471_02242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266599.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76398">
        <property type="protein sequence ID" value="CUO76398"/>
        <property type="gene ID" value="ERS852471_02242"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO76398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="259" mass="27981" checksum="0A0AA5FB0B6371D0" modified="2016-09-07" version="1">MNIVVCLKQVPDTTVVKIDPVKGTLIREGVPSIINPEDKNALEAALQIKEKNGAHITVISMGPPQAKEALREALCMGADEAILLTDRAFGGADTLATSKTLAAAIKTLDYDIIFGGRQAIDGDTAQVGPEIAEHLEIPQVTYVQNVEFDGSDLIVNRALEDGYELIKVKTPCLLTAIEELNHPRYMNVGLIFDTANKEVKIMTSADLDVEANEIGLNGSPTKVKKSMTKEAKGAGEIVKDSVPEAVSYVLSRLKEKHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTQ9</accession>
    <name>A0A174HTQ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">glcB</name>
        <name evidence="15" type="ORF">ERS852471_02284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266671.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78293">
        <property type="protein sequence ID" value="CUO78293"/>
        <property type="gene ID" value="ERS852471_02284"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035550at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019866">
        <property type="term" value="C:organelle inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015572">
        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010974">
        <property type="entry name" value="PTS_IIBC_nag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01998">
        <property type="entry name" value="PTS-II-BC-nag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="6"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="422"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO78293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="501" mass="54614" checksum="DBB3D19372D84C3A" modified="2016-09-07" version="1">MGSKINKLLNFFQLLGKAIMIPIAALPVAALMLRLGKADVWGPNLFGGNGIPWMVAAGEAVINQMNLLFAIGISVGLADDNNGSAGLAGAIGYFVFTNVTYSFAEQLYQGSSIIDMGVLAGMIAGIVAGLLYNKYKEIRLPQFLGFFGGKRFVPIVTSFVMLLLGLVFGGIWPNIQESINSFGNTIATSGIIGAFIFGFLNRLLIPFGLHHALNSIFWFQFGEFTTANGEVVTGDMVRFLSGDPTAGIFQTGFFPIMMFALPAACLAMILAAKKNRRKAVTGMLVSIAFTSFLTGITEPIEFSFLFLAPGLFLIHAILTGLSLAVTSFLGIRAGYSFSAGFIDYLLNFNLAERPILLILVGVVMGIIYFIIFYFCITKFDLKTPGRDEDDDNIEECKEKEEVNVNKLEDKEVAIKPLRSKLDKIAECIIDAVGGKNNIEHVDSCITRIRLQLKDSNKVEKSKLKQIGATEIIRLGKNNVQIIIGTVADPVVSRIRRIIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HV92</accession>
    <name>A0A174HV92_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluF_2</name>
        <name evidence="5" type="ORF">ERS852471_02262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266640.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77068">
        <property type="protein sequence ID" value="CUO77068"/>
        <property type="gene ID" value="ERS852471_02262"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO77068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="30089" checksum="6CCF4678A2543427" modified="2016-09-07" version="1">MKQNSQKRNNIIIHNDRPDDIRLNKYISESGYCSRREADKLIESGRVTIDNVKATMGTKVSKGQVVRVDGKKIYKDEELVYIALNKPVGITCTTEHKVKGNIVDFVNHEKRIFPIGRLDKDSQGLIFLTNDGDIVNKILRAGNNHEKEYIVTVNKPINDEFVKRMSNGIRILGQVTKKCYVKKEGNNTFRIILTQGLNRQIRRMCEALGYEVTKLKRVRIMNVNLDDLKIGQWRDMTEKELKELNRLISTSVKTKDAEQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZG0</accession>
    <name>A0A174HZG0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YhiN family flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266761.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80294">
        <property type="protein sequence ID" value="CUO80294"/>
        <property type="gene ID" value="ERS852471_02346"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO80294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="45344" checksum="DF3820D4F0EB7DAA" modified="2016-09-07" version="1">MIYHDLIIVGGGASGMIAAITAKDFGIDVAIVEGTDRVGKKILTTGNGRCNISNRCVAEPFINYHSNCDNFFSSVLSQFGVDDTLNYFLSLGLPIVPLKGGKLYPQSLQASSVVDILKMSLEDRNIPLYTSCKIKDIHKGKVFKLSTSNEEYKLFTCENLILACGGKSAPKTGSDGSAYYLAKNLGHSITKLLPGIVQLKLKYEHLKALSGVKFDGYAKLFVDDKEVKEDFGEILFTDYGISGPPILQISALASQATSNSKKTEVIVDLMPNYTKDELIDFLECHFALLSHRPIINAFIGVINKKIIPVLLKECGITDLHMPCYELSWKEKNKLIQTLKGWKFTCIGTNDFNQAQVTIGGVDASEINPDTLESKIVPNLYFAGELIDVHGDCGGFNLQWAWSSGYVAAKSIANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I0I7</accession>
    <name>A0A174I0I7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266711.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79107">
        <property type="protein sequence ID" value="CUO79107"/>
        <property type="gene ID" value="ERS852471_02310"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1426624at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="307" mass="33256" checksum="E2F2D87788E95D82" modified="2016-09-07" version="1">MFIINFIRGFFMALADSVPGVSGGTIAFILGFYDDFINSLNSLISRDNMDNKKNSLIFLFKLGIGWVTGMVLSVLFLSSIFDAQIYKISSLFTGFIVVSIPLIISQEKDSIVGKYKNILFTIIGITIVALITYFNPASSNGGLNLSLDSLSIGLGIFVFVAGMIAISAMVLPGISGSTLLLIFGLYTGIIGAVKEVLTFNFSYLPILIIFGLGVLTGIATTIKVIKFVLKKYRSQTVYLILGLMIGSLYAIFMGPTTLEVAKPAMNLSSFSFIFFIIGGALILGLERLKVVFESKETKNISKNRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1L3</accession>
    <name>A0A174I1L3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266727.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79467">
        <property type="protein sequence ID" value="CUO79467"/>
        <property type="gene ID" value="ERS852471_02320"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1960160at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO79467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="11640" checksum="EC6AB98DBCFCEC0A" modified="2016-09-07" version="1">MGKITSKNNDLLRDAKQKTSPKIYSLLLDLVNDGREDLAEMVLKIDYLIEYANKSIKAKDFEEAKEAIQKAEERTKMLKRAKADVEHLTYLIEGVNKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1S2</accession>
    <name>A0A174I1S2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">celB3</name>
        <name evidence="11" type="ORF">ERS852471_02315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266721.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79308">
        <property type="protein sequence ID" value="CUO79308"/>
        <property type="gene ID" value="ERS852471_02315"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="11"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO79308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="434" mass="47173" checksum="C83D309967FD150D" modified="2016-09-07" version="1">MSFFDKFQSGIEKVMGPFANVVSTNKFIRALTAGFMATMPISLGTAAIAVLGNLPITPWQNFLVSMGLYQVAQDFISLTLSLLAIYVVISISYNYTKIEGKNAITGAVVSAAVFITLMPIKTSEIDGVMATSLLTSNMGSNGIFVAMIVGLLTPWIFCKLMNKNLKLKLPDSVPPMVADSLAPTFVAMILFFGVFMIKWGISLTSYGDIFTFITEVISKPVMYFGTSPWALIFMYCFMNLCWFFGIHPSPILSCYIPVLMAAGTANTEAFLAGQALPYLTFSIVGAAVYVGGNGNTLGLCIATLFAKSEKYKSMRKLVIPANIFNINEPIIFGFPTMLNPLYFIPMVFTSLASGAVAILLVNILPVTLNPTISLPWVTPGFVSSVMSGGLNLLLIWGVSVTIHFLMYLPFFMVDDANAYKDEQEMLKASEIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IC31</accession>
    <name>A0A174IC31_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator with cupin sensor, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ypdC_3</name>
        <name evidence="5" type="ORF">ERS852471_02403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266866.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82928">
        <property type="protein sequence ID" value="CUO82928"/>
        <property type="gene ID" value="ERS852471_02403"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="221"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="37989" checksum="651071447E1B460A" modified="2016-09-07" version="1">MREDILKKLFELTEEEKQILEGEADVDKSIYTDESQFIIDSNKILAKDQLINIRKHTRFVEFPEHKHNYIEFNYVYKGKLTEVIHNKEINLKEGEIIFLNKDITHKIKESSKDDIIINFIIKPEFFDFLLSLSNEENTIFSFLLKSIYMNNNKGEYLYFKVNDERYIQEILEKIIIEIYEPSMISSTSIKLLVGLLIVELIKTPDKIEMYSEDNYDSLMVIDVFKYIDNNYAKATLTEVSERLNQPNYKISKLIKKHTDMTFKELLQEKRLDIAKKLLSDTELPIVEVITSVGYENLTYFYKIFKEKYGCTPNEFKSYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IKU7</accession>
    <name>A0A174IKU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein from nitrogen regulatory protein P-II (GLNB) family, ortholog YAAQ B. subtilis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266974.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85639">
        <property type="protein sequence ID" value="CUO85639"/>
        <property type="gene ID" value="ERS852471_02463"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2052224at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO85639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="11985" checksum="BEF6A2678582A0CC" modified="2016-09-07" version="1">MKLVIAIVQDDDALDLIEELNDKGFRVTKLATTGGFLKSGNTTLMIGVEKDKVNDVVKVVEDVCKMRKEIIPTPTTMSNGTGMYMPYPMEVEVGGATIFVLDVDQFIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IWM6</accession>
    <name>A0A174IWM6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-chelate-transporting ATPase</fullName>
            <ecNumber evidence="5">3.6.3.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fhuC_2</name>
        <name evidence="5" type="ORF">ERS852471_02568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.34" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267151.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90456">
        <property type="protein sequence ID" value="CUO90456"/>
        <property type="gene ID" value="ERS852471_02568"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO90456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="28602" checksum="202E1BF5038960DD" modified="2016-09-07" version="1">MIEVKNITKAYGNKKVVDNVSLKIEEGKITSFIGPNGAGKSTLLSIISRLIKRDSGEVLIDGKDVLEWDNKELAKKVSILRQTNNINIRLTIRELVEFGRFPHCGGNLKKEDIENVDQALRYMQLEDIQDKYLDELSGGQRQRAYIAMVIAQNSDYIFLDEPLNNLDMKHSVEIMKILRTLTDELGKTVVIVIHDINFASCYSDNIVALKNGQLVKNGPATDTIQKEELEKIYEIDFHIENINNRNICVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J3W2</accession>
    <name>A0A174J3W2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein Fur</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur_2</name>
        <name evidence="3" type="ORF">ERS852471_02606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91865">
        <property type="protein sequence ID" value="CUO91865"/>
        <property type="gene ID" value="ERS852471_02606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO91865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="146" mass="16865" checksum="3AC80E8BC27B80F5" modified="2016-09-07" version="1">MNNKPNFSNLLKCKGLKVTKHRNSVLEVIESSKRPVTAEDIYIILKQRNISINLSSIYRILDTLVANSLINKFIFEETNKTCYEMNDMQHKHYLICNGCKKVFPISGCPLHTYESELEDTLGFTITSHKLEIYGFCKECKNNPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J7L7</accession>
    <name>A0A174J7L7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate uptake ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_6</name>
        <name evidence="7" type="ORF">ERS852471_02659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267311.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94276">
        <property type="protein sequence ID" value="CUO94276"/>
        <property type="gene ID" value="ERS852471_02659"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO94276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="30972" checksum="82EBC6E641E0B5B3" modified="2016-09-07" version="1">MNKNSLGSVLKYLVLILFAIVTLFPFYWMIASSLKSSFEVIQTPPTLFPSKIMWHNYSVALKMAPFARYFFNTIIVTILSIISTVIIAILTAFAFSHLEFPGRDMIFSIFLASMMIPGEVLIVTNFKTISALGWIDTYQALFVPYMANVLYIYMLREFFFKIPKQLYYAAKVDGASDWKFLWKIVVPMAKPSIITICILVGINSWNAFLWPLLVTNSEKMRLLANGLTAFQSDAGNQYELLMAASTIITMPIVIVYIFLHKKIMSGVSIGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JF79</accession>
    <name>A0A174JF79_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267407.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96866">
        <property type="protein sequence ID" value="CUO96866"/>
        <property type="gene ID" value="ERS852471_02711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO96866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="303" mass="34080" checksum="D583CA0185AE5916" modified="2016-09-07" version="1">MKNFKILSFDGGGIKGALSTRIILRLTQKYPTLLEDIDLFAGTSTGSIIALYLAYSKNSYAIDNLYNEENIKKIFSKKRPNFFIPKFSSKNLLKELKANFPEDLKLKDLHPYVFIPTFSTNGFTSNSWEPVFLNNLTDNTTAEFSVIDAALASSAAPTYFPSHKGFIDGGVVVNNPTPIASFFALSKLDSISSSSQLRILSIGTGNYPNKIASNTAKWGMLQWAFDPFISIKSPILTILLEGSSLVEDIYCKELFMQNYFRLNPIIPDHIEMDDYKKVSLLKNIADSLDLTELYNYIDNIFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JG78</accession>
    <name>A0A174JG78_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">luxQ_3</name>
        <name evidence="8" type="ORF">ERS852471_02751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO98734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267480.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98734">
        <property type="protein sequence ID" value="CUO98734"/>
        <property type="gene ID" value="ERS852471_02751"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="783"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="844"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO98734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1065" mass="121506" checksum="D063B2979CE15E2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JWC1</accession>
    <name>A0A174JWC1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rlmCD</name>
        <name evidence="7" type="ORF">ERS852471_02815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.189" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267603.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01908">
        <property type="protein sequence ID" value="CUP01908"/>
        <property type="gene ID" value="ERS852471_02815"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP01908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="51810" checksum="20870D1736DD5041" modified="2016-09-07" version="1">MVEKNKEYILDIVSQGYEGEGVAKINDTFPVFIQGALVGEKVRVKIIKSKKNYAYGKLIEVIESSADRCNPKCDVYKRCGGCKLQHSSYKSQLDFKHNRVKDCIEKIGKLNPELVKYPLGMNDPWRYRNKVQLPIGLVNGELKIGFFAERSHEIIDMKNCLIQDELADKVVELTREWIIKNNIKPYNVDGQYDENGILRHIMIRRGFTTNEVMVVIVTNGDKLPYKDEFVNIIKDNVPGIKSIIQNINSKSTNVILGLESKTLWGEDTISDYIGEFRFNISPLSFFQVNPTQTEVLYSKALEYAKLTGNETVFDAYCGTGTITLFLSKKAKKVYGVEIIPQAIDNAWINAKENNVENVEFFVGESEVVIPDLINKGVKADVVVVDPPRKGCDKKLLDAISNIDAKRIVYVSCDPSTLARDLAILDENGYKTLEVQPVDMFPHTAHIENVALLVKKTLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JXH9</accession>
    <name>A0A174JXH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidA_4</name>
        <name evidence="1" type="ORF">ERS852471_02866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267693.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04474">
        <property type="protein sequence ID" value="CUP04474"/>
        <property type="gene ID" value="ERS852471_02866"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP04474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="30007" checksum="EA720D1A91A27187" modified="2016-09-07" version="1">MYKLIALDMDGTLLNEEKIVTERTKKAIQAARDKGVTVVLATGRPIDGVTRYLEELDMYTDNDYVLSYNGGLVLKTKSREVVCKMGLIGEDVHYLYDLSKKLGVNIHAFSEENGLVTPKNSKYTEVEASINNITIQEINFENIKNDESYIKVMMIDEPEILQNAVDNLPKEVFEKYTVVRSTPYFLEFLNKEVNKGVGVELLAKHLGVKREEVITMGDAGNDLHMIEYAGMGIAMGNAFEEVKKAANYITDSNNEDGVATAIEKFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K574</accession>
    <name>A0A174K574_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_17</name>
        <name evidence="6" type="ORF">ERS852471_02933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267813.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07313">
        <property type="protein sequence ID" value="CUP07313"/>
        <property type="gene ID" value="ERS852471_02933"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP07313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="467" mass="51315" checksum="B7D783920F3CC30E" modified="2016-09-07" version="1">MKKSEESKFLGEEKISKLLLKFSVPCILSLLISSLYNIVDQIFIGNSEMGYLGNASTTIVFPITIIAVAFAWCFGDGAAAYLSICQGKKDTKDVHKSIGNSITATFVISLIFVAIGFMFKDEILFAFGASSASIGLAREYFVIILAAIPIYMLMNMMNAIIRADGSPAYSMASMLVGAIINIILDPIFIFVFKWGIKGAAYATIIGQIISFIISASYFFKTKTFKLKLESFKMNFCIFSNVIKLGASTFITQMSIVIISLVCNIMLVKYGSVSKYGQDIPIAVIGIAMKVFTIVINIVVGIVLGGQPILGYNYGAKKYNRVKEAYKIIFISTLIVGIIATLIFELCPQVIIGMFGAESELYNEFAKMTFRIFLSLVTFTCTIKMTSIFFQAVGQPAKAAIISLTRDIVCFVPLVILLPIKMEITGILWAAPIADGIGMIISMIFVTLFLKSLDKNIDKKQLDYKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8Q3</accession>
    <name>A0A174K8Q3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF2935)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05599">
        <property type="protein sequence ID" value="CUP05599"/>
        <property type="gene ID" value="ERS852471_02898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021328">
        <property type="entry name" value="DUF2935"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11155">
        <property type="entry name" value="DUF2935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP05599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="203" mass="23682" checksum="4831F0A48E5ED7EF" modified="2016-09-07" version="1">MLSSQRYITLSLELHLFFARIMKEHSIFLEAGFTPKNSKLSKEADEYKIKFEKLLLDTVKVSQGVNIESVINSGEIFTKYTLSAEKKTQYYTAININFKITSMEQELKCKNKIDFDNKTVKYVKQLNNRGIKLLDGLIDLKKRILDGMLCCELFTLNYPLLIEHIIREAELYRSYIKLLENGDDIEDFNNSEVRKSELFGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K936</accession>
    <name>A0A174K936_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yusV_2</name>
        <name evidence="5" type="ORF">ERS852471_02935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267817.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07381">
        <property type="protein sequence ID" value="CUP07381"/>
        <property type="gene ID" value="ERS852471_02935"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP07381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="266" mass="29876" checksum="E18F9756D4700616" modified="2016-09-07" version="1">MEAISVKNLTVSYENNTIIQDMDLSIPKGKISIIIGANGCGKSTLLKTISRINKPKAGDIFINNKNIKKVKEKDIAKEVAFLPQGPVCPSGLTVRELVAFGRFPHQKMIGGLNSHDKEVIDWAIKETGLSEFADREVENLSGGQRQRAWIAMTLAQETEIIMLDEPTTYLDMSYQLEVLEVLQKLNKEKKITVVIVLHELNNACRFADNIIGLKKGKTVCQGRPLEVINKENLKKIYGIDAKLTESENKEYPICIDYELFRGINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9D1</accession>
    <name>A0A174K9D1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, RpiR family</fullName>
            <ecNumber evidence="3">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kpsF</name>
        <name evidence="3" type="ORF">ERS852471_02926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267801.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07006">
        <property type="protein sequence ID" value="CUP07006"/>
        <property type="gene ID" value="ERS852471_02926"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="104"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="237" mass="27149" checksum="E6B37E1D1C4EC120" modified="2016-09-07" version="1">MIKPEVIKYFSEKEMRIYDYINKNSDKFPYMTIREVADEVSVSTTTILNFIKKIGYPNYSSFKYAYKVKEKKEKSKENKYDFKEVIKCLDKFDSTFYKGKFECAINILRNSDNVIFIGIGNSGIIAQYGARLFSSIGKFSLAINDPYLRVGYLGAKSTIIVLSVSGETPEIIREVKEFKKLGCKIIVIATTENCTLSRMSDVTIPYYIESVYNEFIDITTQMPAIGIIENLSRILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KA51</accession>
    <name>A0A174KA51_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cueR_2</name>
        <name evidence="2" type="ORF">ERS852471_02969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267878.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08842">
        <property type="protein sequence ID" value="CUP08842"/>
        <property type="gene ID" value="ERS852471_02969"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP08842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="260" mass="29937" checksum="6E9392D70A2FA1F5" modified="2016-09-07" version="1">MIIKGVRSIGKTYKTSEVAKLIGIHPNTVRMYEDLELISKPIRKGNGYRVFTDLHIDQLKLARKAFEVEVLQNGLRKKAIAIVKMSAKQDFDEAIVLTKEYIKSIKKEIDNANEAVDIAGKLINRLNHDKDFNLKRKEVSELLGISMDTLRNWEMNGLVNIKRKQNGYRIYTYEDIQRLKVIRSLRCGNYSLSAILRMLNKLSEHNEADINEVLNSPNENEDIISVCDKLIISLNLAAKNAEEILEMLYEIKRKYSNPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLC7</accession>
    <name>A0A174KLC7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1622)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267990.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11296">
        <property type="protein sequence ID" value="CUP11296"/>
        <property type="gene ID" value="ERS852471_03023"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="13136" checksum="8BF62036481855CE" modified="2016-09-07" version="1">MLEELFDIYLPILIHLFELMGIIILTLGTFTAFINYFRGKFSKKDYKVKYEFADVMVTALDFKLSAEILKTVIIRSKEELVILAVVFIIRIIMTFVLEKEMKTQEKKEKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQY4</accession>
    <name>A0A174KQY4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">srrA_3</name>
        <name evidence="11" type="ORF">ERS852471_03082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268105.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14624">
        <property type="protein sequence ID" value="CUP14624"/>
        <property type="gene ID" value="ERS852471_03082"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="25642" checksum="8E7CD3EB6AC6E36D" modified="2016-09-07" version="1">MERNILIIEDEIRIRILLRDYLKKDGFNVIEAADGDEGINTFQNNNIDLILLDIMMPRVDGITVLETIRNVSNVPIILLTAKSQEEDKLFGYELGADDYITKPFSPKVLIAKVKALLKRTSDGVTSFSSAKDFKGLSINKLAHEVKVDGTTLNLSPKEFELLVYLTDNIGISLTRDTILDNVWGIDYYGDLRTVDTNVKRLREKLGSKANYIITVRGSGYKFEVNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KU04</accession>
    <name>A0A174KU04_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III Xth</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
            <ecNumber evidence="4">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">exoA</name>
        <name evidence="4" type="ORF">ERS852471_03106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EC" id="4.2.99.18" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268147.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15684">
        <property type="protein sequence ID" value="CUP15684"/>
        <property type="gene ID" value="ERS852471_03106"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP15684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="29417" checksum="C82BB36B322E09EB" modified="2016-09-07" version="1">MRLISWNVNGIRACVQKGFLEFFKEVDADIFCIQESKLQEGQINLELEGYYQYWNYAERKGYSGTAIFTKVKPLTVSYGINIEEHDKEGRVITLEFDDYYVITVYTPNSQNELARLDYRMKWEDDFRNYLKSLERNKPVILCGDLNVAHKEIDLKNPSTNRKNAGFTDEEREKFSTLLNSGFIDTFRYFYPDLTGSYSWWSYRFNARKNNAGWRIDYFVVSEALKDKLVSAKIHTEIFGSDHCPVELVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXP4</accession>
    <name>A0A174KXP4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureB1</name>
        <name evidence="2" type="synonym">ureB</name>
        <name evidence="3" type="ORF">ERS852471_03103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268141.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15551">
        <property type="protein sequence ID" value="CUP15551"/>
        <property type="gene ID" value="ERS852471_03103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755809at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP15551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="12351" checksum="D42F1F87AC86F688" modified="2016-09-07" version="1">MIPGELKIKEGNILYNEGKDAITLEVVNTGDRPVQIGSHYHFYEVNDSLAFDRKAAWGKRLDIPSGTAVRFEPGDKKEVNLIDIGGYRRVYGIRNMCDGFLDGMSKGSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KYG5</accession>
    <name>A0A174KYG5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureF_2</name>
        <name evidence="3" type="synonym">ureF</name>
        <name evidence="4" type="ORF">ERS852471_03100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15406">
        <property type="protein sequence ID" value="CUP15406"/>
        <property type="gene ID" value="ERS852471_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP15406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="27629" checksum="0682559A6B918AAD" modified="2016-09-07" version="1">MHMQIDNDILKHLRVIQICDSNFPIGSFNHSYGMETYLRLKKVYDTNTFNSWLDVYLKEQFIYSDGLAIRLLYSFLEKNDMESIYELDRLITVQTVAKESRNGGKLVASRMIKLFMDLYDFDLLKDYNDKLRKKEIFGHPALVFGILMYSLNFNLKEAIIYHMYSTVSTLISNAVRTIPLGQKDGQILLKNYSEEFIHLYEKIMNLDYDDFGANSPGLELSQIKHETMEFRLFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6X3</accession>
    <name>A0A174L6X3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Propanediol utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pduV</name>
        <name evidence="2" type="ORF">ERS852471_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EutP/PduV family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268275.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19962">
        <property type="protein sequence ID" value="CUP19962"/>
        <property type="gene ID" value="ERS852471_03185"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2003468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:cellular biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012381">
        <property type="entry name" value="EutP_PduV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40453">
        <property type="entry name" value="PTHR40453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10662">
        <property type="entry name" value="PduV-EutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036409">
        <property type="entry name" value="EutP_PduV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02528">
        <property type="entry name" value="EutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP19962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16003" checksum="92F402EC8D74ACEC" modified="2016-09-07" version="1">MKKVIFIGKSGCGKTSLCQRLQGEEIRYKKTQSIDLYVDSIDTPGEYLENRNYYSALITTAAEANMIALVQECGDTISMMPPGFAGTFGREVIGIITKTDIGECEDSIDIIEEQLRVAGVRRVFKVSAYSTEGIEELRRYVDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LA80</accession>
    <name>A0A174LA80_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stage V sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">penA_2</name>
        <name evidence="5" type="ORF">ERS852471_03206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268317.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21172">
        <property type="protein sequence ID" value="CUP21172"/>
        <property type="gene ID" value="ERS852471_03206"/>
    </dbReference>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011927">
        <property type="entry name" value="SpoVD_pbp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02214">
        <property type="entry name" value="spoVD_pbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
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        <location>
            <begin position="603"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="665"/>
            <end position="725"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP21172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="729" mass="79673" checksum="C15A83E8865861F7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LEB8</accession>
    <name>A0A174LEB8_9CLOT</name>
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        <submittedName>
            <fullName evidence="9">Capsular polysaccharide biosynthsis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cap8A_5</name>
        <name evidence="9" type="ORF">ERS852471_03196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000031">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20468">
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        <property type="gene ID" value="ERS852471_03196"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP20468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="225" mass="25249" checksum="0F227A2B6F1DB910" modified="2016-09-07" version="1">MEEQVISIEEIFEALKKRWKMIALITILSTVIAGVFSFFIIDPVYEASTKLFVGKEENSTEVYNSNDIAMYQKLLKTYSETIKTRDLLTSAIKDSKYDLEVGAVSSALTVVPVTDTQILQIKYQSKDPKEAEVMLKAISNNFIKTAKELVPNGNVRVIEAVETPKNPVSPNKVMNIAIAFLLGLMVSVGLVFLMEYMDNTYKTKEQLEKELEIPVLGIIPTIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LFM1</accession>
    <name>A0A174LFM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268326.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21337">
        <property type="protein sequence ID" value="CUP21337"/>
        <property type="gene ID" value="ERS852471_03210"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1727241at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018710">
        <property type="entry name" value="DUF2232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09991">
        <property type="entry name" value="DUF2232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="180" mass="20282" checksum="E7B02590D8424080" modified="2016-09-07" version="1">MKSKEITLGGIMVALTSIILYLTSLIPINTLTILTVASAIIPICIIRSDIKTAIFVYIASALIAFFIVPINISMLYAIFFGIYGIIKFFAERNRSKFEALYKIGFFNIAFIVGFILFQNVLGINILKGVEEILSRFINGDIKVITFALFLIVANLAFLVFDYALTLIISFYMERIHKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHG9</accession>
    <name>A0A174LHG9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metI</name>
        <name evidence="7" type="ORF">ERS852471_03215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268346.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21508">
        <property type="protein sequence ID" value="CUP21508"/>
        <property type="gene ID" value="ERS852471_03215"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1464674at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="22496" checksum="4FF4C1505407B127" modified="2016-09-07" version="1">MVNIIIKELGATVYMVFFSTLFATILGFVFGIIAAITSPSGLKPNRIVYKILDTIINVLRSFPFIILIVFIIPLTRAIVGKSIGNTAAIVPLTIAAAPFVARIIESSLKEVDPGVIEAAKSFGASDSQIIFKVMLKEAVPSIISGLTLTIISVIGYSAMAGSVGAGGLGKVAITYGYQGFRTDYMVTTVIILIIIVQSLQSLGNYLYKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJ15</accession>
    <name>A0A174LJ15_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lytC_4</name>
        <name evidence="2" type="ORF">ERS852471_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268336.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21640">
        <property type="protein sequence ID" value="CUP21640"/>
        <property type="gene ID" value="ERS852471_03217"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP21640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="229" mass="25853" checksum="F61B2FE1A85F07D4" modified="2016-09-07" version="1">MAVWILDAGHGGNDTGIVGRALGIKESDIVLEAVLEAKKHLERNGENVVLTRDDDTYLSLEERINIAEKSGGKFFVSFHMNSDIDSSIKGVQVFYTKDNYDSKRLAKLISEEILCDLGTNEKGVLKDESEKYDKFSGIAVIVYGEYLSNNDVEKEFDGKRFGRMIAKACLAMVDKVLLLTPITEPKETQQRAWRVCIGYYRDYNEAIDVMVDMHKKGFKRAHVVPYNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LKQ0</accession>
    <name>A0A174LKQ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268397.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23471">
        <property type="protein sequence ID" value="CUP23471"/>
        <property type="gene ID" value="ERS852471_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP23471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="13046" checksum="6EEF4461A47547CC" modified="2016-09-07" version="1">MWKYLLVGIFLLVVAIIVIVRITTSQKYNIYKKYKRMINFYREKFSNDISNDLVYQYIRDIDGLPKIQNSTEYMDTFIEFYNLINGDNKISDDLKFQLKVSLNLKGIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LPG2</accession>
    <name>A0A174LPG2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <shortName evidence="3">Pol IV</shortName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dinB_3</name>
        <name evidence="3" type="synonym">dinB</name>
        <name evidence="5" type="ORF">ERS852471_03248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268393.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23389">
        <property type="protein sequence ID" value="CUP23389"/>
        <property type="gene ID" value="ERS852471_03248"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="3">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP23389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="40378" checksum="AA8EA75002CA3DFE" modified="2016-09-07" version="1">MDKIILHVDMDAFFASVEQRDNPKLKGKPVIVGGVSERGVVSTCSYEARKYGVKSAMPIFMAQKLCPQGIYLRGRYWRYKEVSAQIFNIFREITPLVEPLSIDEAYLDITNSRFEDYKEAALYIKKRVYKEVGLTLSIGISYNKFLAKLASDWNKPNGIMVITEDMIPEILKPLSISKIYGLGQKSVRRLNNMGMYKIEDLYAHPKEFFIEYFGKYGIDIYNRIRGIDNRAVTPNRDRKSYGKETTLKSDTDDKEELKRYIEDFSLQISNYLQQKNIFIKTVTVKYKTSSFINHTRSKTLLYYINKAEDIYSVATEIIEEEVFSETIRLIGLTVSSIKEEKVEQLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LS94</accession>
    <name>A0A174LS94_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin oxidoreductase, 4Fe-4S cluster-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000042">
        <property type="protein sequence ID" value="CUP27124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268482.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27124">
        <property type="protein sequence ID" value="CUP27124"/>
        <property type="gene ID" value="ERS852471_03306"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1751763at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP27124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="77" mass="8593" checksum="26260F8320174FD9" modified="2016-09-07" version="1">MENKAIFTSVVRVKGNNKYKVVPVKSSEEVDKSLWIEISKVLSRIYVSVPIKLGSIICKNVLNTGIDIVCSRNIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LW20</accession>
    <name>A0A174LW20_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FliB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000039">
        <property type="protein sequence ID" value="CUP26178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26178">
        <property type="protein sequence ID" value="CUP26178"/>
        <property type="gene ID" value="ERS852471_03294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP26178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="34121" checksum="589DF791D93E1EBD" modified="2016-09-07" version="1">MKNNGDEYLSLTCRTFPRIYNEFENITEISLSCSCPEVVEIINNIPGEIDMVTESDIEVTEELLELKIRENIINIINKENISLDKKLIISFQMLLNILDNEEITEDILLNEFKRFEDNKYINEIVSIYKQIDLNKYESIEELNNLFLDIIENYKDVSGLEVLLRDISDYAEEVDLEEVTENWSKFKKKFEEHNRLIKNCIIAKVLSSCISNDVEELALSLQMIIIEYLLVRYAVFLKYSITEGNDINTSDIKDYIVCFSRVIGNNSDSVIEFFEEGFGDPILEIGYLCLISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XK23</accession>
    <name>A0A173XK23_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">[Ni/Fe] hydrogenase, large subunit</fullName>
            <ecNumber evidence="5">1.12.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hupL</name>
        <name evidence="5" type="ORF">ERS852471_00040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.99.6" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50975">
        <property type="protein sequence ID" value="CUN50975"/>
        <property type="gene ID" value="ERS852471_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033748">
        <property type="term" value="F:hydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN50975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="472" mass="52546" checksum="A56C32054BC5E2A7" modified="2016-09-07" version="1">MHNIIVDPVTRVSGLLSIEVQVENNKVVDAKACGNQFRGFEKMFEGRSPLDMIRLTPRICGICSTHHALTSVRALEDAMKINPDENGRIIRDIANGFEFIQNYLRWTYFFVFPDYLEIITVNPLFKTETPKVADYRLDKAITNKINEDYVEAIRLSREAHKGLAVLAGKAPHPHGIWVGGITTNIDIPQIESCRYIITILKDFIINKLIPDVEIIAKAYSDYFKIGGGHGNLMSYGLYDNYAPPIRYSLPKVRINGKEEDLDINNITESVKYTWAVDNGQPLIPGKSNPASPDPTKQGAYSWINAPRYKGFAMEVGALARMTLSGEYKGGISTMDRILAKAYEAKRVCEITEELIKIAKLGKAVQKEWQVPSKALGVGLSEAERGSLAHWISINDKKVENYTVIPPSTWNISPKDDKGVRGTAEEALIGTEIQDITSPVEVGRILRSFDPCLSCAAHVTSDRHKAVTINILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRU7</accession>
    <name>A0A173XRU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262843.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54454">
        <property type="protein sequence ID" value="CUN54454"/>
        <property type="gene ID" value="ERS852471_00107"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2066931at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="124" mass="14708" checksum="FFA71CE0F5FFB17E" modified="2016-09-07" version="1">MDKLLITKIMGKKDAVDLDDSVYNLRDVCDELRNIIILNLPIEDEFKVRNRRRLKAIYDIVKPMTDKLKDDSYIQGYTNSKKYLLKYIEDMTAYIEGILSAMEPLDFKNFTYYTNMLMDLVLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSJ9</accession>
    <name>A0A173XSJ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proline porter II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">proP</name>
        <name evidence="9" type="ORF">ERS852471_00096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53936">
        <property type="protein sequence ID" value="CUN53936"/>
        <property type="gene ID" value="ERS852471_00096"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446363at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN53936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="172" mass="18527" checksum="5AF3DB544418FDFF" modified="2016-09-07" version="1">MYIVNIIFAVAAMPFILWAGKLADKLGKGKLFCMSSIACGLIAIPGMKIIENSGGNLFIITAVIILGWSIFYSGIWGVLGSLWAQLFETEVRYSGISFVYHAPSFLVAGIVPTICTHLLKVGNGNVIFIGIFVAFVAVISTICGVVLQKRHDKAEKLAKMNVKITSEVGVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSQ1</accession>
    <name>A0A173XSQ1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262837.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54310">
        <property type="protein sequence ID" value="CUN54310"/>
        <property type="gene ID" value="ERS852471_00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="71" mass="8410" checksum="1F7A4413289DF783" modified="2016-09-07" version="1">MQVKIEKCEGVNKCWYKSFIGEIFEVEKIEPTGLSKNKIFVKLNKEECRKCFKDKRSYAAVYKNDVKIINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWC2</accession>
    <name>A0A173XWC2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligoendopeptidase</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262889.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55570">
        <property type="protein sequence ID" value="CUN55570"/>
        <property type="gene ID" value="ERS852471_00131"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN55570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="564" mass="66473" checksum="B722A5CD025DDD85" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XYN7</accession>
    <name>A0A173XYN7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carbohydrate uptake ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="8">3.6.3.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ugpC_1</name>
        <name evidence="8" type="ORF">ERS852471_00146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.20" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262914.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56390">
        <property type="protein sequence ID" value="CUN56390"/>
        <property type="gene ID" value="ERS852471_00146"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN56390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="38747" checksum="28717EA3C4006DF5" modified="2016-09-07" version="1">MGIKLENLVVKFGDFKAINDVTLQIPKGKLVSLLGPSGSGKSTTLFTISGIHKPHSGKIFFGDRDVTGLDPEKLGIGLVFQNYALYPHMTVRENIMFPLKNLKWDKAKAEARVLEVAKIVKIQDQLDKKPAQLSGGQQQRVAIARAIAKNPDILLLDEPLSNLDTKLRVETRQEIRRIQKETGVTAIFVTHDQEEAMSISDEIVLMKDGAIQQISSPSDIYMNPCNKFVASFIGSPEMNFIDLTINNGECTIDTLKIDNLPKDMSKGTLGVRAEDFEVATEGLKTKVMTVEILGRERLLTLEHNDRTYKMLVDKEFYINEGEELIVRPKTGKSYVFDAESEAFVTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y398</accession>
    <name>A0A173Y398_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartokinase</fullName>
            <ecNumber evidence="12">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lysC</name>
        <name evidence="16" type="ORF">ERS852471_00167</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262954.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57405">
        <property type="protein sequence ID" value="CUN57405"/>
        <property type="gene ID" value="ERS852471_00167"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="14">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ACT_7" evidence="15">
        <location>
            <begin position="332"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN57405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="398" mass="43050" checksum="0C25FA88F1759F81" modified="2016-09-07" version="1">MEIIVQKFGGTSVSTEERRKQLATKVKAAIDNGMSPVVVVSAMGRKGDPYSTDTLLSLVGKKFMSDNKNAQDLLMSCGEIISSVVVCNTLYNYGIKAVPLTGGQAGILTDDNFTNASFINTDPSKVLELVKNGIVPVVTGFQGITKDGLITTLGRGGSDTSACILGVALKAKEIEIYTDVDGIMTADPRLVDDVSLIDEVTYNEVYQLADQGAKVIHPKAVDLAKKANIPLIIKNTMSDSKGTLIIRDVSEENKRFITGITHLDNRIQVRVRLSENPNHAAYRSLLDSLAKNNISLDLINIFPAHQIFTINADEKEKLNQVLTKANINFTTVEGCSTIAIVGSGMTGVPGVMAKIINTLTENNIEVLQTTDSNITIWCLIYTSKLAQAMNLLHEKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6Y6</accession>
    <name>A0A173Y6Y6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clp protease</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP_1</name>
        <name evidence="2" type="ORF">ERS852471_00210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263033.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59654">
        <property type="protein sequence ID" value="CUN59654"/>
        <property type="gene ID" value="ERS852471_00210"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1399458at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="27628" checksum="CFC533382A34D5A7" modified="2016-09-07" version="1">MNTNEDFYPLYSNDTTIKESDNDKNSKEDDRRQEIKEFGTDNKSSSDQSIQVLPIIGQIEGHMVLPPQTKATKYEHIIPQLIAMERNNEVKGILIVLNTVGGDVEAGLAIAEMIRSLSKPTVSIVIGGGHSIGVPLATSADYSFITPSATMIVHPVRMNGFVIGVAQTFHYFQKMQERIDNFIVKTSKISKDELKRMMLKSDELLNDMGTILIGEQAVACGLIDEVGGIKEALDKLREEIALYEKNNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y875</accession>
    <name>A0A173Y875_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59770">
        <property type="protein sequence ID" value="CUN59770"/>
        <property type="gene ID" value="ERS852471_00212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015991" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="7742" checksum="32CBE03C2E54F616" modified="2016-09-07" version="1">MSSSCSKCCCKKKCCCNNCSSCGCGGCNCGCGYPGYGCCGGGNCGYGGNFGCGGGFGGCGCGGGCWWWLILILLFGCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNF9</accession>
    <name>A0A173YNF9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="3">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">typA</name>
        <name evidence="3" type="synonym">bipA</name>
        <name evidence="5" type="ORF">ERS852471_00275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263173.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65110">
        <property type="protein sequence ID" value="CUN65110"/>
        <property type="gene ID" value="ERS852471_00275"/>
    </dbReference>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN65110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="608" mass="68041" checksum="E57467B3DBD1B543" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWM0</accession>
    <name>A0A173YWM0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation integral membrane protein YlbJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263271.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67967">
        <property type="protein sequence ID" value="CUN67967"/>
        <property type="gene ID" value="ERS852471_00327"/>
    </dbReference>
    <dbReference type="OrthoDB" id="819609at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014226">
        <property type="entry name" value="Spore_IM_YlbJ"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02871">
        <property type="entry name" value="spore_ylbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="43495" checksum="4162F18948874D54" modified="2016-09-07" version="1">MHSIIFLWLSIFILIFVLLKLLNINKNYFVSFLISFCIILFVLNLKDCINASLVGLNLVIKTILPTIFPFSFICNLLICYDGISLYSKILGPLLCRPLKLSKNSSFPIAASVLCGYPLGCKYCCDLYNLGYINKKEFERLLNIASNASPMFLIGSVGATMFGNTKLGFILLIANYLSPLIIGIITIPKGDFNKNSKVMHSEFKKVSIGSALKTSIENSVNTTLQVGAFVIIFSIIISIIKSNAYISITFKNIEDFLNIPSSSLYGTLLGSIEFTNGCKLISSSTLPLILKLSIISFICSFSGLSVIAQISSFIGDLNISLFKYSFLKFIQGIISFIITFIACIFFVKDTPVSTFPIQTFYIDNKILLIIYCILILSLICTFIRYKKNLHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZB7</accession>
    <name>A0A173YZB7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimM</name>
        <name evidence="6" type="ORF">ERS852471_00344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263295.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68869">
        <property type="protein sequence ID" value="CUN68869"/>
        <property type="gene ID" value="ERS852471_00344"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN68869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="165" mass="19340" checksum="62C4FAFF3F786A35" modified="2016-09-07" version="1">MSEVLKVGKIVNTHGLKGEVKVMALTDDQRRFDDLDYVLIDNKEVKIESCKYQKDRVIVKLEGVNKVEEAEKLKNKFMEIPREFAVELDEDCYFLADLRECTVFDTDGKEIGEVYDIIQTKNNDVYWIRKPKEVLIPALKDIVTEINIDDRRIIIRPIGEWMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0A7</accession>
    <name>A0A173Z0A7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RIP metalloprotease RasP</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rasP</name>
        <name evidence="11" type="ORF">ERS852471_00361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263328.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69901">
        <property type="protein sequence ID" value="CUN69901"/>
        <property type="gene ID" value="ERS852471_00361"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN69901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="339" mass="37226" checksum="17B0B03924B50241" modified="2016-09-07" version="1">MYIIAAILGFSLLIIVHELGHFIMAKVNGIKVEEFSIGMGPEIFSHKGKETQYSLRLFPIGGYVKMLGEEEVVDDERSFSSKSPLRRISVIIAGAIMNILFALVIFTVFFFNRGFSTQTVSKVVENSPALESGLQAGDTILKINGSRVFTPSDVSIEIQLSKGDNVNLLVDRNGEKVDLSITPRLVEENGSQIYQIGFYYSAVENPTIGQAIKATFNETISLVGQTYKSLKLLVTGKLNFKTDVGGPVTIIKISGQAAKNGLYTLAYFLAFISINLAVFNLLPFPALDGGWTVILLIELITRRKVPDKIVGAVNYVGFMILIGFMIIVTLKDIIFPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z549</accession>
    <name>A0A173Z549_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="13">ACCase subunit beta</shortName>
            <shortName evidence="13">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="13">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">accD</name>
        <name evidence="15" type="ORF">ERS852471_00380</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="13"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263364.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70913">
        <property type="protein sequence ID" value="CUN70913"/>
        <property type="gene ID" value="ERS852471_00380"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504557at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041010">
        <property type="entry name" value="Znf-ACC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17848">
        <property type="entry name" value="zf-ACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN70913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="31474" checksum="EACC36F10091AF28" modified="2016-09-07" version="1">MGIFKKRQYGVVNLTKEEALDLPIVPDGTWVKCGNCGKILYKKVLEENYKICNHCGGYFRLGAYERIDQICDKGSFNGFNSSISSRNPMNFDGYEKKLKSNREKSGLIEAVITGDCKINGIKNIIAVMDSNFLMGSMGIAVGEKITLAIEKATKEKLPIIIFTTSGGARMQEGIFSLMQMAKVSSAIAKHNDEGLLYITVLTDPTTGGVTASFAMLGDIILAEPKALVGFAGRRVIEGTLKEKLPDDFQSAEFLLENGFVDKIVKREDMKRTLYKLLKLHGYKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6Y0</accession>
    <name>A0A173Z6Y0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF1_1</name>
        <name evidence="9" type="ORF">ERS852471_00392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263383.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71543">
        <property type="protein sequence ID" value="CUN71543"/>
        <property type="gene ID" value="ERS852471_00392"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09607">
        <property type="entry name" value="M3B_PepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034006">
        <property type="entry name" value="M3B_PepF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="195"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN71543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="592" mass="68378" checksum="7A3DAD2429FF5CD0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAR2</accession>
    <name>A0A173ZAR2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rnfE</name>
        <name evidence="8" type="ORF">ERS852471_00423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263435.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73037">
        <property type="protein sequence ID" value="CUN73037"/>
        <property type="gene ID" value="ERS852471_00423"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1782047at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN73037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="224" mass="23612" checksum="85E63E5895BFED91" modified="2016-09-07" version="1">MKEKVSNLSILTKGIIKENPVLVLLLGTCPTLAVTSMAMNGLGMGLATTFVLIGSNIVISLLKNFIPKEVRLPSFIVIIAGFVTVVGFLMQSYLPSLYKSLGVFLSLITVNCIILARAEMFACKNKVFASILDAIGMGIGFTLALFAIGSIREILGSGTWMGITLTKDIIEPMGIFVTPAGGFFVFGCLIALVNKLTNYSISKKKAGCSACPGKDACHGSEGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZC86</accession>
    <name>A0A173ZC86_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phoR_2</name>
        <name evidence="8" type="ORF">ERS852471_00428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205628.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73280">
        <property type="protein sequence ID" value="CUN73280"/>
        <property type="gene ID" value="ERS852471_00428"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="232"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN73280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="482" mass="55609" checksum="CC67BFF4F107B3C2" modified="2016-09-07" version="1">MTTKRKKCFISAETYFENINEYHQFERLRIETNMNKMNLPFLLLIFLNIILILVDIFYYKAISKDNLSYYYLYLAHVSMIIVSIIWVIYYKIISKKLSYKTNKAIYAVFADCVIWWGIFMSLDLFQSTNQISSYIIIMFCYATLIYIPLIVSVIKTVIPALTMLTYIILFAKDTTSMMDNIVNIVFTVIFSILISNLMYKHFLSEFIKDIKVKKANKKIEEAEKIRTEFFANVSHELKTPLNIIYTAQQMIEVTTKNDNYRNENFIKYMQMSKQNTNRLHRLISNLIDITKIDSASFKIKEINVDIVKIVEDITLSAACYIESQGMSLTFDTDVEELVIACDPDSIERIILNLLSNAIKFTERGGDIFVDIKSTMKEVLISVKDTGIGIPKEMKEKIFERFAQVDKSTYRKKEGSGIGLSLVKSLVELQGGSINIDSEINKGSTFTVKLPIARVEESENILPQSAVDANIEKIKVEFSDIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCF2</accession>
    <name>A0A173ZCF2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase family protein</fullName>
            <ecNumber evidence="1">1.3.8.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crtN_2</name>
        <name evidence="1" type="ORF">ERS852471_00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.8.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263466.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73924">
        <property type="protein sequence ID" value="CUN73924"/>
        <property type="gene ID" value="ERS852471_00440"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102223">
        <property type="term" value="F:4,4'-diapophytoene desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="112" mass="13138" checksum="57EF51C481DD35B8" modified="2016-09-07" version="1">MKKVFIIGAGIGGLSVAARLLQYGFEVEIFEKNNTIGGKTNFIEFKDFKFDLTASIMMFPENYIDLFKFCNVDYKNYFSMIPLYNLYSVFYYDNSKYNFSTNLPNLNRLCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJF6</accession>
    <name>A0A173ZJF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">panT</name>
        <name evidence="2" type="ORF">ERS852471_00467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75368">
        <property type="protein sequence ID" value="CUN75368"/>
        <property type="gene ID" value="ERS852471_00467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="21186" checksum="6C9EC096262D8A1F" modified="2016-09-07" version="1">MLKTSGMGRSQTKIRKLVIIAMLSSISIFLGVSGLGFIRLPAFSLTIMHLPVIIGAILEGPIVGASVGLMFGLFSMYQALTAPNVTSFLFLNPLIALVPRILIGLVAYYVYRFLVKTLKKPKISIGISAILATFTNTVGVLGLTYILYLEEYAKAINISPNVVGATLFGVATSNGLLEAIASALIAVPVVMGVLKIKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZU52</accession>
    <name>A0A173ZU52_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfite reductase, assimilatory-type</fullName>
            <ecNumber evidence="5">1.8.-.-</ecNumber>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sir_1</name>
        <name evidence="5" type="ORF">ERS852471_00506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.-.-" evidence="5"/>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79821">
        <property type="protein sequence ID" value="CUN79821"/>
        <property type="gene ID" value="ERS852471_00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017220">
        <property type="entry name" value="Sulphite_reductase_assimil"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037487">
        <property type="entry name" value="Sulfite_red_assimil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="85"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN79821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="23416" checksum="81CFC0922AB7081B" modified="2016-09-07" version="1">MKDLLDKGAVIQRDKESYAIAPHLTGGLVTPEQLRKIADVAEKYNAAALKVTGAQRIAIVGIKEEDIDKAWNDLGMKPGAAIGLCVRSVKICPGTTFCKKGMQDSVAIGAKLDGAYHGRNLPNKLKIGVSGCVNSCSDSHTRDIGLIGTAKGWMVLVGGKGGIKPRLGDRILINVSNDDIFGVVEKIINVYGDNALGKERLGDYIDRVGLDEFKAKLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A184</accession>
    <name>A0A174A184_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">graR_2</name>
        <name evidence="11" type="ORF">ERS852471_00536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263657.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82341">
        <property type="protein sequence ID" value="CUN82341"/>
        <property type="gene ID" value="ERS852471_00536"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="26087" checksum="C161A87634247D5B" modified="2016-09-07" version="1">MSNKIFIVEDEDKIREELITLLNRYGYETEFSNDFKNIVEDILKAIPSLVLLDINLPYYDGYYICREIRKKSNLPIIVVTSRDSEIDELMSMNLGADDFVTKPYNTQILLARISSLLRRSYSKNESEVYQFKNLKYNLSTSEAEYEGSTIELTKNESRILYTLIKNKEKIVSRDDIMKSLWQSNEFVDDNTLTVNINRLRKKLEEIGAEGYLQTKRGQGYILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIB4</accession>
    <name>A0A174AIB4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase, Fe-dependent alcohol dehydrogenase family</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bdhA</name>
        <name evidence="4" type="ORF">ERS852471_00612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263799.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87953">
        <property type="protein sequence ID" value="CUN87953"/>
        <property type="gene ID" value="ERS852471_00612"/>
    </dbReference>
    <dbReference type="OrthoDB" id="717704at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN87953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="386" mass="42619" checksum="4F406309B2291A91" modified="2016-09-07" version="1">MDNFRFGAPTEMLFGKGQISNLPEVLKRYGRNVLLAYGGGSIKKNGIYDKVQELLKDFNIVELSGIEPNPRIETVRRGIDLCRENNIDVILAVGGGSTIDCSKVVAAGYYYEGDTWDIVLDSSKITNALPIVTVLTLAATGSEMNKGAVISKMDTNEKLGTGAICMAPKTSILDPEYLYTLPAIQTAAGTADIMSHVFENYFKKTKDAYVQDKMSEGLLETCIKYCPIALKDPTNYEARANLMWASSMALNGLTGSGKVGAWSCHPMEHELSAHYDITHGVGLAILTPSWMRYILNDETVDKFVDYAINVWHLPYNEDKFALANEAIDATENFFKECGIPMTLREVGIDDSKFKEMAAAAVKHGNLQYAYVPLDQEDVYKIFGMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKJ5</accession>
    <name>A0A174AKJ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
            <ecNumber evidence="2">3.1.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">exoX</name>
        <name evidence="2" type="ORF">ERS852471_00616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.11.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263806.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88180">
        <property type="protein sequence ID" value="CUN88180"/>
        <property type="gene ID" value="ERS852471_00616"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="215"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="306" mass="34802" checksum="D0BF7988C0BCEA37" modified="2016-09-07" version="1">MDFVAIDFETANEKRNSPCSIGIVIVKGGQVVEKIHYLIKPKEMRFMPINIGIHGIRPAMVKDEPEFNEIWDKIKHYFNEDNLIIAHNASFDVSVLRNTLELYNIEAPKFNYICTMKLARNFYKQLDNAKLNTVNKFLGYEFNHHDALADALACSNILLNISEELETKDIMEISKFIGVTLGTVNKDGYTPSFTKGRVLRTSGKIFSREIKNDNYNFDAFKDEVIVFTGGLGSMSREEASRLVRKLGGSIGSSVTKKTTILITNTKDIESLQREEMSIKLRKAVDLRAKGQNIIIMNEDEFLLKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALK8</accession>
    <name>A0A174ALK8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263842.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89287">
        <property type="protein sequence ID" value="CUN89287"/>
        <property type="gene ID" value="ERS852471_00636"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="19365" checksum="6061F1B621252AB7" modified="2016-09-07" version="1">MVEMNIRELYEVGTTFESAVGQGTKSERARIPKNYSRINFTEDMVNFLASFDKEINFLIAGEIWCPDFQLNATVLKKFTEINSNFDMSVISMGRGKKFLFPILNVENMKFPVIVVLDKEFNILGTFEERPNVVHESSNFEDIKLDYYKGRYLIDSANEFIDIMNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5T6</accession>
    <name>A0A174B5T6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
            <ecNumber evidence="2">3.5.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yabJ</name>
        <name evidence="2" type="ORF">ERS852471_00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263995.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96094">
        <property type="protein sequence ID" value="CUN96094"/>
        <property type="gene ID" value="ERS852471_00714"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="126" mass="13957" checksum="C872F8035D532929" modified="2016-09-07" version="1">MKREVINSVKAPDAIGPYSHCNKVGNFIFTSGQLPLDKETKELKTDIKEATRQSLENVKSILEEAGSSIRNVVKATVFVKDLTQFAELNEVYNEYFGENPPARSCVQVAKLPMDAVVEIEVIAIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBJ5</accession>
    <name>A0A174BBJ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gdh</name>
        <name evidence="10" type="ORF">ERS852471_00758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264077.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98391">
        <property type="protein sequence ID" value="CUN98391"/>
        <property type="gene ID" value="ERS852471_00758"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="205"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN98391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="448" mass="48702" checksum="814567F14902D240" modified="2016-09-07" version="1">MNGREYVLKVLDEVSNRNAGEKEFLDAVKEVLLSLSPVFDKHPEYIEAGLLERIVEPERQIMFRVPWVDDNGNVRVNRGFRVQFNSAIGPYKGGLRFHPTVNASIIKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGKSNGEVMRFCQSFMAELYRHIGQDTDVPAGDIGVGAREIGYMYGYYKKLRGANDPGVLTGKGLTYGGSLTRTEATGYGLIYFTEEMMKDNNLSLAGKTVVISGSGNVAIYATKKATELGAKVVALSDSNGYIYDENGINLDAVKEIKEVKRGRIKDYLNYVPTAKYAEGCRGIWNIKCDVALPCATQGEIDEASAKILVSNGTRVVAEGANMPSSLDAIKVFQENGILFGPAKAANAGGVACSALEMSQNSMRLSWTFEEVDNKLKDIMVNIYRQSAEAAKEYGEEGNILMGSNIAGFNKVAEAMMAQGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFQ2</accession>
    <name>A0A174BFQ2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gyrA_1</name>
        <name evidence="9" type="ORF">ERS852471_00760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264081.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98555">
        <property type="protein sequence ID" value="CUN98555"/>
        <property type="gene ID" value="ERS852471_00760"/>
    </dbReference>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="17"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN98555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="972" mass="109794" checksum="FB53CF5679D04BB1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6T6</accession>
    <name>A0A174C6T6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">gpmI</name>
        <name evidence="14" type="ORF">ERS852471_00935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264433.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09172">
        <property type="protein sequence ID" value="CUO09172"/>
        <property type="gene ID" value="ERS852471_00935"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338375at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="4"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="82"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO09172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="512" mass="56453" checksum="4BFB88029B64BD4A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C729</accession>
    <name>A0A174C729_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pepV_2</name>
        <name evidence="4" type="ORF">ERS852471_00908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.13.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264379.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07710">
        <property type="protein sequence ID" value="CUO07710"/>
        <property type="gene ID" value="ERS852471_00908"/>
    </dbReference>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="41843" checksum="4E6C9EFE50319884" modified="2016-09-07" version="1">MENILNIKIDENKDKMINHIIDVVKIPSVESEAVDGAPFGEEVNNALLKALEISEELGFKTKNIDGYMGYAEFGEGEDYVGVFGHLDVVPEGEGWINPPYSGHIEDGKIFSRGVLDNKGPIMSALYGLYAIKESGLKLTKPVRIVFGTDEESGFEDLNYYLSKEKPPVMGFTPDCKYPVVYGERGRAKIRVKVDIDNENRVQRTREFFDFVNKYILSSKDNGERLGINYDDKEFGTMVMRGYSLDNDENSLGFNLALSYPAVATIDEIMKQIRSKATENVEIELLHNYNPVKFEKDCFLVKSLQDAYEDITGLDGTPVTTTGGTYAKAMPNIVPFGPSFPGQKGIAHNPNEYMDISDIILNAKIYAQALYRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFI3</accession>
    <name>A0A174CFI3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MgtE integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264481.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10488">
        <property type="protein sequence ID" value="CUO10488"/>
        <property type="gene ID" value="ERS852471_00962"/>
    </dbReference>
    <dbReference type="OrthoDB" id="663062at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="293"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO10488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="418" mass="48311" checksum="92A4AC9B2207B1A4" modified="2016-09-07" version="1">MKKLSVLLFSSILDKKIYDEFDEVLGTLKDIYVTTDEGYPRVIGYKVKRDRSTFHYEFRSVIFLQNDNKVKIMTRGSKEILPRRYSYLLSEHLLDKKIVDINGKQVVRVDDLRIAEIAGEYRVIAVETGPMARARRFGLLNVGKLIYKTLHKDFEDKVLMWDDVESLEMVNNNLQIAIPYKKLSTLHPADLADILEDLDSNSRKKIFEFIDEDLAADALEEIDPEYKGAIIKDISEAKAAELLENMPNDEIADFLDELDDDEREKILINLEAEDANEVKELLQYDDETVGSIMSKEFISFNIDITIGEIIEILRETEPEDEQLNSIFITDEDERVLGILTLKDLIMNTPETKAREAMNENTNVIRHFVDINEAIEIVSKYDLLSIPVVDDNDVLIGSVNTHDLIDEFLYPMWKKKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGL6</accession>
    <name>A0A174CGL6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein of uncharacterized function (DUF421)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yetF</name>
        <name evidence="10" type="ORF">ERS852471_00999</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12333">
        <property type="protein sequence ID" value="CUO12333"/>
        <property type="gene ID" value="ERS852471_00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="279" mass="31001" checksum="93DB98BDFC8F1571" modified="2016-09-07" version="1">MFIVLIRTIFLYALVILVMRLMGKRQIGELQPYEFVITIMISDLAALPMQDTRLPLILGIIPIVTLLFIKTVLTQLQLKSQAARKFLEGEPSILICKGKINFKALKSQQINLDELMEELRLAGYFDLNEIEYGILENNGQMSFLTYDASSESSSSKENQSQSSSSSGDSSQNSSSKTNSSSSPPANSGTSTINIQGSNSPNKTTSSSSNQRPRLPVIYVLDGHVNKNSLTTSGKNKYWIEAELKKHGINSIKDVLLYMTDTNGKIICQLYDDYEKGCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CK75</accession>
    <name>A0A174CK75_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent phosphoesterase, PHP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264527.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11966">
        <property type="protein sequence ID" value="CUO11966"/>
        <property type="gene ID" value="ERS852471_00993"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="32249" checksum="397CDB013FC3921F" modified="2016-09-07" version="1">MLVDLHTHSYYSDGTMSPREIIEEAKRKNIEVIAITDHDEIGSYKEAKEAADELGVTLIRGVELDCKFEDIVVHVTCYKFDNNDEMITLVDKAQNALLETSFELIRRMEKDYEDISYDEFTRYKHDKRKGGWDGIHYLYDKKITEGLFDGMKYYREYNCGHEHFDFPTVEEACSVVHKAGGYAVLAHPCNYYKEKSKEEIIEKLNKFKSMGIDGIESYYPANSELMTETCIEFCKDNDMIITCGSDGHGDFAAVSKGVEYYIGAMKVDSEKLLNIEKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D021</accession>
    <name>A0A174D021_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18647">
        <property type="protein sequence ID" value="CUO18647"/>
        <property type="gene ID" value="ERS852471_01095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="96" mass="11085" checksum="8361D3E628578841" modified="2016-09-07" version="1">MNTLPSAIHYIKIMFGFGNNIFIDTMAKYILSNNFIILTLGLICSTKLIRNYINKIKYTLKEKDVFLIASMNLIILIISTAYLVGASYNPFLYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8P7</accession>
    <name>A0A174D8P7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="3">2.7.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiD</name>
        <name evidence="3" type="ORF">ERS852471_01156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264671.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21587">
        <property type="protein sequence ID" value="CUO21587"/>
        <property type="gene ID" value="ERS852471_01156"/>
    </dbReference>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="29141" checksum="B24352023191293D" modified="2016-09-07" version="1">MRNYKIPTLTIAGSDSSGGAGVQADLKTFSAIGTYGMSVITAITAQNTQGVFLVEDLSEEVIRKQIEVVFEDIEPAAVKIGMVSSPVIISSIVETLKRYNPKYLVVDPVMISKSGYYLLKPEAKKSLIEELIPMAYIITPNTLEAEEISGMNIETVDDMREVGEKILELGPKYVLMKGGHLEGDAVDVLIGKDTFEIFKQERLDRKNTHGTGCTLSSAITSHLALGYDIKEAVRLSKEYITEAIRHSFDIGKGVGPVNHFYKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9M2</accession>
    <name>A0A174D9M2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264682.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22183">
        <property type="protein sequence ID" value="CUO22183"/>
        <property type="gene ID" value="ERS852471_01168"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1255662at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="98"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO22183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="551" mass="61359" checksum="5A3E3813AD7B50BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAA4</accession>
    <name>A0A174DAA4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264691.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22561">
        <property type="protein sequence ID" value="CUO22561"/>
        <property type="gene ID" value="ERS852471_01177"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2124324at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019868" evidence="1">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="262" mass="30154" checksum="7B5D38E9B38F9A38" modified="2016-09-07" version="1">MKKLVFILFIIPMIMIGCVASGEKDNNEITEVKFKDMIDIKELEKLDGKKIKMVGFFAQSSPLDGSMAYLMNMPYQNCAYCLPNTNQLMNTMAVYPKKGKQIEFTDLPVEIIGTIKFENITDQMGYSYNYRIVDAEISLADVDSMSDDVKIYTDLVDRGFPDKISNIILLINNIQSIRVEGENLESVELIPDELVEEVYELFNGLDKDKYIDVLAIVDEVKILVDKVNNSLITKDYDSMDEYIDNEVEIFYKVYEWLMKPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DD11</accession>
    <name>A0A174DD11_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anhydromuramoyl-peptide exo-beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybbD</name>
        <name evidence="4" type="ORF">ERS852471_01195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264706.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23374">
        <property type="protein sequence ID" value="CUO23374"/>
        <property type="gene ID" value="ERS852471_01195"/>
    </dbReference>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019927" evidence="2">
        <location>
            <begin position="26"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="56"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO23374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="405" mass="44819" checksum="292D57A3C4728826" modified="2016-09-07" version="1">MRSIKIFMISAFMILLMAGCGGDSIKEESSNEYNTEKHTEETKELDKIKEKINSMTLEQKIGQLFIVGFEGDIINDEIIDLVKNQEVGGLIYFSRNVLDSNQIITLNNEIKAIKKDIPLFISVDEEGGVVSRVPDEFLKLPSSGYIGKFDDENLSYNIGSIISKELKSLGFNMDFAPVLDIDSNPNNTVIGERAFGNNADIVSKLGIKTMEGLRDGGIIPVVKHFPGHGDTDIDSHYGLPIVTKTLEELNNLEFIPFKNAIENGADVVMVSSIILSSIDSEYPATMSKKVTTDILRNKLNFDGVIATDDMTMGAIMDNYNLTDAVIMAINAGNDLILVCHGYDDIIKSISAVKDAVSSNIISEERIDESVYRILKLKEKYRVNDDIISNEIDIEGINLEINSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEE5</accession>
    <name>A0A174DEE5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonyl/alanyl tRNA synthetase</fullName>
            <ecNumber evidence="4">6.1.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">alaS_2</name>
        <name evidence="4" type="ORF">ERS852471_01180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264693.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22689">
        <property type="protein sequence ID" value="CUO22689"/>
        <property type="gene ID" value="ERS852471_01180"/>
    </dbReference>
    <dbReference type="OrthoDB" id="783542at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_SAD" evidence="3">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO22689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="399" mass="45275" checksum="B55DECC7DC1D7B83" modified="2016-09-07" version="1">MEKLYYLDRYIKEFTAEVVEVKEIDGMYHVALDKSAFFPGGGGQPGDTGFIESSKVIDVYEDNGVVYHVLEKKPLKIHRVKCKIDWEKRYDGMQQHLGQHVLSGCFYSLFNANTVSFHMGSESSTVDIEGFLEEDKIREAERFANEIINQNIEVEFFTPSKSELKKIKIRRALPKTDDAITIVKIGDLDINACCGVHPKSTLDLRMIKIKRWEKHKGATRIEFLAGKRAIDDSLRRDSIIATICKSMKCGESEILNIISKSAEEIREYQNENRMLKLELSKYEIKEMIESADKIGDISIIKKIYEKSDLKHIGKLAEKLVENKKTIALFAVKYDDKSNLIFASSKDNDISMNELLKDAITLIDGRGGGSKFLAQGGGKKSNNLEATIDYAFMKIKNSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKL5</accession>
    <name>A0A174DKL5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264740.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25984">
        <property type="protein sequence ID" value="CUO25984"/>
        <property type="gene ID" value="ERS852471_01221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="77" mass="9208" checksum="64C891C0BF2AD55B" modified="2016-09-07" version="1">MEKNYEKFLLDENLINCEKLLEKVILELQEVKDILKKIECMKEKINLETLDDKQTLEIREIELTKSNVIEVNVEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNT9</accession>
    <name>A0A174DNT9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase</fullName>
            <ecNumber evidence="4">4.2.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">slt</name>
        <name evidence="4" type="ORF">ERS852471_01248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264781.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27271">
        <property type="protein sequence ID" value="CUO27271"/>
        <property type="gene ID" value="ERS852471_01248"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO27271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="21440" checksum="2F1C17BDEBE003FD" modified="2016-09-07" version="1">MDYKKLLVVVLVAVTMFFITRCGVKNFFFPYKYKEYVDKYSVEYGVDPLLVLSVIKGESNFEPKAESNRGAKGLMQIMDSTGEWVAEEIGVEDFTPDMLFDEEINIRFGCWYLKNLEGEFGSLDLILAAYNAGSGHVTKWLKDERYSPDGDVLTYIPFAETKKYVDKVKINYNVYKYFYRKNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQZ6</accession>
    <name>A0A174DQZ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264813.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28012">
        <property type="protein sequence ID" value="CUO28012"/>
        <property type="gene ID" value="ERS852471_01265"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020174" evidence="1">
        <location>
            <begin position="29"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO28012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="345" mass="37631" checksum="C212C6D1C3B63087" modified="2016-09-07" version="1">MKKGLKKAIAFIASSVLVISALVGCSSNTTKDNGGETTNELKTVRLNEVVRSVFYAPMYIAINEGFFEEEGLSIDLSTGQGADKTMQQLLSGSVDIGFSGPEQVVYIYNQGREDYPVVFAQLTQKDGSFLVGREEEENFDWTSLKGKELIGGRPGGIPEMALEYVLKENGLDPTKDVSMVTNIDFTATSGAFKSGTGEYVALFEPTASMLEKEGSGHIVASVGESAGNIAYTCFYTTKSYMDENPEIIQSFTNAIYKGQQWFATHSDEEVADAIISFFPGTDKDIIINVVSNYREIDALASTPEVSEEGLNKLIDIIQGYDSSLITERPDFNTIVNNTFAKEAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTV6</accession>
    <name>A0A174DTV6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264847.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28884">
        <property type="protein sequence ID" value="CUO28884"/>
        <property type="gene ID" value="ERS852471_01283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027365">
        <property type="entry name" value="GNAT_acetyltra_YdfB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12746">
        <property type="entry name" value="GNAT_acetyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="266" mass="31060" checksum="8435432973CC82C6" modified="2016-09-07" version="1">MLRLASEKDRKEVLDYCLGEPNINLFIIGDIENFGFDKEFQNVWIQYDEEIIRGIVLRYHTNFIVYSRNLDMNFKEIAELLVEKDAKVVSGKLSVINKIYELIENSYNKREMFFCELRDESKLEEVKEENIVIATSSDSMEIAKAYEKIEEFKGMYSDDLNERYNQINNRILSKEGIHIFIKEDNEIIAHGNTTATTSVNAMIGGVFTVQNHRNKGLASKIVSYLAKRLINEDKSACLFFDNEEAGRIYHRLGFENIDKWCMLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVH8</accession>
    <name>A0A174DVH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M28</fullName>
            <ecNumber evidence="3">3.4.11.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywaD_1</name>
        <name evidence="3" type="ORF">ERS852471_01298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264873.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29582">
        <property type="protein sequence ID" value="CUO29582"/>
        <property type="gene ID" value="ERS852471_01298"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020273" evidence="1">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="117"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO29582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="329" mass="36703" checksum="9D4FB829EF1476EC" modified="2016-09-07" version="1">MKTLNRLLSILLIFSLVSCGDKAASTRPDATSDTLLEQTSDWSNFQYKIDTDGHVEKIMNDLCSEAYLGRVVGTKENERAQEYIKDYFKNLNISPFDNNYYISNKDGVISLSENTNNVAAVIKGTDSSKAVYITAHLDHVNDANNNPLNGAIDNASGIAVLLETAHKVKELTDKTPLDMDVVFVAFNAEELGLLGSQNFFNKYYKTYSESYNINIDCVAQKNCNTLSMGNDDPNSEELYKAMKEIFDKENVIYDDSLYATKNGVRYGTSDHIVIRQYGAPSLVLGDSTIMDVVHTNKDNLENIDYSDLEKLSDALSKFLMANNGNTFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0Y5</accession>
    <name>A0A174E0Y5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative kinase involved in propanediol utilization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264895.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30146">
        <property type="protein sequence ID" value="CUO30146"/>
        <property type="gene ID" value="ERS852471_01310"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1240505at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012363">
        <property type="entry name" value="PduX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF1">
        <property type="entry name" value="PTHR43527:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033887">
        <property type="entry name" value="PduX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="3">
        <location>
            <begin position="184"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO30146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="31256" checksum="D51894AF8C18B18D" modified="2016-09-07" version="1">MKIIERYPGSVGEVIQGKCNEIDILLSCPINLYTKIVLSDEVERENESFYLKSYKFIDNILEEWGYKGKKVGVAINSTIPKGKGFASSTADLCAIYNGLLKLTDRSFNEEELIRHCLKIEPTDSIIFDKATIFDYKEGAVKEKVGSYFKFYVLCFIGKNIVDTVEYNGKKLEPLKDINDLLIDLREAFENRDTKKLAKVSTESIIRNQHRLKYDILEEILEIKKLTGGLGIIGAHSGDMLGIIFDSIDDEKMKEIEKSEIIGYEKIIVETLDAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E232</accession>
    <name>A0A174E232_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yeiL</name>
        <name evidence="3" type="ORF">ERS852471_01346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264957.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31507">
        <property type="protein sequence ID" value="CUO31507"/>
        <property type="gene ID" value="ERS852471_01346"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO31507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="226" mass="25982" checksum="8070E26AA1422D1F" modified="2016-09-07" version="1">MKEIINAEILKHYINEYSLAKYLNKNLINSCKIYTFEKNEFICTLNEKLEYMYFLVKGKAKVTTLLSSGQSLLLCFNNPLSIIGDLELLDNPYADCNVITLENCICLAIPIWSIHNHGYNDPLFLRFIISSLENKLRNNSIYSSINILYPLENRFASYLLSVLPSNSTSLTIEGVNHISELLGSSYRHLNRVIKTLVDSHVIKKNKNEIQVLNLKKLESLAKDIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGE8</accession>
    <name>A0A174EGE8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease M5</fullName>
            <ecNumber evidence="9">3.1.26.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNase M5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA terminal maturase M5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnmV</name>
        <name evidence="11" type="ORF">ERS852471_01431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ribonuclease M5 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265107.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36357">
        <property type="protein sequence ID" value="CUO36357"/>
        <property type="gene ID" value="ERS852471_01431"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630928at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043822">
        <property type="term" value="F:ribonuclease M5 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01027">
        <property type="entry name" value="TOPRIM_RNase_M5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01469">
        <property type="entry name" value="RNase_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004466">
        <property type="entry name" value="RNase_M5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025156">
        <property type="entry name" value="RNase_M5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034141">
        <property type="entry name" value="TOPRIM_RNase_M5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13331">
        <property type="entry name" value="DUF4093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00334">
        <property type="entry name" value="5S_RNA_mat_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO36357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="20375" checksum="5D4E1283986A30FB" modified="2016-09-07" version="1">MIKEVIVVEGRDDITAVKQAVDAEMIAVGGFGINAKVIARIKEAQKRKGVIVLTDPDFAGEKIRKIIAKRVPGIKHAYIAQEDGIKGDDIGVENATPEVIIEALNRAKVTLEVKEKVFDYEDMIYFKLTGDSNSKARRIELGKELGIGYGNANQMLSRLNNYGITKEEFINAINKIDKKLEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQH9</accession>
    <name>A0A174EQH9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppiA</name>
        <name evidence="7" type="ORF">ERS852471_01473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265180.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38220">
        <property type="protein sequence ID" value="CUO38220"/>
        <property type="gene ID" value="ERS852471_01473"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO38220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="18979" checksum="622F4EFB6DE9E8C1" modified="2016-09-07" version="1">MKNPIVTFEMENGGVIKAELYPEVAPNTVKNFVDLINRGFYDGLIFHRVIPGFMIQGGCPEGMGIGGPGYSIKGEFSRNGFKNDLKHTRGVLSMARAMSPDSAGSQFFIMVADAPHLDGQYASFGKVIEGMDVADKIVATKTDYNDKPYEDQVIKKVTVDTFGEKFDEPAIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2H0</accession>
    <name>A0A174F2H0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD_1</name>
        <name evidence="4" type="ORF">ERS852471_01536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265302.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42385">
        <property type="protein sequence ID" value="CUO42385"/>
        <property type="gene ID" value="ERS852471_01536"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO42385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="32963" checksum="B946831F6C62DF95" modified="2016-09-07" version="1">MKILITGSNGQLGNELQKIISTGRAEIGEISNEIKTSEVFALDVDRLDITSLQQVRTVLLEIKPDVVINCAAATNVDGCETNQDLAFRINAIGARNLAMVAEEIGAKLVQVSTDYVFSGIGDKALTEFDLTSPYSVYGKTKLLGEEYVRELCSKYYIVRTAWLYGYVGHNFVYTMMRLGKEKKSLNVVNDQKGNPTNANDLAYHILKLIETEEYGIYHCTGKGECTWYDFATEIMKLSGRECIVNPCTSEEYKTLAKRPEYSSLDNMMLRCTIGDEMREWKEALKSFIDNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F324</accession>
    <name>A0A174F324_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell envelope-related function transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lytR_2</name>
        <name evidence="4" type="ORF">ERS852471_01576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265383.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44464">
        <property type="protein sequence ID" value="CUO44464"/>
        <property type="gene ID" value="ERS852471_01576"/>
    </dbReference>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="86"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="312" mass="34453" checksum="ECD6C12035891C9B" modified="2016-09-07" version="1">MREKHSKKKKMNPWVKGSLIIVSILVCIFLIGAFTVYRTLGKMQQVSVDTSDLSINYEEIQEFENHEEIINIALFGIDSEDGVAGRSDAIMVATIDPVHNKLKLTSIMRDSYVNIPDIGMDKINHAYAFGGPQLAIKTINENFGLDITDYMSVNFTSLPIIIDILGGVEINITDEEVSHIPGINSAGTYNLTGDQALSYSRIRYATGGDYVRTERQRTVLNALFNKASTLSVTALPGLLNEVLPHVQTSMNASDILSLGTKALGSVSNGLAQDRFPRDGYCEGTMIDGIYYLAFDQATAKKQMMSYIFDDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4U0</accession>
    <name>A0A174F4U0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase, IS30 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265334.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43195">
        <property type="protein sequence ID" value="CUO43195"/>
        <property type="gene ID" value="ERS852471_01552"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1780129at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="12768" checksum="1B08B7B0B0702B00" modified="2016-09-07" version="1">MSYKHITINEHCIIALGQFSNSNLKSLTVDRSKEFARYLELENKFNLHVYFADAYSSWQRGTNKNTNGLIRDFFSKKFDFSTVNQTHVDIVEDILNDRPRKCLGYKTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6A6</accession>
    <name>A0A174F6A6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capsular polysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="4">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">capD_2</name>
        <name evidence="4" type="ORF">ERS852471_01573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44346">
        <property type="protein sequence ID" value="CUO44346"/>
        <property type="gene ID" value="ERS852471_01573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="300"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO44346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="640" mass="71825" checksum="DB503984B732EDEB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F931</accession>
    <name>A0A174F931_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265412.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45179">
        <property type="protein sequence ID" value="CUO45179"/>
        <property type="gene ID" value="ERS852471_01591"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1897160at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010235">
        <property type="entry name" value="HepT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08780">
        <property type="entry name" value="NTase_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01987">
        <property type="entry name" value="HI0074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="131" mass="15616" checksum="0B178FE7F07E9BDA" modified="2016-09-07" version="1">MRSIDFKYMNLKKAYSRLKEVSDLYDGKDDIIRDSLIQRFEFTYELTHKTLREFMKYLGVTLENSFPRTIFKKAYVNNLISDDKVWINLLEDRNSTSHIYNENLADEVADRIVKYYVDAIGELVDNLEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCL3</accession>
    <name>A0A174FCL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein MviN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mviN_1</name>
        <name evidence="9" type="ORF">ERS852471_01613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265451.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46100">
        <property type="protein sequence ID" value="CUO46100"/>
        <property type="gene ID" value="ERS852471_01613"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879367at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO46100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="504" mass="56911" checksum="77D5489B20BBE705" modified="2016-09-07" version="1">MIKENRQLEKDIVVENSNKKAAKQLIIMIVLTILTQVVTILKTSTVASQFGATIQMDAFNFSTSIGTFIFSFIGAGVTTVLIPNLVKKDKKDSINIFISTLYTIAFLVLLIVYFFRRSIIGVLSSQNDEFILIASNIMLVTLLTQFITSFSGATNAIFQCKGKFNFPKLITLFTTIILIGLIVFMPNLTIYKYAAYIFVTSVLNIIIQIYLVKKNGYKFNYRIDFSDKEFKNMFRTFLPTVLSTGLYQFSLVTDTVISSNLGEGSTSILGYSNSLMTMVNSVILTNLMTYFYPKIAKSIGREDSQERVFDLMILLNGIMCLFLVGFIVVGKSGIILLYERGKFTPTITEMVYIGTLIYMIGIPVNAMRDLVYRYFYANGDTLTPFKNSIVISISNIIISIILSKIFGIYGIIIGTVITSFISFIMILFRFNKKFGFKCNKRKLIIENIKIVLVSITVIVTIKFLITMLPSMTLIIEILLVGIITTLLYTTMLVVFRSKIYKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FY05</accession>
    <name>A0A174FY05_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">srrA_2</name>
        <name evidence="11" type="ORF">ERS852471_01763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265725.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54307">
        <property type="protein sequence ID" value="CUO54307"/>
        <property type="gene ID" value="ERS852471_01763"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO54307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="26597" checksum="A20CD4EAFB8237FC" modified="2016-09-07" version="1">MEKILLIEDEASIRGFLKINLKRNNFDVLECDNGEEGIQIALLERPKIVILDVMLPGIDGFEVCKILREKISDIGIIMLTAKGQDMDKIIGLEYGADDYIVKPFNPMEVILRIKAILRRIGKEEKGNEILENGPFKIDLYSQKVSKNDVELDLTPKEYLLMKLFLENPKKAFTRDELLNILWGKNYFGDLKIIDVNIRRLRAKIENDSSAPKYIETIWGTGYRWNGKEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1P0</accession>
    <name>A0A174G1P0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nudF_1</name>
        <name evidence="2" type="ORF">ERS852471_01784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265766.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56373">
        <property type="protein sequence ID" value="CUO56373"/>
        <property type="gene ID" value="ERS852471_01784"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="200" mass="22566" checksum="622979C0A7E2ACB0" modified="2016-09-07" version="1">MKKTKIKDVEVLARTKFLSLYNAKYENKNGREKNWTIASRKGTEVLNETLLQGKEDKVDAVVIVAFHKSEKKLVLVKQFRVPINDYIYELPAGLVDQGEDALNSLKRELKEETGLDLVEIIPGIGRDKVYLSPGMTDESVNLVYCTCEGDISKDGLEEDEDLEPLLISKEEAKAILESDSKIDIKCLMVLQSFININTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G414</accession>
    <name>A0A174G414_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55559">
        <property type="protein sequence ID" value="CUO55559"/>
        <property type="gene ID" value="ERS852471_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO55559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="240" mass="27022" checksum="329F8FBD09F1B0D0" modified="2016-09-07" version="1">MQTRHMTLGHDPILGWIFGTLNIMTNTLTKNSPLLTTYIVKAHPTTGNYTQIGESVLISEVFINGVNLAKNDYKLLVVSIIRQALHFGADAFTKMGLPIPIINTISPDLSSKLLSENFRIDAYSVSRGIMLSTLINSIISAIHGLFYDEKVDIKRDLYEVRTRKILSYSNALATSSNTIYTAVTKDFTKLDVGGAVVTLYRLISDYSFISKVKYEFINEILDNELREEIKKIDDIYNEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4Y5</accession>
    <name>A0A174G4Y5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">scpA</name>
        <name evidence="3" type="ORF">ERS852471_01789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ScpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265776.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56667">
        <property type="protein sequence ID" value="CUO56667"/>
        <property type="gene ID" value="ERS852471_01789"/>
    </dbReference>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO56667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="30436" checksum="58A2F02B413EB351" modified="2016-09-07" version="1">MELLKIKVADFEGPFDLLLHLIKKNKMDIYNVEIYKITNQYLESLNEMKEMDLEITSEFVVIAATLIEIKSKKLLPKVKEEEEENEEDIEKRLMEKLIEYKKFKGVSEFFKERYTSAGEVYSKKPEVIEEVEKPEEKVVESFEDIFKNITLLDLYNIYNRILENYREKQNVANVVQKRIYVDKYKIEDKMNTLIKKFENDEVVEFSSIMMESECKMETVVTFLAVLELIKIRVIKVYQEDNFGNILMKRRRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7L4</accession>
    <name>A0A174G7L4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAE2</name>
        <name evidence="2" type="ORF">ERS852471_01818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265834.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58001">
        <property type="protein sequence ID" value="CUO58001"/>
        <property type="gene ID" value="ERS852471_01818"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455925at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014245">
        <property type="entry name" value="Spore_III_AF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09581">
        <property type="entry name" value="Spore_III_AF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="22219" checksum="10699BFBD2D0B8BC" modified="2016-09-07" version="1">MEYIKSFIIALVTTIIFITAVEMIAPDKPIKKYIKFVLNLVLVSVLLNPIVYLFTKGEGEIIGAIEKYEQILSQGTISNDNSAVNDTRVEAFKENLNKNCAMLLEDKFDGKKFECDVICTVDLENMTYNIEKINVGVKDNKIKLIEKIKIDTSKSTEVMSSNEEIEGSEEIIDYLTEELNVSREKIEVYKVERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9C5</accession>
    <name>A0A174G9C5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265877.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59013">
        <property type="protein sequence ID" value="CUO59013"/>
        <property type="gene ID" value="ERS852471_01841"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1477108at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040591">
        <property type="entry name" value="YlmH_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17774">
        <property type="entry name" value="YlmH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29456" checksum="C8D245F8612DF453" modified="2016-09-07" version="1">MIKKEEVIRNFSKEERDEVVKIYEWMELAYEKEIPLFSRSFCTPNIWLYFVNNFNSKNFKVEANGYFEESDRRVLSFNNIYGSDYPYKLIKIEKKSKFDSLSHRDYLGSIMALGMEREKFGDLRVYENYAVVPVYEDVVEYVISSLNSVGKSPVSCEVINDTTLSKVNFLEVIINVSSLRLDSIVSKLSNISRSKALDLINQNKILVDYCKVNSKSLEVKEGQRITIAGVGKYIMGNIVGNTKSGRFKVNIKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9E3</accession>
    <name>A0A174G9E3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59092">
        <property type="protein sequence ID" value="CUO59092"/>
        <property type="gene ID" value="ERS852471_01843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO59092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="26964" checksum="F5B16AE056F20C53" modified="2016-09-07" version="1">MGFWRIKICRRFSIKEGLIIDIKGKIKEILNSIPDDVQLVAVSKTKPVEDILEAYDIGIRNFGENKVQELVDKYEKLPKDIKWHLIGALQMNKVKYIVGKVSLIHSLSSIKLLEKIELEYGKKNITADVLIQINIGRESSKSGILEEELDQLIEAVEKCKNIKVKGIMVIIPKGNDEENRYYFRRTYDIFKTLKNSNYKNITMEILSMGMTHDYKIAIEEGSNLIRIGTGIFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDY9</accession>
    <name>A0A174GDY9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="8">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">mraY</name>
        <name evidence="9" type="ORF">ERS852471_01849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59348">
        <property type="protein sequence ID" value="CUO59348"/>
        <property type="gene ID" value="ERS852471_01849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO59348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="34581" checksum="52371434BDC2AFBC" modified="2016-09-07" version="1">MINIITSKYAIAAVLSLLISLALGPIAIPALRRLKFGQNIRKEGPQSHLKKAGTPTIGGLIFIGSTLITMIALRLKWNDEAMIALYSLIAFGFIGFLDDLLKIIKKDNEGLKAWQKMVLLLVFSGAIAYYGYLNLSTGMIIPFLGKKVALGMFYIPFVIFIYAATTNAVNLTDGLDGLASTVSVLVLTFFAVSAFILGHDSVGLFCIALIGGLIGFLKYNAYPAKIFMGDTGSLAIGGAIATIAIILEIPLLIPVVGGIYVLETLSVIIQVTSFKLTGKRIFKMAPIHHHFEQCGWSEVKIVTVFSIVTVILCMIGFWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGE6</accession>
    <name>A0A174GGE6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.187</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">N-acetylmannosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmannosamine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tagA_2</name>
        <name evidence="3" type="ORF">ERS852471_01865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1-&gt;4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:16053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:62959"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:132210"/>
            <dbReference type="EC" id="2.4.1.187"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; teichoic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.187" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265922.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60066">
        <property type="protein sequence ID" value="CUO60066"/>
        <property type="gene ID" value="ERS852471_01865"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="UniPathway" id="UPA00632"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02070">
        <property type="entry name" value="TagA_TarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034714">
        <property type="entry name" value="TagA_TarA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="28216" checksum="8F904C041B216618" modified="2016-09-07" version="1">MIENREGYIEILGYKIFSGTKKECLDKVFSYEKVHVISGNPEVLYTGLRNEKLLENFKSNKVLIIPDGVGTQISGRILKTPVKEKIAGIELMKEIIKRCNENGEGIYLLGASQDSLDACKDKLLEEYPQVKIVGARNGFFDIENADEIINDIKDKKPLALFVAMGCPRQENFIVKYMDELPVKIFMGVGGSFDVIGDKVKRAPRWMINIGMEWAYRVIKEPFRIKRLGSIPKFLWLVVKDRGTSYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKL0</accession>
    <name>A0A174GKL0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_01916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62893">
        <property type="protein sequence ID" value="CUO62893"/>
        <property type="gene ID" value="ERS852471_01916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="310"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO62893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="548" mass="61506" checksum="56C871E8F2DDEC27" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVD9</accession>
    <name>A0A174GVD9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ywqF_2</name>
        <name evidence="2" type="ORF">ERS852471_01969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65088">
        <property type="protein sequence ID" value="CUO65088"/>
        <property type="gene ID" value="ERS852471_01969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="32" mass="3264" checksum="114777B9A622F050" modified="2016-09-07" version="1">MNIVIAGTGYVGLVTGACLSEIGHKVTCIDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYX7</accession>
    <name>A0A174GYX7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266228.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67972">
        <property type="protein sequence ID" value="CUO67972"/>
        <property type="gene ID" value="ERS852471_02028"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2151084at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="12912" checksum="C63963766AEA02CF" modified="2016-09-07" version="1">MSVNPDGTPGMTTIHAWKYEINENGNDTVTIELTDGQNAQNLIKDGARGSILVDNNGFQLIHLKTINVETLEYTDENYENGLFNSAYTGADNKLSEYNITLEVMVIEKAPTIMFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYZ7</accession>
    <name>A0A174GYZ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266147.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66019">
        <property type="protein sequence ID" value="CUO66019"/>
        <property type="gene ID" value="ERS852471_01993"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1009891at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045678">
        <property type="entry name" value="DUF6198"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19700">
        <property type="entry name" value="DUF6198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022951" evidence="2">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO66019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="22929" checksum="84898F7DE8B886E2" modified="2016-09-07" version="1">MKKIKRYATFLLGIIILTLGVALIAKADIGNGSFDSINFGLQSKFGGNLSFWVAVSSLIALIIASIVNKKIPNIFSFITAYIVGVFIEIWIKITEPIVINSLVSKYLVFLLAIVILAIGISIYLLAKLPPNAIDYLVLTLSETYKIKLGTIKLIVDFICIVLALIVKGPIGIGTILATVLLGPMINIVQKPIENIFVGKEEIVINEEKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6W2</accession>
    <name>A0A174H6W2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_8</name>
        <name evidence="6" type="ORF">ERS852471_02081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266312.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69941">
        <property type="protein sequence ID" value="CUO69941"/>
        <property type="gene ID" value="ERS852471_02081"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="449" mass="49120" checksum="1ED02192143C878C" modified="2016-09-07" version="1">MDINEVLNMNIFKVWSKFVVASMVGIVLNTIYTMVDGIFVGQGVGEAGLAGVNIAWPAVTLVVGIGLMIGIGTSSIIAIHMGRGHKEKAEKCLGTAIKSIIIIGSIVMILGLIFREPIIKMLGATADTIGYARDYYTIIFIISIPYIFSTALNPIVRTGGRPDLSMIMIGVGAIANIILDWLFVMKLGYGVKGAALATSASIFISMVISLLHFLKGKSNIKIKKEYFKIDLRNLKKILKIGFVSFAVQLSYGIILLVQNRTMFAYGNTVDVAIYTVATYINCFLVNTCMGIAQGLQPLIGYHYGANKLERMKKLLYITIVICVIGGVLVYTSIVFYGREMISIFGIGSESLDFAYDKILIYCIGSPIIGTIFTMSGYFQAIGKNIYANIISIGRGFVFQFLFTLILPPFIGVTGVFLSLPLAELITLIILVYIIFVESNKRSKQNVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8R7</accession>
    <name>A0A174H8R7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
            <ecNumber evidence="3">2.7.7.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pleD_2</name>
        <name evidence="3" type="ORF">ERS852471_02067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.65" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266291.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69409">
        <property type="protein sequence ID" value="CUO69409"/>
        <property type="gene ID" value="ERS852471_02067"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="567"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="699" mass="81620" checksum="CC4C309E44A7E1E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HA01</accession>
    <name>A0A174HA01_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266310.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69920">
        <property type="protein sequence ID" value="CUO69920"/>
        <property type="gene ID" value="ERS852471_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="131" mass="14390" checksum="814B50F3CFDB5BA8" modified="2016-09-07" version="1">MDLIIKEVAATINCNTCPCDTSVVYDAGTITPDTQVSLIDFNVTLNNVCVDSRFGIFVRIYFTPNGGTTSLVGIAGKSIDVDEYVDEADSGCYDDVTIPFEDVVVWVPYCFNGTFSFEVFGNYLQCPDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAD5</accession>
    <name>A0A174HAD5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease RNase T and DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266332.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70347">
        <property type="protein sequence ID" value="CUO70347"/>
        <property type="gene ID" value="ERS852471_02091"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="244" mass="28781" checksum="2A72330F8A801A1D" modified="2016-09-07" version="1">MNYIIFDLEFNQQHPDNKTTEKSPLMFEIIQIGALKLDSNFNTISTFNSFIKPTVHKLIHPYVEELTNINYEQINSAKFFIDVYKDFINFIGTEDATLVLWGVNDIKELIRNANYYKLSSDAIPKKYIDIQCYLSKALKYSKGRKIGLKVATEQLEIPIESEFHDAFNDAYYTAEVFKKIYNKRMKPQLYIYTDNKREKHTKTSIDTSALINQFEKMYNRNITDEEKDMIKLAYMMGKTNQFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLM3</accession>
    <name>A0A174HLM3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_10</name>
        <name evidence="6" type="ORF">ERS852471_02180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266502.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74197">
        <property type="protein sequence ID" value="CUO74197"/>
        <property type="gene ID" value="ERS852471_02180"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO74197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="439" mass="48018" checksum="5A9F3232B4C8CB32" modified="2016-09-07" version="1">MTDNKTLRKSFFRNLIPSVTAMWVYSIYTIIDGIFVGKGVGSTALASVNIAMPFVNLIFASSIFFATGTSTLISIRLGQDKKDEANNIFSFNVAIMIIFSIILLAFSLIFINKISIFLGATESTFKMVKDYLSIIILFNGFFIVSYCLEVLTKADGFPNLAIIGVSISAITNIILDYLFVIKFGFGVKGAAIATGISQVASCLFFTLHFLKPISTLKFVKFKPSFNIFKRIISIGFPDGITELTSGIVILIFNQSILKFIGENGLVTYSVICYVSTLVLMTMIGITQGAQPLCSFYYGSEDVKSLKYLFSITLKTIAIVSVGIFIICILFSPSIINVFIASNDSALINQSIIIFRIYSLSFLLVGFNILSSGFCSSIESPILATLISISRGLVIIIITLIITIILYGGNGIWIATILSEAICLLISVWSIKISFKNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPF4</accession>
    <name>A0A174HPF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266626.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76842">
        <property type="protein sequence ID" value="CUO76842"/>
        <property type="gene ID" value="ERS852471_02256"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2168143at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO76842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="100" mass="11227" checksum="77BB765E61F4A39F" modified="2016-09-07" version="1">MNHIFYISNDCIEVFLSDTSSTEDDELLAKALNFMRNSGLTVTLKGFDKYNRAIVDIDGVIHTAAKNGSLCQSQRFITAKHKISVVENSERYNNIVKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HUN7</accession>
    <name>A0A174HUN7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-3-phosphoglycerate dehydrogenase SerA</fullName>
            <ecNumber evidence="6">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serA2</name>
        <name evidence="6" type="ORF">ERS852471_02293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266687.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78604">
        <property type="protein sequence ID" value="CUO78604"/>
        <property type="gene ID" value="ERS852471_02293"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="8"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="108"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO78604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="304" mass="33692" checksum="9F31D4A7A40A3B91" modified="2016-09-07" version="1">MIKVLTNDGLQQEAIDNLKLLGIEVTNYHYSKEELKNILKDFDVITIRSATKIDSDILDSLTNKSNLKLIIRAGVGVDNIDVTYANKLGIEVRNTPNASSDSVAELAIAHMFSVARFLADSNFTMRMGSWNKKEYEGVELAGKTLGIIGMGRIGRSLAKKASAIGMNVVYYTIEGKYDDLTYKFESLEDLLSTSDFISLHVPYDKKTGYLIGKREFELMKEGVYLINCARGKVVDEEALVEALDNGKVAGAGIDVFEQEPTLNKKLINHKRVSVTPHVGASTKEAQDRIASEVVNIIIDFFDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HVH8</accession>
    <name>A0A174HVH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77148">
        <property type="protein sequence ID" value="CUO77148"/>
        <property type="gene ID" value="ERS852471_02264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06166">
        <property type="entry name" value="Sortase_D_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042000">
        <property type="entry name" value="Sortase_D_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO77148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="21795" checksum="78D235626CB976D5" modified="2016-09-07" version="1">MDKFRRGIGLLLIAVGLIIIGTVVYKKVETIRKQKAVIEMFESSISEGSLTSKEEVNLEDINGYTPIAIIEIPSIKLSQALVEGISDDVLKYFLGHFNDSAAPGEKGNFAVAGHRVSDYTDAFINLYKVKAGDEVIVKTHDKKYTYVVEDNFIVEPEDVHVLDDTKEATMTLVTCTVGAKQRVIVKGRLISEEELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I0X1</accession>
    <name>A0A174I0X1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tadA</name>
        <name evidence="5" type="ORF">ERS852471_02308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79018">
        <property type="protein sequence ID" value="CUO79018"/>
        <property type="gene ID" value="ERS852471_02308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO79018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="16055" checksum="5D25A5B2A17D7A66" modified="2016-09-07" version="1">MDLALDEAQKAYDLGEVPVGAVIVKDGEVIAKACNMKEAMKLSTAHAEVLAIEEASKAIGDWRLNGCDMYVTLEPCAMCAAAIAHSRISNLYIGTFNIDMGACGTVINLLDYDIFNSRVNTNWCYDKRCSDMLTKFFDTRRKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2P4</accession>
    <name>A0A174I2P4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266820.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81444">
        <property type="protein sequence ID" value="CUO81444"/>
        <property type="gene ID" value="ERS852471_02378"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2054164at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO81444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="86" mass="9710" checksum="08061799EA1B80B1" modified="2016-09-07" version="1">MFLHLGENVVVPIKDVIGIFDIETSMYSSDTISFLRMAEEDGFVERITKEAPKSFVIAEVNKMSKVYLSPISSSTLTKRTNIDYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I554</accession>
    <name>A0A174I554_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yidD</name>
        <name evidence="2" type="ORF">ERS852471_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266810.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81166">
        <property type="protein sequence ID" value="CUO81166"/>
        <property type="gene ID" value="ERS852471_02371"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO81166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="70" mass="8084" checksum="0EFC6A59A52D4862" modified="2016-09-07" version="1">MKRLLLKLIHLYRKYYSPTRPACCIFVPTCSQYAEEAITKYGVAKGGYLSIKRILRCNPFNKHGGYDPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IAH8</accession>
    <name>A0A174IAH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltose O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
            <ecNumber evidence="3">2.3.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EC" id="2.3.1.79" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82627">
        <property type="protein sequence ID" value="CUO82627"/>
        <property type="gene ID" value="ERS852471_02395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008925">
        <property type="term" value="F:maltose O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO82627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="21063" checksum="FFA130076EBB6D70" modified="2016-09-07" version="1">MSKDLLKRLETMEFISHKDAIFTEINAILEETLKLTNELNLGYKAPEEVREILAKITDSEIDNSVQVLTPFNTDFGRNIKIGKDVFINKSCMFVDLGGITLEDNVLVGPEVKILSVNHPIEPQNRRGVIIKSVKIKRNAWIGAGAIICPGVTVGENSVIGAGSVVTKDVPDNCVYAGVPAKFIKNIEVESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IAN8</accession>
    <name>A0A174IAN8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_2</name>
        <name evidence="5" type="ORF">ERS852471_02441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266932.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84352">
        <property type="protein sequence ID" value="CUO84352"/>
        <property type="gene ID" value="ERS852471_02441"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="311" mass="34571" checksum="D156E3F3B0D02C8C" modified="2016-09-07" version="1">MKVIEIRDLVKKYGNNIAVDNINLSIDEGEIYGLLGPNGAGKSTIINMLCSLLKPNSGSLKIFGVDVQEHNMDVKKKIGLVPQNVAVYKDFTAYENVKFFGELYGLRGNKLKESVNKALEFVGLLDVAKDQAKSFSGGMVRRLNIACAIVHEPKLIIMDEPTVGIDPQSRNHILNAVKTLNKNGTTIIYTTHYMEEAENLCSKIGIIDKGKIIVEGSTDELKSMVSDKKTLQIRVDDVYKLEIENIKKIKGVSEIIIDQNCLTINTQKEINNLDILIKSITDSNVKILDLGFKEITLETVFLTLTGRSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IAX5</accession>
    <name>A0A174IAX5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ypdC_2</name>
        <name evidence="4" type="ORF">ERS852471_02399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266860.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82777">
        <property type="protein sequence ID" value="CUO82777"/>
        <property type="gene ID" value="ERS852471_02399"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="249"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO82777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="351" mass="40244" checksum="62056CABFF997136" modified="2016-09-07" version="1">MNFLNLDTYLSLSSSEMMYKNIFINNPEFTLDKAKTVKHVSSLLDSLCNCKKGGSDSSYDPSREFMEENIIPAPYDVLVSKHLRYSPCFIHTHSFFEVIYVANGSCINEISDQSINMKKGDLCILAPGTSHAISVFNDDSIVFNLLIKASTFESAFFGTLRNKDILSSFFSRALYSPTSESYLLFPTGNDIIIQSLILEMHSEFNLSLSYSERMLNTLTTKLFITLLRSYEETVIVPNPLGNTLDTNIVNIMNYISSNYKSITLKDLSVYFNYSERQMSRILKDYIGKSFINIIQDIKTQKACELLRNADISINNIIDIVGYSNTSHFYRVFKKQYNMTPVEYRNKYIYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IIN8</accession>
    <name>A0A174IIN8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lldD_2</name>
        <name evidence="3" type="ORF">ERS852471_02455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84845">
        <property type="protein sequence ID" value="CUO84845"/>
        <property type="gene ID" value="ERS852471_02455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="2">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO84845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="12908" checksum="B70ABB38D35F3D70" modified="2016-09-07" version="1">MDYQEVLKNARDCIGEYCKACNECNGKVCKNQIPGPGAKGVGDTAIRNYDKWKEIRVNMDTLTENKKVDMSIELFGQTFKYPFFAGPVGAVGLMSIFWTQKVKLFYAALLANNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ILK9</accession>
    <name>A0A174ILK9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ORF">ERS852471_02476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267004.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86238">
        <property type="protein sequence ID" value="CUO86238"/>
        <property type="gene ID" value="ERS852471_02476"/>
    </dbReference>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="67"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="358"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO86238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="461" mass="50830" checksum="6AC81430968782E4" modified="2016-09-07" version="1">MAKIKTVYICRDCGYETPKWLGKCPDCNNWNTFEEEVVQAKSTSKTVTATRTPKKVAKKLTEVTSSKSDRIVTGINEFDRVMGGGIVKDSITIITARPGAGKSTLLLQVADCIAKKGHKVIYASGEESDSQIKNRADRILEKINDNIWVLQETNLDNVVDSIEEIDPDLIIIDSIQTFTMEGYLPARAGSPTQTMECANELLRVAKNDKRQRAVIIVGQMTKADELAGLRALEHLVDTVLIIEADSDEELRGLVSSKNRFGSTGETGFFQMTEKGMMSIDNPSEFFMTKRDEGELVSGSTLTVIKEGSRAIITEIESLVSKTFTPYPTRIGETLGKDKLNTLISILEQRGGINLYDKNVIIKTTGGMRIREQGINLAVIMSIVSSVKQKGIEGNIAFIADVGLTGELKKVPSLEGRVKELARMGFKRVYVAKDSFAKGTVFKGIEVIALKTLNDVIFHVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IMU3</accession>
    <name>A0A174IMU3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267089.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88643">
        <property type="protein sequence ID" value="CUO88643"/>
        <property type="gene ID" value="ERS852471_02536"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="174" mass="18966" checksum="BF898DC2A052C075" modified="2016-09-07" version="1">MEILIKLYFVFLKIGTFSFGGGYAMLPFMQREIVENNCWISMSQFSDIIGISQMTPGPVAINSATFVGYKVGGVAGSVVATLGVITTSFILVTIINKILDKFKESITVKAMLAGMRPILIALIIYAFIDLAKESYVDLKSIIITIIIGIILVSKKVHPILVIVIAAILGLIFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVZ4</accession>
    <name>A0A174IVZ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cardiolipin synthase</fullName>
            <shortName evidence="12">CL synthase</shortName>
            <ecNumber evidence="12">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">clsC</name>
        <name evidence="14" type="ORF">ERS852471_02550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phospholipase D family. Cardiolipin synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267115.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89767">
        <property type="protein sequence ID" value="CUO89767"/>
        <property type="gene ID" value="ERS852471_02550"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01916">
        <property type="entry name" value="Cardiolipin_synth_Cls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030874">
        <property type="entry name" value="Cardiolipin_synth_Firmi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO89767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="479" mass="55299" checksum="53D2CB2BA0405744" modified="2016-09-07" version="1">MFKFLTILIHLINFFTIVYMVFKEKRPANSIIAWTLILYLAPFIGFIAFLLVGRRLNNANMFGVKDSELKIFNIYNDYIKERELFKSTNKNLKNLDMIMSLEAIEFSPYRDDNNIELFSDGKIFFEELLESLKKAKKSINIEFYIFKSDDIGSKILNILEEKARAGVEVRFLYDSVGSRSLNKTRLKPLIDAGCKIGEFFPSWLKIINLNMNFRNHRKIVVIDNTIGFVGGFNVGDEYLGKDKKFGYWRDTHIKFEGSAVKDLNLRFLADWRYATKEVVDLEKILVFDESNLKPANDGMQILSSGPNLSDNYEIKLGYLKMIQKAKDYIYIQSPYLIIDKSISDSLKLAALSGVDVRIMIPGKGDHPFVYWANLFYAGELLDSNVKIYHYDKNAFLHAKTVVIDDEICSVGTANMDTRSFELNFEVNAFIYSEKIAKEQKQEFKKDILKSTQLTLEAYNNRGRSAKIKESFSKLFSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IY36</accession>
    <name>A0A174IY36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Topology modulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267233.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92333">
        <property type="protein sequence ID" value="CUO92333"/>
        <property type="gene ID" value="ERS852471_02618"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO92333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="64" mass="7876" checksum="DABBA3C565238A9A" modified="2016-09-07" version="1">MGGNCQERFDLEFLKFVWKFNKNNRNNYYKLLEEAKGKKIIILRNRRETAKFIKEYSEIREGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J361</accession>
    <name>A0A174J361_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble spore protein C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sas2_2</name>
        <name evidence="4" type="ORF">ERS852471_02631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267259.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93131">
        <property type="protein sequence ID" value="CUO93131"/>
        <property type="gene ID" value="ERS852471_02631"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2064087at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO93131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="6598" checksum="C063091761D3E372" modified="2016-09-07" version="1">MAQKLVPEAKNGLAKFKNEVANEMGVPFTDYNGDLTSKQCGSVGGEMVKRMVEQFEQGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JFA1</accession>
    <name>A0A174JFA1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lon_2</name>
        <name evidence="3" type="ORF">ERS852471_02686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO95800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267364.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95800">
        <property type="protein sequence ID" value="CUO95800"/>
        <property type="gene ID" value="ERS852471_02686"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="546"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="636"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO95800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="765" mass="87472" checksum="F9D4BE760291325F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JHL1</accession>
    <name>A0A174JHL1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">era</name>
        <name evidence="13" type="ORF">ERS852471_02731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9 10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267446.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97676">
        <property type="protein sequence ID" value="CUO97676"/>
        <property type="gene ID" value="ERS852471_02731"/>
    </dbReference>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="12">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="9">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="9">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="9">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="9">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO97676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="34005" checksum="ACA798321E37F6F0" modified="2016-09-07" version="1">MYKSGFVTIVGRPNVGKSTLLNQIMGEKLSIVSNKPQTTRNNIQTILTGEDYQIVFVDTPGIHKPKHKLGEFMVNSAKESIKEVDLVLFLINPDEEIGRGDKFILEALKEQKAPVFLVVNKVDENSHEKVAKTLQMYSAEYNFKEIIPISALKGKNVDTLVNLMKDYMPEGPQYYPEDMITDVQERFIVSEIVREKALRNLRDEVPHGIAVDVIQMKQKENGTYHIEVDLICEKDSHKGIIIGKNGTSLKKIGETSRYEIERFLRAKVNLKIWVKVRKEWRDNNLLLKELGYKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JIE0</accession>
    <name>A0A174JIE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium channel subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kcsA_2</name>
        <name evidence="10" type="ORF">ERS852471_02767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267507.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99443">
        <property type="protein sequence ID" value="CUO99443"/>
        <property type="gene ID" value="ERS852471_02767"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1991946at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="9">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO99443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="29090" checksum="325479FEBF31FAFF" modified="2016-09-07" version="1">MNKKTVYEFFIGLLALLLALMLVIDIFIPLPKEVTLSFYYIENIVRLIFIGDYVVRFVISKGKREFIKNNMIDLLSIIPLRAYVKIAAVINLAYIIEPNIIIKIFKIFMLGIFFIKFKVKTKEEIRTNRVYYLLIISTTIIVIGAVIISLIEGISLGDALWWSFVTFTTVGYGDVVLKTQLGRSIAVILMVFGVGFIGITSTAIALRVLNGGKKEKNNSYKNEVLEGIKLMLDNYDSLSDEDIDNIVKILKSLRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K0S1</accession>
    <name>A0A174K0S1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndoA</name>
        <name evidence="4" type="ORF">ERS852471_02837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032120348.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02970">
        <property type="protein sequence ID" value="CUP02970"/>
        <property type="gene ID" value="ERS852471_02837"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP02970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="117" mass="12960" checksum="113D57888F1ECC76" modified="2016-09-07" version="1">MTTMVVKRGDIFYADLSPVIGSEQGGIRPVIIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEISSEEYGLNRDSVVLLEQVRTLDKRRLKEKIGHMTDADMKKVDRALLISIGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K1Z6</accession>
    <name>A0A174K1Z6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267691.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04436">
        <property type="protein sequence ID" value="CUP04436"/>
        <property type="gene ID" value="ERS852471_02865"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1675445at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP04436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="89" mass="9992" checksum="63E6DF463E67FA1B" modified="2016-09-07" version="1">MQVIKKDGRLQELDANKIKISILNATSGTKALLNESDIKIIVKDIIKIIEDLRSEYGNTSSYEIVGVVVEVLKRDGFDDVISSYIEYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K368</accession>
    <name>A0A174K368_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ErfK/YbiS/YcfS/YnhG family protein</fullName>
            <ecNumber evidence="4">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ykuD_2</name>
        <name evidence="4" type="ORF">ERS852471_02861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04278">
        <property type="protein sequence ID" value="CUP04278"/>
        <property type="gene ID" value="ERS852471_02861"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP04278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="19080" checksum="4331C24A4FA596EC" modified="2016-09-07" version="1">MLINILKNIYRATKLNTTVLSDFLLVNSLSSYGESFVNNSNLSSTTNYLIWVDTQSFKVNIFTGKKSNWKLIKSYSCSIGKPTTPTPKGTFYIGIKGYSFGYSHGYVCYYYSQFKNDYLFHSILYNLDGTIKDGRLGMKISNGCIRLAKVNAKWIYDNVPAKTTVFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KD59</accession>
    <name>A0A174KD59_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267833.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07748">
        <property type="protein sequence ID" value="CUP07748"/>
        <property type="gene ID" value="ERS852471_02944"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="191" mass="22335" checksum="C9AD470E71E65CE1" modified="2016-09-07" version="1">MEQKSTDRRIRKTKNALKDGLIELMLEKSINDITVRELTEKVDLNRGTFYLHYKDIFDLLEKIEEELFEEFNKIMDAHSPDKLDGRPLPLLEDIFMFLKDNASMTTVLLGRNGDIAFVNKIKDIIRKNCFTSWSAFFNSENMNNFDYFYTYILSGCLGLFEAWLNNGLKESPHEIALLTESFILHGFQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KRN8</accession>
    <name>A0A174KRN8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268053.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13106">
        <property type="protein sequence ID" value="CUP13106"/>
        <property type="gene ID" value="ERS852471_03056"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1804079at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="128" mass="15546" checksum="C7B9282DF5506BF8" modified="2016-09-07" version="1">MVKRDMFYFADIDEKFIDSTKDSIGLEDGVLVHCQQCIEKNLKAIIQKKYGMISREHNLVKLLEVLYLQDYSELKKYKSLCRDLKDFYFSRRYASDDYEVLTHEEYLEYIDKFYELLNEIKVIRQELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LC17</accession>
    <name>A0A174LC17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chain length determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cap8A_4</name>
        <name evidence="9" type="ORF">ERS852471_03195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268295.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20431">
        <property type="protein sequence ID" value="CUP20431"/>
        <property type="gene ID" value="ERS852471_03195"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25026" checksum="22F96F206ED929FC" modified="2016-09-07" version="1">MTGLRVENIIKVLKDNIRLIIISTLTVTLVAAIITFFFISPQYEATTKVFIGKENFKNVSSDYTNEEITLYQRLLKTYSEIFKTKNLMSKAISNVGEDVTVEEAMSKSSAVPISDTQILKLKYVSDSKEESYNMIYGLTEEFMKLSKTLYPNGNVYIIQQPIIPVNPIGPNKVMNILIGLILGLAIGIGIVLFKEFINNVFKSKSEIEETLDIPCLGIIPNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LDH7</accession>
    <name>A0A174LDH7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4829 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20567">
        <property type="protein sequence ID" value="CUP20567"/>
        <property type="gene ID" value="ERS852471_03198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032256">
        <property type="entry name" value="DUF4829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16111">
        <property type="entry name" value="DUF4829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026979" description="DUF4829 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4829" evidence="2">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP20567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16064" checksum="031F488A2892E761" modified="2016-09-07" version="1">MKKIIILFCCLLSVFSLVACNKGSVSNDILIEVSKSTKFSKDEIENAIQNVKSNFSFPGATLTKIWYDEEKSNYLIDSYLENGRGLTNGVKEENVIILLSNFDVDGSGDNPVLNPNTTYSDYQWILIRDSKNNVWKIDDFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LFC8</accession>
    <name>A0A174LFC8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_03216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268334.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21591">
        <property type="protein sequence ID" value="CUP21591"/>
        <property type="gene ID" value="ERS852471_03216"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1230456at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026903" description="Lipoprotein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP21591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="29873" checksum="C89DAEB0FA0A8D94" modified="2016-09-07" version="1">MKRKSILSLVLTGVLAISLIGCGGSNSSSSDDKTIRIGVSPVPHKEIVEQAVEELEDKGYTVEIVEFDDYVLPNTAVEEGELDANYFQHIAYLNTFNEENGTHLTYTAEIHLEPMGAFSNKYKSVDEIEDGATVAVPDDSSNETRALRVLEAAGLIELAEGDILKVTDIVSNPKNLQFNELTAASLPRVLEEVDIAVINGNYALEAGLDVNENAFYSEDKDKDSLKERRNVLAVKEGTENSQKIKDLTEALTSDKVRDFINEKYKGAVVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LH58</accession>
    <name>A0A174LH58_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LD-carboxypeptidase family protein</fullName>
            <ecNumber evidence="6">3.4.17.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldcA</name>
        <name evidence="6" type="ORF">ERS852471_03256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.13" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268407.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23684">
        <property type="protein sequence ID" value="CUP23684"/>
        <property type="gene ID" value="ERS852471_03256"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106415">
        <property type="term" value="F:muramoyltetrapeptide carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="171"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="287" mass="31863" checksum="C386D0A32DB16BC2" modified="2016-09-07" version="1">MSLLQKGDKVGIVACSNGQSLLNKERINELLKTLKSINLNPICSDYIYAKNSIFNGSAKEKGESFMSLYRNIEIKAIFDISGGDLANEVLPYLDYEFISKNPKPVFGYSDVTTVLNAINSQASIPTYLYQIRNLIYDFKEMQQTNFENSVFNDKNDLFNFSYNFIQGEKIEGIVVGGNIRCLLKLAGTKYMPDFTGKVLFLESMGGEAALMSAFLNQLKQLGVFDKINGLILGTFSKMQENNISPSITELALSIIDNPTLPIAKTEEIGHSSNSKSIIIGKNIVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFE0</accession>
    <name>A0A173XFE0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mviM</name>
        <name evidence="2" type="ORF">ERS852471_00006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262674.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49098">
        <property type="protein sequence ID" value="CUN49098"/>
        <property type="gene ID" value="ERS852471_00006"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="34617" checksum="50198CBC1D5733B6" modified="2016-09-07" version="1">MRIGIIGIGDICKKAYLPVLTARGDIELILCTRNTKTIDEIKSKYRINEAYTNIEDLIKSGIDGVMVHSSTDSHFKICKTLLENKIPVYVDKPISYDYKEAEELYELSKKNNTKIMVGFNRRYVPKVKELKELGNPDIIIMEKNRVNLPGETRVFVFDDFIHVVDTVRFLMGADYTDMSVKYKKDSRGLINVVLTLTNENTTAIAIMNRDNGAVEETIEYMASGKKAVVTSLVKTTKFENNKISTEEFGDWTPTLYKRGFENIIEEFIGFIKEKNNSNKYIEDALKTHKICEDIVNYIENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNN1</accession>
    <name>A0A173XNN1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53183">
        <property type="protein sequence ID" value="CUN53183"/>
        <property type="gene ID" value="ERS852471_00078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="37" mass="4414" checksum="D9C955E01AB5505F" modified="2016-09-07" version="1">MTLKSLKNKTIIKANINYAYVHNVKFIMNYEEIQVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XX70</accession>
    <name>A0A173XX70_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspC_1</name>
        <name evidence="4" type="ORF">ERS852471_00152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262926.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56652">
        <property type="protein sequence ID" value="CUN56652"/>
        <property type="gene ID" value="ERS852471_00152"/>
    </dbReference>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="34"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN56652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="44993" checksum="CF752583F898B735" modified="2016-09-07" version="1">MVSKSMETLMKNNSVIREMFDEGKRLEQLYGEENVFDFSIGNPNVTPPNEIKENIIKILNEENPLEVHGYMNNSGYFSVRENIAEHLTKTKGIQLEDKNIIMTCGAAGGLNIIMKTLVNPDDEVIIFAPYFGEYINYINNYNGKTVIVSCDKNNFEPNLDELKEKITAKTKAVIINSPNNPSGVIYSEEIIKAISNILRESSEKLGTEICLISDEPYREIVYDGVEVPFILKYYHNSLIVYSYSKSLSLPGERIGYIVVNPKMNNISKILAALNIANRVLGFVNAPSLFQKVVGRSLDLEVDVNIYKKNRDLLYNHLVSLGFKCLKPNGAFYLFPKSPIEDDNKFCNELKKFNILAVPGSVFGCNGHFRLSYCIKYEKIENSLKAFDKVAKLYSDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XY69</accession>
    <name>A0A173XY69_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">infB</name>
        <name evidence="12" type="ORF">ERS852471_00158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262936.1">
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</entry>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="37"/>
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        </location>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN64391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="422" mass="47606" checksum="197F4B945B3EA217" modified="2016-09-07" version="1">MKPLADLVRPKKLSEVYGQQHILGENKILDRIVKSGRISNMIFYGPPGVGKTTVANIIAEKAGKRFYKLNATNASLKDIQDITKELDTFMGINGVLLYLDEIQNFNKKQQQSLLEYIEDGRITLIASTTENPYFYIFKALLSRSTIFEFKPLSEEDIKKAINRAIDIKIKDYSEIKLEVTDEAKMYLASYCNGDVRKALNGLEVALNSTKPNEDKVILIDIDVVKDSTQNKVISYDMDGDAHYDVLSAFQKSIRGSDPDAAIHYLARLVKAGDLISICRRLQVIASEDIGLAYPQAALIVKSLVDSARELGFPEARIPLAEATILLATSPKSNSAYLALDAALRDLEDITIGDIPRHLKDAHYSGASKLGRGLEYKYPHNYPKHYVEQQYLPDNIKDRSYYKYGDNKFEKATKDYWRAIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNH0</accession>
    <name>A0A173YNH0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YkwD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ykwD_1</name>
        <name evidence="2" type="ORF">ERS852471_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64328">
        <property type="protein sequence ID" value="CUN64328"/>
        <property type="gene ID" value="ERS852471_00260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="157"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="31197" checksum="EB1F9548DA2C68E5" modified="2016-09-07" version="1">MLFEKIKRGGTMKNKLIAAIISICIIGGLGAAIVLGSKVDDSSKLADKKVIQEKSIEDNNSREKDDDKSQENVEVESVEITNDSDVQTAMIENSQPIQNYVEKETEASNDAIENYTEESKQVVESEQNTIEFSEPNIETQTPSYSSDFMSEVESMIFNKVNEERSKNGLAPLSYNSTMERYARIKSQDMGDRGYFDHNNPEGELITAQMQRDGVSYSSWGENIAYIGGVSDAATLANQFMTNWMNSSGHRANILSTNFTSIGVGVYKIGNTVYATQEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNW4</accession>
    <name>A0A173YNW4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0297 protein ERS852471_00270</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0297 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64876">
        <property type="protein sequence ID" value="CUN64876"/>
        <property type="gene ID" value="ERS852471_00270"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939488at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01507">
        <property type="entry name" value="UPF0297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009309">
        <property type="entry name" value="IreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40067">
        <property type="entry name" value="PTHR40067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06135">
        <property type="entry name" value="IreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037258">
        <property type="entry name" value="DUF965_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN64876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="85" mass="9786" checksum="23944CB335B13061" modified="2016-09-07" version="1">MENNLDRTMQFNLGVDKEDLTKSILTDVYKALKEKGYNPVNQLVGYLISGDPSYITSYNGARALLRKLERDEILEEVIKSYLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRT2</accession>
    <name>A0A173YRT2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pstS</name>
        <name evidence="13" type="ORF">ERS852471_00292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263205.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65926">
        <property type="protein sequence ID" value="CUN65926"/>
        <property type="gene ID" value="ERS852471_00292"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7 11" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027165326" description="Phosphate-binding protein" evidence="11">
        <location>
            <begin position="31"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="12">
        <location>
            <begin position="34"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN65926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="29641" checksum="FC7ADFF1815C4C50" modified="2016-09-07" version="1">MKSKKLKLMVGALVVMMMGATLTGCGGNNGQSGDAGTETQTTISISGSTSVGPLMLKVQERYEAANEGITLEVQENGSGAGIKDVINGVSEIGMSSRELKSEEASQVDGTVIAHDGIALLVNPSNKVENITLEQIKGIYTGTITNWKELGGSDSPIVVISREEGSGTRDAFQEIVGYKSEELIKDASIADGSGAVKTTVAGNENAIGFASFEYIDDSVNALKVNDVEATPDNVKAGEYKLSRPFLLVTKKDTLTEAGAALIEYVLSSEGQQIVKDNKLITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YT35</accession>
    <name>A0A173YT35_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rsgA1</name>
        <name evidence="7" type="synonym">rsgA</name>
        <name evidence="10" type="ORF">ERS852471_00317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263253.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67352">
        <property type="protein sequence ID" value="CUN67352"/>
        <property type="gene ID" value="ERS852471_00317"/>
    </dbReference>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="61"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="70"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="161"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN67352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="287" mass="32780" checksum="B0BB27850DED49A2" modified="2016-09-07" version="1">MKGKIIKGIGGFYYVKTSEGLIECKARGKFRHKDMKPMVGDDVEIEVSNGKGVIEDIFERKSQLIRPTVANVTQAFVVFAVKNPDINFDLLNRFLILCEHNNIKAVVCLNKVDLVSEEEKEAIRQRIVDIGYEVLYINAKKGIGVEKLREKLDNNETVLCGPSGAGKSTLINTLTQKFHMETGEVSEKIGRGKHTTRHSELIDVVGGYIVDTPGFSTLEVNFIEKEDLRYSFPEFEEYNNLCKFRGCLHYKEPNCAVKKAVEEGKINKYRYDFYIRTLEEKMDGRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUX1</accession>
    <name>A0A173YUX1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ORF">ERS852471_00308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263235.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66815">
        <property type="protein sequence ID" value="CUN66815"/>
        <property type="gene ID" value="ERS852471_00308"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="187"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="191"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN66815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="43628" checksum="81F47BA89494675A" modified="2016-09-07" version="1">MRDKKRVVIGVTGGIAVYKALDIISALRKQDVEIKVIMTESAQEFVTPLAFQSLSQNMVITDMFAEPKAWEIQHISLAQWADIMLIAPATANIIGKVANGIADDMLSTTIMATEAKVIFAPAMNTKMYENKIVQDNINKLKNYGYKFIEPASGRLACGDLGKGKLANVSDIVDRVLLELEEKEQDLLGKKVLVTAGPTIAPIDPVRYITNKSTGKMGYAIAQEAKERGAEVTLVSGPTNIPRIADINFISVKTNSEMKDAVLRYYDFADIVIKSAAVADYKPKEYSNEKIKKGEGDLQLTLTRDSDILKILGERKKEQILVGFAAESNNVLNNAEKKLKNKNLDFIVANDITASDTGFASEDNKVTILSKDGSVINLDKMSKKQVATNIFDMILGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YX11</accession>
    <name>A0A173YX11_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name evidence="2" type="ORF">ERS852471_00328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263273.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68013">
        <property type="protein sequence ID" value="CUN68013"/>
        <property type="gene ID" value="ERS852471_00328"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547014at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="401" mass="45211" checksum="B1E103DF20BC574E" modified="2016-09-07" version="1">MNITGIITEYNPFHNGHLYHITEAKKATNCDGIVCIMSGNFVQRGGPAIIDKWKRTEMALENGVDLVLELPTFYAVSSAEIFARGAVSILNSLGVVDNLYFGSECGDVDSLYKIAKILTTNNDSFNNMLKNNLKEGISFAKAREKSLIDFSKDDSIKDVISSSNNILGIEYIKAILLEKSKIKPYTLKREGSNYNETNIESTFSSATSIRKALSDNEYSINTLSSVMPEPSYNILKSLKNDGYTFSFDEDLYKFLRYKISTNCVNFNNLYEASEGLDKKILKEVIDSTSYDDLILRVKSKRYTYTKISRLLTQIFIGFDNYNFDKNTISQYNFGRILGFNSKGREILSSIKKTSSIPLITKVPKHPNNPLLELDILATKAYSILNPNLNPKSDYLKNPIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYS2</accession>
    <name>A0A173YYS2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ackA_1</name>
        <name evidence="6" type="synonym">ackA</name>
        <name evidence="8" type="ORF">ERS852471_00330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263277.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68125">
        <property type="protein sequence ID" value="CUN68125"/>
        <property type="gene ID" value="ERS852471_00330"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="399" mass="43597" checksum="1145ABDD61B7A2DC" modified="2016-09-07" version="1">MKVLVINCGSSSLKYQLIDMATEESLAQGLVERIGIEGSVLTQKVEGREKYIVKEAMKDHKDAIRLVLAALVDENNGVISSMEEINAVGHRVVHGGEKYNKSVVINDEVKNYIEECFKLAPLHNPANMIGIKACEELMPNTPMVAVFDTAFHGTMPEEAYLYALPYELYEKHGIRKYGFHGTSHKYVSQKVAEVMGRDIKDLKIITCHLGNGSSVCAVKNGESVETSMGFTPLEGLAMGTRSGSIDPAIVTFLMKEEGLTADEVTDLLNKKSGVLGISGISSDFRDIEDAAYKEKVHRAQLALDIFHYKVRTTIGAYAAAMGGVDAIVFTAGVGENGPETREEILKGLEFLGVKCDTEANKVRGKVREISTADSTVKAFIIPTNEELMIARDTLELISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z1X9</accession>
    <name>A0A173Z1X9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ORF">ERS852471_00358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263322.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69699">
        <property type="protein sequence ID" value="CUN69699"/>
        <property type="gene ID" value="ERS852471_00358"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="29179" checksum="E4C0786DC179ABD4" modified="2016-09-07" version="1">MLKLFKKDKEINEEIQLDFNKIPKHIAIIMDGNGRWAKKRKLPRSMGHKAGVETIRKILKEADRLGVEYMTLYAFSTENWKRPKDEVEALMKLLVQYLTNEVEALHQNGVVLRILGDVDALPDQVKNKIYEAIELTKDNKGIVLNVAFNYGGRDEIVRAVKNIASDIESGKINKENIDEDLFNNYLYTKNSPDPDLIIRPSGEQRISNFLLWQCAYSEFWYSNVNWPDFSESDLQKAIYDYQNRDRRFGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZIY5</accession>
    <name>A0A173ZIY5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_2</name>
        <name evidence="7" type="ORF">ERS852471_00471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75599">
        <property type="protein sequence ID" value="CUN75599"/>
        <property type="gene ID" value="ERS852471_00471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="32575" checksum="8408B85614E0800A" modified="2016-09-07" version="1">MLMNKKKKKKTEELYDTRTKWTPGNIASFIILCMLTIIFIFPFYWIITGSFKDQASTIAVPPQWFPTDFTLKNWISLAKQPLVRWTFNSFFIAISTTVLVCVTSTLAGYVLAKKRFPGRHLIFWALIAAMALPKQVIMVPLFNLLTKLDLINTYRGLILPAVGWPFGIFLMKQFSETIPSELIEASRIDGCTQLGTFRNVVIPIVKPGIGALAIFTFITSWNDYFMQLILIRSTDMQTLPLGIALMQAEFTTNYGLMMAGAAIASIPMIIIFLICQKSFTQGITVGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJ06</accession>
    <name>A0A173ZJ06_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263509.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75145">
        <property type="protein sequence ID" value="CUN75145"/>
        <property type="gene ID" value="ERS852471_00463"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2081709at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="73" mass="8668" checksum="CA308ECF7BD17A76" modified="2016-09-07" version="1">MNNGQERFFNFIMERVSSENQEKAKELLSESFAKQNDGSFNKEYMMSFIPRMLELIKPEFIDEVKNIMSNHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A8K2</accession>
    <name>A0A174A8K2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263689.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83708">
        <property type="protein sequence ID" value="CUN83708"/>
        <property type="gene ID" value="ERS852471_00555"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="18088" checksum="7FFC1B5F89E16EC6" modified="2016-09-07" version="1">MIEVIERFESFTTSVAKAYKCIQKIKLAETKRMGLKPSHVMCMYYLGKNPEGLTATELCKLCIEDKAAVSRTIVELTKKEFVKYSETYPSRKYRTRIILTEEGKEINNQINEAIAKAVTNASKSLDEDERKNFYRVFFYITYNLEMICDSYLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AD66</accession>
    <name>A0A174AD66_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85839">
        <property type="protein sequence ID" value="CUN85839"/>
        <property type="gene ID" value="ERS852471_00584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="121"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="460"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN85839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="591" mass="66060" checksum="58F5AA8AC264EB38" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANA6</accession>
    <name>A0A174ANA6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">thrS_1</name>
        <name evidence="10" type="synonym">thrS</name>
        <name evidence="13" type="ORF">ERS852471_00638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263846.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89399">
        <property type="protein sequence ID" value="CUN89399"/>
        <property type="gene ID" value="ERS852471_00638"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="267"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN89399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="636" mass="73156" checksum="85A5878BE2242211" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AU69</accession>
    <name>A0A174AU69_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205636.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91673">
        <property type="protein sequence ID" value="CUN91673"/>
        <property type="gene ID" value="ERS852471_00670"/>
    </dbReference>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="130"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN91673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="325" mass="36667" checksum="6EBE7CE0BED3BB8F" modified="2016-09-07" version="1">MSKKKKIVICIISFILVVLIGGLGFVGNYFFEYALLRQEGIVTAANVDPNAPQSIETMAEVANKEKAREEVDKWLEDVKTEETTIESEDGLKLWGKMYFQEEQTDKWVIIAHGYTSSHEDIQPIALNFYNQGYNVLTPDMRAHGNSEGKYIGMGWLDRKDILKWIDYVLSIDADSQIVLYGESMGGATVMMTSGEELPSNVKAIVEDCGYTSVKEMFEAQLYERFNLPSFPIINVANIVTEIRAGYDFEEASALEQIKKSKTPMLFTHGGEDTYVPTEMIYRLYDAATCEKDMLVIEGAGHGSAPDVDPETYYEKVFSFLSKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4N9</accession>
    <name>A0A174B4N9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FR47-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263989.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95674">
        <property type="protein sequence ID" value="CUN95674"/>
        <property type="gene ID" value="ERS852471_00709"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1178020at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="28331" checksum="F8B2DC418DD2CF3E" modified="2016-09-07" version="1">MLTKNEILQIAKAQFALDYNFKDYDITKDTNIITENSLISGRRIYDNDGCFLKILCFNGKAFISADPKIIPWCKENLLTIDAAWLSEYPKLKAIDTKLREFGHEIADIHHYYLPKTMNEKIEIHFSIKWYEKEEINQFTNDDRFGEAFAFDKNHPDILAVAAFDGDTMLGMAGASADSDTMWQIGIDVFPEYRGKGIATTLVTLLKNEVLNRGKVPFYGTVETHFISQNVAINSGFFPVWAELYTKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B578</accession>
    <name>A0A174B578_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263966.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94758">
        <property type="protein sequence ID" value="CUN94758"/>
        <property type="gene ID" value="ERS852471_00696"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="22650" checksum="9CC01C9082F8F700" modified="2016-09-07" version="1">MNNLNLRDASECDAPIIAELVYVTEDDPHHEWGEGSKEEILDRIGYLVKVEGSRYYYKNIKVAELDGKPCGVIILLKSDDIPRLDITTSIKLFLSIKGVIRKIKFIKDIILASRLDECGEHEIYVANLATNEEVRGKGIGKSLMILAEKMAKEQGYERCSLLAKDKSLIKFYSKLDYKLEKEERYFSHNLYRMVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BLD3</accession>
    <name>A0A174BLD3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adaA_1</name>
        <name evidence="3" type="ORF">ERS852471_00798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00495">
        <property type="protein sequence ID" value="CUO00495"/>
        <property type="gene ID" value="ERS852471_00798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="28135" checksum="6D93E13DED5BD152" modified="2016-09-07" version="1">MNTYNVLNDFFTCLSLPTLVLNNSFKIVHSHKYNAELKNSFYTSKAIDILKNSLSYSNPIAINIPNNISYSAIAFYHYDNMPAYILIGPYIIQDNKNTKVNTCDSSILTINKSLLDDVINLYSNLIVNKYKTTTPNGTLSPFVKRAIEYIEKNYSKEISIDDLCSELNINKCYFCCVFKNETGQTFINYLNNYKVEKSKELLANTDYSLLDIALSVGFNNQSYYSTVFKKLTNQTPIKYRESLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BU65</accession>
    <name>A0A174BU65_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">proC</name>
        <name evidence="5" type="ORF">ERS852471_00867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264280.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04163">
        <property type="protein sequence ID" value="CUO04163"/>
        <property type="gene ID" value="ERS852471_00867"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO04163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="28515" checksum="A707921BA5161718" modified="2016-09-07" version="1">MSKIIGFIGAGNMGQAILGGIVKAGLVASENIIMSDLYEPSLEKAKGNYNIEITTDNKLVAKKSDILILAVKPNLYPIVINEIKDLVKDDVIIVTIAAGKSIESTEKSFGRELKVIRTMPNTPALVGEGMTAVCPNKLITDNDINEVSKLLNSFSKVEVVGESLIDAVTSVSGSSPAYVYMFIEAMADAAVLQGMPRDKAYKFAAQTVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAVAELEAKGFRSAVISAMNKCYKKSQEMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUB4</accession>
    <name>A0A174BUB4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfcE_1</name>
        <name evidence="5" type="ORF">ERS852471_00851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264252.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03260">
        <property type="protein sequence ID" value="CUO03260"/>
        <property type="gene ID" value="ERS852471_00851"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO03260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="150" mass="17184" checksum="B231DCA68EE8112F" modified="2016-09-07" version="1">MRLGVISDTHGVLRDEVIKNLEGCDYIIHAGDVGGEEIIKRLDKIARTFVVRGNNDGDSWGIKLPYYKEIEMDETLIYVVHKKDDIPSELREVDLVIYGHSHKYSEERIDNIIYLNPGSCGRKRFSLPLTMAIVDINIDRIDIRKIDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BVH1</accession>
    <name>A0A174BVH1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Peptide methionine sulfoxide reductase MsrA</fullName>
                <shortName evidence="9">Protein-methionine-S-oxide reductase</shortName>
                <ecNumber evidence="9">1.8.4.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">Peptide-methionine (S)-S-oxide reductase</fullName>
                <shortName evidence="9">Peptide Met(O) reductase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Peptide methionine sulfoxide reductase MsrB</fullName>
                <ecNumber evidence="8">1.8.4.12</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">Peptide-methionine (R)-S-oxide reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="11" type="primary">msrAB1</name>
        <name evidence="9" type="synonym">msrA</name>
        <name evidence="8" type="synonym">msrB</name>
        <name evidence="11" type="ORF">ERS852471_00858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="9"/>
    <dbReference type="EC" id="1.8.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264266.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03650">
        <property type="protein sequence ID" value="CUO03650"/>
        <property type="gene ID" value="ERS852471_00858"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="10">
        <location>
            <begin position="180"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO03650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="318" mass="36622" checksum="5C8C37686095AB42" modified="2016-09-07" version="1">MSNIKKAIFAGGCFWCMVKPFDKYDGVSSVIVGYTGGNIENPTYEQVCNMKTGHYEAVEITYDEEKVSYKELLEAFFKSIDPTDDGGQFYDRGDSYKTAIFYQDENQKRIAEDYIKEIDNSKRFDNPVVTKILKSEKFYPAEDYHQDYYKKNPFKYNVYYKGSGRKEFVESAWKKSEEEKLALKDKLTDIQYRVTQLNATEAPYNNEYNDNYEEGIYVDVVDGKPLFSSKDKFNSGCGWPAFSKPINGGYIKEIEDLSHGMIRTEVRSTNADSHLGHVFNDGPTEFGGLRYCINSASLKFIPKCDMEKEGYGKYLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZD9</accession>
    <name>A0A174BZD9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264322.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06194">
        <property type="protein sequence ID" value="CUO06194"/>
        <property type="gene ID" value="ERS852471_00879"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="208" mass="24348" checksum="047FC7D3C9D2E1B0" modified="2016-09-07" version="1">MFNKDNIFITVNEEVSSIIQQYVIREIKKVLDKYKSITTEEISSVEKLINSISNEELKEEFLNDWSMSVKIAKEIGENEVDDRIISMYQNLKGNGLEELSIDYVINWCNELEEQGYVMINDYSIIYKSSANLRDIARELLDDMLDDAIYVDALIDKDSLVEYWIEQTSKEDVIDDLIRGNNIEELLGLVPETIYEDEYNKYLYSEIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2B9</accession>
    <name>A0A174C2B9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.99.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gfo</name>
        <name evidence="2" type="ORF">ERS852471_00897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.99.28" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264356.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07103">
        <property type="protein sequence ID" value="CUO07103"/>
        <property type="gene ID" value="ERS852471_00897"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047061">
        <property type="term" value="F:glucose-fructose oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO07103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="328" mass="37191" checksum="F6E5DC0870DB16E8" modified="2016-09-07" version="1">MIRFGIVGTNNITTWFLDGASLVKDFKLTAVYSRTEEKAKEFANRYGVQNTFTSLEDMAKSDLIDAVYIASPNRLHAEQAILFMNNGKHVLGEKAFASNTKEVNKMIEAAKKNNVVLMEAMKTTLMPNFKVAMENIHKIGKVRRYFASFCQYSSRYDKYKEGIVLNAFNPELSNGALMDIGVYTIAPMVALFGRPNEIKASSYMLESGADGEGTIIFKYDDKEASVIYSKISNSHLPTEIQGEEGTMIIDRINTMGSVKIIYRDGNVEDLTQYQEEHNMCYEIEEFINIIQRGEKESKINSLEFSKNVMEIMDEARRQIGLVYPADRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6Q4</accession>
    <name>A0A174C6Q4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ansB</name>
        <name evidence="4" type="ORF">ERS852471_00903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264368.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07438">
        <property type="protein sequence ID" value="CUO07438"/>
        <property type="gene ID" value="ERS852471_00903"/>
    </dbReference>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="13"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="3">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="460" mass="49994" checksum="35F8E23CD1332401" modified="2016-09-07" version="1">MDFRVERDSIGTKEIVKDAYYGVQSLRGYENFRITGLNVDERFVKDLAIVKKACAIANMKAGELKEELANAIVTACDEVIAGQFIDQFIIDPIQGGAGTSLNMNMNELIANRANEILGHSKGEYYPIHPNDHVNMGQSTNDVIPTAGSITAYKYLVKCVDNLKALEIAFSEKAREFADIVKMGRTEMQDAVPISLGAEFKAFSRAIGRDVKRIDAVKEELLGVNLGGTAVGTGITASRKYMDTVVDELSNVSGLNVYQVEDLIDGTQNLDKYSEVSSQLKTCAVNISKIAGDLILMSSGPRTGFGEIKLPSKQNGSSIMPGKVNPVLPEVMKQIAFQIMGNDLTISMAVQSGQLELNAFYPVLIYNLYQSINILSNGVDTFINNCVLGIEPNVKRCKELVEGSIGIVTALAPVLGYEKAAAIAKKALYTGKQVKEVAEEESELSSSEIVSLLNVEKMLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9W0</accession>
    <name>A0A174C9W0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08528">
        <property type="protein sequence ID" value="CUO08528"/>
        <property type="gene ID" value="ERS852471_00923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="77" mass="8719" checksum="274ED066715A93DA" modified="2016-09-07" version="1">MNKHKMKRILLGVYLMIISSIFISCTAIYKNNINDITAKGDEELEGTIRFVSNRTDKKAELEALISDFEEMHPGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBL8</accession>
    <name>A0A174CBL8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid kinase</fullName>
            <ecNumber evidence="3">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dagK</name>
        <name evidence="3" type="ORF">ERS852471_00964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264485.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10574">
        <property type="protein sequence ID" value="CUO10574"/>
        <property type="gene ID" value="ERS852471_00964"/>
    </dbReference>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO10574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="32626" checksum="6D8266CF9BD80DCE" modified="2016-09-07" version="1">MRYVKFIYNPYSGENLILSKLDKVISIHQDAGYTIVPYRISRDEDVSEAFKDVKDFDYKYVLVAGGDGTVDSVVNAMAKQGISIPIAILPVGTANDFAKFLGIPSDIEEACNRIINSHITTVDLGSINDKYFVNVASTGLFTDVSQKTDVNIKNTIGKLAYYLKGLEELPNFRKLKVKINSENVNFEGEMYFLLVFNGQTAGNFKLATKSDAKDGLLDVIIFKAIPIMELIPLFIKVLKGEHLDSENVIYFKSKEIHIECYEDIVTDIDGEKGPDFPLDIKCIKGGLKILGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CG15</accession>
    <name>A0A174CG15_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK_2</name>
        <name evidence="13" type="ORF">ERS852471_00960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264479.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10436">
        <property type="protein sequence ID" value="CUO10436"/>
        <property type="gene ID" value="ERS852471_00960"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="8"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="175"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO10436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="32166" checksum="99B75E4C35FBDCD1" modified="2016-09-07" version="1">MIYNSMLDLIGKTPILKLNNMVGENSADVYVKLEKFNPGGSVKDRAALGMIEKAEELGILKEGSTIIEPTSGNTGIAIAMIGRVKGYKVIIVMPETMSKERRDLIKAYGAELILTEGAKGMKGAIAKATELVDNYGYFMPQQFENIANPNKHYETTADEILEDIKDLDAFVAGVGTGGTITGVAKKLKENIKTLKVVAVEPEKSQVLAGKGPGAHKIQGIGAGFIPSIYKGEYVDEIIPVSDQDAINTAVEFARKEGILIGISSGAALFAALQVAKKLGKGKKVLAIAPDGGEKYISMGIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJI5</accession>
    <name>A0A174CJI5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdaAA</name>
        <name evidence="3" type="ORF">ERS852471_00996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12120">
        <property type="protein sequence ID" value="CUO12120"/>
        <property type="gene ID" value="ERS852471_00996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004642">
        <property type="entry name" value="Ser_deHydtase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00718">
        <property type="entry name" value="sda_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="30426" checksum="B9F4A6211664E16D" modified="2016-09-07" version="1">MIVARSGEELLKICEEENISLSEYAIRLEMEDKGLTREQVFEKMAKNLEVMREGANEGREKKIYSVSGLIGGDGYKINKYLRKGNTLTGDVTVRAMAMALSSSEVNAAMGRIVACPTAGSCGILPAVILSAGEKLEKTDEELIEGLFAAAAVGMIIGMNATLAGAEGGCQAECGSAAAMGSAAVVEMMGGTPKMSLDAGAIVLKNVLGLVCDPVAGLVEIPCAKRNAAGAISALCTADMVMAGVDSKIPFDDTVSAMYKVGKSLPSELRETAMGGVAVTKAGLELRKKVFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CRR7</accession>
    <name>A0A174CRR7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rebM</name>
        <name evidence="2" type="ORF">ERS852471_01048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264583.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16251">
        <property type="protein sequence ID" value="CUO16251"/>
        <property type="gene ID" value="ERS852471_01048"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29674" checksum="0FF36CF738A27E2E" modified="2016-09-07" version="1">MSNLLNDIEKYWTNRADGYSSVNKGELATVQKDKWLDEIEKNLNELSNKPKENIKVLDIGCGPGFFSIILARAGYKVTAVDYTSKMIEKAKENCGDIADKITFIKMDAQNLKFDDESFDVVISRNLTWNLEKPDMAYKEWIRVLKKNGILLNFDANWYHHLFDDEKRKEYEEDRNRVANSNLEDHYTCTDIESMEEIAKKVPLSRIIRPQWDILTLNKLGVTSVNVDLDIWKSLWSEEEKANYASTPMFLVKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CTW1</accession>
    <name>A0A174CTW1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marR_1</name>
        <name evidence="2" type="ORF">ERS852471_01063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264596.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16941">
        <property type="protein sequence ID" value="CUO16941"/>
        <property type="gene ID" value="ERS852471_01063"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="148" mass="17503" checksum="238FBC0C7A0929BC" modified="2016-09-07" version="1">MKKCKRRNDIGLLIKLVDNRIKKAINKNLIRFNLTATQEKVMWSIFRMQEHSKDVFQKDIERELDLSNPTVTGILKRLEEKEMIKRIPSSEDARYKCLTLTDKGLDVIHECMDFGVNYIEKKLTKDMTEEELNTLRTLLNKVIDNMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVT8</accession>
    <name>A0A174CVT8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta superfamily hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264578.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15940">
        <property type="protein sequence ID" value="CUO15940"/>
        <property type="gene ID" value="ERS852471_01043"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="30867" checksum="38FF09D9673FD9DE" modified="2016-09-07" version="1">MGYYVGVSGNTKIYVEDINIECKDVIVFLHGWPGNHNLFEYQFDYFSQKGYRCIGLDQRGFGKSDKPSYGYDYNTLADDVKSVVDQLKLKDFTLVGHSTGGAIAIRYMARHNGCGVSKLVLCAAAAPSLIKRPDFPYGLDKSAVDNIIMGTYMDRPKMLEDFGKSFFYRKVSRPFSEWFLQLGFQAAGWATAAVARTWINECLFEDMKEINVPTLIMHGIHDKVILPPLGEVQNKLIKNSKLVKFKKSGHGLFYDEKDKFNEELMGFVEKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZN2</accession>
    <name>A0A174CZN2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron only hydrogenase large subunit, C-terminal domain protein</fullName>
            <ecNumber evidence="2">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.12.7.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264614.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18507">
        <property type="protein sequence ID" value="CUO18507"/>
        <property type="gene ID" value="ERS852471_01092"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="449" mass="49545" checksum="F47A15C17A4D041E" modified="2016-09-07" version="1">MNSKYSDLFDDLVKSYYTGNFDETLNMIMTCHDKSPQETFKIITSLCGVDIPFDNNFVYNLKKAITNYAVNKRIVSKLEECTTNCTQDENHKFRCQATCPFDAIKYDDKKHTTYIDQNTCVECGLCVDACKDGKILDRVEFIPIKDLINHNKTVVAAVAPSIIGQFGPNVTMDQLRAALMKVGFTDMLEVAFAADMLTIKEAVEFNKHVNGPNDLMITSCCCPMWVGMLKKVYKELVPDLSPSVSPMVAAGRVIKKLNKDAKVVFIGPCIAKKAEAKEKDIAGAIDFVLTYQELDSIFQILDIHPEELQGIPSVEYASKGGRLYGRAGGVSVAINEMVEELYPNKSEHLKAVKADGVKACKELLDKAMKGEIDGNFIEGMGCIGGCVGGPKVLIPKEEGTMATNNFAFYSPIKIAAHSSTLDDVLGELGINSLKDFEDDDKISILHRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0P5</accession>
    <name>A0A174D0P5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulator YdeP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydeP</name>
        <name evidence="2" type="ORF">ERS852471_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264625.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19114">
        <property type="protein sequence ID" value="CUO19114"/>
        <property type="gene ID" value="ERS852471_01105"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="108" mass="12255" checksum="D5AD385F29AE243B" modified="2016-09-07" version="1">MNKNLPPCPVEVTLSLIGDRWKVLIIRDLLEGTKRFGELKKSLGTITQKVLTSNLRAMENSGLLTRKVYAEVPPRVEYTLTETGYSLKPILDSMVEWGENYKKICEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DD25</accession>
    <name>A0A174DD25_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">ERS852471_01163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264677.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21950">
        <property type="protein sequence ID" value="CUO21950"/>
        <property type="gene ID" value="ERS852471_01163"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO21950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="21779" checksum="47EA2E9742C7A36D" modified="2016-09-07" version="1">MDKEHEANLSYTICYALRHEPWRFNLELDENGFCEVNDLLNSLKLYYDDITILDIKYVVENDPKGRFELIENKIRAVYGHSFERKIIYNEIIPPDILYHGTTLEVYNEFISKEGLKHQKRQYVHLSSTVETAIMVARRRKNKTHIVLEINAREAYKDGVKFYKASDDIYLSNDIPAIYLKIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DDI7</accession>
    <name>A0A174DDI7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cspL</name>
        <name evidence="5" type="ORF">ERS852471_01199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264710.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23554">
        <property type="protein sequence ID" value="CUO23554"/>
        <property type="gene ID" value="ERS852471_01199"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="4">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO23554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="69" mass="7633" checksum="7702E9783CE3DB8A" modified="2016-09-07" version="1">MSSYTGTVKWFNQEKGYGFISANDGQDVFVHHSQVKEKGTDKDLHEGENVSFSIGEGEKGPMAINVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEG4</accession>
    <name>A0A174DEG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent glutamate synthase</fullName>
            <ecNumber evidence="2">1.4.1.13</ecNumber>
            <ecNumber evidence="2">1.4.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltD_3</name>
        <name evidence="2" type="ORF">ERS852471_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.13" evidence="2"/>
    <dbReference type="EC" id="1.4.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264711.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23597">
        <property type="protein sequence ID" value="CUO23597"/>
        <property type="gene ID" value="ERS852471_01200"/>
    </dbReference>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO23597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="411" mass="45212" checksum="C1E1552A4BC3CEB9" modified="2016-09-07" version="1">MSSHVLEEARKCLGCKKPRCTAACPVSTEIPEVIRLLLSGDIDSAGEKLFNNNPLSVICSLVCPHEKQCEGNCVLNAKNNPVHFGDVENYISDFYIHKAFTKSKIDKEKRVAIIGSGPAGITISILLAQKGYNVTIFEAHDKIGGVLRYGIPEFRLSRDILDNIKEKLVEMGVKIRPNTMIGPYITIDDLFRDGYKAIFIGTGVWNPRTLNVKGETLGHVHYGIDYLKNPDVYDLGDRVTIIGAGNAAMDVARTAIRKGAKEVYVMYRKGEIDAPAEKLEVEYAKLDGVKFLYYKNPLEILDEGIRYTETKEVFDDEGNRSVIEDKGKEGVFNTNSVIIAVSQGPRSNIVSTTKGINTLPSGLVHVDEYGRTSRDGVFASGDVVTGAKTVVEAVRLSKKVAEAIEEYVTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFZ8</accession>
    <name>A0A174DFZ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit DhaL</fullName>
            <ecNumber evidence="2">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaL</name>
        <name evidence="2" type="ORF">ERS852471_01186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264699.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22940">
        <property type="protein sequence ID" value="CUO22940"/>
        <property type="gene ID" value="ERS852471_01186"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1689902at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="23627" checksum="E0374D12EA1431A2" modified="2016-09-07" version="1">MGLTLKEVLYTFEKIEKKITYYKQFLNELDAIIGDGDHGTNLSKGFKVAKEKVKDKEFKDWGDIFRTVGMAILSNVGGASGPLYGTAFMKASMIGKEKVEINIEDFRDILKVSIDGIKMRGKSEKGDKTMLDALIPAYEEINYGIENKLSVLNTLKNSVEAARNGVEYTKFIVASKGRALYLGDKSIGHQDPGATSSLIILEVIFDTVNELRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DG80</accession>
    <name>A0A174DG80_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23075">
        <property type="protein sequence ID" value="CUO23075"/>
        <property type="gene ID" value="ERS852471_01188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="25"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="36137" checksum="268DC5EDCA029E07" modified="2016-09-07" version="1">MFYCINSFFYGNVITIDLIDRGRLMKRFKKVYIETTNICNLSCNFCPKTSRELRFMEVDSFKKIIDDVKQYSDYVYFHLMGEPFLNKNLEEFLEICKEAELKVNITTNGTLINNVKGILLKSKALRQVNISLHSFEANDSKVTLEEYITNITSFINEANENSNIICSIRLWNMDTEELKACNSLNSNILRILEEELNIEFSLGERLQEKSGIKVRKNLYVNMAEKFEWPNINLVNEEAEVFCYGLRDQIGILVDGTVVPCCLDSEGNIPLGNIFKTPLGDIITSKRALDIYDGFSNRKAVEELCKRCGYAKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQH9</accession>
    <name>A0A174DQH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="12">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dacB_1</name>
        <name evidence="12" type="ORF">ERS852471_01258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264801.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27733">
        <property type="protein sequence ID" value="CUO27733"/>
        <property type="gene ID" value="ERS852471_01258"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1499212at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020164" evidence="10">
        <location>
            <begin position="30"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO27733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="428" mass="46500" checksum="12466872913376FF" modified="2016-09-07" version="1">MTKRFFKGMVLLLCLTLILPFIGNIEAFASELQAPEIIGASSITMDIDTGEVIYSKNADMKRSPASTTKLLTSLLFAENKNKGDLISYTETSASLTETTLSGFIAGGVKPGDTMTADDVMKAVMIFSANDASVLMAESVAGSIEAFSKMMNEKAKELGALNSNFVSPNGLEDPTNPNNNNSTTAYDLALIGIAAYKNDWIRETMTLEDTPVYLNGGRIDLETRNKNLNKDGNVGGKTGTETLAGHCFVGFYNRDGRNLVTVVLGSDYGSDGTNVFNDTKAVADYSYEVSKVPYKTTGEEIGNVDLSYKLFKFFGPTKTITAPVILAQDVEYYKNDFNDTNANLSLSNTNADAWKVASNNSVDLTFSIGHFTETVKGTIALTTGQIFKANLPVYAAVIIGTIIAIVLIVIIVNLIRKSSRKNRRNRYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQY2</accession>
    <name>A0A174DQY2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="7">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP cyclohydrolase I</fullName>
            <shortName evidence="7">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">folE</name>
        <name evidence="9" type="ORF">ERS852471_01236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264759.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26658">
        <property type="protein sequence ID" value="CUO26658"/>
        <property type="gene ID" value="ERS852471_01236"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1632367at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="8">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO26658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="20675" checksum="90EF241443A03AB7" modified="2016-09-07" version="1">MDREKILEGARLILEGIGEDVNREGLLETPDRIARMYEEIFGGLGKDAKEILSKTFEVDNDDLVIEKDITFFSMCEHHLVPFYGKAHIAYIPNGRVAGLSKLARTVELYSKKPQLQERLTSEIADAIMDNLNAKGAMVVIEGEHMCMTMRGVKKPGAKTITTTYRGVFKEDLNLRKETLGLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYB4</accession>
    <name>A0A174DYB4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapF</name>
        <name evidence="10" type="ORF">ERS852471_01320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30493">
        <property type="protein sequence ID" value="CUO30493"/>
        <property type="gene ID" value="ERS852471_01320"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO30493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="30548" checksum="1DDAA3ED93C6AD4B" modified="2016-09-07" version="1">MIKFQKFHGTGNDFIILKERDLNFEDYSELAKKVCNRHYGIGADGMIIVSESTKADIRMKFYNADGSIASMCGNGIRCFSKFVYENGIVKGKNFNVETLAGIMKPEVIVEDGKVNFVKVNLGKPIFVSSEIPVSNGNKYFINEEISVDGSCFKISSLVVGTIHTVLFVDDFNDLDIKAVGRAIEYNDIFPIKTNVNFCKVIDHKNIEVITWEKGVGITLACGTGAASSAVISSILKGCDKKINVKVLGGNLIIEQKDDEIFMTGPAEFICSGEYNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYW6</accession>
    <name>A0A174DYW6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ORF">ERS852471_01318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264907.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30407">
        <property type="protein sequence ID" value="CUO30407"/>
        <property type="gene ID" value="ERS852471_01318"/>
    </dbReference>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="37"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="41"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="433" mass="49025" checksum="992E975FA01B5A12" modified="2016-09-07" version="1">MNLFGTMKKNQNGNLEIGNCDVVYLAKEYGTPLYVVDEELVRRNCRVFNDNFKGKGIKTEVIYASKAFLNLAICKVIEEEGLSLDVVSGGELYTAIRSKFPLSRVYMHGNNKTEEELRLAIESGIGRIVVDNRDELDLIEYLCNELDKKIEVLLRVNPGVDAHTHEYIQTSKNDSKFGESIFSEDIYEVVRKFMNSERVTLRGFHCHIGSQIFQETSFYMSVSVMVDFISKIKEKCDFITRELNMGGGFGVYYSDGDVPIELSNFLNNMVISIKEECEKHNLLIPKIMIEPGRSIIANAGTTLYKVGGTKKTYGDKNYIFVDGGMTDNIRTALYDAKYEAVVANKFDNKEKIEYTIAGKCCESGDIIVKDIMLPKVERNDILAVLSTGAYNYSMASNYNRIPRPAVVFVRDGIARIAVKRESYEDILKNDVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E437</accession>
    <name>A0A174E437_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD linked oxidase domain-containing protein</fullName>
            <ecNumber evidence="5">1.21.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvdP_1</name>
        <name evidence="5" type="ORF">ERS852471_01337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.21.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264941.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31199">
        <property type="protein sequence ID" value="CUO31199"/>
        <property type="gene ID" value="ERS852471_01337"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO31199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="450" mass="51416" checksum="7B90B76E686CB522" modified="2016-09-07" version="1">MYNYDYSMLTGDVITKDDFEYEESRKCWNRAIEKYPYIINYCNNKEDVSNAIKWARKNEISFRIRSGCHNYEGFSTGNDLLVIDVSKINSICIDEDRGYVKLGGGVRNREIYEALGNKGYPFPGGGCPTVGVSGLILGGGWGYSTRLFGLSCDTLIELELVNYNGEILTVNEKENEDLFWACRGAGGGNFGVVISMKFALPKKIEMATLINGDFNNCDIDEAVELISTWQEMYKNLDKRFNGKLSIYNSKENGKGVKFTALLYGDKKEANEILEPLKKASTNLLLKMEYGTVLEANRKIQDSHPDYESYKSSGRFVYKEYSKNEIKELINLIEDRAEGAIYTAITFYGLGGAVLDFKNDKTAFNYRDAKFIMGFQSVWEEAKYAPLNKRWFLDKFSYIKNITKGSFINFPLLELENYKEEYFGENLSKLKKIKSKYDPLNIFKFPQGIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJZ3</accession>
    <name>A0A174EJZ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265136.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37068">
        <property type="protein sequence ID" value="CUO37068"/>
        <property type="gene ID" value="ERS852471_01449"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1969696at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="73" mass="7916" checksum="E107CC812E257BAE" modified="2016-09-07" version="1">MENNNLNQEILDKITKVCVCKAISRATIKDVIAKGAHTVDDVVKVTGACTGGCKGFRCKDKIQTLINDHLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKN7</accession>
    <name>A0A174EKN7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265115.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36510">
        <property type="protein sequence ID" value="CUO36510"/>
        <property type="gene ID" value="ERS852471_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="12442" checksum="371AB45C313D5664" modified="2016-09-07" version="1">MDDSNMLNDESLDKLGYIKELDIFSIVDKQFDKKRERKRVKRAIFISILIVVFVSLITCLAIIMPRIAVIDKRIMNIPKLIIGYYFVSVSMMMLLIIPIIKRKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKS2</accession>
    <name>A0A174EKS2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigY</name>
        <name evidence="4" type="ORF">ERS852471_01436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265117.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36570">
        <property type="protein sequence ID" value="CUO36570"/>
        <property type="gene ID" value="ERS852471_01436"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="176" mass="20728" checksum="EC9A22BDBDD9E030" modified="2016-09-07" version="1">MEEIELIKKAQDGNKHAMNILLQNNYKALYGFTLKMTANEDLTQDIVQEVCLKAVVNINKFKGKSKFQSWLISISINYYRDIIRKNKKIDYSCEIELSHIENNETDTILDRLQVEEMLKELKKMPYEKRISFILKHYYGYSYEEISKVFKCSEGTVKSRVFYTASRLKKKLVGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F996</accession>
    <name>A0A174F996_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wcaJ_4</name>
        <name evidence="9" type="ORF">ERS852471_01623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265471.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46694">
        <property type="protein sequence ID" value="CUO46694"/>
        <property type="gene ID" value="ERS852471_01623"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="25266" checksum="B440A77D20DF6087" modified="2016-09-07" version="1">MAELQYNIGDSNVVVEERKGYEFLKRCIDIGGSLCGLVLLSPILLIIMALIKLESKGPVIFSQERVGRYGKTFKMYKFRSMVMNAEELKKKLQAQNEMSGPMFKMKDDPRVTKSGKFIRKTSLDEIPQLVNVLKGDMSLVGPRPSLPQEVEQFEAWMYRRHDVKPGLTCYWQVSGRNNIDFEDWMKLDVKYVEERSFWIDIKLIFKTVFVLFGDKNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDZ8</accession>
    <name>A0A174FDZ8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmA</name>
        <name evidence="6" type="ORF">ERS852471_01640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265503.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48373">
        <property type="protein sequence ID" value="CUO48373"/>
        <property type="gene ID" value="ERS852471_01640"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO48373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="99" mass="10841" checksum="2CD8C62EE85BDFF1" modified="2016-09-07" version="1">MMIMNLQLFAHKKGVGSSKNGRDSEAKRLGVKAADGEFVLAGNILVRQRGTKIHPGVNVGKGGDDTLFAKEDGIVRFERMGRDKKKVSIYPVEVQEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQ36</accession>
    <name>A0A174FQ36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50739">
        <property type="protein sequence ID" value="CUO50739"/>
        <property type="gene ID" value="ERS852471_01688"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2209913at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="110" mass="12622" checksum="EC53A5E87A60E76A" modified="2016-09-07" version="1">MPQFINKFMYILLILFITFLVLNEFYVIDFSTNLKNIFIFLTLILILLTSMKEILSGTNGFIKFLNVMTLLCTIIGGIFSIIKGQLNTFIYICLIFSLINGVIVLTYSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FT10</accession>
    <name>A0A174FT10_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat protein CotS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cotI_1</name>
        <name evidence="1" type="ORF">ERS852471_01743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265685.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53353">
        <property type="protein sequence ID" value="CUO53353"/>
        <property type="gene ID" value="ERS852471_01743"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="333" mass="39650" checksum="00F8DD491740986F" modified="2016-09-07" version="1">MMREFEVERQFGIKIDNIKANKGVYYLKTNKGERCLKKINYGPQKLLFVYGAKEHLIKNGFKNVDRYFLNIDGEPYALVNEDLYTLSEWLEGRECDFHNIEDVKIAARTLAKLHEASKGYDPPENSKLKTDLGRWPTLMAKRVKSLDKMRDMVRKKNNKSSFDLLYIKSLDFYKKIGKEALKTLEESEYEALCAVAENEKGFCHHDYTYHNIIIGQDNEISVIDFDYCKREIRTFDISNFMTKVLKRCNWNIDFATAIIDSYNEESPLKEEEYKVLFAYLQFPQRYWRLANRYYYNEVNWGQNTFASKLEGIINEQEEYLKFLEQFKNNYDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTA9</accession>
    <name>A0A174FTA9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA (5-methyl aminomethyl-2-thiouridylate)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.61</ecNumber>
            <ecNumber evidence="4">2.8.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mnmA_2</name>
        <name evidence="4" type="ORF">ERS852471_01735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.61" evidence="4"/>
    <dbReference type="EC" id="2.8.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52961">
        <property type="protein sequence ID" value="CUO52961"/>
        <property type="gene ID" value="ERS852471_01735"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1230735at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004808">
        <property type="term" value="F:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO52961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="329" mass="37235" checksum="B719FE7864778D80" modified="2016-09-07" version="1">MTKALAMISGGLDSILAAKLIKEQGIEVIGICFRSYFFSEESAKKMTKQIDIPLVVVDFSNEHLDMVKNPKHGRGKNMNPCIDCHAMMMNYAGKLLEEYKADFIITGEVLNQRPMSQNRQALNIVKKESGFANKILRPLCAKNLDPTEMELSGLVDREKLLDISGRSRKAQMELAEKWGITEYPSPAGGCKLTEPNYALRLKDLLDYKNEVEEDELSLLRYGRHFRTKDNNKIIVARTKDEGDMIKNHIDGSYYSFHTSDFSGALVLLQGEGTEEDRKLAARISGRYSKGRTEKVLKVKFGKYGSKFNSEIEVEPISDEELQEYIVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUX7</accession>
    <name>A0A174FUX7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">atpG</name>
        <name evidence="10" type="ORF">ERS852471_01712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265629.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51905">
        <property type="protein sequence ID" value="CUO51905"/>
        <property type="gene ID" value="ERS852471_01712"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO51905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="281" mass="32024" checksum="09409B7824933346" modified="2016-09-07" version="1">MGTSGLVEIKRRIQSIQSTKKITKAMGFVATSKLKKVKNRLTDNNEYVKVIEEIVQELVNSLPDDYESIYINRIKGKKLYIVITSDAGLCGGFNNNVVSYFREVIEDKEESEIILIGKKGISYFDKFKLKSNKHIIDMPDVPTNKEVNELYNIINEAYRNGEITEVNIVCTIFKSPINQVPKVIKLLPIEKKDNQQDKYIIEPNIDSVFNNAMNLYIKSKLMECLLQSRVSEESARKMAMDGATDNATEMLRTLNIKFNRIRQSIITQEISEIVGGAEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV60</accession>
    <name>A0A174FV60_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rho</name>
        <name evidence="11" type="ORF">ERS852471_01731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265661.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52748">
        <property type="protein sequence ID" value="CUO52748"/>
        <property type="gene ID" value="ERS852471_01731"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="212"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="224"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO52748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="468" mass="53147" checksum="D34CBBA2C68C7CEF" modified="2016-09-07" version="1">MTRENYEKMTLAELKEIAKNLGIKNISKLKKLELVDEIIKISPNRIEKDGVVLVEKIAPKLKAVNQEVDITQEQVNEENREEKKERLKVMINESGSAKGVLEVQENNNFGFLRCDNYQTGENDIYVSPSQIRRFNLKTGDEVQGKVREAKEGEKFKALLFVEKVNGEDPNKAIGRKAFETLTPIYPNERLHLESKDRNDLSSRLMDIICPIGKGQRGIIVAPPKAGKTTLLKKVAQNISRNYPDVKLIVLLIDERPEEVTDMKRSIDGDVIYSTFDEEPQNHIKVSRMVLERAKRMVEQGKDVVILLDSITRLSRAYNLTITPTGRTLSGGLDPGALIMPKKFFGAARNIEEGGSLTILATALVETGSRMDDMIFEEFKGTGNMEVHLDRKLQERRIFPAIDIYKSGTRKEDLLLSEAEKEVAFAIRRVMYRDGNIETITENLINMLSKTKDNEEFISVFPKSDVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEJ4</accession>
    <name>A0A174GEJ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsQ</name>
        <name evidence="8" type="ORF">ERS852471_01847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265887.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59259">
        <property type="protein sequence ID" value="CUO59259"/>
        <property type="gene ID" value="ERS852471_01847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO59259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="29392" checksum="6C191882CE19DC69" modified="2016-09-07" version="1">MTEYKQSNEIKKYLKSKKRKKKLKKMIMIMIVLTIAILLFLTKAPIFNIKTIDVIGTSKISSDNLKENLKVFIGENIYIINENDIKSALMQDKYVKEVKISRKGISKLVINIVEESPVFYVENNGVIEVINEDLVVIEEIDSIEGRNLVKISGIESEKISLGEKINDDEILPSILKKFYPYIAQNRESIKFDEINIADIVNIKGRIGNVEIFFGDDSDLHEKMENVYRILLSDEIKLTKGYIDVSFDGPPIIKNISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKQ5</accession>
    <name>A0A174GKQ5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265975.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61479">
        <property type="protein sequence ID" value="CUO61479"/>
        <property type="gene ID" value="ERS852471_01900"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2005633at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025374">
        <property type="entry name" value="DUF4364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14277">
        <property type="entry name" value="DUF4364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="177" mass="20581" checksum="156A2F3C70C5CFC4" modified="2016-09-07" version="1">MYENSAELAENKLLVLYVIKSLKHPISNTQLTEIILENNFINYFTLQQYITELLSSEFLKYIEKNDKKLLTITTKGEKVLSFFTQRISPIKRDIIDNYISSVIDNIKKELTIYSDYTIENSDSFIVNLKALEDEMLLIDLKVSVPTKSQAKALCSKWKDNPSDIYTRIMQSLFSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZR3</accession>
    <name>A0A174GZR3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmuC_5</name>
        <name evidence="11" type="ORF">ERS852471_02015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266201.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67491">
        <property type="protein sequence ID" value="CUO67491"/>
        <property type="gene ID" value="ERS852471_02015"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="10"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO67491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="432" mass="46837" checksum="FABFC8419881FD1E" modified="2016-09-07" version="1">MKQGAFSKFMEKFLMPIAQKIEGQKHLQAIKDGIIAVIPIIIIGSFSLIPIGVANLFPNSAFYNFVNTYINYFNLAGFFTTNLMSLYAAFFIADSLQKKYNLNSSLIGITSVVCHLVLSVSIEDFANSTIWNVSSLGAEGLFVSMIVSIVVVEISRLCKEKKLVIKMPDSVPPMVAESFTILIPLVINFALAVAGSIICMNVAGVTFPQLIMKLLAPAITSMDSLPAVMLVIFLTQLLWFFGLHGASITSSVWAAFAISYGAANAAAVAAGQAPQHVFTFGFYYGFLQVTGSGITLGLVFLMMRSKAKSLKAIGKLGIIPSFFGINEPVIFGAPLIMNPFMFIPFVFGPVIVAGLNYLAMSTGLVGLPLYEAPGFLPPGFQAFLLTLDWKAFALAIFNVIFMTAVYYPFFKAMEKDELRKEAIAEGNVNVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3X3</accession>
    <name>A0A174H3X3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266232.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68036">
        <property type="protein sequence ID" value="CUO68036"/>
        <property type="gene ID" value="ERS852471_02030"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1684141at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010841">
        <property type="entry name" value="EF-G-binding_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038344">
        <property type="entry name" value="EF-G_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07299">
        <property type="entry name" value="EF-G-binding_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-G-binding_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FBP_C" evidence="2">
        <location>
            <begin position="97"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO68036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="217" mass="24935" checksum="3D63C9684033D745" modified="2016-09-07" version="1">MNEFIKKQEYNYIKRCMGDLNSGLRNCVDKNVVDAIRICCQDKILSHFNDLSDEQKKVLDISNITDPLLIEPYLKELNQYVYGMPKLSSAEVIKVFKKEKKLKLPNLNIEESKLVYLGWIDESTRKLLITYKLDGKLFGMACRLPKTSNKGTNICALCNHIGSESEVAFVSPICKQTSEDDYKSLGFYVCLDSNECNERIESVEKLEELIKTVNRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9Z4</accession>
    <name>A0A174H9Z4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase III PolC-type</fullName>
            <shortName evidence="11">PolIII</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">polC_2</name>
        <name evidence="11" type="synonym">polC</name>
        <name evidence="15" type="ORF">ERS852471_02073</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266300.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69665">
        <property type="protein sequence ID" value="CUO69665"/>
        <property type="gene ID" value="ERS852471_02073"/>
    </dbReference>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024754">
        <property type="entry name" value="DNA_PolC-like_N_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028112">
        <property type="entry name" value="DNA_PolC-type_N_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14480">
        <property type="entry name" value="DNA_pol3_a_NI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11490">
        <property type="entry name" value="DNA_pol3_a_NII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01405">
        <property type="entry name" value="polC_Gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="14">
        <location>
            <begin position="348"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="13">
        <location>
            <begin position="434"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO69665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1459" mass="165259" checksum="3BBB28B7EDA122E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE63</accession>
    <name>A0A174HE63_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yycG_3</name>
        <name evidence="8" type="ORF">ERS852471_02104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266360.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71309">
        <property type="protein sequence ID" value="CUO71309"/>
        <property type="gene ID" value="ERS852471_02104"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="244"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="52629" checksum="006DB5A8B8AE1302" modified="2016-09-07" version="1">MRGKLIIHYSVYIILACVFIAFVNITFMGINIYKKGGLYNYHPEEMISAFKDYIVYSEDGNIEVSNDGINKLIEENSGIQILDKNNREVFSYNKPEIAHSNYSNVQLLETYNNEDVTLFLDEKELEGEIYTYLLFLDPSRVKRITYSYDVKLVDEAHMFPILILLNVFLILGISFLYTLRITKPINRIVNKISKLSKGGYKIDTPQKGIYYDVEKCLSQLAGILTFNEKEREKLDEMREEWISNISHDIKTPLTSIIGNAEIMADTEYEIDDRIREKCCTTIINKSQYIKTLIEDLNLSTRLKNNTIVLNKSKINIVSLVRHVLIDIINDEKYNDSNIGFNYSDEEIMLELDEGLIKRVFINLITNAFIHNSNDVKVKIDIQKLDSGNVYISIEDNGKGVSEDELNNIFKRYYRGTNTSKKIEGSGLGMAIAHDIIKAHGAEIKAIGKLGDGLKIEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFV3</accession>
    <name>A0A174HFV3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266383.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71785">
        <property type="protein sequence ID" value="CUO71785"/>
        <property type="gene ID" value="ERS852471_02117"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="30878" checksum="9F03280657DD8AFE" modified="2016-09-07" version="1">MNFNIVTDSTSDITQVDAREKNIQVVPLRILFEDGEYHDGINISTEEFYNKLESAKVLPQTSQPSPEDFFKIFEKAKNNDEAVLVITLSSSLSGTYQSATIAKNICEYEKIYIVDSQTVTLGLKVLVDYAISLRNDGKSIEETFEILEREKQNIRIFAAVDTLEYLKKGGRLSSAAALAGTLLNLKPIVKVQDGAVSMAAKARGTNNSYSKIKALIEEAGGIDETRPYTLGYTGSSSNLNQFATFIDKTYNLKNCPISAIGSTVGVHAGPGACGIAFFIKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIA6</accession>
    <name>A0A174HIA6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmuC_6</name>
        <name evidence="11" type="ORF">ERS852471_02144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266435.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72908">
        <property type="protein sequence ID" value="CUO72908"/>
        <property type="gene ID" value="ERS852471_02144"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="6"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO72908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="432" mass="46467" checksum="116C4727293FA482" modified="2016-09-07" version="1">MNGSKIQEKVMPIVNKISNNRYLKATSDGVAGALPVIIVGAIFTLLANFPFEPYQNFLANTGLNTLFNLPITFTTNLLSLYAVFFIGYKMSESFDCSGPIAGMISLLCFFIVTPLANVDGTSFISFEWLGATGFFVAILVGLLVGRIYALIVNKNIVIKMPAGVPPTISQSFTGLIPAFIITPIFLVVAAIFTNTSFGSIHSLVYQFVQTPLQGLGGSFGALLIVILVSHFLWLFGIHGTMVVFSIMMPIWTGLDMANLTAYNAGEPLPNIVGSAFLMTYVLIGGSGATMGMNIYMSFRAKSKRYKTLGALALPGSICGINEPLIFGAPCIMNPKLAIPFILSPIACATIAYMLTVTGIVPKLACIGLPLGTPLVVGGFLQGSWMIAALQVLLIVISFLIYLPFIKSLDKEAYAMEQQEDEDDVDFSDVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJA5</accession>
    <name>A0A174HJA5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoesterase</fullName>
            <ecNumber evidence="4">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO74983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266520.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74983">
        <property type="protein sequence ID" value="CUO74983"/>
        <property type="gene ID" value="ERS852471_02202"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO74983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="161" mass="17937" checksum="4CF280504DB59813" modified="2016-09-07" version="1">MLIAVISDSHNNDRAINEVKNYIKNADVLLFLGDGESDIAKITEGFKGEVYSVSGNCDFLGKSPNERIIELDGIKIFMCHGHAYNVKFGYDNIYYRGLSLGVDIVLFGHSHIPIVEKHNDICLMNPGSISHGACMAKRSLGYIEIKEGKIAQIYTKEIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKS1</accession>
    <name>A0A174HKS1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulose-binding family II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266553.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75533">
        <property type="protein sequence ID" value="CUO75533"/>
        <property type="gene ID" value="ERS852471_02220"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415600at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="391"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO75533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="486" mass="54391" checksum="4CD085CE713C5F83" modified="2016-09-07" version="1">MKKKNGFTLIELMVTLSITVLVTTMVGSVFIQGYKILNRTDNKSAIQDEVRNAIMKIEGEALTASKIKIRTTDAINSYNSKSAKELLYLDKVDEKIVYIEVVEDSANNTNKFVEVKLNNDNTFKEEKILINTIQGNVASNFALNSNIEDKVVNINFNNVIKGNQSSGENYIVTLNLNVASDIKIEFGDESSEVTPEIPEGGKEDSEEEKDLLDKLGEHYLTISGEMEFQSNSTHVEVKGNGTLGYGSTSGNKEHFKVGAEKIFQNGIDKLGLDNLNKEELIITESWNIKNHKTYQGYNGFKIIFVNGDIHIGEKNNDNILLNNTIIIATGNVEFEKNDINLRMEDSLIYANSIKFHNKSEVIFTNTLTSQEILNRTKDKLQEMINYYSQPLSVDFSITHSWDNGAKYKILITNNTDKDISSWQIEFDVEKEIIECWAGIVEKVADGRYKIKNQHWNGAIAKGGGIEITGSCAGGVDKIENVKTTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQR0</accession>
    <name>A0A174HQR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266545.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75410">
        <property type="protein sequence ID" value="CUO75410"/>
        <property type="gene ID" value="ERS852471_02215"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2042843at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046208">
        <property type="entry name" value="DUF6241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19754">
        <property type="entry name" value="DUF6241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="219" mass="24415" checksum="BFC2DA8C41BE64EA" modified="2016-09-07" version="1">MDKDNKVIDGNDNDVVDSVEEISQKSISDAQNVNSSEDWKVVQKSEHKGSNVLKAIGIAIAIVVILGGMAWSGMKFYDLSQAPTYNKPEGEPNQVVGNNKEDSEEEPSQDENHTITVDEQRMIEINEYVHHMANTIILAIDGKINGTKKITMETIDEALSMVEEVDWYLYKEISKWKEGDFSNGVEVHNYVWKNLDGEIGKASKLDEAAIEAVKTNLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HV30</accession>
    <name>A0A174HV30_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2508)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266695.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78753">
        <property type="protein sequence ID" value="CUO78753"/>
        <property type="gene ID" value="ERS852471_02297"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2080927at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019644">
        <property type="entry name" value="DUF2508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10704">
        <property type="entry name" value="DUF2508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="82" mass="9732" checksum="2D578A18974B3F0C" modified="2016-09-07" version="1">MIKKNILDFLLIKYEKEERISQQILTELRETINEMEAAESLFNNTNDPRLIEAAIYKETAAKKRFDYLFSIAKEEYGEIIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZD0</accession>
    <name>A0A174HZD0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266759.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80264">
        <property type="protein sequence ID" value="CUO80264"/>
        <property type="gene ID" value="ERS852471_02345"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1406844at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO80264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="23440" checksum="D0518B07CC089C45" modified="2016-09-07" version="1">MLVKIIDQTLEDYEKEFKVRRMNYDQVVVNYPNSKGIKVFDNNEIEFITESEVDEFLIKYNDFLKIKLNRGISVALYKALLEIIESQLNIEFKNLNLLRDKHNVNKRGVWEKEIIAVINNSIPVKILAVGQNFKKIGFNITLDEINKDEFFEMCLFEIEKIRNEIKLKEDSLSRYGMAIENLKKVEKNKSAEKPVKMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I204</accession>
    <name>A0A174I204_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic-di-AMP phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-&gt;5')-adenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="ChEBI" id="CHEBI:138171"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GdpP/PdeA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266773.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80481">
        <property type="protein sequence ID" value="CUO80481"/>
        <property type="gene ID" value="ERS852471_02352"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128306at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106409">
        <property type="term" value="F:cyclic-di-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014528">
        <property type="entry name" value="GdpP/PdeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026583">
        <property type="entry name" value="YybT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="174"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR026583-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="646" mass="72796" checksum="43A7262E3C911D62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IEU4</accession>
    <name>A0A174IEU4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266894.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83575">
        <property type="protein sequence ID" value="CUO83575"/>
        <property type="gene ID" value="ERS852471_02418"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="14"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="32260" checksum="727D68F3BD5C178D" modified="2016-09-07" version="1">MRKTRFLYQHGKSKALTISYDDGVQFDEKLVEILNRYKLKATFNVNSGIKPGTTWINKGIDVTRINLVENKDLYKEHEIAIHTLTHPHLEKLNENEILKEVLEDKINLERIYGGVIRGMSYPFGTYNSKVKDIIRTCGVDYSRTVVENEDFTLPNDFLEWHSTCRHANPRLMEITKRFLEKEDGELDLFYIWGHSYEFEVDNNWELIEEFAEKVSNKEDIWYATNIEVYDYITAVRSLKFSGNKSRVYNPSALDVWISVDGKTVKIDSRETIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ILB0</accession>
    <name>A0A174ILB0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbiO</name>
        <name evidence="8" type="ORF">ERS852471_02524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell membrane</location>
            <topology evidence="2 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267069.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88172">
        <property type="protein sequence ID" value="CUO88172"/>
        <property type="gene ID" value="ERS852471_02524"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030946">
        <property type="entry name" value="EcfA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04521">
        <property type="entry name" value="ECF_ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO88172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="33051" checksum="0E16ABB39AE0BFDC" modified="2016-09-07" version="1">MSIKIENLTHIYMPKTPFEKKALDDVNLYIEDGEFIALIGHTGSGKSTLIQHLNGLLEPSSGKIIIDDIDITEKGVKLSDIRKKVGLVFQYPEYQLFEETIEKDIAFGPTNLGLEQDEILIRVKRAMEMVGLDYEKYKDVSPFELSGGQKRRVAIAGVIAMEPKVLILDEPTAGLDPKGREDILSQIKKLHEEYKMTIILVSHSMEDVGKLAKRIIVMNHGKVALQGEPKDVFKEIDTLEEIGLGAPQVTYLMRELRRRGFNVSDEIFTVEQCKKELLRVLLNDKKINMGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ITA9</accession>
    <name>A0A174ITA9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YdjC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267162.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90662">
        <property type="protein sequence ID" value="CUO90662"/>
        <property type="gene ID" value="ERS852471_02574"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1204930at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10803">
        <property type="entry name" value="YdjC_EF3048_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022948">
        <property type="entry name" value="COD_ChbG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO90662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="28254" checksum="084BECDA3FA7AD34" modified="2016-09-07" version="1">MAKIIVNADDFGYSEGVNHGIISAHKNGIVTSCTVMANMPGFEHGMELIKENPTLKCGVHMTLTCYKPLLKDHKTIVDQNGDFIRKPSEEVIKNIDLEEVYREFKAQIERVRERVEITHLDSHHHVHGREFLRPVIERLANEYKLPIRKSVDMMPIEGIDYAQCLGTFYMDNAKEEYFEEHLEDLRGSEVVDLMCHPAFVDAFLLGSSSYNVQRAKEHKVLTSEKVKKFLDDNGFELVNYSYFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IXQ3</accession>
    <name>A0A174IXQ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267227.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92193">
        <property type="protein sequence ID" value="CUO92193"/>
        <property type="gene ID" value="ERS852471_02614"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444212at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009976">
        <property type="term" value="F:tocopherol cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025893">
        <property type="entry name" value="Tocopherol_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309">
        <property type="entry name" value="PTHR35309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14249">
        <property type="entry name" value="Tocopherol_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO92193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="317" mass="36362" checksum="68D033D6A9807354" modified="2016-09-07" version="1">MSIIRNPNLYHGKNKKDNFFEGWYYKLVTKDRKYTLAIIPGISLSSDSHSFIQVLRGEDVLYDYFRFYKNDFFSSNSYLKINISNNSFSLDGIFLDLYNSKLKIKGSLLFSNLVKWSDSIINPGSMGFYNYLKFMECYSQVCALDGDIKGTLSINDNIIDFNDGKVYIEKNWGRSFPVEWLWIQSNTFKDSRATITCSLGEIPFPLKNFRGFLIGVTVDNMFFPFTTMNRSKLDLKVENNDILLTVIHKNLRLSLKTITDTNSFILCYGPKNGQMVPFVKETLTAKVQMELVDTKNNTLIYSGEGSNTGIEFGGNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J918</accession>
    <name>A0A174J918_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine synthase MetH</fullName>
            <ecNumber evidence="6">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metH2</name>
        <name evidence="6" type="ORF">ERS852471_02679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267347.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95141">
        <property type="protein sequence ID" value="CUO95141"/>
        <property type="gene ID" value="ERS852471_02679"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149455at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="287" mass="32085" checksum="3955347945A89E75" modified="2016-09-07" version="1">MNFKEIKNKGILLFDGAMGTMIKRYGLNINNNPEIYNFTEEDTIKKIHKEYIKAGSNVITTNTFGANDIRLKNSKYSIEEIIRKGIMIAKEVKGDNEDILIAYDMGPTGVGVNATGKLTFDEAYEIFKKQVIIASKGGVDLILIETILSLDECKAAVKAVKDYSNLPVFCTFTLDNDCKLFDGNTIEKAIEDMNKLEVDAVGINCSPGINGIHKIVKKINTLTKKNIIIQPNTRCYMNNLKEFIEISENEFSKEILKCIEEGAKIVGGCCGTTPEYIRRIKEELSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JF65</accession>
    <name>A0A174JF65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_02703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267393.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96527">
        <property type="protein sequence ID" value="CUO96527"/>
        <property type="gene ID" value="ERS852471_02703"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432217at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="182"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO96527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="564" mass="65403" checksum="006AE4B66573084D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JK85</accession>
    <name>A0A174JK85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ppx/GppA phosphatase</fullName>
            <ecNumber evidence="2">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppx</name>
        <name evidence="2" type="ORF">ERS852471_02784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267536.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00142">
        <property type="protein sequence ID" value="CUP00142"/>
        <property type="gene ID" value="ERS852471_02784"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="501" mass="57781" checksum="2BFDC3ED4DEB23ED" modified="2016-09-07" version="1">MVKIGIIHISSSSLRLVLAEIEEIGYFRVVDELKTPMKICYNLNNTCKVCNEKLHYIISTLKTYESLCLASCTSNIIAIATNSFNQICDNEIIVKSLKDNFDLDLRILTPKEEIYYNYLGIVKSLNVENSLVVEITGTSTNLTWVKDGNIEEWSVLPFGNINLTYNYGLNDRILSDSIDECNSFISNHLKDVDWLNNSFESIILIGDVGRNIAKIDKKRRRYPFDNFNNYELLDNEIHELYNMVKSKDLRQRRKIEGLEQDMADTIFTSLAIFHNISDLVSSRYIKISNHSLREGILYEFLDNNYDVIHDILDYSLYGILHSLNCNIDHANQVYKITLDLFNALKPLHHLDDNYLNILKTSSLLHDCGISINYLQHHKHSFYIILNSYINVLNHKELLMSAAIAASHRFNNYQIPVPQFSSIINKLDLKAIYEIGALLKIAEGLDRSLVSSVKDVEVTLNDEEVIILLSSPLNLDVEIHQALRARDFFREVYDRDLIIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPY6</accession>
    <name>A0A174JPY6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ifcA_5</name>
        <name evidence="6" type="ORF">ERS852471_02814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267600.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01854">
        <property type="protein sequence ID" value="CUP01854"/>
        <property type="gene ID" value="ERS852471_02814"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025342" evidence="4">
        <location>
            <begin position="22"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP01854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="560" mass="61420" checksum="8E9E43A87B3A8630" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JSD4</accession>
    <name>A0A174JSD4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP01106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267576.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01106">
        <property type="protein sequence ID" value="CUP01106"/>
        <property type="gene ID" value="ERS852471_02807"/>
    </dbReference>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP01106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="50060" checksum="E4001EC79E6A38E2" modified="2016-09-07" version="1">MDINEKLRILSDAAKYDVSCSSSGSNRNSKKGQLGSVSTSGICHSFTPDGRCISLLKILLTNYCIYDCTYCLNRKSNDIERAAFTVDEIVSLTINFYRRNYIEGLFLSSAIFKNANHTMEMLTNVVDKLRNSYNFRGYIHLKAIPGADESLIKKAGTLVDRMSVNLELPSNDSLKLLAPEKNKESIFTPMKSIKNNIILYNDERKKFKSAPLFVPGGQSTQLIVGATKESDYNILKLSENLYNKFSLKRVYYSAYVPVNTDKNLPSIKNPPTLREHRLYQGDWLLRLYGFKADELLDNKAPNFDINFDPKTNWAINNIHLFPVEINKAPYETLIRIPGIGIRGAKKILSSRRISSLDFEDLKKLGVVLKRAQYFITCKGKYFGSVDIDGDKIKKVLSPKVDLNIIDNNYEQLSFFDNNIALSPSFNKLSLLKDKNSSIIGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JU83</accession>
    <name>A0A174JU83_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267557.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00700">
        <property type="protein sequence ID" value="CUP00700"/>
        <property type="gene ID" value="ERS852471_02797"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077907at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="13586" checksum="3EFCC35337678C47" modified="2016-09-07" version="1">MGILFTVLYFVILLAITFGILFLGRKYVFSKVRINKFIPLGISIALFVLQMFLPKIMQEQNLWLSMILTIVTVTFFLWFLEIQTTGGPKKKEKQIEIRPKAKPNRVKHLKNQKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZE8</accession>
    <name>A0A174JZE8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adeC</name>
        <name evidence="5" type="synonym">ade</name>
        <name evidence="8" type="ORF">ERS852471_02884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267728.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05144">
        <property type="protein sequence ID" value="CUP05144"/>
        <property type="gene ID" value="ERS852471_02884"/>
    </dbReference>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="66"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="417"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="579" mass="63956" checksum="25AE18FDF870507A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K324</accession>
    <name>A0A174K324_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dihydroorotate oxidase B, electron transfer subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrK_3</name>
        <name evidence="7" type="synonym">pyrK</name>
        <name evidence="11" type="ORF">ERS852471_02875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="7 9">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267712.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04836">
        <property type="protein sequence ID" value="CUP04836"/>
        <property type="gene ID" value="ERS852471_02875"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01211">
        <property type="entry name" value="DHODB_Fe_S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023455">
        <property type="entry name" value="Dihydroorotate_DHASE_ETsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="7 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP04836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="27068" checksum="22F04545A8A6C028" modified="2016-09-07" version="1">MKYTKAKILSNTEIVDGIYKMAVEDHNKVNAGQFYMLKHQGATLLPRPISVSEKEEGTVTFLYATVGKGTKEFANLREGETIELTGPLGNGFDIDKKYGNVALVAGGIGIAPMVELAKRLREKNKGMKMDLYAGFRDDIYLTDELCKYINDGYVSTNTGKYGHKGFVTDLLEVDKYDTVLCCGPEVMMKKVVEMCKEKGVQVYVSMEKHMACGVGACLVCTCKTKDGNKRTCKDGPVFDGNYVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KA01</accession>
    <name>A0A174KA01_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative arabinogalactan oligomer transport system permease protein GanP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ganP</name>
        <name evidence="7" type="ORF">ERS852471_02913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP06109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06109">
        <property type="protein sequence ID" value="CUP06109"/>
        <property type="gene ID" value="ERS852471_02913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
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        <location>
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            <end position="427"/>
        </location>
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            <end position="490"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="464"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP06109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="695" mass="79321" checksum="B63C3AF5B7E7988C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KD72</accession>
    <name>A0A174KD72_9CLOT</name>
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        <submittedName>
            <fullName evidence="9">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tetA_2</name>
        <name evidence="9" type="ORF">ERS852471_02987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09963">
        <property type="protein sequence ID" value="CUP09963"/>
        <property type="gene ID" value="ERS852471_02987"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="186"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="8"/>
            <end position="391"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP09963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="43954" checksum="C375C78B214EDCC2" modified="2016-09-07" version="1">MGKLNYKKTFLLGFGFFATSITWSVYNAFMPKLLSNFITSSAIIGFIMTFDNYFALFIQPAVGMYSDGIRTRFGRRMPFLMVGMPLAVLFIFLIPNYKGLATLIAALLLMNLSMSLFRSPVIALMPDITPEDQRSKANSIINFMGGIGSLIAFFIGSILWKLSPKYPFYLAGVLVLLSFVILFTCIKEKRDVINYEQAEKKVNFKEGFKVAFKNPSTKFLLMAICSWFIGYNGIETFFTRYSEMYLGIDVSAAAFSFTFVSLSFLVFAIPAGIIGTKLGKKKTITIGLIGAMAIFCILIFVKNILIIRAFFLALGVFWAMININSYPFVAQMSPLGYLGTFTGMYYLFSSIANIISPPLLGLLFDLIGYNCMFVYGLFFMILAFLFMRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGT5</accession>
    <name>A0A174KGT5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267980.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11132">
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        <property type="gene ID" value="ERS852471_03018"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000095594">
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="155" mass="17549" checksum="E23CFDB0583057FE" modified="2016-09-07" version="1">MFREIRKKSREIFDNDITTILNSAEYGTLATVDEYGMPYATPLNYVYYDNAIYFHSSPYGHKLDNIANNSKVSFCVVTDTCIIPEKFTTKYKSVVAFGTASWVIGTVKEAALIEFIKKYSPEYLEKGKAYVEKAKASTTVIKIEIDYLTGKSSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KK03</accession>
    <name>A0A174KK03_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rsgI</name>
        <name evidence="10" type="ORF">ERS852471_03019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267982.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11161">
        <property type="protein sequence ID" value="CUP11161"/>
        <property type="gene ID" value="ERS852471_03019"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1808279at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RSGI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RsgI N-terminal anti-sigma" evidence="9">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="33960" checksum="830E1490830A1EF9" modified="2016-09-07" version="1">MFKGIVMEIKDDYVIVMKEDGTLARIKNKDGLKIGNPIFFFEEDIYVKKEAAKVIPFKKYIVPLGAIAALFIILINPIMNIFTTKMNNVYAVLTFDINPSIEFNLDEKGIIKSVKGINDEAIALGLDKIKGMTFEEGTIALRDLLSQSNYLNNNNAVLVGFSFIGNENIDYEKDIQQVIKNTFKGTDVAFLKGEKSDLEKAQSQGISLGKYEALVKLDEDNFEDAIENLTTQEMLELLRNVDGSIFLDEDQLEELQDELEDRLEDEIENEDEDENEDEDEDDEYDENDDIDDDEKNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQS2</accession>
    <name>A0A174KQS2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate formate-lyase</fullName>
            <ecNumber evidence="5">2.3.1.54</ecNumber>
            <ecNumber evidence="5">4.1.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csdB</name>
        <name evidence="5" type="ORF">ERS852471_03036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.54" evidence="5"/>
    <dbReference type="EC" id="4.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268017.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12228">
        <property type="protein sequence ID" value="CUP12228"/>
        <property type="gene ID" value="ERS852471_03036"/>
    </dbReference>
    <dbReference type="OrthoDB" id="116406at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043722">
        <property type="term" value="F:4-hydroxyphenylacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="12"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="720"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="841" mass="94180" checksum="5058DCA75BA8706C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTN3</accession>
    <name>A0A174KTN3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">polX</name>
        <name evidence="2" type="ORF">ERS852471_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268043.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12855">
        <property type="protein sequence ID" value="CUP12855"/>
        <property type="gene ID" value="ERS852471_03050"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="295" mass="33178" checksum="58C17F01A64A14C0" modified="2016-09-07" version="1">MSYIDLHMHSNYSDDGEFSPQKIAELCLEKGVKYFAIADHNSTKGVAEAKEYCDDKDITIIPAIELDCTIDGVNLHLLGYNVDYKSDDFKRIEENIIAQEQVASKERMRLVRELGINFEDSVIDGLSKNGVVNGEMIAEAAMLFDKNKENKLLNPYYEGGLRSDNPYVNFYWDYCSQGKPAYAEVKFISLQEAIKVVEDNGGIPVLAHPGNNVKENKDLLEKIIKAGVKGLEVYSSYHNEKQTAFYKDFAINNNLIMTCGSDFHGKTKPSISIGGISCEDNEEKIINELSKKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L533</accession>
    <name>A0A174L533_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pbuG_2</name>
        <name evidence="8" type="ORF">ERS852471_03122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268172.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16679">
        <property type="protein sequence ID" value="CUP16679"/>
        <property type="gene ID" value="ERS852471_03122"/>
    </dbReference>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP16679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="433" mass="45873" checksum="5C18262312C30CA4" modified="2016-09-07" version="1">MNFISNYFQFKEKGTNFKTELIGGLTTFLTMAYTLFVIPEVLSNTGMPKEAVFVATALAGAIGTLIMGIYAKFPMALAPGMGLNAFFTFSVCLGMNIPWQTAMAGVLASGIIFIILSITGFRETVIKAIPNNLKYAVSAGIGLFIAFIGFKNAGIVVADPATFVALGNLTEPSVLLAIFGLIVMAVLTVRGNKIAIFIGLVVTVCVGMIFGLVDVPKAIISIPPSIAPTFGVAVKNLGNIFNPQMIMVIFTFLFMDFFDTAGTIVAVGSKIGLIKKDGYVEGGSKALLADSVATCVGAVLGTTNTTSYSESLSGIAVGAKTGFSSVVVGVMFLISLFFSPLLSVITTQVTAPALIIVGSLMFMSVADVEWNKSEIAISSFLTIILMPLTYSIGEGIAFGFLTYVILMLAKKKYKEVHPVMYGLAVLFIIYFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LBV4</accession>
    <name>A0A174LBV4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gmuD_2</name>
        <name evidence="5" type="ORF">ERS852471_03186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268277.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20017">
        <property type="protein sequence ID" value="CUP20017"/>
        <property type="gene ID" value="ERS852471_03186"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP20017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="466" mass="54144" checksum="E767DD0564A8EE4E" modified="2016-09-07" version="1">MKDCRLPKDFFFGAAMSGPQTEGSHNKGGKLPSFWDRYSDLEINKFHNNVGSYVGNDFYNKYEDDIKLLKSLNFNSFRTSIQWSRFLDRDGNINPEGAEFYHRVIDCALENGLDIFINLYHFDMPAYLCDRGGWESRDVIEAYANYARKAFKEFGSKVKHWFTFNEPIVEPMCTFHQALWYPYIRDEKRAMTVQYHITLAHCLAVNEFRLAQKAGELCEGARIGLINCFAPPYTKENPSTEDLEAVRMEDGIHNRWWLDVVSKGELPQDVLDTLEEYGIAPYIRPGDKEIISLGKVDWLGFNYYQPARVQAPAKKFDEEGNPIFSDPYIWPDRKMNVHRGWEIYPKGIYDFGMKIKNECPGLEFFISENGMGVEGEAKYADENGVIQDDYRIEFVKEHLEWVAKAIEDGANCVGYHYWGAIDNWSWMNAFKNRYGFVSVDLMDGYKRKKKKSADWIAKVAETKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHP4</accession>
    <name>A0A174LHP4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268328.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21375">
        <property type="protein sequence ID" value="CUP21375"/>
        <property type="gene ID" value="ERS852471_03211"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="31496" checksum="B1412775DD61C80C" modified="2016-09-07" version="1">MQKIAIITDSGCDLSQETIKENNIHVLPFRIIYSDREFLDKVTISEEKVYEDLANGIIPTTSLPDLQYTENIIEKLKNEGYTHAVVVTVSSNLSGTFNSIQLLCEEHPELTYHFFDTKTLGFPVGAMALEVAKLIKEKASFKEIVDKLPSIKENVSAYVTFNTLEFLKRGGRIGKVAGTVGEILHLKPIISSDDEGQLYPFCKVRGRKKSISKLKEILNSYLNEGKCRVWVLNGAALEEARAFFEEIKNYHNISKISFETIGAAMGVHTGPGAIGLCIKKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJP1</accession>
    <name>A0A174LJP1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
            <ecNumber evidence="11">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgcA_2</name>
        <name evidence="11" type="ORF">ERS852471_03241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EC" id="5.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP22936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268381.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22936">
        <property type="protein sequence ID" value="CUP22936"/>
        <property type="gene ID" value="ERS852471_03241"/>
    </dbReference>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="162"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="267"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="419"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP22936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="53160" checksum="E59A6E21AF527BF9" modified="2016-09-07" version="1">MIKFGTGGFRAIIGDEFTKDNIQQLARAVARMMKDENVEKKTVVIGYDRRFLSKESMIWISEVLAYEGIKVMMINRSMPTPLMMFEVKKQGLDYGMAVTASHNPAIYNGVKLFTKGGKDADEVVTKNVENYIEKLENEPLRWIDYEDAVKSELIVPYNPFNDYIDSILSQIDLDSIKKANLRVVLDPMYGVSQTSLRTILSTARCELDVINERHDTLFGGKLPSPNVDTLRALQQHVLDRHYDIGIATDGDADRLGVIDNNGRFLHPNDILVLLYYYLVKYKGWNGPVVRNIATTHLLDKVAESFGQKCYEVPVGFKHISAKMIESDAIIGGESSGGLTVKGHIQGKDGVYAASLLIEMIAVTGKSLSQIYEDICKEYGELFMTESDYAMTHNRKEELIKQIMIDKKPIEFPYEIEKVSYLDGYKVYFKNGGWVIIRFSGTEPVLRVFCEMDTLEKAQEVSDIVKNTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJW0</accession>
    <name>A0A174LJW0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP22877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268379.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22877">
        <property type="protein sequence ID" value="CUP22877"/>
        <property type="gene ID" value="ERS852471_03239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008027137" evidence="1">
        <location>
            <begin position="30"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP22877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="432" mass="47437" checksum="5C1325B4A662D3E5" modified="2016-09-07" version="1">MKMKKLMSILLAGCMAFSLTACGSKDNSGDTGSTNADASTGNDTTVSADSGELTYWSMWNNTEPQAKVIKEAIDAYTAETGIKVNVEWKGRDLGTVLQSALEAGEKIDFFDWDYQKIALEYADKVLNLEDMAKAVNYDDFAIKALPASVRRWAGSLVTIPYQPYTSGIFYNKAMFEEAGIEKEPQTWAEFLEVCQKLKDLGVAPLAQDDAYVDYAFGYHLARYAGQAEVENIAINGDWAENENVLKAAQDIVDLIEKGYFSEYAPGAYPEGENEVGYEEAAMLVNASWVPAEITNNTGCDLEWGMFNYPSVDGGKDPNTIANVGAQGFAINKNSENAQAAFDLIMKITTGEYDQKMALECGGIPADSRNEEWPEDLVGVRESFLALTETYDWNAGLNANPDVKETIKTNCLQLFEGKLTAQEFVDAMESATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LVD6</accession>
    <name>A0A174LVD6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ebgA</name>
        <name evidence="10" type="ORF">ERS852471_03323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="CYZX01000045">
        <property type="protein sequence ID" value="CUP28194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268507.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28194">
        <property type="protein sequence ID" value="CUP28194"/>
        <property type="gene ID" value="ERS852471_03323"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245411at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="9">
        <location>
            <begin position="735"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP28194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1009" mass="116596" checksum="C948314020D0BB39" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M8U9</accession>
    <name>A0A174M8U9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000057">
        <property type="protein sequence ID" value="CUP30159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP30159">
        <property type="protein sequence ID" value="CUP30159"/>
        <property type="gene ID" value="ERS852471_03341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP30159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="86" mass="9828" checksum="C72F8B6D1F4194D8" modified="2016-09-07" version="1">MLDGLEEQNIRYEVLALELIGELNLAKVPFNLAVELDQDNVELKSSDFKGLVNFKVTISNKKIAKEFGLDVGRYIKKIPLKGDWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDZ2</accession>
    <name>A0A173XDZ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN48865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262668.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48865">
        <property type="protein sequence ID" value="CUN48865"/>
        <property type="gene ID" value="ERS852471_00002"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="58"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN48865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="406" mass="44419" checksum="DDB1863BEC4F7E78" modified="2016-09-07" version="1">MSREYIIKAKKIVTVGKDKTIINGAMVIKEDKIIDIGKEKVIISKYKDLDIEDLGNLVITPSLIDCHTHLLEYAPSTVYPVTSETYNIAQKALVLKALMAGVTTFGEQICGSPMTLLSVEDFKKLAKDLPVNIIFSCNSITIGFEELVNFTAVTGNNSVDKDKLIEDKIINSLIEKSDYPGENIFINATPANLTEDIVPRAGEVIYTQEELENIVQVFHSKGKRIGCHVAGKDAIEMAIKANFDVIHHGHGITDDEINEVSKNKISIVATPLGGTHLKPNSPEDILKLIQNNILVAIATDAYLPPYEGVSWLNFNDKEAKGSPELMIISKPVIDKLIGSGYDENEALSLITLNAAKVLGIEEKIGSLEIGKDADFIVSSGIPVVEFSDASNIKRVYLKGKCLINRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJW2</accession>
    <name>A0A173XJW2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmF</name>
        <name evidence="6" type="ORF">ERS852470_01435</name>
        <name evidence="5" type="ORF">ERS852471_00332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834855</strain>
            <strain evidence="5 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZV01000013">
        <property type="protein sequence ID" value="CUO09872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005213472.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="84024.ERS852471_00332"/>
    <dbReference type="EnsemblBacteria" id="CUN68258">
        <property type="protein sequence ID" value="CUN68258"/>
        <property type="gene ID" value="ERS852471_00332"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09872">
        <property type="protein sequence ID" value="CUO09872"/>
        <property type="gene ID" value="ERS852470_01435"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000095558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN68258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO09872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="61" mass="6974" checksum="66DCEC3326B7DD61" modified="2016-09-07" version="1">MGNPARKTYRAKRDSRRAQTFKLSLPGIVECPQCHEMKMAHRVCKNCGFYKGKEVVASTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XUS6</accession>
    <name>A0A173XUS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrrB_1</name>
        <name evidence="2" type="ORF">ERS852471_00129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262885.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55464">
        <property type="protein sequence ID" value="CUN55464"/>
        <property type="gene ID" value="ERS852471_00129"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN55464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="30359" checksum="D3F1D9E393340AB5" modified="2016-09-07" version="1">MELNMDFLREYENLMNEDVEKALEFCINTLEESNNPEIYIYIGECYMALNLFEEAIEAIDKGLKEGSVNINFAKSLKGESLFYLEKYEESKEIFLELLKERPNSFFSIAYLTDIDIKLGNYKEGVERAEEALKKNKLDSKDSAYIEVNIGWIKLKYLNKEDEALNHFNHALDLDNNLGNAYIGFAEYYLRKEEYFKAIDNFEKAIDLGENTLDVYFGMGLAYKGLGQLEDALEYFKVVYNADESYEEAKKEIELIESVQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZB3</accession>
    <name>A0A173XZB3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rbfA</name>
        <name evidence="2" type="ORF">ERS852471_00159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262938.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56999">
        <property type="protein sequence ID" value="CUN56999"/>
        <property type="gene ID" value="ERS852471_00159"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="13537" checksum="6F8A30173DD34FDF" modified="2016-09-07" version="1">MANYRGGRINEEVKREISNIIRNEIKDPRLTAMVSVTDVKVTKDLRYAKVYVSIFGKDEEEKNNTFLALKNASGYIRREIGQRINLRYNPQILFELDDSINYGMHIEELIAKVKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZI8</accession>
    <name>A0A173XZI8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxK</name>
        <name evidence="3" type="ORF">ERS852471_00153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56710">
        <property type="protein sequence ID" value="CUN56710"/>
        <property type="gene ID" value="ERS852471_00153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN56710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="31200" checksum="D720ACA055EF92A2" modified="2016-09-07" version="1">MSKVVKKVATVQDIAGIGRCSLTAAIPILSVLGVQPCPLPTAILSCQTEYPNFHFYDFTNEMRDYIDSWTSMNLSFDGIYSGFLGSEDQINIVIELIERYREALIVVDPVMGDNGEKYKTYTIEMCNKVKDLVKHANIVTPNLTECCILTDRKYEDVVDVINEETLFEIAREISELGPEKVVITGVIKDDEVITFAYDKERDESFSFSNPYNNKSYSGTGDIFASIICGMLVRGFDFKIAVNKACDFIKNAVYMTSLENADERNGIFFEPLLKDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YD82</accession>
    <name>A0A173YD82_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">luxQ_1</name>
        <name evidence="9" type="ORF">ERS852471_00229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263068.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60718">
        <property type="protein sequence ID" value="CUN60718"/>
        <property type="gene ID" value="ERS852471_00229"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="404"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="543"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN60718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="795" mass="91595" checksum="2FD36AA3895ECE80" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKA0</accession>
    <name>A0A173YKA0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mnmA_1</name>
        <name evidence="7" type="synonym">mnmA</name>
        <name evidence="9" type="ORF">ERS852471_00265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263157.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64581">
        <property type="protein sequence ID" value="CUN64581"/>
        <property type="gene ID" value="ERS852471_00265"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="305"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="358" mass="40161" checksum="2850268608A7A403" modified="2016-09-07" version="1">MKKKVVIGMSGGVDSSVAAYLLKEQGYDVIGVTMQIWQEDNEYTEREGGCCSLSAVDDARRVADKIGIPFYVMNFRDSFKEKVIDYFVQEYIDGKTPNPCIACNKYLKFDELLRKAKGIGADYVATGHYAKIEEKDGRYLLIRSDDDRKDQTYALYNFTQDQLAHTLMPCGEYTKDRIREIAKEIGLAVHNKKDSEEICFIPDNNHGRYISEARPLEVVPGNFVDKNGNILGKHKGIVYYTIGQRKGLGIALGRPVFVTDINPQTNEVVLGPEIDIFKTDLVAKDVNFIPFDKLEGELTVEAKVRYSGRPAEAVISQLEGNRVKVSFKDKQRAITKGQSVVFYQGNIVVGGGIIEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YL61</accession>
    <name>A0A173YL61_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263141.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64087">
        <property type="protein sequence ID" value="CUN64087"/>
        <property type="gene ID" value="ERS852471_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="109" mass="12489" checksum="3D02F8A4036A258C" modified="2016-09-07" version="1">MFNMAIIVIGIIEFCIGVTISVFSKSKKINGFIKFLYDFEDEEGKIQSILNKWIGENYGIVGSMYVFLASIAIAFNVDWFMLILEISIVEFLSYKRINKGIKDIIKDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSQ6</accession>
    <name>A0A173YSQ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">engA</name>
        <name evidence="7" type="synonym">der</name>
        <name evidence="11" type="ORF">ERS852471_00298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263217.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66276">
        <property type="protein sequence ID" value="CUN66276"/>
        <property type="gene ID" value="ERS852471_00298"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="177"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN66276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="438" mass="49112" checksum="BEABB8EB45A29684" modified="2016-09-07" version="1">MGKPIVAIVGRPNVGKSTLFNKLAGKRISIVQDTPGVTRDRVYAEAEWLNHVFTMIDTGGIEPENQDIIVKQMRRQANIAIETADVIMFVVDGKEGLTAADNEVATMLRKSKKPVVLVVNKIDNLKDEENAWEFYNLGIGDPVAISAGQGKGLGDMLDMVVSHFDSIGEADEEEEDIKIAMIGKPNVGKSSLINRLLGEDRLIVSEIAGTTRDAIDSKIETDFGKFTLIDTAGLRRKSKVKEEIERYSVIRTLTAIERADVCILMIDATEGVTDQDEKIIGFAHELNKAIMVVVNKWDLIEKDGKTMDVYKKDLQSNLKFISYAKYLFISALTGQRAHKVLEVAKECYDNYSKRVGTGVLNDVISKAILMKEPPVVALKRLKIYYATQVATKPPKFVFFVNDTNARHFSYERYLENQLRDSFDFSGTGIQIEYRERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWZ8</accession>
    <name>A0A173YWZ8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">prkC_2</name>
        <name evidence="11" type="ORF">ERS852471_00316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263251.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67288">
        <property type="protein sequence ID" value="CUN67288"/>
        <property type="gene ID" value="ERS852471_00316"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="373"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="440"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="507"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN67288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="674" mass="74853" checksum="407B0ECB65F27D41" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8S0</accession>
    <name>A0A173Z8S0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chlorohydrolase/aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssnA</name>
        <name evidence="3" type="ORF">ERS852471_00406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263409.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72297">
        <property type="protein sequence ID" value="CUN72297"/>
        <property type="gene ID" value="ERS852471_00406"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017700">
        <property type="entry name" value="Aminohydrolase_SsnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03314">
        <property type="entry name" value="Se_ssnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="56"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN72297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="49376" checksum="38AF1CBF99DBC404" modified="2016-09-07" version="1">MILVCNGRVITHDENNPFIENGAVLIDGNIIKEIGTTKELRVKYGQAEVIDVSGKVIMPGLINTHHHIYSAFARGLNLNNPPAKSFTDILKNVWWKIDKKLTEEDNKYSAYTTLIECIKDGVTTVFDHHASPMSVEGSLFTLAKAAEDLGVRGSFCYEVSDRDGKDILEAGIKENIDFIKYANSRTDDMVKGMFGMHASFTLSHESLLKCVDAMEGLDVGYHVHVAEGIEDVYDSLNRSGKRVVERLNDYGILGEKTLAVHCIHVNDREMDILKETNTTVINNPESNMGNAVGCAPVIRFFEKGLTVGLGTDGYTSDIFESIKVENIIHKANLCNPNIGFMETGTMAFKNNSKIASKYFKNEVGILKEGAYADLIVVDYNPLTVMNENNLFGHIFFGMTGRSVDTTIINGKVVMKDRKILTVDEEEILTKSREVSAKLWDRLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAL4</accession>
    <name>A0A173ZAL4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arcC</name>
        <name evidence="7" type="ORF">ERS852471_00404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:10152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; carbamoyl phosphate degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263405.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72218">
        <property type="protein sequence ID" value="CUN72218"/>
        <property type="gene ID" value="ERS852471_00404"/>
    </dbReference>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00996">
        <property type="reaction ID" value="UER00366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035975">
        <property type="term" value="P:carbamoyl phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN72218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="33238" checksum="ADB66F411E1BFC9C" modified="2016-09-07" version="1">MSKVVIALGGNALGNNLEEQMVAVRSTAKAIIDLIEDGNEVIVSHGNGPQVGMINLAMTELGKNYPKYSLCPMSVCVAMSQGYIGYDLQNALREELLERGINKSVSTIITQVEVDKNDAAFTNPTKPIGGFMTKEEADLMVQKGENVIEDAGRGYRRVVASPKPKSIVEIETIKTLADAGHVVVACGGGGIPVIKKDGKLKGVDAVIDKDFASCELAKELDADCLIILTAVEKAAINYGKENQKWLDDVKVEEMKMYVEEGQFAPGSMKPKVEAAIEFAESKEGRYALITLLERAKDGIAGKTGTRISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBT2</accession>
    <name>A0A173ZBT2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rnfB</name>
        <name evidence="9" type="ORF">ERS852471_00425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263439.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73130">
        <property type="protein sequence ID" value="CUN73130"/>
        <property type="gene ID" value="ERS852471_00425"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00463">
        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="8">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN73130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="27435" checksum="D0F11E35766D33D5" modified="2016-09-07" version="1">MLEAYLVPIAIFIVLGLIAGLLLSIASKKLAVEVDERVGKVRECLPGANCGACGYAGCDEYAVALIEKNEKITLCKPGGAAATAQIGEILGTEAEVGEREVAFVKCNGVPSATNAKYEYKGTQTCAANNLLFSGKGSCAFGCLGFGDCTVSCEFDAIHIVDGVAKVDPEKCTACGACIKTCPKAIIALRPISKEVKVLCNNKDKGGITRKACTNGCIGCMKCQKTCEFGAITVTNNVASIDHSKCTNCKACVEVCPVKCIHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBY4</accession>
    <name>A0A173ZBY4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-associated metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263441.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73180">
        <property type="protein sequence ID" value="CUN73180"/>
        <property type="gene ID" value="ERS852471_00426"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667936at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="184" mass="21059" checksum="9124ED8C2D95514B" modified="2016-09-07" version="1">MKGKEHMIVGTTATATMGIGFLLTNTISSVIYLVPLILGGFIGSYMPDIDSHNSKARQFFNKFIVILIIALVIGYMLGMALSIDNIISFLNKHWDEYFPYILFFALVILGKLSPHRMFTHKWFGTILFCFSVYLIGNIYLTLGFSMGYILHIVCDRFSPKGKKLKFFEFKLPCRNTKNKITICW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHF9</accession>
    <name>A0A173ZHF9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolS_1</name>
        <name evidence="2" type="ORF">ERS852471_00462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263507.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75099">
        <property type="protein sequence ID" value="CUN75099"/>
        <property type="gene ID" value="ERS852471_00462"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="329" mass="37586" checksum="696F9EB645276A9A" modified="2016-09-07" version="1">MEYIKLGNSDLNVSRICLGCMGFGDSNKGIHSWTLDEEKSTEIIKKALDEGINFFDTAIAYQNSTSEKYLGRALKKLAKREDVVIATKFLPRTQKEIDSNVTVKEHINNMLNQSLSNLETDYIDLYICHMWDYTAPIEETMEALNEQIEQGKIRYIGISNCFAWQLEKANSIADRNGWSKFISIQNHYNLLFREEEREMVPCCKDGNIAMTPYSPLASGRLVRDWSETTKRLEEDSFAKSKYDLTANEDRIIVERVAEIAEKRGMTRIQVALGWLLSKTSAPVVGATKISHIEDAVKAIPIRLTEEEIEYLEEPYIPHKLVGVMAQNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZUF7</accession>
    <name>A0A173ZUF7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">galK</name>
        <name evidence="15" type="ORF">ERS852471_00496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79230">
        <property type="protein sequence ID" value="CUN79230"/>
        <property type="gene ID" value="ERS852471_00496"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="288"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN79230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="390" mass="43903" checksum="BCB0F6AAD88B9D17" modified="2016-09-07" version="1">MNKNEMMDLFREEYGNSNQEIYTFLSPGRVNLIGEHIDYNGGFVFPAALTVGIYGALTLREDNIIRMRSKNVEGEVVINLDKELVYDRQDDWGNYPKGVIKELKDRGHKVKGMDILFYSNLPDGAGLSSSAALEVLMAYIILYLENPEKCEEIDRVEVSRLCQKVENQFIGVNCGIMDQFAVCLGKKDNAILLDCNSLYYEYAPLKLGNYSLVIMNTNKRRELADSKYNERRGECEKALEIINSNKEEKVANLCSATVEDINSFIKDDVVKRRAIHVVTENERVKKSMEALKAGDIKGFGELMTQSHISLENDYEVTGLHLDTLVHEALKIEGCIGARMTGAGFGGCAIALVDEAKVDEFKEKVTENYEKVTGIRPLFYTSKLGEGTHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9Z9</accession>
    <name>A0A174A9Z9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263735.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85472">
        <property type="protein sequence ID" value="CUN85472"/>
        <property type="gene ID" value="ERS852471_00579"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930683at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017519" evidence="1">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN85472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="177" mass="19759" checksum="0548B331764F93F2" modified="2016-09-07" version="1">MKKILISTIFVLILTFIITSYTSAENVKNNIELEKAIISNVKVTTEGNRYMTFYEDINGGTNNEVLVYIWGPDFSNSCGDTLLVFTEENGNYSFISKTTSVNMPIIISNSKTNGFNDIIVYVTGGGVKNGFYTALKNQEGRYPLNPSVQPKVDLDKIHVKRLINVNINQSTGEELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ABK0</accession>
    <name>A0A174ABK0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_1</name>
        <name evidence="6" type="ORF">ERS852471_00581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263739.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85573">
        <property type="protein sequence ID" value="CUN85573"/>
        <property type="gene ID" value="ERS852471_00581"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="50302" checksum="B731ADF7029F08E7" modified="2016-09-07" version="1">MQHNQTEELGTCSVGKLLFKLAVPAIAAQIINLLYNLVDRMYIGHIANVGKLALTGVGVCLPLIMIISAFAALVSMGGAPRASIFLGKGEKDTAEKTLGNSFTLLVIISITLTIIFLFFAEDLLLLFGASENTITYATSYMRIYSLGTIFVQLTLGLNAFISAQGFAKTSMLTVLIGAITNIILDPIFIFGFNMGVAGAALATIISQSLSMIWILFFLTGKKTTLKIRKKHLRLSKEIILPSIALGLAPFIMQATESLIAVCFNSSLLKYGGDIAVGAMTILTSVMQFSMLPLTGLTQGGQPIISYNFGAKNADRVKKAFKLLLISCLTYSTVLWASAMIFPQAFILIFNNDPELVDFASRALRIYMAVSCIFGIQIACQQTFIALGNAKASLFLALLRKIILLIPLIYIMPMFMEDKTTAVFTAEPVADILAVTTTAILFIIQFKKAMKEISTPLDDKNSINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AF85</accession>
    <name>A0A174AF85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263755.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86340">
        <property type="protein sequence ID" value="CUN86340"/>
        <property type="gene ID" value="ERS852471_00589"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="189" mass="22303" checksum="B18E02FEB2CB4BE5" modified="2016-09-07" version="1">MRSILIIVDTDDRDKELRDEIVKKIDNHVEGKVEKYFLYLDDMNLNPCVGCFNCWVKTPGKCIINDDNELKNRLFIECDYIVLVSRILYGMYSPSFKVILDRMIPNISPFFQLANGEMHHKKRYKKDFKMFVIGYSTKLYTGEASTFKELFNRNMINFHCKENEFLILEDSNNIQNKITTRLDNLCGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFJ9</accession>
    <name>A0A174AFJ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263753.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86285">
        <property type="protein sequence ID" value="CUN86285"/>
        <property type="gene ID" value="ERS852471_00588"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1358314at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="219" mass="24787" checksum="E718916779BA686A" modified="2016-09-07" version="1">MNIVLINGSPKGEKSCSKYLLEVVKSYFDKENNVYEISIADKRIKDVDKFHVLTNCDNIVIAFPLYVDCLPSTVIKFLEGFEKYTKENNIKCDSRIYGIVNCGFYEGKQNRQALKILRNFTNHIEKLRYGGGIGIGTGPFIGNSSSIPWQAKIKSSIKEVLDKLIDVINSGESMGKDLYAEANMNKVLYMQAGNFGWISSGFKNKVYITSFNKKPYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGU3</accession>
    <name>A0A174AGU3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hsdR_1</name>
        <name evidence="15" type="ORF">ERS852471_00595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263767.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86706">
        <property type="protein sequence ID" value="CUN86706"/>
        <property type="gene ID" value="ERS852471_00595"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="15" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="357"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="599"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN86706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1113" mass="129324" checksum="3E341050041A314E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AUQ2</accession>
    <name>A0A174AUQ2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydroxylamine reductase</fullName>
            <ecNumber evidence="7">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hybrid-cluster protein</fullName>
            <shortName evidence="7">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hcp_1</name>
        <name evidence="7" type="synonym">hcp</name>
        <name evidence="8" type="ORF">ERS852471_00662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="7">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263884.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91216">
        <property type="protein sequence ID" value="CUN91216"/>
        <property type="gene ID" value="ERS852471_00662"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337713at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="7">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN91216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="573" mass="63185" checksum="3654F7B40524E25A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZZ9</accession>
    <name>A0A174AZZ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263948.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94034">
        <property type="protein sequence ID" value="CUN94034"/>
        <property type="gene ID" value="ERS852471_00684"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1705690at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="39307" checksum="9749A12DF33E8816" modified="2016-09-07" version="1">MKEDRKYYESKDDNSDYINFEFTLVPYEEEYRQGPPFFPMPNIPFFPGNTPPPPGSPVNSGGPQGGPPNYIPSKNDKGVQKLSGSGDKKGEKDGLSTKAVSPGSISFCLYKFTYIWETNGRSYWCYLLNVDSRSVSGFRWLGRSWVYFGVDLRRIDSFICYRAEENYNYETSDLTRGSEVEYEATKQEFSLSDVREIYSKTLAYIDIPETKDDYLVETIGVVEGNSVQSKIPCKKTRVTSYRIVLEVSYPSDFDESIKESINNIVDECSEAAVDTLNMMREKDKYLNPLELFNTALKAIPTALKAFSAKFSVCIKKIPGYSEISKYIKYTIRREKNSDRWRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5S4</accession>
    <name>A0A174B5S4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system lactose/cellobiose-specific transporter subunit IIB</fullName>
            <ecNumber evidence="5">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">chbB_1</name>
        <name evidence="5" type="ORF">ERS852471_00707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263987.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95549">
        <property type="protein sequence ID" value="CUN95549"/>
        <property type="gene ID" value="ERS852471_00707"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846001at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN95549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="102" mass="11511" checksum="2E3B08BA52E35362" modified="2016-09-07" version="1">MKKILLVCEAGMSTSILLSKMREYVKVKKVDIDIKALPITECEEVINDVDIVLLSPQVRFQMPQVNALVNGRVPVKVIDVILYGMMNEKAILDQVLNLLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BEZ4</accession>
    <name>A0A174BEZ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AlgI-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">argI</name>
        <name evidence="11" type="ORF">ERS852471_00780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264117.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99572">
        <property type="protein sequence ID" value="CUN99572"/>
        <property type="gene ID" value="ERS852471_00780"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN99572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="458" mass="53345" checksum="FA4DC0FF65A0D499" modified="2016-09-07" version="1">MVFSSILFIFRFLPLALGIYYLTPKKYKNFILIILSLIFYSWGEAKYFVIMISSIIVDYFVSRGIEKYREKKSIKIGLLCISICFNLGMLFFFKYFNFFIDNINSILGLTLNHVKITLPLGISFYTFQTMSYTIDVFRGKVSAEKNIISFGAFVCLFPQLIAGPIVKYTDINKELKERKMNANQIEDGIELFILGLGRKVLIANNIGMLWTEVEGLGFSNISSILAWLGVIAFAFQIYFDFSGYSLMAIGLGKMLGFNFPQNFNNPYISRSITEFWRRWHITLGSWFREYVYIPLGGNRVNKGRLVFNLFIVWFLTGFWHGASYNFIMWGIYFFILIGIEKLGLLKFLENHKIFSHIYSIFFILIGWALFAVTDLSQLKILFERLFNMNGGIDWIYYIRNYGVTLIVATLFSTPIIEITYRRVVKSKLINTLILMGIFIISIAYLVDATYNPFLYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIT2</accession>
    <name>A0A174BIT2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264115.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99516">
        <property type="protein sequence ID" value="CUN99516"/>
        <property type="gene ID" value="ERS852471_00779"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1988689at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025648">
        <property type="entry name" value="DUF4358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14270">
        <property type="entry name" value="DUF4358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018469" evidence="1">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="161" mass="17132" checksum="6E0520A5D4F76E78" modified="2016-09-07" version="1">MKKILVSLLVAAMVGATLTGCGSKAEGNGTQVEQGSSVSAADIVEQLKEYMPMPMEPTEEEAKDIYHLNLDDVESYGIALTGRSPGVGFAMVVKAKDGKVDAVKASVDKVLEDRIGAAFYPDEKDVAEKAKVEVDGNFVSLLIFNDDVAAEATQVYKDAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BN76</accession>
    <name>A0A174BN76_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02521">
        <property type="protein sequence ID" value="CUO02521"/>
        <property type="gene ID" value="ERS852471_00836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="36" mass="3812" checksum="95F99E74A9A4C0E1" modified="2016-09-07" version="1">MTGTSIIFFALGAVVLWGGLITTLTITIKNERKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNC0</accession>
    <name>A0A174BNC0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper-sensing transcriptional repressor CsoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csoR_1</name>
        <name evidence="1" type="ORF">ERS852471_00837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264230.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02571">
        <property type="protein sequence ID" value="CUO02571"/>
        <property type="gene ID" value="ERS852471_00837"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO02571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="86" mass="9925" checksum="719184A8FA9E52EA" modified="2016-09-07" version="1">MDERKNAIQSLKVAKGQIEGIINMIEDERYCVDISNQIIAVQSLLKKANMQILRRHINHCVSDAILENKGEEKIDEIMKIFEKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPN0</accession>
    <name>A0A174BPN0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264195.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01516">
        <property type="protein sequence ID" value="CUO01516"/>
        <property type="gene ID" value="ERS852471_00817"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO01516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="65" mass="7212" checksum="8833BA414DB9E4D6" modified="2016-09-07" version="1">MEKKFIRKKAYVDKTYCVACGICEKACPFNAITIYKGIYSKVDFDKCVGCSKCAKACPASTIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQC6</accession>
    <name>A0A174BQC6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="10">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycogen branching enzyme</fullName>
            <shortName evidence="10">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">glgB_1</name>
        <name evidence="10" type="synonym">glgB</name>
        <name evidence="13" type="ORF">ERS852471_00842</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02827">
        <property type="protein sequence ID" value="CUO02827"/>
        <property type="gene ID" value="ERS852471_00842"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="202"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO02827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="678" mass="79410" checksum="4BD6FB75BC1F8ACA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BTK5</accession>
    <name>A0A174BTK5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264292.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04441">
        <property type="protein sequence ID" value="CUO04441"/>
        <property type="gene ID" value="ERS852471_00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO04441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="82" mass="9407" checksum="52E449283D726BD5" modified="2016-09-07" version="1">MWIRVQDEKTLVEPKIIEITKGILKKSKYTIVGKVTNSTQEMVVNLGTYDSEEIADRVFEEIEQAILSDKKIYVVPESNGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BV63</accession>
    <name>A0A174BV63_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lipA</name>
        <name evidence="4" type="ORF">ERS852471_00856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03535">
        <property type="protein sequence ID" value="CUO03535"/>
        <property type="gene ID" value="ERS852471_00856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="95"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO03535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="331" mass="37223" checksum="A44B1B66BC885EEB" modified="2016-09-07" version="1">MKEKLENRKSLLIPALAVVGTITTIAAVNKITVKPASKFIRLLFNGIYPGPKNYDDIKKLTTVKKDIDYGSNIENGIMDINMPLDNSNKKKPLIILLHGGGFIGGSKEATAAYARTLSSYGYIVANVDYAFAPEHVYPTPIIQVSKAITYLKDNKERFNIDDNNIFIAGGSAGAQIASQIAAIQTNKELANIMGIKPVLDKKELKGVILFCGLYNMRNVSETGFPGIKEYLWAYTGEKNFETYKRLDEISTIHHITEDYPPTFITAGDMDKLESQSKEMVKILKDKGVQCTSVFFKDKRLVHQYQFMLWTNEALRTLEKVVYFINQRVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BXI8</accession>
    <name>A0A174BXI8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pepV_1</name>
        <name evidence="4" type="ORF">ERS852471_00871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.13.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264288.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04350">
        <property type="protein sequence ID" value="CUO04350"/>
        <property type="gene ID" value="ERS852471_00871"/>
    </dbReference>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO04350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="467" mass="51313" checksum="F124E50C4B5EAD8C" modified="2016-09-07" version="1">MYKRQIEEYFNLHKDEMLEDICKIIRIKSDRQEPKENMPFGEGVLKALEESLKIASNMGFKTTNYDNYVGAVDFNDKEKALDILAHLDVVPAGDEWTVTEPYEPVIKDGKLYGRGSADDKGPAIVALYALKAVKDLNIPLSKNVRLILGTDEECGSGDIKHYYKIEKEAPMTFSPDADFPVINVEKGGLKGLFNASYSESKEIPRILSVNSGVKINVIPDKATAVIEGFKKEEMEKYCKKATESTGVKFVVSESDNNCVINAKGVGGHAAHPTGGNNALTAIIQLLASMPFAKSEGFERICAINKLLPHGDYYGEALGVKMSDKVSGELTLSFNIFEYSTTGLKGTFDCRAPLCANDENLRDVVAKNLKINGIELEPCNVSDGHYVDENSDFIQTLLRCYEMYSGKKGECIAIGGGTYVHRLKNGVAFGCTMPGTDNNMHGNDEFAVVDELLLSAKIFTQAIIELCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4S2</accession>
    <name>A0A174C4S2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264342.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06706">
        <property type="protein sequence ID" value="CUO06706"/>
        <property type="gene ID" value="ERS852471_00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018898" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO06706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="124" mass="13899" checksum="BF906FA28FD30D3C" modified="2016-09-07" version="1">MKKVIAGTLITAMVSNNLAYADTIKNEFLEVSDNTEVIESVEELLENNENETQLGTDKTETNFEYELAEKKESVDTAQSVEKTTVKTDIDVFDYNQLKNAVMQSNVNINIKNDISFDNPINITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C754</accession>
    <name>A0A174C754_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">ERS852471_00915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264393.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08109">
        <property type="protein sequence ID" value="CUO08109"/>
        <property type="gene ID" value="ERS852471_00915"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2024128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019014" description="Protein-export membrane protein SecG" evidence="10">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO08109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="76" mass="8216" checksum="1DBC0F12D38CB845" modified="2016-09-07" version="1">MKSFLFVLEAVLGLIVVVSILMQKSKADALSGLIQGSKSETFFAKNKAKTKEAMLAKITIISMLLFAINTVALNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9G3</accession>
    <name>A0A174C9G3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="8">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ddl_2</name>
        <name evidence="8" type="synonym">ddl</name>
        <name evidence="12" type="ORF">ERS852471_00954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10132">
        <property type="protein sequence ID" value="CUO10132"/>
        <property type="gene ID" value="ERS852471_00954"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="100"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="306" mass="33859" checksum="526D0A7B807EFEB0" modified="2016-09-07" version="1">MIKVGVIMGGISSEREVSLKSGNSIVENIDRSKYEVVPIVIDNKDDIINKVKGIDFALLALHGKFGEDGTVQSVLQTLDIPYSGCGPISSGVCMDKDLTKRILVANGIRTARWINVSSIEEIDYDKIEEMGYPVFVKPTNGGSSVATFKITKKEDIENAVLEGLKWDTEVMIEEFIKGDEITCPVFDKKMWPVIAIRPKEGADFFDFTQKYSEDGAEEVIVELEENLHKEVEKMAIGTYRALKCEVYARVDMIVTSEGVPYILEVNTLPGMTAASLFPRSANAVNVSYSGLIDMIIQTSLKVKRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CA58</accession>
    <name>A0A174CA58_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264465.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10034">
        <property type="protein sequence ID" value="CUO10034"/>
        <property type="gene ID" value="ERS852471_00952"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1745385at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO10034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="340" mass="39138" checksum="506A81B98290271A" modified="2016-09-07" version="1">MNDVLYLSKLEFSKMFKSKIAKVGIILSFIIMIGLTISEYSDMKRVREYESTNGTSTTFDWREREEYLISQKDVMLSDPYYDEIQKDEINKRIEIAEYRLEHNITKDYEKNIWWFFADNSFNWVFRFIILTVVLVGVFNVASEYNNKTINMWLVSPYKRWKVLTSKYLAILIYGLEILGIVLVMGLLSGIIIHGFDRISSQTILYGVNGPYVISTALYSVIIVLLKLVELIFSIALAFMIAVLLKSVSFATITSIITIFLVSPVVLYAGKMSRLINYLPFNHLDFRKFLDYGTVLPQINNDFQSIVIQGFTPVIAALIVGAYIALFMAITYGVFCKRDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CI31</accession>
    <name>A0A174CI31_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ifcA_1</name>
        <name evidence="6" type="ORF">ERS852471_01002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12577">
        <property type="protein sequence ID" value="CUO12577"/>
        <property type="gene ID" value="ERS852471_01002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019192" evidence="4">
        <location>
            <begin position="28"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="584"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="660" mass="70795" checksum="EA6E779AC8826C9B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJ88</accession>
    <name>A0A174CJ88_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urocanate reductase</fullName>
            <ecNumber evidence="3">1.3.99.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ifcA_2</name>
        <name evidence="5" type="ORF">ERS852471_01018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>A + dihydrourocanate = AH2 + urocanate</text>
            <dbReference type="Rhea" id="RHEA:36059"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27247"/>
            <dbReference type="ChEBI" id="CHEBI:72991"/>
            <dbReference type="EC" id="1.3.99.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.33" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13422">
        <property type="protein sequence ID" value="CUO13422"/>
        <property type="gene ID" value="ERS852471_01018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="1 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022272971" description="Urocanate reductase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="602" mass="64029" checksum="543E2EDAB33D032B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUN8</accession>
    <name>A0A174CUN8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15809">
        <property type="protein sequence ID" value="CUO15809"/>
        <property type="gene ID" value="ERS852471_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010178">
        <property type="entry name" value="Integral_membrane_1906"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07314">
        <property type="entry name" value="DUF1461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01906">
        <property type="entry name" value="integ_TIGR01906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="242" mass="27993" checksum="DB30AD6C13C9ABE1" modified="2016-09-07" version="1">MGKSNVNIIKKEKSIIKNLAKCAWIIYSSIAAICIAAVTIINSTWIYKLVVKKYDLTTITGLSEQALMMEYGGLINYLQNPFIDKLEFDNFVMSTYGEVHFYEVKKIFIALMVIIAVFIMALAGWFIFNKYKKGSINIRGLLRNFNNSANLLIIFFIGIVVLYFIDFSWAFTMFHKLFFRNDYWIFDPRIDPIIIALPEELFMICGGAILILLVIMIIAVKWGYYRNRNNIKSYSENSAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CY01</accession>
    <name>A0A174CY01_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264590.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16628">
        <property type="protein sequence ID" value="CUO16628"/>
        <property type="gene ID" value="ERS852471_01056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO16628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="9909" checksum="4F7C8A1C96850FFB" modified="2016-09-07" version="1">MRNNKIEKIYEVIKTNGRALNLHEIKAMTGAGNGYAAQNTIKSSDINNSYITESCNHKSKKINELLNTAGMKLNLHQIKAMTGAGNGYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5D0</accession>
    <name>A0A174D5D0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yehT</name>
        <name evidence="8" type="ORF">ERS852471_01137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264656.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20663">
        <property type="protein sequence ID" value="CUO20663"/>
        <property type="gene ID" value="ERS852471_01137"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO20663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="240" mass="28753" checksum="B1B521916FDBF37B" modified="2016-09-07" version="1">MIKFAICEDEIIQAEINQDYIKRWADKNNIEYKIDIFESAEKFLFSWQYEEVYDVIILDIRMKSMSGMELARNIRLKDSDVIIIFISGIDDYVFDGYNVAAFNYLLKPINDEKIFNVLDRVKEKLEKDKNAKQFLLLSKGKNIFKIDYDDIFYIIAFDHYIDIHSKNEIYTFNRKISQLEELLPKENFVRCHRSYIVNIKYVKNINKNSLLLEDDIKIPISKTRMDNTYNTFINYFAKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7N4</accession>
    <name>A0A174D7N4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264670.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21544">
        <property type="protein sequence ID" value="CUO21544"/>
        <property type="gene ID" value="ERS852471_01154"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO21544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="159" mass="18089" checksum="11AAE32233EA53C3" modified="2016-09-07" version="1">MEFPMHIVAAGALVTNERGEVLLVKNPYRGWEFPGGQIENGEDLIEGVTREVFEESGIIIKVDNLVGVYSNTKSYLGWDNETIVPTKVIFDFLATAEGGALKCSEESVEVGWFEKDKVLNMITEPWLLDRAEDMLKFNGEIVYRVYSSRPYEIFRETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DHP8</accession>
    <name>A0A174DHP8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264709.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23516">
        <property type="protein sequence ID" value="CUO23516"/>
        <property type="gene ID" value="ERS852471_01198"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1954854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="75" mass="8765" checksum="A2BC8D5ABB8B50C7" modified="2016-09-07" version="1">MDAYQLIGLLQRKMQDPRFASKFNQLADELNSIPGLQQKVMQIVQIDNEKKRQKELDKLPARAKAIVKELLEMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMF4</accession>
    <name>A0A174DMF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgA_1</name>
        <name evidence="3" type="ORF">ERS852471_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264729.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25275">
        <property type="protein sequence ID" value="CUO25275"/>
        <property type="gene ID" value="ERS852471_01210"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO25275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="372" mass="42448" checksum="511034357D91C0B3" modified="2016-09-07" version="1">MKIAMIGQKGIPSRAGGVEVHVEEIAAGLCEKDVQVDVYARKSYCDEINDKYRGINIKYIPSINTKSLDAITYTFLATIYALFLGYDVIHYHALGPSSMAWLPRLFGIKVVCTVHGLDWQREKWGRFGKLYLKFGEFIIAKFANEIIVLTNSMKKYFKEKWNRDSTVISNGVYIGKDIDANIITEKYNLTKDSYILFLARLVPEKGAHYLINAYKKLKTDKKLVIVGGSSYTDDYVNSLYKLADSDNNIIFTGFVKGKELEELYSNAYVYVLPSEIEGLPISLLEALSYGNCCIASDIDEICETMKEYGLYFKKGSEEMLSKVLYEVLNNKSLVARYKDTSKDFVLSEYNWKDKVVDTLEVYNKCVSIDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E279</accession>
    <name>A0A174E279_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
            <ecNumber evidence="2">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycdX</name>
        <name evidence="2" type="ORF">ERS852471_01352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264969.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31794">
        <property type="protein sequence ID" value="CUO31794"/>
        <property type="gene ID" value="ERS852471_01352"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="243" mass="27034" checksum="2341DAB20594AAC6" modified="2016-09-07" version="1">MNYSSDLHTHTIVSGHAYSTLLENIDHCSKNGIKILGTSEHGPKMPGAPHYWYFGNLKAVPRVINNVTILKGCEANILDVDGNLDMPKDLTTCLDYMIASFHEPLFPMTLSKEEKTSAILNTLDKNEKVEILGHLGNPNYVLDYETVVKKAKEKNIMIEINNSSLMGSSRKGSDVNCETIARLCKKHGTKVILTSDAHINTAIGNFEKGIELFKKIEMPEELIMNDPDKLIAHLKSKGRLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5T6</accession>
    <name>A0A174E5T6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nfo</name>
        <name evidence="9" type="ORF">ERS852471_01342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264951.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31380">
        <property type="protein sequence ID" value="CUO31380"/>
        <property type="gene ID" value="ERS852471_01342"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO31380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="278" mass="31470" checksum="274D621ABF0D4B9F" modified="2016-09-07" version="1">MLKIGCHLSTTKGFENMGKEALKIGANTFQFFTRNPRGGKAKDIDQKDIDAFLKLANDNNFGVLLAHAPYTLNACSADENTRKFAKEMMADDLIRMEYIPNNLYNFHPGSHVKQGAEVGINYIVDLLNEVIKPEQTTTILLETMAGKGTEVGRSFEEIAEIISRVNLKDHMGVCLDTCHVYDAGYDIVNDLDRVLDEFDRIIGLDKLKAIHLNDSKNPFKSHKDRHEKIGEGFIGFEGIKRIINHPKLRHLPFFLETPNELDGYAKEIELLKSVYEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E8W1</accession>
    <name>A0A174E8W1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ORF">ERS852471_01378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265021.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34103">
        <property type="protein sequence ID" value="CUO34103"/>
        <property type="gene ID" value="ERS852471_01378"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="159" mass="17246" checksum="916F75EE970F2F12" modified="2016-09-07" version="1">MKVAIFFGSKSDTEVMRGAATALKEFGVEYKAFILSAHRVPEKLEETLREIEKEGYEVIIAGAGLAAHLPGVIASQTVLPVIGVPVKAALDGMDALLSIVQMPKSIPVATVGINNSYNAGMLAVQMLSLKYPDIKEKLIEFRINMKKKFIEENGQGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFV3</accession>
    <name>A0A174EFV3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fer_1</name>
        <name evidence="6" type="ORF">ERS852471_01426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265097.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36157">
        <property type="protein sequence ID" value="CUO36157"/>
        <property type="gene ID" value="ERS852471_01426"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO36157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="6473" checksum="2ED16EC10C9743DC" modified="2016-09-07" version="1">MKANVDQETCIGCGMCPSICPEVFDMNDDGKAHTIVDEVPAGKEDEAQDAANSCPVSAISVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENW3</accession>
    <name>A0A174ENW3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF3783)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265178.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38179">
        <property type="protein sequence ID" value="CUO38179"/>
        <property type="gene ID" value="ERS852471_01472"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014661at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014543">
        <property type="entry name" value="UCP014543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO38179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="14183" checksum="6F9B3142C0CA0B18" modified="2016-09-07" version="1">MLDNNKCILAYGLTNDELEWLNEFNYKVINVLPDMCEMTLKEVLDGLRFEIINNNPIKEKAIIYNNFPESELREAIALTRTKIKGGVLAMVTPNSINWTFNYLINHLIEEREWHLRNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ52</accession>
    <name>A0A174EZ52_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5658 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265254.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41255">
        <property type="protein sequence ID" value="CUO41255"/>
        <property type="gene ID" value="ERS852471_01511"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2205469at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043717">
        <property type="entry name" value="DUF5658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18902">
        <property type="entry name" value="DUF5658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5658" evidence="2">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="122" mass="14681" checksum="3ABD219E7A4DF2B2" modified="2016-09-07" version="1">MFFKSNYLKENKYHKLKINLIILYLLNLSDLFFTKLLLKLEPTMFIEANVFLAPVIDGVLPYFFKIVVIAVILYYWYFRSRYSNEKEIKRSLIASIGLVSFYMLINLLHLFNVGFMILNWQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F017</accession>
    <name>A0A174F017_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ChW repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265328.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43051">
        <property type="protein sequence ID" value="CUO43051"/>
        <property type="gene ID" value="ERS852471_01549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006637">
        <property type="entry name" value="ChW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07538">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00728">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="37346" checksum="61C69114BFF2D771" modified="2016-09-07" version="1">MKKVIKIFMSIFILNMMLTNVFITEVKSENREILNFITVDEGISSIRGNLEGLALILKNGETRFIKNGQVIILNGTNYHSISNEIMVNENNLVFNINNGDYLSKQDGENLLSYVNNIKKSLYLNPDDNIYLIQDYFVVINKKDEKYNVKYYNVENDNFIIKKEVNDIEAEYIAFDEEGKIVVLKDSIVSIYEEDSKVELFKVPEGYQLNYIDKNNYILFNENEYAIVNSYEEKEVITDKEYLVVDRKTTVINNEVLSEMPLSVSYATHVQGYGWQEWKRDEQMTGTSGESKRLEGIKINVEGLPEGVSVVYRTHVQSYGWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2V1</accession>
    <name>A0A174F2V1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall binding repeat-containing protein /mannosyl-glycoprotein endo-beta-N-acetylglucosamidase domain-containing protein</fullName>
            <ecNumber evidence="3">3.2.1.96</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lytB</name>
        <name evidence="3" type="ORF">ERS852471_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265330.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43099">
        <property type="protein sequence ID" value="CUO43099"/>
        <property type="gene ID" value="ERS852471_01550"/>
    </dbReference>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006637">
        <property type="entry name" value="ChW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07538">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00728">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021282" evidence="1">
        <location>
            <begin position="29"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="437"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO43099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="951" mass="106303" checksum="BA50A7F9D2E47459" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4S8</accession>
    <name>A0A174F4S8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbX</name>
        <name evidence="8" type="ORF">ERS852471_01562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265356.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43816">
        <property type="protein sequence ID" value="CUO43816"/>
        <property type="gene ID" value="ERS852471_01562"/>
    </dbReference>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="326"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO43816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="485" mass="55978" checksum="7BCC2920B3E8A7F8" modified="2016-09-07" version="1">MEKSVGKNIAFKFILNIFNIGIPIFLGPYIIRTLGAEMLGNINFAQSVFGYFFIFANFGVYQFAVRELSRIREDKERLSIIFTNLFCVTTLTTIITLVGYLITVNKVYSNDKELYLIFIIMSSNFISNIFYIEWANEALENYDFITIKTMAIKIIYLIIVFCVIKKKCDFTLYVKLMVLSTFFNNIVSYVYIKRKIKFNFKNLFFLKYIKPMFLGVLISNANVLFTQLDIILLGQVISKTDVAFYSTANSIMIMINTMMISIITVTLPRISNYLGNNDNVKYIDMVNKIVKLFFMILIPTAVGIFILSDRIMFLYGGIEFENTGNLLRIFAIYMLTIGVDYILANQVIYIQRKEKSLIKMLFVSGILNLVCKVLLIVSGMFNIYTAIGTTLIANIILILLEYYYVRKKMLVNISLFNKDILKYSILSLGFIVISIGIKVLNINWMITMILIIMLCSTLYFSVLIFTKDENIILILKSIRILPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLV7</accession>
    <name>A0A174FLV7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">guaB_1</name>
        <name evidence="3" type="ORF">ERS852471_01662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265546.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49549">
        <property type="protein sequence ID" value="CUO49549"/>
        <property type="gene ID" value="ERS852471_01662"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="139" mass="15925" checksum="4FC32D3473EDE313" modified="2016-09-07" version="1">MNIAFLLTPKNEVIYEYLDATMRQVMERMDHHGYTAIPLIDRNGKYVGTLTEGDLLRKLKSTPDLNFKNTGTIKINEIPRRKKHKSVSINADVESIINLATTQNFVPVIDDNGIFIGIIKRSDIINYCYNIIRKEKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWK1</accession>
    <name>A0A174FWK1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Veg protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53248">
        <property type="protein sequence ID" value="CUO53248"/>
        <property type="gene ID" value="ERS852471_01741"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971787at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009366">
        <property type="entry name" value="Protein_Veg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40026">
        <property type="entry name" value="PTHR40026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06257">
        <property type="entry name" value="VEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037257">
        <property type="entry name" value="DUF1021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="8818" checksum="E482EDC1CA39C8C1" modified="2016-09-07" version="1">MELNKTIATIKKDIQNHLGEKVTLKANGGRKKILVNDGVIESVHPSIFVVRLENDTQRTVTYSYSDVLTKTVLLYYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GB99</accession>
    <name>A0A174GB99_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD_2</name>
        <name evidence="5" type="ORF">ERS852471_01839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265873.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58907">
        <property type="protein sequence ID" value="CUO58907"/>
        <property type="gene ID" value="ERS852471_01839"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO58907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="34168" checksum="37D1831A03631226" modified="2016-09-07" version="1">MEEIILKVTEENTGERIDKYLSTVIEGKTRSFIQGLIEEKAVTVNGKIIKSNYKVKINDEVVVILPEPIELDVKAENIKLDIVYEDSDVIVVNKPKNMVVHPAPGNYSGTLVNGLLYHCKDLSGINGVIRPGIVHRIDKDTTGILVVAKNDEAHNSLAKQFKDHSIKREYYALVEGRFSKESGTIDKPLGRNKKDRLKMDIVEDGRRAVTHYEVLEQYDKGVSLIKCTLETGRTHQIRVHMASIGHPLVGDQTYGFKKQKFKIEGQALHAKTLGFIHPSTGEYIEFTSDLPEYFEELIRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKD4</accession>
    <name>A0A174GKD4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium uptake protein, TrkH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ktrB</name>
        <name evidence="10" type="ORF">ERS852471_01886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265956.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60895">
        <property type="protein sequence ID" value="CUO60895"/>
        <property type="gene ID" value="ERS852471_01886"/>
    </dbReference>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO60895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="448" mass="48551" checksum="6714F37D22E27A89" modified="2016-09-07" version="1">MQFNLRKSNKLKGVQILALGFLVVILIGAIILTLPISSATRQYTNFLDALFTSTSAVCVTGLVTLDTGTHWSMFGQTIIMLLIEIGGLGFMSFTTLIAIILGKKITLRDRLILQDAMNTFNIQGLVKMVQYVLTFTITVQLSGALLFSTQFIPKYGIGKGMFYSLFHSISAFCNAGFDLFGNFSSLTSYSSNWVVILVASALIIIGGIGFAVWIEVYNFKSMKKLSIHSKMVILVTAILVVGGTILMFIFEHNNPNTLANMNIGDKLVNSFFAAVTPRTAGFNSISTDGMTNAGNLLTIILMFIGGSPGSTAGGIKTTTIGVLIVTVICVIRGREDAEAFKKRFPKELVYKAFTLFFIGGVLVMSATMLLSYTEQGASFLSLLYETTSAFATVGLTVGLTQQLTEVGKVLIMIMMYLGRVGPLTVVLSLMRNKKNNGVKYPEGKILIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GL15</accession>
    <name>A0A174GL15_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">asd_2</name>
        <name evidence="12" type="synonym">asd</name>
        <name evidence="14" type="ORF">ERS852471_01892</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265964.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61135">
        <property type="protein sequence ID" value="CUO61135"/>
        <property type="gene ID" value="ERS852471_01892"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="327" mass="36420" checksum="D9BF131414DEC82E" modified="2016-09-07" version="1">MYNIAIVGATGNVGRKFLSILEERNFPINQLYLFASKKSNGTHLKFRGNSYLVQETSENNIKDKKIDYALFSAGGDASLYFAPLFTKYGAIVIDNSNAWRMNDDVPLVVPEVNPEDLKNHKGIIANPNCSTIQAMIPLKALKDNYGLKRIIYSTYQAVSGAGIGGINDLKNGASGITPTKFPYQIFNNCIPQIDVFLDNGYTKEEIKMINETKKILHDNDLKITATTVRVPVLNCHSESINVELLNSYNLDDIITIFNNTSGLTVYDEKESLKYPMPIIVDGEDNVFVGRIRRDFSIENGLNLWVVGDNLRKGAALNAVQILETLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLI0</accession>
    <name>A0A174GLI0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="13" type="ORF">ERS852471_01908</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265988.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61810">
        <property type="protein sequence ID" value="CUO61810"/>
        <property type="gene ID" value="ERS852471_01908"/>
    </dbReference>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="610"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="817"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="527"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO61810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="880" mass="100698" checksum="AF00009E88F5FDF2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GN24</accession>
    <name>A0A174GN24_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase/N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266030.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63371">
        <property type="protein sequence ID" value="CUO63371"/>
        <property type="gene ID" value="ERS852471_01927"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1243507at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="224" mass="24164" checksum="0A945983031BB94E" modified="2016-09-07" version="1">MENKRIKNVPEIKGILRSHVVEVPPCIRDCSGIKIFGKRIKSLLFTTDVAIIRNTNADAIIAVYPFTPQPLITQALVMAADVPIFCGVGGGITQGKRVVNLALDAEFKGAMGVVVNAPTSNEILRKIRETIDIPVIVTVVSECEDIKARIEAGATILNVSGGKNTAKIVRKIREEFPDFPVMATGGPTEKTIKETIEAGANAITYTPQSTGDVMSELMDKYRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU31</accession>
    <name>A0A174GU31_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbamoyl phosphate synthase-like protein</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266191.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64598">
        <property type="protein sequence ID" value="CUO64598"/>
        <property type="gene ID" value="ERS852471_01957"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="122"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="36769" checksum="435B624432AA6102" modified="2016-09-07" version="1">MNINILILSAGRRVELVKCFKDAANSLKINSNIITADISKTAPAIYFGDKNYIIPRIGEENYIDSIIDICKEEEIKLIVPTIDTELSILSQNKELIEEITEAKVLISSREVINICRNKINTSMFFEKNGFGIPRLINDYNLSAGNYKFPLFIKPLDGSSSINTFKINNRLQLDFFIKYVKNPIIQEFIEGKEYTIDAFIDFDGNPITIVPRERIATRSGEISKGKIVKDRDLIEEIKEVISVLKPIGHITFQCMKTREGIKFIEINPRFGGGAPMTIKAGANSPMNLYKLLMGEKLTYNEDYEDNMIALRFDDSIFINSEGQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUR2</accession>
    <name>A0A174GUR2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ywqD_3</name>
        <name evidence="10" type="ORF">ERS852471_01956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266084.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64559">
        <property type="protein sequence ID" value="CUO64559"/>
        <property type="gene ID" value="ERS852471_01956"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO64559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="25557" checksum="D7312939E9EBADA9" modified="2016-09-07" version="1">MLVVNKLPRSLSAEAYKALRTNIKYASVDKKLQTIVVTSSQPGEGKSTVAGNLAYTLSKDGARVLLMDCDLRKPTLHKKLDLINEKGVTDFLVHKCDIKLSIHEVEDNLFVMPSGSRVPNPSEILGSRAMEEFLNDLKRAYDYIILDTPPVIPVTDGLILAGKADGTILVARSRKTQERILKQSYRDLTNIGANIIGSVLTDLENTRYDKYHEYYGTGRMGFRNRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUT0</accession>
    <name>A0A174GUT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular polysaccharide biosynthsis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266094.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64836">
        <property type="protein sequence ID" value="CUO64836"/>
        <property type="gene ID" value="ERS852471_01963"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="215"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="398" mass="46427" checksum="422B5EAA430B4929" modified="2016-09-07" version="1">MKKRVIIVADSLEIGGIERSLISMMDNFDYDNYQVDLMLYQKSGELLENLDKRVNLLESQNRCKTFGIPVKELIKKGNLLMASGRIIANILAKCISKIRNIEDIGYYQTQLMYKFTHFLLKREKQNYDIAIGYVWPHDYILKKVNSKVKIGWIHTDYSTIDINRKIDEKMWSKLDYIISISDECTRAFEKIYPNLKEKIILVENITSPQFINNKSKEKLELNINDKYFNIISVGRICYQKGFDIAVQVLAEVHSRGYKNIRWNIIGFGPDEEKIRELIKKYNVEDSFILHGKKVNPYPYIAKCDLYVQPSRYEGKAVTINEAKILGKAIIITNYSTASSQIENMVDGIITELDIDKITDSIINLYKDKELRISLEKNCRNKSYENSKELLKLYKVMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWA9</accession>
    <name>A0A174GWA9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ywqF_3</name>
        <name evidence="12" type="ORF">ERS852471_01970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65130">
        <property type="protein sequence ID" value="CUO65130"/>
        <property type="gene ID" value="ERS852471_01970"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="275"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="211"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        </ligand>
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        </ligand>
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            <name>substrate</name>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">2789STDY5834856</strain>
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    </reference>
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        </subcellularLocation>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H176</accession>
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            <fullName evidence="2">Protein RecA</fullName>
        </recommendedName>
    </protein>
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    </gene>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO68563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="61" mass="6557" checksum="946E31F7F971AE7B" modified="2016-09-07" version="1">MNIDDNKLKVLENVMSQIEKQFGKGAIVKLGGQSSMDVESISTGSLALDIALGVGEYQKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3W1</accession>
    <name>A0A174H3W1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system beta-glucoside-specific EIIBCA component BglP</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">bglP2</name>
        <name evidence="16" type="ORF">ERS852471_02027</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266226.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67928">
        <property type="protein sequence ID" value="CUO67928"/>
        <property type="gene ID" value="ERS852471_02027"/>
    </dbReference>
    <dbReference type="OrthoDB" id="328780at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011297">
        <property type="entry name" value="PTS_IIABC_b_glu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01995">
        <property type="entry name" value="PTS-II-ABC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="103"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="478"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO67928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="608" mass="64662" checksum="600DC9EDB651B9EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HA87</accession>
    <name>A0A174HA87_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication restart DNA helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266387.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71832">
        <property type="protein sequence ID" value="CUO71832"/>
        <property type="gene ID" value="ERS852471_02119"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1472466at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="355" mass="40633" checksum="177EB54BDFBD5897" modified="2016-09-07" version="1">MGAAVYKCPNCGAHVTFDAQSQKGKCDYCLSTFSIQELEDYLKKEDDRSDEYSEEQISDELRDEINNNTRVYKCPRCGAEVVADKSTAATFCYYCHGPVILTDKLSGDFKPSKVIPFKIDKRKAEEILLNWSKKKWFIPKEFTSAKQLEKITGIYIPYWLFDCDVDGSMMAIGKKIMTWRQGDYEYTKTDTYEVYREAKLKFDNVPHNASSKADDKVMTAIEPFDYNEIKDFSMAYLPGFLADKYDRTKEDVLPSIKSTINNSVNNILRNSINGYSIVSERNFNSKYSNAKFKYALFPVWMLTYQFNNKNYIFAINGQSGEVYGALPVSKGRIGILFTILFVISFIVALIGGMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAD3</accession>
    <name>A0A174HAD3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266320.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70090">
        <property type="protein sequence ID" value="CUO70090"/>
        <property type="gene ID" value="ERS852471_02085"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="31547" checksum="DD5ECDDCEA6419D3" modified="2016-09-07" version="1">MIRIVSDSSSLYSKKDGQAKGIEIAPLSVTINNNTYKEYEDIQTEEFIDIINEGHIPSSSQPSIGEVLEIYSKYPQDEIINISMADGLSGTYNSACMARNMDENPERIHVINSQTLCGPQRYLVDLATTLAQNGIEAKKIVEEINETLDKSKSFLIPNDFDYLVRSGRLSPLVGKIGGLIKLVPVMTLAEDKKSLVKFTTKRTFKRAIQRICEEMIEDKVDSDCKIYITHACKEELAEEAKKIILGNIENADIEVKLLGPAFTTQGGPGCVAIQYIRKHEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGY1</accession>
    <name>A0A174HGY1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266464.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73491">
        <property type="protein sequence ID" value="CUO73491"/>
        <property type="gene ID" value="ERS852471_02159"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO73491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="243" mass="28095" checksum="F3D403ECCD887D54" modified="2016-09-07" version="1">MFKNFEENIYGEEIERIYLSFFSNKLRVGVIGGGKAAIIKIRSFLKRNVYVEVLSREFSEDILNIRDKNLRLIKSDYKSDFIQDKHIIVIAINDNELLQRIKDECDEAYKLYINCSDFKDGIAAMPVQRNLKNISFGINTVGGNPRGALMVADIAYKSLCSIDDFIGFITRLRNNAKVLGNHKKEVIEFLNSNDFKFFYDKGKDKTVFKLFLEDEDLQCLYRGEINGDSYSNKKEYFSSSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNZ7</accession>
    <name>A0A174HNZ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cadmium efflux system accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ziaR</name>
        <name evidence="2" type="ORF">ERS852471_02249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266612.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76624">
        <property type="protein sequence ID" value="CUO76624"/>
        <property type="gene ID" value="ERS852471_02249"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="118" mass="13750" checksum="D26D94B82062C2AB" modified="2016-09-07" version="1">MEEKNESCLCNVIHKDVVEEVRDKLPKEETLYELAEFFKVFGDTTRIRILCALFEAEMCVCDLSALLNISQSAISHQLRGLKAARIVKFRREGKVVYYSLDDEHIKHIFDEGFRHISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HP27</accession>
    <name>A0A174HP27_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system mannose/fructose/sorbose family transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">manX_2</name>
        <name evidence="10" type="ORF">ERS852471_02250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266614.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76654">
        <property type="protein sequence ID" value="CUO76654"/>
        <property type="gene ID" value="ERS852471_02250"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2008912at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013789">
        <property type="entry name" value="PTS_EIIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00824">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO76654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="141" mass="15548" checksum="8825F60191A566C5" modified="2016-09-07" version="1">MVSLIIGTHGSFSRELINSAELIYGKLENVNYITFLPGEGQKDLIDKYNTIINKLDKDSEVLFLVDLFGGSPFNTASMLSIDNVNMDVVTGVNLPMLLEVYSNIDNSSLEELVSIAVNSAQKSICSLKKSIDLNREDDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I268</accession>
    <name>A0A174I268_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subtilase family protein</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aprX</name>
        <name evidence="6" type="ORF">ERS852471_02333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266751.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80016">
        <property type="protein sequence ID" value="CUO80016"/>
        <property type="gene ID" value="ERS852471_02333"/>
    </dbReference>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="108"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO80016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="43525" checksum="D862F2A6FAA30088" modified="2016-09-07" version="1">MFSLNKKLDSNLKNYMEFNTSRSYRVLIKCRNFQDSIEKRILSYKGTILRNINIDNIICAILNSQSINRLLEYPEVEYICLDQFFNLCGISVQTANRVRLSNSINASGRGVGIGVIDSGVYPHRDLTTPFNRIATFTDLINGLSFPYDDNGHGTCTCGVIAGNGESSNGIYKGIAPNSELHVIKAFDRLGKGYVSDVLYAINELISISPKYNIKILCLPFESLNHDKFIFSLFDKILKKAVDLGITPILPSGSNSIEGSIMGIALSKNAITVSGLDTTSKTTPYEYSSTGAPKKDFKPNFCAACVDIVSLNCNTSYISEKNNTKIYAPKLSSSYKSFSGTSISAAYISGICALLYELTPTLSFDDIVSMLTASSTNLDLPLNTQGEGCINLNKLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I5L7</accession>
    <name>A0A174I5L7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hybrid cluster protein-associated redox disulfide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266765.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80345">
        <property type="protein sequence ID" value="CUO80345"/>
        <property type="gene ID" value="ERS852471_02348"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1961381at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO80345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="60" mass="6446" checksum="B80A885C08A7F030" modified="2016-09-07" version="1">MITKEMTIGEVIKANVNKADVLMQFGMGCVGCPSAQAETVEEAARVHGIDLNELLDALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I5T2</accession>
    <name>A0A174I5T2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhhX_2</name>
        <name evidence="3" type="ORF">ERS852471_02392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266850.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82512">
        <property type="protein sequence ID" value="CUO82512"/>
        <property type="gene ID" value="ERS852471_02392"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1840839at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO82512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="338" mass="39849" checksum="EB529FAB753CC027" modified="2016-09-07" version="1">MLTIGYIGNGKSTNRYHLPFVLQRDSIKVKTIYQRNPKNESWDRIEGVKYTSNLNEVLNDEEIQLIVVCTRHDSHYEYAKLALEHNKHCLVEKPFMETSEEAKEIFKLAKEKGLIVQAYQNRRFDSDFLTVQKVIESGKLGDLLEVEMHYDYYRPYIPESVDNFIPSSSYLYGHGCHTLDQVISYFGKPDNIHYDVRQLLGKGRMNDYFDLDLYYETLKVSVKSSYFRVKERPSFVVYGKKGCFVKQTKDRQEEHLKLFYMPHNEDFGIDLPEHYGTLTYYDNEGNYHEEKVKSEKGDYGRVYDDLYNAIINGKEKTITDEQTLLQMEMLEQGIKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I8J5</accession>
    <name>A0A174I8J5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266846.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82416">
        <property type="protein sequence ID" value="CUO82416"/>
        <property type="gene ID" value="ERS852471_02390"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1742795at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO82416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="17374" checksum="D75BF9EBE2E2CFED" modified="2016-09-07" version="1">MDYKELLKEDSEIILDSFMNKDAFILGKYISEIAISKNYDVAIRIIKNNNIVFEYLNDNASFNNFYWIEKKINVVKRFDKSSALIAYKLKSENLTFDEKYGDAREYAVTPGAVPIRVKSVGTVGIISVSGLSSEEDHGLIIKGLKYLLSRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I982</accession>
    <name>A0A174I982_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_13</name>
        <name evidence="2" type="ORF">ERS852471_02424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83792">
        <property type="protein sequence ID" value="CUO83792"/>
        <property type="gene ID" value="ERS852471_02424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="358" mass="38717" checksum="674ABAAD7410808D" modified="2016-09-07" version="1">MWSCVIVGIIISLLFFIFMDQILVFIGASSDTIELTRSYLIIVICSGPFVLISNCYSNVLRAEGQSNKAMMGMLIGNLLNIILDPIMILGFGWNITGAAIATVIGNIIGALYYIAYFMKGKSMLSINIKDFTIKDKVCSSVLAIGIPASLGSILMSVSQIIMNSQMASYGDMALAGIGVAMKVTMITGMVCIGLGQGIQPLLGFCVGSKNWDRYKKILKFSLWFALILGVSLTAICYLFTNQIVSTFLTEVSAFDYGVEFSRILLSTSALFGVFYVLINALQATGAAVSSLIINISRQGIIYIPALFILKAILGINGLVWAQPVADILSICLAIILYVITSQKLMKDNVDSKVVLEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ID20</accession>
    <name>A0A174ID20_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmuC_7</name>
        <name evidence="11" type="ORF">ERS852471_02401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266864.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82849">
        <property type="protein sequence ID" value="CUO82849"/>
        <property type="gene ID" value="ERS852471_02401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="12"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="435" mass="47004" checksum="0C903513650EACA9" modified="2016-09-07" version="1">MKEKVGGFGNFIESKLLPVADKFSRQRHLTALRDGMLAYLPFTIISSIFLIIAFLPIPGYSEFMTNLFNDGGAWVGKLVYVTNSTNDVAGFFVLFATAYSLAKSYNVDKLQASLTALAAFLVVTPYISGDAGTAIPMVKVGAQAMFVAFIVAMVSVEIYRRMEQKGIVIKMPDAVPPAVAKPFASLVPAFVTILVFWIVRVIFDVALNSDLFTTINLIIGKPLLLLGGSLGGFVFALLFEQFLWFFGIHGGSIVSSGAMNPIWTMLEDANRVASIAGEAPVNIIGSSFRTAFASIGVVGCVIAMVIVAKSKQYKEVGKVGLVPYCFNIGEPVLFGVPLMLNPIYFIPLVITPAVSSLIAYAALAFKLVPIPTGLAQLPWTTPPIISGYLVTGSISGSILQIVLLVVATLIWLPFVKIADKQIYVEEQKREMEMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IG39</accession>
    <name>A0A174IG39_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ywqN</name>
        <name evidence="2" type="ORF">ERS852471_02428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266910.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83919">
        <property type="protein sequence ID" value="CUO83919"/>
        <property type="gene ID" value="ERS852471_02428"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="180" mass="20075" checksum="D1F952418D8792C1" modified="2016-09-07" version="1">MSKKVLILSSSPRKGGNSDLLCDEFMKGAQESGNYVEKIFIAQKNINYCRGCGVCNSIHKCVQNDDMAEILDKMVSADVIVLATPVYFYSMDGQLKTLIDRTVPRYTEISNKDFYYIMTAADTDKNMLERTIEGLRGFTEDCLSGAKEKGIIYGTGAWEKGEIKNTPAFLQAYEMGKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J2C4</accession>
    <name>A0A174J2C4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pncB</name>
        <name evidence="12" type="ORF">ERS852471_02651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267295.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93912">
        <property type="protein sequence ID" value="CUO93912"/>
        <property type="gene ID" value="ERS852471_02651"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="162"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="370"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO93912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="488" mass="55541" checksum="4850621B558306C7" modified="2016-09-07" version="1">METLIKFDVQNERNLTMLVDFYELTMANGYFNKGVENRIAYFDMYFRRVPDGGGYCIMAGVEQLIQYLSNLKFTSSDIDYLRSKNIFSEEFLEYLEDFKFCCDVWAIPEGNPVFPNEPLVIVRGPVVQAQFVETMILLTINHQTLIATKANRICRAAEGKTVMEFGSRRAQGYDGAIYGARASIIGGCDSTACTIADKYFNVPAVGTMAHSWVQLFDTEFEAFKAWAETYPDNCSLLIDTYNVLKSGLPNAIKVFDEVLKPLGKRPTGIRIDSGDITYLTKKCRKILDEAGYSDCKIIISNSLDEHIIRDVINQGACIDSFGVGERLITAKSEPVFGGVYKLVAVEKEDVIIPKIKISENNEKITNPGFKKIYRLFDRDTNIAIADVLALSDEVIDDSKEYEIFDPIHTWKRKKVTNFYVKDLLVKIFDKGTLVYTSPSVLEIKEFAKVETNKLWPEILRFENPHTYYVDLSTKLWSLKQKLLLNQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCW7</accession>
    <name>A0A174JCW7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein STY0526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaN</name>
        <name evidence="2" type="ORF">ERS852471_02701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267389.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96461">
        <property type="protein sequence ID" value="CUO96461"/>
        <property type="gene ID" value="ERS852471_02701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047758at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007401">
        <property type="entry name" value="DUF454"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35813">
        <property type="entry name" value="PTHR35813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04304">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016789">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="15076" checksum="18F0B86151021D67" modified="2016-09-07" version="1">MNKIKKYIYITVGLIAFALGAIGVALPILPTTPFLLLASFCFARGSEKFNIWFTNTKVYKKHLESFVNERAMTLKQKVCLLAFADFMLAFPMILIDNLHLRIFLVCLILFKLYYFTFRIKTIKPQVEKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JEZ0</accession>
    <name>A0A174JEZ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267403.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96786">
        <property type="protein sequence ID" value="CUO96786"/>
        <property type="gene ID" value="ERS852471_02709"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029165at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO96786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16743" checksum="5F039C23548C05CB" modified="2016-09-07" version="1">MKKYFIFCIIAILIIVSVIKINIINTEILSPVGNFQDNFNKINEEFGEDFSEFIMDKSPMKIYLGEEGDNSATVKINKKEINLTKNNPFLKIFNPVIDFFKNSYKKIEEKFNEKTESKENVKEIENKGELENVVEDFINSLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JM32</accession>
    <name>A0A174JM32_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain, excisionase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98245">
        <property type="protein sequence ID" value="CUO98245"/>
        <property type="gene ID" value="ERS852471_02747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO98245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="57" mass="6818" checksum="A18536467BF71ECB" modified="2016-09-07" version="1">MEKLLFSVKETAEMLYVNKNKVYDLIKQGKIGYIDLGTRKIPKTEIDRFIRENTMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JYW0</accession>
    <name>A0A174JYW0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">carB</name>
        <name evidence="17" type="ORF">ERS852471_02878</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267717.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04942">
        <property type="protein sequence ID" value="CUP04942"/>
        <property type="gene ID" value="ERS852471_02878"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="674"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="932"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain" evidence="13">
        <location>
            <begin position="550"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="933"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="823"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP04942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1069" mass="118725" checksum="7A03B64A3E82679A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZ70</accession>
    <name>A0A174JZ70_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">uvrC</name>
        <name evidence="10" type="ORF">ERS852471_02823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267616.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02410">
        <property type="protein sequence ID" value="CUP02410"/>
        <property type="gene ID" value="ERS852471_02823"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="266"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP02410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="621" mass="72163" checksum="3C36327E08549310" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K039</accession>
    <name>A0A174K039_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267739.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05362">
        <property type="protein sequence ID" value="CUP05362"/>
        <property type="gene ID" value="ERS852471_02891"/>
    </dbReference>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="581"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="441"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP05362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120920" checksum="F24D35709FBF4E07" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K1K9</accession>
    <name>A0A174K1K9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation protein YkwD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ykwD_2</name>
        <name evidence="4" type="ORF">ERS852471_02908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05934">
        <property type="protein sequence ID" value="CUP05934"/>
        <property type="gene ID" value="ERS852471_02908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008025754" evidence="2">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="137"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP05934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="28422" checksum="E220450355E70F00" modified="2016-09-07" version="1">MKSKIIALVIAGATMLGTVSASAATRYYDSNNGGAYRHHCKHKYQRPCKPRQDEKPSTGDDNVVTPPTVGDDTTVTPPTSDDNTVVTPPAGEENTEVTPPTTGDDTTVTPPTNEGDAVTDDTNASDKFMAQVEQAIFNKVNEERVKAGVAPLSYNTTMEKYARIKSQDMGDNNYFSHTDLNGNYITDQMKADGVSYNSWGENIAYLGGDGTDPTVLANQFMTNWMNSSGHRKNILSTDFTSIGVGVYQIGNKVYATQEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K6V9</accession>
    <name>A0A174K6V9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
            <ecNumber evidence="6">3.6.3.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC_4</name>
        <name evidence="6" type="ORF">ERS852471_02915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.20" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP06176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267778.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06176">
        <property type="protein sequence ID" value="CUP06176"/>
        <property type="gene ID" value="ERS852471_02915"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP06176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="360" mass="40926" checksum="27B8CE954846F65B" modified="2016-09-07" version="1">MKVTLNNIGKKYESREDFTLRNINLEIEDKDFCVILGPSGCGKTTLLRMIAGLNSITEGDLLFGEKRVNKLASKDRDIAMVFQSYALYPHMTVYDNMAFSLSMRKERKNVINERVMEAAKLLQIENYLYSKPSDISGGQRQRVALGRAIVRKPSVFLMDEPLSNLDAKLREHMRIELVRIHKQLGTTSIYVTHDQVEAMTMATKIVLMNDGKIQQVGKPYEFYEKPQNMFVARFIGSPTINMIKGKMDGKKFISEDGLISVTPSEKDLKALANHIGKEVYLGIRSERFVSGETKDKFEGTIDVIEVLGKEKTLFVKLKSGKDMVITVPGHYQYEAGENHTFGFDLEALHFFDAETEERIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KAG6</accession>
    <name>A0A174KAG6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sinR_2</name>
        <name evidence="2" type="ORF">ERS852471_02973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267886.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09004">
        <property type="protein sequence ID" value="CUP09004"/>
        <property type="gene ID" value="ERS852471_02973"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="112" mass="12925" checksum="C1EBDAB1713B2241" modified="2016-09-07" version="1">MSLGKRLKKFRKCNGLSLKELSALTNLSISFLSDIEHDRSNPSINNLKILSSALNIPMYHLLEDSNSPSSDNSIDFSELVPILMEFEDWDNEDKIELFYYLKAKKTIRDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KAS6</accession>
    <name>A0A174KAS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araC_2</name>
        <name evidence="2" type="ORF">ERS852471_02939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07546">
        <property type="protein sequence ID" value="CUP07546"/>
        <property type="gene ID" value="ERS852471_02939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="236"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP07546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="38893" checksum="5CB28C506C9C5673" modified="2016-09-07" version="1">MISICKTTKEFQSRVLDKMTFSPYHKENCIIYKNESRPELGYFIKYSREDYYDFGVGDYTIPSDFSLSFDHEEELMRFGTVYTGETKFKIENNPVSSFSPSSFFVVEKTLKGNQVWSKGQHFHGAEITIHKKYFDEVIKPNFKNIIDFDYFITNYTYNYLPLEIASIIQHLKSLAEVERLTPIYLESKILESISLINDEINSSPNNAFTNQLNYGEIKIGKDRYITLTASDANAIKEAYDILTKEACNPPTIKSLSKRVFLNEQKLKAGFSAKYHMSISQYTNSIRMTMAENLLSTTELSIDEISKMIGYNYSGNFIKMFKKTHGKTPLDFRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KI58</accession>
    <name>A0A174KI58_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfite reductase, subunit C</fullName>
            <ecNumber evidence="8">1.8.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sir_3</name>
        <name evidence="8" type="ORF">ERS852471_02992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267931.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10176">
        <property type="protein sequence ID" value="CUP10176"/>
        <property type="gene ID" value="ERS852471_02992"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014261">
        <property type="entry name" value="Sulphite_reductase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02912">
        <property type="entry name" value="sulfite_red_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP10176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="323" mass="36628" checksum="66144348E02452AA" modified="2016-09-07" version="1">MIRDLDTGKVMKNAFRITKNKYITALRVRIPGGALSAETLKMVADIANKYGDGSVHMTTRQGFEILNIPMEYMEEVNKAIQPLIDKTKINQPIEGEGYPAAGTRNIAACIGNKVCPKAQYNTTDFARKIENIVYPNHLHVKIAFTGCPNDCIKSRIHDIGVIGMCLPEYNSYRCISCGACVKKCKQVSTNALKGVNYKVVRDHDKCIGCGECVLVCPNNAWTRNPKKYFRVCIMGRTGKKNPRIAQDFIKWADEDSVTKIIENTYKFTEEYIDPNAPMRKEHIGYIVDRMGFKLYKNYALEGVKLPDIAEVKDFVYWDGIHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KW68</accession>
    <name>A0A174KW68_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15141">
        <property type="protein sequence ID" value="CUP15141"/>
        <property type="gene ID" value="ERS852471_03094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP15141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="52" mass="5937" checksum="003C01A2A19F7F67" modified="2016-09-07" version="1">MSKQKRGKYIKTIPGWRGTCPVCGRKRVKLVWTKKGEDGKTLNICKLCSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZR6</accession>
    <name>A0A174KZR6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_3</name>
        <name evidence="2" type="ORF">ERS852471_03086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268113.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14789">
        <property type="protein sequence ID" value="CUP14789"/>
        <property type="gene ID" value="ERS852471_03086"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="247" mass="26252" checksum="787ECA7E79E39C57" modified="2016-09-07" version="1">MGKLTGKVALVTGASRGIGRAIALELSKQGASIAINFSKDVEGAESTLEEIISNGGYGKLYKKDISSAINCKELIQDVVSTFGKIDILINNAGISKVGLFMDFEDDSIEKLINTNLLGAMYLSKYAIANMISRGSGNIINISSIWGDVGASCEVVYSASKGGINLFTKALAKEVASFGIRVNAIAPGVINTDMNNFLDEDEKSDLINEIPQGRFGECDEIAKAVSFLCDDSCKYLTGQIIRIDGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L2Z3</accession>
    <name>A0A174L2Z3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wcaJ_6</name>
        <name evidence="4" type="ORF">ERS852471_03132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268186.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17056">
        <property type="protein sequence ID" value="CUP17056"/>
        <property type="gene ID" value="ERS852471_03132"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP17056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="22795" checksum="10A0416319C3E320" modified="2016-09-07" version="1">MKRVFDFLVSLISIIILSPVMLLIAVIIKCTSEGPIFFKQRRIGINNTEFQIYKFRTMRIDTPNVATHLLENPDQWITPIGKFMRKTSLDELPQLFNILKGDMSIVGPRPALYNQYDLKEMRTKLGVHEILPGLTGWAQVNGRDTIELWEKVKYDKYYLDNKRFLFDIKIIFLTVLGVLKSDGVQEGKLDNNKEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LAJ3</accession>
    <name>A0A174LAJ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bin3</name>
        <name evidence="2" type="ORF">ERS852471_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268236.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18559">
        <property type="protein sequence ID" value="CUP18559"/>
        <property type="gene ID" value="ERS852471_03160"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP18559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="215" mass="24879" checksum="04D48F23F5E6F4AD" modified="2016-09-07" version="1">MIFGYARISTTKDTQTTQRQLLTLKQYAKANSFTFDEILEERVSGTVNTENREEYSMLKNRLRKEDILILTDLDRLGRNADNVIMELKDLKSKGIRVIALDMPYMSDWNKVNDNSIYDMVIDIVITIKAHIAQQEREKIVSRINQGLSVAKAEGKTLGRPKAELPTDFVKEYIKFKEGQYGTMTSSRFAKMLGIGRSTLYKYINIYEINLERNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LDU4</accession>
    <name>A0A174LDU4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutN/carboxysome structural protein Ccml</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ccmL</name>
        <name evidence="1" type="ORF">ERS852471_03181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268271.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19760">
        <property type="protein sequence ID" value="CUP19760"/>
        <property type="gene ID" value="ERS852471_03181"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832681at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01614">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036677">
        <property type="entry name" value="EutN_CcmL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36539">
        <property type="entry name" value="PTHR36539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP19760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="80" mass="8387" checksum="BFF09E849F6A5C28" modified="2016-09-07" version="1">MFIGTVIGNVVSTRKEDNLMGYKLLIVKPADDYNNGKNIVAIDRVGAGINTEVIVTTGSSARLGLNKEVPADAAIVGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M0P4</accession>
    <name>A0A174M0P4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell envelope-related function transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrR_4</name>
        <name evidence="4" type="ORF">ERS852471_03310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000043">
        <property type="protein sequence ID" value="CUP27359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268485.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27359">
        <property type="protein sequence ID" value="CUP27359"/>
        <property type="gene ID" value="ERS852471_03310"/>
    </dbReference>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="83"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP27359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="311" mass="34767" checksum="D5A4013B0628C0E5" modified="2016-09-07" version="1">MKLSKGKKITLWVIGSLLTIIIATVATGYIYLNSLINKTVEVQVNQENIGITEEVEEELSKYSDTIINIALFGIDATDGGRGRSDSIMIATIDTHNKKLKLTSIMRDSYVSIEGYGNDKVNHAYAFGGPELAINTLNRNFNLNITEFASVNFSTLPKVIDLLGGVEIEIIDEEVSHVSGISDPGIYILTGEQALQYSRIRYASGGDYKRSERQRNILNSVFKKLLNMNVTQYPSLLNEILPMVETNLKSSDILDLGNEIIKMGIPSIEQERFPLDGYCQGQMIGGIYYLVFDKETAVSQLHNYIFEDTKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M1S8</accession>
    <name>A0A174M1S8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fieF_2</name>
        <name evidence="8" type="ORF">ERS852471_03330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000048">
        <property type="protein sequence ID" value="CUP28847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268516.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28847">
        <property type="protein sequence ID" value="CUP28847"/>
        <property type="gene ID" value="ERS852471_03330"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP28847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="32654" checksum="2E67FCF9A3C4035F" modified="2016-09-07" version="1">MNTRFDEANKVTMLSILWNVILTIIKIFAGILGRSSSMIADAMHSASDIISSIGVLIGNKISKTPNDKGHNYGHEKAETLVSFLLSILLIYVSLKIGFNGVKSLFHLDQVKIPTILPLIVSVISIAIKEYQYRITIKVAKKINSPSLKADAWHHRSDALSSIAAFIGIGGSMLGFKALDPIAAIVVALFVAKVGFDIFKDSANELMDCSISEEEESKIIEIAKETDGVIHLGELKSRKHGAMAYLDLTICVDKNLTVFEGHEIANNLEKCLLEKMNFIKGITVHVEPCINCNDTICLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEG7</accession>
    <name>A0A173XEG7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ureE_2</name>
        <name evidence="5" type="synonym">ureE</name>
        <name evidence="7" type="ORF">ERS852471_00017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UreE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118343.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49720">
        <property type="protein sequence ID" value="CUN49720"/>
        <property type="gene ID" value="ERS852471_00017"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1663151at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00571">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="17779" checksum="CD17CC81AB071BAF" modified="2016-09-07" version="1">MLFEKILGNLDELESTDGYHLEKIYIDSDDLVKRIIRVKSDHNHEHGISLDRGMKLRDGDILFNDGHNLVIVKVKSEDVLVIKPKDITEMAYIAHKLGNKHLPAHFEDDVMIVQYDYLVEDELRKDNINYSREDRRVKNAFTHVNFMEHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNH6</accession>
    <name>A0A173XNH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262799.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53441">
        <property type="protein sequence ID" value="CUN53441"/>
        <property type="gene ID" value="ERS852471_00084"/>
    </dbReference>
    <dbReference type="OrthoDB" id="913259at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="28138" checksum="037EC64FDD7DB3E9" modified="2016-09-07" version="1">MVKGKELNKSSSNLPSNFVIKAGDIDYIKPALFDGGYKGTFTAIKNACDEIWGDERGNLFVNSAYLDRILRTKSFVAKEILVNIPREDKLIFQGVTYVTLGEIMKIVTKRLQELPAGKTRAYLLLAEQFLINIRDNDKFLNKRTEMQLQLIEEFKTLKKKRIKSYKIENDELTGKILLKGAQFSHIRAKSVYPAYALNIDNGLIVNVDTHEIITARAIVNEESLLNLCVELGWKTDWYIVYKNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4F8</accession>
    <name>A0A173Y4F8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xerC</name>
        <name evidence="6" type="ORF">ERS852471_00199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59041">
        <property type="protein sequence ID" value="CUN59041"/>
        <property type="gene ID" value="ERS852471_00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="135"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="263"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN59041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="453" mass="52969" checksum="28127381D2157A20" modified="2016-09-07" version="1">MRGRTKTFKYKNYQYSDEVKKLLAISLSDYDKRNINEIRNNLKLSNMKRGYEYIIEDLYILVIKHNFTSSQLAKIYSLNVRSIQIWLKELGLNRTLKDAKKASLESNIFSDSDLIHNDQITQITKFKNKSAKNTSDLPQLVLDFLNYLETIKGKSKNTINGYKIDLQLFFRFMKVYKDNKIDDSLEFEEISISDIDENFINTIKLTDIYAFLSFVEKERQNSTYARARKVATLKSFYRFLFGKAKVIKENPTVELESPKINKRHPVYLTLEQSLHLLSSLDKGNINYYRDYCILTLFLNCGLRLSELCSIEINKIKNDTLTIVGKGNKERTIYLNDACIKSINDYLTKRDNSKISEENKKYLFLSIRNKPINKRTVELLVKKHITNAEILDNTYTPHKLRHTAATLMYKHGNVDIRSLQNILGHENISTTQIYTHIDDDKLRDAVRSNPLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y5M8</accession>
    <name>A0A173Y5M8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262998.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58486">
        <property type="protein sequence ID" value="CUN58486"/>
        <property type="gene ID" value="ERS852471_00189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="173"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="311" mass="37189" checksum="820DAACFB4CDF10B" modified="2016-09-07" version="1">MVSLVRLSSSNLDEFKKLYEENFQRETYDKDFFEYYYNQSFIPKIFLKKFVKLFMYNGEFIGYIWYEIPIDSQIKVFSLYVEDNYIDIITNDILKRFNEKYLVYESIENRNNNKLLSNLGFRKARPSIIMNLKLNEYNKTNEITNLKSTLKYDMKLLNLLNIYSNEKYDDILISFQKVDIKNDALLRCEIQNNVFKNIDRVPIEVEDIENDFKQDYYIKDLAIFMKINNVVVAYGQIIYIRKMYTVVNFGVVDIFRGKGLGKLLLDNLISKAREKNISELALGVDKDNVNAISLYKWIGFNNRYDIARWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y752</accession>
    <name>A0A173Y752_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">recA_1</name>
        <name evidence="6" type="synonym">recA</name>
        <name evidence="11" type="ORF">ERS852471_00206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263027.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59400">
        <property type="protein sequence ID" value="CUN59400"/>
        <property type="gene ID" value="ERS852471_00206"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="37399" checksum="BBC4A5E54946EA8A" modified="2016-09-07" version="1">MGNINAEKLKAIENAMSQIEKQYGKGAIMKLGEHNAMNVDAISTGCLDLDIALGIGGVPKGRIIEIYGPESSGKTTVALHIIAEAQKTGGVVGFIDAEHALDPSYAKNLGVDTENLIVSQPDTGEQGLEIAEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLHARLMSQALRKLAGTINKSKCVAIFINQLREKVGVMFGNPETTTGGRALKFYASVRMDVRRIDSIKQGDEIVGNRTRVKIMKNKVAPPFKQAEFDIMYNEGISRNGNIIDVGVKENIVQKSGAWFSYNDIRLGQGRENAKQYLKDNPHIALEIENKIRSKYNLPLMEEKKEKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YDS8</accession>
    <name>A0A173YDS8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeats (3 copies)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263081.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61155">
        <property type="protein sequence ID" value="CUN61155"/>
        <property type="gene ID" value="ERS852471_00236"/>
    </dbReference>
    <dbReference type="OrthoDB" id="867701at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="125" mass="14754" checksum="DDF1A5BE5DAA74B9" modified="2016-09-07" version="1">MKIFGCNDIISATRNNNLKLVEELIKSCNIDYKDRNHKSAIFYAVDNCNIEILDLLIDNGANLYIRDDRGLTIFHYIILNENNILIDYFINKKKIIFNIEKVKEEVKDIKVKDDRVFLNIIKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSX9</accession>
    <name>A0A173YSX9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pbuG_1</name>
        <name evidence="8" type="ORF">ERS852471_00303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263227.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66553">
        <property type="protein sequence ID" value="CUN66553"/>
        <property type="gene ID" value="ERS852471_00303"/>
    </dbReference>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN66553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="461" mass="48687" checksum="EC8BD91E0AD0C5B6" modified="2016-09-07" version="1">MGELSTKKLSTKEKLLPILTNKNVDIKKEMLAGLTTFLTMAYIIAVNPNILSATGMPAGALVTATCLAAALACIMMGLFANLPFALASGMGLNAYFAYSVVLGMGISWEVALTAVFIEGIIFILLSIFKVREAVVNAIPKNMKLAVTGGIGLFIAFIGLVNSGLVVSDEATMVALGEFTPAVIITLIGLVIITVLNKKGVRGSILWGILISSLIGWGYALINTEAAAALGIYLPSGVFKFEGIGEIAGKIDLAHAFHPDNLKMFITVVCTFLFVDFFDTVGTLVGVCSKAKMLDKDGNVPNAGRALLVDAIGTTAGACLGVSTVTTYVESATGVAEGGKTGYTSITVGILFLIAMFFSPIIVAIPSCATAPALIYVGYLMLEAVKEIEFENITEGVPAFLTIAAMPLTYSIGDGLTLGIISYVVINLIYNIFFAKSKEKKTKISWVMYLLLVVFILKIAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YU30</accession>
    <name>A0A173YU30_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 16" type="primary">gpsA</name>
        <name evidence="16" type="ORF">ERS852471_00299</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263219.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66338">
        <property type="protein sequence ID" value="CUN66338"/>
        <property type="gene ID" value="ERS852471_00299"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="177"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN66338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="35572" checksum="C58B8D820C8FB03F" modified="2016-09-07" version="1">MSKVTFVGGGSFGTSLAILLGNKGNDVSIYDRDISVVNDININRKNDRYIKGLEVPKNVTAYNDVDKALEGAEYVVLALPSQIIRIGAKTLKGKISSDIPVICIAKGIEEGTNKTLVEVINDEIDNPVVVLSGPSHAEEVAFNIPTTVVTSSKNMKVAEEVQDLFMTKEFRVYTNSDLVGVEIGGAVKNIIALAAGVCDGLGYGDNTKAALMTRGMAEIVRIGTKLGGNIETFLGLTGMGDLIVTCTSMHSRNRKAGILIGKGMSKDDAVKEVGMVVEGITACNAFYKLKEQLDVEMPITDGLYRVLFENRKAKDVVDELLKRDKKSEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z930</accession>
    <name>A0A173Z930_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartate/ornithine carbamoyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygeW</name>
        <name evidence="5" type="ORF">ERS852471_00403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263403.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72179">
        <property type="protein sequence ID" value="CUN72179"/>
        <property type="gene ID" value="ERS852471_00403"/>
    </dbReference>
    <dbReference type="OrthoDB" id="988597at2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
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        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
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        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017702">
        <property type="entry name" value="Carbamoyltransferase_YgeW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03316">
        <property type="entry name" value="ygeW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="187"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN72179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="44526" checksum="3AECBCCD51EEC698" modified="2016-09-07" version="1">MALMDKYIEKLNGLDLKEMYNNDFFLTWEKSDDEIQGVFTIAEALRELRKNNISSKIFDSGLGISLFRDNSTRTRFSFASACNLLGLEVQDLDEGKSQIAHGETVRETANMISFMADVIGIRDDMYIGKGNTYMRNVSEAVQEGYRNGVLEQRPTLVNLQCDIDHPTQAMADALHLINEFGGVENLKGKKVAMTWAYSPSYGKPLSVPQGIIGLLTRFGMDVVLAHPEGYEVMGDVEEVARRNAEKSGGSFTKTNSMEEAFKDADIVYPKSWAPFVAMEKRTDLYGKGDLEGIKELEKELLAHNANHKDWECTEEMMKLTKDGSALYLHCLPADITGVSCEAGEVAASVFDRYRDPLYKEASFKPYIIAAMIFLSKVKNPQEILAKLENDNKARKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD97</accession>
    <name>A0A173ZD97_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein</fullName>
            <ecNumber evidence="2">1.3.7.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcrA</name>
        <name evidence="2" type="ORF">ERS852471_00448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.7.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263483.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74362">
        <property type="protein sequence ID" value="CUN74362"/>
        <property type="gene ID" value="ERS852471_00448"/>
    </dbReference>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="760" mass="83081" checksum="1D064F34BB5EBC91" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4D7</accession>
    <name>A0A174A4D7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_2</name>
        <name evidence="2" type="ORF">ERS852471_00537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263659.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82396">
        <property type="protein sequence ID" value="CUN82396"/>
        <property type="gene ID" value="ERS852471_00537"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="28441" checksum="ADF3BA0CC20C59EA" modified="2016-09-07" version="1">MNFKDKVCVITGGANGIGRCIVEEFIKAGTKVAIIDTDKISGNNLIKKFGEENLFFYYGDITEENTLNDFVNKTIEKFKNIDYLINNACISRKGILSDCSFNDFNYVLKLGVTAPYMLSKLFLNYFNPKASIVNISSTRAYMSQADTESYTAAKGGISALTHGLSISLAGKVRVNSISPGWIDTGAYQHSENYKPQYSIGDTSQHPSGRVGEPLDIANMVLFLCSDKAGFITGENITIDGGMTKQMIYHDDCGWNYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKC9</accession>
    <name>A0A174AKC9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263830.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88884">
        <property type="protein sequence ID" value="CUN88884"/>
        <property type="gene ID" value="ERS852471_00628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017730" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="107" mass="12299" checksum="9A0D9607B49132AB" modified="2016-09-07" version="1">MLKKLLIALIIVLSMFSTKVYCSEDLIPAISNTYTEGFYRFDNTKTVNINVTLTTDTLTKMMIFDENLGLQYFSILPVKEKFTLRNIEPNRIICIIGEGEVALTFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALK5</accession>
    <name>A0A174ALK5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvgN</name>
        <name evidence="5" type="ORF">ERS852471_00643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263852.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89641">
        <property type="protein sequence ID" value="CUN89641"/>
        <property type="gene ID" value="ERS852471_00643"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="17"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN89641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="31341" checksum="25805B4EE805A10E" modified="2016-09-07" version="1">MESMVRKLSNGVDIPSIGFGTYKLGEEQEVIDKVKLALNLGYRQIDTASFYGNEEGVGKGIAESGIDRKDIFLVTKLWNDDHGYEETINAFNKSIKKLGVDYLDLYLIHWPNKLNSETWRAFEDLYKEGKVRAIGVCNFKIGHLEELKKTAKIMPMVNQIEIHPCKTQKETIEYCNENNIQVVAWGPIMRGKILSLPLMLELSEKYNKSIAQITLRWHIQNGVIPIPKSSNEERIKANIDIFDFDISSEDIKKIDELNVNEDISGVPANTTYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMM0</accession>
    <name>A0A174AMM0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Antibiotic ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydgH_1</name>
        <name evidence="8" type="ORF">ERS852471_00625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263824.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88696">
        <property type="protein sequence ID" value="CUN88696"/>
        <property type="gene ID" value="ERS852471_00625"/>
    </dbReference>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="548"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN88696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="693" mass="76147" checksum="A74260B3E68D922B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASJ0</accession>
    <name>A0A174ASJ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263898.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91612">
        <property type="protein sequence ID" value="CUN91612"/>
        <property type="gene ID" value="ERS852471_00669"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN91612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="317" mass="36627" checksum="C781E025CF1EEB00" modified="2016-09-07" version="1">MRENFKFKDSDGVELNVYKWIPDGEIRGIVQISHGMTENVLRYDEFANYLNNEGFIVYGHDHRGHGLTAKSKEELGYIADNEGFDWLVRDLYELMMMIKEENKGLPIYLFGHSMGSFVSQRFIELHGNEIDGVILSGSNGEPTKLTPLGILLSNIEIKLFGRKHTSKMMDKLSFGDFNRKFRPNRTPYDWLCSVEEEVDKYIDNEYCGFVCSASFYYDLLRGLKAIHKKENFNSIPKDLPIYIIAGDMDPVGFFGKGIVNLYNKLQSIGIKDVNYKLYKDKRHEILNEDNKLEVMNDVSAWLLRKLEGFSTSECRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AU64</accession>
    <name>A0A174AU64_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphonate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phnE_2</name>
        <name evidence="7" type="ORF">ERS852471_00659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263878.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91008">
        <property type="protein sequence ID" value="CUN91008"/>
        <property type="gene ID" value="ERS852471_00659"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1209768at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN91008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="30071" checksum="69C42CBDEC66F396" modified="2016-09-07" version="1">MLEKIKSIFKPKKIVLNNGKEMQPPTPIAPFVIIGLVIALIIAGDVTGFKFETIVKRGNEFFVILKDMFPPDFSYIKSVIPPLVETVKISVLGSMIGSFIAIPFAMMCSVNINKSKIVLNLIRVIMSITRTLPTLIIALISTYIFGLGTFAGTVAISIFTFGIVTKMLYEKIETVDMGPFEAMEAVGATRVKAFVGSIMPQIMPSYLSICLYSLEINVRAAAILGYVGAGGIGLILNEKIGWREYDKVGMILVMLFITVVIIENGSKYIRERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVF5</accession>
    <name>A0A174AVF5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfkN_2</name>
        <name evidence="5" type="ORF">ERS852471_00667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263894.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91500">
        <property type="protein sequence ID" value="CUN91500"/>
        <property type="gene ID" value="ERS852471_00667"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="313"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN91500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="503" mass="57504" checksum="8C5BEDB002C7AA7B" modified="2016-09-07" version="1">MKVAIYQTSDLHGYVYPTNYVKDMPLGILKIGSYILKDEKNYDASLKIDCGDLIQGSALAHYLSKEKIERNPLIQGLEFIGYNAYVIGNHEFNYGKDYLINSYKEVEDKIINSNIEGLSLETKPYKIFDFNGFKIGCIGFTTSFIPNWEHEKNIDGLNFLDPVETYGIYEDELKEKTDFIVVCYHGGFEKSLDGNNTPTEKLTKENQASELLEKYDSIDMVLSGHQHRSFITKINGIVCAQPLHNGQNFTKIVLDTESKEASYELIDVSKLNDEINQDMEKIFNNVQAELQDYLNNEIGEFDKDILMDDIFIARLKGHPFINFLHQVQLDVSGADFSALSLFDSAIGFKKNVSIRDVLINYPYPNTLMVLKINGHKLKEAIEKAATYFVVEDGEVKINNGFLVPKVQNYNYDTFGGLTYEIDLSREFGDRVVSMKKDNEEIDLDKDYTVVLNNYRATNTSIYPAYENAKVVKEINVDISEIIINYFQGNKKIKVIDESNYVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B647</accession>
    <name>A0A174B647_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="5 9">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moeA</name>
        <name evidence="11" type="ORF">ERS852471_00719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264002.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96297">
        <property type="protein sequence ID" value="CUN96297"/>
        <property type="gene ID" value="ERS852471_00719"/>
    </dbReference>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8 9" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="10">
        <location>
            <begin position="178"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN96297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="401" mass="43740" checksum="911F102E1A7FCA37" modified="2016-09-07" version="1">MKSFISLEEAIEILSENVRFIGIEEVSLLSGIGRILSEDIFSKIDNPPFNKSAMDGYAVISIDTEEGKKSLKVIDQVFAGDVCKSEVKQGTAIKIMTGAPIPIGANAVIKQEDVTFKDGFIEVNKVLKAEENICLKGEDIKEGTLLVKKGKKLDYADIGILASSGIRTVNVYKKPRVAFISTGDEVLDLDEALIGGKIYNSNKYTILGRLAELGYEVTYVDHENDSFIGIGNKIKEASRVADFIITTGGASVGEKDLIKEVIDYINGEKLFWKINIKPGSAMLCSKYDEKIIVSLSGNPTAALTTFELIAKTTLEKLSGKEHIEISREKAILTNEFKKKSPNRRFLRGTVTSDVNGQKVEITQVKSGNGILSSTLNSNCLIELEAGNEGVNKGDIVTIIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAQ1</accession>
    <name>A0A174BAQ1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlD</name>
        <name evidence="4" type="ORF">ERS852471_00741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264044.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97513">
        <property type="protein sequence ID" value="CUN97513"/>
        <property type="gene ID" value="ERS852471_00741"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN97513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="29968" checksum="432FCA9F107169DB" modified="2016-09-07" version="1">MKKVLVTGSNGFLASRFSEYYKDKYDILALSHKDLDITNEKKVYDLFKNNNFDIVFHSAAISDTGRCQNEPEFANKINFDGTVNIAKGCALKDSKLIFASSDQLYAGNEIKNIFDKYYNLRLTWMFSYAERNKRVNINIITNILNETLKGEKISLATNEYRGISYVYEVIENVEKLLEVSYGDYNFGSENDISTYDIGCRVLENLGLQNRIEDILIKDTERFKDKKRDLRISNKKLRDNGIYFESTEEAISRCIREFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C321</accession>
    <name>A0A174C321_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264326.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06290">
        <property type="protein sequence ID" value="CUO06290"/>
        <property type="gene ID" value="ERS852471_00881"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923113at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="12727" checksum="87F7C04F3D2D3314" modified="2016-09-07" version="1">MKKIYLSEQLEKLKEYPVEVINNVLEVINVLDENYGANRHIDNDLGGYVLIAENIVDIKILKQDKLQGLIPEYTDIIECSEGINYTCTLYLISNDYAILVVTTEELSKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3G4</accession>
    <name>A0A174C3G4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264324.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06256">
        <property type="protein sequence ID" value="CUO06256"/>
        <property type="gene ID" value="ERS852471_00880"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026766at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="11834" checksum="40EA187983BC0E35" modified="2016-09-07" version="1">MGRKKLNKVLKSTKYCDLLSQASLNDDQYTYCIERIYVKAKKMEEIRFTLYKETLNSGNRYIPRSLDVTEIELIKLIRSSLEGNVFSSGFIKMLKEEINKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CF52</accession>
    <name>A0A174CF52_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdhB_1</name>
        <name evidence="11" type="ORF">ERS852471_00997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12191">
        <property type="protein sequence ID" value="CUO12191"/>
        <property type="gene ID" value="ERS852471_00997"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1720141at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="226" mass="24376" checksum="7BA2C462045D6516" modified="2016-09-07" version="1">MKTVGVFDILGPIMVGPSSSHTAGAARLGKVARSIADADIKEVTFLLHGSFGKTYKGHGTDRALVAGILGMEPSDLRLRDSLNIAREQGIDISFKETDLGESHPNTVKFLITGKEGKQYEMVGSSIGGGSIEVSEVNGEKVEFTGAYPTIIISHVDVPGVVSNVTKLLYDHAINIAFMKVFRSQKGKEATMVFDVDNEVTDEIIEEIKIMESINKVIRINPIKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZA0</accession>
    <name>A0A174CZA0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator FruR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fruR</name>
        <name evidence="5" type="ORF">ERS852471_01099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264619.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18831">
        <property type="protein sequence ID" value="CUO18831"/>
        <property type="gene ID" value="ERS852471_01099"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO18831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="27824" checksum="C3B072873046A6C9" modified="2016-09-07" version="1">MLTQERHALILEKLEKESVVYLSDLINLLDASESTIRRDLNYLDKAGLLKKVHGGATSLNSKLINTTEFEVEVRQGINKEDKIAIAKYAASLIKNDDLIYIDSGTTTELMIDFIEAKGATFVTNGIGHAKKLIHKNLTTYILGGELKLTTEAIIGIEAINSLRKYNFTKGFFGANGIDIERGFTTPDIREAMVKEEALKKSKLSFVLADNSKFNEVSSITFGEISNTSIITTKLEDIRFKKVTKIVEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1W0</accession>
    <name>A0A174D1W0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264630.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19433">
        <property type="protein sequence ID" value="CUO19433"/>
        <property type="gene ID" value="ERS852471_01110"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2128705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024300">
        <property type="entry name" value="DUF3794"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12673">
        <property type="entry name" value="DUF3794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3794" evidence="1">
        <location>
            <begin position="270"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="396" mass="45263" checksum="3E6638BF23257627" modified="2016-09-07" version="1">MSESSLKEIKFKIYDVNSFKYPKYSIINGIKITNLKIFSKIISKNNILVYGNYDIVINYKNIIYSHYTSKQLIKYKKVFFHKPLYCNISKLGLVNSLNTKINLLSRPLPIYSLKKFPCPLFLDVNLCEVTLFLSISISTYNDNHLFNYNDINSNIANDYSSANNNNNNNNNNINLNSDNSSSNYDKCLNITSSPSNNHNYLDNNIFVPKGNPLIINNNAEDHPSSSINLYHNISKLPMRKLIETDVILGKGHSELFLEKIIDLSDPIKPIWKITKVIAKADITKIDISGEKAFANGFVYIDINYKTYLSLDMDAINGTIQYIHLSIPFSLCIDLVTEYNDKIKDSDDCKVSSIYVSEVHNLSRPTTLDNETIYNEFKGQFIVQVTVLVTRTVNIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7S9</accession>
    <name>A0A174D7S9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">thiE</name>
        <name evidence="12" type="ORF">ERS852471_01160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21792">
        <property type="protein sequence ID" value="CUO21792"/>
        <property type="gene ID" value="ERS852471_01160"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO21792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="22719" checksum="47848EC41E78019B" modified="2016-09-07" version="1">MKELKLYLVTDSDILRDRDFYKSIEAALKGGVTMLQLREKNASGKEFLKKAVRLRELTRKYDVKFIINDRVDIAMLCDADGVHVGQSDIPADKVRQLLGPNKIIGVSARTVEEARTAKENGADYLGVGAMFTTTTKLDAKAISIEKLMEIKENVNLPIVAIGGLNLNNIEMLKQCNIDGYAVVSAILKAEDINTECEKWIDAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8V6</accession>
    <name>A0A174D8V6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase regulating citrate/malate metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20719">
        <property type="protein sequence ID" value="CUO20719"/>
        <property type="gene ID" value="ERS852471_01138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="344"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO20719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="453" mass="52277" checksum="3D7DDDF28742DBE1" modified="2016-09-07" version="1">MIGFKGEIAMTFNSNYASDLFKLLIYSIVMNWFLGRKLEFKKKISKINIIIGTLIVIILTTVLMSVWLEKYNTIMVTELITLVPSIIYLFIYKKGSIWEKLYLVSTYIILIATMNILFFYIYLTVKGIPTTLAINIDFVKKYIVTAKIIIYLISLIIFSRIFKYIKLKDNSVLPVITISNIIMASADNILMNRFIYVGKSIGNESAFVAIAILISHFLLIRILNLSYEKSKKLIITECNLNKLEADSKYNKEIRTIYNEMTQWKHDWQNHINVAMYMLKEKRYEEAGKYLGEISNSINYDRKYKSFITTNNNVLNAIINSKIIVAVDKNIDVKTSVNITEPIHIDDIDLCGLLGNLLDNAIEACERTKSNRFINIKIITVKKNLIILIKNSMSGNIELIDNEYFSSKRKGLLGRGIAQINKIVDEYNGVVTRKHDNYIFETKIVMENTEKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFB1</accession>
    <name>A0A174DFB1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mate efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_5</name>
        <name evidence="2" type="ORF">ERS852471_01184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264697.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22858">
        <property type="protein sequence ID" value="CUO22858"/>
        <property type="gene ID" value="ERS852471_01184"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="439" mass="48066" checksum="11DA938F49DD99DA" modified="2016-09-07" version="1">MKKVDLTKGKVLTVLTALAVPIMGSSLLQFTYNLVDMLWVGGLGSDAVASVGSSSFFIGLGYSINSLVVIGAGIKISHAIGGKDNNNVKEYINTGIAINFFIAIVYALILIFLGKNFIGFLNLGNPIVERDSYYYLAINGPILYFSFFNFLYSRIFGSFGNNSDALKINAIGIAVNIILDPIFIYIFKFGVIGAALATLIANVIMYVLYKVKSKGLLKYDRSLNVNYEKVKEVAKLGFPMAFQRVLFTLVNIVLARIIAIFGTNAIAAQKIGLQIESITYMVIGGLNGAISSFTGQNFGAKKFKRINDGYNTALAIGISYSILMSLIFIFFKEPIIKLFIRDVDTSLIAYGYLQAVAYSQAFSTIEMVSNGLFTGLGKPKIPATISIIFTVLRIPMALVLMKYYGINGIWWSIAISSVLKGVAAYLIYKLKVSKEYKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DUM2</accession>
    <name>A0A174DUM2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264793.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27560">
        <property type="protein sequence ID" value="CUO27560"/>
        <property type="gene ID" value="ERS852471_01254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO27560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="231" mass="26268" checksum="EBF77B869BC682E6" modified="2016-09-07" version="1">MNKLVNFIKQVNTLSSTLENYYYIYTSNNINQSDIKKLKELKCAIKTNITEDILTAYNEGVSRDDLYYIVNAQSDDEIRSIFGKCRYVVSDFYQLEKINSISKELIKKGFLESIAISFSLDNNSTFCKENLSKLSLALKNADAIAVRGVFFICNATTDNEYINYMKSAYETAKEIASTLPCKITFINFGSCIDSLSKASLKKSNSDLQYIQNTNLVSYLNTTSFYSRFLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E339</accession>
    <name>A0A174E339_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dapB_1</name>
        <name evidence="9" type="synonym">dapB</name>
        <name evidence="12" type="ORF">ERS852471_01324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264917.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30695">
        <property type="protein sequence ID" value="CUO30695"/>
        <property type="gene ID" value="ERS852471_01324"/>
    </dbReference>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="116"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="27543" checksum="AF8E1FB7BD0952F8" modified="2016-09-07" version="1">MLKVILNGCNGAMGRAVTKVVSESLDVEIVAGIDKNIEMHQNSYEVFNNIFDYKGKADVIIDFSHPSCLDDILSYGKKNNTPMVIATTGLSSEDYKKIESVAKNVPIFKAANMSLGVNLLIDLVKKAALALQENFDIEIIEKHHNKKVDAPSGTALMIADAINEELDNSMEYKYGREGKKAKREEKEIGIHAVRGGTIPGEHTVIFAGLDEILEVKHTALSKNVFASGAVKAAKFIVNKENGLYKMEDLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E695</accession>
    <name>A0A174E695_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase 3</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA topoisomerase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topB2</name>
        <name evidence="6" type="synonym">topB</name>
        <name evidence="8" type="ORF">ERS852471_01356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264977.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31976">
        <property type="protein sequence ID" value="CUO31976"/>
        <property type="gene ID" value="ERS852471_01356"/>
    </dbReference>
    <dbReference type="OrthoDB" id="100725at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00953">
        <property type="entry name" value="Topoisom_3_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="6">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO31976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="729" mass="83049" checksum="4576A4941F687367" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAG1</accession>
    <name>A0A174EAG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265039.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34633">
        <property type="protein sequence ID" value="CUO34633"/>
        <property type="gene ID" value="ERS852471_01394"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014691at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="93" mass="10956" checksum="34303F5B5E2D9EBF" modified="2016-09-07" version="1">MRKKITLRSIVIIILFVVFGFNVVKQTMAIKRINNDIAKKSEQLNEKKEENRKLQAELERVQSNYDYLEKLARERLGLIKEGEQIILPSEPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBA2</accession>
    <name>A0A174EBA2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoVT</name>
        <name evidence="3" type="ORF">ERS852471_01401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265051.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34933">
        <property type="protein sequence ID" value="CUO34933"/>
        <property type="gene ID" value="ERS852471_01401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014213">
        <property type="entry name" value="SpoVT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026579">
        <property type="entry name" value="Spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02851">
        <property type="entry name" value="spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="182" mass="20312" checksum="12526FE1C2038916" modified="2016-09-07" version="1">MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFTDREGGVILKKYSPIGELTDFSKEYAESLQGSIGHIVLIADKDTFISASGAPKKDYLERKISSELENVMNDRKAVIITEQNKTIPLHNDEDEKLYSNQVVAPIIAEGDAIGAVLIISKEENEKFTDLELKLAETAAAFLGKQMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBS4</accession>
    <name>A0A174EBS4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purC</name>
        <name evidence="10" type="ORF">ERS852471_01377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265019.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34046">
        <property type="protein sequence ID" value="CUO34046"/>
        <property type="gene ID" value="ERS852471_01377"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345271at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="236" mass="27207" checksum="278056D2E1BD7471" modified="2016-09-07" version="1">MVNKYEKLYEGKAKQIFRTDNEEHVIVHYKDDATAFNGEKKAQIQNKGVLNNQITSMIFEMLNKNGIKTHFIEKLNDRDQLCKRVEIVPLEVIVRNVAAGSMAKRLGLEEGFKLKTTVFELSYKDDSLGDPLINDYHAVGIGATTFEELNNIYEMTAKINDLLKEFFKKQNIDLIDFKIEFGRLPNGEVVLADEISPDTCRFWDSTTGEKLDKDRFRRDMGNVEEAYVEILKRIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EE02</accession>
    <name>A0A174EE02_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proton-coupled thiamine transporter YuaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiT_2</name>
        <name evidence="2" type="ORF">ERS852471_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265095.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36112">
        <property type="protein sequence ID" value="CUO36112"/>
        <property type="gene ID" value="ERS852471_01425"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1865311at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012651">
        <property type="entry name" value="Thia_Transptr_ThiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09515">
        <property type="entry name" value="Thia_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02357">
        <property type="entry name" value="ECF_ThiT_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="217" mass="23442" checksum="266D6150222E06E0" modified="2016-09-07" version="1">MTNFLATLSENFKTLFSSPLTLLTLLACGILLIAFIKFKSIKFNAQLMARIGLALALAIILDMIKLYTFPNGGGSVSLGSMIPIFIISYVYGPSVGIFTGFLFGLLKLMINPYILSPIQVLFDYPLPFMAVGIAGFFRDKKLIGATVGMFLRFICHFISGVVFFGEYAPAGMSPAIYSLAVNGPAVGVELLICLVILGLLPLNQILKTLNPSSNINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFA1</accession>
    <name>A0A174EFA1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yugI</name>
        <name evidence="3" type="ORF">ERS852471_01393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265037.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34590">
        <property type="protein sequence ID" value="CUO34590"/>
        <property type="gene ID" value="ERS852471_01393"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="15081" checksum="C86E064CC29A6C34" modified="2016-09-07" version="1">MTLAAGKILEGTVVNITNFGAFVEIEGKTGLVHISEVADSFVKDIREHLNEQDKVKVKVISIDDNGKISLSIKQANVKKKSVKPAEFEWGTEKKKTNTANFEDIMSRFLKDSEERQQDYKKNQEFKGRSKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENM7</accession>
    <name>A0A174ENM7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265204.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38887">
        <property type="protein sequence ID" value="CUO38887"/>
        <property type="gene ID" value="ERS852471_01486"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269079at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="PTHR38149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO38887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="564" mass="62981" checksum="56C9289482C72EF8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUZ3</accession>
    <name>A0A174EUZ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">16S ribosomal RNA methyltransferase KsgA/Dim1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265256.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41291">
        <property type="protein sequence ID" value="CUO41291"/>
        <property type="gene ID" value="ERS852471_01512"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1220972at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="29616" checksum="76D94E2C1961A71A" modified="2016-09-07" version="1">MKPFDRDYVLSKIKEYNRKIRPRKIGDFEIKRIDGLQGIVQGYLYERKDRIRLKIAELVHDYDHVWMRLTPLEIEGSYFAIERAKGKVGIVGLGLGYVAQEMAKKEEVDEVIVYEVSKDVIDLYNCNFKDNPKITIINKDAFEAESEEFDFFYADIYEYKITSQIVKDYEAFNTLHKIEEYSFFGMEHFLLSCSYEEIVWVYIPENWMEMAREAYDALEQSELLDYYKPLDKEIVSAVLQKFKIVLDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXT0</accession>
    <name>A0A174EXT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A core-O-antigen ligase and related enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265296.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42271">
        <property type="protein sequence ID" value="CUO42271"/>
        <property type="gene ID" value="ERS852471_01533"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1280775at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO42271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="489" mass="55225" checksum="95F52E201EB20C6A" modified="2016-09-07" version="1">MKILTKDSNSIIDNPRIAKLLIVLFLSSLFLIPFDDLPYITFLGGLGKRAAFYPFFAIIPIIAYISLIKRRIYISLTLEKYILIIFYIWICISTVVNFNNIMSSSYKGTSGISKSLIQIITLTFVITSSYCIELIISTKKVSLYTIRKFISLSLIPVTFVSLLEIFNMINLYDLSHILEIITYTINTALRGFVYGGRSRGVSAEASYLGMYCAFIFPWIISYLYTEKTKFKKVFFSFISLLILLIVIATKSRTATILILFELVSLFGLVLLFYSNIRIKFITTLIIILFSLCLFTFPKLLGSIKTSLSNRDNPIITENSQNIASSEYDVGSIVSSVTDSNNLSNIARSTMQNAAFKIGIDNPIFGVGLGQFAFNFSPYIQEDSLRSNEVKIWLDNSISTWPPVHSLYHRLFAESGLVGLLLYVSFVFIVCLKLLIKLIKSKKDILGMLLLISYSSIVIGSLTVDTLLIGQFWIMTPILILYTSDKLMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1M7</accession>
    <name>A0A174F1M7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB_2</name>
        <name evidence="7" type="ORF">ERS852471_01558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265348.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43601">
        <property type="protein sequence ID" value="CUO43601"/>
        <property type="gene ID" value="ERS852471_01558"/>
    </dbReference>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="5"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="350" mass="40424" checksum="B52F91631164CD41" modified="2016-09-07" version="1">MKTYLVTGGAGFIGSNFVLYMLNKYNDIRIINLDKLTYAGNLENLKSIEGNERHIFVQGDICDSKLVAELFEKYEIDYVAHFAAESHVDRSIREPEVFAKTNVMGTVNLLNCAKNAWENEDGTWKEGVKFLHVSTDEVYGSLGETGYFMETTPLDPHSPYSSSKAGSDLMVKAYYDTYKMPMNITRCSNNYGPFQFPEKLIPLLINNCLQHKDLPVYGDGMNIRDWLFVEDHAKAIDMVINNGRVGEVYNVGGHNERTNITIVKTVISYLNENVDKEVTENLIKYVEDRKGHDRRYGIDPTKIKEELGWYPETTFEVGIKKTIQWYLDNQEWMNNITSRDYMNYYNQIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F707</accession>
    <name>A0A174F707_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265443.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45884">
        <property type="protein sequence ID" value="CUO45884"/>
        <property type="gene ID" value="ERS852471_01608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="15109" checksum="CC543FA7492FD077" modified="2016-09-07" version="1">MQRARELKYEEIDGKPYFTADKAKVDEVAKNIFNVDIYTDKLRDDLYEAIYVDSKLIAFKDNKYVISTASGRMPGFVNLVDSITKSKEGSYKIDFTIYDIIDSGYIGKQGELIRNRDLTNCIISGNGVAEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FF74</accession>
    <name>A0A174FF74_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)</fullName>
            <ecNumber evidence="2">3.6.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265495.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48187">
        <property type="protein sequence ID" value="CUO48187"/>
        <property type="gene ID" value="ERS852471_01636"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO48187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="191" mass="21953" checksum="B0E145BCC3C40CC5" modified="2016-09-07" version="1">MISIYEMNKYLKENLIENRYNHTVGVVNTAIELAEIHGEDKFKAEIAALSHDIAKNMKVTDLKKLIDEEGISLTIDEERNIELWHAIVAPILGKKVFKIEDDEILSAMRWHTTGKENMSNLDKIIYLADLIEPSRKFNGLDELRKVAREDLDLAMIKALTHTIKFLLDRGVAIDGNTFKARNYLLYNNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FG88</accession>
    <name>A0A174FG88_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ComE operon protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comEA</name>
        <name evidence="3" type="ORF">ERS852471_01632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265487.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47958">
        <property type="protein sequence ID" value="CUO47958"/>
        <property type="gene ID" value="ERS852471_01632"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO47958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="23819" checksum="98BD599DBE7EE4C2" modified="2016-09-07" version="1">MDKFKDKRVIAIIIVLTILFISSIILYGKNNNKVFTDKYMQNIFVDSEEQISNNSINNMETLVTNEEKLDVPMIFVEIKGEVLSPDVYELQEGSIVKDLIEKAGGLTGEANISNINRAKKLQNHELVIISNINDENANTVFNEVILESNGLININLADINELKKITGIGEVKAQSIIEYREKNGGFKSVDEIKNVDGIGEKTFEKIKEKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLB1</accession>
    <name>A0A174FLB1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265538.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49270">
        <property type="protein sequence ID" value="CUO49270"/>
        <property type="gene ID" value="ERS852471_01658"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721194at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="27478" checksum="4529E497EBCE7916" modified="2016-09-07" version="1">MKYTKYNYKRRRNNGVWKFIASLLVGIIASCMIGLGVAWIVWKVLPINDSAQVGAEITDGIEVSTEGNGQQQEGETIVSEGENTSEYYFLQCGYFSKKDNADQTYAKIASEGRAFIAEESDKYRVLTGIYTSENVDSAIQELGSKGVESVKITFSLNENDPIEAQVSAICDGYLKILTTTFDDGVDHVNTEEFKSWIDTLDNISSGENIEVLQSLKDYIKGLPEELTKENVSSEIDYLYEVLLSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSC5</accession>
    <name>A0A174FSC5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanophycinase</fullName>
            <ecNumber evidence="4">3.4.15.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cphB</name>
        <name evidence="9" type="ORF">ERS852471_01739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate</text>
            <dbReference type="Rhea" id="RHEA:12845"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137991"/>
            <dbReference type="EC" id="3.4.15.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.6" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265677.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53154">
        <property type="protein sequence ID" value="CUO53154"/>
        <property type="gene ID" value="ERS852471_01739"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011811">
        <property type="entry name" value="Peptidase_S51_cyanophycinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032067">
        <property type="entry name" value="Cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02069">
        <property type="entry name" value="cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR032067-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO53154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="30270" checksum="52A5BA74B8B0E3A6" modified="2016-09-07" version="1">MDEKIEGNLIIIGGAEDKKGDKEILKRVADFINKDTDMLLIATIATECPDESYSKYNKVFSGLGIKNIEKLDITNREDACNKKNVDLIKRCNLLFFTGGDQLRITSILGGTPVYDALKDICSEGKVIAGTSAGASVMSHTMIVQGEDEESPRKCTLKMSPGLGLIDSVIIDQHFAQRGRIGRLLTAVAQNPEVLGIGIDEDTAIVVSDKGIAEVIGSGAVYFLDGSSIIYSNVSEQYCDEVLSMFNVKLHVLKEGNKFDLIKKVPFEEDNLKNENTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FU94</accession>
    <name>A0A174FU94_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="9">CMK</shortName>
            <ecNumber evidence="2 9">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ipk</name>
        <name evidence="9" type="synonym">ispE</name>
        <name evidence="12" type="ORF">ERS852471_01737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 9"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265673.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53067">
        <property type="protein sequence ID" value="CUO53067"/>
        <property type="gene ID" value="ERS852471_01737"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="201"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO53067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="31721" checksum="E14547FDDB06429C" modified="2016-09-07" version="1">MKMKAYAKVNISLDIVGKRDDGYHLLRMIMQNIDLYDEIIVEKNNKDIIIECNKNYVPTDSRNLAYKAAIAFKERYNIAEGVKIKIFKNIPVSAGLAGGSTDAATVLKIMNKLFEVNASDEELMELGLKLGADVPYCIKGGTALCEGIGEIITPLNPFKNKIIVLVKPSFGVSTKEVYKNFNMEKVKKHPETEELIKAMDEDNLRYVAYNMKNLLENVTLKKHKVLIDLKEEMNKYGAINSMMSGSGPTVFAFFDDMLKAQKCFEKMKEKYNEVFLTRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZG6</accession>
    <name>A0A174FZG6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265723.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54226">
        <property type="protein sequence ID" value="CUO54226"/>
        <property type="gene ID" value="ERS852471_01761"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497433at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO54226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="484" mass="56010" checksum="F96ED3D82C6B1454" modified="2016-09-07" version="1">MRYKLFVVVLILNIIFIGCSKSNNLDDILVDNTFKYSGTWIVESYSSISEDEYNEAEDLTGKEVQIKKDSIKIFNSLVANVRYKLKVVDKSYVISYENNITAERFMGSKDRVDIISAIDNNITLCEFIILDDDNIVMIYRSDLIYLKKISSDTNFTVNNGNIINDNSIDDSNNSDVGVMIGLKKPRMLNEDGSYTQDEYRTIWISYKNDYINAIYEKENIIFPRINGIWSIKFKYDEIDNKHFDYFEVSTLEGKIVSNSEYNKEVSTYKSINFIGNDCIALESYRGDNFINEYHDYKIIPVDNINSNDGLTIEQLFNKDIKELYDADFKKAYENITDEDKEDYKNTVDYTNITMGRHDGKWILKGKITSVKENEDGKDFSTSIAPNTKLINFNSLLVPWKILKGEVPFLSDAYTSPNGEIAIVKYKNYLTVYRIEDGHLQGSPLINIPMKENEEIIMAEWCTSGYVDEWQKAFNDGSEIYIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G836</accession>
    <name>A0A174G836_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">folD</name>
        <name evidence="9" type="ORF">ERS852471_01813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265824.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57837">
        <property type="protein sequence ID" value="CUO57837"/>
        <property type="gene ID" value="ERS852471_01813"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="125"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO57837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="30747" checksum="5F0F55275CF17703" modified="2016-09-07" version="1">MGEIIKGKNIADKIKLDISEFVNFRKANNLIIPKIASILVGEDGGSIYYINNQEKISKSLGVGFDKILFPSSISEEELINEIIDLNNREDISGIILQLPLPKEMNEKRVISNISADKDIDCLTYENVGKLYMGEKCFLPCTPNSVIRILKSLDITLEGKRAVVIGRSNIVGKPLSTLLLNENCTVTVCHSKTKNLKDVCKEADILISAIGKPKFIDDEFVKDGAIVIDVGTSSVDGKITGDVDFDKVIDKASFVTPVPGGVGALTTTLLIKNSCEALEKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9I3</accession>
    <name>A0A174G9I3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="6" type="ORF">ERS852471_01807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265812.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57560">
        <property type="protein sequence ID" value="CUO57560"/>
        <property type="gene ID" value="ERS852471_01807"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO57560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="31804" checksum="F1AE835D8F68BE2E" modified="2016-09-07" version="1">MRNIAIALNPSKDKDGKILEKILLKLNDVFLDSKITVLNSFDISSINIDEELDLIIVLGGDGTILGVARDINDKYNYPILGVNIGNLGFLASIEIDNLDYALKKIKNNEFIIQERILLECESNIEGNFEVNKALNDIVIARGTLSRMMKFKVFIDDKLYYTFKGDGLIISTPTGSTAYSFSAGGPFVYPDMDVITITPICPHTKSMQPIVLNSKSKIEIKADSYSEEIYLTFDGQKSLKNIDKSIIKIKKAKENAKILLLDDYDYFKVLRKKILNNQVEGEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GA88</accession>
    <name>A0A174GA88_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation stage III, protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIIAE</name>
        <name evidence="3" type="ORF">ERS852471_01819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265836.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58038">
        <property type="protein sequence ID" value="CUO58038"/>
        <property type="gene ID" value="ERS852471_01819"/>
    </dbReference>
    <dbReference type="OrthoDB" id="805701at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014194">
        <property type="entry name" value="Spore_III_AE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09546">
        <property type="entry name" value="Spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02829">
        <property type="entry name" value="spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022379" evidence="2">
        <location>
            <begin position="31"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="395" mass="42499" checksum="BC23AE64EB26F96E" modified="2016-09-07" version="1">MNKKIKRIFLSLIFSIILFSFGSVTNISFAEDNITSVLGNDEIQSEVDSLYNYINTMKSDIELMNELDPVSYIKAYMEDGKGNISLSKIGGAVVSLLLKEVKSVLGLSFSIIAIGIISALLKSLQEAFNSEGISEVAFYACYALMIVILTKTFLISLDMAKDVITNVVEFMSKLLPVLVLMLGAAGGLTQAATMDPIVLGATILIPQLYLNIIIPLILSSFVLQFANNMTNGSKLSNLCDIAKKSTIWIQGIIITIFIGLLTVRGITSSTIDAVTLKTTKFAIDNFIPIVGKSFSDAISSVAGYSLIIKNAIGSIGLIVIILIILYPIIKIVLSSIIFKLSASLLEPIADKRITKSIAAAGESLTLIMSCVLCVSLMFFLLIAMMVQAGKFVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEW4</accession>
    <name>A0A174GEW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
            <ecNumber evidence="10">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_01857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EC" id="3.6.3.44" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265907.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59698">
        <property type="protein sequence ID" value="CUO59698"/>
        <property type="gene ID" value="ERS852471_01857"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="352"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="595" mass="67143" checksum="70133C3D003EE086" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGN0</accession>
    <name>A0A174GGN0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265983.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61722">
        <property type="protein sequence ID" value="CUO61722"/>
        <property type="gene ID" value="ERS852471_01906"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028937at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024997">
        <property type="entry name" value="DUF3892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13031">
        <property type="entry name" value="DUF3892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="71" mass="7772" checksum="22D3C1152C172BA9" modified="2016-09-07" version="1">MAQRITDTIKDSSGEITHYILDSGEKLEKADGVNRAKNGEIEGVIIAHSRKGEEYLRTKPDGNEGNNLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKB1</accession>
    <name>A0A174GKB1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61588">
        <property type="protein sequence ID" value="CUO61588"/>
        <property type="gene ID" value="ERS852471_01903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="53"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="24031" checksum="589A05DC76D88CAA" modified="2016-09-07" version="1">MKNGLKYITYIIVIACIIFLFKPKILKAVGWSYKDIYNVNIKTEEIESMYKDLDIQYLRYEWAEELDIDNEPTILVYHHTAIKNISPEDIDKLHKNKGWKGIGYHYYIRKDGTIYKGREDEAEGSHVKGYNKKSIGVCLEGNFEEEYLTDEQIEALKKLSIYICLKYNIKDILPHKELGNTLCPGKNFPLEEIKNDIIKELKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQH9</accession>
    <name>A0A174GQH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_01922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266018.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63180">
        <property type="protein sequence ID" value="CUO63180"/>
        <property type="gene ID" value="ERS852471_01922"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="230"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO63180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="32119" checksum="253891046D2C0355" modified="2016-09-07" version="1">MKKVDLKAIDWKAIVKEYFIITLGLILVAVGIEYFYAPNNLAAGGISGLGIVVNHFIPFLTPSVFCFFVNIALFILAFFLIGGDFGIKTLYGTYGLIFIMWVIEKFLNPVALTNDLMLASIFGPAIIAFGMAIAFNANASTGGTDIIAKLLNKYTTFNIGISLAIIDILVTVAAAIVFGVDTGFYAFLCVILNGFLIDKFIAIFNKTKQVTVISDKNDEISKFIIETLDRKCTYFKGSSANSGESKEIIYAIVKQKELNKLKDFIDKIDEKAFITIGQVDEVRGSGFPKLEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSF8</accession>
    <name>A0A174GSF8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">braC</name>
        <name evidence="5" type="ORF">ERS852471_01947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266066.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64197">
        <property type="protein sequence ID" value="CUO64197"/>
        <property type="gene ID" value="ERS852471_01947"/>
    </dbReference>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022792" evidence="3">
        <location>
            <begin position="33"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="35"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO64197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="383" mass="40390" checksum="3767292E6A409819" modified="2016-09-07" version="1">MKKRLLGGILALSMLTMGLVGCGNGQGSSDDADEIVIGAIGPLSGAASTYGQSVKNGAQVFLDKVNANGGIDGKQVVLKFEDDEADPTKSINAYDKLVNQDGVKLLLGPVTSGAANAVGPNATADGVPMITPSGTETNLTTTGGEYVFRTCYIDATQGEVISKYASENLGAKTMAILYNKDSDYSIGIAEAAKAQFESNGGTVVEYISYNDGDKDFSAQLTNIKSSNPEVLVLPDYYSVVPVIADQARKIGITSQLMGGDGWDSPELVKIGGDAVEGAVFVNHYSPDDSDPEVQEFVNSYKEKYGETPDAFAALSYSTLQLFEEAITKAGSTDGEAVKDALKNIDVDTISGNIRFDENRNPQKSVSIIKIENGEAKLETKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTC8</accession>
    <name>A0A174GTC8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cap8A_1</name>
        <name evidence="8" type="ORF">ERS852471_01955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266082.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64517">
        <property type="protein sequence ID" value="CUO64517"/>
        <property type="gene ID" value="ERS852471_01955"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO64517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="245" mass="27859" checksum="46A2A0799B29BF59" modified="2016-09-07" version="1">MDDKLFDFEEIFYLFKKKFWIIILITIITTSFGIYKVSKYQPSYSARAKIFIGKSTELMNFYSQQELEYYSQFVDLFSEVAKIDGFLDEAFEKNNIDVPSSSIASRLSFSSNSSNVPIYTISYSSYTDKDMAKILNVVCDEMIKKVKEMMPETVPSVLSKATVSTIYPDKRKLPIMAFGVGIVLSIGLILVIDYLDDRLISKKQLEKALPIPVIGEIPTHEKTFIKEDKHVSSKQAAKVAVSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZR6</accession>
    <name>A0A174GZR6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Periplasmic immunogenic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266246.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68282">
        <property type="protein sequence ID" value="CUO68282"/>
        <property type="gene ID" value="ERS852471_02037"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1825422at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="217" mass="25005" checksum="559632F9E37AB758" modified="2016-09-07" version="1">MERLITVKGIGNISVTPDLIIITMNLVSHKYNYDETMKLATESVNELEKAIEEVGFNKKDLKTTNFNITTSYKSYYDENNNYKSKFDGYKCEQDLKLEFDLDMEILSKVITAITKSKVDPRFNIRFSVKDKDEINKELLIKATENARSKAEVLTKAARVTLGRLVSIDYNWSEINIYSNTTYEIENKSYAIAETYAPSIEPEDIKISDTVAFVWEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE13</accession>
    <name>A0A174HE13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266365.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71408">
        <property type="protein sequence ID" value="CUO71408"/>
        <property type="gene ID" value="ERS852471_02106"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832083at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="35620" checksum="004DCC1C2D03A7CE" modified="2016-09-07" version="1">MSNYVEVQGKKYIYEKDYKENEHLRKSFNELANRTFGIDFEQWYQEGYWGDSYITYSLIDNGEVVSNVSVSIMEFKFKGEKKIYIQIGTVMTDERYRNKGLARYLMETVIEEWKDKCDLIYLFANDSAINFYPKFNFIEAYEYEYSIGCFTIDEESRVRKINMEDSNDKEIFKNIIENTVLFSQFAVLNNKNLVMFYCNSFMKENIYYVEDYDAIVIAEKSDEIIYILEVFGTKNIDLESIINKIVNKNTKKVVLGFTPFNTVLYDEKILKEEDTTLFVMKDKDNPLEFNNIMFPVLSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKY3</accession>
    <name>A0A174HKY3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">ERS852471_02163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266472.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73629">
        <property type="protein sequence ID" value="CUO73629"/>
        <property type="gene ID" value="ERS852471_02163"/>
    </dbReference>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO73629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="424" mass="46653" checksum="700AEF53247B83F8" modified="2016-09-07" version="1">MGNREIFEESKKYMPGGVNSPVRAYKDMGINPPVMKSGKGVIVKDEDGNEYIDFVLAWGPMILGHCNDDIVKCIQEISESSIAFGAPTELELQMGRFLCENLDNVEMVRMVNSGTEATMSAIKLARGYTGKNKIIKFAGCYHGHFDGFLVEAGSGVLTEGIAGCLGVPNESVKNTLIGVYNDIEQVRALFEAYQDDIAAVIIEPVAGNMGVIKADDKFMETLRVLCDEYGSLLIFDEVMSGFRVAFKGAQSLFDVKPDLVTYAKIMGGGLPCGAYCGRKEIMEKLAPLGGVYQAGTMSGNPVVMAAGLATLNILKENPEIYNHINKIGEKLENGLLEIAKEKNIDIVVNRVGGMMTIFFTDLAAVNTYNDVKTCDIERFKRYFLHMLKNGINLPQSQYEAVFLSSEHTEEHINKFLDAFRKFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPS0</accession>
    <name>A0A174HPS0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vhb</name>
        <name evidence="7" type="ORF">ERS852471_02258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266631.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76904">
        <property type="protein sequence ID" value="CUO76904"/>
        <property type="gene ID" value="ERS852471_02258"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026549at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO76904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="15993" checksum="DAA3F4DDDC0D2736" modified="2016-09-07" version="1">MLDQKTMDIIKSTVPALKAHGLDITKTFYKTMFERNPEVAPLFNMDRQKSGEQPKALAMSILASAQNIDNLSAIMPVVEKIAIRHCDSGVKPEHYPIVGENLLIAIKEVLGDAATDDIMDAWGKTYGVLAQVFIDVESKIYASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HSF0</accession>
    <name>A0A174HSF0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">ERS852471_02231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266576.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76000">
        <property type="protein sequence ID" value="CUO76000"/>
        <property type="gene ID" value="ERS852471_02231"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="541" mass="57817" checksum="AD89A37638BE5250" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTL4</accession>
    <name>A0A174HTL4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system N-acetylglucosamine-specific transporter subunit IIBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ptsG_2</name>
        <name evidence="15" type="ORF">ERS852471_02285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266673.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78322">
        <property type="protein sequence ID" value="CUO78322"/>
        <property type="gene ID" value="ERS852471_02285"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035550at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019866">
        <property type="term" value="C:organelle inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015572">
        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010974">
        <property type="entry name" value="PTS_IIBC_nag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01998">
        <property type="entry name" value="PTS-II-BC-nag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="401"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO78322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="483" mass="51164" checksum="57897CBB71124AA0" modified="2016-09-07" version="1">MMKYFQKLGKSLMLPVAALPVASILMGIGYWMDPSGWGANSAAAAFLIKAGSALIDNMGILFAIGVAVGMSDDNDGTAGLAGLVSWLMITTLLAPESVAMLKGIDVAEVPAAFGKIATQFTGILSGVIGATAYNKFKGTKLPAALSFFSGKRCVAIVTAGASIIAALVLLFVWPVVYGALVSFGKSIVSTGAIGSGIYAFLNRLLIPTGLHHALNSVFWFDVAGINDLGNFWAGTGTYGVVGMYMTGFFPVMMFGLPAAALAMYHTAKDNKKKAVYGLLLAAAVGSFFTGVTEPLEFAFMFLAPGLYVLHAGLTGISAFVCTLLPTRAGFNFSAGLVDYILSFKAPMAENPIILLAVGLVFAVIYYITFRFAITKFNLKTPGREEESEDEVEVKLSNNNYTEIASTILEGLGGVENIVSVDNCITRLRLEIRDNTKVNEKIIKSAGVSGIIRPGKTSIQVIIGTQVQFVADEFKLLCKTSNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HXC1</accession>
    <name>A0A174HXC1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqgN</name>
        <name evidence="4" type="ORF">ERS852471_02277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205690.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77519">
        <property type="protein sequence ID" value="CUO77519"/>
        <property type="gene ID" value="ERS852471_02277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO77519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="191" mass="22457" checksum="A86A39DCFEB56E76" modified="2016-09-07" version="1">MYKNIIRKKVLDLRHNLKKEEKKRLDRIIYESVIENDLYINANKIFIYVSYNNEVDTIDIIKNSIDNNKSVYVPKINIEDKTMKSVEIHSLNELSVNKYGILEPNIVDKNNTEEKFDIIIMPGIAFDSDGNRIGYGGGYYDKYISNLNYDVVKVALAYNFQMVNYIKAEEHDIKVNYIFTDKEMIYIENTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1D5</accession>
    <name>A0A174I1D5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bglK_3</name>
        <name evidence="1" type="ORF">ERS852471_02312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79178">
        <property type="protein sequence ID" value="CUO79178"/>
        <property type="gene ID" value="ERS852471_02312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047700">
        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="31995" checksum="940C3A84EDD92D89" modified="2016-09-07" version="1">MYLGIDIGGTFIKYALIDENNNVVEKWKKPSEMKESKDEFYDYLCDGLENYEYEAIGISAPGVIDSNSNVLSKAAPNVCVMCGTNVNEEVSKRTSKKVCTLNDAKAAGYCEFKIGNGKGTKSSAYFVIGTGIGGCICDDRGVIKGMNGIAGEFSPLLLDYKNGKGKFFATIASMSALIDIYNSKTTECLKYGTDVCEKYLNGDKIAVEAINDWVDNICVGLYNIVLFFNPQVICLGGGISEEDWFIDLVRKKFSSMKVYFMDICTTKIERCLYSNDSNILGAVLYAKENIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1M3</accession>
    <name>A0A174I1M3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-phospho-beta-D-glucosidase BglA</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglA4</name>
        <name evidence="3" type="ORF">ERS852471_02314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266719.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79258">
        <property type="protein sequence ID" value="CUO79258"/>
        <property type="gene ID" value="ERS852471_02314"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="488" mass="56198" checksum="298D5CFB8EC9B7FF" modified="2016-09-07" version="1">MSFPEGFLWGGATAANQYEGGYISGGKGLATADVITDGDQHTPRKITIELEDGTKKAINRFEDLPKGAKAYIDENIYYPSHVATDFYNHYKEDIALMAEMGFKCFRMSINWSRIFPNGDNKIPNEEGLKFYDDVFDELLKYGIEPVVTINHFDIPLNLAIEYDGWLNRKTIGFFERYCETIFNRYKNKVKYWMTFNEVNFLRDYTTLGITEASNLQRQQQAIYNLLLSSAKVVILGHKINPEFKIGLMVANILFYPETCNPNDVIKTMELDRGFKDFYLDVQVRGYYPSYKLKELERLNITLEKEDEDDEILKAGTVDYIAFSYYNSGVVSTKEDKNKTGGNQLGGVKNPYLEESQWGWPIDPQGIRIVLNRLYDKYQKPLMIVENGLGAIDNVEENGSINDEYRIDYLRKHIVEMKKAVEYDGVDLMGYTPWGCIDLVSAGTGEMKKRYGFVYVDMDDKGNGTLKRSKKKSFEWYKKVIESNGEILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2Y6</accession>
    <name>A0A174I2Y6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrA_2</name>
        <name evidence="8" type="synonym">gyrA</name>
        <name evidence="10" type="ORF">ERS852471_02380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266822.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81514">
        <property type="protein sequence ID" value="CUO81514"/>
        <property type="gene ID" value="ERS852471_02380"/>
    </dbReference>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="9">
        <location>
            <begin position="11"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="524"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO81514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="845" mass="94567" checksum="6D1A8EAF54F52C2A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBM8</accession>
    <name>A0A174IBM8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
            <ecNumber evidence="2">1.5.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfrA2</name>
        <name evidence="2" type="ORF">ERS852471_02450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.1.39" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266946.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84642">
        <property type="protein sequence ID" value="CUO84642"/>
        <property type="gene ID" value="ERS852471_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052874">
        <property type="term" value="F:FMN reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="197" mass="22101" checksum="E7B0901F5A34F5F2" modified="2016-09-07" version="1">MNEVIKCIKERRSIRKYLKKQIEEDRLDEILEAGIYAPNAGGRQSALVVVSQNEEVNERLGKINRGAFYESVPKNAKLGVSKDQPSIADDRNIKSAFYGAPTVITLFAPNNYLYTYADCAVVAQNIMISAHSLGIGSCMVGRADKTFEGEYGNDILKEWGVEEGYIPTYHIALGYYECELPQGKERKEGRIKKILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IDV6</accession>
    <name>A0A174IDV6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_14</name>
        <name evidence="2" type="ORF">ERS852471_02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205694.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83827">
        <property type="protein sequence ID" value="CUO83827"/>
        <property type="gene ID" value="ERS852471_02425"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="105" mass="11299" checksum="9BDAD8A25F4021F1" modified="2016-09-07" version="1">MENKKSLDVFNSMPVSKAILKNSVPAIAAMIMVLIYNLADTFFIGQTHDPFQVAAVSLATPVFLIFMAIGTIFGIGGTSVISRAMGEGRKDYAKKYVHSVCGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGU7</accession>
    <name>A0A174IGU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
            <ecNumber evidence="2">2.1.1.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiG</name>
        <name evidence="2" type="ORF">ERS852471_02439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.64" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266928.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84280">
        <property type="protein sequence ID" value="CUO84280"/>
        <property type="gene ID" value="ERS852471_02439"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008689">
        <property type="term" value="F:3-demethylubiquinone-9 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="234" mass="27507" checksum="DAD72C38305FA00C" modified="2016-09-07" version="1">MKAYEKLSKFYKKDWGNDSIRYIDLITNVINTLDLKITSILDVGCGTGILANELKKMNFEVSGMDISEDMINVAKETTTEIEFIVADMRNFDMKKKFDMITCAFDAINYITTDEDMENAMSSIYNNLNENGFFIFDVNTPYLYEDKHFGVINRVFDNIHFKQILEYDKTTQIATTLFDFGNNELENHILRAYSVEKMDEYLLKSGFEIVGRYKNFRMFPIEDRTYKVFYVAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174II53</accession>
    <name>A0A174II53_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266950.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84735">
        <property type="protein sequence ID" value="CUO84735"/>
        <property type="gene ID" value="ERS852471_02452"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO84735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="21594" checksum="556DE337CA1CB05A" modified="2016-09-07" version="1">MVDYSNILDDDCCGCSDFSDFSSYDNFDDECNRCEDILNTNFASDCTNNSNFDVDLRTELIIKESPQTICNVLQELCNQKIKIDGFEIQAICDHCSVFRFVVGSDNCQKLTDIQVAKSILSTLDISYLDDAIFKVTSTRNSRVNLANLYCALQRNAQVNAAYPSTTNGLYFQATPIDEALNTLKVSNCAKCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IM04</accession>
    <name>A0A174IM04_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent glyceraldehyde-3-phosphate dehydrogenase GapN</fullName>
            <ecNumber evidence="6">1.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gapN</name>
        <name evidence="6" type="ORF">ERS852471_02471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266991.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85965">
        <property type="protein sequence ID" value="CUO85965"/>
        <property type="gene ID" value="ERS852471_02471"/>
    </dbReference>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008886">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO85965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="488" mass="53532" checksum="8D6089413BA4220A" modified="2016-09-07" version="1">MFSNLIGQERKFRNLINGKWCDSKSGSFIEIKSPTDGKVVGKIPAMTKEEVNDVVMIAQKAHNKWKDVPINEKSKILYKVADILQERIDELSDIIIREIAKDRKSAESEINRTADYIRFTADTAKNMFGETIVSDSFPGFDKNKISVVTRESMGVVLAISPFNYPINLSASKIAPALIAGNTVVLKPATQGSLCGLYLAKVFDEAGVPAGVLNTVTGRGSEIGDYIVTHPEIDFINFTGSTEVGMRIASITSMVPLLMELGGKDAAIVLDDADLDLAAANIVAGAYSYSGQRCTAVKRILVVDKVADELADKIKRKVLELKVGNPTDEGVTITPLIDDKAADFVWELIEDAREKGAHLLAGGKRENNIIYPTLFDYVTEDMRLAWEEPFGPVLPIIRVKDKEEAILIANKSEYGLQASVFTKNIDEAFYIADKLEVGTVQINNKPERGPDHFPFSGVKASGIGTQGIRYSIEAMSRRKGVIINLNNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVW4</accession>
    <name>A0A174IVW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance protein NorM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM1</name>
        <name evidence="2" type="ORF">ERS852471_02597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267201.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91534">
        <property type="protein sequence ID" value="CUO91534"/>
        <property type="gene ID" value="ERS852471_02597"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO91534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="454" mass="49734" checksum="FE5CA935D7CE89A3" modified="2016-09-07" version="1">MKKKIDLVSGNIFRTLFTLSLPILGTSFIQMAYSMVDMIWIGRVGSAAVAAIGTAGFFTWFGSSLVLVTRTGAEVGVSQAVGKKDNTLREKYVYNSLTMAIIIAIIYTLILLIFRNGLIGFFNLNDPDIISMAINYLIIISVGMIFSFLNPQFTGIITAEGNSKTPFIANTIGLVINIILDPILIFGLGPIKPLGVVGAAVATVFAQFIVTAIFIYVFIKEGYKLKVWDKKYLDFRCIKEITKWGTPNALQNCLFSFFGMLIGRIVATWGPVPIAVQKVGSQIESISWMTAGGFASALTAFTGQNYGAQKYKRVEDGYKYTLILSLALGVLTSFLLIVFGKQIFSIFIQEQDAIIQGADYLKILGYSQLFMCIEITTAGAFFGVGKTIPPSVIGIVFTGLRIPLAIYLSQASLLGINGVWWAISLTSIFKGVILVTLFIFMVLKPIKQRRMEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J180</accession>
    <name>A0A174J180_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">ERS852471_02640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267275.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93522">
        <property type="protein sequence ID" value="CUO93522"/>
        <property type="gene ID" value="ERS852471_02640"/>
    </dbReference>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO93522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="431" mass="47732" checksum="68468C20BE3DE2BC" modified="2016-09-07" version="1">MAKFDDKKQLKCSFCGKNQDQVKRLIAGPGVYICDECIDLCSEIIQDEFEESVEIDTTSLPKPAEIKNYLDQYVIGQDKAKKALSVAVYNHYKRIQSNMIEDDVELQKSNILLLGPTGSGKTLLAQTLAKFLNVPFAIADATTLTEAGYVGEDVENILLKLIQNADYDVEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQINTSNILFICGGAFDGVDKIIEKRTQSSSMGFGADIKSKANKDVGTLLKSILPGDLLKFGLIPEFVGRLPIVVTLESLDQNALINILSKPKNALVKQYSKLFEMDNVELEFTEDALKAIADEAIARKTGARGLRSIVEDMMIEIMFDIPSDENISKIIINEDTVKNKELPEVVRLPENEKRLVLKPKKAKKKKGMETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J1I0</accession>
    <name>A0A174J1I0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267223.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92116">
        <property type="protein sequence ID" value="CUO92116"/>
        <property type="gene ID" value="ERS852471_02612"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006451">
        <property type="entry name" value="Glycogen_debranch_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024742">
        <property type="entry name" value="Glycogen_debranch_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="PTHR10569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12439">
        <property type="entry name" value="GDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01561">
        <property type="entry name" value="gde_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="295"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO92116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="672" mass="77705" checksum="40A6881A3804758C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6H7</accession>
    <name>A0A174J6H7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cax</name>
        <name evidence="7" type="ORF">ERS852471_02684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267356.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95324">
        <property type="protein sequence ID" value="CUO95324"/>
        <property type="gene ID" value="ERS852471_02684"/>
    </dbReference>
    <dbReference type="OrthoDB" id="804531at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="182"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO95324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="329" mass="34998" checksum="98AD510BAC8EEF6E" modified="2016-09-07" version="1">MNYILLIIGFFLLIKGADIFVDGASGISKKLGIPSVIVGLTIVSLGTSAPELAVSIVSSLQGSNEIAVGNVLGSNIFNTLMVFGVTLIIMPLIIKKSTIKKDFLINIAVTTLFLLLTFNGILLGKENYISRFDGFILLSGCILYILFLIWTVRGQKGGKSKDVAAEMAIEDEGIEHINIPKSIISLIIGAICIVIGGNIVVDSASSIATALGMSDKLVGLTIVAMGTSLPELVTSAMAALKGEEDMALGNILGSNIFNILLIIGASSIITPMIVSSTLIVDFIFLILVTILIGILIFAHKGKEKRLGKLEGILFVSLYIGYMVYIIFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDW6</accession>
    <name>A0A174JDW6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">czrA</name>
        <name evidence="2" type="ORF">ERS852471_02693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267375.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96097">
        <property type="protein sequence ID" value="CUO96097"/>
        <property type="gene ID" value="ERS852471_02693"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="127" mass="14488" checksum="3475F272C2A51277" modified="2016-09-07" version="1">MEERIKIFKAIADETRLKILILVSHKNICAKGIAKHLNISEAAVSQHIKVLKESSLIVGYKRGYHLMYELNRESLEKSINFIKGLINDDFNLISDGLNEEENSFDISVCKNSCKSMKNCCKNILKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JG12</accession>
    <name>A0A174JG12_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holA</name>
        <name evidence="2" type="ORF">ERS852471_02704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267395.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96568">
        <property type="protein sequence ID" value="CUO96568"/>
        <property type="gene ID" value="ERS852471_02704"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="343" mass="40652" checksum="AF4051007D750505" modified="2016-09-07" version="1">MINLEQFEDEIKKNKIANSYIFCGLDEELIKESIDSIVKRTISKDSLDLNLIKLDGLQTTCQEIENACETMSFFGDKKVVIVYRANFLREKTDKEGTKIYTEVSNYVKNMTPDTILIMYYLFNDKRENPKKNKKLSSLDKYMKVVHCDKLKKDKYYKKIEDMFKDKGRAIGKIQVKYFADKVANNFDIIKREIEKLDAYAWGREITKEDIDKLLNSKSEDDIFDLVEYISQRKVEKALDLLDELLFKADQHMLIITSIQNHFKRLYEFKVYLSKGKRVDFFMSKYRLPQFVCEKIMNQCQKFNLKQLNELIKICVDTENKLKSSASDKQTEMELMLFKTFMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JH74</accession>
    <name>A0A174JH74_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267391.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96490">
        <property type="protein sequence ID" value="CUO96490"/>
        <property type="gene ID" value="ERS852471_02702"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2176587at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="12346" checksum="B39E6241B214096E" modified="2016-09-07" version="1">MERISSSFFMLALILYYIPKILKIRKNKYIKAHIAIGSVSILAMIIALIQKFGQPDFIKYIGFSIIMILIGLTGYFFKNNPKLYRKLHIIATLSFFVYLFVSIKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQF0</accession>
    <name>A0A174JQF0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Arginase</fullName>
            <ecNumber evidence="3 10">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rocF</name>
        <name evidence="11" type="ORF">ERS852471_02781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-arginine = L-ornithine + urea</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3 10"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00037">
        <property type="protein sequence ID" value="CUP00037"/>
        <property type="gene ID" value="ERS852471_02781"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP00037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="299" mass="33262" checksum="C9C210283E4EFBC7" modified="2016-09-07" version="1">MDISIIGMPLFYGCDRPGVEKGPDILRENNLDKILGKNHYVTDLGNIDVDYIESKDKFLENDKLKYLKQVVDANNRLASKVYEALTNNTLPFIIGGDHSLALGSIAGSSKYYGNDLGVIWIDAHGDINTETTSPSGNIHGMPLAASMGIGYEKLTSIFFDDFKVKPENVFIIACRDLDQGEVELIEKLKINVWNIDDIQNGNLDQIIADLLSMIKENNIKNIHLSYDIDCLDPEYVPGTGTPVENGLTFEESKKLLKSILGTSLVKSIDFVEYNPELDLNNKTKETCIELLNIISAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZW7</accession>
    <name>A0A174JZW7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BFD-like iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267735.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05292">
        <property type="protein sequence ID" value="CUP05292"/>
        <property type="gene ID" value="ERS852471_02889"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1969696at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="57" mass="5985" checksum="1F4466AB2D338AE0" modified="2016-09-07" version="1">MSKVCLCRGITEEQIVEAVKNGATSFEEVKEATGAGAGGCRGGRCKGKIELIIENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K407</accession>
    <name>A0A174K407_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">slyA</name>
        <name evidence="2" type="ORF">ERS852471_02858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267679.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04165">
        <property type="protein sequence ID" value="CUP04165"/>
        <property type="gene ID" value="ERS852471_02858"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP04165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="17291" checksum="2F6911AB91C7C63D" modified="2016-09-07" version="1">MNDKLVKEIFDACFIAKKVTEMMPELPKDMKPRHIHVIDAIYTCKKNKELVCVSDISNALNITTPSVTKLIKELEKKDVVEKIECKEDKRITYLELTTYGKELYKVFVEEYHSKVAKVLNNISDEEAKTFIKVADEVYSLIKNNIMEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5A5</accession>
    <name>A0A174K5A5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267689.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04399">
        <property type="protein sequence ID" value="CUP04399"/>
        <property type="gene ID" value="ERS852471_02864"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1979475at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031599">
        <property type="entry name" value="ABC_tran_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16949">
        <property type="entry name" value="ABC_tran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP04399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="534" mass="59625" checksum="F9DF117ED73DADA2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K799</accession>
    <name>A0A174K799_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2935)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05638">
        <property type="protein sequence ID" value="CUP05638"/>
        <property type="gene ID" value="ERS852471_02899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021328">
        <property type="entry name" value="DUF2935"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11155">
        <property type="entry name" value="DUF2935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP05638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="103" mass="11688" checksum="7DC458C61413FE36" modified="2016-09-07" version="1">MMEHTLFIRGLLDPSENELIDTSEKFADDYSELIKKASDMSDMTISSITNETLVETTKLKEFKEAGAGGILDCKIKSIILPLLADHVLREANHYIRLLNNYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7N7</accession>
    <name>A0A174K7N7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese catalase</fullName>
            <ecNumber evidence="3">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydbD_3</name>
        <name evidence="3" type="ORF">ERS852471_02887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267732.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05219">
        <property type="protein sequence ID" value="CUP05219"/>
        <property type="gene ID" value="ERS852471_02887"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1420351at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP05219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25311" checksum="12EAE09C0DB8E99F" modified="2016-09-07" version="1">MFKHEKKLLHEVKIEKPNPQYAVLMQEQLGGGNGELKAAMQYISQSFRIKDPAIKDLFLDIGAEELSHMEMVAQTINLLNGHDVDYKRVDVGEIQTHVMFGLTPGLVNSSGAPWTANYVTVTGDLVADLLSNIASEQRAKTVYEYLYRQIYDKHVRETIDFLLNREEAHNALFREALNKVKDTGSNHDFGVTEDSKLYFDLSSPGRHFDNPNPTPPSFDNTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KFN3</accession>
    <name>A0A174KFN3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267858.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08415">
        <property type="protein sequence ID" value="CUP08415"/>
        <property type="gene ID" value="ERS852471_02959"/>
    </dbReference>
    <dbReference type="OrthoDB" id="859477at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025466">
        <property type="entry name" value="DUF4317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14199">
        <property type="entry name" value="DUF4317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP08415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="486" mass="55436" checksum="AA7D9E7B09351A04" modified="2016-09-07" version="1">MRKKDILELKKRLKKDHCTFTKMCGCYVSGEKHVILKFRETFLNLEEDDYHKYLEIAKKVMSGTIGNNILQLEFPLNEDLVNEKQISLMQLKSSALKDDALLDSFYESIIENYDYTGNFLILLYHDAYDVITKTKDNAKLDESEEVYEYVLCAICPVSLTAPGLRYYEDENRIKARDRDWVVEAPANGFIFPAFINRSSDVNSIMYYTKNAKDPHYELMEYALGCPSKQTATIQKETFQEIIKGSFGADEKKADKVFMEVQESINNMIEEYNSMYEDVADAEPILISSKDIQNILVESGVPEELAPKIEKSYAANFGNDLPLAESLIDPKVLKANEQRKKEEHLVRQVEMLQNKLEQVKQEAAADKVTNNFTEVNEGNVELENATEDNTSEALENTTEEPVENNLEENNMDATEETNYATLENDVDEAANATVESDEVAADYDVILQVKPEKIPQIKSQIIDGKKFIMIPIDEDEQTTVNGLDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGC0</accession>
    <name>A0A174KGC0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267898.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09506">
        <property type="protein sequence ID" value="CUP09506"/>
        <property type="gene ID" value="ERS852471_02975"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="148" mass="18014" checksum="9B0C33DC94764203" modified="2016-09-07" version="1">MIIRKAELKDLERIVEFNYNLAFETEDKRLDKNILRSGVRALLEDKRKGVYHVCEINDEVVGQIMYTYEWSDWRNGLFIWVQSVYVDKEYRGQGVFRRLYNHVKEMCDKDENICGVRLYVEFENHNAQKTYESLGMEKCNYYMYEYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KSZ1</accession>
    <name>A0A174KSZ1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Virulence-associated E family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13526">
        <property type="protein sequence ID" value="CUP13526"/>
        <property type="gene ID" value="ERS852471_03066"/>
    </dbReference>
    <dbReference type="OrthoDB" id="51615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="791" mass="91003" checksum="9D57EC7BB4A777ED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L0I7</accession>
    <name>A0A174L0I7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 11 methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycgJ_2</name>
        <name evidence="2" type="ORF">ERS852471_03149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268220.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18084">
        <property type="protein sequence ID" value="CUP18084"/>
        <property type="gene ID" value="ERS852471_03149"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP18084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="246" mass="28551" checksum="6CE7F876A3E96302" modified="2016-09-07" version="1">MKENKYDDNIFFQKYSQMSRSQQGVAGAGEWETLRKLLPDFKDKRVLDLGCGYGWHCIYAMEHGASSVVGVDISHKMLEVAKEKTHFPQVEYKCCAIEDVEFPEESFDVILSSLAFHYVADYEILVKKIYRILKSGGKLVFTVEHPVFTAYGTQDWHYNEKGEILHFPVDNYYYEGKRTAVFLGEKVTKYHRTLTTYLNTLLSNGFIINQIVEPQPPENMMDIPGMQDEMRRPMMLIVSANKKMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L8W7</accession>
    <name>A0A174L8W7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase domain (DUF772)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP17999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17999">
        <property type="protein sequence ID" value="CUP17999"/>
        <property type="gene ID" value="ERS852471_03147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="16311" checksum="D9B560AFA93D924C" modified="2016-09-07" version="1">MKQETFTDIEYSFRKKKTKREEFLEIMDEIIPWDEWVGVIKPYYPTGKRGRPPMGIEKMLRMYLLQIWFNLSDPATEDAIYDSYAMRKFTGIDFMTEAVPDETTLCNFRHLLEAHGLNKLFKELLLPIIRLVIPMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L9U3</accession>
    <name>A0A174L9U3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase DDE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_03151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268257.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18170">
        <property type="protein sequence ID" value="CUP18170"/>
        <property type="gene ID" value="ERS852471_03151"/>
    </dbReference>
    <dbReference type="OrthoDB" id="568762at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="138"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP18170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="327" mass="37427" checksum="CEB7BC97849FC9E5" modified="2016-09-07" version="1">MKQETFTDIEYSFRKKKTKREEFLEIMDEIIPWDEWVGVIKPYYPTGKCGRPPMGIEKMLRMYLLQIWFNLSDPATEDAIYDSYAMRKFTGIDFMTEAVPDETTLCNFRHLLEAHGLNKLFFDAINRVMVQTGHMMKGGTIVDATIINAPSSTKNAAKARDSEMHQTKKGNEWKFGMKCHIGVDAGSGLVHTITVTAANAHDITQAVALIREDDEVVYGDSGYLGIQKRPEVTSDEHLSSIDYRINRRPGRLPHVSDNAIDWERYIENRKSSVRCKVEHAFRIIKCQFGYKKTVYRGLKKNENRLYAMFACANLYALAIAGRKLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LAS2</accession>
    <name>A0A174LAS2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268322.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21263">
        <property type="protein sequence ID" value="CUP21263"/>
        <property type="gene ID" value="ERS852471_03208"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1329591at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP21263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="35108" checksum="0FF8A4238C9BD6CC" modified="2016-09-07" version="1">MFGYVTPLKPEMKIREYETFRAYYCGVCMHIKENFGNIPRMTLNYDMTFLAMLLDALHNEGPKFEMKRCIAHPHNKKPMAIKGEALSYAAAMNVSLIYYKLIDDINDDKSIKSKIGAMVLSPYKKKFNRNVTRVNDIIEENLNKLSLLEKEKNFNSIDEICDPFSLIVANILKFYPEEIDNDSEELRDNLYSLGYAIGKWIYVIDALDDLEEDINNDKFNPINYLYNKENKPYKEFIQEIKPRIEFTILNCGYNCKESLERLPLKRNKEILENIISLGMMDKYTKIVENCNCKSSKKRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHI6</accession>
    <name>A0A174LHI6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP20939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268307.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20939">
        <property type="protein sequence ID" value="CUP20939"/>
        <property type="gene ID" value="ERS852471_03201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP20939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="79" mass="8962" checksum="691788808DDBDA24" modified="2016-09-07" version="1">MGKKKNKQSKRNEQAEKILYYGIVSGLTIGVIIAFILFILTDNMFWMVLPLITLFIGFAISSLINKRNSKPRPSSNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LKN4</accession>
    <name>A0A174LKN4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmid recombination-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid mobilization pre family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002334814.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24683">
        <property type="protein sequence ID" value="CUP24683"/>
        <property type="gene ID" value="ERS852471_03270"/>
    </dbReference>
    <dbReference type="GeneID" id="60292667"/>
    <dbReference type="GeneID" id="66773961"/>
    <dbReference type="OrthoDB" id="187831at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001668">
        <property type="entry name" value="Mob_Pre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01076">
        <property type="entry name" value="Mob_Pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="236"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP24683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="314" mass="36413" checksum="F8B1E3DEEADAAD81" modified="2016-09-07" version="1">MAQHAILRFEKHKGNPARPLEAHHERQKEQYASNPDIDTSRSKYNFHIVKPEGRYYHFIQNRIEQAGCRTRKDSTRFVDTLVTASPEFFKGKSPKEIQAFFQRAADFLIGRVGRENIVSAVVHMDEKTPHLHLTFVPLTKDNRLCAKEIIGNRANLTKWQDDFHAYMVEKYPDLERGESASRTGRKHIPTRLFKQAVSLSRQARAIEATLDGINPLNAGKKKEEALSMLKKWFPQMENFSGQLKKYKVTINDLLAENEKLEARAKASEKGKMKDTMERAKLKSELDNLQRLVDRIPPDILAELKRQQRHTVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LLX6</accession>
    <name>A0A174LLX6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-glucose pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP23048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268385.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23048">
        <property type="protein sequence ID" value="CUP23048"/>
        <property type="gene ID" value="ERS852471_03243"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP23048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="308" mass="35358" checksum="E1A01568274C150F" modified="2016-09-07" version="1">MKPVLLVMAAGLGSRYGGLKQLDKIGPNGEIILELSSYDAIKAGFEKIVFILRKEIVEEFKELIGNKLSKFAEIEYVIQDMNNIPEGFEIPEGRIKPWGTGHAILCAKDVIKSPFLVINADDYYGQESFKLMYEYLNNNTEENHHAMVGYELKNTLSENGHVARGICTVENGELKEVVERTRIIKKGEAAYYTENEQEWIEVDYNSIVSMNMWGFMNSIFEITEKGFKYFLQNDLKDNPIKAEYYIPLIVSNLINSGKGKVKVMNSKDKWYGVTYQEDRVLVKEAIEKMINEGKYEKNLWEGIKRNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LMW2</accession>
    <name>A0A174LMW2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein dppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppB_3</name>
        <name evidence="7" type="ORF">ERS852471_03262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24311">
        <property type="protein sequence ID" value="CUP24311"/>
        <property type="gene ID" value="ERS852471_03262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="31832" checksum="0E7FE6D8F036ECD7" modified="2016-09-07" version="1">MNRLKYIGSTFLRMISLLIAVSIIAFILVTSSPIDPLTSYVGTESTLSKEAKDEIAEHWGLNDPPVERFITWGKNVLQGDLGTSITFKQPVSTVILERFQYSIVLMMVAWLFSGVLGFIIGILAGVYKGSIFDKIIKVFCLTLQSAPTFWIGLLVLSLFAVKLGWFPIGLAAPMGKLASDVTIGDRIYHLILPAFTLSVLSIGKITLFTRQKLIEILNSDFILFAKARGESTTQLIMRHGVRNIALPAITEQFSSFSELFGGMALAETVFSYPGLGTATTAAGLNGDVLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LNA4</accession>
    <name>A0A174LNA4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GGGtGRT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268401.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23538">
        <property type="protein sequence ID" value="CUP23538"/>
        <property type="gene ID" value="ERS852471_03252"/>
    </dbReference>
    <dbReference type="OrthoDB" id="556139at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025964">
        <property type="entry name" value="GGGtGRT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14057">
        <property type="entry name" value="GGGtGRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP23538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="35192" checksum="E09573FAA93FE061" modified="2016-09-07" version="1">MALFESYERRIGQITPVLEKYGMKTLEDAKAVCDAYGIDPYTIVKETQPIAFENAAWAYVLGAAIAIKKGCTKAADAAEAIGEGLQAFCIPGSVADDRKVGLGHGNLGAMLLREETKCFAFLAGHESFAAAEGAIKIAEKANKVRKEPLRVILNGLGKDAAKIISRINGFTYVETKFDFFTGKLEVVQSKAYSNGPRAKVNCYGSNDVREGVAIMHHEGVDVSITGNSTNPTRFQHPVAGTYKKECVEAGKKYFSVASGGGTGRTLHPDNMAAGPASYGMTDTMGRMHSDAQFAGSSSVPAHVEMMGLIGAGNNPMVGMTVAVAVAVEEHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LSU2</accession>
    <name>A0A174LSU2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">serS</name>
        <name evidence="11" type="ORF">ERS852471_03308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000042">
        <property type="protein sequence ID" value="CUP27163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268484.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27163">
        <property type="protein sequence ID" value="CUP27163"/>
        <property type="gene ID" value="ERS852471_03308"/>
    </dbReference>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="143"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP27163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="425" mass="48469" checksum="70592CED407C08C8" modified="2016-09-07" version="1">MLDLKFLRENPEIVKQNIKNKFQDKKLPLVDEVIALDAESRATQQEADSLRSNRKTISKQIGALMGQGKREEAEELKAKVNEQAARLAELEVKETELQEKIREIMLVIPNIIDPTVPIGKDDSENVEVEKFGEPVVPEFEIPYHTEIMEKLNGIDLDSARKVAGNGFYYLMGNIARLQSGILSYARDFMINKGFTYCIPPFMIRSEVVTGVMSFAEMESMMYKIEGEDLYLIGTSEHSMIGKFIDTIIKEDSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEESKEWFEKLWKYTVELFRSLDVPVRTLECCSGDLADLKVKSIDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVNGENGKYFAHTLNNTVVAPPRMLIAFLENNLNEDGSINIPEALRPYMGGMDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LTU0</accession>
    <name>A0A174LTU0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase, GlgD subunit</fullName>
            <ecNumber evidence="3">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgC_2</name>
        <name evidence="3" type="ORF">ERS852471_03276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000037">
        <property type="protein sequence ID" value="CUP25130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268438.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25130">
        <property type="protein sequence ID" value="CUP25130"/>
        <property type="gene ID" value="ERS852471_03276"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP25130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="368" mass="42439" checksum="77031ED5849FC1A5" modified="2016-09-07" version="1">MNNCIGIINLDENEQRINELTRHRSLASLPIAGRYRVIDFVLSNMTNSGVENIGIFTKNKSRSLMDHLTNGRPWDLHRKNDGLRVFNFADLDPSHDDIHNFWENIDFLEYSRRDYVLISSSYMICNIDYNEVLNYHREQGNDITIVYKNVKDCKENFTDCEVLNLDDNSNVISIGENISYRSNSNINMEMYIMKKSLFIDIIYKSIKSGMYKKVKQFIGDNLKDLKVRGYEFKGYLACINSIKAYYDANMDFLKEKVSKELFYSNSPIYTKPKDECPTQYTENSSVVNSIIANGSYIEGTVRNCVIGRKVFIGKDSVLENCVILQNGMIEDGVKMNRVITDKGVVIKKGEELKGLEDNPVTIPKKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LYK8</accession>
    <name>A0A174LYK8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000041">
        <property type="protein sequence ID" value="CUP26579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26579">
        <property type="protein sequence ID" value="CUP26579"/>
        <property type="gene ID" value="ERS852471_03297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP26579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="15934" checksum="337174ABA46063FF" modified="2016-09-07" version="1">MVDEDLFNLIKDSLNLTKGFSSSLNNDENKNHKATKDEASNDDLSLVNVLVNQLNTKDEQIAKLTKMLEDANAKRDELSGHIAQLLENEQILRREQSKLLTPADPVEEETAVADSSVGNQEEIDNVQPENERKKKWWKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XD24</accession>
    <name>A0A173XD24_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">clpA</name>
        <name evidence="8" type="ORF">ERS852471_00008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262678.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49210">
        <property type="protein sequence ID" value="CUN49210"/>
        <property type="gene ID" value="ERS852471_00008"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="207"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="487"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="654"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN49210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="743" mass="83615" checksum="1E279358F48F3418" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFG4</accession>
    <name>A0A173XFG4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureF_1</name>
        <name evidence="3" type="synonym">ureF</name>
        <name evidence="4" type="ORF">ERS852471_00018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262686.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49766">
        <property type="protein sequence ID" value="CUN49766"/>
        <property type="gene ID" value="ERS852471_00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN49766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="26470" checksum="278FF261B7D8AB8E" modified="2016-09-07" version="1">MDKSLKMLQILQLCDSNFPIGSFNHSYGMETYLRNNVIDDAKSFSKWVDLFLKHQFITSDGLAIRMLYEALENGDVDKVWEIDNLLIAQTVAKETRNAAKLVASRMIKIYLDLYEIENLKIYAKKIASKEVYGHPAIVFGLLMHDLEMSKEEAIKLHMYSTVSTIIQNAVRAIPLGQKDGQLLVKEYSEKFNHYYKLIEELDFDSFGANTPGIELSQINHETLVFRLFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XH01</accession>
    <name>A0A173XH01_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">appA_1</name>
        <name evidence="3" type="ORF">ERS852471_00021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262692.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49925">
        <property type="protein sequence ID" value="CUN49925"/>
        <property type="gene ID" value="ERS852471_00021"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015443" evidence="1">
        <location>
            <begin position="28"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="79"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="521" mass="59385" checksum="77CDD8D4B1AD78A8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKK1</accession>
    <name>A0A173XKK1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51155">
        <property type="protein sequence ID" value="CUN51155"/>
        <property type="gene ID" value="ERS852471_00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="35" mass="4021" checksum="C599746C759CBABA" modified="2016-09-07" version="1">MLDFAKAAFPWILYGLGVAIYIKYMNSKAKPKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMY4</accession>
    <name>A0A173XMY4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262754.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52306">
        <property type="protein sequence ID" value="CUN52306"/>
        <property type="gene ID" value="ERS852471_00059"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366413at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="550"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN52306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="635" mass="71743" checksum="6263AB5CAF510FCB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPQ9</accession>
    <name>A0A173XPQ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262766.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52565">
        <property type="protein sequence ID" value="CUN52565"/>
        <property type="gene ID" value="ERS852471_00066"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1962040at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="312" mass="36071" checksum="0D90C1B71F0F3475" modified="2016-09-07" version="1">MKDENLISTIFNDKNLNKDERYMILTLKYYDNDGDNIIKVTLRELSNVFGITRISKVQSILKALVDKGYISTEKTIGKATNYSFVKEGLIFKNNEDISNDQIAPMAEKVCTESNAQIEPMVEKVCTKSNAQIVPKAEKIYTKSNDPIEESNKKILSESIEKCNCYKSRMGTKSSKIDSLTGVYNSENSLSDRDKDDNINSYINNKLYINIFNAWNKININKEPHINPKITDAINTASKIYLEEQIVQAIENYSKVYHSNHYYNHPWKIVNFLSRPNGMKRFIDTGDIWLSYKDKYEDEELYGGDFDIEKYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XT84</accession>
    <name>A0A173XT84_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262833.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54166">
        <property type="protein sequence ID" value="CUN54166"/>
        <property type="gene ID" value="ERS852471_00101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="555264at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="505" mass="57379" checksum="B26638426B924128" modified="2016-09-07" version="1">MYRFKKLNPTDGFDFNNLDNARQNNYAWAIAELGDYIYVGTGRNVPLTILQSIAPDINIPAILKATNQDNLAEIWRYKKNGELPWERVYKAKPGSGITGFRFMINAKPAGSAQCLYASTYGNQVKVIKSYNGINWFVMPYDTLIGNSSRYMVTIKDKLYLAVVDEINSSETPFLYRSKDPEFYPWENVTDTTNPDFDPDKNPQGSIANMAIFNNKLYVSTSKSSGVQVWRSNKEVPEMNDWTLIVDNGFGDSENQLSLSIGVFNDYIYVSGIKAPPLSWAIPVGFDMIRIDKADNWQLVVGGRPLTPVKPSKGIRNKSLSGYTSGFNNPFNVYAWQIQEYNNSLLVSTFDDSSNMEVILNTVLANKEYLINEIGESDTETLIKIYQKIVKLLAETKYPIGFDLYRSINGRYFTPLLKNGINNMNNYGGRILYVGKDNKLIIGTSNPFDGCQIWRCTEDCNCRDNYKQHSTDIDNNSNLNEIEKTIYENFNFLKSTLTRIANLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XX32</accession>
    <name>A0A173XX32_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prkC_1</name>
        <name evidence="5" type="ORF">ERS852471_00119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262865.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54988">
        <property type="protein sequence ID" value="CUN54988"/>
        <property type="gene ID" value="ERS852471_00119"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN54988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="42059" checksum="7B36BF837C984144" modified="2016-09-07" version="1">MMWTTKSSKIPNVQIFVNENGEEVVSPIKIGGRYTVYDILSVSGGFGVILKAKDTRLGDRTVLVKARRYDKENGLFSYEKDRSRIDRIEKIRKVTRFEYNCLIDFKTLGEGRIPNVNDIVEDFCPSIYGPHLSTDGKVFVCTDYVAYNEPYIIMQMINGINLGEYLKSGIRNIMLSRNYKFYKSWERDVLQYSLQLATILGGFHKKDKENYNRYYIYQDLKPENIIITDDLFLTLLDFGAMTMVIEDNQGNARSNIEGCGSAGVGTWGYKAPEMNNPSKLAKLDRRVDIYSLGATMYHMLTGENLSLTLKDEYGRIPVDNLKKFSCTEYTYNIVKKCTEYNANERYNDMIEAKNDIYKSFMSIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y817</accession>
    <name>A0A173Y817_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Guanine deaminase</fullName>
            <shortName evidence="5">Guanase</shortName>
            <ecNumber evidence="3 5">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaD</name>
        <name evidence="7" type="ORF">ERS852471_00217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanine + H(+) + H2O = NH4(+) + xanthine</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263045.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60009">
        <property type="protein sequence ID" value="CUN60009"/>
        <property type="gene ID" value="ERS852471_00217"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="59"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN60009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="48366" checksum="171EABFF50B41B7A" modified="2016-09-07" version="1">MSNIYCVKGDILYTKKFGTFETIYNGYILIKENKVKRVYEELPDEFSNIKVVDYSNLLIIPGLVDLHLHAPQFPNIGLGLDKELIPWLESYTFPEESKYNNLEYAKKVYSKLIKEIWKHGTTRCCIFATIHKESSKLLMDLFNKSGLGAYIGKVNMDYNSPDTLIENTNKSINDTVEIIEEYKDKYALVKPIITPRFVPSCSDKLLKSLGELAMKYNIPVQSHLSENVGEINMVADRYPSEPNYASVYNSSNLLGQTKTIMAHCVHLTEEEISLLAQQNVYVAHCPTSNVNLSSGIAPIRKLIENGIKVGLATDISGGHTLSMFQVMAYAMQISNLKWIESNHKDLPLTTAEIFYLVTKGGGEFFGNVGSFEEGYDFDALVIDDSNDDNFNYLTLEERLQKFIYNSDYRNIKVRYVNGNIVHEPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YDD7</accession>
    <name>A0A173YDD7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiC</name>
        <name evidence="7" type="ORF">ERS852471_00233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263075.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60985">
        <property type="protein sequence ID" value="CUN60985"/>
        <property type="gene ID" value="ERS852471_00233"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="107"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN60985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="334" mass="37119" checksum="A2842530983C9852" modified="2016-09-07" version="1">MKGYKKYYTNKIAWYVATFIIAVILNFVLPRLMPGDPVSAIAARSVAGMTDSTAIQKVYEEYAEKFSINEPMTTQFFSFIKNAVKGDFGVSFSQYPRTVSDIIKSSVWWTVCLQLPAILVGWILGNLLGAVAAYRKGIFDKGILPIFLFFSNVPAFGMAIILLFVFAVNLGWFPTSGGYGYELIPNASFTFFKSIIYHYQLPFWSIVLITVGGQAIGMRSMSIYELNADYVKYSRFLGIKDRKITKYVFRNAMLPQITGLAMSIGTMIGGALVAEIIFSYPGLGTTILNAIKGRDYPLISACTLIITIMVLLANLLVEILYGVIDPRIKASQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMA6</accession>
    <name>A0A173YMA6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263145.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64195">
        <property type="protein sequence ID" value="CUN64195"/>
        <property type="gene ID" value="ERS852471_00257"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="17963" checksum="ADCA189EA10A7FC5" modified="2016-09-07" version="1">MTNRSESESVLNKLLVQLFRDILDIEEKWLQNSEFSDLSVTEIHVIEAISLDKERTMSEVAYDLSITVGTLTTAINKLVKKGYVDRRRIEEDRRVVLVMLTDKGKEVFKYHEEFHNDMVKCTIDSFSKEEEIVLVSALKRVSEFFEEKYHLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMP6</accession>
    <name>A0A173YMP6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigK</name>
        <name evidence="9" type="ORF">ERS852471_00281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263183.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65392">
        <property type="protein sequence ID" value="CUN65392"/>
        <property type="gene ID" value="ERS852471_00281"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014209">
        <property type="entry name" value="RNA_pol_sigma-K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02846">
        <property type="entry name" value="spore_sigmaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN65392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="231" mass="26289" checksum="18083C31826EC4A8" modified="2016-09-07" version="1">MILFSNIMEFFSNNILLTGYISGNNTFPKPLDEKEEEKYLELLKEGDKRAKSILIERNLRLVAHIVKKYSFPNKDIDELISIGTVGLIKAIDSFDASKGTRLATYASRCIENEILMLFRNNKKQNSETSLQDPIGVDKEGNEICLIDVLSSDKDSVLDKVEVNLQIKALYTKMSTVLTDRESEILKMRYGLIDGRCRTQREIAGDLGISRSYVSRIEKKALKKLKKELSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPZ5</accession>
    <name>A0A173YPZ5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigG</name>
        <name evidence="8" type="ORF">ERS852471_00286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263193.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65640">
        <property type="protein sequence ID" value="CUN65640"/>
        <property type="gene ID" value="ERS852471_00286"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014212">
        <property type="entry name" value="RNA_pol_sigma-G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02850">
        <property type="entry name" value="spore_sigG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN65640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="29576" checksum="9FC7B8EDB7DAE0DF" modified="2016-09-07" version="1">MIINKVEICGVNTSKLPVLKEKEKRELLLKMREGDKTARETFIKGNLRLVLSVIQRFNNRGENVDDLFQVGCIGLMKAIDNFDLSQNVKFSTYAVPMIIGEIRRYLRDNNAIRVSRSLRDIAYKALLVRDRLVKDNNKEPTISQIAKELNIPREDVVFALDAIQDPVSLFEPIYHDGGDAIYVMDQISDSKNSDDSWLENISIKEAMKKLNDREKLILTLRFFNGRTQMEVADEIGISQAQVSRLEKTALKHMRKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUK6</accession>
    <name>A0A173YUK6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rsmB</name>
        <name evidence="13" type="ORF">ERS852471_00313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263245.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67113">
        <property type="protein sequence ID" value="CUN67113"/>
        <property type="gene ID" value="ERS852471_00313"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="12">
        <location>
            <begin position="165"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="255"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN67113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="438" mass="49644" checksum="8918AD78A869B673" modified="2016-09-07" version="1">MNSREIALNVVNRVLNEGAYSNLVLSKELNQSNLCDKDKALVTELVYGTLRRKNTLDTIISNFIRDINEMDREVLNILRIAIYQMHFLDKVPEFAACNEAVELAKKISEKDAKLVNGILRSYTKNPDDIEVKSGKVNELAYIYSYEDWFIRMIYKQYGENYGKKILAGLNQTPKVTVRVNNNKADYDEVYDKLEEMEYNIEEGYACPEAIIISGGKSVENNPLFVEGYITVQDESAMIVAPLLDVKEGDTVLDLCAAPGGKTTHIAELLNNTGKVLAFDLHENKLSLITENVERLGLNNVTVDVMDATKLNSKLIASADSVLIDVPCSGIGIIRKKPEIKWNKTRNSLKELVPVQREIMDNAWHYLKSGGTLVYSTCTLNKEENEDNINWFLNKYKDAEIEKIFLGNMENFIYNDNGSLTILPNQYMDGFFVAKLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXW2</accession>
    <name>A0A173YXW2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbgA</name>
        <name evidence="5" type="ORF">ERS852471_00347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263301.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69031">
        <property type="protein sequence ID" value="CUN69031"/>
        <property type="gene ID" value="ERS852471_00347"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1083771at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="4">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="32660" checksum="9C0B4CAD7DD586DD" modified="2016-09-07" version="1">MATINWFPGHMKKTQREIKENLKLVDAIIEIRDARIPRSSANPDIDKLCGNKPRVILLNKSDLTESKVTKAWIKELSKENVTAIEVNCLKGQGLNQIKPALEALLKEKHDRLRAKGLVKIMTRVMVVGIPNVGKSTFINKMAKNNIAKTGDRPGVTKSKQWIKTPLGIEMLDTPGVLWPKFEDETTALNLAFTGAIKDEIMDTEELSYLLVKRLQENYAKELMTRYKLEEVCEDPYDTLSAIARKRGCLMSGGRINYDRIATILLDEFRGGVIGNISLERPDDILVKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z4V8</accession>
    <name>A0A173Z4V8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70188">
        <property type="protein sequence ID" value="CUN70188"/>
        <property type="gene ID" value="ERS852471_00366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN70188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="52" mass="6356" checksum="529F297267ADAA37" modified="2016-09-07" version="1">MKKLTFILLVFLQLNLISNIVYSLSVFNAYDFKSYDYQEPTYKIMLPKWWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZB85</accession>
    <name>A0A173ZB85_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nqrB</name>
        <name evidence="10" type="synonym">rnfD</name>
        <name evidence="11" type="ORF">ERS852471_00421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263431.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72930">
        <property type="protein sequence ID" value="CUN72930"/>
        <property type="gene ID" value="ERS852471_00421"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN72930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="307" mass="32165" checksum="016BD3F4FFCC2A16" modified="2016-09-07" version="1">MEKLIVTSSPHVKSSTTTSTIMRDVIIALIPALIASNIIFGLRAGLVTAVCVASCVGFEYLSRRIMNKKNTISDLSAVVTGIILAFNLPSTMPLWMCVIGSFVAIVIVKQLFGGIGQNFANPAITARIVLLVSFGTQMTNWAAPKIAAVADAVSGATPMAQIAAGETPNLLNMFLGTTGGSLGETSALALLIGGIYLVYRKVINPIIPVAFIGTVFVFTAVLGVNPLAQILGGGLFLGAIFMATDYSTSPVTNMGKLIFGIGCGFITVLIRVFGSYPEGVSFAILLMNILVPYIDKATRLKALGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBX5</accession>
    <name>A0A173ZBX5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
            <ecNumber evidence="1">3.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hdl IVa_1</name>
        <name evidence="1" type="ORF">ERS852471_00429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73323">
        <property type="protein sequence ID" value="CUN73323"/>
        <property type="gene ID" value="ERS852471_00429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="30120" checksum="D8B437B8E5209FF2" modified="2016-09-07" version="1">MNLKTINLKNIYLYKRGIYMYKNYIFDLYGTLVDINTDEDKSELWDKLSLFYSLKGAKYKAKELKDLYSEKVKKELELINDTKYPDFSLEKVFFSLYEDKGITPSNDTIKDTAQFFRVLSIKYIRLYDGVIELLELLKAKGKKIYLLSNAQRVFTFYEMKMLGIEKYFDDIFFSADYKVCKPDSKFYRLLLDKHNLNINESIMIGNDYICDIGGANEVGLDSLYLHSNLSPEIKGELSSKYSIMDIDIEKIAQLTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0C3</accession>
    <name>A0A174A0C3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82021">
        <property type="protein sequence ID" value="CUN82021"/>
        <property type="gene ID" value="ERS852471_00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025062">
        <property type="entry name" value="DUF4003"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13170">
        <property type="entry name" value="DUF4003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN82021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="334" mass="37644" checksum="B391B08AC10E4E38" modified="2016-09-07" version="1">MRIMNEKINLFLENNKALEDVKGSWGMYGFQIKSSALTCTMKNQRVDTDRINLALDIIKKNTSMFSNFRGINKLTTAITISFEDDMEYSLKEIISIYDKLKDEFFTNEYLVMAAQVIFNARYRVNVDDSVRNTRVAYDYMKKHHRFLTGQEDIANAAIIATTSANLEETFNEIEESYQYLKDNRISYSNNIQSLSHILSLINLPSIQKCDEVLAMNSIMKEKNVPLKDYFIPMLGIITFLADNKEDFAMNIADVSMNLKKEKGFGNFALGSNFRNMISATLVSIDYLDTLDNNIKENIIINTNNIALTVSIAMQTAVLISSAAAASAAAASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7X8</accession>
    <name>A0A174A7X8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putrescine transport ATP-binding protein PotG</fullName>
            <ecNumber evidence="5">3.6.3.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fbpC2</name>
        <name evidence="5" type="ORF">ERS852471_00553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.30" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263685.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83585">
        <property type="protein sequence ID" value="CUN83585"/>
        <property type="gene ID" value="ERS852471_00553"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN83585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="39251" checksum="13D3B8E99A306C01" modified="2016-09-07" version="1">MSLLIDIEKHLPTFDLKVKVNQDKGVLGFLGASGSGKSLTLKTIAGLDKPTKGKIIVDGTEFYNSDKKINLSPQKRQVGFLFQNYALFPNMTVSENIQIGLGNLKGNEKSKLCKEYIERLDLGGLEKHYPWQLSGGQQQRVALARALVISPKILLLDEPFSALDHHLKHSMEKELMSILKDYNGNVIFVTHDIEEAFRVCDNIIVFDKGTALNNRNKLELFNSPKSYAEAKLTGCKNISPAKATSPNKVYAESWGYEYTVNSSLDADISYVGIRAHHIELSTSDDEVNSYPFIVENIIENPFDYTIYIKNPNLKTGDLIRFSLDKKKLNFKISDIINVKFPKESLFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJR9</accession>
    <name>A0A174AJR9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88139">
        <property type="protein sequence ID" value="CUN88139"/>
        <property type="gene ID" value="ERS852471_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017722" evidence="2">
        <location>
            <begin position="27"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="353" mass="36879" checksum="08BEC9BF80FD3721" modified="2016-09-07" version="1">MKAKKILSLCLAAAVIIGMVGCQSKGNDETAQSGNDTQTETPAETPAEKVTLKIGQANFAAHGTKAFAVVTTVVSGDEIVSAYIDEFQYMSADTSTGVPNSEGMADNVIEGKVLGSKRENNETYSKNMAEKAGSTVEIATNFDVIQDFVKGKKISELEELVGKSAEEVVDAVTGATLADTTGYIQAVLEAAKQADSTTGVEFDGNVEDLTLAQTYSAAHGTKSFTITSVLVNGDEVVLAYIDELQYMAADTTTGVANSDADLAENYAEGKVLGSKRANAESYSKNMAEKAGSTVAIDANFDAIQEFVEGKKISELEEVTGKTAEEVIDAVSGCTLADTTGYITAVIEAAKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANL2</accession>
    <name>A0A174ANL2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">luxQ_2</name>
        <name evidence="8" type="ORF">ERS852471_00647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN90037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263860.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90037">
        <property type="protein sequence ID" value="CUN90037"/>
        <property type="gene ID" value="ERS852471_00647"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="859"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN90037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123041" checksum="9023A763F5EDF68C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AYZ6</accession>
    <name>A0A174AYZ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852471_00680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN93817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263940.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93817">
        <property type="protein sequence ID" value="CUN93817"/>
        <property type="gene ID" value="ERS852471_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN93817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="178" mass="19405" checksum="C6F69FAA461731B7" modified="2016-09-07" version="1">MKQLLDLFFTFARIGGLTFGGGYAMLPILQREVVEKRKWVTNEEIMDYYAIGQCTPGIIAVNTATFIGQKCAGNIGGIVATLGVVFPSLIIITLIAAFLQNFADLAIVKNAFAGIRICVSVLIINAVIKLWKSSVIDIATTIIFFIIFIAAIFTNLSPIVFVLFAGIAGVILKWRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0U8</accession>
    <name>A0A174B0U8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ohrR</name>
        <name evidence="2" type="ORF">ERS852471_00691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN94447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263956.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94447">
        <property type="protein sequence ID" value="CUN94447"/>
        <property type="gene ID" value="ERS852471_00691"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="146" mass="16839" checksum="8922953A2C4B363F" modified="2016-09-07" version="1">MDNTNLNNISNDLYMLLLSLNKRIFNHEEMLKNCNLPPSHVKALFYLIHNGPRAISQIGNDLSISKPNMTPIIDKLVSEGLINRFQDPNDRRVIRIQATEAACNFLKEREQRVKSNLIKKISPLSDDDLKELEESVKKMQKILLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B8E8</accession>
    <name>A0A174B8E8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0597 protein ERS852471_00733</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0597 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97077">
        <property type="protein sequence ID" value="CUN97077"/>
        <property type="gene ID" value="ERS852471_00733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01845">
        <property type="entry name" value="UPF0597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006054">
        <property type="entry name" value="UCP006054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="142"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN97077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="45635" checksum="286F280D505F2F7F" modified="2016-09-07" version="1">MLDEKIYNGYLEILKEEIVPAMGCTEPIAIAYASAKAKEVLGEMPKKVIVWCSGNIIKNAKCVTVPNTGDLVGIKASAIIGILAGDASKGLEVINVVDDVSIEKANELVTTDYCEVKRLDTEVQLHILVEAYGENDKVTVETKYAHTNICKITKNDEVLLEVEESPDKYLGVFVDRGILNVKDIYEFANTVKIEDVKELLDKQIAYNISIAEEGLKGTYGIGIGKVILESFPGDSVVTKLKAYAAAASEARMTGSSLPVMTNSGSGNQGMTTSIPVIIYAKEKGLTDEQLYRGLVFSNLMTIHQKTGIGRLSAFCGAVSAGCASGAAITYLEGGSLEQINKTVTNTLANISGIVCDGAKASCAAKIATSIDAAMMAHYLAMSDQSYRANTGILKEDIEDTIIAVGRLGKEGMKETDKKILDIMLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9S6</accession>
    <name>A0A174B9S6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264022.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96969">
        <property type="protein sequence ID" value="CUN96969"/>
        <property type="gene ID" value="ERS852471_00731"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1892710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="20317" checksum="7D0750534224E292" modified="2016-09-07" version="1">MDYYKMFDDFMKNCGYDFSEYRDDNSSDNEEAPPGVADEECRCGDSDIPGGFQDLNPMLFIIIAQIIGDITASRIPFNVQNALGNWLQLIGQAILTYNAQQQYFQGGPGRYYNPIYRNASNPFCENTVDESGANTVGTSSRSSGKSSTTTSNDSNNKELQKRVESLENEIEKLKRKLDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJW1</accession>
    <name>A0A174BJW1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">map_1</name>
        <name evidence="2" type="synonym">map</name>
        <name evidence="5" type="ORF">ERS852471_00789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264135.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00010">
        <property type="protein sequence ID" value="CUO00010"/>
        <property type="gene ID" value="ERS852471_00789"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="52"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO00010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="289" mass="31867" checksum="6D7E8F9B771EF21F" modified="2016-09-07" version="1">MNINRNAPCWCGSNKKYKHCHLEFDKKLASYAQRGAIIPPRSIIKTPEQIQGIKESSKINTAVLDLVSTNIKAGMSTEEINTLVHEFTISQGAIPAPLNFQGYPKSVCTSINDEVCHGIPSPDVILENGDIINVDVSTIYNGYFSDASRMFKIGEVHPNLDKLVDVAKECLEKGLEAAKPWGFMGDIAEAVQKHAENNGYSVVREFGGHGIGLEFHEEPFVSHVGKRGTGMLLVPGMVFTIEPMINMGTPDIFIDSDDDWTVLTEDGYPSAQWEYTVLVTETGIEILTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3H6</accession>
    <name>A0A174C3H6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">haeIIIM_1</name>
        <name evidence="9" type="ORF">ERS852471_00884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264332.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06435">
        <property type="protein sequence ID" value="CUO06435"/>
        <property type="gene ID" value="ERS852471_00884"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO06435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="413" mass="47925" checksum="5113A260440A8B38" modified="2016-09-07" version="1">MIRNKLNTIELFAGCGGLVDGFEKTRKYKTLSCVEWNDKPHEVLKKRLKNKYGYVDTDKTVLRFDIQRTDELINGWKDDLEYGTNLGLKEIIGQKEVDLIVGGPPCQAYSMAGRVQDENGMHDDYRNYLFESYIKVVKVFKPKIIVFENVEGILSAKPGGINIIEKITEEFLKAGYIITNNIRKDALLDMSEFGVSQRRKRVILIGLNKEVFGDNCYEILDEFYNKRLHKFKSSKVNTVKDAIGDLPKLMPREKEEKIGKKKYSHFPEVTEYKDHYPRYHNKRDIDIFRELALDIESGRNNYKSIEALKKLYTEKTGKESNIHKYNVLRWDEPSNTIPAHLKKDGLRHIHPDSQQARTITVREAARLQSFDDDFEFSGSMSSDYEMIGNAVPPEFSRRLAEALYEVFKEHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4M3</accession>
    <name>A0A174C4M3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264340.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06656">
        <property type="protein sequence ID" value="CUO06656"/>
        <property type="gene ID" value="ERS852471_00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="87" mass="9649" checksum="B25276265546186D" modified="2016-09-07" version="1">MDVVGSTVTIENITSKNHSECGIRLREEAKVEISGNNSHENDNADIKMVVLDGASESVITDNTSKYIKTSETIDKDKKIYSIVYVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CB24</accession>
    <name>A0A174CB24_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09977">
        <property type="protein sequence ID" value="CUO09977"/>
        <property type="gene ID" value="ERS852471_00951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO09977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="18572" checksum="C2A3649812985A45" modified="2016-09-07" version="1">MGMIEIKNIRNNNEKSRITNYILRELPEWFGIEESIVEYVEEVKKYDFYGAYNNGKAVGFISIKYNNKYTAEVYLIGILKEYQNQKIGRKLIEITEKLLIEDEIKFFMVKTLGESHPDENYKITREFYKKLGFYPLEEIKEIWGESNPCLIMVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHJ3</accession>
    <name>A0A174CHJ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anion transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sdcS</name>
        <name evidence="7" type="ORF">ERS852471_00981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11410">
        <property type="protein sequence ID" value="CUO11410"/>
        <property type="gene ID" value="ERS852471_00981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="485" mass="52738" checksum="38B107548A7BA99D" modified="2016-09-07" version="1">MKTTSVSKSSSTKRDWMKILGIPVALLVFGLIITMKTPIGMTFQGKTALATFLMALVLWVSQAIPTYASALLVVVILALTGGWDQSSIFSVLGYDVIWLMLSAFVITSGMEKSGFAKRLALFVVSKFGKTAKGALLSLIFVNFLLAFVIPSTTARAALLLPITMMICKIYNAVPGESNFGRQMMLQEIHVNNIATSGILTATAAQIMAAGYIKDLAGIEVTWGKWFIAGMPIAILTMIASFVIAQVLFPLEIKKPSLSTESGQEKSLAEQYKDLGKMSKNEIKALIIFAITVFLWCTDGYHANIFGVQISLAMVAVVSAVLFYLPYIGFLNWKETKIPWELMIFSCGAYAGGLALDKSGVAAFLLNKVFGTLDLSGMNPFILFMIVMFVASFSHMVFTSKTVRTVILIPTTITLATAAGVNPLLFALPASLTICDSITLPPHCKPNLIFYSTNYFTISNQLVYGLLVLTAKWLIMEYVTSHGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZU7</accession>
    <name>A0A174CZU7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18567">
        <property type="protein sequence ID" value="CUO18567"/>
        <property type="gene ID" value="ERS852471_01093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025945">
        <property type="entry name" value="DHHW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14286">
        <property type="entry name" value="DHHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO18567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="18964" checksum="405201ECB7D1ACEF" modified="2016-09-07" version="1">MCEKLGLTPKSIDDFDIVNVTNSFYGSLSSKIGTKGKVSDSIDVYIPKESDFVVNYVSEQIKSTSLFDSEYLDKKDKYCVFSGGNHALINIKTLGDPNKKLLIIKDSYANCFLPFLTSHYGEINVVDLRYYYDDLDKLIENKEITDVLFLYNSNTFNSDDSILNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7Z3</accession>
    <name>A0A174D7Z3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proton-coupled thiamine transporter YuaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiT_1</name>
        <name evidence="2" type="ORF">ERS852471_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264674.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21741">
        <property type="protein sequence ID" value="CUO21741"/>
        <property type="gene ID" value="ERS852471_01159"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1865311at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012651">
        <property type="entry name" value="Thia_Transptr_ThiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09515">
        <property type="entry name" value="Thia_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02357">
        <property type="entry name" value="ECF_ThiT_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="21617" checksum="55DBFE52EC552F43" modified="2016-09-07" version="1">MTIIIGIAAVITFILYFLDLKKNPINTKQMVIIAMVSAISFILSLIQFIKYPQDGGISLCSMMPVMVLSLLYGRTAGLTGGIIFGLLSMLNGVYVVHPVQFLLDYILARMVLGLAGIFGNDNKVKVILGSAFAVTVSVFISFLSGVVFFGEFAPAGMGVVLYSFLYNFTTAGIEGILSIGVIALIPLERFKKQIAKDSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DF06</accession>
    <name>A0A174DF06_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar assembly protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264694.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22738">
        <property type="protein sequence ID" value="CUO22738"/>
        <property type="gene ID" value="ERS852471_01181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO22738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="23437" checksum="681B864B2379844A" modified="2016-09-07" version="1">MDKRCFNDFDDFDDFDLNEFDLDEFDLDDEENIECDRDRFRRERECDENFVSEFDEDTFTEGIENSNCNSRNGQCINAINAAFCAGKEQGFRQGRAVGLREGRREGFRAGFRKGFEEGRRVGFREGCEAGKRQGFRNGFEEGREVGRQEGREAGVRQGFREGFRAGFNEGFRRGRDCVIKKVLESCNNCRNIRNGRNCRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DI41</accession>
    <name>A0A174DI41_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264726.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25143">
        <property type="protein sequence ID" value="CUO25143"/>
        <property type="gene ID" value="ERS852471_01207"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO25143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="39120" checksum="18A974F35A4DAD7F" modified="2016-09-07" version="1">MIIIVMILWEKIIKVNNLLNKEIEIKEYTDKNFEANGIGYLKISPYIGAGYQNVHPSLIYFDKTWNGYKYWLAITPYRKGNERLENPCVMCSNDLVNWNKPKGGTNPLVSTEDVKMYHYSDPQILFNNNKLEIWYRKRTRGILGDSEVILRKLSCDGMNWSKEEVLYSSQGTFNQFMSPVVIIENDKYCIWVVDWKNKKIKYYVSKNGTEWCFIRDIIISPIEGRYVWHMDIKKTRNGFEMYFSAALGEYDNQKIAYCYSEDNVTWSKPVIVMEKGKEGAFDEDFLYRPTFIDIDNNRYIMYSARDKKGNWHCSITTCTVSEPTKLKGMIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DP67</accession>
    <name>A0A174DP67_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264742.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26069">
        <property type="protein sequence ID" value="CUO26069"/>
        <property type="gene ID" value="ERS852471_01223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="24216" checksum="883AAD1CC0755118" modified="2016-09-07" version="1">MGREILLKPIYLELSQEHTIKIKRDRYKYNREINIYGKIFYDNIPVKGAVVVLFHIIRNKKIPIRRCITDESGSYYFKFNNCSYIDEIIGITSFKELRKMNNKGYVRTKKYNIEVNDIKDIILYGKVIDNHKNPIEGAIVAAFYDDENEMQAICHTFTDKDGIYILNIKYDLYRDKKIIVKSVNTSNSIIMDSNSEVNKVRKDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DU26</accession>
    <name>A0A174DU26_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264853.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29071">
        <property type="protein sequence ID" value="CUO29071"/>
        <property type="gene ID" value="ERS852471_01287"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1565753at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO29071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="15940" checksum="768ADE3BEC564AF9" modified="2016-09-07" version="1">MSIIPEFQYLLVMPDGHVKGFNDLDTTKAYINMYYMQKVRNSTIITEVNDLTDSSEQFINTVCQNLGVIEGECRVYNTNDIIEKLQEDIVFDEEKEEVISKLLSKDINLNIYDFAIDNIFNDVEAIDIMEPYGEFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYF1</accession>
    <name>A0A174DYF1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ruvA</name>
        <name evidence="10" type="ORF">ERS852471_01288</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264855.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29115">
        <property type="protein sequence ID" value="CUO29115"/>
        <property type="gene ID" value="ERS852471_01288"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO29115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="22169" checksum="9E98A53E7F312DBC" modified="2016-09-07" version="1">MYEYIKGKYIGINKDYVIVENNGIGYKIFTSGATMAELPKVSEEVMLYLEQIVREDFIGIYGFSTREELEMFKLLLSINGVGAKAALSLLSISRINNLRYAILMGDEKHLCRAPGIGKKTAGRIILELKDKIKTDDVVEGVDIQEGFKDIAPSNANVVGEALGALLALGYSEKEAETALKKVDKTQSVENIIKESLRVLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZB9</accession>
    <name>A0A174DZB9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine and succinylornithine aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argD</name>
        <name evidence="4" type="ORF">ERS852471_01326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264921.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30794">
        <property type="protein sequence ID" value="CUO30794"/>
        <property type="gene ID" value="ERS852471_01326"/>
    </dbReference>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO30794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="394" mass="44159" checksum="4670A81E8D22E164" modified="2016-09-07" version="1">MGTLHDNDKKYILNLYNRLNLEVERADGVYLYDKNNNKYLDMYSGISVNNLGYDKEIANVIKNQVDKYIHLSNYFVSEPTVNLAKLLVDNSFASKVYFSNSGTEANEAAIKLCRKYGRKINDNKIEILSALNSFHGRTYGGLTLTGQEKYQNDFKPLLSGVNYFEFNNIESLREKVSENTCAVFLEVIQGEGGIVEVSQEFMNELVKLSKTHNFLIVIDEIQTGIGRSGDLFAFEKYNITPDIVTLAKSIGGGLPLGAMLVNEKLEEVLKVGDHGSTFGGNPVACAAGAYVLDKIVNTDLLKEVKEKSNYLLNELENIKEEFPTLIKEIRGRGMMIGIDVGENAIAIRDCALDNRLLLNVTNKTIIRLLPSLCISNSEINEFLEKFREVLKSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9G3</accession>
    <name>A0A174E9G3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ftsH_1</name>
        <name evidence="7" type="synonym">ftsH</name>
        <name evidence="10" type="ORF">ERS852471_01382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265029.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34311">
        <property type="protein sequence ID" value="CUO34311"/>
        <property type="gene ID" value="ERS852471_01382"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="190"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="600" mass="65780" checksum="0BE046175B621AE1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAX2</accession>
    <name>A0A174EAX2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein HU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hup</name>
        <name evidence="5" type="ORF">ERS852471_01398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032116936.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34793">
        <property type="protein sequence ID" value="CUO34793"/>
        <property type="gene ID" value="ERS852471_01398"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="91" mass="10138" checksum="2F6382BBC7CD2D81" modified="2016-09-07" version="1">MNKAELITKMAEKSQLTKKDAETALKAFVESVQEALENGEKVQLVGFGTFETRERAAREGRNPRTKEVISIPASVVPVFKAGKEFKEKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECL7</accession>
    <name>A0A174ECL7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">coaX</name>
        <name evidence="7" type="ORF">ERS852471_01370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265005.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33640">
        <property type="protein sequence ID" value="CUO33640"/>
        <property type="gene ID" value="ERS852471_01370"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="259" mass="28715" checksum="7474859A44BD81F5" modified="2016-09-07" version="1">MILLVDVGNTNIVIGIYNENEYIASWRISTDTKKTSDEYSIQLMQLFVQNDLDPKKVKGIIISSVVPNIMHSLENMVRKSFDIEPIIVGPGIKTGINIKYDNPKEVGADRIVNAVAANELYNRDSIIIDFGTATTYCALTKEGNYLGGCISPGIKIASDALFERAAKLPRIELEVPKNIICKNTITSMQAGILYGYIGQVEYIVKNTKEEMKRLGLEEPFVIATGGLANTIARHTDVIDEVKGDLTLEGLRIIYEKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EE33</accession>
    <name>A0A174EE33_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore cortex biosynthesis protein YabQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yabQ</name>
        <name evidence="2" type="ORF">ERS852471_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265041.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34669">
        <property type="protein sequence ID" value="CUO34669"/>
        <property type="gene ID" value="ERS852471_01395"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2074180at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014242">
        <property type="entry name" value="Spore_cortex_biosyn_YabQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019074">
        <property type="entry name" value="YabQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09578">
        <property type="entry name" value="Spore_YabQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02893">
        <property type="entry name" value="spore_yabQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14983" checksum="B66229BE2A9F2DA4" modified="2016-09-07" version="1">MPLPTSAQFNIILYSILAGILTGAMFDLYRIIRGSKVPKIIIAIEDILFWILAALVVFCFLLYTNYAFLGAYVYLFMLATLFIYLKLVSPICLKFEIKMLNFLGKMSRIVVKNVLYPFKIIFYNIMGKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJN2</accession>
    <name>A0A174EJN2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore cortex-lytic enzyme SleC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265172.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37993">
        <property type="protein sequence ID" value="CUO37993"/>
        <property type="gene ID" value="ERS852471_01469"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435850at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="341"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="445" mass="49847" checksum="82DEE626D04AB354" modified="2016-09-07" version="1">MAEKGRLKIQCYVNDTYIPVDGSKAILKPSAGQEGESKEVNLVTNSSGETEIIELDAPPFAYSQEPSRPTPYSLYDLRIERAGFQDLTVNGIQIFSQSLAIQPCYLISASDIISRKTRADIINIAPNTLNGNYPSKIPEEVDKPLPPPTSGVVLPKPVVPEYITVHDGSPNNDSAPNYKVPYKDYIKNVASCEIYSTWPESTIRANVYAIISFTLNRIYTEWYRGKGKNYDITNSTAYDHAFNYGRNLYDSISVIVDDIFSSYIRRYGRKQPLLTQYCDGKNVQCPGWMTQWGSKYLGDQGKTPYDILTHFYGDDIELVTAEVVEGSPKSYPGYDLTVGSSGPEVQTIQEQLNRIAQNYPLIPKVAVDGVYGDSTKESVKVFQSIFNLPQTGIVDYATWYKISDVYVGVTRIAELRGSVKRTFIPPVSFDIMNNKNIPSLTYFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELZ8</accession>
    <name>A0A174ELZ8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase propeptide and YPEB domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265144.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37245">
        <property type="protein sequence ID" value="CUO37245"/>
        <property type="gene ID" value="ERS852471_01453"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2038509at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020878" evidence="2">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO37245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="23162" checksum="50B3E5CA0A7B2C6C" modified="2016-09-07" version="1">MKKLSLAAIIVTVSISLIGCTNSGVANNGNGNNTESSIQDSSESSKQNNNVNNTGDISLDKAKEIALSHAGLSSDQVTFVQANKDFDDGIQKYDIEFYCNGKEYDYEINAYNGQIIQYDYDMEYDYIQNNNNQSNVNNIAKISVEEAKQIVLSHAGLTSNQVTFKRTELDFDYGIQKYEVEFYYNNREYSYEVDANTGDILAYEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EP75</accession>
    <name>A0A174EP75_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PolyA polymerase family protein</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="8" type="ORF">ERS852471_01501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39703">
        <property type="protein sequence ID" value="CUO39703"/>
        <property type="gene ID" value="ERS852471_01501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="299"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO39703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="452" mass="51585" checksum="3562E5EEDC1725F9" modified="2016-09-07" version="1">MNINIPKNVKYIIDTFYQNNYEAYMVGGCVRDSLLGLSPKDYDITTSATPNITENLFSKTIPTGIEHGTITVVIEKENFEVTTYRTEGKYVDNRRPESVHFVSNLKEDLSRRDFTINAFAYNDKAGLVDYFGGLNDLNNKIIKAVGDPNIRFQEDALRMLRAIRFSAQLNFTIETNTLNAIKGNCNLIKNISIERIRDELCKLLVSDNPSKGLILLRDTGILELVLPEINSLVQYTPLCNNHNRDVFEHTLKVINNTESDLLLRLSALFHDVGKLNTLVALPNGHHYFPEHNIESANMTKDILKRLKFDNETIDRVCAIIYDHLVLMPSYMPTDGEIKRLLNRVGPKNIFILFELQRADINSLWDPVPFLTKVDYISNKTKEILENKEPLTIKDLDIDGSILIKELDLKPGKVLGDILNYLLEKVLDDKNLNSKDKLINLSKSYLNNLNDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPW9</accession>
    <name>A0A174EPW9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265196.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38718">
        <property type="protein sequence ID" value="CUO38718"/>
        <property type="gene ID" value="ERS852471_01482"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="148" mass="17147" checksum="7F9FB7DD81AE688D" modified="2016-09-07" version="1">MDFEIKSFNDLTVDEMYEIAKSRFEVFVCEQEITSEQDFDDKDKKCHHVMLKEEGRVVAYSRIVPKGMGYDNISIGRVLVLQSHRRKGVAKKMMEASLEFIKNNLNESTVVLSAQLYVKDLYESVGFKVISDVYDEVNIPHVKMNIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUD0</accession>
    <name>A0A174EUD0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1189)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265226.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39610">
        <property type="protein sequence ID" value="CUO39610"/>
        <property type="gene ID" value="ERS852471_01499"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2140802at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009574">
        <property type="entry name" value="DUF1189"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06691">
        <property type="entry name" value="DUF1189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="260" mass="29798" checksum="318E62F3B1099D8C" modified="2016-09-07" version="1">MKEKINMINRFKWSLNPKRYIYLAKDTLGKAFLYVFILATIFGLFQGITVVSTIGVVEEVIYKAYQDGKLNFEMKNGLLNFETSPYKEEQGSTVLLVDTDKTVDEVDSLRNITVHKDLSTVILKDGIVIKNGSEEIVYKYADFGLDKIDFNNQVIDLFIKELSVLKYFMIPIIIIIKFIDMLFYSFMMSLAGLLSMLLNKQRLSYGNIFKLAMYSITLPTILGLILPIGKYTMFIGGLILIFGINFVVYDDIIKINKNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYN2</accession>
    <name>A0A174EYN2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybbH_2</name>
        <name evidence="3" type="ORF">ERS852471_01521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41768">
        <property type="protein sequence ID" value="CUO41768"/>
        <property type="gene ID" value="ERS852471_01521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="126"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="31586" checksum="759192D15870E102" modified="2016-09-07" version="1">MKGEIMSCIFKIKEGFNSFTNTEKKLANYILKNKEEVVNLSAQELSDKADISPAAVVRFSKTLGYKGFTALKVDLAKDRDERENDTSVIISEDDSINDIIRKVKVSNTSSIDETIGLLNVDTINNIVEAMVNAKRIYLFGIGASGIVAMDLQQKLLRINKNSLYQMDPHTQISSSVHITNEDVAIGISYSGETKEVNTPLKIAKENGAKTIAITRYNKNSLSKIADYSVYLPNDEKDLRVGAITSRIDALTIVDILYLGVAKNDFERTKRDIKKTRDIINRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZH4</accession>
    <name>A0A174EZH4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265284.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41956">
        <property type="protein sequence ID" value="CUO41956"/>
        <property type="gene ID" value="ERS852471_01526"/>
    </dbReference>
    <dbReference type="OrthoDB" id="912543at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO41956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="382" mass="43408" checksum="890AC2D2668AE5AD" modified="2016-09-07" version="1">MEEKKLLSIIAKGEGIKVDFKRELYLDYESCKKELAKDVCAIANSRGGRGYIIVGVEDKSREIVGVKDLNSLNEEKIQQIVSSRCEPPIPIMVEIVDVKDKKVGIIVIYDGGQKPYQIRETGAFNIRRGSTTDTMRKEELVAAFEENLLLIVETCPIMKSTIDFLNMELVSKYFQSKGIYINKENEKYLLESAGIIYLDTSNKVYRCTLGGLLVFSDINNICIPQNMVKIVDKSNDSKDNVITIGGNLLNIIHETEKELRNILKVGYPIDAVMEAVKNAVLYREYSIFNKMIEVIVTKKSVIILSPGQMIIKNNKGKNIKYNSRNMWIYEKLISLDKDNTFTNDGFGIKRMKNAFKGRGSVKLINSVVENCFKVILPYYKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9I3</accession>
    <name>A0A174F9I3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265426.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45456">
        <property type="protein sequence ID" value="CUO45456"/>
        <property type="gene ID" value="ERS852471_01599"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1507030at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021465" evidence="4">
        <location>
            <begin position="31"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1766"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="5">
        <location>
            <begin position="1456"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1540"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="625"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1544"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO45456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1790" mass="196125" checksum="9085D77886771BE1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCH5</accession>
    <name>A0A174FCH5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TagD</name>
        <name evidence="2" type="ORF">ERS852471_01618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.39" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265461.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46349">
        <property type="protein sequence ID" value="CUO46349"/>
        <property type="gene ID" value="ERS852471_01618"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006409">
        <property type="entry name" value="G3P_cytidylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01518">
        <property type="entry name" value="g3p_cytidyltrns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="15609" checksum="362B4C0F8176E456" modified="2016-09-07" version="1">MKRIITYGTYDLLHYGHINLFKRAKELGDYLIVAVSTDDFNKLKKDKVCYFSYEERKKMVESIRYVDLVIPEEEWEQKINDVDKYDVDTFVMGDDWEGKFDFLKEKCEVVYLKRTPDISTTKIKENLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHH0</accession>
    <name>A0A174FHH0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA-binding protein, YhbY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhbY</name>
        <name evidence="4" type="ORF">ERS852471_01638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265499.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48286">
        <property type="protein sequence ID" value="CUO48286"/>
        <property type="gene ID" value="ERS852471_01638"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034603at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO48286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="11270" checksum="BC73632AA1B0C794" modified="2016-09-07" version="1">MITGKQRAYLRGLANTMDPIFQIGKNGIEEAFLKQLEDALEARELIKIKVLENSGLGAREASDEICRRIGCEGIQAIGSKIVLYKKSEKKPKIEIPQGNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNG1</accession>
    <name>A0A174FNG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265623.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51764">
        <property type="protein sequence ID" value="CUO51764"/>
        <property type="gene ID" value="ERS852471_01709"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1988217at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO51764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="24596" checksum="1642E14989966788" modified="2016-09-07" version="1">MKKIGLIFIILFSLLIINGVEYECYESEKYYRDMEKFLIENYDFVQNGVKLEYITNTSIIEEKNRIIEILTNELISDIDIFNNRIVCIDEMLTYNINLIDGEKTKIEIVIMNTLSNFNSSDLRQAVENLKNSKCIDERIYYFSKVRIDEEKNILPFILDGINEDTIEEAEISNGKVLKAEFIDGSKINMGQINYDTGKYIIIGTPIIFVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPJ1</accession>
    <name>A0A174FPJ1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6 8">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rplP</name>
        <name evidence="10" type="ORF">ERS852470_02573</name>
        <name evidence="11" type="ORF">ERS852471_02500</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834855</strain>
            <strain evidence="11 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZV01000028">
        <property type="protein sequence ID" value="CUO51631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_040419026.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="84024.ERS852471_02500"/>
    <dbReference type="EnsemblBacteria" id="CUO51631">
        <property type="protein sequence ID" value="CUO51631"/>
        <property type="gene ID" value="ERS852470_02573"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87122">
        <property type="protein sequence ID" value="CUO87122"/>
        <property type="gene ID" value="ERS852471_02500"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000095558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO51631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO87122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16367" checksum="0411558E6585FDF6" modified="2016-09-07" version="1">MLMPKRVKHRKVQRGRMKGKATRGNFLAYGDFGIQAQTCGWITSNQIESARIAINRYIRRGGKLWIKVFPDKPVTEKPAETRMGSGKGSPEYWVAVVKPGRVLFELSGVNEEVAREAMRLASHKLPVKCKFVTRRDFEEMGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FY48</accession>
    <name>A0A174FY48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage II sporulation protein R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoIIR</name>
        <name evidence="1" type="ORF">ERS852471_01736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265671.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53025">
        <property type="protein sequence ID" value="CUO53025"/>
        <property type="gene ID" value="ERS852471_01736"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1300956at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014202">
        <property type="entry name" value="Spore_II_R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09551">
        <property type="entry name" value="Spore_II_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02837">
        <property type="entry name" value="spore_II_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="24507" checksum="19CEA42221D4B127" modified="2016-09-07" version="1">MKKNMFNFIIIVFIVTLFGGCSLGNNEASLDLRELNYEEVADKLIRFHVIANSDSEEDQALKLKVRDKIIDKMSIKLESVESLDDAREILNSSIEEVNSIAKEVIAEEGFDYDVKTMLSNENFPDKIYGDYIFPQGNYEAYRVIIGSGEGQNWWCVMFPPLCFVDESKNIVDTKKLDENIANIEGKTEENKKDNDKQVIFKFKVVEVFDKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6H6</accession>
    <name>A0A174G6H6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265778.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56726">
        <property type="protein sequence ID" value="CUO56726"/>
        <property type="gene ID" value="ERS852471_01790"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1936285at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="219" mass="25886" checksum="9BC63F60AF479670" modified="2016-09-07" version="1">MKKFNMDEFIWFIIQLTLIILMIYLKVSGKITYFISSKMMIYFNMSIIILMLYALAQSRKIFTVRNRNYITNKFYPILSVIVLCAVFLYVMPNYKSLKAVENNVSMLNENIYEGMIKVTNDNYEILYNMDEYNNSIIELTGFVYETNNDNEIILGREVVSCCQSDKSLIQIKVKGINNINKGTWVKVIGKVEYIDETYLECIEYEKIDEPIEIYFHEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKU6</accession>
    <name>A0A174GKU6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine nucleoside phosphorylase DeoD-type</fullName>
            <shortName evidence="4">PNP</shortName>
            <ecNumber evidence="4">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deoD_1</name>
        <name evidence="4" type="synonym">deoD</name>
        <name evidence="6" type="ORF">ERS852471_01904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265979.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61626">
        <property type="protein sequence ID" value="CUO61626"/>
        <property type="gene ID" value="ERS852471_01904"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="4">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="4">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO61626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="236" mass="26175" checksum="DA290B971EA2F5BD" modified="2016-09-07" version="1">MSKHLHIMAKEGSIAETVLLPGDPLRAKFIAENFLEDVVCYNEVRGMYGYTGTYKGKRVSVQGTGMGLPSHSIYVNELIQFYGAKRLIRIGSAGSCNDNVNVRDIVLAQSASTNSGINKRRFNGLDYAPSANFQLLYEAYNIAKAKNANVKVGNVLSSDLFYDDTNHFSLKTWAEYGVLAVEMETAELYTLAAKYGVEALSILTISDHIFKGEETSPEERQNTFTDMMEIALELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLJ4</accession>
    <name>A0A174GLJ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61896">
        <property type="protein sequence ID" value="CUO61896"/>
        <property type="gene ID" value="ERS852471_01911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="55" mass="6409" checksum="A6CEB1316389611E" modified="2016-09-07" version="1">MDNNKNRMKDRSKSKNELRKIDPTGNSEVGIENGEKIGAHAHNKKSYKTYEWMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUC1</accession>
    <name>A0A174GUC1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof family hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidA_3</name>
        <name evidence="1" type="ORF">ERS852471_01996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266153.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66123">
        <property type="protein sequence ID" value="CUO66123"/>
        <property type="gene ID" value="ERS852471_01996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="30182" checksum="10BE97B46D41A70B" modified="2016-09-07" version="1">MFKLIAIDMDGTLLRSDHTVSQYTKDILKKFSDNGTRIVISTGRPLNAVIHYINDIGIFSDDDFVICNNGASIYSIKDFSPIYSNYMDTNICKEIFDLGKSFNVAIEAFSHDFSIASEKHNDFDNGDNNDLPLKVHYVDTSNDLDSFDNLFKIMFVADEDKIDEIIPLIPSQYLENYNAIHSLPKIFEFLNKDCGKGFAISNLCKILNININDVVSFGDAPNDVDMIKMCGTGVAMGNAYDEIKEIANFITKNNDEDGVAYFLEQYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GW94</accession>
    <name>A0A174GW94_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266114.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65326">
        <property type="protein sequence ID" value="CUO65326"/>
        <property type="gene ID" value="ERS852471_01975"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1041905at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022900" evidence="1">
        <location>
            <begin position="28"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="680" mass="76894" checksum="55DE207E3921DC6E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWW5</accession>
    <name>A0A174GWW5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SynChlorMet cassette protein ScmD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205683.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65608">
        <property type="protein sequence ID" value="CUO65608"/>
        <property type="gene ID" value="ERS852471_01983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="98" mass="11474" checksum="371A69F7E2CEDFA5" modified="2016-09-07" version="1">MNFKLVKEIELETKISKNFDIDDTDLDGEKVMMNLDKGQYFMMNEVGSRIWEIIETPIHVKGIVEKLREEYDVDEQTCTDKVLEFLKSLNEADLIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6X7</accession>
    <name>A0A174H6X7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Virus attachment protein p12 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68605">
        <property type="protein sequence ID" value="CUO68605"/>
        <property type="gene ID" value="ERS852471_02045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="50" mass="5351" checksum="DD557ADFCB470806" modified="2016-09-07" version="1">MGNVIVLLIIILILALSITKVVKEKKKGVKCIGCPHSKGCSSNCNITIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HEW0</accession>
    <name>A0A174HEW0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">hemA_1</name>
        <name evidence="8" type="synonym">hemA</name>
        <name evidence="17" type="ORF">ERS852471_02158</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266462.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73452">
        <property type="protein sequence ID" value="CUO73452"/>
        <property type="gene ID" value="ERS852471_02158"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="169"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="308"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO73452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="403" mass="46986" checksum="048C8B53055B1F11" modified="2016-09-07" version="1">MIRLLAIRKNISLDIREKFVLNPKKLEEGLKALHNIFDEVVILNTCNRTEIYFNSSCEEKDEEILKKIFEALKWEYELADNCVVLDQERAIRHLMDVACGFHSKIFGEDQILGQIKNAYSKALELKTVKSILKKLFEMTISCGKEFRTKSKLYEIPVSSASIAVNEAIKNNSKKFMIIGYGDVGKLVSKYILANDFESLIIGVRDISKVNDINDDRVLAMNYEEARKHIENIDCLITCTSAPHLMIERVHIKERNTPLHIFDLSVPRDVEDSVKYIDKVYLYDIDKVSSIDDKNKEIRKEIMISNKYIIEKSIDKFNQWNKQRKISPYIKEMKEERDKVILDRINSFSHKCKNEDDIQLANTLIKSATDVYINRAIEVLKEETLKGSEEECLRILKRIFMEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFB8</accession>
    <name>A0A174HFB8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tldD_2</name>
        <name evidence="4" type="ORF">ERS852471_02111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266373.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71595">
        <property type="protein sequence ID" value="CUO71595"/>
        <property type="gene ID" value="ERS852471_02111"/>
    </dbReference>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="214"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO71595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="445" mass="50249" checksum="4C87533914002204" modified="2016-09-07" version="1">MYRFPEELYTDIRIETVKTNSITYENNELKQNKLKVEKGAFIRIFDGERWYYSSTTNIEEIQKEIDELSKLAKRNENIYDNPVVKRIEVNKGNDIKYKNNNIIEVSNDEKIKLLESYLPINNEFPEILNSRLLYKDTYTIKEIISSKGTDVTFDIQNAYIANRYQLSIDGMTQNGGETIYEDDFNKLFNKQDLFREEIIKNLEYAKNAVPVKKGVYTCILSPVVAGVFAHESFGHKSESDFMIGDEKMMEEWSIGTKVGSEILNIIDCGNIEGSGYVPYDDEGTKAKENYLIKDGILNGRLHSAYTAGALNEDVTGNSRAINFEYEPIVRMTTTYIGAGNLTKEELFNGVKEGIYIDSFIHGSGMSTFTIAPSRAYMIRDGKISEPVKVSVITGNVMSTLNEIDGLSNEVEIKSLGTGGCGKMEQWPLSVGLGGPYVRVNKINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HH21</accession>
    <name>A0A174HH21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74232">
        <property type="protein sequence ID" value="CUO74232"/>
        <property type="gene ID" value="ERS852471_02181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="50" mass="5791" checksum="3B2DA7B70356A3B5" modified="2016-09-07" version="1">MKKDRWDKNSNTSNPMQKGARRQKLHQDQDNVGNDKNSPAYKSFDGEPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HK38</accession>
    <name>A0A174HK38_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, Cof family</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywpJ_2</name>
        <name evidence="1" type="ORF">ERS852471_02153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266452.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73285">
        <property type="protein sequence ID" value="CUO73285"/>
        <property type="gene ID" value="ERS852471_02153"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="32115" checksum="D1EF4BAB8A64D5B6" modified="2016-09-07" version="1">MIKLIASDMDGTLLNSNHTISQGNIEAIRKAQELGVKFAIVTGRSYDGVKPIADEFNLDCEYILMNGSEYRDRNGNILENITIDKEKVKVVMEIMEEADLCIELFTNKGTLTSDYEKVKASIEDRVRSLNPEHSDEEIQGFLKEFIGRRKITIFNSINELMDDKIDIYKIITFNKDVELIKSIKEKLKKLPGLSVVSTFDNDIEISDMQAQKGLILAKVAEKMGLERDEVMPIGDSFNDYSMFTEFKNACAMGNAIPEIKELAGFITDTNDNDGVAKAIYRALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLU1</accession>
    <name>A0A174HLU1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="3">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lytC_3</name>
        <name evidence="3" type="ORF">ERS852471_02176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266494.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74070">
        <property type="protein sequence ID" value="CUO74070"/>
        <property type="gene ID" value="ERS852471_02176"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="133"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO74070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29018" checksum="509B71B6FC707D19" modified="2016-09-07" version="1">MSSRRRRVYRRKKRRYRRIFIINLFLIFILISLIKIVNICSGLIKSPDARMVSSDINLLEDTDVFTVCIDPGHGDWDVGAIGVNGSYEKDIVLDIALIVGELLENSGLNVVYTRNTDTLSWSDNSIENLYERVRISKDNNADLFISIHCNSTYDSSEYKGVETWYNPESEDSKALALVIQEELSNLEYTNDRGIKFYSDDAPLAVLNNNDAPSALIELGFLSNWSDENILTSKIWQKNIAEAICNAILSYKDLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HX93</accession>
    <name>A0A174HX93_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="7">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">gltX</name>
        <name evidence="11" type="ORF">ERS852471_02283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77758">
        <property type="protein sequence ID" value="CUO77758"/>
        <property type="gene ID" value="ERS852471_02283"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="9">
        <location>
            <begin position="35"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="10">
        <location>
            <begin position="510"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO77758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="553" mass="63640" checksum="4A81BC4ECF0C5897" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HXG3</accession>
    <name>A0A174HXG3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266663.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77559">
        <property type="protein sequence ID" value="CUO77559"/>
        <property type="gene ID" value="ERS852471_02278"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035505at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO77559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="32627" checksum="D4F4F97749B1A4FC" modified="2016-09-07" version="1">MKLNYIKNLNEGSLEIKPITFWKAIILSFIFDITYSFVYTPISIFVEFYRDMFFMNSWSENLLTTITDFIYQYGIMLVIIVLINRSFETNGNVLYDEKISKKKYLAGVGMIVGYICITYGVFDFLLYSLPTLNEGLYEYLEQYLLNTSYIFIFISSCIMAPFFEEILYRGILLNGLLKKYSYKKAIIYSALIFGIAHMNLPQGINAFLLGVIIGLAYYYTRSIYVCMGMHFANNFLVNFVVYPESRLWTIILFIVIPIIGLIIFIKSFRTIKNNKGIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I0K1</accession>
    <name>A0A174I0K1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3343)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266786.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80713">
        <property type="protein sequence ID" value="CUO80713"/>
        <property type="gene ID" value="ERS852471_02359"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844146at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO80713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="79" mass="9252" checksum="A2AC4281DC8ED4A6" modified="2016-09-07" version="1">MKYYIIVFKNTHTAMSGEKKLKEIGMNFRIMPTPTTITQSCGICIRLEDEESVNRIINEEVIEFKAIYKRDNGCYELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I144</accession>
    <name>A0A174I144_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ORF">ERS852471_02298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266697.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78799">
        <property type="protein sequence ID" value="CUO78799"/>
        <property type="gene ID" value="ERS852471_02298"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="81"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO78799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="21946" checksum="09A47C9803A28E34" modified="2016-09-07" version="1">MDFYPVAIEKLIEEFAKLPSIGQKTAQRLTLHILNLPEEEVKEFADALVKARGTIKYCSICGNFTDKDPCAICSNPSRDKNVICVVEQPKDIMTMEKVKEFNGSYHVLHGNLSPMQGRGPQDIKLRELVARMSADVKEVIIATNPNVEGEATAMYISRILKPLDIKVTRIASGLPVGGDLEYADEVTLSKALEGRKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I241</accession>
    <name>A0A174I241_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl esterase XynC</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xynC2</name>
        <name evidence="1" type="ORF">ERS852471_02311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266713.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79139">
        <property type="protein sequence ID" value="CUO79139"/>
        <property type="gene ID" value="ERS852471_02311"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="31011" checksum="FB000E6D4A2D1188" modified="2016-09-07" version="1">MAQLKVDFMSKTLMRTVSINVILPVDKLVFDKEEEVKPFKTLYLLHGIFGNNGDWISGTRIQSWAQEKNIAVVMPSGENKFYINNEYTCERFSDFIGEELVEMTRRMFNLSHKREDTFIAGLSMGGYGAIVNGLKFYNTFGYVAGLSSGLVLDEVVYGTEEGITAMMGGRQYYTGVFGDVSKIKGSDKDYEALAKKLSGVEAAPKIYLCCGTEDFLIDANRQFREVLIENGFDVTYEEGPGEHNWYFWDEYILKILNWLPLSESVQGINSGNVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I642</accession>
    <name>A0A174I642_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">noc</name>
        <name evidence="8" type="ORF">ERS852471_02365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266798.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80938">
        <property type="protein sequence ID" value="CUO80938"/>
        <property type="gene ID" value="ERS852471_02365"/>
    </dbReference>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023705">
        <property type="entry name" value="Nucleoid_occlusion_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04285">
        <property type="entry name" value="nucleoid_noc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="ParB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO80938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="29531" checksum="8934CE2BA7E9E1CF" modified="2016-09-07" version="1">MSKQIININVDEIFPNTYQPRRYFNEEALQELSASIREYGIIQPITVRKRGEKFELVAGERRWRAARIAELSHVPCNIIEITDTESAEIALLENLQREDLNFMEVAEAYYNLINDHKFTQEELAKRMGKNQSTIANKLRLLKLSPKVRAICLENNLTERHARALLALPNEELQLKVLDKVIKNGLNVKKTEELINSELLEKAAEERKSKRRGVMPGKLYVNTIKQVFNKFDIPAEYKLKELDDSIEITVSIPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I6U3</accession>
    <name>A0A174I6U3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YyaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266790.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80789">
        <property type="protein sequence ID" value="CUO80789"/>
        <property type="gene ID" value="ERS852471_02361"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455540at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009665">
        <property type="entry name" value="DUF1256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06866">
        <property type="entry name" value="DUF1256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02841">
        <property type="entry name" value="spore_YyaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO80789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="199" mass="22175" checksum="B4045A1971D886FA" modified="2016-09-07" version="1">MDKYFCEDSMSPTTVNKIRDYLYSKLKEPILDNRPIIFLCIGTDRCTGDSLGPLVGYKLKSEHKNNIYIYGCLETPVHSKNITTILEKIEKYFINPYIIAIDSSLGNVQNVGKIFIEEKPLNPGLALNKDLPSVGDLSITGVVNISGSLEFIVLQNTRLFTVMSLADCITNGIQKCLNKISIDFSSPNKFSISKLNKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IG18</accession>
    <name>A0A174IG18_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266916.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84010">
        <property type="protein sequence ID" value="CUO84010"/>
        <property type="gene ID" value="ERS852471_02431"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="20125" checksum="48692354F182C32E" modified="2016-09-07" version="1">MKKEENNTYVKKQITQALLKLMETHVFEEIKITNIVKEAMVGRASFYRNFTNKEDVIKQYLIQLIKEWEEKLKLEQREESDWIENLFGLYKNYSEVYKLLYRSNLSYLVLENIKEVCGPKEEQDDLQAYFNSWVAHGLFGWINEWIVRGMKESPKEMAQLIKAAEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IS32</accession>
    <name>A0A174IS32_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="8 10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">adk</name>
        <name evidence="12" type="ORF">ERS852471_02514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="8 10"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267054.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87710">
        <property type="protein sequence ID" value="CUO87710"/>
        <property type="gene ID" value="ERS852471_02514"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="11">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="8">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="8">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO87710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="23812" checksum="B6BF7543EA6A2880" modified="2016-09-07" version="1">MKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISEGTPLGIEAKSYMDKGQLVPDEVTINMVKDRLTWEDCKNGYLLDGFPRTVAQAEALEGFLADRNEKLDTALSIEVPSSFILERMTGRRVCPSCGASYHVKFNPPTKDGVCDVCGSDIVQRKDDTEETVSERLEVYERQTQPLIDFYNNKNLLSTVDGTKAINEVFESICSILGSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ISM4</accession>
    <name>A0A174ISM4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rpsK</name>
        <name evidence="10" type="ORF">ERS852471_02519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267062.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87910">
        <property type="protein sequence ID" value="CUO87910"/>
        <property type="gene ID" value="ERS852471_02519"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO87910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="131" mass="14002" checksum="580541E22308DF82" modified="2016-09-07" version="1">MAAKQVKKTRRRKERKNVEHGAAHIQSTFNNSIVTLTDAAGNALSWSSAGALGFRGSRKSTPFAAQMAAETAAKAAMEHGLKSIEVYVKGPGSGREAAIRSLQAAGLEVTLIKDVTPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IW04</accession>
    <name>A0A174IW04_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91573">
        <property type="protein sequence ID" value="CUO91573"/>
        <property type="gene ID" value="ERS852471_02598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024640" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO91573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="36" mass="3825" checksum="779DDA2AB3DDE79C" modified="2016-09-07" version="1">MGIKKTGKIAILLAASAALVASLVNDKKQKEKQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J254</accession>
    <name>A0A174J254_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267287.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93753">
        <property type="protein sequence ID" value="CUO93753"/>
        <property type="gene ID" value="ERS852471_02647"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1599160at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO93753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="35989" checksum="79C939795108B300" modified="2016-09-07" version="1">MVKFIVLEKKKIFRWLFIIILLALFLIIFFSIFFKNDSLESFISSTIHNSNDKDYNGDGILDSIVVDKKNSHYIIKVKTSKNEYVLKNDLYGDALIDLYDSVSIKITSLDLSRDGIPEIILTGFKNQKPITYIYQWCDDEFKEVFSCSKNIFGIVDSENSRTPKILYALSEKGDESTESFIFNGKTIKDITFSKLQIPGLGVIQKFIDLIQLDYEIEDAPGIFTEYINSDELGILWNLSKENYRYSFQNGYFYDINWDKNALPSSIIWRLSFEKVNSSDSTKPKEEIIFNVKTDINQYGEYKISSIKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J2S7</accession>
    <name>A0A174J2S7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
            <ecNumber evidence="5">1.4.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">puuB</name>
        <name evidence="5" type="ORF">ERS852471_02613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92147">
        <property type="protein sequence ID" value="CUO92147"/>
        <property type="gene ID" value="ERS852471_02613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
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        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="410"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO92147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="507" mass="57094" checksum="8A2548340AB4FECE" modified="2016-09-07" version="1">MNKSLWISSSQGDRYGELDEDKRVECLIVGGGIVGITTAYLLCKKGYKTTIVDADYIGYGATGRNTGKITPQHGIKYSDIYKRYGRDNAKKYYEANKEALKLIENIIEENKIECDYEKAPAYIYAEDDSDGKKVLNEFNICKEIGINCEFIMDIPLPIKSSGAIKFNVGAQFNPKKYIDALAKKVKELGGEIYEKSPMKSVDAYEDSITVHSLNGYEIKADKLIIASHYPFYDGLSFYFARLKPERSYVVAGEYDGDFPQATFINSSTPKRSLRIYNDGERRFLLIAGEGHKVAHKTEEDHYGALEQYGRDVFGVENYQYRWSTQDYITTDNVPYIGYLNSVTKNILVATGFAKWGMSNGTLAGIILSDLYIKGKSKYLNTFTPSRSDGYLTGEFFKENADVGVQYLIGKLKIASKEMPEKGFGKVVIIDKAKFGVYRDENDIFHIVDTTCTHLGCELKWNPLEKSWDCPCHGSRFGIDGDILEGPATIPLKQYGAETYNEINPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J699</accession>
    <name>A0A174J699_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">perR</name>
        <name evidence="3" type="ORF">ERS852471_02648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267289.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93806">
        <property type="protein sequence ID" value="CUO93806"/>
        <property type="gene ID" value="ERS852471_02648"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO93806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="135" mass="15428" checksum="EAB3FF40B4948E39" modified="2016-09-07" version="1">MDNITSIFKEKKLKLTPQRLAVYQYLMGTKDHPSAEAIYKALQPIYPTMSLATVYKALKTLVEVGLVQEINVGEGNFRYDATVNDHAHIQCLKCSRVDDLEIDSFPNLNQIAAENSKYEIKWNKLFFYGVCESCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JB16</accession>
    <name>A0A174JB16_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267334.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94808">
        <property type="protein sequence ID" value="CUO94808"/>
        <property type="gene ID" value="ERS852471_02670"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259071at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO94808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="651" mass="73855" checksum="F4041516A8B4D449" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JH81</accession>
    <name>A0A174JH81_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">yehU</name>
        <name evidence="15" type="ORF">ERS852471_02759</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267492.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99094">
        <property type="protein sequence ID" value="CUO99094"/>
        <property type="gene ID" value="ERS852471_02759"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="483"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO99094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="601" mass="68831" checksum="8E95C9C5FD5735C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JY10</accession>
    <name>A0A174JY10_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">ERS852471_02871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267704.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04664">
        <property type="protein sequence ID" value="CUP04664"/>
        <property type="gene ID" value="ERS852471_02871"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP04664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="306" mass="34970" checksum="FA455F2309C94146" modified="2016-09-07" version="1">MMNKHLINPMDFTIEELNEIFELAHRIISNPEEYSHVCEGKILATLFYEPSTRTKFSFEAAMMRLGGKILGFSEPNSSSAAKGETLADTIKMVSIYSDIIAMRHPKEGSAKVASMYSSVPVINAGDGGHQHPTQTLTDLLTIKTLKGRLDNHVIGICGDLKYGRTVQSLITAMSRYKNIKFVLISPKELGIPQYIREEVLNKNNIEFREVEKIEDVIEELDILYMTRIQKERFFNEDEYMRLKDSYILDAEKMKLAKEDMIIMHPLPRVNEIDVEVDKDKRAAYFKQAEFGMYVRMALMAKLLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K3B8</accession>
    <name>A0A174K3B8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrite reductase</fullName>
            <ecNumber evidence="3">1.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysI</name>
        <name evidence="3" type="ORF">ERS852471_02867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267696.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04507">
        <property type="protein sequence ID" value="CUP04507"/>
        <property type="gene ID" value="ERS852471_02867"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017220">
        <property type="entry name" value="Sulphite_reductase_assimil"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037487">
        <property type="entry name" value="Sulfite_red_assimil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="82"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP04507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="23984" checksum="AA1AEE53E8A71CF2" modified="2016-09-07" version="1">MHYGNLQKIRDGRRTYAITPDIPGGFVSAETLEKIAKVSKKYNGVLKITSGQRILITNLKEEDLPQIWDDLGMEPAVVKANSVKNVEICPAGFCKRSKYNTIGIGMKLTKKYGKKDMPCRTKIGVAGCRNSCGSVYAKDVGVIADVTGLMVVAGGSAGFNPRIADIIAKDLDEQQTLKLIDSIFDYYRENAELGEKLGFMIERLGIEKFKADVIEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEV6</accession>
    <name>A0A174KEV6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobB_2</name>
        <name evidence="3" type="synonym">cbiA</name>
        <name evidence="6" type="ORF">ERS852471_03005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267955.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10654">
        <property type="protein sequence ID" value="CUP10654"/>
        <property type="gene ID" value="ERS852471_03005"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="240"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP10654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="430" mass="48400" checksum="4E6F69A06475C876" modified="2016-09-07" version="1">MKNIIISSNCSGGGKTTFTLGLMKLLKNKGYDVQGYKVGPDYIDSGFHSEITGKESRNLDLHLMGEDGVKASFSRGNGDFGVIEGVMGLYDGIGITEKGSTYNISNILGDIPIVLVLTPKAQVATLAAEINGIKNFKNANIIGVVFNAVSPKFYELLKSTVELNCDVKVLGYIPKDESIKLESRHLGLVQSIEVNNMIEKIERCAQLIEENVDLTYIIKNSKEVKLETKDEFHLENRNLNIAVAYDEAFRFYYKENLELLEELGNVTYFSPIRDEKLPENIDFLYLGGGYPEVFKEQLSKNISMRNSIKKALEEGLKCYAECGGLMYLTEKIEDCEMVGFLKGYTYMTKSLQRFGYANVAIKGENISINCHEFHKSDVELNEESIYNVTKKSWSGDALSWNCGYKKKNTIAGYPHIHFFGNMEFLRFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KJH6</accession>
    <name>A0A174KJH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycyl-radical activating family protein</fullName>
            <ecNumber evidence="11">1.97.1.-</ecNumber>
            <ecNumber evidence="11">1.97.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hpdA</name>
        <name evidence="11" type="ORF">ERS852471_03037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="11"/>
    <dbReference type="EC" id="1.97.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268019.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12264">
        <property type="protein sequence ID" value="CUP12264"/>
        <property type="gene ID" value="ERS852471_03037"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="29384" checksum="C2196E7ADD81D44E" modified="2016-09-07" version="1">MSNLDVKGRIFDIQKFSIHDGPGIRTIVFLKGCILRCQWCCNPESQRFDIENMIVAGKNKIIGQDVTVREVLEKIKQDRAYYKRSGGGIALSGGECMCQPEFAKALLHECNEIGISTAIETTAAVDSDIVKYIIPEVDTILMDIKHTNSEKHKKFTGRDNKIILENAKIIAESDSDLIIRVPVIPTFNHTKEEIRDIARFAKTLKGVTRLHLLPYHRMGQDKYTGLDRNYILDGVETLSSDYMDMLLEVVLNEGLRGQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXT8</accession>
    <name>A0A174KXT8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ureA_2</name>
        <name evidence="4" type="synonym">ureA</name>
        <name evidence="6" type="ORF">ERS852471_03104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268143.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15591">
        <property type="protein sequence ID" value="CUP15591"/>
        <property type="gene ID" value="ERS852471_03104"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826954at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="100" mass="11226" checksum="4B2D78CC3509BF6F" modified="2016-09-07" version="1">MHLTIREQEKLMVAVAADVARKRKSKGLKLNYPEAMAIITDEMLEGAREGKTVEQLMQYGTTILSRNDVMEGVPEMIHTVQVECTFPDGTKLVTVHDPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6F5</accession>
    <name>A0A174L6F5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17139">
        <property type="protein sequence ID" value="CUP17139"/>
        <property type="gene ID" value="ERS852471_03134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="31868" checksum="3D332732269AC567" modified="2016-09-07" version="1">MKCSVLMSVYKNDDPEFLKVALESIYEKQTRKPEEIIVVFDGELNNRLYEVLNDFRKGKESIVFYYPQDINRGLGEALKIGVEKCTGDYIFRMDSDDISDPRRFEKQYLFMQNNPDIDVVGSDIAEFNISTDETMRLRICPRMHEDIVKMGKRRNPMNHVSVCMRTSALKRCGGYETLLLLEDYYLWLKMIATGCRLENINEPLVYVRVGNGFNSKRGSKTRIKGWKVLQKYMLSTRMINRFEAMTNMIYIIVFVNIPAPLKKLLYDVVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LBD6</accession>
    <name>A0A174LBD6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine import ATP-binding protein MetN</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metN3</name>
        <name evidence="8" type="ORF">ERS852471_03214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268332.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21463">
        <property type="protein sequence ID" value="CUP21463"/>
        <property type="gene ID" value="ERS852471_03214"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP21463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="35609" checksum="769B79F8B5258022" modified="2016-09-07" version="1">MIKISNIEKNFGDTKVLRGITLNINEGEIYGLIGHSGAGKSTLLRCINGLENYNDGSVIVMGKEVKDLKEKDKREFRKDLGMIFQGFNLLKRKTVFENISLPLEVWGYKKDYIKKRVDELLELVGLSDKSKSKPSELSGGQKQRVAIARALALEPKILLCDEATSALDPKTTKDILSLLNDINKKLGITIVVVTHQMEVIKQICEKVALIDGGVLVAEGKADDIFLKPGISLKKFLGEEDDDTLSHEGVNIKLFFPSKSSENALITKMARELNIDFSIVGGKLEKFRDEVLGTLTININKEDREAVMSYLSNKDIILEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LLP2</accession>
    <name>A0A174LLP2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation-specific N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cwlC</name>
        <name evidence="2" type="ORF">ERS852471_03258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268411.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23831">
        <property type="protein sequence ID" value="CUP23831"/>
        <property type="gene ID" value="ERS852471_03258"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="1">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP23831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="247" mass="27445" checksum="9B4342AABDE08A12" modified="2016-09-07" version="1">MVTYNSFIFEGHGISEKTGVYDPGAVYGTVRENDLADKIVTTAINYLKTTALSIHRDENNYADNDLDGNIYAAKAGISVHINAGGGTGTEIFVPSREKYLTEDFNLVKNISETLGIANRGVKSRDYNTGKIYLRSDGITLDYTDYYKEIRYAWGLGISLAIIEVGFIDTSDLKKIQANIDKIGFLIAQYIAKICGIELSKPGEPSITEDVYYRVICGSFKEKSNAEQRKKELETKGYSGIFVDIYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LLU4</accession>
    <name>A0A174LLU4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_03236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP22745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268372.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22745">
        <property type="protein sequence ID" value="CUP22745"/>
        <property type="gene ID" value="ERS852471_03236"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP22745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="481" mass="55710" checksum="63EE11422F42C9DA" modified="2016-09-07" version="1">MDKRPNIILIMTDEMRGDCLGYAGHPDVKTPYLDSLASKGIYFPNAYSSCPTCVPARAILHTGLSQRNTGRVGYEDRVDWNYEITMAGELTKSGYYTQCVGKMHVHPLRNYLGFNNVRLHDGYLHEYRYPNVSYGENQLIADDYFYWLKDQKGISADVVNTGLDCNGWVSRPWIYDEMSHPTNWVVTESIDFLRRRDPRKPFFLMTSFVRPHAPFDAPQYYFDLYKNMSLREPIKGDWNDKELIKKIGYRYNATTGPLDPELVREMQIGYYACITHIDHQIGRLIQALVEQRVMDNTIIIFTSDHGEMLGDHNYIQKARPYQGSIHIPMFISGPEELLGRKHCIDESLVELRDVMPTFIDIAGGKVPEVLDGESMLKEIDRKYIHGEHLYDFGQKSHQFIVTKTDKYVWFSQTGEEQYFNLIKDKDEAHNGINDLEYKDRIEELKNILIKELKESEEGYSDGEKLIVGCKTKPSLSNATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LMN5</accession>
    <name>A0A174LMN5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000034">
        <property type="protein sequence ID" value="CUP22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268383.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22980">
        <property type="protein sequence ID" value="CUP22980"/>
        <property type="gene ID" value="ERS852471_03242"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="370" mass="42463" checksum="3A49820448FF4998" modified="2016-09-07" version="1">MESNFLELTKQALDLINIEGDIVEVVPFGGGLINATFLVRTKLEGGEERKYILQRINHYIFKEVEKLMDNYCRVCDYLKDIVAKNNGDIERETITVVNAKDGRSFTQDSEGNYWRAIKFIPDTITYETISCEDDFYKAGKAFGNFQNMLADYNAELLYESIPNFHNTKERLKTFINAIKENKSGRKDKVVDEINFILERQEQASSLVDMLERGELPLRVTHNDTKISNVLLDKDTKEGICVIDLDTIMPGLSLYDFGDAIRSGATFAREDEEDLSKVFVDLGLFEAFTKGFIEGVDNGLTQKEIEMLPMGAKIITLEQGMRFLTDYLDGDLYYKTSCDDHNLVRTRTQLKLVKDLEDKWEEVNNIVKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LQ98</accession>
    <name>A0A174LQ98_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000040">
        <property type="protein sequence ID" value="CUP26362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268468.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26362">
        <property type="protein sequence ID" value="CUP26362"/>
        <property type="gene ID" value="ERS852471_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008027272" evidence="2">
        <location>
            <begin position="26"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP26362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="498" mass="49837" checksum="6645434950AD8A3C" modified="2016-09-07" version="1">MKKKASILVLTGAVTMSNMGLTTFADVKDESLLTQEINADLQNEVSINNEETFIVPEVDEQISIIEDVSDESLLIKNVSANLKNKVVVEQGGIVRVAGEDGQLGTPDDVFIVPGTYGQAPDIDQFGNVTLPTGGKVYLQNGTIVEDIGNDHSIIVPGGTVITPNGNGGAPTVNADGSVNVPEGSMVVLANGYDTTPPSGSSVSNNGNVTTASGVEIKANGTVVVPGPDGQVGTPDDVMVKPLIHPDIYGEIPTVDEFGNVTLPTGGHVLLPDGTIVTDRGADYSIIVPGGTVVTPNGNGGAPTVNADGSVNVPDGSMVVLPNGDDMTPEDGGVVKPDGSIENLDGSVIRPDGSIENPGGNGNNPGGSDDNTGGNGNNPGGSDDNTGGNGNNPGGSDDNTGGNGTNPGGSENNTGGNGTNPGGSENNTGENGTNLGGSENNTGVNETNPSESGSNTIGNVTNQGGTVVNPNTGDTSIMGTLGLGLTALLALVKNRKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LRK7</accession>
    <name>A0A174LRK7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic dipeptide transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">appA_5</name>
        <name evidence="5" type="ORF">ERS852471_03263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24360">
        <property type="protein sequence ID" value="CUP24360"/>
        <property type="gene ID" value="ERS852471_03263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008027196" evidence="3">
        <location>
            <begin position="25"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="87"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP24360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="546" mass="60503" checksum="760D643E5953EC8B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LRV0</accession>
    <name>A0A174LRV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268454.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25701">
        <property type="protein sequence ID" value="CUP25701"/>
        <property type="gene ID" value="ERS852471_03288"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2098657at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="67" mass="7201" checksum="A01397F8308707B0" modified="2016-09-07" version="1">MVKFLEKMILSDKDYEYLTKGIAIGVGTGVLVGAIIGNITLTFAAGGVIGILSAFIYSIYKRNRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LZ27</accession>
    <name>A0A174LZ27_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000042">
        <property type="protein sequence ID" value="CUP26970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268476.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26970">
        <property type="protein sequence ID" value="CUP26970"/>
        <property type="gene ID" value="ERS852471_03303"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800339at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="46"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="19550" checksum="8C2D37FDE93094CA" modified="2016-09-07" version="1">MALYRVKQFVWAAGSYFKKIDTEYVNKYLDKDEMKLFNKLNHNEKHHSIRVCKDALDICKKKNISLNTNRIAKAALLHDVGKGEFGLNLVEKSALVLLNKLTKGKIKKYNSIKQIDIYYNHAQKGADILKEFKTYDKEFLDSIRYHHSNKKISNELLDLIRESDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M5R6</accession>
    <name>A0A174M5R6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000049">
        <property type="protein sequence ID" value="CUP29109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032116763.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29109">
        <property type="protein sequence ID" value="CUP29109"/>
        <property type="gene ID" value="ERS852471_03335"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP29109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="169" mass="19438" checksum="DF516869D621362D" modified="2016-09-07" version="1">MNFSIVTLTNEDLTQYKVDMQEAFQKGFEDVFGKTEDIILPERDINHSLKAKGSVAYKAVVDGEMVGGAIVVIDEEAQHNHLDLFYVKCGIHSKGIGKRMWDEIEKLHPETKVWETCTPYFERRNIHFYVNRCGFHIVEFLNEKNPGADMPEDFIGDGGQGMFVFRKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLS9</accession>
    <name>A0A173XLS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane sensor signal transduction histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">graS_1</name>
        <name evidence="6" type="ORF">ERS852471_00057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262750.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52200">
        <property type="protein sequence ID" value="CUN52200"/>
        <property type="gene ID" value="ERS852471_00057"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="126"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN52200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="40158" checksum="076E67E30A4D9505" modified="2016-09-07" version="1">MNLKRFIRENIKCILFNCSILFFINIYFLVLNLLKDNMGEVYYLDLILVVLYIVAFIIKYRSWKERYSKLYEFVEDDNDINIDDVEGDFLEEEIIRYIINKKESKYSEVIDIKDEQIKDMEEYISRWVHEIKLPISAISMILERIDDAKISTDIKNETEKINFLVNSVMYGSRATAAAEDIFISEEKLKDIVKQAIKNNAFLLIRNSIDISLDNLDHYVYTDKKWILYVLDQLINNAIKYSKENAEIKFYAEETDKYICLNIRDNGIGIAKEDIERVFNKGFTGSNGRNTIYKSTGMGLYFSKKILDKLGNSFEVQSVKNKYTLFKIKFNKISDFTTITKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTR9</accession>
    <name>A0A173XTR9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GerA spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262881.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55362">
        <property type="protein sequence ID" value="CUN55362"/>
        <property type="gene ID" value="ERS852471_00127"/>
    </dbReference>
    <dbReference type="OrthoDB" id="509060at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN55362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="471" mass="53519" checksum="51FDBAC422BF6F2F" modified="2016-09-07" version="1">MKLTNNFKKNVELLQKELQVGKTFDVLERIIDVHNTKFYCYYLDGFVKDTNMEYVRRDMYNLKKEDFKSISSAQELIEKALSSIEASTDTDIDSIVKAVLSGQTAMLCESFNEALILDYRTYPSRGVDEPDKEKVLRGSHDGFVETIVFNTALIRRRIRDPKLIFEMHTIGQISQTDVAIGYLESKVDKKTLNKVKELIEGLKIKALTLGDESLLEVLMPKSRLNPFPKARYTERPDVVAAEIIEGKIVILIDNTPSALILPGSIFDFFQSIDDYYLPVITGNYLKMLRYLVLFVNIFLTPVYVLLTANPQWLVGKLSFLLPKDPYTIPIFIQFLIAEIAIDGLKLASLNTPNSLGTSLSIIGGLILGDYTVQTGWFTPQTILYMSIVALTSFVQPSIELGFALKFNRILLLITTGFFGAWGFIAGLVFNLIILFTTKTVTGEKYLYPLIPFNWKALKKVLFRTRKQIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTS9</accession>
    <name>A0A173XTS9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262871.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55134">
        <property type="protein sequence ID" value="CUN55134"/>
        <property type="gene ID" value="ERS852471_00122"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2206746at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN55134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="134" mass="15543" checksum="598D3BBDC5F768EC" modified="2016-09-07" version="1">MERAEVLRKLADEAVNLIKEFREEACVLGENPLCDVLVNESNDIVIFENGIKEPIEYSLSEISYIFEDDIEGFNNCGSNFNEGIELALREARLEYDKLNKEEFSNYIGRIIYAQFRCEEIYNSLLEIESITRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XW29</accession>
    <name>A0A173XW29_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate formimidoyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262899.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55819">
        <property type="protein sequence ID" value="CUN55819"/>
        <property type="gene ID" value="ERS852471_00136"/>
    </dbReference>
    <dbReference type="OrthoDB" id="780971at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="SSF55116"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FTCD" evidence="7">
        <location>
            <begin position="181"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN55819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="33501" checksum="4F7D11A3D1FB12E9" modified="2016-09-07" version="1">MAKIIECIPNFSEGRDPVIIDKIIDTLRGKEGIKLLDYSSDKDHNRTVVTFVGSPEKVYEAILNMADKVYEYIDMRKHNGEHPRMGALDVVPFVPVNDVTMEECISLANKVAKEIGDKYKVPVYLYEDAATKEERRNLATVRKGQYEGFFEKINNPEWKPDYGPSVMNAKLGCSAIGARVPLVAFNVNLDTNNIEIAQNIAKVVRHIGGGLRYVKAMPVELKERNIVQVSMNLVNYEKTAIYRAFEMIKMEAKRYGVNVIGSEVIGLVPMAALIQCAEYYLQIENFSKEQILETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y322</accession>
    <name>A0A173Y322_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262958.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57507">
        <property type="protein sequence ID" value="CUN57507"/>
        <property type="gene ID" value="ERS852471_00169"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1329591at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="297" mass="34856" checksum="322A24B1AD7E3161" modified="2016-09-07" version="1">MFGYITPLKIELKVKEFEYFRSYYHGLCYSIKNNFGNIPRLTLNYDMTFIGFILEGLSNESIIIENKRCIKHPTYDIQVIKDTNALKYAANLSVTFFDYKLKDNINDDNNKKSKVFNIFLSPYSKKAELNYANINKIIKTNLATLSSMEINKNFDTFDEVCHPFSDIMASILKNYPHTLYNDSSTLREMLYKLGYYIGKYIYLMDAFDDLEDDILSNQFNPLIVIHKLNKENYKDNLENIIAEMDFLILSCISYCKDILDSIPLIKHKEILENIVTLGMPNEFYKICNEMYKKIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3C6</accession>
    <name>A0A173Y3C6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">L-threonine dehydratase catabolic TdcB</fullName>
            <ecNumber evidence="7 13">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">thd</name>
        <name evidence="15" type="ORF">ERS852471_00181</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 13">In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="7 13"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262983.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58070">
        <property type="protein sequence ID" value="CUN58070"/>
        <property type="gene ID" value="ERS852471_00181"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00052">
        <property type="reaction ID" value="UER00507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070689">
        <property type="term" value="P:L-threonine catabolic process to propionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="324"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN58070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="399" mass="43258" checksum="DFADF63587207A0C" modified="2016-09-07" version="1">MYIENVKKARENIKDVIVKTPILHSKIFSDLCNNIVYMKCENLQLTGAYKLRGALNKIKGLTDYEKSQGVVCSSAGNHAQGVAYASSLIGVDATIVMPKTTPYLKVQSTKNYGGNVVLEGTCYDDAYNEAKRIEAKENKVFIHPFNDIDIIYGQGTIALEILEDIPNIDCIICPIGGGGLISGISLVAKEINPSIKIIGVQSEGAAAMANSFKNKRLTPLTTVNTIADGIAVKTPGDKTFEIIKEHVDEIITVSDAEIVDAFLLLTEKHKLIAEASGVVSLAALKKLNFTGKRVCSVISGGNIDMLTISTLINNGLVSGGRLFCFSTEVPNTPGQLLKLSQLLVKENANIVSLDHDKFKAINRINNVLVEITVETNGDSHIERIVNALENEGYSIRVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y5Q4</accession>
    <name>A0A173Y5Q4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205624.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58028">
        <property type="protein sequence ID" value="CUN58028"/>
        <property type="gene ID" value="ERS852471_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="140"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="319" mass="36377" checksum="91045D5B7FAD07BD" modified="2016-09-07" version="1">MKKIILPLFLLLIFFITLSYDSIRFYFNITKEIINLNSNLAVIASNFYTEPTSEVSYKDVVYKSRGNLDLTLDIYSPKKTNKGASPVIIYVFGDSWMYGNKNLPSELSPIIEILRNEGFTIISTSYELLKTDAIFDKQISDIKDTIRWIYKNKDIYNFDTDNIGIVSPSAGSQLSMIAAFSDNNMFIDDLSLASYPSNISYVVDLFGPTELSKINISLAPTEVAEKFDTYDIENISELYSPINYVKEDLPNTLIIHSIVDTIVPYSSSLKLFNESKNNNNNFELLSLETCTHYLENLSTKEAITLYFKILSFIYKNSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y996</accession>
    <name>A0A173Y996_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoVS</name>
        <name evidence="1" type="ORF">ERS852471_00204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN59298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118697.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59298">
        <property type="protein sequence ID" value="CUN59298"/>
        <property type="gene ID" value="ERS852471_00204"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1985350at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007347">
        <property type="entry name" value="SpoVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35331">
        <property type="entry name" value="PTHR35331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04232">
        <property type="entry name" value="SpoVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN59298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="86" mass="8982" checksum="2813E0D7B30186CC" modified="2016-09-07" version="1">MEVLKVSTKSNPNSVAGALAAIIKEKNIVEIQAVGAGAINQAIKAIAIARGFVAPSGRDIVCVPAFTDIEIDGEERTAIKLIVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNV3</accession>
    <name>A0A173YNV3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">alaS_1</name>
        <name evidence="11" type="synonym">alaS</name>
        <name evidence="13" type="ORF">ERS852471_00269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263163.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64745">
        <property type="protein sequence ID" value="CUN64745"/>
        <property type="gene ID" value="ERS852471_00269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN64745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="882" mass="97745" checksum="F0461C141DDBE59C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRV4</accession>
    <name>A0A173YRV4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sporulation sigma-E factor-processing peptidase</fullName>
            <ecNumber evidence="1">3.4.23.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Membrane-associated aspartic protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Stage II sporulation protein GA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIGA</name>
        <name evidence="4" type="ORF">ERS852471_00284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN65538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263189.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65538">
        <property type="protein sequence ID" value="CUN65538"/>
        <property type="gene ID" value="ERS852471_00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005081">
        <property type="entry name" value="SpoIIGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03419">
        <property type="entry name" value="Peptidase_U4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018571">
        <property type="entry name" value="SpoIIGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018571-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN65538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="267" mass="30865" checksum="DDB4DBF843EEF0BD" modified="2016-09-07" version="1">MEIYVDVIVVENFIINLFLLLITTKLLKYQYRNINIYLAAIIGAIYTLVLFIDIKMLSSLVFKILVAMLMIAMVIRPRRITNIIKGTIVFFINSFMLCGLCFGLVMMQNTYVLGEGFSINNYSIKWILLSIMVFYIVLVRINDYLKDRATINNFIYDIYINIGGNILILKAFLDTGNELREVVSNLPCIIIEDRYLKEIDIKENDKYIINYNTITECGQLEGIKGDKIMIRNSLNDEWQRIDAIICKSPMVLSKDNDYQALLSRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWE6</accession>
    <name>A0A173YWE6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68522">
        <property type="protein sequence ID" value="CUN68522"/>
        <property type="gene ID" value="ERS852471_00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="30" mass="3463" checksum="1BC2EE27433D5834" modified="2016-09-07" version="1">MKKKTREKLVYIISIFMLVAFILGLLPALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0Q2</accession>
    <name>A0A173Z0Q2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dxr</name>
        <name evidence="11" type="ORF">ERS852471_00360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263326.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69844">
        <property type="protein sequence ID" value="CUN69844"/>
        <property type="gene ID" value="ERS852471_00360"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="261"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="386" mass="42886" checksum="E88FFFD46A18B18D" modified="2016-09-07" version="1">MKNISILGATGSIGTQTLDVIRNSTNKINLIGITANSSVKKVIEIIKEFSPKYVAMMDKDCAKEIQNYCSSNDLDIKVLEGIEGLIEIASLDEIDTVVTSVVGMIGLRPTMAAIEAGKDIALANKETLVVAGELVMDKAREMGVKILPVDSEHSAIFQSLSGYTSKDINKIILTASGGPFRGKKIEELKNVTVHEALKHPKWNMGKKISIDSATLMNKGLEVIEAHFLFDCDYDNIEVVVHPQSIIHSMVEYKDASIIAQLGSPDMRLPIQYALNYPERIERIAKPISFYEIATLTFEKPDLHTFKCLELAYKAGKEGGLATTILNGANEEAVALLLEEKIKFLQIAEIIEESLEHFKDEKNNELTLDNIIDLDCRVRKYIRNKWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z208</accession>
    <name>A0A173Z208_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cdsA</name>
        <name evidence="14" type="ORF">ERS852471_00359</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263324.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69753">
        <property type="protein sequence ID" value="CUN69753"/>
        <property type="gene ID" value="ERS852471_00359"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN69753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="29086" checksum="D978947F3E30B29C" modified="2016-09-07" version="1">MKSNSRYLGALILAPLLIFVFLGGMPLKLFTIVISAVGLYEFYNALKSKEIKTLPIIGYILLAIYYLINNNFENMLYILIFITVIALIIPVIDLKYSFMDVAVTILGFIYVGILFSFLPIINNKVGGQYLIWLVFIGSWLCDTLAYYSGKYLGKKKLCPKVSPKKTIAGALGGFLGSVIGCGIFGMIIGKYVPGVDLIHYFLIGALCGIMGQFGDLVASSVKRAVGIKDYGNIIPGHGGILDRFDSILFNGMVVFYYLTFIVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z2C8</accession>
    <name>A0A173Z2C8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dprA</name>
        <name evidence="2" type="ORF">ERS852471_00351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263309.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69238">
        <property type="protein sequence ID" value="CUN69238"/>
        <property type="gene ID" value="ERS852471_00351"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="351" mass="39832" checksum="7BC2DD743FAC9829" modified="2016-09-07" version="1">MREYELWFIVANISNETKIELIKKYNNEENIYNNIDSIDNCYIYKGSEYTKLKSTSLSQGTELFQYINKNNISYVTINSDQYPESLKEINEPPYVLFYKGNLSLLNYNMVAIVGSRKNTTYGEAVTRQIVGELRNIDYGVVSGVAYGIDTIAHKECLDRGIKTIGVLGCGIDIVYPKVNKMVYKEIEKNGLLISEFLPMTKPMPYNFPRRNRIITALSKGVIVVEATVKSGSLITVNYALQYGRDVMAVPGPVLNSNSKGCNLLIRDGAKVFVELDDLYCFLNVIKKDGKNIEKNTIKLLLSDVISSEPIHLDKIIECVNIDRVALFELLFEMQNRNELICLPGNYYARIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z548</accession>
    <name>A0A173Z548_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC</name>
        <name evidence="8" type="ORF">ERS852471_00379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263362.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70860">
        <property type="protein sequence ID" value="CUN70860"/>
        <property type="gene ID" value="ERS852471_00379"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN70860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="447" mass="49489" checksum="F1131D6A8700C3A4" modified="2016-09-07" version="1">MIRKVLIANRGEIAVRVIRACKEMGIKTVAIYSEADKEAMHTQLADESICVGTPKSKDSYLNESNIISAAVITKCNAIHPGFGFLSEKAEFAAICEECNIKFIGPSSEVINLMGNKSKAREIMSKAGVPIVPGSDGLVKSFKEAKIEAKRIGYPVMIKASAGGGGKGIRIVHKEDELENSFFTAKSEAQINFGDDSVYMEKFIENPRHIEFQILADSFGNVVHLGERDCSVQRRNQKLLEEAPSSILSDELREKMGRAAVDAAKAVGYTNAGTIEFLVDKHKNFYFMEMNTRIQVEHPVTEMVTSVDIVKEQLRIANGEKLSINQEDINVKGHSIECRINAENPNKNFAPSPGKIEFLNVPGGNGIRVDTAVYPGYTIPPVYDSMIAKVIVHGNNREEAINKMIRALDEFVIQGVECNIDFQIDILNNERFKLGIFDTSFISTEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z620</accession>
    <name>A0A173Z620_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263391.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71832">
        <property type="protein sequence ID" value="CUN71832"/>
        <property type="gene ID" value="ERS852471_00397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="79" mass="8517" checksum="9B5A470C3CCCB8EB" modified="2016-09-07" version="1">MSRSCCNNNSCNSCNGNSALDFGNSWIAVLAIFLIFGGGGFSQSSFWGDYNKVFRCSGFANAWCDNNNSNFSSLTESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6D1</accession>
    <name>A0A173Z6D1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diamine acetyltransferase 1</fullName>
            <ecNumber evidence="2">2.3.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.57" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263375.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71353">
        <property type="protein sequence ID" value="CUN71353"/>
        <property type="gene ID" value="ERS852471_00388"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="19210" checksum="3852E04BBB9FACBC" modified="2016-09-07" version="1">MRRYNTNIEGFTLRETSENDLSLILGFIKEIAEYEKLSHAVDATEESLKKYVFEKRRAEVLIVEKDENPIGYVVYFYNFSTFTGTSGLYLEDVFIRSEYRGMGLGKEIFKILGKLAREEGCKRMEWVCLNWNEPSKKFYKGLGAISMDEWTTFRLTEDYIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8J6</accession>
    <name>A0A173Z8J6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpS2</name>
        <name evidence="8" type="synonym">trpS</name>
        <name evidence="10" type="ORF">ERS852471_00413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263417.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72564">
        <property type="protein sequence ID" value="CUN72564"/>
        <property type="gene ID" value="ERS852471_00413"/>
    </dbReference>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN72564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="337" mass="38050" checksum="C93C297458755CA2" modified="2016-09-07" version="1">MNKEIILTGDRPTGKLHLGHYIGSLKNRVKLQNTGKYESFIMIADQQALTDNARNPEKIRNSLIEVALDYLAVGIEPSKATIFVQSQIQELNELTMHYLNLVTVARLNRNPTVKEEIKLRDFKNSIPAGFLIYPVSQAADITAFKANLVPVGEDQLPMIEQTREIVRTFNSIYGDILVEPKAMVPEDTLGRLPGIDGKAKMSKSLGNAIYISDEADVVSKKIMSMYTDPNHIKVSDPGKVEGNTVFTYLDAFCKDKEAVCSMKEHYKQGGLGDVKVKRYLNEVLQAELEPIRKRRSEYEKDLDYVYKILREGSIKAREVASKTTKEVREAIGIEYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZIG4</accession>
    <name>A0A173ZIG4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263541.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76202">
        <property type="protein sequence ID" value="CUN76202"/>
        <property type="gene ID" value="ERS852471_00482"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938730at2"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="3">
        <location>
            <begin position="66"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="32830" checksum="91F2D8E3FF8BE03C" modified="2016-09-07" version="1">MNRLHKEIYLKKYPYVEEYIDRNNIDFEELEKVYDDFVKYQSSYETQADFIANILRSNENIHSVKSRIKNPERLIEKIIRKTEDRKVKNGKDFYFNVDNYKNEITDLIGIRVLHIFKDQWKDIHDFIVNTWKVIEITANIRDGDDRLIFDDLGIEVRSRQSGYRSVHYLVECYPTNQKVIAEIQVRTIFEEGYGEIDHRLRYSHHEIPEILKSNLLLFNRIVGSADEMASLINMLNNNLGDKENYYENKLREKDEEIQRLNEELEKYKTRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZLL0</accession>
    <name>A0A173ZLL0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ycaM</name>
        <name evidence="6" type="ORF">ERS852471_00480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN76108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263537.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76108">
        <property type="protein sequence ID" value="CUN76108"/>
        <property type="gene ID" value="ERS852471_00480"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
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            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN76108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="475" mass="52826" checksum="77ECD742B181AFBF" modified="2016-09-07" version="1">MTENNNKKIMWYSLALMAFSGVWGFGNVINGFSEYNGLQAIVAWIIIFAIYFVPYALMVGELGSAFKNHGGGVSSWVGETINPKIAYFAGWTYWIVHMPYLSQKPNSFMIASSWAIFQDGRISQMNPVLLQVSCLIVFIVALYIAGKGINPLKKLSALAGSSMFIMSMLFILLMLAAPAITNVQLNQIDWSWSTFMPKFDGAFFTSLSILVFAVGGCEKISPYVNQMKDPAKGFSRGMIALAVMVAVTAILGTISLGLMIDSNNIPKDLMTNGAYYAFQKLGEYYKLGNLFVILYAITNMIGQFAVLIISIDAPLRMLLNSGDRKYIPEKLFAKNENGAYVNGHKLIFVIVSILIIVPAMGIGSVDELVRWLVKLNAVCMPLRYLWVFVAYIALKKAGDKFEREYYFVKNKTLGIIIGIWCFAFTAFACIGGMYSEDKFQLILNIVTPFILILLGFILPQFAKKNKNTNSLKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZXU4</accession>
    <name>A0A173ZXU4_9CLOT</name>
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        <recommendedName>
            <fullName evidence="1">UPF0371 protein ERS852471_00511</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0371 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263615.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80449">
        <property type="protein sequence ID" value="CUN80449"/>
        <property type="gene ID" value="ERS852471_00511"/>
    </dbReference>
    <dbReference type="OrthoDB" id="528480at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01567">
        <property type="entry name" value="UPF0371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014999">
        <property type="entry name" value="UPF0371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08903">
        <property type="entry name" value="DUF1846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033132">
        <property type="entry name" value="DUF1846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="502" mass="56827" checksum="B76D88887A193EC3" modified="2016-09-07" version="1">MKIGFDHEKYLEEQSKFILERVNNYDKLYLEFGGKLLFDLHAKRVLPGFDENAKIKLLHKLRENVEVVICVYAGDIERNKIRGDFGITYDMDVMRLIDDLRSYDLEVNSVVITRYNDQPSATVFINKLERRGIKVYKHRATKGYPTDVDTIVSDEGYGKNPYIETSKPIVVVTAPGPGSGKLATCLSQLYHEYKRGNSAGYSKFETFPVWNVPLKHPLNIAYEAATVDLKDVNMIDYFHLEAYGETAVNYNRDLESFPVLRRIIEKITGKESVYKSPTDMGVNRVGFGIVDDEVVREASKQEIIRRYFKTGCEYKKGYVDKETFEAAKLIMEQVNLKEEDRNVVAPARKRAEELKEKSNKNEICPVIALELQDGTIITGRNTEVLDDAAAVLLNAIKHLANISDDIHLISPVILEPIIKLKSQTLANKNVSLNCEEVLIALSICAATNPTAQVAMEKLPMLKNCQAHSTTILPTSDEQTFRKLGIDITCDAVYPSESLYYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AAV3</accession>
    <name>A0A174AAV3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phoR_3</name>
        <name evidence="10" type="ORF">ERS852471_00571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263719.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84900">
        <property type="protein sequence ID" value="CUN84900"/>
        <property type="gene ID" value="ERS852471_00571"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017554" description="Histidine kinase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="853"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122449" checksum="A02887191E707EDE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AH52</accession>
    <name>A0A174AH52_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase ArsC</fullName>
            <ecNumber evidence="2">1.20.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsC</name>
        <name evidence="2" type="ORF">ERS852471_00606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263787.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87523">
        <property type="protein sequence ID" value="CUN87523"/>
        <property type="gene ID" value="ERS852471_00606"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="135" mass="15133" checksum="E245DBD60142BCE9" modified="2016-09-07" version="1">MSKPKVAFICVHNSCRSQMAEALGKLFGSEVFESYSAGTEIKPQINQDAVRIIEDLYNVNMNKTQKSKLLSDIPEIDIAIKMGCNVVCPYLKAKHTEDWGLEDPTGKSDEEFIKIAKTIEAKVKDLAERIKNNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AH86</accession>
    <name>A0A174AH86_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263795.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87764">
        <property type="protein sequence ID" value="CUN87764"/>
        <property type="gene ID" value="ERS852471_00610"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1518604at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="19419" checksum="3B36380AFD37A401" modified="2016-09-07" version="1">MKILLAILLGGFFGFALAYVGATGFKNILKMLRLEDLSLAKIILFAIGFSSALLSLTAMLGIFDVSHLSIKTMNLGVIIGGLIFGIAFGSIGTCPGTCIGSIGSKGVKKAISAVIGGLVGAFAFTMSYGPLKNIGLFDMLNLGKLTLFNISDKYPSVFNTGYLGLLLVGIIFMIGAYLLPKHILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIT4</accession>
    <name>A0A174AIT4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system beta-glucoside-specific EIIBCA component BglP</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">bglP1</name>
        <name evidence="16" type="ORF">ERS852471_00618</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN88307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263810.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88307">
        <property type="protein sequence ID" value="CUN88307"/>
        <property type="gene ID" value="ERS852471_00618"/>
    </dbReference>
    <dbReference type="OrthoDB" id="328780at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011297">
        <property type="entry name" value="PTS_IIABC_b_glu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01995">
        <property type="entry name" value="PTS-II-ABC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="102"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="490"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN88307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="620" mass="66331" checksum="AC6A53A8D6B8AA4D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKW8</accession>
    <name>A0A174AKW8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynR_2</name>
        <name evidence="3" type="ORF">ERS852471_00631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263836.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89047">
        <property type="protein sequence ID" value="CUN89047"/>
        <property type="gene ID" value="ERS852471_00631"/>
    </dbReference>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="293" mass="33382" checksum="34A3FF7DDB24A93B" modified="2016-09-07" version="1">MIGKLDLYRVFRQVGKSGSFSKAAEELYMTQPAVSQSIMQLESELNIRLFNRTRKGVTFTTEGENLFDYVNSAITLIEAGEEKIFEFKNLSTGELKIGVGDTISKHYLISFLEKFHNKYPNIKLRIINSTTTELCSYIKSGDIDIAICNFPIDDSSLELIPCAEIQDIFVCGEKYKKLISDKVSYEELTKLPLIFLEKSSNSRKYVESFMNSKGVNLSPDFELGSYDLLLEFAKINLGIACVIKEFSEEYLEKNYLYEIDTIEKIPKRSIGACYLKKVPLSLGAIEFLKIMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMD5</accession>
    <name>A0A174AMD5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fccA_1</name>
        <name evidence="6" type="ORF">ERS852471_00642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89577">
        <property type="protein sequence ID" value="CUN89577"/>
        <property type="gene ID" value="ERS852471_00642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017784" evidence="4">
        <location>
            <begin position="40"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN89577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="633" mass="66283" checksum="6A50DBE79AD9311B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AUW3</accession>
    <name>A0A174AUW3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hybrid cluster protein-associated redox disulfide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263886.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91276">
        <property type="protein sequence ID" value="CUN91276"/>
        <property type="gene ID" value="ERS852471_00663"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1961381at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN91276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="61" mass="6611" checksum="EE6AB40163DF8E68" modified="2016-09-07" version="1">MINKDMTIGEILDINFKAADVLMGFGMGCLGCPSARVESLEQACSIHGLNLEEVLEKLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5D3</accession>
    <name>A0A174B5D3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263988.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95613">
        <property type="protein sequence ID" value="CUN95613"/>
        <property type="gene ID" value="ERS852471_00708"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="323" mass="37396" checksum="19BD9D7B01992F02" modified="2016-09-07" version="1">MKIKDDIYGDFEIEGVLEELINTKEFQRLKNIHQGGASYLVNPNWNVTRYEHSVGTMLLIKKMNGTIEEQIAGLLHDISHTAFSHVVDFALNKSNEDYHEEIYEKIIENSGIPEILIKHGYDYKDILYNEKKWTILERSAPDLCADRIDYTLRDMYSYGYISLVAIKNFLESLQVIDGEIIITTINAAEWFVNTYYKEVIGFFLNPLNIYAYNRLSNALKVALDNDIITLEDLLQDDNYVLNILKNSKNQEIRSLIQSLNYNVDVIENKEEYDIHQVNKLRIIDPTVIIDGVISKSSEKSPLIKILTQQALQKSREGVFVKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBF0</accession>
    <name>A0A174BBF0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264067.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98097">
        <property type="protein sequence ID" value="CUN98097"/>
        <property type="gene ID" value="ERS852471_00753"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1974782at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN98097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="132" mass="15582" checksum="8320C399115C69A2" modified="2016-09-07" version="1">MDYSSLILMERDAETGFVTKELGSYQVSVEAEYVKGFYVKGDTVYIKFDTNKDVEEWEYSAIYDVFNYSIFEEEGFKIEDVDDEYNPTFLITFKYEDEHQYISEKLSLALGLIHEAMEKAFNDIEGKEEEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBH6</accession>
    <name>A0A174BBH6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase T</fullName>
            <ecNumber evidence="7">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aminotripeptidase</fullName>
            <shortName evidence="7">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pepT</name>
        <name evidence="11" type="ORF">ERS852471_00732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264024.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97018">
        <property type="protein sequence ID" value="CUN97018"/>
        <property type="gene ID" value="ERS852471_00732"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="10">
        <location>
            <begin position="205"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN97018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="405" mass="45192" checksum="93F589AE4EA662DA" modified="2016-09-07" version="1">MKKVDERFLEYVKVDTKSDTTTGTTPSTKGQLVLADILAKELKEMGLNDVTISEYGYVYATLEKNCNKEIPTIGFIAHMDTAPDYSGKDVNPQIVKNYDGGDIKLNEDTILSPKFSPELKNYIGKTLITTDGNTLLGADDKAGIAEIMTAVEYLINHPEIEHGDIKIGFTPDEEIGEGADHFDVKYFGADFAYTIDGGAIGELEYENFNAAGVKVTIKGVNVHPGYAKNKMVNSITIANEFASMLPVDEVPEKTSGYEGFYHLIELNGTVENTSMQYIIRDFFNDTFVKRQERLKEIEKDLNQKYGEGTVTVDIKEQYRNMKEMVEPVIHIVDNAKRAMEEAEVTPEIRPIRGGTDGSRLSYMGLPTPNMFTGGENFHGKYEYIAIESMEKAVEVIVNIVKNYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BF97</accession>
    <name>A0A174BF97_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UV damage endonuclease</fullName>
            <ecNumber evidence="7">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">uvsE</name>
        <name evidence="7" type="ORF">ERS852471_00757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264075.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98326">
        <property type="protein sequence ID" value="CUN98326"/>
        <property type="gene ID" value="ERS852471_00757"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1036440at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="PTHR31290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN98326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="412" mass="48605" checksum="B0375FA7BA87BB10" modified="2016-09-07" version="1">MKIGYACTPLMVPYKTTRKLTLSNYSEEKVSLLIKENLEDLYSILYYNNSKNINFFRISSDVIPLGSHPINNYNWWDNNKNLLDKIGSYIKTNNIRVSMHPGQYTLLNSPKKEVVEKSICDLKFHCKFLDSLNLPSSHKIVLHVGGVYGNKKSAIERFITEYNNLDNNIKKRLIIENDERFFSIYDLLEIYTKCKVPIVFDNLHYECYGDTSMSISELLPLIQRTWKKDDGDMKVHYSIQDITKKSGAHSPTIFIDNFLAYINNYDFSNIDIMLEVKDKEVSAIKAINSINYLNNNFSYIDYLNEIQAYQLFVLEKYDYSGISKLKDIKPQNNFLKLYTFIDSLIYEEYNEVSFRRALNQGFESIRKDLNSKEINHYNKNYKDQSYSKCKEYLKKLSDKYNLPLNNTYYFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFV2</accession>
    <name>A0A174BFV2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein A, PspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydjF</name>
        <name evidence="3" type="ORF">ERS852471_00787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264131.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99911">
        <property type="protein sequence ID" value="CUN99911"/>
        <property type="gene ID" value="ERS852471_00787"/>
    </dbReference>
    <dbReference type="OrthoDB" id="941029at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN99911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="26647" checksum="17C10F8D8D365B2F" modified="2016-09-07" version="1">MSILKRFTDIMSSNINAMLDKCEDPVKMVDQLMRNLNKDLNEIKVETASVMAEENRAKRELDECQEQVNKMLDYAKRAVAAGNDDDARRFLDKKVTLSEKLTLLQTKYDSAKANSEKMRSMYNKVSNQIEELNERRAVIKAKMTTAKIQEKVNTLGNSVNKSTANMDSFARMEEKANRMLDEANAMAELNSKPVDDIDDLMSKYNSNNSAVEDELAALKGNNDAVEDMLRELKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGH9</accession>
    <name>A0A174BGH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00132">
        <property type="protein sequence ID" value="CUO00132"/>
        <property type="gene ID" value="ERS852471_00791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="36480" checksum="01D70B522703BA34" modified="2016-09-07" version="1">MFFLLKSIGFIIILLTKSFFYILLFTYKAIIFAFKAIIFLFKNKFLRVPTILLILGIVFDLNFSILSSIYFIYLMHIVALHNGIYHNIHSNIMRFFKELKENDNIKDILKLLPSNNIVLSNLSLENDDRTLNIYHLAITPNGLYNIIPLSNFLDNNSSKDIANKLIYDIYNETENIKNLLVDIIEEDVPLTTLILSPENDFDNTINIDTFKLIQENQLLFMINSNKDNGNYLDIDTIKDLILDNKAWFLDKIWFKFVYFINNNRKILSFFMLCPIIYCIYMIILTIFYSGITIMIDDIIKFLSNIINIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJR2</accession>
    <name>A0A174BJR2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phoR_5</name>
        <name evidence="7" type="ORF">ERS852471_00806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00974">
        <property type="protein sequence ID" value="CUO00974"/>
        <property type="gene ID" value="ERS852471_00806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="510"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO00974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="724" mass="82456" checksum="B620BBB5EB7AB66E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BK24</accession>
    <name>A0A174BK24_9CLOT</name>
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        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mngR_1</name>
        <name evidence="2" type="ORF">ERS852471_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264189.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01362">
        <property type="protein sequence ID" value="CUO01362"/>
        <property type="gene ID" value="ERS852471_00814"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO01362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="26254" checksum="3CA9DCDFBBC6A00A" modified="2016-09-07" version="1">MKSKDILKDLIESIVCGELEVNSKFPSESNLAQKYECNRHTIRKVMDVLIERGYARKSHGGPTFVNELPCTYSLNLSSQYDLYSAKDIHTKVLNLKQIVADDNICEKLQIDKGSKVWYITRLRCINTKIDHIEYIYMPISLFPNLTKQNCEASLLSYIEYDNDYEISHGIKNISAVILTNEEMELSNKQDSNLAIQVENIGYLTNGRVYEYSINKHFNNSIVYYAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKY5</accession>
    <name>A0A174BKY5_9CLOT</name>
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        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
            <ecNumber evidence="3">1.8.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdr</name>
        <name evidence="3" type="ORF">ERS852471_00820</name>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="CUO01672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264201.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01672">
        <property type="protein sequence ID" value="CUO01672"/>
        <property type="gene ID" value="ERS852471_00820"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050451">
        <property type="term" value="F:CoA-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
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    </dbReference>
    <dbReference type="Pfam" id="PF07992">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="464"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="566" mass="62435" checksum="557FB157839B83EA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BLD0</accession>
    <name>A0A174BLD0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS system sorbose-specific transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">agaC</name>
        <name evidence="8" type="ORF">ERS852471_00825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264209.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01881">
        <property type="protein sequence ID" value="CUO01881"/>
        <property type="gene ID" value="ERS852471_00825"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO01881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="271" mass="28019" checksum="A9D79CD0D4BA064E" modified="2016-09-07" version="1">MDFNVVQILLVAVFAFIAGIDQFSFLESLYQPIVSGAVVGAILGDLQTGLIVGGTYQLMTIGNMPIGGAQPPNAVIGGIMAVVFAISSKLDPAAAVGLAVPFALIGQYCVTLLFTIMSPLMSKADKYAEDANTKGIENLNYLAMGALGLFFALVVVIGLIGGAAAGKTLTALSEQFAWFMSGLSAAGGMMRYVGFAILLRIMLSNDLWGIYFAGFALATIIGKIDGLSGSALLIIAFIGIAVAIYDFQTNVKMKSSAAYAPVGGGDDEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BN78</accession>
    <name>A0A174BN78_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM dependent methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264180.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01145">
        <property type="protein sequence ID" value="CUO01145"/>
        <property type="gene ID" value="ERS852471_00809"/>
    </dbReference>
    <dbReference type="OrthoDB" id="880894at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="153"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="387" mass="45181" checksum="838B021F993811D2" modified="2016-09-07" version="1">MNDLRKAICDMVSENIVKVVISNKMKSDVQYNKIVFLLKEKKGREYYQIERYTDKQVFHENIDKEKLEESLFENIESRYKQVNAWSENSTFDMKISKKGKVFLGKKSADNKKVANKSHNKEKNYILKEGMLIQPLIDLGVFTKEGKVVNSKYDKYKQINRFVEIIDDEIKKIDQKELTILDFGCGKSYLTFVLYYYFVEIKKINVKMIGLDLKEDVIKKCNDIAKRYNYENLHFEIGDINGFKYNNKVDMVITLHACDTATDYALYNAVKWNAKMIFSVPCCQHEFNAQMKTEELSILTRYGIVQERIAALMTDSVRANILEALGYKTQLLEFIDIAHSPKNILIRASKGNISMEKKEKVLVEVENLMKQFNLSPTLYNLLKNDNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7I7</accession>
    <name>A0A174C7I7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiD_1</name>
        <name evidence="7" type="ORF">ERS852471_00931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08923">
        <property type="protein sequence ID" value="CUO08923"/>
        <property type="gene ID" value="ERS852471_00931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO08923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="32990" checksum="9EC95EE610209270" modified="2016-09-07" version="1">MNSTASVNKIKTFEKEGTFLTSLKEFFQVIWRNKMARVGFLILVFFLLLAIFGPMVVPAPESNYLARLKPPSAAHLLGTDYAGRDILALFINGSRSVLLVAFYAALFSIVFACGIGITAGLVGGKVDEILMLITNIVLTMPTLPVTMVLSMVINVSNDILFGLVLSLWSWAGLAKAIRSQVLVIRNKDFIEASRVMGISTINIIIKDVVPNITSFIAINFIAIMKGAIMTSVSLMVLGLVPFKGSHWGMMIQMAMSQSAVLYGGLGPIVYFMTPIMGIVLFQLGCYFFANGLDEAMNPRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7M2</accession>
    <name>A0A174C7M2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphotransferase system cellobiose-specific component IIB</fullName>
            <ecNumber evidence="6">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">chbB_2</name>
        <name evidence="6" type="ORF">ERS852471_00911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264385.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07885">
        <property type="protein sequence ID" value="CUO07885"/>
        <property type="gene ID" value="ERS852471_00911"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846001at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018982" evidence="4">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="107" mass="12116" checksum="BD8FC0B859D68309" modified="2016-09-07" version="1">MKKFYLFCSAGMSTSLLASKMQKAADAHKLPIEVKAFPIGTMGDIIEKYNPDCILLGPQVKYLLDDTKQRYGHLNKPIFVIDMQDYGVMDGEKVLKTAIMHYKKQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHA4</accession>
    <name>A0A174CHA4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uidA</name>
        <name evidence="9" type="ORF">ERS852471_00976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205652.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11168">
        <property type="protein sequence ID" value="CUO11168"/>
        <property type="gene ID" value="ERS852471_00976"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="8">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="191"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="7">
        <location>
            <begin position="302"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO11168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="604" mass="71082" checksum="FFEB6874C1737601" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CSX5</accession>
    <name>A0A174CSX5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">immR_1</name>
        <name evidence="3" type="ORF">ERS852471_01022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264559.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14908">
        <property type="protein sequence ID" value="CUO14908"/>
        <property type="gene ID" value="ERS852471_01022"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="22201" checksum="B7EFCBDCB22F19F2" modified="2016-09-07" version="1">MEIGKQIKKYRSEMKLSQDELAEKIFVSRQTISNWENNKSYPDVKSLLLLSSLFNVSLDILIKGDLEEMKEKIKTEDIDGFKHDSNIFSILLLSTILLPVPLLRFMGYVGAGIWGLIAIGAIYYAIRVEKYKKNFNIQTYREILAFFEGKDMNELEKNQEYGKRPYQKFLLAIGAGLLTILVAVIMRYILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CY36</accession>
    <name>A0A174CY36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tdh</name>
        <name evidence="3" type="ORF">ERS852471_01058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.103" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO16710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16710">
        <property type="protein sequence ID" value="CUO16710"/>
        <property type="gene ID" value="ERS852471_01058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="167"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO16710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="340" mass="37408" checksum="FB17753FC232CCDB" modified="2016-09-07" version="1">MENNMKAAIYMGKGNIEIQDLPLEKPGDYDVLIQNIYSSICGTDVAVYNHGPNTGHRITVGEEFGHETISRIVAIGEKVSDFKVGERVYPYPRYAKGNTKRAGTIGGFSEYILIPNAKRNISLYPVDDTISDKIACLIEPFTVGCRAARRGQLKQGQKAVVFGCGTIGLSAAIALKYFGIDKVMVCDVSDFRLKIAKNMGFYTCNTQNENFNETAKKYFGEASSLNGTVADIDCFIDAAGSEDILNLFMEYGKIESKFVSVAVNNALQSIDLLHLTFSQKSIIGSGGYMPEDVKDVMQIMKSGQWNIESMITHEFSLDKIEQAIQTAGDTKNSLNVVIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZI0</accession>
    <name>A0A174CZI0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PTS system, fructose-specific component family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">fruA</name>
        <name evidence="17" type="ORF">ERS852471_01101</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264621.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18921">
        <property type="protein sequence ID" value="CUO18921"/>
        <property type="gene ID" value="ERS852471_01101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1810962at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="14">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="15">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="16">
        <location>
            <begin position="296"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO18921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="629" mass="66061" checksum="1FFACFE3A12FCA84" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4U3</accession>
    <name>A0A174D4U3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264654.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20554">
        <property type="protein sequence ID" value="CUO20554"/>
        <property type="gene ID" value="ERS852471_01135"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="273" mass="30838" checksum="33C4037E46A69765" modified="2016-09-07" version="1">MSKEKNKIPSISIILIIISFFIMTVSKAVGIVLITAIILFNILKQKYLINVIKGNRAYTAKDYATAIEEYKKAVSSKYANAGIIRGYILIELKHGNPDRAKEVLDKLLAERKFKDHEMLNLNVSKALILWKTGNLEVAINKLKDLLSKEKSSYIYETLTSLLLIAGRVEESLELLKEGLEYDDSNNILKSNFGEANFKLGNTEVAEETFASLLEENILFIEPYYFYALILKQKGETEKAIELLEKALDTNDSLLTTVSKDSAEKVLYELTPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7W7</accession>
    <name>A0A174D7W7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpmI</name>
        <name evidence="7" type="ORF">ERS852471_01126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264645.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20150">
        <property type="protein sequence ID" value="CUO20150"/>
        <property type="gene ID" value="ERS852471_01126"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO20150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="65" mass="7503" checksum="6F6172041F439CBB" modified="2016-09-07" version="1">MPKMKTHKGAAKRFRKTGTGKLKRAKAFKSHILTKKSAKRKRNLRKASYVSTTQEKAMKKLLPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQS3</accession>
    <name>A0A174DQS3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-amino-4-deoxychorismate lyase</fullName>
            <ecNumber evidence="6">2.6.1.42</ecNumber>
            <ecNumber evidence="6">4.1.3.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ilvE_2</name>
        <name evidence="6" type="ORF">ERS852471_01235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="6"/>
    <dbReference type="EC" id="4.1.3.38" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264757.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26598">
        <property type="protein sequence ID" value="CUO26598"/>
        <property type="gene ID" value="ERS852471_01235"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO26598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="250" mass="28989" checksum="A0C657C543826FFC" modified="2016-09-07" version="1">MRKIIFNDDKALIDTGIFFGRGVFETILLKGKPHFLNEHIERLNDGITKLSLGGHITSDMVLEKINEYKLDNLALKIVVTEKNIIFSTREIKYKAENYEQGFKVKLSNNIRNSKSCLTYIKSINYLDNLLEYEKAQKEEYNEVLFLNENNKLSEGSTTNVFIVKDNKIYTPSEKCGLLSGIIRKYVIDNFKVYEKEISKEELLNADEVFLTNSLVGVIKVSEIEGCKFRNRVTEKVRKAYEEYIGIREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSH9</accession>
    <name>A0A174DSH9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">glsA</name>
        <name evidence="6" type="ORF">ERS852471_01245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264775.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27066">
        <property type="protein sequence ID" value="CUO27066"/>
        <property type="gene ID" value="ERS852471_01245"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1288854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO27066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="33657" checksum="67FABEE433E43A63" modified="2016-09-07" version="1">MKNLLVNLVDKNKKYTEEGLVASYIPALLKANKDDLGICVVDIKNNEEYWAGESNVKFTIQSISKVVGLIIALSDNGKDAVFKKVNVEPTGMGFNSIVNLEIRDEKPYNPMINAGAIVTTSLIYGETEERKLERILNFIRRATNNEDININQEIYESEKKTGDRNRSLAYFIKSNGILEGDVEEVLDLYFKQCSIEVTARDLARFGAVIANDGITPWSNEVLMSREVCRIVKTIMVTCGMYDASGEFAVQVGIPAKSGVGGGILASVPRRFGIGIYGPSLDKKGNSIGGIRILKELSEELQLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSL3</accession>
    <name>A0A174DSL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YunB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264831.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28463">
        <property type="protein sequence ID" value="CUO28463"/>
        <property type="gene ID" value="ERS852471_01275"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637742at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014197">
        <property type="entry name" value="Sporulation_prot_YunB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09560">
        <property type="entry name" value="Spore_YunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021383">
        <property type="entry name" value="YunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02832">
        <property type="entry name" value="spo_yunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="24999" checksum="50C81C8CC26E0848" modified="2016-09-07" version="1">MRYYTERPRRGKNRTKVPYMLFVIIAIVIVFNSFLYLFQKRILPTVLDIAEIVMRSEAVKVINEETMRIYEENFNYDDIMKIEKDSDGNITMIRSDTIKQNKLTAEVVLGCNEKLKNLGELGTKIPLGYMTNNAFFYRMGPKITVNMEQIGNINTSYDSTFESAGINQVRHKIYLNVDVKMRLVVPLASKDVELTCEIPVAETIIVGKIPDTAVNIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0Z3</accession>
    <name>A0A174E0Z3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">cobT</name>
        <name evidence="11" type="ORF">ERS852471_01306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264887.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29965">
        <property type="protein sequence ID" value="CUO29965"/>
        <property type="gene ID" value="ERS852471_01306"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO29965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="368" mass="39921" checksum="84ADF62A7B8D047F" modified="2016-09-07" version="1">MNLLDDALSKIKPLDQEIMDKTWEYLDNLSKPLRSLGVLEEIAVKISGMTGEVFNKVNKKNILIFCADNGVCDEGVSGCSQEVTNIVTNNLPNYTTGVGILAKFYGSEIKVIDVGVKGQISNLNVVNKKVREGSRNMALGNALTREEVIKAINIGIESVDILVSEGYNLLGTGEMGIGNTSTSTAVIAALLDLDVEDLVGLGAGLTEGGLENKKKVLRKALELNNPNKDDVIDVLSKVGGLDIASLCGSFIGAAKNRVPIVIDGLISSAAALCAYKINETVKDFMFSSHKSTEKAMNEVYKEMNLEPMFDLKMRLGEGSGCPIAFSIIESALTIIKEMDTFDKAGLDNDESKNYKKLYEERKKYEKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E147</accession>
    <name>A0A174E147_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264961.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31602">
        <property type="protein sequence ID" value="CUO31602"/>
        <property type="gene ID" value="ERS852471_01348"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2005506at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="15634" checksum="060C76FC48CDA633" modified="2016-09-07" version="1">MIILAMLGGILTTLSMIVNSSLGKKIGVLQSTCINYIVGLICSTLVLVVLGNSINVTTETFAKMPFYVFLGGAIGVSVVYLSNIIIPKIPVVYSTLLLFVGQVITGIIIDFFVMSEISFSKLIGAIIIILGILYNSRIDEKKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E405</accession>
    <name>A0A174E405_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264939.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31169">
        <property type="protein sequence ID" value="CUO31169"/>
        <property type="gene ID" value="ERS852471_01336"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034800at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="59" mass="6684" checksum="76CAD77FDCF0CD33" modified="2016-09-07" version="1">MSKMKKINDLTDVQLKSCTSHAKPSKEPNDGYFIEKNPNDSFSCEGTVRYGEEQDVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EE36</accession>
    <name>A0A174EE36_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription-repair-coupling factor</fullName>
            <shortName evidence="9">TRCF</shortName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">mfd</name>
        <name evidence="12" type="ORF">ERS852471_01403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35038">
        <property type="protein sequence ID" value="CUO35038"/>
        <property type="gene ID" value="ERS852471_01403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="637"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="807"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1165" mass="134216" checksum="6A871AEE80348ACA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMF6</accession>
    <name>A0A174EMF6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Channel protein, hemolysin III family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yqfA</name>
        <name evidence="7" type="ORF">ERS852471_01488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265208.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38964">
        <property type="protein sequence ID" value="CUO38964"/>
        <property type="gene ID" value="ERS852471_01488"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1659567at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO38964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="215" mass="23651" checksum="CF29A1340AC78B33" modified="2016-09-07" version="1">MYKKLREPINSITHLSGAVFSFIALFAMLAKAFVTNVSNISIASVTIFGISLILLYTVSGTYHGIISSDKIINFLQKLDHSMIFILIAGSYAPFCLIALGGTLGRNMFLVMISIAIAGIVFKLCWFSAPRWLQTALYIAMGWSAIFVIKPLSAALPPISIFLLVLGGVFYTIGGVIYATKSQKFKIGNFGFHEIFHVFILLGSLTHFICVFTYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EP46</accession>
    <name>A0A174EP46_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265170.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37935">
        <property type="protein sequence ID" value="CUO37935"/>
        <property type="gene ID" value="ERS852471_01468"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1725392at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038728">
        <property type="entry name" value="YkvI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37814">
        <property type="entry name" value="PTHR37814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="353" mass="38824" checksum="7644680C29AB9BF7" modified="2016-09-07" version="1">MKKDLTKIFQIAVVFIGTIVGAGLASGKEITQFFTSYGLSSFIGIICCGIFYIIMGSIICKIGIAYKLNSYTDVLKVISPNLLGKITGIITTVYLLSSASIILAGSGALINQFFGIPKIVGTLIMLGVASIFLLRDTNGLIEVNSFIVPSLITTISVIFILYCLFSNDTLSFEFINSFEPQKSGIVLSTILYAGYNVLCCSGVLVPLSNEVKKPKIMTYGVIFGALGLTVLSCIINLLLFINQPYIYQYEIPLLLVAQRFGNIIQAILLIIIWLEMFSTEVSDVYSISKSLEQTFNIKFKHGIFLVLAVALPISQIGFSNLISILYPLFGILSLIFISQCIYFYIKHKKELNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUA8</accession>
    <name>A0A174EUA8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265266.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41543">
        <property type="protein sequence ID" value="CUO41543"/>
        <property type="gene ID" value="ERS852471_01517"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1201680at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="30133" checksum="E2EAA9E5735BDEBB" modified="2016-09-07" version="1">MSVNIKKLYNDPLYIRNIDNPTEDEQIEAVKRNGMVIKFINNPSNVVKREAILNNPLCIEYIEDLPEELAILAVQLLWNSIKYVKNLTNNIMREAVKSKGWAIQFIENPPEEIKLLAVEKDFDAIKYIKNPSEEVQIRAIETYWGAIRFIDNPTLEARRCAIKIDEESINYIMNYDFDDLKIFIGDNINIVKYVYDSIDIDTILEIIKEKICKDDIDNKYMRDFLELEVLEMDKIDFVKNYGSKNTKMTLIDYKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYD8</accession>
    <name>A0A174EYD8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nupX_1</name>
        <name evidence="9" type="ORF">ERS852471_01506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO41060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265246.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41060">
        <property type="protein sequence ID" value="CUO41060"/>
        <property type="gene ID" value="ERS852471_01506"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437016at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="192"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO41060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="402" mass="41861" checksum="A510DE9EA487BECA" modified="2016-09-07" version="1">MAILNSIVGIVFIFLVAFLLSNNKKKINWRTIIIGFLIQFGFAVAALKWSVGKFVLSKIALGVQSVINYANEGIKFLFGSLNNDGSIFAVNVLGVIIFTSAIVAVLYYLGVMQFVIKIIGGALSKLLGTSKLESLSASGNIFLSQTEAPLLIRPYVEKLTESELFTVMVGGVASVSGSVLVGYSLLGIPIEYLVSASFMAAPAGLIMAKIIIPELKQAKANEQVEMVKDDSANVVDAAAKGAIDGLGLVLNIAAILLAFVALIALINGLIGWIGGFFGIANLSLQSILGYIFAPVATIIGVPMKESITVGSLIGQKIVLNEFVAFTSLSPLMATLSTKAAAIATFSLCGFANISSIAILIGGIGGMAPSRKGDIARLGWKAIIAGTLANLLSATIAGLLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F209</accession>
    <name>A0A174F209_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42225">
        <property type="protein sequence ID" value="CUO42225"/>
        <property type="gene ID" value="ERS852471_01532"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="401" mass="46965" checksum="1E6C5CBD7BBBA10F" modified="2016-09-07" version="1">MTYICIFIIILLLIVNYTIYKMNYIHKNLFITINILIILYSIISVSIYYNNIYLNYDNGILFGNVLNNHFCDEYRYYKDSEILMNHLKSGNFYDWITGILPDYEYIDPQGHPGFGNYNIFVIIISLLRILGFNSVLELILIKLFILLITIIFIYKLSNIFLTEKISLVVTIIYSLLPGYILTNTLLMRDNIIILLCIICIYYILKKDYNLFILIPTLIALFLLRAYLPPILLISYIFCYKNTTKLISFKDIIYLAIIFLSVIFFSSVNFNYTIMRIMQENFQVLFGSGLIAPIKVFINTFIHIAIDPQLLNFLLSGQLYLILYSLGNICSNILSILLIIKLIMLLFSNLNNKTLYLLKFTFYFSFITGILVLSKDGYIINRIALMWIPLFLIILFIPRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9C8</accession>
    <name>A0A174F9C8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YvrJ protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265424.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45416">
        <property type="protein sequence ID" value="CUO45416"/>
        <property type="gene ID" value="ERS852471_01598"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2099215at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024419">
        <property type="entry name" value="YvrJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12841">
        <property type="entry name" value="YvrJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7180" checksum="DEB076413BDC6396" modified="2016-09-07" version="1">MEINDLLNLIANVGFPVAISAYLLIRLEKQIMTLTYSINKLNTIVSTKLGIVIENEELNKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9Q9</accession>
    <name>A0A174F9Q9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_01585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265400.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44865">
        <property type="protein sequence ID" value="CUO44865"/>
        <property type="gene ID" value="ERS852471_01585"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43842at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021474" evidence="3">
        <location>
            <begin position="35"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="4">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="4">
        <location>
            <begin position="504"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="664" mass="72441" checksum="3AE96EA74D249FDB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FC05</accession>
    <name>A0A174FC05_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Streptomycin adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aadK_2</name>
        <name evidence="1" type="ORF">ERS852471_01627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001255868.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A174FC05"/>
    <dbReference type="EnsemblBacteria" id="CUO47694">
        <property type="protein sequence ID" value="CUO47694"/>
        <property type="gene ID" value="ERS852471_01627"/>
    </dbReference>
    <dbReference type="GeneID" id="60291862"/>
    <dbReference type="GeneID" id="66773966"/>
    <dbReference type="OrthoDB" id="1182556at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007530">
        <property type="entry name" value="Aminoglycoside_adenylylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04439">
        <property type="entry name" value="Adenyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000812">
        <property type="entry name" value="AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO47694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="34552" checksum="8C52BA3E9AD0C5C2" modified="2016-09-07" version="1">MRSEKEVYDIVLNFAKTDKRIRMVTLEGSRTNTNIPPDDFQDFDITFFVTDMDSFTSDDKWLDIFGERLILQKPEDMELFPAVEKGFSYLMLFTDDVKIDLTLLPLELIDEYFTWDKLVKLLLDKDNRIVKPPIPTDIDYHLQKPTQRMFDDCCNEFWNTTTYVVKGLCRKEILFAIDHMNDIVRKELLRMISWLIGIKQGFHFSLGKNYKFMKQYVPEELWERLMSTYNMDSYPHMWESFEQCMALFREVSSEVACQLDYQYPLYDEKISNYVIRQKKKYGIEDDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIY8</accession>
    <name>A0A174FIY8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">chbC_1</name>
        <name evidence="11" type="ORF">ERS852471_01674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265562.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50143">
        <property type="protein sequence ID" value="CUO50143"/>
        <property type="gene ID" value="ERS852471_01674"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425893at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="11"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO50143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="443" mass="47731" checksum="72AF38846024D617" modified="2016-09-07" version="1">MNFMDKFNSVIERALVPVAAKLNAQRHICAVRDAFILTFPLTMAGSLMILLNFVLLSPDGFIANLLNLGELIPNLADYQAIFSPVLKGSTDILAVLVVFLIARNLAKSLGGDDLLTGLTALSVFFIIYPSAVDGGLQTTYMGPQGLFVAIIVGLLVGEILTRLTKTSKLEIKMPEQVPPAVARTFKVLLPIIIVTIGFSVLNYIILQVTDGGGIHTLVYNVLQAPLTKLGDSIWSVVAFGIISNILWVMGIHGPNTVQAVRDVVFAEANAANLKFVSEMGTAWGAPYPNTWALYDAFGNYGGSGMTLGLIIAIFIFSRQRDQKDIAKLSLAPGLFNINESVIFGLPIVLNPMFLIPFVLVPVANVFIGYFAIKFELIPPVAYSVPWTTPGPLIPFLGTGGNFMALVIGFVCLGVSVLLYAPFVIASNKAAEKMNETNDYAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FK50</accession>
    <name>A0A174FK50_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphotransferase system enzyme II, ptcA</fullName>
            <ecNumber evidence="7">2.7.1.-</ecNumber>
            <ecNumber evidence="7">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gmuA</name>
        <name evidence="7" type="ORF">ERS852471_01673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per trimer.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="7"/>
    <dbReference type="EC" id="2.7.1.69" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117287.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50071">
        <property type="protein sequence ID" value="CUO50071"/>
        <property type="gene ID" value="ERS852471_01673"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2038379at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00215">
        <property type="entry name" value="PTS_IIA_lac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34382">
        <property type="entry name" value="PTHR34382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000699">
        <property type="entry name" value="PTS_IILac_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared between all trimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO50071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="11677" checksum="D8BFAD0D89DE78E5" modified="2016-09-07" version="1">MNELELVAFEIISNVGMGKSLAMEAIREGRQGNYELAEQKLEEAKQFLLQGHHAHAGLIQKEAAGEKLEFSLIIMHAEDQLISAETIKDLAFEMIEMHKSLNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNT2</accession>
    <name>A0A174FNT2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sporulation protein YyaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265611.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51381">
        <property type="protein sequence ID" value="CUO51381"/>
        <property type="gene ID" value="ERS852471_01703"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455540at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009665">
        <property type="entry name" value="DUF1256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06866">
        <property type="entry name" value="DUF1256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02841">
        <property type="entry name" value="spore_YyaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO51381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="176" mass="19382" checksum="58471CD655D3BC0E" modified="2016-09-07" version="1">MKRKVNYKSNLSYYEIAEFIRKYITSETVIVCIGTDKCIGDCLGPLVGTFLEESSFPVPVYGTLQSPIHALNIDKKIDEIKKTHPQATIIGIDACLGDTNSIGEIHVRDYPIHPGKGVGKSLPEVGVASIIGIVDSSDNAEFFTSRGIRLSLVFEMARVICHGLNHAYYLNSSYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSB2</accession>
    <name>A0A174FSB2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Comf operon protein A, DNA transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265601.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50995">
        <property type="protein sequence ID" value="CUO50995"/>
        <property type="gene ID" value="ERS852471_01694"/>
    </dbReference>
    <dbReference type="OrthoDB" id="714366at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO50995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="39269" checksum="3965A4F168C5E563" modified="2016-09-07" version="1">MNYKELNSAFKKINNWYEKKSKVLTVKTRPFNTSIVFSNLINKVLYDNGKILYVWCCNDKEQVKKRKREYYNILIGEQEKNHIGDNIHFITIDSLSEVYDEFDLVVLDDITVFSTVSKDELRDAVEEIYWRSGKIIIYSSEYVFPIGNKMELAYLLDNVPIVEPRFILTRIKLENDIPLALYEYFKWFKKNKKRALIIVPSEYMLNKIYNNYYNTLKNDDIRVVKYVKEQSFGFVEDILDGYNDSVFIVTNSIGNYINHINDLNIVMLFSDDELYTYKDIIYLCGSLKVSNEFLPEILLVSKEISEDMDKSKNITREFNQRLWERKVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZB6</accession>
    <name>A0A174FZB6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endodeoxyribonuclease, RusA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265711.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53959">
        <property type="protein sequence ID" value="CUO53959"/>
        <property type="gene ID" value="ERS852471_01755"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1182524at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008822">
        <property type="entry name" value="Endonuclease_RusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="SSF103084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="205" mass="23371" checksum="57057A6B574B3DF5" modified="2016-09-07" version="1">MNTYAKVIVPGSPISKSNFKLHNKDGRAILPYNTGKAHDKYALYEEEIAYYARSQNPTIVFEESLIAILKVYYKSEKRHPDTANITKSIFDGIEKSGLIVNDAQIRRIIVEEFYDKENPRFELELFAESKFSLSYSLIENVDRKDKLLYSSLKKSTKAPIKKKEEKLKSSNSVCSVCNKTVDLNSCVKADGGKTIICRTCFTKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5K8</accession>
    <name>A0A174G5K8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrK_2</name>
        <name evidence="1" type="ORF">ERS852471_01781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265760.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56170">
        <property type="protein sequence ID" value="CUO56170"/>
        <property type="gene ID" value="ERS852471_01781"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO56170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="37341" checksum="3B8B5D5B81DB3DA7" modified="2016-09-07" version="1">MFKEAIDCIDAGTEYCPCHLAASGECILCSQLHGSNFCDCLNWKGVCIYQEFHDNGNKPKEERKVYTCKVVDRILYEDSLLIIKFEAPHKLAIDLAKPGSFIFIRSDENIYYDVPISILESDIDNNVITVMIEVRGIKTKKILDLKKEGNIVIRGPYWNGVFGIKNIEKQKDNHVLVLARGIGMAPMIPVLKKLVQNDNKVTLIVDKQPFEDIYVTEWLDKLGLIPQEMNLIEKGQLSPEGKVAIKSLIKYNNVSLIHIAGADILTYKVIDYLDELERKDIDLSCCNNMKMCCGEGICGSCTARFSGHRVKRLCKVQTDPRSIFGGRRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7C8</accession>
    <name>A0A174G7C8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265848.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58334">
        <property type="protein sequence ID" value="CUO58334"/>
        <property type="gene ID" value="ERS852471_01826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="115" mass="13356" checksum="9E96A4D48EA3401B" modified="2016-09-07" version="1">MIKRKMIIYIVIFAITIIQICLYFNEDNKTTEVISSNEVRVKGNFKEIDIELNEIENLEVLELKDDGEIWSGKVLLSGSKEEVLNSIELLKNYNIINYKIDGNVNDFQVLLDICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8S1</accession>
    <name>A0A174G8S1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">argR</name>
        <name evidence="10" type="ORF">ERS852471_01806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265810.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57478">
        <property type="protein sequence ID" value="CUO57478"/>
        <property type="gene ID" value="ERS852471_01806"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1640037at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="9">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO57478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="16615" checksum="4C6135AF755D7552" modified="2016-09-07" version="1">MKSKRHNKVLEIINQSEIETQEELAEELKKNGFDVTQATVSRDIKILKLVKMQSSSGKYRYVAPSKEERGLNDKLYSILKNAAISAEKVDKFVVLKTLTGTASAVAEAIDNLYTEDVAGTIAGDNTIFILVRTDEKAEELILKVRKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G995</accession>
    <name>A0A174G995_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ORF">ERS852471_01805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265808.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57429">
        <property type="protein sequence ID" value="CUO57429"/>
        <property type="gene ID" value="ERS852471_01805"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="313"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO57429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="566" mass="64863" checksum="FFC5897DABC748F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCK8</accession>
    <name>A0A174GCK8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58599">
        <property type="protein sequence ID" value="CUO58599"/>
        <property type="gene ID" value="ERS852471_01832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16006" checksum="A91E2E0B86C08C6C" modified="2016-09-07" version="1">MRKRGYTLIEVIVVIAILLVIMPIFINGKSTYKLIDTITSKSLKNDIANIISFAKHYSYNTGNTGRLEINTLSGEILFIDTKNEITKNIIAKVTLPKGYKFVSDFKIPVSSKGVVSSNSIIFKSLTGEYHEVTISVGIDLVNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVS6</accession>
    <name>A0A174GVS6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
            <ecNumber evidence="1">3.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hdl IVa_2</name>
        <name evidence="1" type="ORF">ERS852471_01958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266086.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64635">
        <property type="protein sequence ID" value="CUO64635"/>
        <property type="gene ID" value="ERS852471_01958"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="26721" checksum="47A26DA4AFD16334" modified="2016-09-07" version="1">MVKAVVFDLDDTLISERQYIESGFKVVSKFIGDKYNLDNDIVFECMNMLFEESSKEVFNRVLDSFKIKYSKEELLYLIKVYREHTPEIEFFDDVIPTLEMLREKGMKLGIITDGYKETQSRKIEVLKCKELFDEIIITDEFGREFWKPHEKSYKSIAERLGVKLNEMIYVGDNVAKDFVTANELGIATINVNRKSGMYKINRVDRKFLAKYKLNNISDIFDMLFNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GX95</accession>
    <name>A0A174GX95_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol dehydratase large subunit</fullName>
            <ecNumber evidence="2">4.2.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaB</name>
        <name evidence="2" type="ORF">ERS852471_02007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.30" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266177.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66561">
        <property type="protein sequence ID" value="CUO66561"/>
        <property type="gene ID" value="ERS852471_02007"/>
    </dbReference>
    <dbReference type="OrthoDB" id="141570at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046405">
        <property type="term" value="F:glycerol dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036999">
        <property type="entry name" value="Diol/glycerol_deHase_lsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003206">
        <property type="entry name" value="Diol/glycerol_deHydtase_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02286">
        <property type="entry name" value="Dehydratase_LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dehydratase_LU" evidence="1">
        <location>
            <begin position="1"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="553" mass="61390" checksum="EF514C68ECBCCE1E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHS3</accession>
    <name>A0A174HHS3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND family efflux transporter MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72519">
        <property type="protein sequence ID" value="CUO72519"/>
        <property type="gene ID" value="ERS852471_02133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO72519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="49130" checksum="AAAE7295907DEBFB" modified="2016-09-07" version="1">MSMKQKIKKIINFEYVKKGKDTLQKKAVKYLGAFLLIMIGCTMLSRFADSLTIPVIKTEKPKVKTMVDEVKASGRVVKNREEKISTIEGLKIEYVNVSVGALIKAGDVLVELDTEDLQKKIDDINENISRDEKTLARAKEDYNRAIASKNSNVAKALEEMNKAKKELDEYRQLPEASGDGVNEEEPVKDPAVEESLKADYESKKAMYSSAVEDANDTLDLDRNLQDVKDSLKLDDYYAELEKIQPLLDANGKVTSPKEGIVTSVFAQNGGVTSDAIISIADKESGYKFVGQIESSKRTLVKQGQTVALKLNSGNYVENLTIEAISKSEESPDYLNVTVVLPAGTGEIDDMGEIIISSQSKKYSTCVPLAALRQGDNNSYYVLAVSEKETVLGTEKIAKKYEVQIEKKDNEFAALKEGTFSRGEQVIISSNKTVEDGDRVRLETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I1T5</accession>
    <name>A0A174I1T5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endopeptidase La</fullName>
            <ecNumber evidence="3">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lon4</name>
        <name evidence="6" type="ORF">ERS852471_02350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266769.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80421">
        <property type="protein sequence ID" value="CUO80421"/>
        <property type="gene ID" value="ERS852471_02350"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014252">
        <property type="entry name" value="Spore_LonC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02903">
        <property type="entry name" value="spore_lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="4">
        <location>
            <begin position="172"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="5">
        <location>
            <begin position="451"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO80421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="625" mass="69249" checksum="DBCFCB1F22AD1841" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2N0</accession>
    <name>A0A174I2N0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murAB</name>
        <name evidence="7" type="synonym">murA</name>
        <name evidence="9" type="ORF">ERS852471_02329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266743.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79847">
        <property type="protein sequence ID" value="CUO79847"/>
        <property type="gene ID" value="ERS852471_02329"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="419" mass="44792" checksum="E4E290C5B8263AA2" modified="2016-09-07" version="1">METLIINGGNALRGSVEINGAKNAAVAILPAAVLASNQKCIIDNIPDIEDVHCLERILQSLGCVVNKINNNTLEIDATDITTVNACTEDVRRMRASYYFIGSLLARFKKARVELPGGCPIGVRPIDQHIKGFEALGAKVTIEHGAVSVEADELHGANIFFDVVSVGATINVMIAATMAEGTTILENVAKEPHVVDVANFLNKMGADIKGAGTDVIRIKGVKSINGCNYSVIPDQIEAGTFMIAAAATKGDVTITNVIPKHLESISAKLMEVGAIVEEGDDSIRVTVDKPLKGVNVKTAPYPGFPTDVQQPMAALLSITEGRSLVVESIWENRHKHTDELKKMGAVIKVEGRTAIIDGVESLAGSRVRATDLRAGAAMVIAGLIANGETEIIDIEHIDRGYPHIENKFRALGADIRREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4H4</accession>
    <name>A0A174I4H4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosomal replication initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266832.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82093">
        <property type="protein sequence ID" value="CUO82093"/>
        <property type="gene ID" value="ERS852471_02381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaA_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO82093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="85" mass="9893" checksum="C890C62B0DE89A5F" modified="2016-09-07" version="1">MKVINICDKLNSINLTQFLVEKLSDNLDSIKIDTWIKPLEIENNNGDFKIICPNAFHINIIKKRYEDMIMSALESKFSVKSIIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I7J2</accession>
    <name>A0A174I7J2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">trmE</name>
        <name evidence="6" type="synonym">mnmE</name>
        <name evidence="9" type="ORF">ERS852471_02368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266804.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81045">
        <property type="protein sequence ID" value="CUO81045"/>
        <property type="gene ID" value="ERS852471_02368"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="225"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="254"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO81045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="459" mass="50757" checksum="9AABC28888B8D045" modified="2016-09-07" version="1">MKDFDTICAIATALGEGGIAIIRVSGDKALDIVSKVFKAHSGQDIKTMKSYTMKYGHIYDIDNKELIDEVIISFMKGPKSFTAEDTVEINCHGGVVSTNKVLETVIKAGARLAEPGEFTKRAFLNGRIDLSQAEAVMDIIKAKTDLAMKSALMQSTGHLSTQINKQREYMLNILALVEFAVDFTEDDEEVDPSIPLKVAESLEKSISEMSTLLRGADEGKLIREGLSLAIVGKPNVGKSSLLNALLREKRAIVTDIAGTTRDVIEEYINLDGIPVKVIDTAGIRETEDIVEKIGVERSKEKLEEADLVLLVLDTSRELDQEDKDIIESVKDKKCILILNKIDLEWKIESGILDSFENVIKISAKEEIGLDELKQTIKDLFFNGKIDAESLIISNSRHKQALYRALENAENALVRVKNNEYLDLISIYVTAALRALGEITGSELEEDLVNKIFSDFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IH85</accession>
    <name>A0A174IH85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase of the metallo-beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266983.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85841">
        <property type="protein sequence ID" value="CUO85841"/>
        <property type="gene ID" value="ERS852471_02468"/>
    </dbReference>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO85841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="24285" checksum="F2E9B1A131DEAA44" modified="2016-09-07" version="1">MQIKWLGNSSFLIKTSLSKKILIDPFTPLELLDFDTTFDIITFSKDFHKISNFDLSKYGAKIITRDEVYCENSIKIKGYLSYSDNVSGLKRGKNYIYLYEVDKLRICHLGYLGHFLNEEIINILKNVDILFLPIGWNLCLNGNESYKLSELLTPKYIIPMCYKCNKYDFYFDGPLDFISKSKNIYNVNSSEININDLPNNTPLTVLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IRC5</accession>
    <name>A0A174IRC5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rplR</name>
        <name evidence="8" type="ORF">ERS852471_02509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117039.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87485">
        <property type="protein sequence ID" value="CUO87485"/>
        <property type="gene ID" value="ERS852471_02509"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO87485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="13382" checksum="3BFDDE99DFE298FC" modified="2016-09-07" version="1">MFKKVDKNSNRVKRHLRVRKKVSGTPERPRLSVYRSEKNIYAQIIDDVNAVTLVSASTLDKDLNLKVGGNKEAAKLVGELIAKRAVDKGITEVVFDRGGYVYHGRVQVLADSAREAGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IRY8</accession>
    <name>A0A174IRY8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">saeS</name>
        <name evidence="7" type="ORF">ERS852471_02560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90114">
        <property type="protein sequence ID" value="CUO90114"/>
        <property type="gene ID" value="ERS852471_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="251"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO90114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="469" mass="54919" checksum="48DACB1B20BCB46E" modified="2016-09-07" version="1">MISKYIEAKKFCRRWVSNEEANKFKIINERVLIETWLGRVLLIINYFVVRKLVHTTGDRFFPRYDTEASKYIVLLTWVVFAIITFISIVQLVIKNKVYTTDSKISYEKITYYKYRIINSLIRVFILVLFYMTLYQILFQVTMEEIDIKRTILWWIIVVNIVILIYLGFIVAKNYFKGVVLSSTLEEIVGDENYDLSSLKKKIEEKRSKINEINSSDLSITFNAIEDLMNIAENTGIIEKSSFISKTELITNVSHDLKTPLTSVINYVNFLNNEDLTEVKRDEYIDILERKALSLKNLVDDLKDSLGTNTGEVKLEFIEMRVDKLLEKALFEFKERIEDSSLRFNISIEDKEIKRSYADYKKMTRVFHNLISNILKYSAKDSDVYIKLEQEESVDFSRGYYTRIIFKNTTEDEIKMNGEELLERFKRGESSINTEGSGLGLDIANSLMKLQNGELKINVDKNNFIVDVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ISM1</accession>
    <name>A0A174ISM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ttgW</name>
        <name evidence="3" type="ORF">ERS852471_02565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267145.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90344">
        <property type="protein sequence ID" value="CUO90344"/>
        <property type="gene ID" value="ERS852471_02565"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO90344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="22784" checksum="C809A92CC730FD3B" modified="2016-09-07" version="1">MENLKSKAIIKKEKIIDAAVKVFLQKGFEKATVREIAREAGITTGAIYHHYRNKDELIHDAVTKHIHFIDSLNAYKGNSLKPSSEIIDEIKVAASKRLSNLTAQRLHILLTANVLLDENTLLDEYKETYESIISKTSDMFVYTYGIENEKYKKIVASILVAALDGFAIQASLGILDTNDKEYINTITDFFAKLGEHLIISHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IT45</accession>
    <name>A0A174IT45_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267158.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90592">
        <property type="protein sequence ID" value="CUO90592"/>
        <property type="gene ID" value="ERS852471_02572"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1508127at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="121" mass="13660" checksum="74FA02216F500446" modified="2016-09-07" version="1">MKKFLNEKVLVVVDFLEIIIGILLAIFISIAVIYLAGDLISIFTESDKLEAFSSYLDIAFNFVIGIEFIKMLCKHTPETVVEVLLFALARGLIVGHMSNFENLIGILSIVILFATRKYLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ITL2</accession>
    <name>A0A174ITL2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoaspartyl dipeptidase</fullName>
            <ecNumber evidence="2">3.4.19.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iadA</name>
        <name evidence="7" type="ORF">ERS852471_02537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Carboxylation allows a single lysine to coordinate two zinc ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M38 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267090.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88678">
        <property type="protein sequence ID" value="CUO88678"/>
        <property type="gene ID" value="ERS852471_02537"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010229">
        <property type="entry name" value="Pept_M38_dipep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001238">
        <property type="entry name" value="IadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01975">
        <property type="entry name" value="isoAsp_dipep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="54"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO88678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="390" mass="42070" checksum="60AFED6A88059DEF" modified="2016-09-07" version="1">MITVIKNIHVYAPEDLGIKDVVITSNKIEGIYDNVEIPNNFVAIEIIDGKGKLLYPGFIDNHVHILGGGGEGGFKTRTPEMQLSTLIEAGVTTVVGCIGTDGVCRNMRSLIAKAKGLEEEGITTYCYTGSYEIPVKTITDSIKGDMMMVDKVIGVGEVALSDHRSSQATFQDFVNTVASARVGGLLSGKAGIVNVHLGNGARKLEYLSKLIDETEIPPTQVLPTHINRSDKLFYEGELYAKKGGFIDLTTSSDPNFLEPGEIRAGEGLSTLLRNGVDIEHITFSSDANGSMPKFDEQGHLVGLGICSVSSLYREVKESIKEHKVPIEEAIKVITSNVANILKLDNKGRITGGRDADFVIVDEESLDIDMVIAKGKIVVEKGEAVVKGTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IU16</accession>
    <name>A0A174IU16_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na/Pi-cotransporter family protein/PhoU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoU_2</name>
        <name evidence="9" type="ORF">ERS852471_02529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267076.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88380">
        <property type="protein sequence ID" value="CUO88380"/>
        <property type="gene ID" value="ERS852471_02529"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1341748at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="344"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="450"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO88380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="537" mass="57849" checksum="97E7155806F25E09" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IW20</accession>
    <name>A0A174IW20_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91672">
        <property type="protein sequence ID" value="CUO91672"/>
        <property type="gene ID" value="ERS852471_02601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO91672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="36" mass="4032" checksum="EEAF46CE46DA57DE" modified="2016-09-07" version="1">MAKKGQRATWENDNFQAPKKNGVPPVPAISNQKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J3H5</accession>
    <name>A0A174J3H5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_02600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267205.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91629">
        <property type="protein sequence ID" value="CUO91629"/>
        <property type="gene ID" value="ERS852471_02600"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="190" mass="21655" checksum="928974567C3F3C62" modified="2016-09-07" version="1">MKIAICSDIHGNIEAFNRFLEVINAEGIKKVLNLGDFVRGKDPDKIMDYIMNDSRFESITGNHDEAYCLEIEKSATEIDKKYIEWIKTQPGERVVEIEGKKILMVHSRPTSNKCAPLMYNGGTFNEFMDDYPDGMDLVCFGHTHIQLFIENFYGKKILNPGSLGLAIEGKVNFAIIEIDNDDFTCKLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J633</accession>
    <name>A0A174J633_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component NiaX of predicted niacin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">niaX</name>
        <name evidence="2" type="ORF">ERS852471_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267349.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95184">
        <property type="protein sequence ID" value="CUO95184"/>
        <property type="gene ID" value="ERS852471_02680"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1513921at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO95184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="18048" checksum="FD01923BF8CB0112" modified="2016-09-07" version="1">MNNRVKKMVLAGLLVALAIIIPVQFGFLKIVLGPFSATLCSHVPMFLSMLISPVVAIVVGIGSGLGFFITGLPPYIAARALMHAPVGFIGAKIVQKEKNFKKAMVITAPLHGILEALIVIPFGFNLYEMLVVVALGTIIHHAMDASISFVLCKAMAKARRKDLYSAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCQ6</accession>
    <name>A0A174JCQ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation protein YqfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqfD</name>
        <name evidence="3" type="ORF">ERS852471_02726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267436.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97474">
        <property type="protein sequence ID" value="CUO97474"/>
        <property type="gene ID" value="ERS852471_02726"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1194127at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010690">
        <property type="entry name" value="YqfD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06898">
        <property type="entry name" value="YqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029895">
        <property type="entry name" value="SpoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02876">
        <property type="entry name" value="spore_yqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="379" mass="43760" checksum="33E672D54F2F551B" modified="2016-09-07" version="1">MGMNNIRAGRITVEIKLLNPDRILNIFWNRNINIYKINKKNISTIRLDIDYINYEEVCEVIQTLGGKISIVKRRGFIFWLRNMRGKISLVVGLMLFLVVIFLLSNYVWAIDINVQENISPFEIRQQLKEIGIKPGMAKSDIVVEDIEKKLENANSEILWLRVRVEGSTLNVTIEEKINPPTEWNGQYGNLVATEDGEVVKVYTYAGRSAVKQEQMVKKGDVLIEGIDGKEGQEYIIAPRGIVIANTFYEKTMQLKLTGTKLERSGERETEYYISIFGKKIYLKKAIKDFKEYDRIEKSGKIFNEVVYYERIEKKVDITEEEAEKIAIESLEESLKKDLTRDSKVVDKIVKKQLDSDGNLTIKVVFVVEKNIVNDIPVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZK3</accession>
    <name>A0A174JZK3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Forkhead-associated (FHA) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">embR</name>
        <name evidence="3" type="ORF">ERS852471_02826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267621.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02530">
        <property type="protein sequence ID" value="CUP02530"/>
        <property type="gene ID" value="ERS852471_02826"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP02530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="150" mass="16719" checksum="F6863456F5C2CB2C" modified="2016-09-07" version="1">MNISRLITFASGIVFIIILYLIIYYALKIMYKDVKTGGKKNTNPNLNKYGLEITKAGGNEDLEEESVMLIRGDVTIGRMDDNAIILSEPFVSGHHARVYAKNNTLYIEDLNSTNGIYVNDEKVEGKIKLTTGDEIKIGSAIFTVLRADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K091</accession>
    <name>A0A174K091_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267743.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05434">
        <property type="protein sequence ID" value="CUP05434"/>
        <property type="gene ID" value="ERS852471_02893"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="125" mass="13494" checksum="6A1C3849F84EC20F" modified="2016-09-07" version="1">MKREIISTAKAPSAIGPYSQGVKIGELVYTSGQIPVNPATGEMETDIKKATERSMNNVKAILEEAGTSLENIIKTTIFLKDINDFAAVNEVYATFFNANPPARSCVEVGKLPKDALIEIEAIAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEK4</accession>
    <name>A0A174KEK4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">X-X-X-Leu-X-X-Gly heptad repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267829.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07669">
        <property type="protein sequence ID" value="CUP07669"/>
        <property type="gene ID" value="ERS852471_02942"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408193at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026039" evidence="1">
        <location>
            <begin position="32"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP07669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="655" mass="70065" checksum="0E403290D9DA161B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKJ7</accession>
    <name>A0A174KKJ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sporulation integral membrane protein YtvI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ytvI</name>
        <name evidence="7" type="ORF">ERS852471_02981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267910.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09730">
        <property type="protein sequence ID" value="CUP09730"/>
        <property type="gene ID" value="ERS852471_02981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP09730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="361" mass="39585" checksum="AFA4B93BD275EE4C" modified="2016-09-07" version="1">MDLKRGSILEYISQDFINWAKKVVKFLIIYTLGFILLAVSLKYAFPFVIAFIIAILLKPIKNKILSLNKNSKKIKLTNGFVSFLLTITIVILMLSALGAILYEIILQTGKLLEYLTNPSTVEEIINAIDSFVGSILAGLNNLDPSIVEKINEGIMTIVKVISSFATTLGKKMLSLAGSIPGALITVIVTLISTYFFTKEIENIQIGVKNIFSEKGHKLFSTVKDKMNSVFGGYIKAYLLIMLVIAFISSVIFTLARVSYALPLAILTAVLDFLPIIGAGLVYGILAIIMYFSGSKTAAIILLIGYVIVALVRQLLEQNLVASFIGVHPIVMIIGLFIAITPLGFLGMFYFIGAFLLYQTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLE9</accession>
    <name>A0A174KLE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III restriction protein, res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP11326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267992.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11326">
        <property type="protein sequence ID" value="CUP11326"/>
        <property type="gene ID" value="ERS852471_03024"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78859at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="178"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="388"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP11326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="873" mass="102767" checksum="2E0E6673EB4F9A7D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KUA7</accession>
    <name>A0A174KUA7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP14006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14006">
        <property type="protein sequence ID" value="CUP14006"/>
        <property type="gene ID" value="ERS852471_03076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP14006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="33" mass="3722" checksum="364FCEE95E1AC02A" modified="2016-09-07" version="1">MRLTLTRVVFKSLGKDATDVGEARLTLTRVVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KY23</accession>
    <name>A0A174KY23_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Capsular polysaccharide biosynthsis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cap8A_3</name>
        <name evidence="9" type="ORF">ERS852471_03129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268182.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16922">
        <property type="protein sequence ID" value="CUP16922"/>
        <property type="gene ID" value="ERS852471_03129"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP16922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="225" mass="25000" checksum="9EA74306D96FCEBF" modified="2016-09-07" version="1">MEEQVISIEEIFAALKKRWKMIALITILATVVSGILSFFVIEPVYEASTKVFIGKEESSEEGYNSSDIQMYQKLLKTYSEAIKTRDLIDAAIKDSGYDLTTGQVSSGLTVTPITDTQILQIKYQSLDPKECEVVLKSISKAFVKTATDLVPNGNVRIIEGVELPKNPISPNKKMNIAIAFLLGLMVSVGLVFLLEYMDNSYKTKEQLENELEIPVLGVIPNLDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L379</accession>
    <name>A0A174L379_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Single-stranded-DNA-specific exonuclease RecJ</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recJ1</name>
        <name evidence="1" type="ORF">ERS852471_03119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268168.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16275">
        <property type="protein sequence ID" value="CUP16275"/>
        <property type="gene ID" value="ERS852471_03119"/>
    </dbReference>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="284" mass="32434" checksum="604685E0657C635C" modified="2016-09-07" version="1">MRKFWESIYSPNYITGYNPFILKDMNRAIERMVSAINNREKIVVYGIPNVDGLCAISSLILVLKYLNADIEYVVHDDSSGDSSITSKDIINNVHFLGAEVLITLGIGLKSKEEEELCKKLNIDLMVLENKDLKTKCEYIYINPNQKGCQYRYKNLSISGLVFKLMQAIAIYYNIKSINKYLDLILIGEQSANVPLKGENGVILKEGKKFLTNTNNYGLRAIKDAYNITEMNDDDIKQIIKIITPTINVVTMMDNARIIIELLITNRKERAEQITKYLNKSKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L560</accession>
    <name>A0A174L560_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
            <ecNumber evidence="2">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaD_3</name>
        <name evidence="2" type="ORF">ERS852471_03137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.212" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268196.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17288">
        <property type="protein sequence ID" value="CUP17288"/>
        <property type="gene ID" value="ERS852471_03137"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="320" mass="37595" checksum="28D6298F4196F5DB" modified="2016-09-07" version="1">MISVIIPVYNSEKYICNTIDSVIKQTYTNIEIILIDDGSTDSSLDLCRKFEREDNRIRVFNKINGGVSSARNLGVNKANGDYLFFLDSDDILIPNCLEILKREINNNPDSVIISDYKKFYYDEEISIQSLGYDIKTLTIEEFYKQILLLNYDTYPWGTLIKASYFENITFPEHMTCFEDLATMYKVYDKAKKIILINAKLVLYRQSEFSAVKTINIDKIKNYVEATNNFCDYVLEKYPDLSDYQCVFKSYVCLAILQMNNINKSAEIKKNCIRYLESNIKKASKYVVNKRQLIKFTLYKNFKFIFWTFIKIINLKKKFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJ41</accession>
    <name>A0A174LJ41_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268344.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21865">
        <property type="protein sequence ID" value="CUP21865"/>
        <property type="gene ID" value="ERS852471_03222"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1869225at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP21865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="419" mass="49614" checksum="2EB345BB778F6E1C" modified="2016-09-07" version="1">MEILSTGDKIRRARVYEGITLKELCEDKISISKMSCIENGKIKPDEETLKYIATKLKVNYDYLVQDIRGQIEENIRLIDKGNLPREELFKLIEYILNYSINCEYYDLAFIIIHKLFSIYEDSDNIENMQLIIAKYYDIYQKNEIKENTLIYYKDMATFFMKIKEYYEAINYYDKILKILEESNFNDKDLFVRSSFNKGICYMELGEIEKSYSIVEKIISDIDCIKEIQIKGYIYHIFACLSILANKVNADNYIQMSYECLKDDKKSLAKIKDRIGRFFYQIGDDEKGKEETLAAKNMACGYDTIEFIDVLIDCIETFYIYKEFELADEMIDKVLNLSICSENTALIERAYYFKGMLLQKQGQYRQAETYMNISTDYFLKSASVEDTYKRYNEMAELYYNLGEPREAIKYFTLAMNLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XC65</accession>
    <name>A0A173XC65_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amt_1</name>
        <name evidence="8" type="ORF">ERS852471_00009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262680.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49253">
        <property type="protein sequence ID" value="CUN49253"/>
        <property type="gene ID" value="ERS852471_00009"/>
    </dbReference>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="7">
        <location>
            <begin position="8"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN49253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="400" mass="43297" checksum="EF2C924753459CE3" modified="2016-09-07" version="1">MINNGDVAFIILSTLLVLIMVPGLAFFYGGLVERKNALTIMFQIFIAIGVVSLLWIFGGFSLVFGKDIGGVIGNPLQYFAFKDVTFAVNSTYSNNIPFIMFFMYQLMFAIITAPLMTGAFANRLTISGWIKVLIPWMILIYFPVAHWVWGGGFLAKMGFVDFAGGAVIHITSGFGCLGALLVLGKRKYKNEKGPFNLGLVAIGGALLLFGWFGFNAGGTLAAAETAAIVFTNTGVAAATGMIVWLILYAMHSKRASFFEMIVGAVAGLATVTPASGYIDPIGAVIIGAIAAVVCFFCVEFERKKWDDALDVWGVHGMGGFIGTLLVGVLANPRVNGISAGLKQFSIQLIGCLIIIVYSVVMTYIIFKVVDKIKSIKVSDEVQLKGLDQEFFKENYETKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHV0</accession>
    <name>A0A173XHV0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262702.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50215">
        <property type="protein sequence ID" value="CUN50215"/>
        <property type="gene ID" value="ERS852471_00026"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123545at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="149" mass="16749" checksum="B3D501922F60606C" modified="2016-09-07" version="1">MKKVIWSIILSILLIGLVGCQIKTEDNTHKDSLSVEIIATNDANSYKGMPITLKPKVIGEYDKEIQYHWILKSDDDVEGFIVPEKGPQKEIINSGEPVELGLFAEVSWVEGTVIEFKVELQIEDKETSKIIATNEITIENNQGTYSIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJ56</accession>
    <name>A0A173XJ56_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease superfamily</fullName>
            <ecNumber evidence="2">3.4.23.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hybD</name>
        <name evidence="2" type="ORF">ERS852471_00041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262726.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51066">
        <property type="protein sequence ID" value="CUN51066"/>
        <property type="gene ID" value="ERS852471_00041"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1858718at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="17538" checksum="F53D1D54FCB4937A" modified="2016-09-07" version="1">MIKVIGIGNILLCDDGIGVKVVEKIQDSLRNINENIEVIVGETNYQYCIEEIKDDDLVIIIDSTYFMKEPGTVTVRTLDNCDEFLDKIYTGHDISLLKAIRLEKPNIKGFFIGIEIEVIEFSLELSERLQSNFDNICKEVLDNIYSILTSVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMX7</accession>
    <name>A0A173XMX7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
            <ecNumber evidence="1">3.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xynZ</name>
        <name evidence="1" type="ORF">ERS852471_00053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN52015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52015">
        <property type="protein sequence ID" value="CUN52015"/>
        <property type="gene ID" value="ERS852471_00053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="32018" checksum="4D6D4334EEB84CEB" modified="2016-09-07" version="1">MINKVNGVLRMYRIENFSIHIDQLGRDRMVRVYLPGDYDEREDKKYAVLYMQDGHNLFYEETASFGEAWRIQDAVSDIEKQGRDGIIVVGVDCNLDGGRIDEYSPWVNDNLSEFIHSKTLQVAGGEGDLYVEFLVKTLKPLIDKRYRTLKDRNNTFIAGSSMGAFISLYAGYKYKEIFSAIGAFSTAAWFKKDKLMEFIKDNFKKGTKVYLDVGTKETSDEENKDFNRIYVEDTKDIANLLLELGQDSEDLKLIIDEGANHSEASWRKRFPIFLEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPY7</accession>
    <name>A0A173XPY7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2804)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262809.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53633">
        <property type="protein sequence ID" value="CUN53633"/>
        <property type="gene ID" value="ERS852471_00089"/>
    </dbReference>
    <dbReference type="OrthoDB" id="834480at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="PTHR35868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="39850" checksum="AFB019126B731DD9" modified="2016-09-07" version="1">MQGNLSRGKLLDEKGQLIESGWSTKLIKEYSRNDIAASKWRIKEWDYYIITNGKIAIALTFAENSYMSLASVSFLDFLKPSYKTTSEIKLFTFGKNIMPSTTDNGDINYKSKRVDMIFKNDGQTRNLYCRFDKFDNINGKDINLEVNLILTDFPKDSMVIASAWNEDNKSFYYNSKINCMKASGYCIIDGKKYDFDESDSLGTLDWGRGVWTRVNTWYWGSMQTYLDDGRKFGFNIGYGFSDRPNGSENMIFLDGIAHKFDQVTFNIPQLNGKDDFMSPWTFTSNDGKFEMTFKPIIDRIDNTNLGIIESKQHQVFGLFSGQATLSDGTVINIKDKLGFAEKVYNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTC3</accession>
    <name>A0A173XTC3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN55212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262875.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN55212">
        <property type="protein sequence ID" value="CUN55212"/>
        <property type="gene ID" value="ERS852471_00124"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1824706at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN55212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="17097" checksum="13DA569B37A9F548" modified="2016-09-07" version="1">MDGNIEILNFIYQNSEMGTETIKHLIDITEKSTNEEFKNILYSQYNEYNKIFKDSEKMIKDRGHDPKDINKFQKITTYIMINMKTLTDKSPSHLSEMLIQGSTMGVIDATKRINQYDDADKDVLELANKLLDFEKDNQEEWKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0E4</accession>
    <name>A0A173Y0E4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH subfamily 1 protein</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nrnA_2</name>
        <name evidence="3" type="ORF">ERS852471_00160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262940.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57050">
        <property type="protein sequence ID" value="CUN57050"/>
        <property type="gene ID" value="ERS852471_00160"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="190"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="323" mass="35306" checksum="6E3136797A74AD65" modified="2016-09-07" version="1">MDLKSISEILLGAKKIGITYHVSPDGDAVGSVLALLQGLRIINKDAYIISKDKLSENLNYLPTSNEVTGNITEPTEDTDVVIVLDCGNLERVCANLNNFNGVLLNVDHHLSNDFYGDSNYVDTSASATAEIVYELLGLLGVDLSISNEKTLNVATCLYTSLVTDTGCFRHSNVTDRTLLIASNLKKIGVNNTYIYQSLFDNKEFDRVRFIGKVISNMKLVLDGKVALIELPNSFADEFSIEIGDTSDIISYGLQIKGVEVTLLIKEVENGVKCSLRSKNNVDVRKIAEIFGGGGHTKAAGIAIKEKSINEVKEILLKEIEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YN78</accession>
    <name>A0A173YN78_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263159.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64646">
        <property type="protein sequence ID" value="CUN64646"/>
        <property type="gene ID" value="ERS852471_00266"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1390255at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="162" mass="18193" checksum="01DD7D248EE9E3F2" modified="2016-09-07" version="1">MFKTRDFYLMKVYDTNGKYLGAISDIAIDFDEGSIIGFIISSLSIFSKKNFIKKESILSLEDVLIVSSIESYKGLTFNNIKFMDVIDNKNVMKGVLEDLIIDKDTFTVKGMIISSGVIDTMFKGKEIILSSGCVLCEKFILYKGKDYIRLKTLPHNLGGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YW76</accession>
    <name>A0A173YW76_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">stp</name>
        <name evidence="2" type="ORF">ERS852471_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263249.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67225">
        <property type="protein sequence ID" value="CUN67225"/>
        <property type="gene ID" value="ERS852471_00315"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="236" mass="26107" checksum="0AC86FC0EF493D37" modified="2016-09-07" version="1">MVSMKSDKGIVRNLNEDYADFYEGNNYKIYVVADGMGGHNAGEVASKMAVESVIEYINKQDLLEHSLEEAILYANRKIYDLSIKEKSYGGMGTTLTACLVRDNIIEIANVGDSCCFGLNEKGIIKLTKDHSLVQELIDSGSLTEEEGRNHPKKNIITRALGTSKDVVVDIFKIEKNKFKVFLLCSDGLINEVSKEEIFNIITNSKDLDQATNELVSLAKEQGGRDNITVLLFGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBP0</accession>
    <name>A0A173ZBP0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
            <ecNumber evidence="2">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltA</name>
        <name evidence="2" type="ORF">ERS852471_00436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263460.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73711">
        <property type="protein sequence ID" value="CUN73711"/>
        <property type="gene ID" value="ERS852471_00436"/>
    </dbReference>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="49788" checksum="07B980AA29A9D03A" modified="2016-09-07" version="1">MNMQDRMKRTPVTEQAPEVRAKNFDEVCLGYDEERAIKEANRCLGCKNPKCVEGCPVSIDIPGFIAEVKKGDFEAAAKDIAKYSALPAVCGRVCPQETQCEGKCVLGIKGEPVAIGKLEKFTADWSRNNNVDLTFKEASKGKKVAVIGSGPAGLTCAGDLAKKGYDVTVFEALHEPGGVLVYGIPEFRLPKDEVVKAEIDNIKKLGVKIETDVVIGRTVTIDELMEEEKFDAVFIGSGAGLPKFMGIPGENSNGVFAANEFLTRINLMKAYKDDYQTPVKVGKKVAVVGGGNVAMDAARTALRLGAETHIVYRRSEAELPARLEEVHHAKEEGVIFDVLTNPTEIIADENGWVKGMKCVKMELGEPDASGRRRPVVVEGSEFILDVDTVIMSLGTSPNPLIASTTNGLDINKWKCIIADEETGLTSKEGVYAGGDAVTGAATVILAMGAGKKAATAIDEYLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A322</accession>
    <name>A0A174A322_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heme biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydeM</name>
        <name evidence="8" type="ORF">ERS852471_00543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82707">
        <property type="protein sequence ID" value="CUN82707"/>
        <property type="gene ID" value="ERS852471_00543"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024025">
        <property type="entry name" value="SCIFF_rSAM_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03974">
        <property type="entry name" value="rSAM_six_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="91"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN82707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="450" mass="51848" checksum="902138904FEC7041" modified="2016-09-07" version="1">MSLIHKFKQGENYFVLDVNTGAVHIVDELVYDLVDDNILRSKEELIAEFGEKYGADVVSEAYDEIKELVDEEILYSKDQYEEIAHSSMDDRDYIKAVCLNIIHGCNLRCKYCFADEGEYNGHKGVMSVETAKKAIDYVVKRSGPRRNIEIDLFGGEPTMIMDKVKEIIAYARENEKAWNKNIRFTMTTNATLLTDEMMDFMDKEMGNIILSLDGRKEVNDNVRIKVDGSGSYDDILPNIKKMIEKRDKSKHYYVRGTFTGANTDFFEDVKAMVNEGFREISIEPVVLESGHMLELKEEHLPEIFENYDKLYEEMVRRKKEGDEFNFYHFNIDLNGGPCVYKRISGCGAGFEYVAITPQGEVYPCHQFVGKEEFKLGSIYDDTYDTELGKTFKKAHIYNKPKCRNCWARFYCSGGCQSNNFAFNGDMNIPYEIGCKMQKKRIECAIALKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A8G8</accession>
    <name>A0A174A8G8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84962">
        <property type="protein sequence ID" value="CUN84962"/>
        <property type="gene ID" value="ERS852471_00572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN84962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="189" mass="21858" checksum="315AD9C8ED62CA6F" modified="2016-09-07" version="1">MILIWSFSIITSRLEQIKNILNNIEYEYRQRVVIMGKKSFKYKKRKRDKQEKSTYYNDKESEKLQLLAVQQSVIILNIYGQVLLYKAALLGVELVETHFTNNELQIEADTLVKQAVYIFLITGLLSAQLAMINYNLAYEDINNGADYSIQPNIDLITANVLNVTAAIYYIKAANGLYDRDNLQPIFGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIU1</accession>
    <name>A0A174AIU1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-2,6-bisphosphatase</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA</name>
        <name evidence="1" type="ORF">ERS852471_00605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263785.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87445">
        <property type="protein sequence ID" value="CUN87445"/>
        <property type="gene ID" value="ERS852471_00605"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN87445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="193" mass="22489" checksum="416F0ECAF1C7B3F2" modified="2016-09-07" version="1">MKKILYLMRHGQTLFNVRRKVQGWCDSPLTNLGIRQATIAGEYFKANNITFDHAYSSTSERACDTLEYVSNTPYKRVKGLKEWNFGTFEGESEDLNPPLPYGDFFVKYGGEDEFELRNRVAETLYSIMKNDDHNTVLAVSHGAACRQFMRYWAHTSDVDQKERLGNCCILKFEFENDKFKLLEIINHDFSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANG8</accession>
    <name>A0A174ANG8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murR_3</name>
        <name evidence="3" type="ORF">ERS852471_00645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263856.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89753">
        <property type="protein sequence ID" value="CUN89753"/>
        <property type="gene ID" value="ERS852471_00645"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="126"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="283" mass="31524" checksum="0D1743CE92446D63" modified="2016-09-07" version="1">MENKTIRDRIFAEYNNFFDAEKKIANYILNNSSKVVELTIAELAEAAGTSEATVSRFCKKCNVKGFHHLKITLAKELVKGCESEVTASGDVNQNNIKKSLQNILANKVEELSQTVSMIDEENLLRIIKLISGARSIQFAAVGNTIPVAMDGSYKFNQIGIPAVANTIWETQIAYTYNLTKEDVVIVISNSGASKRLLNVAEVAHKKEAKVISITNSANSPLAKISDYHITTATREKLFLDEYYFSRISAMTVIEILYLFLTVGKEDVYDNLSRHEQSIADDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B430</accession>
    <name>A0A174B430_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybbH_1</name>
        <name evidence="3" type="ORF">ERS852471_00712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263992.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95851">
        <property type="protein sequence ID" value="CUN95851"/>
        <property type="gene ID" value="ERS852471_00712"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="110"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN95851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="251" mass="29687" checksum="7419F572F36C1809" modified="2016-09-07" version="1">MKIHRRISENSKYLTKLEKELLQLLLENSALFKYDNFTIANISEKFSISNTSVHRLSKKLGYKSFIQFKDDYFQRDKLEEENKPNIDDTDFVNLMLDTYKLVKQSDIDEIVEKMMKCKRITIYGMGMSNYLGKIFQIKLQLLGIPAEQHDDSRFMRLSSRILNKDEDLVFMLSRSGETPELLEVLVETNLRGVDVVLITESRNSTFEKLCKYKVYTAYTQDSDSNIDTRLNFHIAMDYIIKKFIEKYEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9W2</accession>
    <name>A0A174B9W2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin biosynthesis mog protein</fullName>
            <ecNumber evidence="2">2.7.7.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mog</name>
        <name evidence="2" type="ORF">ERS852471_00721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.75" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264006.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96425">
        <property type="protein sequence ID" value="CUN96425"/>
        <property type="gene ID" value="ERS852471_00721"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="163" mass="17782" checksum="B4ED7D5CD5B8C841" modified="2016-09-07" version="1">MYTVGIVTSSDKGYAGEREDKSGAVIKEIVEAKGFEVVRYVVLPDEKEMLAEEFKHMADDLGVNLVLSTGGTGFSVRDITPEATKMVIERETPGICEAIRYFSLQITKRAMLSRAVSGIRKNTLIVNLPGSPKACKEALDFVLDDIKHGIDILLGSASECARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BB87</accession>
    <name>A0A174BB87_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264051.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97693">
        <property type="protein sequence ID" value="CUN97693"/>
        <property type="gene ID" value="ERS852471_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4397" evidence="1">
        <location>
            <begin position="111"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="204" mass="22518" checksum="6DB585F75A7B5187" modified="2016-09-07" version="1">MTYIRLNTPDVNSSIRILHAVPNAPNIDVYANGSLILSDLSFSSISNYLNLSPGTYELQVYRSGFYDTPLATQSVQLAPSANYTISVVTLGGLFLFKLRDASIATSTEYTYLRFMNLSQSAPLLNLDLPNGNELFTAVEYLETTGYYTTSPGIYNFRVESTGGTALNKNIKNLTLEGGKLYTIYILGIFNGNPPLGYLFVEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBH4</accession>
    <name>A0A174BBH4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class V aminotransferase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csd</name>
        <name evidence="5" type="ORF">ERS852471_00747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN97793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264057.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97793">
        <property type="protein sequence ID" value="CUN97793"/>
        <property type="gene ID" value="ERS852471_00747"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="31"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN97793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="433" mass="49079" checksum="2086656CE2A3B47F" modified="2016-09-07" version="1">MHKTNMEKIRELFVGIDKKIEVEGKGKIVPINFDNAATTPAFKRVLKRILECSEMYGSIARGDGQKSQFCSDTYDECRKYIMNYFNAPEDLYTAIFTDNTTMGLNRLSNILIKDREDIVITTRMEHHSNDLPWRGKCNLKYLEVDENGRVKVDELEELLIKYCGKVKYVTISGASNVTGYLNDIRKVAKLTHKYGAHIIVDGAQLVAHKKVSMLGVKSDENIDYLVFSAHKMYAPFGCGAIIGLKETFNYYPPDIVGGGIVYIVRDEGQIYLDTPEKNEPGTPNFFGVVAMTQAMKDMERIGFKTIEDNEKNIFSKLLEGMKNIADVNLYGDCENIDDRLGIMVFNINGMNYEEVGEKLASIRGIAVREGGFCAHPYTRRLLGIKDKDLDEYIGKNGIPGMVRASLGIYNTEKEVDIFLDTIEYICRRYLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIJ0</accession>
    <name>A0A174BIJ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dedA_2</name>
        <name evidence="2" type="ORF">ERS852471_00804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264170.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00861">
        <property type="protein sequence ID" value="CUO00861"/>
        <property type="gene ID" value="ERS852471_00804"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="169" mass="18963" checksum="25BCAB46BAB1AF95" modified="2016-09-07" version="1">MDGNSIMNNITQYGTIVIFLIIFLENLNMPGFPAGVIMPIVGLWASKHNENIIFIVILSVIASLLASWILYFIGFYGGNYILDKYTKRFPKQSEYIDEKLEYLRRKGNVGVMISRMIPMARTIIPVPAGVLKLNFLKYTAYSAIGILIWDSTLICSGYILGDGVIKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BS57</accession>
    <name>A0A174BS57_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264264.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03594">
        <property type="protein sequence ID" value="CUO03594"/>
        <property type="gene ID" value="ERS852471_00857"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="241" mass="26751" checksum="38B3A4D68C952FC7" modified="2016-09-07" version="1">MKVTIIGCDGAYPRVNGATSAYLVEDKDTKVLLDCGSGAISRLQNHIELRELDGIVISHYHADHYADLECMQFATMLDTFEKKRENSLIIYGPGKEQMLTYKNFCVGKSFKGKENFTIGSLTFETILNKHGIEAYSIKVTNEDGECLVYTGDTGYYDELPIFCEGASLLIAESSCYEYERGNLSGHMTGGEAAIVAEKSGVDTLILTHLPHYGDIEKMTDEAKQFFNGEVILARYDSCIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C248</accession>
    <name>A0A174C248_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Site-specific DNA recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hin_1</name>
        <name evidence="9" type="ORF">ERS852471_00875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO05985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264316.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05985">
        <property type="protein sequence ID" value="CUO05985"/>
        <property type="gene ID" value="ERS852471_00875"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="8">
        <location>
            <begin position="166"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="397"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO05985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="558" mass="64264" checksum="2D8EC20EDE1BBB15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8E7</accession>
    <name>A0A174C8E7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264429.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09067">
        <property type="protein sequence ID" value="CUO09067"/>
        <property type="gene ID" value="ERS852471_00933"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018977" evidence="1">
        <location>
            <begin position="34"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="117"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO09067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="634" mass="69994" checksum="519870DAE6F3977F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8J0</accession>
    <name>A0A174C8J0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">btr_1</name>
        <name evidence="7" type="ORF">ERS852471_00924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264411.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08569">
        <property type="protein sequence ID" value="CUO08569"/>
        <property type="gene ID" value="ERS852471_00924"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="311"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="413" mass="48406" checksum="96BE43BFF1FFE020" modified="2016-09-07" version="1">MKIVVVDDDKIIRLGLTKIIKRLFEQHEVISDFNNGAVALEYLRDNKVDLVITDIKMPIMTGSELIEKSAKELDNPPVFVVLSGYDEFTYVRDTMKSGAFNYLLKPIKQEELKKVIEEVEVKIKENKKQDKLLSKSIEVLKKDFFKHILFSNVETNYKTDRSLLENIQLNENYKYKMTIVQRDGNNDKTIISNFIRDILELNKDVEYLSFYFEDNVYIVFYLECSEVNLINKLTEDIISKADSLVENDKNVFIIEYTDKVWQLREQSRLFRKLKNNISSESKAKKYILSLSEEMNNNIYDENEKTNVTAIKLAKQYIIKNFNKNITLKEVADEVFLSQNYLSELFKKEMGEGFYDFLSRYRIQVAKDLLLTTNLRVYEIAENVGYNDSITFGRAFKKITGATPNSFRNNRVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C908</accession>
    <name>A0A174C908_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264445.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09453">
        <property type="protein sequence ID" value="CUO09453"/>
        <property type="gene ID" value="ERS852471_00941"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="278" mass="31075" checksum="BB6AAEFF7C7D6778" modified="2016-09-07" version="1">MQKIKIITDSTLDIPVDLIKKNDIEVMPLLINFGEDSYLDGVDITPTEMIERINRENVLPTTAQITPTRFEETFKKYLDQGYKIVTLVLSSEMSGTYQSACIAKDMLETEDIVVIDSKNVTSGLGLLVLKACRLRDNGASIKEIEEEILKTRDKVKCTLNFESLDNLVRGGRLPKVAGAIGTALGLRLILEIKDGKMAVKDKVRGSKKAFKKLISDFESADVDFKEPVILTDLLNEDVYFELKKYLEEKDIEYVDAKVGCTVGIHSGIKPCGLFFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9Z3</accession>
    <name>A0A174C9Z3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">manA_1</name>
        <name evidence="6" type="ORF">ERS852471_00927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08705">
        <property type="protein sequence ID" value="CUO08705"/>
        <property type="gene ID" value="ERS852471_00927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO08705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="38467" checksum="D5BEA7DFFDFD3A9F" modified="2016-09-07" version="1">MEEKEISELDIPNFSLSNKNASIECKKLMKYFSSIFEKGIISGQHCNKATMPDIEYIRRVTGKVPAILGFDFLSYSGEIETPESTFECIDELVNNKGSVEAALYWAKNTNAIITFCWHWFSPLNGKDKSFYTKNTSFDLVKALIDGTEENLALIRDLDMIAYELKKFKDANVPILWRPLHEACGGWFWWGAYGKEAYIKLYRLMYDRYVNYHNLNNLIWVWNSPDKEWYPGDDVVDINSADYYSSLGDNRPLIEEYNTFYSIPTTKKPLALGENGPIPDPELIKSSKAYWLWFMVWNNVSEKIVWNSNDVLKRFFNDDFLITLEDLPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCG7</accession>
    <name>A0A174CCG7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="10" type="ORF">ERS852471_00938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264439.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09306">
        <property type="protein sequence ID" value="CUO09306"/>
        <property type="gene ID" value="ERS852471_00938"/>
    </dbReference>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO09306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="339" mass="36069" checksum="635921E7F2C81DE8" modified="2016-09-07" version="1">MANVRVAINGFGRIGRLAFRQMFGAEGYEVVAINDLTSPKMLAHLLKYDSAQGRYELGDTVVAGEDSITVDGKEIRIYAEADANKLPWGEIGVDVVLECTGFYVSKAKSQAHINAGAKKVVISAPAGNDLPTVVFNVNQDILTAEDTIISAASCTTNCLAPMAKALNDYAPIQSGIMSTIHAYTGDQMILDGPQRKGDLRRARAGAVNIVPNSTGAAKAIGLVIPELNGKLIGSAQRVPVPTGSSTILVAVVKGENVTVEGINAAMKAASNESFGYTEEELVSSDIIGIKYGSLFDATQTMVSELGNGLYQVQVVSWYDNENSYTSQMVRTIKYFSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFG5</accession>
    <name>A0A174CFG5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_00967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10710">
        <property type="protein sequence ID" value="CUO10710"/>
        <property type="gene ID" value="ERS852471_00967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="35"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="218"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="361" mass="39568" checksum="8350C9D4D0D06EE6" modified="2016-09-07" version="1">MMSMLEALRDRKTRDSIILFIISLGCFFINTTNIVLGLVIHSIAMIPLAFMLGEFTSSISEYIGEKKGGLLTATLGNLPEIIMGIWSLRLGLISMVQAAMIGCIVNNMLLVLGVSILLGGLKYKQQTFNKNNAKTNFSMLLLAMSSMVVMACINNYSSIPSETVIKISAVVSIILICVYLLGLIYSLYTHSNLILGDDKTEKIEEKKSDKRELVILLIKIFVISLAIYFLSEKVINDANIIIENFNISEGFMGIILIPVLGNIGENISAIMCAVRNKVNLSLEIAIGSGIQIALFATPILVLTAFLLGIQMALVFSVLNIIIAGLAIFMSYIVFVDGSTNWFEGIVLIAVYVIITICYFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CI15</accession>
    <name>A0A174CI15_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.12</ecNumber>
            <ecNumber evidence="3">1.3.1.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tyrC</name>
        <name evidence="3" type="ORF">ERS852471_01006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="3"/>
    <dbReference type="EC" id="1.3.1.43" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264538.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12774">
        <property type="protein sequence ID" value="CUO12774"/>
        <property type="gene ID" value="ERS852471_01006"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047794">
        <property type="term" value="F:cyclohexadienyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="31052" checksum="ABCDA470DBF9F8F6" modified="2016-09-07" version="1">MNIVIIGLGVIGGGYAMALKEAGYTEVYGVDNNIETLEKAKFLGIIKEGCLTGESVIPKADLIVLAVYPDLVKKFIQNNIKLFKDGLVITDVTGIKEPFIEEVTAILPEDIDFVFGHPMAGREKKGIDYATNTVFKGANYLITVTPKNKEKNISLIEDLAYKMGFKRVKKISPEYHDEMIAFTSQLPHALAVALINSDIEGRDTGSFIGDSYRELTRIANINETLWSELFLGNKNNLIVSIENFQRELERIKECIKNDNKEGLEKLFIKSTKRRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CME7</accession>
    <name>A0A174CME7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">aroK</name>
        <name evidence="3" type="ORF">ERS852471_01009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264541.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12915">
        <property type="protein sequence ID" value="CUO12915"/>
        <property type="gene ID" value="ERS852471_01009"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="19418" checksum="A7716920C021BEBD" modified="2016-09-07" version="1">MEKTKKNILLIGMMGCGKTTLGKILAKKLSYDFIDMDSYIEEISNDTISNLFKVSEDNFRNWETESCRRLSKLKHTVISAGGGIIKKDINMKLFDENSIIVFIDRPIENILEDIDVSKRPLLSDGKEVLYKLKEERYDLYNKYCDYRIVNDGSIEEALYGIVEVIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0E4</accession>
    <name>A0A174D0E4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264627.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19211">
        <property type="protein sequence ID" value="CUO19211"/>
        <property type="gene ID" value="ERS852471_01107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="20518" checksum="79D7F08A7A710E13" modified="2016-09-07" version="1">MTKEKRLETEVVLCEGKTDIFKEVLFSFADAAATALPFFIEDVNVKLQNVVLDVVDGKCCDAIIFSAELFVNVIYKTRGDVAADGTVTGTVNHRTTVVPISGCIPVNCEKIKKCDKNVKAKLIDVCIAESHVLRNILAGDATSAFPRYRTIAEQVCIKIKAKVVTDEIVTLKFEDEDDKDRKCKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4C0</accession>
    <name>A0A174D4C0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20097">
        <property type="protein sequence ID" value="CUO20097"/>
        <property type="gene ID" value="ERS852471_01124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO20097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="187" mass="21987" checksum="1D2A9C9FB0D0BC3E" modified="2016-09-07" version="1">MRAYEEILLGEIFMDLLLYFLFNFFIYGFIGWILENGFCYFKTGHVQKDGFLYSPFKPMYAIAMSVLVLCSKSKSIDTYTLATLCLIIPTFVEFVTGLIMREYFKKDYWDYSEVKYNYKGIICLEFSLIWTVLSFIAVRYIQIGIVDRVYSSIKGYWGNTWYLFVIALVLDAIKTIKVMQIKNKAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D592</accession>
    <name>A0A174D592_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase-like FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264624.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19056">
        <property type="protein sequence ID" value="CUO19056"/>
        <property type="gene ID" value="ERS852471_01104"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="134" mass="15430" checksum="24EFE8F013EFEC95" modified="2016-09-07" version="1">MNEVIKFLNDNPVQYFSTVGLDGRPKVRPFQFMLEKEGKLYFCTNNEKDVYSQIQNNPYVEICTSTPNFAWIRLSGKAKFTKDLDIKKSIIEHSPLVKSLYQNAENPIFEAFYLEDAKATIADFSGNPPVTYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DDD2</accession>
    <name>A0A174DDD2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_01172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264686.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22349">
        <property type="protein sequence ID" value="CUO22349"/>
        <property type="gene ID" value="ERS852471_01172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1376978at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO22349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="270" mass="30469" checksum="ABAEAFAD8147A441" modified="2016-09-07" version="1">MNIFKFEFKRQFKSLIIWSIVCSALVIMFMALFPSMKDMGMQELVGDKLGAMPSTLLEAFNIDEMMDFSNIKDYMGYCLQYIVMAAGIYGLILGASALSKEEKDGTIEFLYSKPITRNKIVTSKLLASIVIIFIFIFIIGLVTMAIGIIVKPEDIKTIDLLMDIKIMYIGMAMLSYTFMSIGFLLSMIIKARTNVTAVALGVFFASYFVGVLGKLKESFEWLIYFSPTDYFIPAKIFKDGFELRYVIVATVLILVSIVGTYIIYNKKDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJL1</accession>
    <name>A0A174DJL1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WxcM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264736.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25751">
        <property type="protein sequence ID" value="CUO25751"/>
        <property type="gene ID" value="ERS852471_01217"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20292">
        <property type="entry name" value="cupin_QdtA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="16389" checksum="290F8C51B8F43729" modified="2016-09-07" version="1">MYNVALIKFKNISSECGHLIPIEGNIDIPYEIKRIFYIYGVPKDKKRGNHSHRSLYEILICLKGSLKVKVQNGREEEVYVLNNEYEGLMIGPWIWNEMFDYSDDCVLLVLCSDKYDESEYLRDYDVFLKEVNEIYKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM02</accession>
    <name>A0A174DM02_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264751.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26434">
        <property type="protein sequence ID" value="CUO26434"/>
        <property type="gene ID" value="ERS852471_01232"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="30717" checksum="F48693260410F313" modified="2016-09-07" version="1">MVKCDFHTHSTASDGSFSPSEVVKKSFDKGVKYLALTDHDTLTGIDEAKNMAESLGMTFIPGIELSTSHNKETVHLLGFFKGDDYKDTELNNFLQELKDKRIRRAEEIVARLKKFNNIEIKVEDVLKNGKDTIARPHIAKTIIEAGYPYDYDYIFKNFIGDDCPAYIPANKMSTEEGISLLRKYNAKVFLAHPVLLKKISVNDILPLGIDGLEAVYALNTPDEEKKFRKFANKNNLLISCGSDSHGMEEDNGHGSLGSMSLDEESLEKFINSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWI2</accession>
    <name>A0A174DWI2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hflX</name>
        <name evidence="8" type="ORF">ERS852471_01278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264837.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28619">
        <property type="protein sequence ID" value="CUO28619"/>
        <property type="gene ID" value="ERS852471_01278"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045498">
        <property type="entry name" value="HflX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19275">
        <property type="entry name" value="HflX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="364"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="323"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO28619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="597" mass="67408" checksum="FB8606633B282036" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DX28</accession>
    <name>A0A174DX28_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="8">2.4.1.129</ecNumber>
            <ecNumber evidence="7">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ponA_2</name>
        <name evidence="21" type="ORF">ERS852471_01274</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="8"/>
    <dbReference type="EC" id="3.4.16.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264829.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28420">
        <property type="protein sequence ID" value="CUO28420"/>
        <property type="gene ID" value="ERS852471_01274"/>
    </dbReference>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="10 21" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Transgly" evidence="20">
        <location>
            <begin position="86"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="19">
        <location>
            <begin position="413"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="878"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="887"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CUO28420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="929" mass="102548" checksum="D03C7ED794E824D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0I6</accession>
    <name>A0A174E0I6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobQ_2</name>
        <name evidence="4" type="synonym">cobQ</name>
        <name evidence="6" type="ORF">ERS852471_01303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264881.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29805">
        <property type="protein sequence ID" value="CUO29805"/>
        <property type="gene ID" value="ERS852471_01303"/>
    </dbReference>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="250"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO29805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="493" mass="54504" checksum="61AF22C60294EF36" modified="2016-09-07" version="1">MAKIMIQGTGSSVGKSILVAALCRIFTQDGYKVCPYKSQNMSLNSYITLDGKEMGRAQVLQAYASGIEPEAYMNPILLKPTSDRKCQVIVNGKVFLNTDAKGYHNLKDEFKVMLKNDFEKIEENFDIVVMEGAGSPAEINLRENDIVNMGMAELVDAPVIIVGDIDKGGVFASLAGTLLLLSDSEKERVKGVIINKFRGDIDLLTPGIDMLTDIIHKPTLGVVPHFTLNLEDEDGFMASSIEREGRGDIDIAVIHLPHISNFTDIDALKVEEDVSVRFISKANDFGNPDLVILPGSKNTIDDLIYLRNSGLEEKLLEYSKSGRILGICGGYQMLGEEILDPHKVESENLSVKGIGIIPCITKLTTEKTMTRSEGITSLGDKVYGYEIHMGETIAKGEYNYFVNLTSSNGEETSINDGYISEDRKIMATYLHGVLDSSSFRETILNAIRREKGLIEKKSSKYEAIRDKEIDKLASIVRESIDIDSIYDIMGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2N0</accession>
    <name>A0A174E2N0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO30310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30310">
        <property type="protein sequence ID" value="CUO30310"/>
        <property type="gene ID" value="ERS852471_01314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017037">
        <property type="entry name" value="UCP035261"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035261">
        <property type="entry name" value="UCP035261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="277"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO30310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="692" mass="77204" checksum="3CCD098440F996AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBM6</accession>
    <name>A0A174EBM6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ORF">ERS852471_01376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265017.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33996">
        <property type="protein sequence ID" value="CUO33996"/>
        <property type="gene ID" value="ERS852471_01376"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="483" mass="52549" checksum="7CF571C9FA48AF93" modified="2016-09-07" version="1">MINSSIDIMDPANGKFKDECGVFGIYVNKPVDVASVTYYGLYALQHRGQESAGIAVANGEEVKIHKGLGLITEAFNSDNLDYLKSLNGNISVGHVRYSTAGAKTVENAQPLLANTKLGPIAMAHNGNLVNADVIRELLEDGGHVFHTSVDSEVLASLIARGSKRGIERAVVNAISAVRGSFAMVIMTKDKLIGIRDPHGIRPLCLGKIDEGYILSSESCALDSVGAELVRDIEPGEIVVIDSDGVKSIKYSEGTTCQTCAFEYIYFARPDSVIDELDVYNTRVKQGEVLYQEHKIDADLVVAVPDSGIPAAVGYSKASGIPYEMGFVKNRYVGRTFISPSQELRERAVAVKLNPLKVNVKGKRVILIDDSIVRGTTSKHLIDSLRRAGATEVHFLVASPIVKFPCYFGIDTPYRSELIGANKSVEEIRETIGCDSLGYLSLEGMYEGFYGRRNFCVGCFNGVYPVSAPMEKLNENLEEEEVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYU5</accession>
    <name>A0A174EYU5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lytC_2</name>
        <name evidence="2" type="ORF">ERS852471_01548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265326.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42984">
        <property type="protein sequence ID" value="CUO42984"/>
        <property type="gene ID" value="ERS852471_01548"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006637">
        <property type="entry name" value="ChW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07538">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00728">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="370"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="513" mass="57293" checksum="F52F969E975F3C95" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F975</accession>
    <name>A0A174F975_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265414.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45219">
        <property type="protein sequence ID" value="CUO45219"/>
        <property type="gene ID" value="ERS852471_01592"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO45219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="96" mass="11092" checksum="A849035929B66E94" modified="2016-09-07" version="1">MNLDKVVLEEIVEISKKHNEINKVILFGSRARKDNGDRSDIDLAIYSEASISEFIEDIENNTTTLLEFDFSDMKSVSDELFINQVNKEGIIIYEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9J3</accession>
    <name>A0A174F9J3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LicD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265463.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46391">
        <property type="protein sequence ID" value="CUO46391"/>
        <property type="gene ID" value="ERS852471_01619"/>
    </dbReference>
    <dbReference type="OrthoDB" id="958629at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="269" mass="32441" checksum="F6B3EECF827BA677" modified="2016-09-07" version="1">MDRIKEICLDTAYEFINICEKYNLRYFILGGTLLGAVRHKGFIPWDDDIDFGMPRKDYEIFMQIAKDELSENKSIKTYKDKNSKQYFIQVMDNRTKIKMTSNAVSRYENVWVDIFPLDGMPNGRIKRFIHKNYLLYRKMLIQFSDYENRINLKIRNRPIHERVLIWIAVNSKVGNILKTDKCLELMDKALKKYDYDECEYIVNFFGAYKFKEMFPKDYYKNGTMYNFENMKLVGPINYDEVLKQMYGEYMKLPPEEDRGYHHSYEIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAW7</accession>
    <name>A0A174FAW7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetobutylicum phosphotransbutyrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265440.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45799">
        <property type="protein sequence ID" value="CUO45799"/>
        <property type="gene ID" value="ERS852471_01606"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2074871at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021507" evidence="2">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="3">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO45799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="19461" checksum="0F682DBA8F08814A" modified="2016-09-07" version="1">MNKKLMFILLVILAIGFIFFNSSKSGSESNYISKSLVSRFIANKETTEVFNDFRSDKSEYDLNNLYSKMNFIVRKLAHGTEYFILAFSLVMLFNNFNIRFREKFIYSLFIVLIIALLDEFYQMYVPDRSSLVSDIVIDFIGGILGSLISSLVIYIRRSFNKPYDSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCC3</accession>
    <name>A0A174FCC3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO47922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265485.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47922">
        <property type="protein sequence ID" value="CUO47922"/>
        <property type="gene ID" value="ERS852471_01631"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1266542at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021543" evidence="1">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO47922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="220" mass="24766" checksum="BEFBA46BBC3E1408" modified="2016-09-07" version="1">MIKRTVAIGLSTVLVLGMIGCSNNKENANNDVTNIKVEAREALPGEWSQDLTREEVAELNKEILSRVEETATFYGLDYEITEEVKEDTNGLSINDNHINIDIEDPEPNRIESMYYGFKQYGTDLASGELVMKISSILDKKAIEEEGTFDFGATSFSTFSEAFTGVTGRDYSELNQQIYDMITGNNNVTTIENNLDGVRETISITDDFLLYTLQTKEYQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FD36</accession>
    <name>A0A174FD36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolysaccharide tyrosine-protein kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywqD_2</name>
        <name evidence="3" type="ORF">ERS852471_01624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265473.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46746">
        <property type="protein sequence ID" value="CUO46746"/>
        <property type="gene ID" value="ERS852471_01624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="12639" checksum="5F858EC426C3A21C" modified="2016-09-07" version="1">MVKYNENLTIVSAGRVSPNPSEMLGSKAMGIFLEEMKSHFDYVVMDTPPLGAVTDAQVLSTKVDGTILVVKAGATKKDVVMNSVNLIKKVNGNLIGTVLNGVENSKNKYYYYYGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFD1</accession>
    <name>A0A174FFD1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">ERS852471_01637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265497.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48237">
        <property type="protein sequence ID" value="CUO48237"/>
        <property type="gene ID" value="ERS852471_01637"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO48237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="200" mass="23369" checksum="713A82CE6D9336D5" modified="2016-09-07" version="1">MKRYGIMGGTFNPIHLAHLYIAYEAKEQLDLDTIIFMPAGNPPHKRKNSIIDSSFRLDMVKLAIEDYKDFIVSDYEIEKQGLSFTYETLKALKSDDVQLYFIAGGDSLMDIEKWRNPDQVLQNCNFVVFNRGQFSVEELEHQKRKLEEKYQANIILLNVANIDISSSMIRERLEEGKRVDFFLPDKVLKYIVDNRLYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQQ3</accession>
    <name>A0A174FQQ3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ComF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265599.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50949">
        <property type="protein sequence ID" value="CUO50949"/>
        <property type="gene ID" value="ERS852471_01693"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="214" mass="24534" checksum="04D8B4293A02B168" modified="2016-09-07" version="1">MGKKSIKEIRAVISAILDLIYPPLNKCIVCSSEGFIGICPLCESKIKRVEKQDHILSYGYYGGILKELILAFKYEKNFTAAKIISELLLDLIYERKIECDVICYVPMSKNSIKKRGFNQCEVIAKHLSEELNIPVSKSLIKIKDTKEQKSLSKEERYKNIKDAFEIRDKKILNKRILLIDDVVTTGATLLECEKIFKKYNVEEITVLTIAKSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUC6</accession>
    <name>A0A174FUC6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thlA</name>
        <name evidence="7" type="ORF">ERS852471_01719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265641.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52219">
        <property type="protein sequence ID" value="CUO52219"/>
        <property type="gene ID" value="ERS852471_01719"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="271"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="393" mass="41428" checksum="CFB881A7A725F938" modified="2016-09-07" version="1">MREVVIVSAVRTAIGSFGGALKDVPAVDLGSLVIKEAVNRAGIKPELVEEVLMGNVIQAGLGQNVARQASVKAGLPVEVPAMTINMVCGSGLRTVSLAAQMIKTGDVDIVVAGGMESMSQAPYALKSARWGQRMNDGKMLDTMINDALTDAFNNYHMGVTAENIAKEWGLTREMQDEFSLNSQLKAEKAIKDGRFVDEIVPVVIPQRKGEPKVFAQDEFPRFGSTIEGMAKLRPAFIKDGTVTAANSSGINDGAAAVVVMSAEKAAELGIKPMAKIVSYGSKGLDPSIMGYGPFYATKKALENTGLTVEDMDLIEANEAFAAQSLAVAKDLKFDMSKVNVNGGAIALGHPVGASGARILVTLLHEMEKRDAKKGLATLCIGGGMGTALVVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWC7</accession>
    <name>A0A174FWC7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB</name>
        <name evidence="4" type="ORF">ERS852471_01722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265647.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52395">
        <property type="protein sequence ID" value="CUO52395"/>
        <property type="gene ID" value="ERS852471_01722"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO52395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="16448" checksum="80863CC773949A42" modified="2016-09-07" version="1">MKIALGCDHGGLNLKAEIANYLKSQNIEFKDFGTYTEESCDYADIALPVAEAVVAKEYDFGILICGTGIGIGIAANKVPGIRAALCSDTFSAHATREHNDANILTMGERVVGKGLAIDIVKAFLGAEFEGDRHVRRLEKITKIEEKYRNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G020</accession>
    <name>A0A174G020_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppC_3</name>
        <name evidence="7" type="ORF">ERS852471_01776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO55892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205674.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55892">
        <property type="protein sequence ID" value="CUO55892"/>
        <property type="gene ID" value="ERS852471_01776"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO55892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="323" mass="35259" checksum="C5F27C479CE6133A" modified="2016-09-07" version="1">MVKKIFNFKIVKFLKESPKTAVGLALILIVLILTLGADLFTPYEPMQTFDGLWRVAPSADHILGTTQAGKDVWAQTLYGGRVSISVGIFAGSIAVVLSLIVGITAGYFGGVVDNIITTIINVIMVIPQTVLLLIIASMIGVISPMAIGVIIGLTSWPWGARVYRAQTMSLRNREFVKSAETLGESKLRILFVEIMPNMLSMITSGFIGTIIYAIMAQSFIEFIGFGDRMSVTWGQMLNNAQSTGALSSGVWWEILGPSVFVILFGAGLTLINFSIDEVSNPKLRAQRIMRKYYKEKKKQEKLLNKQLSATTTSKGGIKYGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8D9</accession>
    <name>A0A174G8D9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopentomutase</fullName>
            <ecNumber evidence="4">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">deoB</name>
        <name evidence="6" type="ORF">ERS852471_01799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphopentomutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265796.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57160">
        <property type="protein sequence ID" value="CUO57160"/>
        <property type="gene ID" value="ERS852471_01799"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1772797at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="2"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO57160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="389" mass="43074" checksum="C1986E539BB33D0F" modified="2016-09-07" version="1">MKRAILVILDSLGVGELPDAKEYGDVGSHTLDNIYKVCGRLNINNLEELGIGNIEGVNGPNKCDSPKGSYGRAMELSKGKDTVTGHWEIGGVILDKPLNTYPEGFSDEIINEFLEKTNQKGILGNVVASGTEIIKELGAEHVKTGYPIIYTSADSVFQIAAHEEVISIEELYKMCEIAREMLVGDKAVGRVIARPFIGEEGNFTRTSNRRDYALNPFSKTMLEYLKENGKEVAAVGKIEDIYNKVGVTKAVHTKNNMDGVDKTLEYMKEVEEGLIFTNLVDFDMLYGHRNDAKGYGKAIEDFDGRLQEIYNNMSDDDMLIIAADHGCDPTTDSTDHSREYIPVLVYGKKLKGGVDLGTRKGFTDIGKTILDFFNIDNEIKGESFLDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GAP3</accession>
    <name>A0A174GAP3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Minicell-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">divIVA</name>
        <name evidence="7" type="ORF">ERS852471_01840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265875.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58961">
        <property type="protein sequence ID" value="CUO58961"/>
        <property type="gene ID" value="ERS852471_01840"/>
    </dbReference>
    <dbReference type="OrthoDB" id="875822at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO58961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="200" mass="23299" checksum="C80BDB2302D5FB45" modified="2016-09-07" version="1">MKLTPMDINNKEFKRGIRGYNPDEVDEFLDEVVENYEELYKENSRLKETVTRLKDKVDHYERLEATIQNTLLLAQNAAEQAKESSQKEADLIVNNANETAQKILDKAHSDVIGINDEYERVKEEFIKFRAKFRGFMNTQLQTFDELEKDLTKNYNVSEVIQELELGSKEIETKSNVNEESESNTVKDDDISEIKSFFAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCB3</accession>
    <name>A0A174GCB3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ftsL</name>
        <name evidence="2" type="ORF">ERS852471_01853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265900.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59541">
        <property type="protein sequence ID" value="CUO59541"/>
        <property type="gene ID" value="ERS852471_01853"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1852092at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="17859" checksum="A3422F4FCD9E0BC5" modified="2016-09-07" version="1">MVVREYDYIRGNTALAPERKIKEQEVKRKKKQVKKEFDWKNNRIKIISSAVIVSILGVASLTIDSYVYKIQKNLSNLEVEMDVELAKSEAMKVDLLKVSSLDNINNVAINGLNMTYPDKSSSITIDMSKNYFDHIKDKKETNTKTGLIAKIANWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU29</accession>
    <name>A0A174GU29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spsA_2</name>
        <name evidence="2" type="ORF">ERS852471_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64717">
        <property type="protein sequence ID" value="CUO64717"/>
        <property type="gene ID" value="ERS852471_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="273" mass="32115" checksum="A66AFE8D5B1BBBA0" modified="2016-09-07" version="1">MMVNNQKVSIIMGIYNCEDTLAESIESVVNQTYDNWELIMCDDCSRDKTYDIAQKYQEMYPNKIKVIKNERNITLGPTLNKCLKYASGEYVARHDGDDLYKKDKLEKQVKFLNQNRQYDLVGTGMNVFDENGFYGTRIPKEKPVSKDLMKGSTFAHATIMARDYVYIELNGYSEKNNRRGVEDYDLWFRFFKKGYIGYNLQEALYDVREDRGAYKRKNIKRRFNEIKTMLSGRALLGLDLKYSVYIIKPIITIITPKLLLRMYAERKMNKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVQ6</accession>
    <name>A0A174GVQ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
            <ecNumber evidence="2">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaD_2</name>
        <name evidence="2" type="ORF">ERS852471_01966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.212" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266100.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64930">
        <property type="protein sequence ID" value="CUO64930"/>
        <property type="gene ID" value="ERS852471_01966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="336" mass="39429" checksum="A1ACECDDBB3883C5" modified="2016-09-07" version="1">METKVSIVVPVYNAENYIAKCIDSILDSTLKEIEVILINDGSKDSSGKIIDEYVKKDSRIKVIHQKNSGPAVTRNKGIKIAKGNYVGFVDSDDTIEKNMFYELYNLANKKEVEVAMCGYNEINTRDNSKFIVTTNLENNKVYNKDEIKDNIIKTFTKSKNYGFFSLCNKIYLREWILDKNILMDEKRFHGEDWLFNINVFLNLNSFICTDKILYNYIHVNNESLMVKYRENQFDLFLDGRLKVLELIPNELIDYENFNRNFVIEFSSYILNTYKNVKDNKKRRELLKNVINNNEVLKASKEASGLPIHFKTTTFFIRNNMKWLALPTYKFMSMLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0I6</accession>
    <name>A0A174H0I6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266252.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68394">
        <property type="protein sequence ID" value="CUO68394"/>
        <property type="gene ID" value="ERS852471_02040"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="379" mass="42473" checksum="03681991E72CD2E9" modified="2016-09-07" version="1">MILISLVIKELLYFFRSKSNVATMFIFPAALIIIMGFSLNGLMNVDFNIFENKKVYYKVNNLSSGNEYLQVFKSFKDTCEESMKIEFEEVSDDIYGKNRVNSYEGLALIYINEDKYDFYRNEKKESRAQKIFRSVFDQYLERYSVINTVVSENPRVLNDMSEEKNIVVEEGISASGINSFTYYTFAELVLIILYISQITSVSVYNEGFENTFLRLKVSKAGDFSIILSKIILGVIVGILQVIIVYFISTVFLKIDWGINLMATMAVLTALIVFSSILGITVGCVFKDAKIAASVLNTLLIVFGFLGGAYLPISLIKSNEIASMLCKIAPSYWANIALLSLSSGIPSNYQTISVLLSLQLSAVLLIICIICSLRAGENNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0S4</accession>
    <name>A0A174H0S4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme B12-dependent glycerol dehydrogenase small subunit</fullName>
            <ecNumber evidence="1">4.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pduE</name>
        <name evidence="1" type="ORF">ERS852471_02009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.28" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266181.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66659">
        <property type="protein sequence ID" value="CUO66659"/>
        <property type="gene ID" value="ERS852471_02009"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735206at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050215">
        <property type="term" value="F:propanediol dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003207">
        <property type="entry name" value="Ppandiol/glycerol_DeHydtase_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036091">
        <property type="entry name" value="Prodiol/glycerol_DeHase__sf_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02287">
        <property type="entry name" value="Dehydratase_SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47148">
        <property type="entry name" value="SSF47148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="129" mass="14670" checksum="8A3436A26C0584C7" modified="2016-09-07" version="1">MKYPLSKSDIDIKSKSGKSIDQITIDEVVNGRVTGEDIKISKETLRLQGEIARQEGRTQLGENFERASELVDIPDEELLIIYNMLRPNRSTKEELLNKAKEIRDKYNAIACSNLIMDAVNVYSKRGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2C7</accession>
    <name>A0A174H2C7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase B</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">ERS852471_02059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266277.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69064">
        <property type="protein sequence ID" value="CUO69064"/>
        <property type="gene ID" value="ERS852471_02059"/>
    </dbReference>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO69064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="529" mass="60544" checksum="6BE1250A418BF8AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4R3</accession>
    <name>A0A174H4R3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rrf2-linked NADH-flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266218.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67785">
        <property type="protein sequence ID" value="CUO67785"/>
        <property type="gene ID" value="ERS852471_02023"/>
    </dbReference>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="23998" checksum="89AD2535A8152F64" modified="2016-09-07" version="1">MKLVVIGANGNLGSRVVKQALNRGHEVKSIAYMSNGNCEGTEVIDKNLFEMTQEDLGEAEIIISAFGGGFKADPVINKEAYEKYIELLDGTNKKIIAIAGAGSLYTDSTHSMREYEVPGYSETLAGISRNIKLGVDKIKERADLNWTAVCPSRKFDLEGPHTNNYIVGTDEEIIYNEDGNSYVTYEDLATAMLDIAEKDLYNRQVVTIATVTVKEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBD1</accession>
    <name>A0A174HBD1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">4.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbG</name>
        <name evidence="2" type="ORF">ERS852471_02124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.45" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266395.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72193">
        <property type="protein sequence ID" value="CUO72193"/>
        <property type="gene ID" value="ERS852471_02124"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047733">
        <property type="term" value="F:CDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="328" mass="36874" checksum="5130B15D89B81E2B" modified="2016-09-07" version="1">MVGTNDKFWKDKNIFITGGTGFLGSYLTKALVDYGANVTLLVRDDIPKSNLYSGDEYKSINVVRGSLEDYYLIERILGEYEIDTVFHLAAQAIVGVANRNPLGTFISNIQGTWNILEASRRSPLIRRVVVASSDKAYGDQEKLPYDESMPLQGKHPYDVSKSCADLIAQSYYETYKLPVCITRCGNLYGGGDLNFNRIIPQSIKSILKGEAPIIRSDGTFIRDYFYVEDAVEAYITLAEKIEEQNLGGQAFNFSNEIQLTVLELVDKILNIMGSELKPIILNIGSNEIKHQYLSAKKARDILGWNPKYTIEDGLAKTVKWYKEFLGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIE4</accession>
    <name>A0A174HIE4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase BglA</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bglA2_1</name>
        <name evidence="6" type="ORF">ERS852471_02145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266437.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72948">
        <property type="protein sequence ID" value="CUO72948"/>
        <property type="gene ID" value="ERS852471_02145"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO72948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="472" mass="54410" checksum="86AC523FD4DBBA2B" modified="2016-09-07" version="1">MSNNKFPDNFLWGGAVAANQCEGAWNVHGKGVSTADVATAGSREKKREYTDGVIEGKYYPSHEAIDFYHRFEGDIALLAEMGFKCFRTSIAWTRIFPNGDESEPNEEGLKYYDRLFDECLKYGIEPVVTISHYEMPYALVEKYGAWRNRKLVDFYVNYCEAIFSRYKNKVKYWMTFNEINVIALHPFIPAGIKFVEGENKEQVVYQAAHHQLVASAKAVSLGHKINPDFKIGMMMIYPLMYPETCNPSDTLLVQEAMNKNYFFSDVQARGYYPNYMKNYFERNNITIEMAEDDEEVLREGSVDYIGFSYYMSLVMGTNKDEESVSGNMMGGKKNPYLQASDWGWQIDPVGLRISLNNLYNRYQKPLFIVENGLGAIDAVEEDGSINDDYRIDYLRKHIEEMKKAVVIDGVELMGYTPWGCIDLISASTGEMMKRYGFIYVDKNNDGEGTLDRKRKKSFYWYKDVIRSNGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKR7</accession>
    <name>A0A174HKR7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase [glutamine-hydrolyzing] 3</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnO</name>
        <name evidence="9" type="ORF">ERS852471_02167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266478.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73758">
        <property type="protein sequence ID" value="CUO73758"/>
        <property type="gene ID" value="ERS852471_02167"/>
    </dbReference>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="376"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO73758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="613" mass="70180" checksum="D7D3E197860F051F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRU1</accession>
    <name>A0A174HRU1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">algA_3</name>
        <name evidence="2" type="ORF">ERS852471_02259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266633.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76941">
        <property type="protein sequence ID" value="CUO76941"/>
        <property type="gene ID" value="ERS852471_02259"/>
    </dbReference>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="355" mass="40385" checksum="C7489DD369A86907" modified="2016-09-07" version="1">MIYALVLAGGKGTRLYPLSRTNQPKQFLKLINGKSFLVNTVERITPLISKENIYVVTNQDYVDKIKNELSDINPDNIFTEPQNKETATCIGLSAVKLLKKDKDAIMVVLPSDHHVEGKKEYLDVLSEAIDIANKRRGIVTVGITPTRPETGYGYIEMGERIVSSEAAYKIARFTEKPNIEVAKDFLLKGTYLWNSGMFIFRADVILREIEKYLPKMYKSLMEIYQNIGEEFEEQVVREQYNLIDGISIDFGVMQRTRKAYVIKGNFAWDDIGSFTALSRFLTQNNSNNISKNVYVQDCENCSIFGDKNLIIGFGVKDLVVVDAGDVILVMDKNKDQEIKHLLNDLNTNEQFDDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I2B6</accession>
    <name>A0A174I2B6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dnaN</name>
        <name evidence="15" type="ORF">ERS852471_02375</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO81324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266816.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO81324">
        <property type="protein sequence ID" value="CUO81324"/>
        <property type="gene ID" value="ERS852471_02375"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="128"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="366" mass="40759" checksum="0024C18D9065DFE1" modified="2016-09-07" version="1">MNIICSKQKLQEGISIVTKAITGKTTMPVLEGIYIEATKTGLTLIGSDMDVSIETKVEADVLQEGKIVIDAKIFSEIIRKLPNSDVKIEVVENDRIQIACEKSLFNVVFMNQADYPALPTINEDITVEVPQNILKNMIKGTSFAIAQDEARPILQGILFEVKDKHLNLVALDGYRLAVRTELLNIDDSIEVVIPGKTFNEVAKILEDNNDIVQITFTNNHILFNLNNTKIISRLLDGKFVNYASLLPPEYKLLVNVNKQEFQNGLERASLMAKDGNSNLIKLDIQDESVIISSNSQLGKVREEVAINLQGEGIEIAFNSRYILDVLKTMEDENVILEMSSAVSPCVIRGSETNNAKYLVLPVRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4V3</accession>
    <name>A0A174I4V3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266836.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82194">
        <property type="protein sequence ID" value="CUO82194"/>
        <property type="gene ID" value="ERS852471_02384"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="530" mass="61808" checksum="427D762C9D559667" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4Y2</accession>
    <name>A0A174I4Y2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacterial protein of uncharacterized function (DUF951)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266784.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80647">
        <property type="protein sequence ID" value="CUO80647"/>
        <property type="gene ID" value="ERS852471_02357"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2041238at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037263">
        <property type="entry name" value="DUF951_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO80647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7322" checksum="B5F83E8FD2F9C339" modified="2016-09-07" version="1">MIETFELGDIVEMKKEHPCGNKNFEIIRVGADVKIKCTECGRIIMLPRRKFQKDAKKVVKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I7D0</accession>
    <name>A0A174I7D0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gidB</name>
        <name evidence="2" type="synonym">rsmG</name>
        <name evidence="3" type="ORF">ERS852471_02366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266800.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80979">
        <property type="protein sequence ID" value="CUO80979"/>
        <property type="gene ID" value="ERS852471_02366"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO80979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="26790" checksum="F31FACC79CCCF00A" modified="2016-09-07" version="1">MEFFDLMSTAAKDVGIELTKEQYEKFIKYMRLVQEWNEKINLTAITEDNEFVKKHFIDCIKAFKSNAIKEAKTLIDVGTGAGFPGLPIAILSPETKVTLLDSLNKRINFLNTVVRELDLKNVTTIHSRAEDGARNPELREQFDVATSRAVANMAVLSEFCMPFVKKNGYFVALKGPSIEEELENGANAIKTLGGELKNIIEVEVEGTDLNHNIVEVLKVNKCPKTYPRKAGTINKKPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I7K7</accession>
    <name>A0A174I7K7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjaB</name>
        <name evidence="2" type="ORF">ERS852471_02409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266876.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83172">
        <property type="protein sequence ID" value="CUO83172"/>
        <property type="gene ID" value="ERS852471_02409"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16862" checksum="D73A09D31826BEFE" modified="2016-09-07" version="1">MIKEFNINQLDEVMKIWLEVNEDAHSFISKEYWNNNYELVKSLLPDANIYVFEEDNIIKGFIGIIEDGYIAGIFIKNEYQREGIGHKLIEYSKSKYKELSLNVYAKNENALNFYYKNNFKVLGSKINEETNELEYTMVYKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBP2</accession>
    <name>A0A174IBP2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybbH_4</name>
        <name evidence="4" type="ORF">ERS852471_02389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266844.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82379">
        <property type="protein sequence ID" value="CUO82379"/>
        <property type="gene ID" value="ERS852471_02389"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="278" mass="31790" checksum="733D44DF0BC1C401" modified="2016-09-07" version="1">MSIIERLKSQDDLTPVECELVRYILENQDKIINLNISDLAAITFTSNATIVRLCRKIGLSGYRQFKVQFIKEVEKRRKEKSDVDINHPFGEKESEEEIIKRIADLSKEAIDTCYESIDSLAISKVAKYIINANSTYIYANGDSLISSIGFANRLSKLKINTVIANQYGEISTNTYNVTRDDVALFVSYSGKNLIQDRYMRVLKRSGCKILIITADKNISGYDGTIIFPNREAVEGKIATYYSQIAINYILNCIYAIIFASDFRKNYNKKYKIEKLEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IIL5</accession>
    <name>A0A174IIL5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ORF">ERS852471_02501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117032.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87172">
        <property type="protein sequence ID" value="CUO87172"/>
        <property type="gene ID" value="ERS852471_02501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO87172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="70" mass="8279" checksum="9BCA090D65034F88" modified="2016-09-07" version="1">MKARELKELRANNPQDLKVKLNDLKAELFNLRFQLATGQLENPMRIKEVKKSIAQIKTIIREEEIRAFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IJL4</accession>
    <name>A0A174IJL4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="11" type="ORF">ERS852471_02510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117040.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87532">
        <property type="protein sequence ID" value="CUO87532"/>
        <property type="gene ID" value="ERS852471_02510"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO87532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="165" mass="17401" checksum="2960D53FF19B023B" modified="2016-09-07" version="1">MRIDPSTLDLKEKVVFINRVTKVVKGGRNFRFSALVVVGDENGHVGVGMGKSIEIPEAIKKGIEDAKKNMVSVAIVGTTVPHEIYGKFGTGKVLIMPAKEGTGVIAGGPARAVLELAGLKDVRAKSLGSNNPRNMVNATINGLASLRTAEDIAKLRGKTVEEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IRA5</accession>
    <name>A0A174IRA5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267120.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89884">
        <property type="protein sequence ID" value="CUO89884"/>
        <property type="gene ID" value="ERS852471_02553"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1817816at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO89884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="25690" checksum="86A5EDD7640A4622" modified="2016-09-07" version="1">MKNTRVSIIIVILVIIIISIFGCSYFNKSVESKNENIKNEEVDNSNTDDIEGVIEFLSAISGVKAIDIEIINNPVGFKGKLFVPKESIANGVDYYLQHTNNEKMEDLKVDIGENFISVYVNYKVNKVIKTPIEVRINPVLNENKDLVINIDEVKFLDIKVADWIVNLALNSFVKDWFPSDSGLSLEFNNGNVVVYKENFNGVNLNQLSIEENGLNIDATIGIEKIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IUD2</accession>
    <name>A0A174IUD2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267131.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90061">
        <property type="protein sequence ID" value="CUO90061"/>
        <property type="gene ID" value="ERS852471_02558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="23951" checksum="815423B0F33CCD41" modified="2016-09-07" version="1">MFNMKGKKSLLPTVLLALFLMEVFANGVNSIIGIVIYCAMIVSFIGGEIVERLRNKKGVEIRNKNIIAESRNGDYYLGIFVCLAIVTVYIVICAFIKSSSGMFVSINLSDNPIIIIGLVILLIAYGYFYFTSKQVIYAEGIVLANNKFISSSDFVDIAFRETLIRKKKLIEITIKDDILSYTNTIRIKCKDEEEFEKVVVLITRVTGIFAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IUT7</accession>
    <name>A0A174IUT7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO89108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267109.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89108">
        <property type="protein sequence ID" value="CUO89108"/>
        <property type="gene ID" value="ERS852471_02547"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856786at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024629" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO89108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="14876" checksum="112D6C06135BBDF3" modified="2016-09-07" version="1">MKKKVIAVTLLAAMALTGCGSKGFTGEKVGEIEDSKGNVTMATVQFENGKAVAVDIDVKQADGSMKSEASKSGAYDMKNEPGKKWHEQADLLEEFIVANDFDLSKVTLTNDEGNTDAVSGVTIKVKGYLDAVEDALKQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6Z1</accession>
    <name>A0A174J6Z1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">clpB</name>
        <name evidence="12" type="ORF">ERS852471_02623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO92935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267251.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92935">
        <property type="protein sequence ID" value="CUO92935"/>
        <property type="gene ID" value="ERS852471_02623"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="410"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO92935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="866" mass="97653" checksum="1E773C8B71AF930F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBS6</accession>
    <name>A0A174JBS6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaJ_1</name>
        <name evidence="6" type="synonym">dnaJ</name>
        <name evidence="10" type="ORF">ERS852471_02716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267417.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97103">
        <property type="protein sequence ID" value="CUO97103"/>
        <property type="gene ID" value="ERS852471_02716"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="195"/>
        </location>
        <ligand>
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            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="209"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO97103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="376" mass="40622" checksum="526F9CAFB0D24FFF" modified="2016-09-07" version="1">MASKDYYASLGLEKGASDDEIKRAFRKLAIKYHPDKNQGNKEAEEKFKEINEAYQVLSDPEKKARYDQFGTADFDGSGFGSGGFGGFDFSDMGGFGDIFESFFGGGGGSSRRRNGPTKGADIEYTLNLTFEEAIFGTEKEITITKNENCEECHGTGAKAGSTPKTCDQCGGSGQVRVQRQTPLGNFVSTSTCDRCGGKGTIVDNPCPTCSGKGKVRKRRVIKVKVPAGVDTGNIIPLRGQGEHGNNGGPAGDLYVRINVSASKQFERRGNDIYIDTHISMSKAALGVEIIVPTVDGDVKYTIPEGTQSGTLFRLKGKGVPRVNSSGRGDQYVRVIVDIPKNLNEKQKDALKAFMEACGESIDGEVKHKKGFKDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCM9</accession>
    <name>A0A174JCM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell shape-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267358.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95378">
        <property type="protein sequence ID" value="CUO95378"/>
        <property type="gene ID" value="ERS852471_02685"/>
    </dbReference>
    <dbReference type="OrthoDB" id="237152at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO95378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="546" mass="60675" checksum="54BA08C538C7C757" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JD64</accession>
    <name>A0A174JD64_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ntpD</name>
        <name evidence="4" type="synonym">atpD</name>
        <name evidence="5" type="ORF">ERS852471_02677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO95060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267343.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95060">
        <property type="protein sequence ID" value="CUO95060"/>
        <property type="gene ID" value="ERS852471_02677"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1334900at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO95060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="213" mass="24665" checksum="DCAFDFA62A6F81DC" modified="2016-09-07" version="1">MARLNVNPTRMELTKLKKRLTTATRGHKLLKDKQDELMRQFINLVKYNNELRKSVEKELEGSFKDFVMASAVMSSEFLEEAVAYPKESISVEVGTKNIMSVNVPEMTFRRQLQDDEGSIFPYGFANTSSELDDAITKLYTILPKLLELAEVEKSTQLMADEIEKTRRRVNALEYMTIPQLQETIKYIRMKLDENERGALTRLMKVKDMIQSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JHJ8</accession>
    <name>A0A174JHJ8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mglB</name>
        <name evidence="9" type="ORF">ERS852471_02761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267496.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99182">
        <property type="protein sequence ID" value="CUO99182"/>
        <property type="gene ID" value="ERS852471_02761"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="8">
        <location>
            <begin position="38"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO99182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="38485" checksum="131A740AB5F3390B" modified="2016-09-07" version="1">MGKMRGCSTFAAIIFIFNYLVGCTNNSEIYNDIDEIKIGVTVYKEDDKFISTITNNILELAKKKEIEENVKITVDILDAKSNLANQCNQVDKFILNDYDVICVNIVDRTSAATIIDKAKNSNTPIIFFNREPVEEDMRRWNEVYYVGAEAEQSGELQGNLIIDKYYMDKDSVDKNGDGKIQYVMLEGEHGHQDTAIRTEYSIKTIVQSGIEVEKLADDTANWEFAQAKSKMTGWIKEFGSEIEVVFSNNDDMALGAVDALNDAKIYDVIVVGVDGVKEALQAVKNEEILGTVISNSMAQAEGIFNIAYLKAINGDLSNVDGLEGKYIKTKHIKVDKENVDLYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JII4</accession>
    <name>A0A174JII4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YqfC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqfC</name>
        <name evidence="1" type="ORF">ERS852471_02725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267434.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97428">
        <property type="protein sequence ID" value="CUO97428"/>
        <property type="gene ID" value="ERS852471_02725"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019102at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022477">
        <property type="entry name" value="Spore_YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038705">
        <property type="entry name" value="YabP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02856">
        <property type="entry name" value="spore_yqfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO97428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10273" checksum="8E2469DBD9356E65" modified="2016-09-07" version="1">MGEKLNKKRTILIEKLDLPKDVVLDVPKIIVIGKEEVTIENHKGILTFNEDEIRVNSKLGPISIKGEGFEILYIATSTITISGKFASISYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JKE7</accession>
    <name>A0A174JKE7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cdd_2</name>
        <name evidence="13" type="ORF">ERS852471_02730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267444.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97645">
        <property type="protein sequence ID" value="CUO97645"/>
        <property type="gene ID" value="ERS852471_02730"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO97645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="14696" checksum="2E519D6F5E0E4022" modified="2016-09-07" version="1">MDYKEIVKKALEAREKAYCPYSNFKVGAAVLFEDGNIYTGCNIENASFGGTNCAERTAIFKGVYEGNREIKAIAVVGDTNAYTYPCGICRQVIAEFVVDTSIPVIIIKNENDYLVKTFDEILPGIFSKKDLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JP24</accession>
    <name>A0A174JP24_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="4">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mglA_2</name>
        <name evidence="6" type="ORF">ERS852471_02755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO98920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267488.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98920">
        <property type="protein sequence ID" value="CUO98920"/>
        <property type="gene ID" value="ERS852471_02755"/>
    </dbReference>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="253"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO98920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="498" mass="55346" checksum="E2DD451FD4C883F4" modified="2016-09-07" version="1">MAESKYILEMIDINKSFPGVKALDNANLKVKEGSVHALMGENGAGKSTLMKCLFGIYIEDSGEIYVDGKKVKFSNPKQAMDNGVAMVHQELNQVLQRDVMDNIWLGRYPGGKGIVDSKKMFEETEKVFKELEIDVNPKTKMAKLSVSQRQMVEIAKAVSYNAKILVLDEPTSSLTQEEVTHLFKIINKLRDRGCGIIYISHKMEEILEISDDVTIMRDGKWIATEEAKDLTTDKIIKLMVGRDLTNRFPPKTNKPSDVILEVKNLTGKYEPAVKDISFELKKGEILGIAGLVGSRRTELLETIFGIRHHSSGELILHGKKVENKDSRVAINNGFALLTEERRATGIFGGLDIKFNTIIASIDNYSKGMLNEKKMVEDTKWVIDSMKVKTPSQKTPIKSLSGGNQQKVIIGRWLLTNPEVLLLDEPTRGIDVGAKYEIYQLIIDLANKGKGVIVVSSEMPELLGICDRILVMSNGRIAGAGTPDELSQEAIMESAAKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQF4</accession>
    <name>A0A174JQF4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pfkA</name>
        <name evidence="17" type="ORF">ERS852471_02817</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02003">
        <property type="protein sequence ID" value="CUP02003"/>
        <property type="gene ID" value="ERS852471_02817"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="5"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="23"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP02003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="321" mass="34328" checksum="222FD0C2600FC301" modified="2016-09-07" version="1">MSIKKIAVLTSGGDAPGMNAAIRAVVRTALHHGLEVVGVQRGYAGLINGELFEMDRSSVSDIIHRGGTILRTARCLEFKQEEVRKEAAELLAKNGVDALVVIGGDGSFMGAKLLSKLGVKTIGLPGTIDNDLSYTDYTIGFDTALNTVIEGVDKIRDTSSSHERVSIVEVMGRNCGDLALYAGVACGAEYTITPEKGFDKDELCNVIKQGKEVGKIHNLVLLAEGIGGAYDLAKYVEAQTGIETRATILGHIQRGGSPSAFDRVLASRMGSKAVEVLLEGKTSRVIGIKENQIFDQDIDEALALGRKFDDKLFSISEEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JZK0</accession>
    <name>A0A174JZK0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fdx</name>
        <name evidence="6" type="ORF">ERS852471_02888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267734.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05263">
        <property type="protein sequence ID" value="CUP05263"/>
        <property type="gene ID" value="ERS852471_02888"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP05263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="6473" checksum="0D5895349EA43F0E" modified="2016-09-07" version="1">MRAFVDENTCISCGLCEGLCSDVFSLDTGVAVAIEGEVESGLEDSVREACDGCPVQAISIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K168</accession>
    <name>A0A174K168_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin bcp</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp</name>
        <name evidence="5" type="ORF">ERS852471_02856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267673.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03757">
        <property type="protein sequence ID" value="CUP03757"/>
        <property type="gene ID" value="ERS852471_02856"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP03757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="17529" checksum="1E0A761196379E8E" modified="2016-09-07" version="1">MIEINSIVPNFSLIGSDKKEHSLSDYKGKKIILYFYPRDNTPGCSTEACDFRDNNSIIEDMNAIVIGVSRDSLKSHDKFIEKFNLPFLLLSDEDETLCNLFGVIKEKNMYGKKVMGIERSTFIINEDGVLVKEYRKVKVKGHIDTILKDLKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K3F2</accession>
    <name>A0A174K3F2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ecsA_2</name>
        <name evidence="5" type="ORF">ERS852471_02863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267687.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04358">
        <property type="protein sequence ID" value="CUP04358"/>
        <property type="gene ID" value="ERS852471_02863"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP04358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="237" mass="26168" checksum="452E975D0A8D950E" modified="2016-09-07" version="1">MLEIKNFSKAYKQGKKAVDNISLTINSGDIFGFIGHNGAGKTTTIKSVVGILEFTEGEILIDGLSIKDKPIECKRIMAYIPDNPDLYEALTGIQYLSFISDIYGVSKSQREELIKKYADKLELTRFLGDLIGSYSHGMKQKLAVISALIHKPKLLVLDEPFVGLDPKAAHTLKEIMKEICLEGSAIFFSTHVLEVAEKLCNRVAIIKDGKIVAQGNTDEVRGNSSLEDIFMGLIDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5G4</accession>
    <name>A0A174K5G4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP06081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267774.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06081">
        <property type="protein sequence ID" value="CUP06081"/>
        <property type="gene ID" value="ERS852471_02912"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2154085at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP06081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="153" mass="17557" checksum="2B7129107008BC7A" modified="2016-09-07" version="1">MRDQIEMTRGVFYSLVGICALIIFSISLEAIFKVKDTAFFDMWLSNPNLNTAMIGETSEELYQTYLTMCMSSFFVKIITPIGLAIHSYITLTKLRVNKLYVVIWTVLLIGSFGFSIIGESWYSMFFIVSSIGYIALILMMIYLGKCIYNVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9G6</accession>
    <name>A0A174K9G6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme oxygenase</fullName>
            <ecNumber evidence="3">1.14.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbsA1</name>
        <name evidence="3" type="ORF">ERS852471_02927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.99.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267803.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07046">
        <property type="protein sequence ID" value="CUP07046"/>
        <property type="gene ID" value="ERS852471_02927"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1371367at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="208" mass="23978" checksum="64830754E1A48148" modified="2016-09-07" version="1">MKFMMDIKEKTSLLHSAAENTGYIKKLMDGTASVEGYAEYIFNLERMYRAIEVALDKNENNEIVKPFVTKELYRSELMRKDLEFLLGDKLDSMKLLASTEACVAKIEELSEKSPELVVAYAYTRFLADLFGGRTFLSLLSTSYNISAEGLNYYRFPEITDLRGYVMKYHKMLADINLTEEKKIDFINEVNNAYIYNLAISNELDAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KDT7</accession>
    <name>A0A174KDT7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">feuB_2</name>
        <name evidence="8" type="ORF">ERS852471_02937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267821.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07460">
        <property type="protein sequence ID" value="CUP07460"/>
        <property type="gene ID" value="ERS852471_02937"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP07460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="35375" checksum="9FF71382ADB63A0B" modified="2016-09-07" version="1">MEQSKKRTIIFVICSLLLLVGGLVLAVRLGSVHITFTDIFDSIFNYSETLEKMLVRDVRIPRALSVLLTGGILGVTGAMIQGVTRNPIAEPSILGVSQGATLVIAIFYAAGIAITTTNVMIASFIGALITGIIVLGFISKKANNNSIAKILLAGTAMSTFFISLTTVIGLLSNQSQMIGFWVSGGFRNASWADFRLVFFVGIIGLIIACVLSPKINILNLGDDVAIGLGQNPEKIRFMTLMVMIPMCAAAVAVGKNIAFVGLIVPQIVRKLLGEDYRRNIPCSFLLGAVLLTYADIAARMLFNPYETPIGVFTALIGIPFFIAIARKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KVG0</accession>
    <name>A0A174KVG0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="3">1.3.99.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hemZ_2</name>
        <name evidence="3" type="ORF">ERS852471_03114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.22" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP16043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268158.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16043">
        <property type="protein sequence ID" value="CUP16043"/>
        <property type="gene ID" value="ERS852471_03114"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023995">
        <property type="entry name" value="HemZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF1">
        <property type="entry name" value="PTHR13932:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00310">
        <property type="entry name" value="oxygen-independent_coproporphy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03994">
        <property type="entry name" value="rSAM_HemZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="140"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP16043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="474" mass="55110" checksum="4195754ABBC99408" modified="2016-09-07" version="1">MEIKIKLNDLKYRYDVYQMFNIYFSLDEIKFEDDGEYVVEVLEDEVKFSYKDFNKSVKIGEKIKEDIKRLVFMSLKELTNEEYPWGILVGIRPSKIALKYLEEGKSEEEIIKIFKEKHLASEEKAKLCIEVAKTEEKFVNDDEKKISIYIGMAFCPTRCFYCSFTANSILGSKKLVNPYLEALTYEIRKISEYVEERNLKIETVYFGGGTPTAVNNEEFENIMKEVYNAFVKNKKILEFTVECGRPDSITVEKLQTMKNYNVTRISINPQTMNDDTLKAIGRGHNVNDVKEKFNLARQMGFNDINMDIIIGLPGEGLDYVKTTCNEIYNLKPDSLTVHGLSLKRASILYENFILKKGIQVKKQEELASMYNESMELAKKLGLKPYYMYRQKNMVGNMENLGYSKEGNECIYNIQMIEDKQTIIALGADAVTKVVFLEEDRIERFGNIKDIKEYSNRIEEMVNGKINLLDTLYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L8I3</accession>
    <name>A0A174L8I3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18996">
        <property type="protein sequence ID" value="CUP18996"/>
        <property type="gene ID" value="ERS852471_03171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="37" mass="4178" checksum="38CF619ED24EDDC9" modified="2016-09-07" version="1">MSSNNNSNEVIDLLSEIIINFISKMTSTSNTDKFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LD56</accession>
    <name>A0A174LD56_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268279.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20068">
        <property type="protein sequence ID" value="CUP20068"/>
        <property type="gene ID" value="ERS852471_03187"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2032789at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027890">
        <property type="entry name" value="DUF4491"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14898">
        <property type="entry name" value="DUF4491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP20068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10489" checksum="A043E389D8383F2C" modified="2016-09-07" version="1">MNFDGIIIGLVSFLIIGLFHPIVIKGEYHFSKNIWPIFLVVGIVFLAISLYIDNSILTASLGVTGFSCLWSIKELFEQEERVKKGWYPKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LE89</accession>
    <name>A0A174LE89_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanolamine/propanediol utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pduU</name>
        <name evidence="3" type="ORF">ERS852471_03184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19910">
        <property type="protein sequence ID" value="CUP19910"/>
        <property type="gene ID" value="ERS852471_03184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07046">
        <property type="entry name" value="BMC_PduU-EutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009307">
        <property type="entry name" value="EutS/PduU/CutR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40449">
        <property type="entry name" value="PTHR40449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012296">
        <property type="entry name" value="EutS_PduU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="2">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="12898" checksum="2D003B986DE500B9" modified="2016-09-07" version="1">MDNIFEKSETTRIIQEFVPGKQVTLAHVIANPVPELYQKLGLVTNQKGAIGIMTITPSEGTIIAADIATKASDVSIGFIDRFSGSLVIVGSVSSVEESLREVMKVLGDMLKFTATNITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LEG3</accession>
    <name>A0A174LEG3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19879">
        <property type="protein sequence ID" value="CUP19879"/>
        <property type="gene ID" value="ERS852471_03183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011238">
        <property type="entry name" value="Organelle_shell_prot_PduT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034834">
        <property type="entry name" value="PduT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP19879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="182" mass="19165" checksum="B44D9808BA4E6AD8" modified="2016-09-07" version="1">MVSALGLVEYLKIPTGMMAADKMSKTSNIDIIHAATVCPGKYIVLFKGNLSDVKAAIEGGTIGFEHNVIDSFLLGNPTEQIYGAISGSTSVEIKGAVGIVESYSVASIIEAADIAAKTSAVTLVEVRLARGMCGKSFFIINGELSAVEMSVENAKKHLMESGMLLDSAVIANPSDNFIENLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHL6</accession>
    <name>A0A174LHL6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplL</name>
        <name evidence="7" type="ORF">ERS852471_03229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268356.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22371">
        <property type="protein sequence ID" value="CUP22371"/>
        <property type="gene ID" value="ERS852471_03229"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP22371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="121" mass="12607" checksum="DB32DA36FF14CFEC" modified="2016-09-07" version="1">MTREDIIQAIKEMTVLELNELVTACEEEFGVSAAAPVAVAGAVAGGAAAEEKTEFDVVLTNAGANKIKVIKVVRELTGLGLKEAKEIVDGAPKTLKEAVAKEAAEEMKAKLAEVGAEVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LMB9</accession>
    <name>A0A174LMB9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransbutyrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268444.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25434">
        <property type="protein sequence ID" value="CUP25434"/>
        <property type="gene ID" value="ERS852471_03281"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2074871at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP25434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="18038" checksum="1AA22CC81DDA165F" modified="2016-09-07" version="1">MRNRRLIIRWIALLFWMGLIFYMSNQPGDVSSKQSGLVLKLFQFIGIDLNNELSELATFIVRKTAHFTEYFILYFLSINVMKCYLNIKNAIFYSFIFSFFYACTDEIHQYFIPGRAMAFRDVLIDSAGALLAMIIVNIKIKINKKKENKLNASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGM5</accession>
    <name>A0A173XGM5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_1</name>
        <name evidence="6" type="ORF">ERS852471_00022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262694.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50007">
        <property type="protein sequence ID" value="CUN50007"/>
        <property type="gene ID" value="ERS852471_00022"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN50007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="341" mass="38243" checksum="27FA117E3D501A72" modified="2016-09-07" version="1">MDTVLEVKNLKVNFKTKYGEVKAVRDVSFDLKKGEILTIVGESGCGKSVLCRSILKLLPENGYVKSGHILLNGNNICNLTDKMMSKIRGKEISMIFQDPMTSLNPTMSIGKQISEAVRVHNKVTRKEAKKRAIELIDFVGIDEAESRYNQYPYEFSGGMRQRIAIAIALACNPKVLIADEPTTALDSIMQNKILDLIKSIQMKTNISIIFITHDMEVVNRISDRIAVMYAGKIVEIGKKEEIFLNAVHPYTIGLMSSIAAFNMDKEYLPTIEGMPPSLLNPPKGDAFALRNKNPLVIDFLEEPPMFKVSESHYAATWLLHPKAAIAREEIRAKEEKLDINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLR0</accession>
    <name>A0A173XLR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tetD_1</name>
        <name evidence="2" type="ORF">ERS852471_00051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN51886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51886">
        <property type="protein sequence ID" value="CUN51886"/>
        <property type="gene ID" value="ERS852471_00051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="367" mass="43191" checksum="AB05619BC561148C" modified="2016-09-07" version="1">MQKNNIEEIIDYIEDNLSNDISLTDIATRVNYSPFYCSTSFRKYIGISIKKYILKRRLQCAADDLCLTKLRIIDIAYKYCYSSQEAFSRAFLSCYGISPYEYRKNKLPASQFNSKITYNNESDNQGDVMKNEIINTIQEEIYSKYESNVLHILNGSCMMDEFKKKKWCNENFTYVSFNEAMCWGEADEEIFSQAFIEKRVQSLNGTIEQYRDIVLNPLEPLFKNEFDTIVLWFGDDMFCQMNMLTILAYLEQSNFDGDVLFCMAIESSDEMLPNAYEIDINGSYQRYKSIICNKQMPNEKLMPGLYQATLLYLNYLNKDSEINRYIIEHINKSEKQLINELFSNFPQYGLGDLQYKMLIKNINKTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXA1</accession>
    <name>A0A173XXA1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yjeM</name>
        <name evidence="6" type="ORF">ERS852471_00140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262907.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56073">
        <property type="protein sequence ID" value="CUN56073"/>
        <property type="gene ID" value="ERS852471_00140"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN56073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="505" mass="55286" checksum="50EB287C700A32BD" modified="2016-09-07" version="1">MGSKKSTSKLTLMALILMIFTSVFGFNNIPRAFYLMGYSAIPWYIFGAIAFFIPYAFMMAEFGAAYKDEKGGIYSWMESSVGRKFAFIGTFMWFSSYIVWMVSVSSSIWVPLSNLIFGADKTSTWSLFGLNSAQTLGILGICFIIVITFLSSKGMNSISKVASVGGAFVTSANVVLIVGSIIVLCANKFKFAQPITLEQFTHSPNPAYGSILGVLGFLVFAIFAYGGLEAVGGLVDQTENSQVTFPKGIKISAIVIGVGYSLAILTVGFFTNWDAVLNNPNVTMANVSYVVIKNLGVELGKVFGLSPNGIEIMGTWFARYIGLAMFLALLGAFFTLIYAPLKQLIEGAPKGIWPKSWTELDKNGMPVKAMYVQGIAVIAIILIASFGGRNSDKFLDYLILMGNVSMTIPTMFLAIAFIYFKKNDNIKKPFVIFKSKTMATVWAIIVTITVGFANFFTIIQPAIETKDYVSTIFQLAGPIVFGLIAFILISNFERKEKNKDKKRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ46</accession>
    <name>A0A173XZ46_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate uptake ABC transporter carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lacE</name>
        <name evidence="2" type="ORF">ERS852471_00149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262920.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56540">
        <property type="protein sequence ID" value="CUN56540"/>
        <property type="gene ID" value="ERS852471_00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015787" evidence="1">
        <location>
            <begin position="26"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="442" mass="48422" checksum="DF7817001861EA15" modified="2016-09-07" version="1">MKKRLLAVLMTAAVATSAFVGCSKGASSNADIVTELQEPVTIEMWHYMTGKQAETLQEIVEEFNTTNDKGITVNAVAQGSVADLNKKVIAASQSNTLPAIINVYPDLATGLINEGKIVDLATYINDENVGMADDMKNDFVDAFIAELSQWEEGKVYGLPMTKSTEVLYVNKTLLEKLGYTMADMENLTMEKLAEISKKAYDELGIAGFGFDSSSNAYISTLKMGGMNFVELDGTINVDNEWVREFMPFLQEQTTKGYFRIAGEDKFLSGPFSNQKMLTYQGSSAGFAHINTNGAFEIGVVEVPVFEGKDKAVIQQGASLFATSTVSAEQQYASYEFMKFLTSAENTAKFATSTGYLPVRKSAQDLDSVKALIEDETNLYGQIYNVAQKALEYAYYTPAVNNAQSARTSVEEKYAAFVTGNITDLDTFVKDLLSEVETSISRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3G0</accession>
    <name>A0A173Y3G0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262956.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57465">
        <property type="protein sequence ID" value="CUN57465"/>
        <property type="gene ID" value="ERS852471_00168"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2127119at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015876" evidence="1">
        <location>
            <begin position="31"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="265" mass="29999" checksum="56E6EC8ED9F26621" modified="2016-09-07" version="1">MFKGKRFLKILLVAGLASLSLVGCGTKAEVEPVRLGTPEELVETFIKDNEEKNVSEMVKLYSDVYVDSTGYDLSTIEKILEKSKKEYEIVNSELVSMEDYSDTIKRATIKITSKANEEETTADYEYALIKEEDGWAISPDGIIACENFDIPMYNKGELTLNLAKNIKLFEGGILRVKVYNDSKNKFMFGSEANKCEIIVETSTGKYVTTMDEPTMLDKKVNSYFLARITELDGEINKVTVTNIYELDKDENIIEDSKKDIIAYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6I1</accession>
    <name>A0A173Y6I1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aluminum resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN58837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263010.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58837">
        <property type="protein sequence ID" value="CUN58837"/>
        <property type="gene ID" value="ERS852471_00195"/>
    </dbReference>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009651">
        <property type="entry name" value="Met_g_lyase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46658">
        <property type="entry name" value="PTHR46658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06838">
        <property type="entry name" value="Met_gamma_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="425" mass="47237" checksum="EBE977BE2F7E8E6C" modified="2016-09-07" version="1">MLNLTEEFLKKQYKINDETFTLYNKALRDVEEEFKIYDEIREFNQLKVLNALQEERISESHFTNSSGYGYGDIGRDSLDKVYAKVFNTESALVRPHFVNGTHAIACAIIGNLRPNDTMVCISGKPYDTLHNIIGIGEEKNIGSLKEYGVNYKQVDLIDGKFDEDKIITLLKEDKSIRLVHIQRSTGYGWRNSFLVSELGDIIAKVKSIRNDVIVFVDNCYGEFIDTIEPTDVGADLIAGSLIKNIGGGIAPTGGYIAGKEEYVLQASYRLTTPGIGGECGSTFGVMRQFYQGLFLAPHIAMEAVKGAVFCARIMELAGFEVLPKYNEKRSDIIQAIKFNDKDKLINFCKGIQKASPIDSFVECEPWDMPGYSDQVIMAAGAFIQGSSIELSADAPIREPYIAYLQGGLTFDHAKIGVLFALSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YC48</accession>
    <name>A0A173YC48_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA modification methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN60328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263055.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60328">
        <property type="protein sequence ID" value="CUN60328"/>
        <property type="gene ID" value="ERS852471_00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="154"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="312" mass="36280" checksum="8C1591880D226C3C" modified="2016-09-07" version="1">MIKEYLYIINYQDYEKSLCDMEMKYIFGNVPKEKYIYSKVNIKPSRSAFIKHKISIIYSSIDIDNIVEHIRDNKIAYNDFKVNYIKSDYDDIDYNQRLQAVKEIGFVIIGFPDIHNPKVNLAITKINNNYIFGEYEKNDLSWQRFDKMPHSYSNGLSLKMARAIINIAVQNNLDSKVIDPCCGIGTVVLEGLDLGIDIKGIEISKQIAHNARNNIEFFGYDRDIIICNDMHNLKEKYDIAIIDIPYGIFSPITYEEQVKIIKTSRKIAEKVILISFEDMDKELMQEGFKVIDKGTIVKNRFTRYITIAVNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMY9</accession>
    <name>A0A173YMY9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tqsA</name>
        <name evidence="7" type="ORF">ERS852471_00267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64697">
        <property type="protein sequence ID" value="CUN64697"/>
        <property type="gene ID" value="ERS852471_00267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="342" mass="38079" checksum="51E972DD0276D935" modified="2016-09-07" version="1">MIKRKYKSILIKICIVLIFILLLSIYFFYDPVRSVVNLILISFIIAYAIKPLRNYFCDKFKISKRISSLIIIILSIGLFTTIIYFIVPTIIYESGNFGVMLDNVELYLMNMANKLNLSDLSLFETAYIQINEKINLFLASLSGNLIDNIASILENLVGFAIVPVVAYYFLADGELIYNKLLLIFPTDKRILIRKINGNIDKVLSRYIISQLLLSGIIGVLTFIMLIILGIKLPLILAILNAIANIIPYFGPIIGGAPIVFIALMQSPTKAILALIGAFVIQQIEGDLLAPKITGVCINFHPIIIIILLILGGKIGGAAGMILAVPILVIIKVIYDDINYYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YTT7</accession>
    <name>A0A173YTT7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">def_1</name>
        <name evidence="2" type="synonym">def</name>
        <name evidence="3" type="ORF">ERS852471_00310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263239.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66939">
        <property type="protein sequence ID" value="CUN66939"/>
        <property type="gene ID" value="ERS852471_00310"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="147" mass="16518" checksum="B79367923F9496AE" modified="2016-09-07" version="1">MAIRNIRKIGDDVLRKKCKEITEITPRDLVLIKDMAETMYAADGVGLAAPQVGILKRLFVIDIRDEEGLMVFINPEILETSGSQIDDEGCLSVPGESCEVERPNYVKVRAFNEKGEQFILEAEGLLARAVLHENDHLNGVLYVDYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0Y3</accession>
    <name>A0A173Z0Y3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">khpA</name>
        <name evidence="3" type="ORF">ERS852471_00343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032118141.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68815">
        <property type="protein sequence ID" value="CUN68815"/>
        <property type="gene ID" value="ERS852471_00343"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN68815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="79" mass="8559" checksum="89D37E890F6AB522" modified="2016-09-07" version="1">MKELVEVIAKSLVDNPNEVHVNEVQGEQSLILQLKVAPEDMGKVIGKQGRVAKAIRTVVKAAALNEEKKVAVEIIDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z3G5</accession>
    <name>A0A173Z3G5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">frr</name>
        <name evidence="5" type="ORF">ERS852471_00357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263320.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69638">
        <property type="protein sequence ID" value="CUN69638"/>
        <property type="gene ID" value="ERS852471_00357"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN69638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="20628" checksum="92CC5C8F171842F4" modified="2016-09-07" version="1">MIKDIINTAEAKMKKTVSVLTSDLSTMKAGRANPTMLDRIFVDYYGSQCQLSQVANISAPEPRMLVITPWEKPLLKEIEKAILKSDLGINPSNDGSVIRLLVPELTEETRKRLVKNVKAVGEDAKIAIRSIRRDANEKIKALKKDGHISDDEVKKAEDGVQKKTDLFVKEIDGIIVAKEKEIMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z474</accession>
    <name>A0A173Z474_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263350.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70530">
        <property type="protein sequence ID" value="CUN70530"/>
        <property type="gene ID" value="ERS852471_00373"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017569">
        <property type="entry name" value="Enoyl_ACP_red-II_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03151">
        <property type="entry name" value="enACPred_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="308" mass="32841" checksum="602E8BC0E3C95E26" modified="2016-09-07" version="1">MKNDICKMLDIKYPIFQGGMAWVSDSSLASAVSNAGGLGIIAGATAPVDYIREEIRKTKKLTDKPFGLNIMLLSDNAEELAKIAVEEGVKVITTGAGNPGKYMSMWKEAGIKVIPVVPSVALAKRMERAGADAVIAEGCESGGHVGKLTTMVLVPQVVDAVNIPVIAAGGICDGRGITAAFALGARGIQMGTRFLVSDECTIHENYKNAVIKAKDIDTVVTGRVTGHPVQVIKNRLAREFLKLEASNVSAEKLEELGRGALRRAVKDGDVDNSSLMAGQISGMVSKKQSVKEIIEEIFNEYEELRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z4C1</accession>
    <name>A0A173Z4C1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 12">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fabF</name>
        <name evidence="16" type="ORF">ERS852471_00376</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263356.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70697">
        <property type="protein sequence ID" value="CUN70697"/>
        <property type="gene ID" value="ERS852471_00376"/>
    </dbReference>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="15">
        <location>
            <begin position="5"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="44510" checksum="5689532EF7BAB9D1" modified="2016-09-07" version="1">MKRRVVVTGMGAITPIGNSVSEFWNNVKKNKNGIEQITYFNTEDFKVKLAAEVKNFNVEDYIGKKDAKRMDKYTQFAVISSNEAIKDSKLELGNIDKERVGVVFGSGIGGIGTIENQINTLKDRGPSRVSPLTIPMGIANIAAGTIAIEHGILGSCLSLNSACATSTHAIGEAYRSIKDGYLDVIIAGGSEASITPFGIAGFQSLTALSRSEDKDRASIPFDKDRNGFVMGEGAGALILEDLDSALKRGAKIYAEVVGYGTTCDAYHITSPSSDGDGAARAMIQAMKDADISSRHIGYINAHGTSTEINDKVETLAVKKATGEDYKNIYVSSTKSMTGHLLGAAGAIEAIISIKSLEEDFIPATINYKNEDEECDLNLVVNEGIRKEYDYAMSNSLGFGGHNGTLIFKKWRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5F4</accession>
    <name>A0A173Z5F4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263387.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71642">
        <property type="protein sequence ID" value="CUN71642"/>
        <property type="gene ID" value="ERS852471_00394"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1823496at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="17579" checksum="13FD2F9AD5360974" modified="2016-09-07" version="1">MIKFRLARKGDEKEVLTLIDIVLSEYGLNLEPSGADFDVTDITKFYFNNKGWFQVIEDDNKIIGSVGVYKINDSTCELRKMYLYKEYQGKSLGKTLLKNALQSAQNLGYTTMTLQTNSLLTKALPLYESFGFKKNNDEVCSICDISMQKDIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7Z6</accession>
    <name>A0A173Z7Z6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263385.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71596">
        <property type="protein sequence ID" value="CUN71596"/>
        <property type="gene ID" value="ERS852471_00393"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1596922at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="35965" checksum="2A5B2F49F094733E" modified="2016-09-07" version="1">MKTKKLTEAAMLSALFVVVSIVAISTGLMYSIYLDIIVPIFISILYLKIGFKYTVLSSLTSLIIVALAIGDVPSAIWMSQGIILGLICGFFVSKKGAILDDILWSSIGGCFVVILVDVYLSTLTGYSLLKDFDSVAVMFPLNEEITKMAFYIFVATIPVGTALVSYVGALFIGHKLNILNKASKEKYNILKNFKKIGSYLCCSKRTYFISVTYLLIVEIINNTNFTINSTYIKTVIMSVRVVFMYFIIKDSIGFIRKYIYIRSKSATVAQVVSFAILYLLIVNIYITTILLIIGSVTVNFLLKIRDKEINIVNQYLELEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZED3</accession>
    <name>A0A173ZED3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase accessory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263475.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74143">
        <property type="protein sequence ID" value="CUN74143"/>
        <property type="gene ID" value="ERS852471_00444"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="91"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN74143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="38369" checksum="31C18B3F83EE31CC" modified="2016-09-07" version="1">MKKDFYTKLYNALNRSKDVYLITIVSGEYEGENIAGQKLFKIDDNIVIEDERYEEVWGDILKNIKLNKDTCSVTYDKKEVFIEYLASKPNLVICGGGHIALPLCNIGKLLDFRVTVIDDRKEFANSDRFNLADEVICGNFEEVLKENIFNKNTYFVIVTRGHKDDRRCLEFAIDKDYAYVGMIGSKAKVAIVVESLLEAGYSRELIDKVHTPIGLKIGGQTPAEIAVSIAAEIIKEKNINQKTEISEEILKEIIEDNQAKVLATIVEKVGSSPRGIGTKMLIKEDKSFKGTVGGGSVENAVYLKGLELIDSRSSDVEMYNLSNSDASTLGMVCGGKVKVIFEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFV1</accession>
    <name>A0A173ZFV1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263489.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74549">
        <property type="protein sequence ID" value="CUN74549"/>
        <property type="gene ID" value="ERS852471_00451"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="258" mass="30009" checksum="9EB6518C6C1C18A5" modified="2016-09-07" version="1">MIVMSFNLRSDFILDINNRWVNRKDIVKEIILKYNCDIIGVQELTNKMHKDIIEFAKDFNIVGRARSKKLFAERNDLIIPKKHSIEDHKTIWLSNTPNKIGSQPWFSLYPRICTTAKIKLDDNTKIRVYNTHLDCLLPQARDYGIKKLGKFIDSNYREDKLPVIVMGDFNATPNSKVIKNFASGKYYDKRFFAVQDKNKDLYNKPTRAGFKGKDTGSHIDYIFVSEELEIVDVDIITDNLNSKFPSDHFPLIADIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGF0</accession>
    <name>A0A173ZGF0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263511.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75197">
        <property type="protein sequence ID" value="CUN75197"/>
        <property type="gene ID" value="ERS852471_00464"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="123" mass="14378" checksum="0E21D94CF1C3FE92" modified="2016-09-07" version="1">MKECKFQKSLNIITREFKECKKVLLAIGDDTRQAIIIALLESDCNGIRVGEITKKTHLSRPAVSHHLKILKESGIINMRREGTKNYYYMDANKRQWEKVSSLVNHIYDVVKEFEPIDKRQVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZI17</accession>
    <name>A0A173ZI17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl xylan esterase</fullName>
            <ecNumber evidence="2">3.1.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cah_2</name>
        <name evidence="2" type="ORF">ERS852471_00474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263527.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75767">
        <property type="protein sequence ID" value="CUN75767"/>
        <property type="gene ID" value="ERS852471_00474"/>
    </dbReference>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047739">
        <property type="term" value="F:cephalosporin-C deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="318" mass="37204" checksum="0E295E3C13B04465" modified="2016-09-07" version="1">MPALDMNMKYMEKYLGQTIKPRDFDLFWKKQKDLADNLELDYRITNKNFNNNNGNYYEINFRGIDGANIYAKYIRPNTEEKVPTVLEFHDYKKASRSWHHLTRYIGVNYSVVAMDCRGQGGKSEDLGNIKGSTVCGNLINGLDDVKENMYYCKVYLDAYILSRIVEELESTDKSRMIAFGKGQGAAIALVVSSLNKNIKKCSMQYPFLCDFKRVYDMDLDVDAYEGLRYYFRWFDPMHLRGKEVFEKLGYIDIVNFANKLNCEILMGTALLDTICPPSTQYAVYNNLNCNKKHIIFPKYDHELNNFFENENLKFMRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJG0</accession>
    <name>A0A173ZJG0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">htpG</name>
        <name evidence="7" type="ORF">ERS852471_00477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263531.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75943">
        <property type="protein sequence ID" value="CUN75943"/>
        <property type="gene ID" value="ERS852471_00477"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="26"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="550"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="623" mass="72407" checksum="F0DD2EE36D7F3DFE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6S6</accession>
    <name>A0A174A6S6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84341">
        <property type="protein sequence ID" value="CUN84341"/>
        <property type="gene ID" value="ERS852471_00563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="55" mass="5722" checksum="46F2DDADEA07DE47" modified="2016-09-07" version="1">MNKKTINTIFKVVGLSMGVATLALSIITTIDINTSITLLSIGLTSLGIAQLSSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AEX4</accession>
    <name>A0A174AEX4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subtilase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263747.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86045">
        <property type="protein sequence ID" value="CUN86045"/>
        <property type="gene ID" value="ERS852471_00585"/>
    </dbReference>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="100"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="439"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN86045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="596" mass="66696" checksum="6E3EAE3B110DF234" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B397</accession>
    <name>A0A174B397_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fccA_2</name>
        <name evidence="6" type="ORF">ERS852471_00701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN95174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95174">
        <property type="protein sequence ID" value="CUN95174"/>
        <property type="gene ID" value="ERS852471_00701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018114" evidence="4">
        <location>
            <begin position="25"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN95174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="595" mass="62840" checksum="FEB16AFE95BA7B62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B7M2</accession>
    <name>A0A174B7M2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
            <ecNumber evidence="2">4.4.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gloA</name>
        <name evidence="2" type="ORF">ERS852471_00716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263998.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96189">
        <property type="protein sequence ID" value="CUN96189"/>
        <property type="gene ID" value="ERS852471_00716"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="127" mass="14678" checksum="6F7EAF6459CD68F9" modified="2016-09-07" version="1">MAVKMLHTCIRVMDLEKSLKFYREALGLVETRRKDFPEHKFTLVYLSNEIGGYEIELTYNYNPEKPYELGNGFSHIAVGVDDLEGEREKHKTLGYEVTPLKGLPGQKPGYYFVTDPDGYKVEVIRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B8Q8</accession>
    <name>A0A174B8Q8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96803">
        <property type="protein sequence ID" value="CUN96803"/>
        <property type="gene ID" value="ERS852471_00728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="342" mass="38467" checksum="7A79F4A11D0FE283" modified="2016-09-07" version="1">MDKSEVKKNIIAKTILFVCIMVFIAIFTLIFGQENVPVGICTVIILLMLLGKNLTQKPLKNFLILLGINLAIGFGTYIAANNVWIGIFIDFFTLSLIGYYFSYAMTKGLILPYGLQYLFLLNSPVHGEVFVKRILALVAGAVIIMISQFIVNAKKENAFKKENSIIGFNENESNKVYKEVNIFGRKVKIHTIRASYAIRVGILVALTSFIQQYFKLAEGRWMVYTIFSLTELYSENCKIKAWKRLQGTIIGSIILLILFMFIKNNILRGLIILIAGYLNSFAEDYRDMVVLVTISAVAPLAISNGSIYAVVERIMYVIIGIILSLIANALILRKSKKDIETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIX0</accession>
    <name>A0A174BIX0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264121.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99670">
        <property type="protein sequence ID" value="CUN99670"/>
        <property type="gene ID" value="ERS852471_00782"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="26185" checksum="BEAED85355C036CA" modified="2016-09-07" version="1">MYKRGDFHIHSTASDGALKPEEIVLFAKKRNLDIISLTDHNTVAGVEAAVKCGKTHGIKVIPALELSTRYKGIRIHILGYFNCDIYQNELFIDTINNIKKGNISYIKNRFKDILTLNRGSKKISIEDGIKILKYFNAVVVLAHPVLLPRNIFSEVVVMDFDGLEAKYFANTEEDTEYFIEIANKRNMIYTAGSDYHNGYDYYRAHGCIGDVFLEEEEIKRFLERLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJC6</accession>
    <name>A0A174BJC6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Na(+)/H(+) antiporterprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_00808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264178.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01102">
        <property type="protein sequence ID" value="CUO01102"/>
        <property type="gene ID" value="ERS852471_00808"/>
    </dbReference>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO01102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="399" mass="42279" checksum="4F6800711AA36BB9" modified="2016-09-07" version="1">MSWFYYLAIILIFGLLMGKVVSYLKLPRVTGYLIAGVLIGPFVLKLVPHEAIESLTIISEAALGFIAYNIGSSLNYNKLKNIGKGVIIIALFEALMATFVVTLAMKFIFGQTWEFSLAIGAIASATAPAATIMVLKQYKAKGPLVDTLIPVVAIDDAIAVIAFGISIAIAQIISKGSDGVSIMAFLNPFIEIFFSIVLGCAVGFALTYFNKLSKQKENAMNLVIAAIFLVIGLADLLDLSNLLACMALGATVSNLVLSKSKLLSSIDNITSPIFIMFFTISGLELDLSVLLTVGLIGIGYVVFRVIGKVLGAYIGAQLANSQPVVKKYLGLTLVPQAGVAIGLTMIVQEALPSCGASIRAIILAGTVIYELIGPLCTKIAIFKAGEATVDAHHKIEISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BK14</accession>
    <name>A0A174BK14_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoP2</name>
        <name evidence="11" type="ORF">ERS852471_00805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264172.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00913">
        <property type="protein sequence ID" value="CUO00913"/>
        <property type="gene ID" value="ERS852471_00805"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO00913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="234" mass="26892" checksum="78273C575B5B570F" modified="2016-09-07" version="1">MDLYSVLVVEDENDIAVAIEAYLTNQGYKVFIANNGIEGLEVLEKETIHLAIVDVMMPRMDGITFVMKLREKHDFPVIMLSAKSEEVDKIMGLNIGADDYVTKPFRPLELLARVNSQLRRYSKFLNMVSNKEINENIYSVGGLELNIETKEVTVDEKAVKLTPIEFKILALLMKNPGRVFSAEEIYERVWNEQAINTDTIMVHVRKIREKIEVNPKNPKYLKVVWGVGYKIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQR1</accession>
    <name>A0A174BQR1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264258.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03431">
        <property type="protein sequence ID" value="CUO03431"/>
        <property type="gene ID" value="ERS852471_00854"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139537at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO03431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="392" mass="46483" checksum="FBFA268157DC43FC" modified="2016-09-07" version="1">MKELIETLRRNSIIKSLMDEFKKDFKNTYYDATLKQKEMLIDYRDVIFRRWLYSPLRGGTYLTPSYIINNIAQQIYPGDYCIMPYIKVDLDNEGRLKFYRKFNYHSFNNSPVINDLEKLIDFLKPTIIVRDENKYVIDGGERLINRLSIQSDYYIEYLINIATNIGILEPMKSIGCRCYKIGKDYYNYINLKIDEKIKIIINSSIDIVRESISDIIEFDNTNSIFDLLDNGVTEEKFFQMMKPSLKENMEHSKCISDSLKVDEKTIYNITEEVLSDEIGYWLVRREAGIYLDTYLTCILGYYLGIINPIYDELFLTKIFIDFISYTDNPIERLSIIFTMELGHNLTRFGEKIIMERKIIKGNNFKDLVPKNIKSCIEEYKNKKDNILYHIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C281</accession>
    <name>A0A174C281_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exoaminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ysdC_2</name>
        <name evidence="9" type="ORF">ERS852471_00906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264374.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07601">
        <property type="protein sequence ID" value="CUO07601"/>
        <property type="gene ID" value="ERS852471_00906"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO07601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="368" mass="40509" checksum="E152FF0BC20929EE" modified="2016-09-07" version="1">MSLSKESSIYDVDLDMLRELSEADGISGCEKEVSRVMKKYLEKYSDEISYDNLGSIIGLKKGKEDGPKIMIAGHLDEVGFIVRDIDKDGYVKLLPVGGWWGHVLPSQRLIITTSEGKKIVGVVGSRAPHGMPAKEKEKVILPKDLHLDLGVDNREEVEALGIQIGDMITPDTKFEVMNNPNYLLGKAWDDRIGAAVAIDVLRELDGVEHDANVYSVGTVQEEVGIRGARTATANIKPDIAFALDVTTAKDTPMDKGGAKLGGGIILSVLDSLSLANRGLLNKLEAIASEVGLELNYDFMVAGGTDTANIHKSFDGIIAMTLSIPTRYMHSHRLVIHRRDYVETVKIIAEFCKRVDRELLEEIRLNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4S3</accession>
    <name>A0A174C4S3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264350.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06885">
        <property type="protein sequence ID" value="CUO06885"/>
        <property type="gene ID" value="ERS852471_00894"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2064901at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="120" mass="14123" checksum="108F3C33301FBFB3" modified="2016-09-07" version="1">MSLEVVGCYRELSSIKEECKTYLSYHAVLIMSDGSTCDGIIEGVDDDSDEIIVLVGEDVVIDDGDNMSRQQPMGYKGPNRYRRFRRRKFPINRINRLDLLRYPFIYPVYPYPYPYPFFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C521</accession>
    <name>A0A174C521_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ypdA_2</name>
        <name evidence="6" type="ORF">ERS852471_00925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264413.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08621">
        <property type="protein sequence ID" value="CUO08621"/>
        <property type="gene ID" value="ERS852471_00925"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="586" mass="67925" checksum="A5E4A881D321061E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6X5</accession>
    <name>A0A174C6X5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fumB</name>
        <name evidence="4" type="ORF">ERS852471_00904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264370.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07498">
        <property type="protein sequence ID" value="CUO07498"/>
        <property type="gene ID" value="ERS852471_00904"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="185" mass="20467" checksum="C53B0C6769CD7AD5" modified="2016-09-07" version="1">MEIRLETPLTYDKIKDLKAGDSVLLSGVIYSARDAAHKRLIELLEAGKELPIEIKDQTIYYVGPSPEKPGQVIGSAGPTTSYRMDDYTPQLLNLGLKGMIGKGKRNDEVVKSIVENKAVYFGAIGGAAALMAQRVEECEIVAYEDLGAEAIRKIRIKDLPLIVIIDSEGNNLYKIGREEYLKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBQ4</accession>
    <name>A0A174CBQ4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 8 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">pgk</name>
        <name evidence="13" type="ORF">ERS852471_00937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 8 11"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264437.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09265">
        <property type="protein sequence ID" value="CUO09265"/>
        <property type="gene ID" value="ERS852471_00937"/>
    </dbReference>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO09265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="392" mass="41954" checksum="09CA287DFA09F4EA" modified="2016-09-07" version="1">MNFNKKTIEDVQVNGKRVLVRCDFNVPLKDGVITDENRLVGALPTIKYLVENGAKVILCSHLGKDASKTLAPVAVRLSEMLGKEVVFARDEEVVGENARKAVADMKDGDVVLLENTRCRKEETKNGEELSKELASLCDIYVNDAFGTAHRAHSSTEGVTKFVDTAVCGYLIQKELKFLGEAVNAPVRPFVAILGGSKVSDKIAVINNLLEKVDTIIIGGGMAYTFLKAQGYEIGTSLCEDDRMDYAKEMIAKAEANGVKFLLPVDHRIADGFKDVEATVTEDQNIPAGFMGLDIGPKTEALYADAIKDAKTVIWNGPMGVFEFENFNKGTIAVAKAMADADATTVIGGGDSAAAVNILGFGDKMTHISTGGGASLEFLEGKVLPGIAALNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGG8</accession>
    <name>A0A174CGG8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent RNase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264509.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11279">
        <property type="protein sequence ID" value="CUO11279"/>
        <property type="gene ID" value="ERS852471_00978"/>
    </dbReference>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="231"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO11279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="418" mass="46553" checksum="E267EA0432E45649" modified="2016-09-07" version="1">MIKLYSLGGSGENGRNCYAIEWSEGVILLDCGVKREINENGVGDYPVLTKELVSKLRFVLLSHAHEDHSASLPLIYSMGYRGKVYASSPTANSTPNFMNKWKNFVKENNGVIPFSEEDITKVEFETLNIGLNNIDGVEITVGRSGHVVGGIWFIVNVEGKKIFYSGDIVSEPMLLHNDKPHEVDAAILNCAYAGKILKQSQQYEILLNSVKETLSIGGKAVLPLPPNGRGCDIYKFLCENIKDMPLYVDKEIIDNYKKLSDMTDWVKNIEGSLDSGNVVCIDTMEDREEVCLKDEPSVILTQDGMLTAVQGKYYFEHLKEDSRNKVIITGHAAKGTIGAEIFNDEYCKNNLVKLQKGHVIFKVHFDDVDVVEFNEYLKAKTIILFHSNKDKTVNVISNLANTGVSAMCLSTGESYNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHU5</accession>
    <name>A0A174CHU5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">apgM</name>
        <name evidence="6" type="ORF">ERS852471_00979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264511.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11325">
        <property type="protein sequence ID" value="CUO11325"/>
        <property type="gene ID" value="ERS852471_00979"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293048at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="8"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="414" mass="45598" checksum="AC97EE0CA0C3B218" modified="2016-09-07" version="1">MGKAKGIYLIADGLGDRPIAELNGLTPLEYANTPTMDLLCKEGMTGLVHPYRPGCRVGTDWGHICLFGYNPDEHYTGRGAVEAYSAGLEMKKGDVAFRGNLGTVDDDLVVIDRRAGRIKDKEDIKALIEAVDGYEVDGCTFKILSLTEHRVAVVMSGEDLDWHIVDTDPGTACEGSKMICPIQENNYQKSAEALWKFQLHVKEVWDKHPVNIEREKKGLHKANFIITRGAAAAMVLPPIESIFPKVKVSVIAGDETITGIGKMCNFDYATDESFTGGFDTNYLGKAQKVLDELENHDLVIVHIKGTDLCGHDNEPLKKAKIVEQIDAMFTYWLTKIDKDNTYLALAADHSTPCHVRDHSADPVPAFLWGPNVRVDECTSCGERAIAKGIINGYTGAQFMSTIMDYLGHTKKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJI4</accession>
    <name>A0A174CJI4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate responsive antiterminator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygcP</name>
        <name evidence="1" type="ORF">ERS852471_00991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264526.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11875">
        <property type="protein sequence ID" value="CUO11875"/>
        <property type="gene ID" value="ERS852471_00991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006699">
        <property type="entry name" value="GlpP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35787">
        <property type="entry name" value="PTHR35787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04309">
        <property type="entry name" value="G3P_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016897">
        <property type="entry name" value="GlpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="186" mass="20395" checksum="F9099B208C417722" modified="2016-09-07" version="1">MIEMKKVLEGNPVIAAVKDMKSLEEAIETDIDIIFVLFGDIISIKEISEKIKGKDKIGIIHIDLVEGLSNKEISIKFIKNETSFDGIISTKGNLIKQAKNYGLVAIQRFFVFDTISLNNSKNHVISECDAIEILPGVIPKVVKDISTFTRKPVVSGGLIDTKEDVILALNSGATCVSTSKTEIWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CN06</accession>
    <name>A0A174CN06_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">ERS852471_01013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264544.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13115">
        <property type="protein sequence ID" value="CUO13115"/>
        <property type="gene ID" value="ERS852471_01013"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="431" mass="47831" checksum="C94D694D034A5642" modified="2016-09-07" version="1">MADLKVYPSKLEGSIKVPPSKSMAHRAIICASLSDGKSKIDNIDYSDDIIATIEGMKALGANIIKKGDSLEVEGIYSSSLNRNEERIIDCNESGSTLRFLVPISLLIPGKSKFVGRGNLGKRPLKTYYEIFDKQGIKYSYENEKLNLDIEGNLKGGKFYVEGNVSSQFITGLLFTLPLLKEDSKIVITTEMESKGYIDLTLSAMKEFGIDIINNDYREFIIKGNQKYTSRDYRVEGDYSQGAFFLCANALGNDIEVKDLSLKSLQGDKEVVDILERMGVEFINSENGIRSKVKNEINSTIIDGSQCPDIIPVLAATAALAKGRTEIINARRLRIKECDRLAAVNSELSKLGVNVVENEDGLIIDGIDSLDGGIEVWSHKDHRIAMTLAIIATRCKNPIIIKDYECIAKSYPNFFEDYKMLGGKVDEWNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5F9</accession>
    <name>A0A174D5F9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264629.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19305">
        <property type="protein sequence ID" value="CUO19305"/>
        <property type="gene ID" value="ERS852471_01109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="31304" checksum="21AEA5367EBD639D" modified="2016-09-07" version="1">MGSDKNRIQESKGYGRECDEEYYMKECYHQDYDCKCDDKEYDRDCYDYDKKYDHKEYDKKCDDHDYDKKCEHDYDDRKCEHHDYDKKHDVKVIQTKVIKGTGCKDFFLEADFDFPQGTPLYLIESIDTWVDVYDTKVICEDKVIFNAWVYKNIIYKVVSGSPVQDDGVTVTGGVDHITKAIPLAGCINIDTKKCGKLDPCRDFAEVIKAKVIGHVEDKLEKVEIKQGNGESFNPPVFVYGSLHEKMCVRIDLKVVRWEHVSVEIEDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DB18</accession>
    <name>A0A174DB18_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnA_2</name>
        <name evidence="3" type="ORF">ERS852471_01153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21489">
        <property type="protein sequence ID" value="CUO21489"/>
        <property type="gene ID" value="ERS852471_01153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="182"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="665" mass="75667" checksum="2FB902752AE3373F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DC78</accession>
    <name>A0A174DC78_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Desulfoferrodoxin</fullName>
            <ecNumber evidence="5">1.15.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Superoxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dfx</name>
        <name evidence="15" type="ORF">ERS852471_01194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]</text>
            <dbReference type="Rhea" id="RHEA:21324"/>
            <dbReference type="Rhea" id="RHEA-COMP:10302"/>
            <dbReference type="Rhea" id="RHEA-COMP:10303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.15.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264705.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23312">
        <property type="protein sequence ID" value="CUO23312"/>
        <property type="gene ID" value="ERS852471_01194"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1496450at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050605">
        <property type="term" value="F:superoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00974">
        <property type="entry name" value="DSRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004462">
        <property type="entry name" value="Desulfoferrodoxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038094">
        <property type="entry name" value="Desulfoferrodoxin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004793">
        <property type="entry name" value="Desulfoferrodoxin_rbo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06397">
        <property type="entry name" value="Desulfoferrod_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00319">
        <property type="entry name" value="desulf_FeS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00320">
        <property type="entry name" value="dfx_rbo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrod_N" evidence="14">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Desulfoferrodox" evidence="13">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO23312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="128" mass="14533" checksum="70431615524E4539" modified="2016-09-07" version="1">MTKTNAIYKCNICGNIVEVLQEAPGMLVCCGKPMLLKDERTKEGVGEKHIPVVEKKDAGVFVKVGEVEHPMLQEHHIQWIEVLTDTEVYRLNLKPGDKPEGLFNVDYDNIVSVREYCNLHGLWSINLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DH81</accession>
    <name>A0A174DH81_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugtP</name>
        <name evidence="7" type="ORF">ERS852471_01193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264721.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23270">
        <property type="protein sequence ID" value="CUO23270"/>
        <property type="gene ID" value="ERS852471_01193"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="217"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO23270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="42666" checksum="1584E13CCFA104C9" modified="2016-09-07" version="1">MNILILSASTGGGHMRASRAIENYMSEHDKSANVKIVDSLLYINPILNKTVTSGYVYLATKTPKIYGKIYELTNKEDRWISFVNRLNYLFANKLLPLIDEFKPDVIITTHPFPTEMVSILKAKELVNIPLVCIMTDYAPHKTWVNQKVDAYIVSNDDMVKEMSKIGVREEVIYPYGIPIEQVFFEKKDKDLVLNELELNPNLPTILMMAGSFGVTNVFKIYEDIINIDREFQVIVITGKNQKLYDEFAKVINKSEKHTKLIYFTDEVNKFMQAADIIITKPGGLTITEALASNIPMAIFDAIPGQEEENAEFLINHNMAIKLEKNQSCDKLIEELLMNKEKLNNMKEACRSFDKNDSSKNICALINELVENSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQF4</accession>
    <name>A0A174DQF4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flr_2</name>
        <name evidence="3" type="ORF">ERS852471_01257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264799.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27684">
        <property type="protein sequence ID" value="CUO27684"/>
        <property type="gene ID" value="ERS852471_01257"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO27684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="29074" checksum="4B0FE36B584296C1" modified="2016-09-07" version="1">MTKKVDFKGSVILNPVPVVLITSRNKEGKENVFTVAWTGTVCTKPPMLSISVRPERLSYEYIKETMEFTVNLPTSKMTKAVDYCGVRPGRKFDKIKEMNFTMKEGTNINVPYIDECPISIECKVKSIIPLGTHDLFIADVVGSHVDASLMDDKGKIHFEEADLITYCHGEYYKMDKYPLGKFGYSVAKKPVEIKNSTLLKEKTTEKDSTKQNNFSKSKNKAKNKSSKSVVSSKKRNTSKNNSKFKKKTTNSNKQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQT0</accession>
    <name>A0A174DQT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LrgB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yohK</name>
        <name evidence="6" type="ORF">ERS852471_01263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264809.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27931">
        <property type="protein sequence ID" value="CUO27931"/>
        <property type="gene ID" value="ERS852471_01263"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1416872at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO27931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="234" mass="24998" checksum="A4FFA502A3303E79" modified="2016-09-07" version="1">MDIFTNNMFFGLFISLIAFEIGLIIYRKTKFPLFNPLLIAIIIVIGFLKVFNIDFDTYNQSGQFINMFLGPATIVLAVPLYKQFELLKKNFIPIIIGITIGSLVGILSVISISVFFKLDSLITISLLSKSVTTPIGIEITNQLGGLTPVTVLAIIISGIIGAVVAPTVCKVFKITNSVAVGVSIGTASHAVGTSKAFEIGETEGAMSSLSIGIAGVITVFLAPLCYNLLANFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXM4</accession>
    <name>A0A174DXM4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28785">
        <property type="protein sequence ID" value="CUO28785"/>
        <property type="gene ID" value="ERS852471_01281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="91"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO28785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="348" mass="39394" checksum="CB9FD9150E2A9C8C" modified="2016-09-07" version="1">MNSRSKDRKKVKKRKKYIIAVSLIFLIMTLVFWNLSIKKVTVLVDGKEIVHKTNKETVGDVIDELGITYSENDKLSKGISESISNNDNIVITRVSFKEETVEEDIAFEEKEVKDYKMPLGESRVIDEGQVGKKTLVYKITYENGVEVKRELINEEIISDASDRIIAKGIFDPTSMTVCVNKTRTVDSDYEPQDLVVPNVRSLVSTSRIMMKSEAAAALENLFKGADADGVYLYAVSGYRSYDYQASIYNPYSGYSAPPGASEHQLGLAMDVNSSYYGSSLTTEFGYSVEGQWVRENAHKYGFIVRYLPGKEDVTGYYYEPWHIRYVGVDLATELYNSGLTLEEYYGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EH53</accession>
    <name>A0A174EH53_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO36038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265091.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36038">
        <property type="protein sequence ID" value="CUO36038"/>
        <property type="gene ID" value="ERS852471_01422"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO36038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="17391" checksum="C0AAF19A4FA86E23" modified="2016-09-07" version="1">MANYDFSNIEDLKAEEKRLHEEYKQKLSELKKVQKEKEAVGQVFAKGLLPIYVLYILSMGPTNGNDISTKISERTKGLWSPSTGGIYPLLKKLEKEGLVVGEWNDLKKKTQKLYSLTPLGEKEFSYRKSLLKPKIEESLKVFRLVYGDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EN10</accession>
    <name>A0A174EN10_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1622)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265216.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39194">
        <property type="protein sequence ID" value="CUO39194"/>
        <property type="gene ID" value="ERS852471_01492"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="12804" checksum="27C8D91C84C14E13" modified="2016-09-07" version="1">MLHHLLESVIPVVISLLELIGVVIILVAGVKAFGEYVMNLIGKGHYNIKIDLGQALSLALEFKMGAEILKTVLVTKMEEIWILGAIIVLRAVLAFVIHWEVSAEKSHQEHKVEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPA1</accession>
    <name>A0A174EPA1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yrpC</name>
        <name evidence="7" type="synonym">murI</name>
        <name evidence="8" type="ORF">ERS852471_01475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265184.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38309">
        <property type="protein sequence ID" value="CUO38309"/>
        <property type="gene ID" value="ERS852471_01475"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="257" mass="28683" checksum="62A91CA76137DD09" modified="2016-09-07" version="1">MNKKEMPIGFLDSGLGGISVLREALKIMPNENYIYFGDSKNAPYGTKTKKEIRDLTFNTVEFLLEKGAKGIVVACNTATSAAVAELRLVYPNIPLVGIEPAIKPAVELGKKGKILMMATPMTVKQDKFKYLLNRYKDKADIIPIPCEGLMEFVENGKFTGEELEEYLKEKLHGYDSSNTSSIVLGCTHYPFVSEAIKNVIGNDIEIIDGGLGTAREIKRRLAEKDLLNDSHQKGKIEVYNSSDEERFIDLSWKLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F146</accession>
    <name>A0A174F146_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lic-1 operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">licC</name>
        <name evidence="2" type="ORF">ERS852471_01553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265336.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43277">
        <property type="protein sequence ID" value="CUO43277"/>
        <property type="gene ID" value="ERS852471_01553"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017189">
        <property type="entry name" value="CTP-phospocholine_CTT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037382">
        <property type="entry name" value="CCT_LicC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="230" mass="26716" checksum="C4EA7504F31C5DCA" modified="2016-09-07" version="1">MRAILLAAGMGTRLRPLTLETPKPLIKVNGESMIERQIEALKDIGVDEIIIVTGYLKEKFDFLKEKYGVKLIHNDKYNVYNNIYTMYLVKDYLRDVYVIEGDIYLNRNFLKANMEQSSYFSAPKYGYKDEWILRMDANDSVIDIEVGSEDGQHIMCGVSYWNDKDGKLIVEKLDECVKNGEFTELFWDDIVKNNISNLNIKVEKIDPNDVYEIDSLQDLDNLNEILSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4U4</accession>
    <name>A0A174F4U4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45263">
        <property type="protein sequence ID" value="CUO45263"/>
        <property type="gene ID" value="ERS852471_01593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="50" mass="6192" checksum="C36F5F29A056789C" modified="2016-09-07" version="1">MKNKIFLKIKDTYNKFNNEYKKTTVFGESRNSNVYLDMLEERIKFYIMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F598</accession>
    <name>A0A174F598_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPXTG-motif cell wall anchor domain-containing protein</fullName>
            <ecNumber evidence="3">3.2.1.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.89" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265430.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45522">
        <property type="protein sequence ID" value="CUO45522"/>
        <property type="gene ID" value="ERS852471_01601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1841063at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021355" evidence="2">
        <location>
            <begin position="34"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO45522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="530" mass="59162" checksum="BAE1C6153BD17B48" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FC87</accession>
    <name>A0A174FC87_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">regX3_2</name>
        <name evidence="6" type="ORF">ERS852471_01605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265438.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45755">
        <property type="protein sequence ID" value="CUO45755"/>
        <property type="gene ID" value="ERS852471_01605"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO45755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="112" mass="13384" checksum="5DD8625477BDDAA2" modified="2016-09-07" version="1">MVVERVDESIIEDEVWKYKNIKIDFSTYTFWVDDIGDELTHLNIELLKLFLSSKGKVLTREIIKERIWGEERLINDRNVDFQVWLLRKKLGLTKSELISIRSVGYKLNLRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCP5</accession>
    <name>A0A174FCP5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD_1</name>
        <name evidence="5" type="ORF">ERS852471_01634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265492.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48062">
        <property type="protein sequence ID" value="CUO48062"/>
        <property type="gene ID" value="ERS852471_01634"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="87"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO48062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="298" mass="34663" checksum="CD0C1BAA9E220F1E" modified="2016-09-07" version="1">MSTLERVVHKEFEGMKIREFLKFHMGLSSRLIRGASIDKRIFVNDVPVKMNYVLKDNDKILINLAKKESQNIEPEKIDLDIVYEDKDIIVINKRPNMVVHPTKRYQSGTLANGLLYYFKETGQDCIVRLVSRLDMDTSGLIIVAKNQYAHMELSKEMQENNVEKRYLAVVHGHLEKEEGTIDLPIYRPEEEGAIRRVIDERGQRSITHYKVVERLKDADVVECLLETGRTHQIRVHLKALGHPIYGDTLYGYEDDDKYMKRQALHAYGLDFKSPRTKEELSLRANLPDDIDNLLKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHK9</accession>
    <name>A0A174FHK9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MutS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mutS_3</name>
        <name evidence="5" type="ORF">ERS852471_01664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265550.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49643">
        <property type="protein sequence ID" value="CUO49643"/>
        <property type="gene ID" value="ERS852471_01664"/>
    </dbReference>
    <dbReference type="OrthoDB" id="596088at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="421"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO49643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="598" mass="69265" checksum="90D6458A51494F6B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNW7</accession>
    <name>A0A174FNW7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">metK</name>
        <name evidence="17" type="ORF">ERS852471_01697</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265607.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51207">
        <property type="protein sequence ID" value="CUO51207"/>
        <property type="gene ID" value="ERS852471_01697"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
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    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="123"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="241"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="247"/>
        </location>
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    <feature type="binding site" evidence="11">
        <location>
            <begin position="253"/>
            <end position="254"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <position position="278"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO51207.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="391" mass="42836" checksum="0B1B1F2C66517F7B" modified="2016-09-07" version="1">MKRLFTSESVTEGHPDKICDQISDGILDSILAKDPMARVACETAVTTGMVMVMGEISTSCYVDIPKVVRETIKEIGYDRAKYGFDCDTCAVLTSIDEQSSDIAMGVDEALESKTGNKDDVEAVGAGDQGMMFGFATNETPEFMPLPIAMAHRLSRRLSEVRKNGTLPYLRPDGKTQVTVEYDDNKVVRIDTIVISTQHGPEVSQEQIREDLMEHVIKAVVPAELLDDNTKYYINPTGRFVVGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGIADKLEIQLAYAIGVAKPVSIEIETFGTGKISEEEIVKVVENTFDLRPGAIIRDLGLRSPIYKQTAAYGHFGRNDLDLPWERLNKVEEIKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FU03</accession>
    <name>A0A174FU03_9CLOT</name>
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        <submittedName>
            <fullName evidence="2">Heptaprenyl diphosphate synthase component I</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ERS852471_01749</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53673">
        <property type="protein sequence ID" value="CUO53673"/>
        <property type="gene ID" value="ERS852471_01749"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Hpre_diP_synt_I"/>
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        <property type="entry name" value="Hpre_diP_synth_I"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="170" mass="18408" checksum="2EC0C44BE01D1382" modified="2016-09-07" version="1">MRKTSKMVYIGLLVAQALVLHIFERMIPVPFVTPGAKLGLSNLITVVALYTLENKRDAFLVVFLKLTLSTMFGGNLSSFMYSAAGGVLSFFAMVLVKESFKEKVSIVGVSATGAIFHNVGQLLVASSIVHNISVMLYLPVLSIVGIGTGIFIGVTANYLVRHLSRLPVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV11</accession>
    <name>A0A174FV11_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rimN</name>
        <name evidence="10" type="ORF">ERS852471_01723</name>
    </gene>
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        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52439">
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        <property type="gene ID" value="ERS852471_01723"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO52439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="349" mass="38246" checksum="AA811C661811A31B" modified="2016-09-07" version="1">MKTKVAIIKDIRDDIDYIKEAGSIIKDGGIVAFPTETVYGLGADALNSEAVKKIFIAKGRPQDNPLIVHVSSKDLSNLVKDVPKVAQDLMNKFWPGPLTIILDKKEIIPDETSAGLNTIGIRMPNNEIALKLIELSGKPIAAPSANISGRPSPTEVERCVEDLDGKVDYILGGNKSDIGVESTIVDCTVNPPMVLRPGGITLEMLREVDSRIEIDKALMSKPSDNLKPKAPGMKYRHYAPKASLKIIRGKNEKTIEIISEMLENYIDKNNKVAILTTDENVSRFNKGEIISLGSEKDLYQIAQNLFEALRKCDDLGVQYILCQGFEEAGVGLAIMNRLNKAAGYDIIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G3Z2</accession>
    <name>A0A174G3Z2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xerD_1</name>
        <name evidence="8" type="ORF">ERS852471_01800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265798.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57204">
        <property type="protein sequence ID" value="CUO57204"/>
        <property type="gene ID" value="ERS852471_01800"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO57204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="33823" checksum="9A3C632EDD223D35" modified="2016-09-07" version="1">MKEIVNEYRESLLQSHKSENTVYAYVTDVNLYIKYLNSKDIYLNESDNNTVSDYIQYLLDEGKSERSINRIVISLRSFYNFLKDHKIIRDIPKIYYKATDSTKKLPEILTVEEVDKIIKVVDKDCNKGIRDNALLELMYATGMKVSEIIGLKVECVNLDLSYVVCHDNRNYERVIPIGRSAKNAIKEYLKIRDLIAASGVDNLFVNLNGQQLTRQGVWRIVKEYSHKAGIKKDVNLNTFRHSFAVHLLQNGANVRAVQKLLGNQVLTYMDTYYEIINNDKINLVYKNSHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6N9</accession>
    <name>A0A174G6N9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF2953)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265770.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56509">
        <property type="protein sequence ID" value="CUO56509"/>
        <property type="gene ID" value="ERS852471_01786"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088134at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021338">
        <property type="entry name" value="DUF2953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11167">
        <property type="entry name" value="DUF2953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO56509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="187" mass="22074" checksum="3C9A68A3669F97E5" modified="2016-09-07" version="1">MIFFILLLFFIFIILLPIPIKVSAHYSNDNYYLKLYGINLYSNNDGIIRKLLNRKSNSSKKNNKNQKVNNAKTKNKESNKKSFSMKKVYYRLKINKFKPSIKFSLLGNYSFSDAALTAMSYGFFSNLNFIFLKVFSDFFKVKKFNYSLNPNFKNKFNINLTLNCIITFNFAQIIYILFLIRKKEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFN1</accession>
    <name>A0A174GFN1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferases group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265918.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59958">
        <property type="protein sequence ID" value="CUO59958"/>
        <property type="gene ID" value="ERS852471_01863"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="114"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="424" mass="49062" checksum="80BE5EB110CC9AC8" modified="2016-09-07" version="1">MKILFIACYSPLINNSASIETLQYLNNLAKDNEIDLLTVNFPENSIYYDEYILNMLDKKVNLHIISGGKIFEKIMPKKTLNKDEDNNGSNKSSFLKKNLKKAKAIVAVPDMYLNWARRASKYGIELVKKNNYDVIFSMHEPPSSHICALKIKEKFKDIPWVTYWSDPWLKDSTREGIGSIRKSIEGRWEKRVVELSDRFIFVTKANRDDYVKTYNIPIEKTYILTRGYDSNSYRDIKALGIPEKIDNFKVNFVYAGEIFSKLRDVNPFIDAVNQIKEKDIELFNSLNILFFGNIDDKSVESKLKSVENVNVSPRIPYKEALSYMLNSEVLLLFGNKNSKQIPAKIYDYFGAEGRIFVILGDENDPIKDVVLNNDKCIVVNNNEDEIIEGINKIIELVKENKLTKPLKEYEWANISERLNKILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GST1</accession>
    <name>A0A174GST1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266126.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65523">
        <property type="protein sequence ID" value="CUO65523"/>
        <property type="gene ID" value="ERS852471_01981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="85" mass="9537" checksum="9F1F450593936C96" modified="2016-09-07" version="1">MKKNWNNPELKNLSLRCTSSEGCPYENEVNATPSTLLPEIIWGDGKLGCTHWNNDLKGCEHPNYGIKRICWPCPPVKVCPPTNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSV4</accession>
    <name>A0A174GSV4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livH_1</name>
        <name evidence="7" type="ORF">ERS852471_01948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266068.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64238">
        <property type="protein sequence ID" value="CUO64238"/>
        <property type="gene ID" value="ERS852471_01948"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO64238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="30370" checksum="6A38766EAF1A4504" modified="2016-09-07" version="1">MAFIQQIINGLSLGSIYALIALGYTMVYGIIKLINFAHGDIYMIGAFVGLYCGTTLKLSLIPTLLISMLGAALVGVIVEKVAYKPLRNSPRITLLITAIGVSLLLQNGMRLLMGPSPKAFPKLLSKEVIKIGALSIETSKILMLAVSIVLVLLLQIIVYKTKVGKAMRGASYDIEAASLMGINVNNIISLTFAIGSALAGAAGVLVSLAFTVVEPYMGTIPGLKAFIAAVLGGIGSIPGALVGGLLIGVTETLTKAYISTTLSDAIVFAILIIILLVKPTGLLGKKVNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXM7</accession>
    <name>A0A174GXM7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lacZ_1</name>
        <name evidence="8" type="ORF">ERS852471_02012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266195.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67374">
        <property type="protein sequence ID" value="CUO67374"/>
        <property type="gene ID" value="ERS852471_02012"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2160461at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4981" evidence="7">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Bgal_small_N" evidence="6">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="340" mass="39582" checksum="FF43C1790B6CEA62" modified="2016-09-07" version="1">MYTKVHNIKEFLKENRDKPMICCEYAHAMGNSLGALYKYTDLTEEDPLYQGGFIWDFIDQAIVKENSNGKKFLAYGGDFEDRPTDYNFCGNGLVFANREVTPKMAEVKYCYQNIKIIILEDKINIKNKNLFTNLNEYECFFILTRDGVEIDRKTTIIDLAPMSEKSIEIPFVRENNIGEYILTVSFCLSKDEIWAEQGYEIAFEQKVLYVVKKDKKEYKGNLSIVDGDIHVGVHGENFRVLFSRVKGGLVSYVYDGKEYILERPKLNFWRAPVDNDIANGMTFNNSIWKIASLYGKATMKSFKELEEGIEVWYTHTLPMLDMVLCQYFGHKKSNFFMLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXX9</accession>
    <name>A0A174GXX9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional antiterminator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">licR</name>
        <name evidence="5" type="ORF">ERS852471_02018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266208.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67602">
        <property type="protein sequence ID" value="CUO67602"/>
        <property type="gene ID" value="ERS852471_02018"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="284"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="3">
        <location>
            <begin position="491"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO67602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="637" mass="74850" checksum="E7404F66B2A9DABD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0H0</accession>
    <name>A0A174H0H0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein RecA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recA_2</name>
        <name evidence="7" type="ORF">ERS852471_02043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO68522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68522">
        <property type="protein sequence ID" value="CUO68522"/>
        <property type="gene ID" value="ERS852471_02043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="6">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO68522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="179" mass="19566" checksum="22B1D27DDDB4D7A4" modified="2016-09-07" version="1">MSQPDTGEEALEIAEALVRTNAIDVIIIDSIAALVPRAEIEGEMGASHIGLQARLMSQALRKLTGAISKSKCTVIFINQLREKIGIMFGNPETTAGGRALKFFASVRLDIRRIDTIKNGEQFLGNRVKVKVIKNKVSAPFKIAEFDIMFNEGISKEGNLVDIAVNDGIIQKSGAWFSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9E5</accession>
    <name>A0A174H9E5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GatB/YqeY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqeY</name>
        <name evidence="1" type="ORF">ERS852471_02083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266316.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70017">
        <property type="protein sequence ID" value="CUO70017"/>
        <property type="gene ID" value="ERS852471_02083"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="144" mass="16448" checksum="9484C4686593380C" modified="2016-09-07" version="1">MLKEQLKKDEIAAMKARDKARVSVLRMVSAEIKAYEVNNREDISDENVIKIIEKSIKQTKEALEYAKQANNEEKIQEGNFALEVLTPYLPKQLSEEEVTEMLKEIIANGNYTAKDMGKIMKEIMPMIAGKFDRSKINPMVKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBE5</accession>
    <name>A0A174HBE5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar metabolism transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glcR</name>
        <name evidence="5" type="ORF">ERS852471_02088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266326.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70205">
        <property type="protein sequence ID" value="CUO70205"/>
        <property type="gene ID" value="ERS852471_02088"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO70205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="28315" checksum="13893662912934A9" modified="2016-09-07" version="1">MVLIDRWIEILEYLKVKKFATVEEMMEKFEISRSTLRRDLIAMEDRGHIKRTRGGAEIIEKNDDNLEWVSLSEIFKYKKEEKIEIAKVAAKLIKDNDVIFIDSGSTCYYMIDYINAKNITVVTNGILHIQKLMAKGINTYILGGYAKPELNLIIGEDIVSKINVMNFDIAFLGTMGIDSKSGFTTQLLSDGEVKRAVISSAEKCFVLADTSKFNKRKFYTYGEFSEATVITNSEVEFEDSKIDIIYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HC24</accession>
    <name>A0A174HC24_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="4 14">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">luxS</name>
        <name evidence="15" type="ORF">ERS852471_02099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the LuxS family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="4 14"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266342.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70670">
        <property type="protein sequence ID" value="CUO70670"/>
        <property type="gene ID" value="ERS852471_02099"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1779617at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00091">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006160">
        <property type="entry name" value="AI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO70670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="151" mass="17151" checksum="BBDAEB80F42FE3A8" modified="2016-09-07" version="1">MEKVESFELDHRKVKAPYIRKCCVLNGEKGDKVSKFDVRFLQPNKEAFGTAAMHGLEHLLAHTLREKLEGVIDLSPMGCRTGFYLTIWGDRECNEIKEAVEYSLNKVLEATEIPAKNEVQCGNYRDLSLFGAQEYAKEALEKGFSLNIYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQ26</accession>
    <name>A0A174HQ26_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluB_2</name>
        <name evidence="5" type="ORF">ERS852471_02210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266536.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75228">
        <property type="protein sequence ID" value="CUO75228"/>
        <property type="gene ID" value="ERS852471_02210"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO75228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="238" mass="27295" checksum="46B5D87E8D8092E0" modified="2016-09-07" version="1">MERLDKILANLGYGTRKELKKIVRNGIVEVNGVVAKDSAMQVDPEKDKIVINGEEIYYREFIYLMMNKPDGVVSATYDNRDETVVDLLEVEHQVFEPFPVGRLDKDTVGLLLLTNDGELNHRLISPKWKVDKVYFARIDKEVTEADIKAFQKGITLDDGYVCKEAKLEIQSASEEGSEVLVTIQEGKFHQVKRMFEAVGKKVVYLKRIEFGTLKLDEELEEGEYRELTEEEIAILKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRH6</accession>
    <name>A0A174HRH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilE1</name>
        <name evidence="2" type="ORF">ERS852471_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266563.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75718">
        <property type="protein sequence ID" value="CUO75718"/>
        <property type="gene ID" value="ERS852471_02225"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2209039at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="164" mass="17590" checksum="9A5F47DAF383C354" modified="2016-09-07" version="1">MKLNKKKKGFTLIELMAVIAIVAILAAVLVPTVSGYINRSKKSAIVTQARTVVNAVESYNATSENPLIETLTDSGELPISTTLVSALPSIVGTDILDLNAISKLGNMTLAEAKAINFDSDAIKNLKIYPDGVFARYKELRVAAHTELVGEEGSEQAKYPVTNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ICM1</accession>
    <name>A0A174ICM1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nreC</name>
        <name evidence="8" type="ORF">ERS852471_02437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266926.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84211">
        <property type="protein sequence ID" value="CUO84211"/>
        <property type="gene ID" value="ERS852471_02437"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="6">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO84211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="23903" checksum="86F4B598A18B289A" modified="2016-09-07" version="1">MEKIKILIVDDDSLIRESLKIILSSDDKIEVLSTASNGQEAVDYCIKNSVDIALVDIRMPLVNGVKATKEITKRTNTKVIILTTFDEDEYIKEALNYGAKGYLLKNTSPRKIIETIKVVSSGNCVIQEEVLNKITDKLLKVNNKSEKKIDTSLFTERELNIMEAIADGLTNKEISKKLFISEGTVKNYITSILDKTDLEHRTQIAIYYIKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IE40</accession>
    <name>A0A174IE40_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266936.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84426">
        <property type="protein sequence ID" value="CUO84426"/>
        <property type="gene ID" value="ERS852471_02443"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="382" mass="43090" checksum="024EE0D5D6876754" modified="2016-09-07" version="1">MANVWILFKNNLYISVVKKKVNFILTLVAPILILLLMGKILSFGGGNSLNIGIVDNDNTKTTEALVEFLQDTNFINVINMDENDINNKLAERTIFGVISFKEGYEEALFTGNEDKILITTTENDVDIKDIISDMLYPEVVNIRNLANVCESKQEYIEVLDSYKNDGEVKIERKPLSDLREDYLKSSIFVGFIIFFMLLRGSSGSLHYYEEKDENVFNRLFMAPVESYQYYLADLLSNYLVVFIQAIIGILGMKILGTNIGVSSGMLLLIMGVVGLVSVSLAICIRAFCNTYSEFNMIFNFLNIILIIVGGCFVPLDIMPKLVNNISYLTPTRWAMEAISDLQLGLGFKDIVPHIFIIILFAVVFFVIGSYKTTKSEKEFSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IYI7</accession>
    <name>A0A174IYI7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uraA</name>
        <name evidence="8" type="ORF">ERS852471_02595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267197.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91471">
        <property type="protein sequence ID" value="CUO91471"/>
        <property type="gene ID" value="ERS852471_02595"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1115239at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO91471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="427" mass="44284" checksum="12AC7A43B16B9B45" modified="2016-09-07" version="1">MAQITEKLTTEKSSVRKVTEGLMNGVLAIQHLIAMFGATVLVPILTGLDPSVALFSAGIGTLIFHACTKGKVPVFLGSSFAFIPVIVAVGAQFNGDLRYAQGGMVIVGLIYIALSFLIKKVGLDKIRKVLPARVVGPMIMVIGLNLIPTALDMAGVNSLAAGQAGAVTTVMVAIVTLAVTLIIKTFGKGFLKQVAILIGVAVGYCISLVLNLVDVAAIQNASIIAVPNFTLPKFDMAAILIVVPVVLAVVMEHVGDITTNGEVVGKNFVEDPGLNRTLLGDGLATLAASFVGGPANTTYGENTGVLAITKNYNPAILRLAAVFAIILSFVDKVGAAIRTIPSSVMGGISLMLFSMIAIVGVQTIKREKVKLNIVNLIIMGTILLIGLSGNIFGKAIGIQITEAVSISGLSLASIVGVLLNVIVSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J2P4</accession>
    <name>A0A174J2P4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267299.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94004">
        <property type="protein sequence ID" value="CUO94004"/>
        <property type="gene ID" value="ERS852471_02653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO94004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="137" mass="16196" checksum="0A116A9E384C20B9" modified="2016-09-07" version="1">MIKGIIFLIMLLNFCNVPYTSEYEEKVESSFNMNEYYSPKEVIKIDEILEDKSGSLSEQEKEALIELKDKLNSYQALSQEDIDFIRDCDLKIIRSKLGDAKFEEYFKLISKRATKEEFSQDERLRLFQLEKEIKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J4P5</accession>
    <name>A0A174J4P5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO92059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267221.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO92059">
        <property type="protein sequence ID" value="CUO92059"/>
        <property type="gene ID" value="ERS852471_02610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO92059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="147" mass="17532" checksum="38E4091E0F3DA590" modified="2016-09-07" version="1">MLKRKFTTIILILLIIESFSFFNPFLKPNASFNLPCTCDDEFNSFYTDDDSSNSKYIDIFWTENNIKLLNENEKKILDDIQNKMITNNRLDKEDIEQMATLKDIVFKSKLTEDEFNDFKEIISKKRNREKLTTEEVVRLKSYFNSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDL2</accession>
    <name>A0A174JDL2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal-transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccpN</name>
        <name evidence="3" type="ORF">ERS852471_02734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267452.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97804">
        <property type="protein sequence ID" value="CUO97804"/>
        <property type="gene ID" value="ERS852471_02734"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016842">
        <property type="entry name" value="UCP026546_HTH-CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026546">
        <property type="entry name" value="UCP026546_CBS_YqzB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="23395" checksum="9BF88601B2441EB0" modified="2016-09-07" version="1">MKLTSRQEEIIRLVKEGQPVTSEALASKLGVTRAALRADLAILTMIGILDARPKVGYVYVGRKLNSDILDNLSNIKAETIMSKPATVNEATTVYDAIVFLFLNDIGTIFVENNDVLVGAVSRKDFLKIAIGGTDIHKVPVGVIMTRMPNIIYGFQEDSAYSLAKKIIEHEIDSIPIVEKIEDSSKEKDEYKIVGKISKTNITKLFVKLGENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JJU6</accession>
    <name>A0A174JJU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267430.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97359">
        <property type="protein sequence ID" value="CUO97359"/>
        <property type="gene ID" value="ERS852471_02723"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="114" mass="12804" checksum="3F6A5D56746F92A2" modified="2016-09-07" version="1">MEDCIFCKIIKGEISSKKIYEDDKVLAFYDISPEAPVHFLVIPKEHIVSANEINEKNCEIVAHIFLVINKITRELGIDKSGYRIVNNCGEDGGQTVGHMHFHILAGRGLQWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JMH8</accession>
    <name>A0A174JMH8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative restriction endonuclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267567.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00922">
        <property type="protein sequence ID" value="CUP00922"/>
        <property type="gene ID" value="ERS852471_02802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP00922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="19790" checksum="B6A61F7A2F4AC31B" modified="2016-09-07" version="1">MSFNNVYFFIIIIFFCPLIGKIIFEALELYNLSKEYKNGNSLINSLIRLTAKEFQIWCGEYLVYLGYSNIIFSDVSNSNSSIICTLDNTSYYVYCKKTPKENMVSEFELESLLGILISKSLYNGILITTSPLSSKALDFLKNLPHPYTIKILSLDTIIEKDLGTYPLQLNNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JP70</accession>
    <name>A0A174JP70_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-methylgalactoside transporter inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mglC</name>
        <name evidence="7" type="ORF">ERS852471_02756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO98965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267578.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98965">
        <property type="protein sequence ID" value="CUO98965"/>
        <property type="gene ID" value="ERS852471_02756"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030158">
        <property type="entry name" value="MglC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF18">
        <property type="entry name" value="PTHR32196:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO98965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="37089" checksum="991A40F9E7C6F3D4" modified="2016-09-07" version="1">MEKIKEQNKTKKLNLEDFLLNYALYIVLFIMIVVFIIKEPTFLSINNFTKILSQASTRGILALGVAGLIVLQGTDLSAGRILGLTAIVSASLLQSTSYASRMYPNLPMLPLILPLIAAVIIGGIFGAINGFGVAKLKVHAFIITLGTQLIAYGISCLYIDRPPLGAQPIANLDERYTELVNGYFKIGTIKLPYLIFYLAIAAIVMWFIWNKTKLGKNMFAIGGNPEAAAVSGVNIVKNIMFIFIISGVLYGIAGFLEAARAGSTSTMTGFNYELDAISACVVGGVSFSGGVGTIPGVLIGAILLQVINYGLNFVGVNAYWQYIIRGLIIIIAVSLDVRKYLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPV1</accession>
    <name>A0A174JPV1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acyP</name>
        <name evidence="8" type="ORF">ERS852471_02772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267512.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99658">
        <property type="protein sequence ID" value="CUO99658"/>
        <property type="gene ID" value="ERS852471_02772"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO99658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10399" checksum="F47739F50750D2D5" modified="2016-09-07" version="1">MIRYHVILDGRVQGVGCRFFCQMNATSLSLTGWVRNLDNGMVELEVQGDEKSVDKYISIISKGNRFIRIDDYSIKKKDIVSNERSFKTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQC8</accession>
    <name>A0A174JQC8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">potA_2</name>
        <name evidence="8" type="synonym">potA</name>
        <name evidence="10" type="ORF">ERS852471_02776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267520.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99838">
        <property type="protein sequence ID" value="CUO99838"/>
        <property type="gene ID" value="ERS852471_02776"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO99838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="39075" checksum="F4454A76DD49C624" modified="2016-09-07" version="1">MSQNIIELKEISKTYGENKVLNNLSLNIKKNEFLTLLGPSGCGKTTTLKIIAGFENADEGVVLFADENITNLPPYKRKLNTVFQKYALFPHMNIYENIAFGLKIKKLPKNEIDKKVKEMLKLVALEGFEKRSVESLSGGQQQRVAIARALVNEPEVLLLDEPLGALDLKLRKEMQIELKKIQQELGITFIFVTHDQEEALTMSDTIVVMNKGVIQQMGSPEDIYNEPANAFVADFIGESNILDGIMLEDYKVEFSNVIFQCVDAGFDKNEKIDVVIRPEDIEITSPESGMLQGKVNTVTFKGVHYEIEVEEKNQKWIIHNTKSAVVDSMVGLNIDPEAIHIMRKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JTR4</accession>
    <name>A0A174JTR4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">nnr</name>
        <name evidence="9" type="synonym">nnrD</name>
        <name evidence="10" type="synonym">nnrE</name>
        <name evidence="13" type="ORF">ERS852471_02841</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267647.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03173">
        <property type="protein sequence ID" value="CUP03173"/>
        <property type="gene ID" value="ERS852471_02841"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="130"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="410"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP03173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="498" mass="54709" checksum="D8508658041AD10E" modified="2016-09-07" version="1">MYVMSRDGCKMIDKKAIEIVGIPSIVLMENAANEVFSKIKDLGQSFTVICGTGNNGGDGLAIGRKLVLAKREVHFVIISPRENYSNDFNVNYNIIDNMNCKISFIKDISDIHNLKEIINFNEIIIDSIFGIGINKELNEFYKEVIKVINDSKKYIIAVDVPSGLDCNTGNPMGGAVKASTTYTFEVVKLGFINYNSFKYLGNLEVIPIGIPNEIKDIINEGVTILEDYYYRDIIRKREIYGHKGDYGRAIIFAGSKGFTGAAYLATKACLKTGAGLTTLITPKDIQDILSGMLIESMTSNFNEEEKVDKLISTANAIAYGPGLPSSKEYEDFLLYISKNSSCHLVIDAEGINILSRRPEILDRLKGRMILTPHPGEMSRLVGKSISEVESDRINIAKEYAKKYKSIVLLKGYNTVITDGEKTYINTTGNSKMAAGGSGDCLTGMIVSLLAQKHSPLESALIGAYVHGKAGEIAGKYKYSVTASDIIDNISTIIHNIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JVJ1</accession>
    <name>A0A174JVJ1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02226">
        <property type="protein sequence ID" value="CUP02226"/>
        <property type="gene ID" value="ERS852471_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP02226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="445" mass="49113" checksum="5908F7DF49292849" modified="2016-09-07" version="1">MILDYLMKPGARIKRWVLLGFVGTILLALGVGEVFIHKEYDLTRKMVCIFLGLLGVVVIVISISEGLKSILRLINSDKINITINDKNVEDLIDDERLSVSGPKIVVVGGGTGLSTMLRGLKNYTNNITAIVTVGDDGGGSGKIREDFGMLPPGDIRNCILALADTEPIMEKLLQYRFKEGSLEGQSFGNLFLAAMAGISDNFEEAVQRMSSVLAVTGKVLPVTLDDMKLVAILENGDEIDGESRIPDEAIARKSKIKKLMINPENAKPLVDALKAIEEADAIIMGPGSLYTSIIPNLLVTDIADTICESDAIKIYISNIMTQPGETDDFTAADHLKTLINYGGKKCVDYVIANNGTIPDDIKERYLKEGSKLVELDRDNIKGLGVEIVEENLVKITKGYVKHDSEYLADIIMKTVIEKELKWDKEKILEYVYSLQKMREKRNTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K990</accession>
    <name>A0A174K990_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267760.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05829">
        <property type="protein sequence ID" value="CUP05829"/>
        <property type="gene ID" value="ERS852471_02904"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074570at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP05829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="49676" checksum="39C9AEF52E821973" modified="2016-09-07" version="1">MNKRKIALPPIGMRIIKSSIGVLLGFIIYFLRGKQGTPFYTALSVLWCMQPYSSNAKANAIQRTIGTFIGAAYGLIMILVELYVIPFDNELFRYITISLLIIPIIYTTVIFNKKNASYFSCVVFLSIVVNHLKDKNPYLFVFNRMMDTMIGIGLALIINTFELPRKRRNDLLFVAELDKVLLNMKETLTSYSKIELNKMLDDGVKLTIATMKTPGALVTSLQDIRLNLPVIAMDGAILFDMKENKYLKVYEMTHEETKKLVDLIQARNMHCFINTVVEDSVMIYYGDFKNPVESDIYNNLRSSPYRNYIKEELPDRYGAVYLMLIDETEKIESLYEELERLGYTKEFKVLKYDSDDYPGYTYIKIYNKKAIKENMIKYVQSLTDAKSTLVFEKDNEVFQNYISKNDPNEVVKKLRKIYRPYFWHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KD76</accession>
    <name>A0A174KD76_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267811.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07260">
        <property type="protein sequence ID" value="CUP07260"/>
        <property type="gene ID" value="ERS852471_02932"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1959995at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP07260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="71" mass="8272" checksum="59A8F86DE61A4EA0" modified="2016-09-07" version="1">MKVKIVCTRDNETKIVDLPMNEEELLKIQGSVLDRDTVGYITGAEIKYYDENLNEIDNVFLLNRQLKNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KF51</accession>
    <name>A0A174KF51_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdhA</name>
        <name evidence="3" type="ORF">ERS852471_02947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267892.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07869">
        <property type="protein sequence ID" value="CUP07869"/>
        <property type="gene ID" value="ERS852471_02947"/>
    </dbReference>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004642">
        <property type="entry name" value="Ser_deHydtase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00718">
        <property type="entry name" value="sda_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="294" mass="30304" checksum="0A899D8714E5816F" modified="2016-09-07" version="1">MIANSGKELIEICEKEQISLSEYAIRKEMECKGVSREYLFEQMKLTLDAMKESATVGREKQVYSLSGLIGGDAYRLQQYSNSGKSLMGSGIVTAMAMAMSSSEVNGAMGKIVACPTAGSCGILPAVILSAGELLNKTDEELIQGLFASSAIGMIIGMNATFSGAEGGCQAECGSAAAMAAGAVVELMGGTPKMSLDAAAIIFKNVLGLVCDPVAGLVEIPCAKRNVSGAISALCTADMVMAGVDSKIPFDDAVSAMYKVGTSMPAELRETALGGVAITETGLALKEKVFGKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KG70</accession>
    <name>A0A174KG70_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267896.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09466">
        <property type="protein sequence ID" value="CUP09466"/>
        <property type="gene ID" value="ERS852471_02974"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879568at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010380">
        <property type="entry name" value="DUF975"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40076">
        <property type="entry name" value="PTHR40076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06161">
        <property type="entry name" value="DUF975"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="207" mass="22934" checksum="6BD3F17DD9303016" modified="2016-09-07" version="1">MERSELKFRAKEQLRGNWGIAIGAVLLAAIFTDFDVIYNIGERFGLDGLTFSVPVNLLSLFLGGVITTGLCKLLLNLATNIEKPKVENLFSYFNIYLKTLGLNILISLAVAIGTILFIVPGIIVALMFSQAFFILAEDSSKSITQCLSESTEMMKGYKADFFVLELSFIGWWIVAALTLGIGGLWVAPYQKLTEANYYLSLKGNKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KH91</accession>
    <name>A0A174KH91_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate reductase, catalytic subunit</fullName>
            <ecNumber evidence="7">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">narB_2</name>
        <name evidence="7" type="ORF">ERS852471_02991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267929.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10141">
        <property type="protein sequence ID" value="CUP10141"/>
        <property type="gene ID" value="ERS852471_02991"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="691" mass="77542" checksum="57E9F68115B40AEB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KHG0</accession>
    <name>A0A174KHG0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sodA</name>
        <name evidence="10" type="ORF">ERS852471_02986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09916">
        <property type="protein sequence ID" value="CUP09916"/>
        <property type="gene ID" value="ERS852471_02986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026149" description="Superoxide dismutase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_N" evidence="8">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="9">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP09916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="235" mass="26903" checksum="1C684FB176C1C09A" modified="2016-09-07" version="1">MKKFLTFLCLFLTFFSLTSSICYGEELEKNKFTLNPLPYEYDALEPYIDKETMIIHHDKHQKAYVDNLNNAISKYPELYSKGLEGLLTNVDSLPSDVKQAIINNAGGVYNHEFFWSIMAPEQPGVPMGNLAKAISKTFGTFDDFKTRFKIAALNRFGSGWAWLVSDKEGNLSIISTANQDTPITQGLIPIIGVDVWEHAYYLKYQNRRGEYIDAWWNTVNWEQAERNYNAVAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLX4</accession>
    <name>A0A174KLX4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic sulfite reductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrK_4</name>
        <name evidence="3" type="ORF">ERS852471_02993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267933.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10209">
        <property type="protein sequence ID" value="CUP10209"/>
        <property type="gene ID" value="ERS852471_02993"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014260">
        <property type="entry name" value="Sulphite_reductase_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02911">
        <property type="entry name" value="sulfite_red_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP10209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="264" mass="29807" checksum="BD23562B69382B70" modified="2016-09-07" version="1">MENLYIPKRTKILKIIKHTDKEWTFRVYANSKDVRPGQFYEISMPKHGESPISVSGIGENTLDFTIRAVGKVTDEIFKLEEGDNLLIRGPYGNGFDVNQYKDKEIIIVSGGSGLAPVRGIIEYFYNNYDECKGLTLICGFRSPNDVLFVEDIRRYDDKMNVILTVDGADSNYDGNIGLVTKYIPELKIKNIDNVAGIVVGPPMMMKFAIIELQKLGIKDEDLWVSYERKMSCGLGKCGHCKMDSTYICVDGPVFNFSFGKTLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQI9</accession>
    <name>A0A174KQI9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">murR_4</name>
        <name evidence="2" type="ORF">ERS852471_03047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268037.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12716">
        <property type="protein sequence ID" value="CUP12716"/>
        <property type="gene ID" value="ERS852471_03047"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP12716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="282" mass="32773" checksum="CA88749BA3BCDF75" modified="2016-09-07" version="1">MNIFTQLRNTKNLTNNEKQIVDFILDNPNAFLNMSSEQICKECFVSTTTLYRLCQKFNLSGLSDLKVKMSGSINSYLKENKDFDFDFPVKQNQSHYEILTKIREDYDQTLLSTFNLFNLEQLRLSVNAMKKAKQIDVYTSAGNIFFAENFKFQMQEIGITINVPEEEYNQRLVASCSDENHLAIVISFGGRGLLVNKIIKTLKGNKTPILLISSTEDSPIKEYADYQLYLCSNENHYNKISSFSTRLSLLYILDILFACYFKTDYDKNLEKKLNYYKKMIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KRK0</accession>
    <name>A0A174KRK0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">polA_2</name>
        <name evidence="3" type="ORF">ERS852471_03065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268071.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13471">
        <property type="protein sequence ID" value="CUP13471"/>
        <property type="gene ID" value="ERS852471_03065"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="375"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="653" mass="74821" checksum="5B75B4B4D1D23C5D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KSK7</accession>
    <name>A0A174KSK7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268085.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13841">
        <property type="protein sequence ID" value="CUP13841"/>
        <property type="gene ID" value="ERS852471_03072"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="224"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP13841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="430" mass="49174" checksum="5AC3754604C97619" modified="2016-09-07" version="1">MERKILKWLINWKNSSNRKPLILQGARQVGKTYSALTFGKEYYDSVVYFNFENNRELIKIFERDLDPERIVRELSINAGKSIFKEKTLIFFDEIQACERALTSLKYFNENANEYHIIAAGSLLGVAVNREQYSFPVGKVDLKTLYPLDFEEFLMAMNEKDLINIIKECFNNDTELSLHNKAMDIYREYLVIGGMPAVVKEYIEKKDFDFVLATQKGINDSYVADMAKYATPNETTRIMATFNSIPAQLAKENKKFQYKVIKSGARAHEYETPVEWLKSSGVILKCIKCNEGKLPLSAYSDFNSFKVYMTDTGLLCSKFGIPANAVLSEGVVFNDFKGALTENYVCFTLNANGYIPYYWESKGSAEVDFLIQDKDGNIIPIEVKAAEHVRAKSLQQFIKKYQPKYAIRVSAKNFGFENGIKSVPLYAAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTW4</accession>
    <name>A0A174KTW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12935">
        <property type="protein sequence ID" value="CUP12935"/>
        <property type="gene ID" value="ERS852471_03052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="32" mass="3818" checksum="DFE98ED72A501C08" modified="2016-09-07" version="1">MEEKLKSVCWFFAGVLCYFIVSKIIELYCIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L3Q1</accession>
    <name>A0A174L3Q1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yheS_3</name>
        <name evidence="5" type="ORF">ERS852471_03124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16758">
        <property type="protein sequence ID" value="CUP16758"/>
        <property type="gene ID" value="ERS852471_03124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="356"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP16758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="536" mass="61909" checksum="C6042A9E3B8E0D11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L951</accession>
    <name>A0A174L951_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sucD</name>
        <name evidence="3" type="ORF">ERS852471_03174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19401">
        <property type="protein sequence ID" value="CUP19401"/>
        <property type="gene ID" value="ERS852471_03174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07121">
        <property type="entry name" value="ALDH_EutE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012408">
        <property type="entry name" value="Acetald_propionald_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036410">
        <property type="entry name" value="EutE_PduP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="57"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP19401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="490" mass="52448" checksum="9E3B3236A002042B" modified="2016-09-07" version="1">METSTELVQEIVAKIMKKMSKTEVVADKKCGCNGGCGGNGSCKGDGSCKSHEDYIFSDVDSAVAAAKEAYKKLKNLSIKDREKIIQKIREKCLTYAERLSMMAVDETGMGRVEDKITKHLLVAEKTPGTEDLTTTAWSGDGGLTLVEQGPFGVIAAITPSTNPTATVFCNSIGMIAAGNTVVFAPHPGAKECSKFAVKLVNEASIEAGGPKNIVVTFDNPSIEITSALMNHKDVPFISATGGPGVVKQACSAGKRAIGAGAGNPPVIVDETSDIKAAARDIIDGATFDNNLPCIAEKEVVAVEQICDELIVEMQKNGAYLLEDPELVKKLVDTVLIKKGDKRILNRKFVGRDAKVILDAIGVYAEDSVRCIIFKGCKKHLLVVEELMMPILGIVTVKDFEEAVEVAVELEHGNRHSAHMHSKNIDRLTYFAREVDTAIFVKNAPSYSALGVGAEGYPTFTIASKTGEGLSSAKTFTKARRCVLKDSLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LA00</accession>
    <name>A0A174LA00_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccmK2_1</name>
        <name evidence="4" type="ORF">ERS852471_03176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19506">
        <property type="protein sequence ID" value="CUP19506"/>
        <property type="gene ID" value="ERS852471_03176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026797" evidence="2">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="BMC" evidence="3">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="10380" checksum="CEA679CDF2C2D94C" modified="2016-09-07" version="1">MKALGLLEVFGLTTALVAADAACKAGDVRVVTIDKNKPGNADKLEVPLLIVIKFEGTVSDVEMAIEAGIAAANKVSGVSCSYVIPRVDEGIKGFVDTSCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LBG1</accession>
    <name>A0A174LBG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268342.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21824">
        <property type="protein sequence ID" value="CUP21824"/>
        <property type="gene ID" value="ERS852471_03221"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1869225at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP21824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="433" mass="50375" checksum="6B97BE7BC95C636C" modified="2016-09-07" version="1">MEILSLGEKIKRKRKELNMTLKDLAADRITPGQISLVESGRSNPSMDLLEYLAENLQTTVEYLMESEESQAEKICVFYEKTAESYVLSGDFISAEKYIENALYYAEKFGLEYRKARNLYIRADIAMKNGELALAQQIYLSANVIFIKQNKYEEVTRTFLNLGKITLKLKAYHSATSYLRQAEKVYLDNKIGDDLLLGEIYYQMAEGYFKIDNITKAMNYSFLAKEKFEQVYDEEKYAKTLLGISEKYSENGDLSNAIKYSEKALEVYKDLNKGSHIAYIENNLGRLFYEFENFEESFKHLEIAKDLRSRKKDQSVVETLFNICENYIKLKDIEKCETTLKEINHVIDENFVENVIEYNLLWYRVYTIKEMYKEAENILIDTFNLAKANELSKKAAQVAIMIGKFYIDWKQDSEAAKYLDQGVSILKELGVLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LGK7</accession>
    <name>A0A174LGK7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDGSH-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032592430.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20609">
        <property type="protein sequence ID" value="CUP20609"/>
        <property type="gene ID" value="ERS852471_03199"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667004at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="147"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP20609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="39581" checksum="21FAF4A44077D59C" modified="2016-09-07" version="1">MATISNIKSDITSLSEYQLRELFNYIGEMLTLGSSNGSLNKEFRESRFSKGQCCPHCESTSVVKNGKLKGKQRYLCHSCKKSFNDLTKSALSCTKLPLQTWIEYVKGMIIGFSIRKNAENVGVCVKTSFYMRHKVLDCIRAFMGVGDVDGIVEMDETFVAESFKGNHKKSGFKMPRPARKRGKQIKKRGISNEQICIATAIDRNGNIILEPLCKGRVTYNALERLYEGRIDSTSIICTDSHKSYIQFAKDLQLDHKRIARGHYKNDIYHINHVNSLHSNLKIWMYRFKGVSTKFLNNYMSWYKWLQSFSSDKEVIKTKNMLIHSIIPFVDTKIKGYKERETNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M0U6</accession>
    <name>A0A174M0U6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000043">
        <property type="protein sequence ID" value="CUP27409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268487.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27409">
        <property type="protein sequence ID" value="CUP27409"/>
        <property type="gene ID" value="ERS852471_03311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP27409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="9300" checksum="B6C23205BB1A538B" modified="2016-09-07" version="1">MNDNLKLYRCVFLKENNEFIIGKDIFNEKVYHIRKSEETEGFKIGTDNSFYAEKEMKGILFKKNILKVINYNKVIEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XF75</accession>
    <name>A0A173XF75_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadmium resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262712.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50441">
        <property type="protein sequence ID" value="CUN50441"/>
        <property type="gene ID" value="ERS852471_00031"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1869757at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004676">
        <property type="entry name" value="Cd-R_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03596">
        <property type="entry name" value="Cad"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN50441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="228" mass="25565" checksum="530C9237CEEE5B1B" modified="2016-09-07" version="1">MFGTILTALTSFVATNIDDIFVLMLFFSQINNSMKTRHIIIGQYLGISALIAISIIGALGISIIPNEYVGLLGLAPIYLGINEYIKYKKERKDIESTEDQENRISKNNNLEKTTENDDNSITKVIKSLINPSVFKVASVTLANGGDNIGIYIPLFTSMNSMDIFITVVIFILLIALWCYIGKSLSEYPFIQRNIEKYKHIIIPIIFIGLGIFIIIKSGTIPLIYKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XS28</accession>
    <name>A0A173XS28_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262829.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54080">
        <property type="protein sequence ID" value="CUN54080"/>
        <property type="gene ID" value="ERS852471_00099"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2114497at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="276" mass="31740" checksum="CFE529C22EBF4C19" modified="2016-09-07" version="1">MKCKYSKNRSDKEKFKHISDNDKNALELLHLQLIFIYIYMMSDVFLFIGTIESINICYGKKEDNNPILLLEQGQILALIANIINNYITSTRYSQLSERYNEEEISLEPEFLVKQASILSIILYSLNVIAVSKQYEASLVINIFKCDKNSINLLFLQAVCFLMRFYGDYFLLRSTLKSIDLIRSKYDKSIKKIYNPDIDAVIAAEFYVLQRGVLYDIGCIALVTLINNGTELEKELLLPAQQTLVIANIIGVIANITVLIAFIKIYNRNENEPIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XVX8</accession>
    <name>A0A173XVX8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adhR_1</name>
        <name evidence="3" type="ORF">ERS852471_00109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN54538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262847.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54538">
        <property type="protein sequence ID" value="CUN54538"/>
        <property type="gene ID" value="ERS852471_00109"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN54538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="128" mass="15088" checksum="12361B528786E53A" modified="2016-09-07" version="1">MTITEVSRKYNLTADTLRYYERIGLIPPVNRNNSGVRDFTEEDCNWVQFIKCMRGAGLSIEVLIEYVKMFQEGNSTIKARKELLIEQRNHLADKIKEMQETLDRLDKKIDGYEERVLIKEQELSKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWM9</accession>
    <name>A0A173XWM9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exonuclease</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dinG</name>
        <name evidence="6" type="ORF">ERS852471_00145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262912.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56341">
        <property type="protein sequence ID" value="CUN56341"/>
        <property type="gene ID" value="ERS852471_00145"/>
    </dbReference>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="248"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN56341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="982" mass="115807" checksum="C4E68C87D1E7D83B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XYS3</accession>
    <name>A0A173XYS3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">nusA</name>
        <name evidence="9" type="ORF">ERS852471_00155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262930.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56804">
        <property type="protein sequence ID" value="CUN56804"/>
        <property type="gene ID" value="ERS852471_00155"/>
    </dbReference>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NusA_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="KH_5" evidence="8">
        <location>
            <begin position="233"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN56804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="352" mass="38987" checksum="FC728C0A6AA72AE3" modified="2016-09-07" version="1">MNEEFIGALREIVKEKGISEDLLFETIEDALEAAYKKNYAGPNSAAANVKVTINRDNGEIHVYSQKIVVEEIFDNVTEISIEEAKELNPKYDLNDVVDFEVTPKNFGRVAAQLAKGVVTQRIREAERSIIYNEYKEKEYDIITGTILRKDKGNVFVNIGKLETAIGPNEQMPGEIYKFPEKVKLYVVEVKNTPKGAQVVVSRTHPGLVKRLFELEVPEIHEGVVEIKSISREAGSRSKVAVVSHDENVDPMGACVGPKGARVQNIVNELKGEKLDIIKWSKDPEEFIASALSPAKVLSVDVDEENKSAKVVVEDNQLSLAIGKEGQNVRLAAKLTGWKIDIKSKSQAEASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3E1</accession>
    <name>A0A173Y3E1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262970.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57766">
        <property type="protein sequence ID" value="CUN57766"/>
        <property type="gene ID" value="ERS852471_00175"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1757306at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="321" mass="37102" checksum="FE06327C89E96F84" modified="2016-09-07" version="1">MTYDVKPILVISKCLGFDACRYNGGIENNSFIENLKKYVEFITVCPESDSGLSTPRDILRIVQKNDKLEIVVSKTGEDVTGKLCDFIEKFLTDLGDVDGFILKNKSPTCGLKDAKIYTSVDKGAAIRRGKGIFVKKVSNKYPNIIIEDEGRLTNFKIREHFLTRIFVLANFRNAKKSNDKDMLRNFHLQNTLLFLAYSQKYSKLLDSLIYNDESFNSNTVFIEYEKYLNKLLERAPRYTSNINVLLKSVDSFKDNITQDEMQFIWNTIDKYKKGLVPFSVPLYLVKGYIVRFDLEYLLNQSFFMPYPEELIHVSDSGKLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSC6</accession>
    <name>A0A173YSC6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263223.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66440">
        <property type="protein sequence ID" value="CUN66440"/>
        <property type="gene ID" value="ERS852471_00301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1857894at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041301">
        <property type="entry name" value="PBECR3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18812">
        <property type="entry name" value="PBECR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBECR3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN66440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="133" mass="15537" checksum="7485CB2A7572D283" modified="2016-09-07" version="1">MNSRFCTYKRVGYLRRSVADELGIEFTGAIYACPGVLKHIIKRHGKQLDKNIKKNIFEFMKVILEEPDYIGLYKSEEGTTSIQFVKKMYNYLLLGVEVDEMNQYIYVSTMYPINDNKIKNRLDYGELIKVNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YU70</accession>
    <name>A0A173YU70_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fmt</name>
        <name evidence="11" type="ORF">ERS852471_00311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263241.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66997">
        <property type="protein sequence ID" value="CUN66997"/>
        <property type="gene ID" value="ERS852471_00311"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN66997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="308" mass="34160" checksum="3B72DB385B9FC978" modified="2016-09-07" version="1">MKIVFMGTPDFAVPSLEKIISKYGVEAVFTQPDRPKGRGKKMAYSPVKEVAVKHNIKVFQPEKLKEDREAIEYLKDLKPDFIIVVAFGQILTKEVLDIPSIGCINLHASLLPMYRGAAPLNWVVINGEKVSGNTTMLMDVGLDTGDMLLKDEVEITENMTAGELHDKLMISGADLLIKTIEGMSKGEITPIKQEGETCYAKMLNKDTGKIDWEKSAKDIHNLIRGLNPWPIAHTTYKGESMKIYESIVINENSSKEPGTIISVNKSGMKVNTSDGIILIKKIQFPNGKPLTIEQYINGKEIEVGTKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVL7</accession>
    <name>A0A173YVL7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN67567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263259.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67567">
        <property type="protein sequence ID" value="CUN67567"/>
        <property type="gene ID" value="ERS852471_00321"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1961470at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="12914" checksum="3EB898FE5FCA60F6" modified="2016-09-07" version="1">MVGYVNNLGNIRYSEEVLAKIVGLSTMECYGVVGMVSKNATEGFWELIRVENLSKGVKLKFNDDDKLEIELFVMVEYGTKISVIANNIIQKVRYSVENYTGLSVASVTVNVQAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0M0</accession>
    <name>A0A173Z0M0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplS</name>
        <name evidence="8" type="ORF">ERS852471_00346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263299.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68986">
        <property type="protein sequence ID" value="CUN68986"/>
        <property type="gene ID" value="ERS852471_00346"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="13450" checksum="A132E65B53A74EC5" modified="2016-09-07" version="1">MNEILRAIEAEQIRTDLPNFRVGDNVKVHVKVKEGNRERIQVFEGTVIKKQNGGLRETFTVRRVAYGVGVERTFPMNAPIIEKMEITRRGKVRRAKLFYLRDRVGKAAKVKELLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8M9</accession>
    <name>A0A173Z8M9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopropionate ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dpaL</name>
        <name evidence="4" type="ORF">ERS852471_00405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.3.1.15" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263407.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72257">
        <property type="protein sequence ID" value="CUN72257"/>
        <property type="gene ID" value="ERS852471_00405"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008838">
        <property type="term" value="F:diaminopropionate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010081">
        <property type="entry name" value="DiNH2opropionate_NH3_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019871">
        <property type="entry name" value="DiNH2propionate_NH3-lyase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03528">
        <property type="entry name" value="2_3_DAP_am_ly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01747">
        <property type="entry name" value="diampropi_NH3ly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="404" mass="44645" checksum="C4241E213AE9CA51" modified="2016-09-07" version="1">MRGKIKWKVNTLPHNKEEIDLEFLSEKEIRKAREFHSSFPQYKETPLVALDKLSEYLGLGGIYIKDESYRFGLNAFKVLGGSFAMAQYMAQRLGKDISELPYEKLISDEVRKELGDITFVTATDGNHGRGVAWTANKLRQKSVVYMPKGSSLTRLENIRKEGADASITDMNYDEAVRLAAKYADEHNGVVIQDTAWDGYEDIPAWIMEGYGTMGLEALNQLRSYGVERPTHIFLQAGVGSLAGGIQGFFASIFGDDCPKTTIVEASEAACLYKSAVANDGNLRVVDGDMPTIMAGLACGEGNTIGWKVLKNYSKLFVSCPDYVAANGMRILGNPMKGDTKVVSGESGAVTLGLIYEIMTNTEYKELKDTLGLDENSKILLFSTEGDTDPDKYKKIVWEGEYGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHH6</accession>
    <name>A0A173ZHH6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263495.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74668">
        <property type="protein sequence ID" value="CUN74668"/>
        <property type="gene ID" value="ERS852471_00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="135" mass="15602" checksum="A54089A38FBEC653" modified="2016-09-07" version="1">MNESTWYRIKYSIGYVFEENKLVIAIPVGILDSTKENFEKNIKLMDIGPYIALPSEAISIGESCRDNISRILNETLEDAIIIIDKIIDGKTGEDLEEICTKAKDMYDSEKIYLEKGYILKNIDEFNENIDQYNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9G2</accession>
    <name>A0A174A9G2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">arlS_1</name>
        <name evidence="8" type="ORF">ERS852471_00560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263699.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84176">
        <property type="protein sequence ID" value="CUN84176"/>
        <property type="gene ID" value="ERS852471_00560"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="195"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="413" mass="47147" checksum="2BFED563C5A0CC3C" modified="2016-09-07" version="1">MMKKDIFLKTKRKVIILSLSIVFICLLIFAIITKTLYTSIVFSHIDQQLMNERNTYSNAMNTGRDVREWRGIPKLPPNIIMIIQTGNGVALMNQNYYFDSDNLPVFPDNSEDEIVTLTFGEYTFRGIKFKFNDLVVSLLINVDSEIQSVNQLMSSIILSFVILIIIALVLSYYLSSKIMKPVKEAYDKQVFFVQDASHEMRTPLAVIRGKLELLANKWGDTIDNNFEHISKMMSEVRGLEKLNSDLLLLSKEDVDGSINITEFSLNDFITDLSEFYIDLAEIQEKTFEVKTVDSDLKVSWDYNKIKRMIIILIENAFKYTGDNGKIQLSFEDAGKNIKVTVKDNGIGIKEEDQKRIFDRFFRSADVRVKNISGSGIGLSLLKSISKTLDIKVKLTSKELVGTEFTLLIPKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ABC3</accession>
    <name>A0A174ABC3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dedA_1</name>
        <name evidence="3" type="ORF">ERS852471_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263717.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84826">
        <property type="protein sequence ID" value="CUN84826"/>
        <property type="gene ID" value="ERS852471_00570"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="323"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN84826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="432" mass="48892" checksum="F8B67BB7F7D206F0" modified="2016-09-07" version="1">MERLAELINNYGYIIIFLSLFLELIALPLPGEILMGYCGFLIYNGSLNYTLSIITAALGAICGITLSYFIGKLLGVPFFHKYGKYVHLTPEKLDKISGWFDRFGNKLLTIAYFIPGVRHITGYVSGITNISFSKFAIHAYIGAFIWAITFITIGKALGEDWNYLHKYATKYLIIGAILLGIIIVAIYGYKRYEKEIKKYIYLYMKNIISVYNSIKKVELGIVIAGIVYIALIIVTFKLIDEHLSNEMSLFDSITYRIFRGVFSKSFIEVISGFKNLSSVYIVILVSILMVGWITVKQSQKVKNILFIIFTILGGEIFVDISNYIFKKSNSAIDIGSIYNSFPSKDVFIVSILFGIITYYILRQSYSKIIKTISMIILISICAFVGISDIYLKIQYASGVIVAYLFATLWIILCITILELWSIIPEVASKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ABF2</accession>
    <name>A0A174ABF2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263737.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85523">
        <property type="protein sequence ID" value="CUN85523"/>
        <property type="gene ID" value="ERS852471_00580"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="145" mass="16966" checksum="97889133DAB6294F" modified="2016-09-07" version="1">MDTNFKISNILYNMKHIGDLYYDLSSKAAKECNLTKPEADILLFIKNNPEFNTAKDIVKLRGFSKAYVSKAVEPLLDKELITIEIDKEDRRCQHLLLTEKSEPLLDILLKMQREFIDIITDGIDKEDIKTYIKIMDSFYKNSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AG50</accession>
    <name>A0A174AG50_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263759.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86478">
        <property type="protein sequence ID" value="CUN86478"/>
        <property type="gene ID" value="ERS852471_00591"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1957125at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="241" mass="27692" checksum="9A32A994A39EEB3F" modified="2016-09-07" version="1">MDKSLRVAKFNIIDMRKRIIYFYLIISIVLMFFINIGQYGEILLPVIMDVLTFIFLLSCASDTLKNKFKFAQANNISRSTFIKGTIISIFPISALMAVIDFAINRTMNLFIKAPTFYDLYFTTFEKFTDVEGRIIWMQDGGLNAIIGSVLFSFMIYSLASVIGLIIGVINLKTSERTQLIWSVLSVGLWIVWFNIDDRFLILDKIRPSTDNRVFLVLLIYILVFGVCIFGSFKMIRKATVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIL7</accession>
    <name>A0A174AIL7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263783.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87375">
        <property type="protein sequence ID" value="CUN87375"/>
        <property type="gene ID" value="ERS852471_00604"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="22755" checksum="E16D2DCD4918AE5F" modified="2016-09-07" version="1">MKVLLINGSPNAKGCTYTALEEVSKTLNQEGIETDIVHVGNKDIRGCIACRQCRTKGKCVFNDIVNEVAPKLNECDGIVIGSPVYYASANGTLISFIDRLFYSSMSIDKRMKVGAAVVSCRRGGSTATFDEINKYFTISGMPIASSQYWNMVHGNSAEEVKKDLEGMQTMRTLGKNMAFLMKSIQLGKEQFGLPEKEAHIFTNFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AL44</accession>
    <name>A0A174AL44_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89164">
        <property type="protein sequence ID" value="CUN89164"/>
        <property type="gene ID" value="ERS852471_00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="154"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="468" mass="52013" checksum="771E4410FB456287" modified="2016-09-07" version="1">MMNYDVIIVGAGPSGIFTALEAKTLNPEKNILLIEAGRRIDKRSCPKEKTNVCVSCKPYCHITTGFSGAGAFSDGKLSLNYEVGGDLPELMGPSLVQEFIDYTDKIYLDFGADTKVEGVGNNEAVKEIRRKAIKGNLKLVDCPIRHLGTEMAQQIYLKIQNHLLELGVEIKFDTVAKNLIVEDNAIKGVLIADSRTKKIEEKVYADKVVVATGRKGADWLKDMCLEHNIDHRAGTVDIGVRVELRNEVMESVNDVLYESKLIGYPAPFHDKVRTFCQNPGGFVSQENYDNDLAIVNGHSYKNKKSENTNLAILSSHNFCEPFNKPIEYGKKVAELVNMLGNGSIIVQRYGDILDGKRTWEHELYQSNIKHTLPDAEAGDLTSAIPYRTMTNILNFIESMDVVVPGFASRETLLYGPEIKFYSNKIELDKNFETNIKGLYCLGDSSGWTRGLMMASAMGVMMGRNLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALL6</accession>
    <name>A0A174ALL6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">tal</name>
        <name evidence="10" type="ORF">ERS852471_00637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263844.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89344">
        <property type="protein sequence ID" value="CUN89344"/>
        <property type="gene ID" value="ERS852471_00637"/>
    </dbReference>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="215" mass="23418" checksum="4B53068E07623846" modified="2016-09-07" version="1">MKLFIDTAIVEEIKKANDMGVICGVTTNPSLIAKSGRDFKEVITEITNIVDGPISAEVVSTEAEGMVKEADELVKIHKNIVIKIPMTEEGLKATKILSSKGVKTNVTLIFSAAQALLAARAGATYVSPFLGRLDDIGMDGIELIKEIVEIFEIHDIKTEIIAASIRSPIHVTKAARCGAHIATVPYKVIIQMTKHPLTDIGIEKFLKDWEDVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANN5</accession>
    <name>A0A174ANN5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">greA_1</name>
        <name evidence="5" type="synonym">greA</name>
        <name evidence="9" type="ORF">ERS852471_00635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263840.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89220">
        <property type="protein sequence ID" value="CUN89220"/>
        <property type="gene ID" value="ERS852471_00635"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="7">
        <location>
            <begin position="82"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="154" mass="17270" checksum="0D9475848B0EFD81" modified="2016-09-07" version="1">MNNILTEENIKKLREELDYRMTVKRAEIAKDKLIAAAHGDRSENAEYKAACENYRENDNRIQYLLTMISTATVVDDSSLDKSVLGINSKARIRFIEFDDEDTITLTTTLDANPEDMLISIESDLGKALAGKKVGDIVEVNAPAENYSVEILEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATI5</accession>
    <name>A0A174ATI5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263904.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91827">
        <property type="protein sequence ID" value="CUN91827"/>
        <property type="gene ID" value="ERS852471_00673"/>
    </dbReference>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028212">
        <property type="entry name" value="GHL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14871">
        <property type="entry name" value="GHL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42M" evidence="1">
        <location>
            <begin position="378"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN91827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="667" mass="76941" checksum="9F799FAC2C451480" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AX50</accession>
    <name>A0A174AX50_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family 1 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852471_00676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263908.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91988">
        <property type="protein sequence ID" value="CUN91988"/>
        <property type="gene ID" value="ERS852471_00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018004" evidence="4">
        <location>
            <begin position="27"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN91988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="435" mass="48634" checksum="1393B7FF01C991CA" modified="2016-09-07" version="1">MRKKIIGLLLATMTMTSLVGCGSSSANSTTEEGGTITIKMLSRYSSDQGPDDITINKRIEEFMAENTNIIVEHEAIGDESTYNNMFKTSIATGDAPDVFVNYGGTQFKEYVESGLFYDLSKVAEEDTVWGDKYIESMLDALKYEGVEGYYGVPFSCFATGLYYNKELFEENGLEPPTTIEEFEKVCDEFLAKGITPFALGDKDNFRGAHLLANLVLKRDGFDYTKSIIDGETKWNDTAMKEVFELMNSWREKGYLGENITTLDSSGEQSLFLNGDTPMHLNGSWFMNQVNDSDNPERVGFIAFPYFEKYPENKNNWHSGTSEGFSLSATNGEERLQASIKLLKYLTDEEAYNESQALSKGGIYPVTTMKEIDDITPIAKEFQAAFTDVNEAKLEPGDYAAKAQLREEIRDAIQGMFAGTSVDDTLARIQKVTDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFU3</accession>
    <name>A0A174BFU3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">thiI</name>
        <name evidence="9" type="ORF">ERS852471_00776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264109.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99363">
        <property type="protein sequence ID" value="CUN99363"/>
        <property type="gene ID" value="ERS852471_00776"/>
    </dbReference>
    <dbReference type="OrthoDB" id="773697at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="57"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN99363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="385" mass="43786" checksum="49567C8347F05BAB" modified="2016-09-07" version="1">MNKLILVKYAPEIFLKGLNRGKFERQLMNNIKKRLDDIEYEIVVDQGRYFIKAQDVEAAVERVRKVFGVVEVCLVTEVKRDLTVIKEEVFKMVNEIKPRTFKIETNRANKKFPLNSIETSRDVGGYVLHHYGEGLEVDVKNPECLVNIEIREKGAYIFTSKDKIKAVGGLPYGINGSTMLMLSGGIDSPVAGYLMARRGVALNCVYYHSHPYTSERAKDKVKELARILSEYAEKVKLYIVPFTEIQMAIINGCREDELTIIMRRFMMRVACELAERNGIQSVSSGESIGQVASQTMEGLIVSTDCADRPVFRPLVTMDKTEIMDIAREIGTYETSILPYEDCCTIFVPKHPKTKPRLEDMRRAESVLDIEALVNKAIEETEIVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHD4</accession>
    <name>A0A174BHD4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspC_3</name>
        <name evidence="4" type="ORF">ERS852471_00797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264153.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00432">
        <property type="protein sequence ID" value="CUO00432"/>
        <property type="gene ID" value="ERS852471_00797"/>
    </dbReference>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO00432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="388" mass="43435" checksum="43B8D7D874454D1F" modified="2016-09-07" version="1">MILENMIRDDVKNMPPSGIRKYFDLINEMEDVISLGVGEPDFVTPWNVREAGIYSLEMGETHYSANAGFIELREEIAKYLDRKYDLKYNPKDEILVTVGGSEGIDLALRALVGPGDEVIIPEPSFVAYKGCTAFTGATAKIIDLKAEDDFKLTPKQLEDAITDKTKVVIIPFPNNPTGAIMTKEELAGIVEVLKNKNVIILSDEIYSELSYDKPHVSIASFPEVKEKTIVINGFSKAYAMTGWRLGYACAHPIILDAMKKIHQYGIMCSPTTAQFAAIEALKNGDDDVRHMAKEYNRRRRVMVNGFRKMGLDCFEPMGALYVFPCIKSTGMTSDEFCEMLLMEEKVLAVPGNAFGECGEGFIRCCYASSMENIVEALKRIERFIKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHF5</accession>
    <name>A0A174BHF5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_4</name>
        <name evidence="6" type="ORF">ERS852471_00792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264140.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00177">
        <property type="protein sequence ID" value="CUO00177"/>
        <property type="gene ID" value="ERS852471_00792"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO00177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="434" mass="47560" checksum="82CFF1B4E5734BA6" modified="2016-09-07" version="1">MTKEFLKYAIPSALAMFTSALYTVIDGIFVGQGVGSLALAAVNIVLPFTVMLFGIANMFAIGGGSLVSKNIGAKKIDKAVNIFRQVFKFLFIISIGISLFCIIFTNQIVTVLGATENLKPMAVEYLRFYALFCIPNLVGIVLNSFVRNDGRPKLAMISTISGAITNVILDYVFIFPLGMGIKGAAIATGLGQIVTVAILLPHFLMKKGYLSFGNVKIEKEKIKEFCTIGFPSFFAQASYSVIVLLHNIAIVKLVGEIGISAYSIMNYLTTNVYMVLYGITLGVQPLISYNYGRKKSEKMLGFYKITCKSIILVTTVFTVIIYLFGLNLINIFTNDNSLANIAFNAIKINIFSYFAVGLNLNTLVYYQAIEKPKYSNIVCILRSVAYLPISIFVLSKLFGINGIWAAAIVAETATYITMRLKTNIEESTAEMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHQ4</accession>
    <name>A0A174BHQ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99719">
        <property type="protein sequence ID" value="CUN99719"/>
        <property type="gene ID" value="ERS852471_00783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021062">
        <property type="entry name" value="ArAE_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038323">
        <property type="entry name" value="ArAE_1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11728">
        <property type="entry name" value="ArAE_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ArAE_1_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN99719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="321" mass="36902" checksum="E186A8BFF462754C" modified="2016-09-07" version="1">MKYIYNLAFKMALSATIALVIGEALGFKYSTVAAVIAILGIQDTRRKALIVGRNRAIACIIGQILSLIIYGILGNGAISFGIFLLILIPITSRFNIQEGMIASVVLSTHLLVADKIDLNLIINEFGIMIIGIGVSSIANLFMPALEDEFRKDKIWIEEKYKVILLKMSKSLLTQTVDIDEQKIMDDIEKKLISSNITAYKIVNNNFFKSSSYYTDYIAMRRNQFDTIKKMRKNFERFSMPVDQMKNMSIFLKRVAEDIRENNDCKELLYGLEKLKLQYKEMELPKTREEFENRAQLLNLLNDMEDFLNIKRNFVLNNKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BST3</accession>
    <name>A0A174BST3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pldB</name>
        <name evidence="2" type="ORF">ERS852471_00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264236.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02725">
        <property type="protein sequence ID" value="CUO02725"/>
        <property type="gene ID" value="ERS852471_00840"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="54"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="329" mass="38650" checksum="21F663853355A6CD" modified="2016-09-07" version="1">MINNLERGYFYNFGRDLENINRVEERLNRIKKMGYFKGENDLDIYYETYIVEREKGRIVISHGFCECLEKYKEIIYYFIEEGYSVFGIEHRGHGRSGHLSKKYKSQVNVEKFDYYIEDLKRFLDQIVKEKGKDLYLYAHSMGGAIGTLFLETYPGYFKKAVLNAPMMQINTGKYSNFIAELLAKFYIAIGKGDNYIFGHKDFDGIDDLEGSGTSDKYRYMHHLSYLKENKECQRGGGSFRWVNEGLKATRKLLKEENIKKIDIPILLFQAGNDTFVVNEAHNEFKAIAKDCAIVYINEGKHELYFERDSILHSYLDRIFNFYEQGNVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIR2</accession>
    <name>A0A174CIR2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite ATP-independent periplasmic transporter solute receptor, DctP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dctP</name>
        <name evidence="3" type="ORF">ERS852471_00985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264520.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11595">
        <property type="protein sequence ID" value="CUO11595"/>
        <property type="gene ID" value="ERS852471_00985"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019210" evidence="2">
        <location>
            <begin position="27"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="342" mass="38368" checksum="F5FE4A1CEA9E08DD" modified="2016-09-07" version="1">MKKWGSIGRRVVLSSISVLMMLNLAACGNKNINDEDYKLTLRLSHVFSPDEQLTKTMDLIAERIYEKTDGAIEILTFPQGQLATYKDGLEYVVRGAHFISVEDPSYLGDYVPDFKALVGPMLYTSFEEYSEMIQTELVQDMIKKAEEKGIKILGLDYIFGFRNLMTNKVIETPADLKGVKLRTPGSKLFIDSINAMGATATSLTFGETISAVQQGVVDGLEGSEFSNIGTKCYEVVKNVALTKHFLGTCGAYINLDLFNSIPEKYRNIIEEEFAYGAQEMIEIMNESYEQTVADLESFGVQFNEVDTEAFSEVTKVVYENMDGVTPGIYDMLQEELKKMRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CMC0</accession>
    <name>A0A174CMC0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Chorismate synthase</fullName>
            <shortName evidence="10">CS</shortName>
            <ecNumber evidence="4 10">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">aroC</name>
        <name evidence="11" type="ORF">ERS852471_01012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="10">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 10"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264543.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13070">
        <property type="protein sequence ID" value="CUO13070"/>
        <property type="gene ID" value="ERS852471_01012"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="357" mass="38802" checksum="AE775D3AD3690594" modified="2016-09-07" version="1">MSGMWGSKIKISIFGESHGNAIGINIDGLPSGLELNLEDIAYEMRRRAPGKSPLSTARSEEDIPEILSGYFNGKTTGTPLCAIIRNTNTRSKDYSLLKDVMRPGHADYSGNIRYNGFNDYRGGGHFSGRITAPLVFAGAICKQILKEKGIVVAAHVKSIKDIKDKSFLDSDIDLNFVEALKTFELPLIDKSIKENMRKEILEAKEDMDSVGGTIECGVFGINPGVGDPFFDSVESTLAHLLFSVPAVKGVEFGRGFELTNMRGSEANDEIYYDNGEIKTRTNNNGGILGGITNGMPIIFTTAIKPTSSIGKEQKTVNINTKENTILKVEGRHDPCIVQRAIPVIEAVTAIGILELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVV3</accession>
    <name>A0A174CVV3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15855">
        <property type="protein sequence ID" value="CUO15855"/>
        <property type="gene ID" value="ERS852471_01041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043720">
        <property type="entry name" value="DUF5661"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18905">
        <property type="entry name" value="DUF5661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="117" mass="13579" checksum="E43C485153B6F356" modified="2016-09-07" version="1">MSKTKSEVKKIRKKISYTLKHERESKNQPSFTKEDALLIARALKIDFAKEKFDLDEFTAGVNVELEHGTKCPECNVTKNDPILTGKIALAHLKEFPDYYTRLKKLEEEATKYWSENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D686</accession>
    <name>A0A174D686_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">clpP_2</name>
        <name evidence="5" type="synonym">clpP</name>
        <name evidence="9" type="ORF">ERS852471_01145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264663.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21054">
        <property type="protein sequence ID" value="CUO21054"/>
        <property type="gene ID" value="ERS852471_01145"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO21054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="201" mass="22494" checksum="C0C14BB638FA6174" modified="2016-09-07" version="1">MRIYGCDSEKDEKNEKTKETPNVVMEKLLKSRTIIISGEINQALAERVIAQLLILEEMGDEPIKIFINSQGGHVEAGDTIHDMIKFVKPKVIIIGTGWVASAGITIYLAADKENRYSLPNTRYMIHQPLGGFNGQATDIGIEAEEILRMRKRINTIISEATGQSLEKVERDTDRNYWLSANDAINYGIVNKIITESSELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBR7</accession>
    <name>A0A174DBR7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cxxc_20_cxxc protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264702.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23152">
        <property type="protein sequence ID" value="CUO23152"/>
        <property type="gene ID" value="ERS852471_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026369">
        <property type="entry name" value="CxxC_20_CxxC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04104">
        <property type="entry name" value="cxxc_20_cxxc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="106" mass="12753" checksum="29B4548B50125F1F" modified="2016-09-07" version="1">MLKKICPHCNYKFSTKDIFIRKHSQYITCPQCQNKLIASIKSKFIFSVIMLLTFIFWAIITDSAYINIESWIKYLLAFILFFILFFIIEPLTYKFEIFEDLSKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKZ6</accession>
    <name>A0A174DKZ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO25009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264723.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25009">
        <property type="protein sequence ID" value="CUO25009"/>
        <property type="gene ID" value="ERS852471_01204"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1462577at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="365" mass="43082" checksum="7C2A4B5FDE38F9DD" modified="2016-09-07" version="1">MKKKLLIINGYEQFGYHTDTYNYCLYLYKDFSITFISPYLGLEKIVNEDINIKYIPQIKNRALRFIFKIIYIIFYTIVINPDIIFLKYFTGCSIIKKLFFNKKFVLDIRTSQVVGTLKEIRSYNNKILKESEVFENITIITDEVRELLKIPEDKCNILPLGGKTLIKLEDDLNLDLDKKISLIYVGTFTRRRIIDTVKAFNKLSEKYNGENLEYKLIGFFENDIDEKMLLEEIKKNQFNNIKYLGRVKNEELGKYFLESNIGVAFIPITEYFTNQPATKTYEYLFNGLFVIATSTIENQKVVNNKNGILIDDTEEAFYDALEYLYNNKVSFSRREIINTINNNSWENISLELGKYFNNILENNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM46</accession>
    <name>A0A174DM46_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0291 protein ERS852471_01229</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0291 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264747.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26287">
        <property type="protein sequence ID" value="CUO26287"/>
        <property type="gene ID" value="ERS852471_01229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01103">
        <property type="entry name" value="UPF0291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009242">
        <property type="entry name" value="DUF896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37300">
        <property type="entry name" value="PTHR37300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05979">
        <property type="entry name" value="DUF896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="63" mass="7654" checksum="519C4198C7ECF68F" modified="2016-09-07" version="1">MDYTKAPIDDVIKRINELYKKSKEEGLNEEEKEEQQKLRRRYIDNVKANFRVQLEGVELKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DP21</accession>
    <name>A0A174DP21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27341">
        <property type="protein sequence ID" value="CUO27341"/>
        <property type="gene ID" value="ERS852471_01249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="306" mass="34817" checksum="4C20118E10F88E69" modified="2016-09-07" version="1">MDNIGGIIVAAGNTSYKVSPLLKIGSISIIKRLVLTFQQAGISPIVVITGFQSVEIEQHLVDYGVVFLRNEKFENSDKLYSAKIGLDFLKDKCKKVVFTPVTVPMYNSNTIKNLIEMDKELVIPSYQGRTGHPLLLDCSLIPKILAYDGKEGMRGAIKELITEKDYLEVNDEGILLDVERIERIDELVHLHNEELLHPFIRISIEKEFAFFNSRAKLLLILIEETQSVKGACKYMALSCGKAWSMINEMEEALGYSVVERRHGGRRGGKTVLSQKGKEFLKKYEKYEKDIKEYAVSHFYNIFQESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DRP2</accession>
    <name>A0A174DRP2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_2 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yrrB_3</name>
        <name evidence="3" type="ORF">ERS852471_01268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264819.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28143">
        <property type="protein sequence ID" value="CUO28143"/>
        <property type="gene ID" value="ERS852471_01268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO28143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="570" mass="66305" checksum="2EABD566CC521A9E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWT4</accession>
    <name>A0A174DWT4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
            <ecNumber evidence="4">2.6.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lysN_2</name>
        <name evidence="4" type="ORF">ERS852471_01279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264839.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28678">
        <property type="protein sequence ID" value="CUO28678"/>
        <property type="gene ID" value="ERS852471_01279"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO28678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="55169" checksum="A58F8E8315914C63" modified="2016-09-07" version="1">MEEYILELNEEEPKYIQIANHIKKLINSKIINDGEKLPPIRKLAEFLKVNNVTIINCYKKLQSEGYAYQKMGSGTFAKRRELVQSFKNEYSKEIKNIINKNYEDIIDFTGESLIDVYFPINEFKDVLNKVLDRDGAEALLIQETLGYSELRETINKVFWNKEFDEEEILILSGAQQGIDIAAKAIVNINDNVMVEKPTYGGALSVFKWRRANIFEVPINDDGIDIKLFEEILKKNKIKCFYAMSYLHNPTGISYSKECKLKILELAEKYDFYIIEDDYLSELIYDEELTHEPFKILDRGNRVFYIKSFSKIFLPGIRLGYMIYPNGFKEVMQSSKVNTDTATSTLMQRALELYIKEGYFTGHIESLKKEYKKRYNIMKKLIKDELSNYVEMKEPRGGLYFYLKLKDKNISSKELFYILKDKKIFITPGVIFYKEIDGGIDSFRLCFSQTNEEKIREGIYTIKEVIDKWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E051</accession>
    <name>A0A174E051_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264937.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31133">
        <property type="protein sequence ID" value="CUO31133"/>
        <property type="gene ID" value="ERS852471_01335"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2080728at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020342" evidence="1">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="126" mass="14034" checksum="B2091206175D09F6" modified="2016-09-07" version="1">MKLKRVLVITLVLILSLSFSTFASNKEKSPIFMGKVSEVIKDEKENSVRVKAKGYIKGCSVYEEELILIVTEETEILGNECGNQEKVEKEVCVGDLIFAKLDKAMTKSIPPQVVAKKIQISKVNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E1P2</accession>
    <name>A0A174E1P2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264965.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31701">
        <property type="protein sequence ID" value="CUO31701"/>
        <property type="gene ID" value="ERS852471_01350"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019365">
        <property type="term" value="P:pyridine nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044717">
        <property type="entry name" value="NIC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47297">
        <property type="entry name" value="PTHR47297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="209" mass="23451" checksum="290BB204759252DE" modified="2016-09-07" version="1">MKEIIEELNLLPIELKSLPLENTALIVVDMVVGFVEEGILSSPRVKNMSTNLLELNNRTKGYSKVYFVDSHNEDAEELKAYPSHCIVNTKEEELIDGLKESVSEDETIRIIKKNSTNGFHAPEFKSWLDGIIDKVDNFIVVGCVTDICVLQFTLTLKTYFNQMNLGKRVLVPANCVETFDIPGHPGDEMNLFALSNMKSNGIEVVSEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGU5</accession>
    <name>A0A174EGU5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pur operon repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purR</name>
        <name evidence="7" type="ORF">ERS852471_01411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265071.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35435">
        <property type="protein sequence ID" value="CUO35435"/>
        <property type="gene ID" value="ERS852471_01411"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1231912at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045982">
        <property type="term" value="P:negative regulation of purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015265">
        <property type="entry name" value="PuR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010078">
        <property type="entry name" value="PurR_Bsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864:SF2">
        <property type="entry name" value="PTHR43864:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09182">
        <property type="entry name" value="PuR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01743">
        <property type="entry name" value="purR_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="PuR_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="111"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="271" mass="29891" checksum="456B272BF58A7BE2" modified="2016-09-07" version="1">MEKLSRNNRVVAITKILTETPNKVVGLNKFSELLNAAKSTISEDIVIVRELLEKLEMGKIETISGAAGGIKFIPDMGSASKLEFCNELCDLLTEEGRIVPGNFVYLTDIMYNPQIISKAGVILASYFKDMNIDYIVTVETKGIPLAYEVAKCLGIELVIIRRDNKITEGPTVTINYVSGTSGRIQQMSLAKKSMKPSSKCVFIDDFLRGGGTAQGIKDLLKEFDSELVGTGVLVDNIGIKNKRASEYIALIELEFDENTEELHVKPSEFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQN1</accession>
    <name>A0A174EQN1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4325 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265182.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38270">
        <property type="protein sequence ID" value="CUO38270"/>
        <property type="gene ID" value="ERS852471_01474"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1876090at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025474">
        <property type="entry name" value="DUF4325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14213">
        <property type="entry name" value="DUF4325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4325" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10336" checksum="908226A2464C6BD0" modified="2016-09-07" version="1">MRKDIKVKNLLGNSYSCEDAIVLKDSIRKNIESGVVLDFEGYDRISTSFLTCLFSELIEKLGREYVFKHISVKNLTNYSDYSRVVLGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6Y5</accession>
    <name>A0A174F6Y5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid A core-O-antigen ligase and related enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265360.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43905">
        <property type="protein sequence ID" value="CUO43905"/>
        <property type="gene ID" value="ERS852471_01564"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915721at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="439" mass="50168" checksum="D3E032F8130D0831" modified="2016-09-07" version="1">MKSKEKLLAIIISILLFLMMFAPANLMRVKIAITIVLFFISLYYVFLKRYEIKINKKVFWWFVIYIGMSIVSMSISFINGNPGATNFLVVNIIGPCIFFAFIMSVSNSIYYNLINKIIIYTTIIIGVYNLVYFFIINDIFPFINPEIFPFIKANVGGINLGFTKITTENLSYLMFLFPYVFTLFFIEENKKIKNIALTASLLSILSAIISARTIFLLIIGISPILVILYGYLGNIPNCKIIAKRVLAICIIGTLLLAILLSIMKIDISKIADKIVSSFRVEQVADENGNIDPGAKIRVEQLEDLIYTWKQKPILGWGDGANALNVIRSDVEGMYELSYFALLMQRGIIGLIIYASQFFWIIIIAIRIIKIDKKNRNDMYCSLVGLTCMLIANATNPYLYSFDRLFIIFYPLLIINKSYLFLESEDELYSIKTIYKLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV19</accession>
    <name>A0A174FV19_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA uridine 5-carboxymethylaminomethyl modification protein GidA</fullName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gidA_1</name>
        <name evidence="2" type="ORF">ERS852471_01757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO54063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265715.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54063">
        <property type="protein sequence ID" value="CUO54063"/>
        <property type="gene ID" value="ERS852471_01757"/>
    </dbReference>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="311" mass="34412" checksum="4F0B94F3869D94F3" modified="2016-09-07" version="1">MKEYNLVIIGAGASGLLAGIAALEENIENVLIIEQEEDLGGNLNLFINNDFGEFHLGEKVPGPEFASILITTYISLNGQFKNNTRVLEITDNKKIKYVNPYEGEAEIIANKIILASGCREKYTGNIIVPIHKYTGIFSTAAAHRLVNFQGLLPGREVILSGNTMWTYILARRLVIEGAKVKGIITSRESVNEDLANIIDEFDVPVICNSEVVEVGGSERIEWARIENYSGKEESKIIECDSLVLAIGYYPEIDYLKNSNIKINEDSLEIENYKTSIDDIYCCGTIINGRNGLFNSGEDGYKVGKIVASQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBB5</accession>
    <name>A0A174GBB5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small basic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265883.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59191">
        <property type="protein sequence ID" value="CUO59191"/>
        <property type="gene ID" value="ERS852471_01845"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930757at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="12505" checksum="BD9BF3BCCE5507D0" modified="2016-09-07" version="1">MIGFIGLLVGVLLGLVLNVNIPDKFSPYMSVAILACLDSVFGALRASLSKSFKPDIFISGFVGNAILAAALAYLGDKLGIPIYIAAVIVFGGRIFDNFAIIRRFLLEKLKNRQRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GD82</accession>
    <name>A0A174GD82_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265936.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60474">
        <property type="protein sequence ID" value="CUO60474"/>
        <property type="gene ID" value="ERS852471_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="113" mass="13257" checksum="35C3E16BC56D8E06" modified="2016-09-07" version="1">MKIIAILLLFIGCIFSIYEMIDSNKLIRYEWFKSLDRSKKINATALLKNFWKKNIILIALMLGMILIVLSTFSKIGNRYENIISIISIIFAVLFIIFSILSRIKYDNKINEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEF3</accession>
    <name>A0A174GEF3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="2 3">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">murF</name>
        <name evidence="6" type="ORF">ERS852471_01850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265893.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59396">
        <property type="protein sequence ID" value="CUO59396"/>
        <property type="gene ID" value="ERS852471_01850"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="5">
        <location>
            <begin position="112"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="4">
        <location>
            <begin position="318"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO59396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="455" mass="50984" checksum="3C3FBFC6C70B6BED" modified="2016-09-07" version="1">MEITFKELLDAIKGEIIIDSSKKEFNKFCIDTRKIEEGNIFVALKGEKFNPNKNAIEAIDKGANIVLVDEVFFDKADIKKEGTIIKVESCHKALLDLANYYRKKLNLKVIGVTGSTGKTSTKDLVAAFLSHKFKVFKTKGNFNSEIGLPLMIFELTSEYDVAVLEMGMSDLGEIHNLAKTALPDMAVITNIGLSHLENLKTQENILKAKMEITDFFDKDSVLVVNGEDRLLNKLDNKCFKIKKTGYNHEYDVYATNIILRENSTEFTAHHKGNEFTFKLPMAGKHNVLNSMLAIDIALNLGLSFEDMNKGLENLEATSMRLQVIKKENITIINDCYNASPDSMKSSLDVLATYNGGRKVAILGDMYELGSKSKEAHAEVGSYATDKVELLIVIGENIEEFRSGYKGKSIVAFKTKDECLDKLKDYINKNDIILVKASRGMKFEEVVNELESISIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH08</accession>
    <name>A0A174GH08_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mutS2</name>
        <name evidence="10" type="ORF">ERS852471_01874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265934.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60428">
        <property type="protein sequence ID" value="CUO60428"/>
        <property type="gene ID" value="ERS852471_01874"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="710"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="530"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="332"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO60428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="785" mass="88371" checksum="DBDD68776870DEED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJ14</accession>
    <name>A0A174GJ14_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">hslO</name>
        <name evidence="7" type="ORF">ERS852471_01889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO61016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265959.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61016">
        <property type="protein sequence ID" value="CUO61016"/>
        <property type="gene ID" value="ERS852471_01889"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1406579at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO61016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="291" mass="31437" checksum="60B4F62B20B4FC80" modified="2016-09-07" version="1">MKDTIITATAKEGMVRIIAGSTTNLVEKAREIHECTPVAAAALGRLLTAGALLGSTLKSEKDVTTLKINGGGDAEGVVVTAYKGGIVKGYIGNPYGDLPLNSKNKLDVGGYIGKNGNLIVIKDLGLKDPYVGQVPIFSGEIAEDLAYYFTVSEQTPSAVALGVLVNTDYSIKCAGGFIVQMMPGADDLLADVITYRLEEIPSITTLLDEGKTIKEIIEYIFDGMDLKILEEVEPEFKCNCSREKVEKALISIGEKELREIAEEGKDEELKCHFCNASYVFTKEDIQKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTA3</accession>
    <name>A0A174GTA3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">artP</name>
        <name evidence="7" type="ORF">ERS852471_01935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO63705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266042.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63705">
        <property type="protein sequence ID" value="CUO63705"/>
        <property type="gene ID" value="ERS852471_01935"/>
    </dbReference>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022820" evidence="4">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="45"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="45"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO63705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="274" mass="29506" checksum="5A9C1E3A5C51344C" modified="2016-09-07" version="1">MKKSLIKKIMAVVIVGVIGIMAVGCSSKSTGEVKDKLTEIKESGKLVVGMSADYAPYEYHALIDGEDKIIGFDVDIAQAIADDIGVELELKEMNFDSLCEAVQLGKIDMTISGMTPKPDRKKAVDFSDIYYKAEQAFLIQASNKDTYKTLADLEGKKIGAQMGSIQAEIAEGIEGASVKLLSDVNTLILELKNGNIDALIIEAPVANLATTTNTDLVVGEEIIEDSEGGSAIGMPKDSPELVEQVNSTLKKLMDEGKIDEFVQKAVEQVKNQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUT7</accession>
    <name>A0A174GUT7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monosaccharide-transporting ATPase</fullName>
            <ecNumber evidence="8">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rbsC</name>
        <name evidence="8" type="ORF">ERS852471_02000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="8"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266161.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66283">
        <property type="protein sequence ID" value="CUO66283"/>
        <property type="gene ID" value="ERS852471_02000"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO66283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="350" mass="37595" checksum="C923CC679DD595E5" modified="2016-09-07" version="1">MDNKNGLIEKIKGQGLQKLFSLIALVVLILVFSLLGQNFFSKESFVNILDSSYYIGFMAIGVTFVIITGGMDLSIGTVMMCSALLGGVAYNVWGWSIGMALALIVVVATLFGLVNGILIAKLKLPPFIATMGTMLISQGLGSIIAKVQTQRYPTAYEEAGWFKSVFFKTEGGFPMGIIFLAIFFIVAFIILNKTRIGRYAFAIGSNEEAVRLSGVNVDKWKIMVYVISGFFAGLGGIMYAATYTTIIPGTGNGIELQAIAAVVIGGTSLAGGIGSITGTIIGVYVMSVLKNGLMSMNLQGQWQVFFTGVVVICAVLIDIYRNKKANEVKKDKKESKKVREVKSTSGALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYG8</accession>
    <name>A0A174GYG8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65849">
        <property type="protein sequence ID" value="CUO65849"/>
        <property type="gene ID" value="ERS852471_01989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6081" checksum="D0B1FF5E1E1D8612" modified="2016-09-07" version="1">MAKSNNKQNRTDGTITSAGIKFPTSMSNVNNPTSAYSYTDEKKIEEHAKQNKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYL3</accession>
    <name>A0A174GYL3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide chain release factor 3</fullName>
            <shortName evidence="6">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">prfC</name>
        <name evidence="8" type="ORF">ERS852471_01997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO66156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266155.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66156">
        <property type="protein sequence ID" value="CUO66156"/>
        <property type="gene ID" value="ERS852471_01997"/>
    </dbReference>
    <dbReference type="OrthoDB" id="164090at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO66156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="531" mass="60039" checksum="3FE6C2776599B7DA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7P6</accession>
    <name>A0A174H7P6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def_2</name>
        <name evidence="2" type="ORF">ERS852471_02063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266285.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69238">
        <property type="protein sequence ID" value="CUO69238"/>
        <property type="gene ID" value="ERS852471_02063"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="136" mass="15723" checksum="4EFFD563998080AC" modified="2016-09-07" version="1">MIRPIMKDVLFLSQKSEPATKNDIAVVDDLIDTLRVNLEYCVGMAANMIGVKKRILVFSIGNIIVPMINPVILKKEKAYETEESCLSLTGFRKTKRYETIEVEYFDRDFKKHKQIFNGFTAQIIQHEIDHFEGIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HEC2</accession>
    <name>A0A174HEC2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Radical SAM domain protein</fullName>
            <ecNumber evidence="12">1.97.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pflA_1</name>
        <name evidence="12" type="ORF">ERS852471_02114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71696">
        <property type="protein sequence ID" value="CUO71696"/>
        <property type="gene ID" value="ERS852471_02114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023912">
        <property type="entry name" value="YjjW_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00392">
        <property type="entry name" value="YjjI_activase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04041">
        <property type="entry name" value="activase_YjjW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="14"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO71696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="277" mass="30869" checksum="2ADA965C89041AC8" modified="2016-09-07" version="1">MTGLVNKIIPFSSVDGPGNRTAIFLQGCNFNCIYCHNPETINICGNCGTCITACPSGAITKNNGEVFWDKSKCCNCDSCIKTCNNSSSPKISKMSVDDIINEINNYKPFIQGITVSGGECTLQEDFLFHLFTKIKSLGLTCFIDSNGSKDFKEMPKLLEVCDSVMLDVKAFDNTIHNKYISFDNANVLSNLEFLASIGKLYEVRTVIVPELFNNEETVRKVSEIINKYDSNIRYKLIKFRNLGVRQSLKLHPTPSDEYMNTIKSIAEEGGCKNIIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIL3</accession>
    <name>A0A174HIL3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_02152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73256">
        <property type="protein sequence ID" value="CUO73256"/>
        <property type="gene ID" value="ERS852471_02152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="36259" checksum="8D28487BF64DD726" modified="2016-09-07" version="1">MSNKSFLQKVQNMPVAILPTMVGALTLGNVYSGMGYTWVRHITTWAAIIILLVYLTKIIFHFDTFKKEYSNTVPASLYAGATMITMIVGSYFYNASAVFGKTLWFTGLILHAIHILIFTYRNVIKGVNMQTFVPSWFVTYNGIMVSTVVGGVMNEPLIGKIVVFYGIAVLTIIMPFMIYRLVKHEIKDPVFHTQAILLAPSSLCLVSYFNFIKEPNAIIVYYLYALVLAAFIFILWRLPKFFSFDFHPGFAALTFPMAIGIVASNKMSAYLIAQGYEAAGNAVNQLAGIQIYVTTMLIGYILLRFFMLFKDSYKKDKQEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKB7</accession>
    <name>A0A174HKB7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0178 protein ERS852471_02213</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yaiI</name>
        <name evidence="3" type="ORF">ERS852471_02213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0178 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266542.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75334">
        <property type="protein sequence ID" value="CUO75334"/>
        <property type="gene ID" value="ERS852471_02213"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890924at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="147" mass="16600" checksum="E8808C421C606807" modified="2016-09-07" version="1">MRIIVDGDACPGISIIERCAKDYNLELIVYCDIHHYIVLDYGDVKIVDSGFQSVDMKVSNECMENDIVVSQDYGVAAICLGKKAHVINPRGTIYTNENISGMLEQRHISQKIRKAGGRTPNARKRTSEDDERLKKNLLFLIKSNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMP3</accession>
    <name>A0A174HMP3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urocanate reductase</fullName>
            <ecNumber evidence="3">1.3.99.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ifcA_3</name>
        <name evidence="5" type="ORF">ERS852471_02185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>A + dihydrourocanate = AH2 + urocanate</text>
            <dbReference type="Rhea" id="RHEA:36059"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27247"/>
            <dbReference type="ChEBI" id="CHEBI:72991"/>
            <dbReference type="EC" id="1.3.99.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.33" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266510.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74360">
        <property type="protein sequence ID" value="CUO74360"/>
        <property type="gene ID" value="ERS852471_02185"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="1 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022265347" description="Urocanate reductase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO74360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="586" mass="61362" checksum="FDEEE32AEC4395E3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPT0</accession>
    <name>A0A174HPT0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triple tyrosine motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266540.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75297">
        <property type="protein sequence ID" value="CUO75297"/>
        <property type="gene ID" value="ERS852471_02212"/>
    </dbReference>
    <dbReference type="OrthoDB" id="141286at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="414"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="507"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="666" mass="77842" checksum="3AE5FED4AE07C97D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRY6</accession>
    <name>A0A174HRY6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77693">
        <property type="protein sequence ID" value="CUO77693"/>
        <property type="gene ID" value="ERS852471_02281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO77693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="45" mass="5078" checksum="1D82410695BFE5B6" modified="2016-09-07" version="1">MHNYCKTATNNAWASKPTSSLNSCQSCRSHKEEKTATDNKWTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HY19</accession>
    <name>A0A174HY19_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO79804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266741.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO79804">
        <property type="protein sequence ID" value="CUO79804"/>
        <property type="gene ID" value="ERS852471_02328"/>
    </dbReference>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO79804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="28843" checksum="D1F49A4395F0BF2A" modified="2016-09-07" version="1">MIFCSLYSGSSGNSIFVGSEKAKILIDAGLPGKKIDEALKSIGQKAEELDGIFITHEHSDHIKGVGILSRKYDIPIYAPRNTWQAMEKSIGKIKEHNIKVMDKRSVVSINDLDIKSFNIPHDAAAPVGYTVNLGNKQASVATDFGIFTKEIWDNIKDSEVMLLESNHDVSMVEYGPYPYNLKRRILSEIGHLSNEDCGKAIVNILKAGLGKKIILGHLSNTNNHPDLAYQTVVDVLTNSGVNIGSDVILSMANRNNPSEIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I899</accession>
    <name>A0A174I899_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">melR_4</name>
        <name evidence="4" type="ORF">ERS852471_02412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266880.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83343">
        <property type="protein sequence ID" value="CUO83343"/>
        <property type="gene ID" value="ERS852471_02412"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO83343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="307" mass="36868" checksum="EBC81F162645686F" modified="2016-09-07" version="1">MSKVSYEKVNITQDLNAIIEYIDKVNIKEKDFEIKQSYIPPHWHRSIEFSLVCKGEVDLWINNHKNTLKEGDFIFVNSGQVHKLDSPNYEECEVLLVILSYDFLKRVLPDIDNLYFDIKKESPKKKRVYEIYEFFKRFTKKPKLNDELMVNAYIYELLYILINEFQVDLSKDEKKYVISKKRQHKILDYIEENHKEDLNLTLLAEICHMSEEHFSRIFREYFGTNFKTYLTNYRLYSCYHDVVDSAKSMQDIAFDYGFSNVKSFISAFKNSYSMTPYQYRKLYQASKNDNNHNKNNNTTYLNVRTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IAI1</accession>
    <name>A0A174IAI1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_11</name>
        <name evidence="2" type="ORF">ERS852471_02408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266874.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83136">
        <property type="protein sequence ID" value="CUO83136"/>
        <property type="gene ID" value="ERS852471_02408"/>
    </dbReference>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="456" mass="50012" checksum="2B9782187CCE8B09" modified="2016-09-07" version="1">MENKMGTEEIRKLLIKMSLPLMISLLISNLYNLIDSMYVSSLGESALSAVSLSAPIMMMMAAFGSGNAIGLNAVLSKALGEKNNDKVKKAIRTALFLALASYIVIVTSRLIIVEPYFNSQTNDAEIIRQGTEYLNTVMFLAFGVMFQWVLERLLISTGKTKLFMITLSSGAIINIILDPVFIFGLPALGIPALGVRGAAVATVFGQTFSASLALYFNYKFNKDLDMKFSIIPDWHTFIEMLKTGIPTAFMQGFVSVVTMGVNMILISFSTTAVAIYGVVLKVLNMILIMPHGMGLGVIPVVAYNYGAKKRSRVKEAIKFSVIFSIVVGTIGMIILNIIPALILNMFNPTEEMQSIGITAIRILSVTIPLGGISIVLSSFFQGLGLARYSMYLSLARQIILLMPIVFLLSLTEVLPLVWLGFPIAEGLAIIIGYMLYKRSNREVISKIEEELEEKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IBS7</accession>
    <name>A0A174IBS7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cshA_3</name>
        <name evidence="10" type="ORF">ERS852471_02451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266948.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84692">
        <property type="protein sequence ID" value="CUO84692"/>
        <property type="gene ID" value="ERS852471_02451"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="213"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO84692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="368" mass="41695" checksum="90356EEBCCCCD512" modified="2016-09-07" version="1">MNFKDLGISNDIENILKKSGIKTPTPIQQDSIIHILNKKDVIAEAQTGTGKTLAFLLPIFENISLTSNGIQALIISPTRELAIQITEEANKLSLAKDIGVLSMYGGKDIGSQMKKLKGNIRLIIATPGRLLDHLKRKTVNLSTLKTIVLDEADQILLMGFRNEIDTIMKETPKKKQTLCFSATMNASVKKLAYRYMQDPVLVTVKKEEVTLTNIKQEVVETIDREKRETLCKVLDQDNPFMAIIFCRTKRRADELEIVMHRRGYNCKVIHSDIQQSKRERIMKSFKNADIQYLIATDVASRGLDISGASHIYNYDIPESVETYIHRIGRTGRAGNEGYTCLFVDPKDSKMLSQIENEIKLRIPRRTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IDJ9</accession>
    <name>A0A174IDJ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84246">
        <property type="protein sequence ID" value="CUO84246"/>
        <property type="gene ID" value="ERS852471_02438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="50" mass="5467" checksum="B5AE8268BD88D98C" modified="2016-09-07" version="1">MKFDLWRSVEVFVIGLIVCFTTTMLLGDEAFTGIAIIYLAAVIAGKVSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IDQ7</accession>
    <name>A0A174IDQ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+ transporter protein, CorA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_02458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO85382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266964.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO85382">
        <property type="protein sequence ID" value="CUO85382"/>
        <property type="gene ID" value="ERS852471_02458"/>
    </dbReference>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO85382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="315" mass="36250" checksum="14A05D0957867A98" modified="2016-09-07" version="1">MIKIYKSLSETNPHLKALNNIEPGCWINMVAPTEEEIILVSKKTGVPLNFLRAPLDDEETSRIDFEDDYLLVIVDIPFTEMEDNSLTYDTYPLAIIHSEKQIVTVCLKNSRILTDFINNKVKSFFSFKKSRFILQILSRVSTYYLIYLRQIDKKSLMIEKRLHKSMKNRELIQLHSLEKSLVYFSTSLKANEITLEKMLKLEIMQKYPEDQDVLEDVIIENKQAIEMTDIYSNILASTMDFFASVISNNLNIVMKVLASVTILMAIPTIIGGIFGMNVLLPFSPDDPNAFNIIMIFTLLLTGFVAILLYKKDMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IGN7</accession>
    <name>A0A174IGN7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266940.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84528">
        <property type="protein sequence ID" value="CUO84528"/>
        <property type="gene ID" value="ERS852471_02446"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO84528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="98" mass="11449" checksum="35A8B4765A9873A8" modified="2016-09-07" version="1">MRYFIVEGTIINADLMNDNIMKKHMEYSQKAMNEGLILMSGLKEDMSGGLFIMKSESIEKVDNYLCNEPLKVNGIQEYKIVEFSPHYFNQSPNDWFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IH25</accession>
    <name>A0A174IH25_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sagH</name>
        <name evidence="2" type="ORF">ERS852471_02442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266934.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84385">
        <property type="protein sequence ID" value="CUO84385"/>
        <property type="gene ID" value="ERS852471_02442"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="381" mass="43018" checksum="4D3E592EECE41B34" modified="2016-09-07" version="1">MISIIKGIILNQIRKKNSTLFKIVFPVFLILVLGFTLSNDFETGRDTSLDKLDVLYIDNGDDYSKEVLKAFKKIDSGLEIEFKEATSIEEAKQRVRIEKAVFLYLNKGIIEIYSNDKYITNSSIVYGMLKGISNGLNATLEMYNVNPQRDFTITPIEKNGILDVETIASTKSPSSMDYYGVAEIGLMIFYYFSMPIYYMKEERKRNIKDRILLSGISNRKYYFASFIGYSVFAFSTTTLAYLISKFILGINYGNNILILPIAALPFITLVISLGMFLSIVLKDEDRGEIIGSSVVIPILCFLGGGYIALGDDVNVLFNIVTKISPLRWFNNGLFRYIYNGDSSMLITWVIIGSLATIILLALIYYILGKEDFIDGKCMDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IHE1</accession>
    <name>A0A174IHE1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yycG_4</name>
        <name evidence="8" type="ORF">ERS852471_02454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84798">
        <property type="protein sequence ID" value="CUO84798"/>
        <property type="gene ID" value="ERS852471_02454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="411"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="662" mass="76525" checksum="6C26E13990448476" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IJ26</accession>
    <name>A0A174IJ26_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplX</name>
        <name evidence="8" type="ORF">ERS852471_02504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267043.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87274">
        <property type="protein sequence ID" value="CUO87274"/>
        <property type="gene ID" value="ERS852471_02504"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO87274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="104" mass="11391" checksum="516260E0DF0D460E" modified="2016-09-07" version="1">MKLHVRKNDTVVVISGKDAGKTGEVLKVYPKTGKVLVQGVNIVKKHQKPTRANAQGGIIEKEGAIFSSKVMLYCTKCKNATRISNKILEDGTKVRTCKKCGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ISG5</accession>
    <name>A0A174ISG5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rpsM</name>
        <name evidence="11" type="ORF">ERS852471_02518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267060.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87875">
        <property type="protein sequence ID" value="CUO87875"/>
        <property type="gene ID" value="ERS852471_02518"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO87875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="121" mass="13697" checksum="A32C1255CB28E251" modified="2016-09-07" version="1">MARIAGVDLPREKRVEIGLTYIYGIGLSTSQKILATTGINPDTRVKDLTEDEVNEIRNYIKDLLVEGDLRRDVALNIKRLVEIGCYRGIRHRKGLPVRGQKTKTNARTRKGPKKTIANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ISU6</accession>
    <name>A0A174ISU6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fecD</name>
        <name evidence="8" type="ORF">ERS852471_02569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267153.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90492">
        <property type="protein sequence ID" value="CUO90492"/>
        <property type="gene ID" value="ERS852471_02569"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO90492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="34672" checksum="E4486021D3B722E1" modified="2016-09-07" version="1">MKNNKKLIILSIVAVALIGLFLTIGVNSANYQYAMYRRIPKVIAMVLTGAAIGFSSLIFQTVTNNRILTPSILGLDSLYVLLQTTVVFLLGSSSVLITNGNINFIITIVVMIAFSAVLYKFVFRKGTKNIFTILLIGVICGTLFESLTNFMQVLIDPTEFLTVQDKMMASFNNVNTDIMLLASIVIILSIAYCYDIVKVLDVMSLGRDEAISLGVDYDKMSKKILVIVVILTSVSTALVGPITFLGLLVVNIARQMINTYKHEVLGLATIIISVIALVGGQLIVEQLLDFGTSVSVIINFIGGIYFIYLVMKERNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IT30</accession>
    <name>A0A174IT30_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplQ</name>
        <name evidence="6" type="ORF">ERS852471_02522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117049.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88070">
        <property type="protein sequence ID" value="CUO88070"/>
        <property type="gene ID" value="ERS852471_02522"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="113" mass="12820" checksum="48D20326D7CAECE8" modified="2016-09-07" version="1">MAGYRKLGLSTDQRRAMLRSLVTSFLKHGKIETTETRAKEARSIAEKMITLAKRGDLHARRQVLSYVLEEEVVKTLFEEIAPKYADRNGGYTRMIKKGPRRGDGAEVVILELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IU73</accession>
    <name>A0A174IU73_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nrdA</name>
        <name evidence="12" type="ORF">ERS852471_02532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 9"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267082.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88495">
        <property type="protein sequence ID" value="CUO88495"/>
        <property type="gene ID" value="ERS852471_02532"/>
    </dbReference>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="10">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="215"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="743" mass="85680" checksum="E07C1F37BF230C6C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IVT9</accession>
    <name>A0A174IVT9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267199.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91504">
        <property type="protein sequence ID" value="CUO91504"/>
        <property type="gene ID" value="ERS852471_02596"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024634" evidence="1">
        <location>
            <begin position="29"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="38"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO91504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="239" mass="27467" checksum="802752B0BF905813" modified="2016-09-07" version="1">MKNSYFYKYLTILFISILLLSIPSSVFCDDEPREAKEKEIYLTFDDGPSGKVTTEVLDILKAEGVPATFFIIGNQIDNQEDLILRMRDEGHSIGLHSYTHERNNLYSSNDGFINEMLKVQKRLYDVTGETYTILRFPFGSTNNTYKLTSSMVDLVHNHGFKIYDWTQDTLDGANPKSSPDSIYSHAISDKDSIILLMHCANVNKTSPQALPQIIKYYKDKGYTFKKITEETPELYRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IW96</accession>
    <name>A0A174IW96_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO89150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205695.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89150">
        <property type="protein sequence ID" value="CUO89150"/>
        <property type="gene ID" value="ERS852471_02548"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1330468at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024728" evidence="2">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="3">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO89150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="138" mass="14510" checksum="0F04383AE981D931" modified="2016-09-07" version="1">MKKKVIAVVLLASMTLTGCGSKAFTGEKVGEVPGGFGGTTKATVKFEEGKPVSVELDNVEDNGSSKAEASEAGTYDMNNAPGKKWHEQVDLLEEAIVSNEFDLSKLNVTDGKTDAVSGVTISVQEFVDAVQNALEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IYH9</accession>
    <name>A0A174IYH9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
            <ecNumber evidence="1">3.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynB</name>
        <name evidence="1" type="ORF">ERS852471_02554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267122.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89920">
        <property type="protein sequence ID" value="CUO89920"/>
        <property type="gene ID" value="ERS852471_02554"/>
    </dbReference>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO89920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="207" mass="23954" checksum="243B380030C3AF95" modified="2016-09-07" version="1">MKFLDLSYEIDNGMPVYPGDEEVNLEKISDLNKDGYESITYSGTMHAGTHIDAPMHMIESDKYICDYPLDNFIGKGVLLDVRGQQEINLKDEYFKLIKENHIVLFYTGFDKKYGQKEYYENHPIITKEMAEFLVRKKVKMVGVDMPSPDRSPYEVHSILLNNNIFILENLTNLEKLIYEENFSVFAQPLKIKAEGSLVRAMAVFQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J3S2</accession>
    <name>A0A174J3S2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal ion ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adcA</name>
        <name evidence="4" type="ORF">ERS852471_02603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267209.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91729">
        <property type="protein sequence ID" value="CUO91729"/>
        <property type="gene ID" value="ERS852471_02603"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008024822" evidence="3">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO91729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="324" mass="36178" checksum="E5FB79B1AADBAD53" modified="2016-09-07" version="1">MKKKYTKILSLLIITLVALMGCSSKNTESINDSNEITIVTSFYPIYISTLNIIKDVPNVKLINMTKAQTGCLHDYQLSPEDLKTLSSADIFVVNGAGMEGFLDKVISNEKDLDIVDSSEGIKLLTADGEEHSHDDENHNHDEEETHADDHDHEDNPHVWVSISNNIKQVQNIANGLAKYDPDNADKYEANAKEYISKLEALKTEMHEVIDTLPNRNIITFHEAFPYFAEEFNLNIVGVVEVEPGTEPSPKQLEETIEIAKNNNVKALFTEPQYAAKAATTISNETGIPLYTLDPIVTGDSTSDAYDDYITKMEQNLETLKEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J837</accession>
    <name>A0A174J837_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Anti-sigma F factor antagonist</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Stage II sporulation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">spoIIAA</name>
        <name evidence="7" type="ORF">ERS852471_02687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO95844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267366.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95844">
        <property type="protein sequence ID" value="CUO95844"/>
        <property type="gene ID" value="ERS852471_02687"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045152">
        <property type="term" value="F:antisigma factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014237">
        <property type="entry name" value="Anti-sigma_F_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02886">
        <property type="entry name" value="spore_II_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO95844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="12724" checksum="C0BC5E1A89BDB9A3" modified="2016-09-07" version="1">MYLNFDKQDNTLIVYLIGELDHHSAEEVRVKIDDRIDRDNIKSLVMNFKDVTFMDSSGIGVVIGRSKKLQGRNGNVCIVEVNNRVDKVFKLSGLYKIINSYENLEEAIKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JGI1</accession>
    <name>A0A174JGI1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB</fullName>
            <ecNumber evidence="11">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mtaB</name>
        <name evidence="11" type="ORF">ERS852471_02722</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO97316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267428.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97316">
        <property type="protein sequence ID" value="CUO97316"/>
        <property type="gene ID" value="ERS852471_02722"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034557">
        <property type="entry name" value="ThrcA_tRNA_MEthiotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00295">
        <property type="entry name" value="threonylcarbamoyladenosine_tRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="138"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO97316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="434" mass="49428" checksum="8C9188ABD0E42EBD" modified="2016-09-07" version="1">MKVAFATLGCRVNQYESEAMAEKFIREGYEVVDFDQFSDVYVINTCTVTNMGDKKSRQIISRARRTNPEAIIAAVGCYSQMSPKEVSEIPGVDVVLGTRNKGDVVYYVNKAKDEGKSQVHVQGVLQNKVFEDLKIEDYQDKTRAFLKIQDGCNRFCTYCTIPYARGSVCSKDPNKVLSEVRELAKNGFKEVILSGIHTASYGLDLEGNVNLISIIEEIEKIDGIERIRIGSIEPAFFTPEVIEKIKSFKKLCSHFHLSLQSGCDATLKRMNRRYTAKEYEDSVNLLRETLPDVSISTDVIVGFPGETEEEFNETYEFLKRIKLTKTHIFKYSPRKGTKAADMPNQIDGKVKDERSKKLIELNDINEKAFTEKFIDREMDVLFEQQVKGKEDVYEGYTRNYIKVEVHCMAANITGRIVDVKLEKAEKDYAIAEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQF2</accession>
    <name>A0A174JQF2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pyk_3</name>
        <name evidence="16" type="ORF">ERS852471_02816</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP01952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267605.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP01952">
        <property type="protein sequence ID" value="CUP01952"/>
        <property type="gene ID" value="ERS852471_02816"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="14">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="15">
        <location>
            <begin position="358"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUP01952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="50256" checksum="A17C9B6F02966D14" modified="2016-09-07" version="1">MRKTKIICTIGPTSEKPEVLSQIIEAGMNVSRHNFSHGDHAEHADRINLVKELAKKHNKQIAVMLDTKGPEIRTGKFEPKKVELKAGDKFTVHAGGDVIGNTQECSVTYAGLANDVKPGDTILIDDGLVGLTVESIDGNQIHCVVQNTGFVATHKGVNVPGVSIKLPALTEKDIADLKFGCEMGVNAVAASFIRKASDVETIRKILNENGGEHILIISKIENQEGVDNIDSIIEVSDGIMVARGDLGVEIPFEKLPAVQKMMIEKCNNAGKIVVTATQMLDSMMRNPRPTRAEVSDVANAILDGTDAIMLSGESANGDWPVESVQTMAKIAVETERQLSYETAVSKAKKHIPAISGVISRAACNAANELQAASIVCSTKSGATARRISQCRPDCAVVAVTETEKVAKSLAFNFGVYPIVAEHKKVMDERIERATELAVENGFAKKGDTIVIAAGMGQVGSTNLLKVSVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K2C5</accession>
    <name>A0A174K2C5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ERS852471_02847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP03419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267659.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03419">
        <property type="protein sequence ID" value="CUP03419"/>
        <property type="gene ID" value="ERS852471_02847"/>
    </dbReference>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="184"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP03419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="762" mass="88387" checksum="C3EF830D36169BF9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K599</accession>
    <name>A0A174K599_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ORF">ERS852471_02870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267702.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04625">
        <property type="protein sequence ID" value="CUP04625"/>
        <property type="gene ID" value="ERS852471_02870"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="38"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP04625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25165" checksum="F63350AB99B85EAC" modified="2016-09-07" version="1">MDKYKEQFIEFMIESNVLRFGEFTTKSGRQTPFFINTGNYTTGEQLSKLGDFYAEAIKKHFNNDVDVLFGPAYKGIPLTVVTAVSMNKLYGANVQYCSNRKEVKDHGEGGILLGAKIDSDKKVVIVEDVMTAGTSIYETAPILKAQGNPQIQGLIISVDRMEKGRGEKSAQEEIKEVFGIQTYSIVTMKEVVEYLYNRELNGKVYIDDKIKVAIEKYYEKYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K874</accession>
    <name>A0A174K874_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05675">
        <property type="protein sequence ID" value="CUP05675"/>
        <property type="gene ID" value="ERS852471_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP05675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="42" mass="5184" checksum="ED8C70A438D29681" modified="2016-09-07" version="1">MSIYILGDFIKVCKALGVEPTWERLHTWRKEMYKFNDYPIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8A4</accession>
    <name>A0A174K8A4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP06008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267770.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06008">
        <property type="protein sequence ID" value="CUP06008"/>
        <property type="gene ID" value="ERS852471_02910"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1869225at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP06008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="409" mass="48344" checksum="5A88DBDD3555C1E3" modified="2016-09-07" version="1">MDFYKYKDNKKIIGSIIKLNRLNQNISQKTLSKGVCVASYLSRIENGDLIPSEEVISIIFNRLGLTFNDSKEFLEKGINRLKLFFESLHFNEFDLTNEIFNELESQENDYITSPLVIDYFLAKLARYCSTPNREKFESSKELLHSSFELLSPQQKFLYNFYVGVDTLNLSDNKSIGKEFIEEALTYKDNGHCYYWLSYAYRIENNPIKSYDCIKKALDFYVTEGNIISIMSCYEKIAEVHFMLDNYSDAITYLKISLSIAEKLKNRYFIEHLNSIISWAYYRLKEYSTSLNYLKNNTGLVDHRMLVPDSITKSLIYFSLNNKTLLKESINELQNAQSLEHINKDLANIIYKLFTIYIDDDNYLKNPMWENLLIYIIDSMHKLLELKKVFITLLKEYYIYNRKYKDALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEG5</accession>
    <name>A0A174KEG5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutT/NUDIX NTP pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nudF_2</name>
        <name evidence="3" type="ORF">ERS852471_02941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267827.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07629">
        <property type="protein sequence ID" value="CUP07629"/>
        <property type="gene ID" value="ERS852471_02941"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="172" mass="19305" checksum="8C93D71BB013A649" modified="2016-09-07" version="1">MKFHEKTIKETHIYTGNYLEINNVEVELPNGKTSNRDIIKHPGACAIIPFLDKETVLLVEQFRKPLEKTILEIPAGKLDKNEDPLNCAYRELEEETGYKAGSITYLGSIATAPGFCDEIIHLYKAENLSLGTKCCDEDEFTSIKTFSLDEVKAMVKSGEIIDTKTISILAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KHV7</accession>
    <name>A0A174KHV7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267941.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10371">
        <property type="protein sequence ID" value="CUP10371"/>
        <property type="gene ID" value="ERS852471_02997"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844907at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019629">
        <property type="entry name" value="Uncharacterised_HI1736/YgjV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10688">
        <property type="entry name" value="Imp-YgjV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP10371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="77" mass="8876" checksum="63C76F4D6164B1C8" modified="2016-09-07" version="1">MFGIPVIEWVGYAASICIAISLLMTDMFKLRIINTIGCILFVIYGFNIKAYPVGVINLFIFFVNIYYIIKMKKDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KI65</accession>
    <name>A0A174KI65_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA_1</name>
        <name evidence="6" type="ORF">ERS852471_03000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267945.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10471">
        <property type="protein sequence ID" value="CUP10471"/>
        <property type="gene ID" value="ERS852471_03000"/>
    </dbReference>
    <dbReference type="OrthoDB" id="466142at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03711">
        <property type="entry name" value="Tet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035650">
        <property type="entry name" value="Tet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="649" mass="74707" checksum="B489D8F3139D8230" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KMS8</accession>
    <name>A0A174KMS8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_10</name>
        <name evidence="6" type="ORF">ERS852471_03034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268013.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12141">
        <property type="protein sequence ID" value="CUP12141"/>
        <property type="gene ID" value="ERS852471_03034"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="313" mass="34708" checksum="C3B1252F018993CA" modified="2016-09-07" version="1">MRNNAKSVYDEFALEVNNLSVAFNMYDKGLNKNDLEVIHELSINVKKGEIVAVVGSSGSGKSLLAHAIMGILPGNSNIKSDIKFYGENLTEKKLKKLRGKDISFIPQSVEFLDPLMKIGKQVIGINGSEKKRKEIFKRYDLEDNVADKYPFQLSGGMARRVLIATAVMNDAKLIIADEPTPGLNIELAMDTLKHFRDIADNGCGILLITHDVDLALNVADRIAVFYSGTIVEIAKVDDFIKGKDALRHPYSKAFIDALPQNKFKSIPGFQPYAGNLPTGCLFGDRCHMRTEECNKNIEMRKLRGGEVRCINAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQ78</accession>
    <name>A0A174KQ78_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB family kinase</fullName>
            <ecNumber evidence="2">2.7.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psuK</name>
        <name evidence="2" type="ORF">ERS852471_03077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.83" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP14374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14374">
        <property type="protein sequence ID" value="CUP14374"/>
        <property type="gene ID" value="ERS852471_03077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050225">
        <property type="term" value="F:pseudouridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP14374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="314" mass="34981" checksum="090BDF73CEBF6A17" modified="2016-09-07" version="1">MIGNDKYILVVGASIVDIIGFGKKEYSPKDSIPGCIKVSLGGVCRNIAENLARVGVNTEFISIVGDDSNGRSILEHSKRIGYRMDNSLVLKDGCTPTYMAILNTEGEMESAIVDMESLNKMDEAFVDSKAEIFENAEYTVVDSDNPMLLEYMLKKYKGKTKFVLDPVSANKAKKIGHLVKYFHTVKPNRFEAEALCGFKIDTDDDLKRAARYFLDQGVENVFISLDADGIYYLTKNEEGRLACGDKVDVKNVTGAGDSFVAGLGYGYMNKFSTIDTLKYAIAMSIVTITHEETINPHMSHEYVEEYINKINWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KSE9</accession>
    <name>A0A174KSE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268065.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13346">
        <property type="protein sequence ID" value="CUP13346"/>
        <property type="gene ID" value="ERS852471_03062"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="219" mass="24949" checksum="661A1182B84EDD2B" modified="2016-09-07" version="1">MIIIKKYILFDLDGTVTDPMIGITKSVQYALNKFDIEVEDLNELCKFIGPPLKDSFMNFYNFTEEDALNAITYYREYFSTKGLYENTVYENFEDMLISLKEKNKSLIIATSKPTVFAEKILEHFNLKKYFDFIAGSNLDNTRTKKADVISYALEQQGITEVSEIIMIGDREHDVIGAKALNIESIGVLHGYGSYDELSNSGANYIVKDVKELHSLLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KVE9</accession>
    <name>A0A174KVE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ERS852471_03071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268083.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13798">
        <property type="protein sequence ID" value="CUP13798"/>
        <property type="gene ID" value="ERS852471_03071"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="324"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="861" mass="100817" checksum="11B9DB78250FE70B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KVW4</accession>
    <name>A0A174KVW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268077.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13615">
        <property type="protein sequence ID" value="CUP13615"/>
        <property type="gene ID" value="ERS852471_03068"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691660at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="598" mass="69997" checksum="DC6DE1590ECB9240" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L047</accession>
    <name>A0A174L047_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="primary">glmU_2</name>
        <name evidence="15" type="synonym">glmU</name>
        <name evidence="17" type="ORF">ERS852471_03144</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268208.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17612">
        <property type="protein sequence ID" value="CUP17612"/>
        <property type="gene ID" value="ERS852471_03144"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="250"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP17612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="456" mass="49694" checksum="9BD3A4C76AD75BAA" modified="2016-09-07" version="1">MYKSALILAAGQGTRIKSDLPKVLHKACGKEMVNHVIDTLRKADITDIKVIIGKGSELVKEKTSSRKVSYSFQEEQLGTGHAVKCAIDFLKGKKGTVAIFCGDAPLITEEIVSRLFDEHNSNNNTATLLTSILDDATGYGRIIREGNEVLKIVEHKDCNEEELKVTEMNAGVYCFDIEKLIESLDKLSNNNSQGEHYLTDVIGILKSQGEKVGAVVIDFEETLGVNSRAQLAQVEAILRKRINAKHMDNGVTLIDPNNTYIGADVVRGKDTIVYPGNVLEGNTVIGERCTLYPNSRINNSTIEDEVEIQSSVILDSKVGSNTTVGPFAYIRPDSVIGNHVRIGDFVEIKKFVIGNNTKVSHLTYVGDAEVGENCNFGCGTVTVNYDGKNKNKTIIGNNSFIGCNTNLISPVTVEDNTYIAAGSTITDDVKSGELAVARAKQRNIPGWVDKRGLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L4K2</accession>
    <name>A0A174L4K2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDGSH-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268174.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16725">
        <property type="protein sequence ID" value="CUP16725"/>
        <property type="gene ID" value="ERS852471_03123"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667004at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="153"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP16725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="351" mass="40956" checksum="1EC86814FFFF53D3" modified="2016-09-07" version="1">MPRVNNVIQQVSQLNTYEQEKVFDFLKTVLMSNGITNSIDEEIAENRFNKGKCCPFCNHYKISKYGKYHGKNGVKQRYKCQNPECKKTFNDFSKSPVSSSKKGLDKWLLYAQCMINGNTIRQCAEIVEINIATAFFWRHKIIDAIRKFIGYGSLEGVIELDETYFALSYKGNHSKSSNFTMPRESRKRGKEINTRGISKEFACVLCGVDRLGNIYTGLICDGRPNYTDINRALSEVVEENSILCTDKHRSYIPFAAQHNFELHQIRGGRKTVDIYNIQRVNAFHSSLKRWIRKFNGVSTKFLTNYLFWYKWTQLFKTEMERNKPKKFFIHANSTHSVSLIKDFKIRRPIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L650</accession>
    <name>A0A174L650_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cap8A_2</name>
        <name evidence="9" type="ORF">ERS852471_03128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268180.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16880">
        <property type="protein sequence ID" value="CUP16880"/>
        <property type="gene ID" value="ERS852471_03128"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP16880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="24909" checksum="08E8101FB3D8F478" modified="2016-09-07" version="1">MGDLKIGKIINILKINFRLILISTLSVTLVSAIVTFFFVSPKYEASSKVYIGKEKFKNVSTTYSNDEVTMYQKLIKTYGEIVKTKNLINKAIKKAGEDITVAEALSKIQAVAIADTQILQIKYTSSSREESYNMIYGLTEEFMKLSKSLYPNGNVHIIEQPKVPEDAVSPNKAMNIAIGAMLGMMLGIGIVFLKEYMNNSFSDKEEIEEFLQVSCLGSIPNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LC06</accession>
    <name>A0A174LC06_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_03219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000032">
        <property type="protein sequence ID" value="CUP21742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21742">
        <property type="protein sequence ID" value="CUP21742"/>
        <property type="gene ID" value="ERS852471_03219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP21742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="206" mass="23073" checksum="CE2E73A2E70C76C9" modified="2016-09-07" version="1">MKYYAVYKGKSGAPKIFTSWDECKKEVIGFKGAIYKSFTSEKEAIDFIALNAGVKSSTSEKKEKDSSIEGLCIYVDGSFMIDKGNYSFGLVAVENGEVIHKDNGKGFDDEAIALRNVSGEVLGAQKAVEFALDKGYKEVTIAYDYQGVESWAIGAWKRNNRITQNYNKFMQEKMKLINIKFKKIKGHSGDKYNDMADMLAKEALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LE13</accession>
    <name>A0A174LE13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATPase/kinase involved in NAD metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP20105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268281.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20105">
        <property type="protein sequence ID" value="CUP20105"/>
        <property type="gene ID" value="ERS852471_03188"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP20105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="22637" checksum="BC873AAF9D0ABBA8" modified="2016-09-07" version="1">MPVRIAILGGPRCGKTTLIQQLYVDLKIRDINVGVATEYSTDYLREKGMIESISEQYGIYLGQLHLEKSLDSFDYAVTDYATFVPYIYGRLMLGDKVRSKKEIEILKDLYSLALRDLPQYDYIFFVPREFGYKKDGVRWQDEEVAQAVDKAILGFLDAENVKYSVIKGSTKERSEQIMKIVGINKEVVQPAAIEEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJQ9</accession>
    <name>A0A174LJQ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24452">
        <property type="protein sequence ID" value="CUP24452"/>
        <property type="gene ID" value="ERS852471_03265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP24452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="177" mass="19045" checksum="C51287D74C0E391A" modified="2016-09-07" version="1">MMKERTKELVWASLFLAIGVIIPYIFHATSLPGQVFLPMHIPVLLCGVILGKKYGVIVGILLPFINSALLGMPPLYPTAISMAFELATYGFITGLLYKDKKCNIFVSLIGAMLVGRIVSGIVNYVLLTVGGSGFVFAAFITSTFVKAVPGIIIQLILIPAILKALEYANKGKVVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M678</accession>
    <name>A0A174M678_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000050">
        <property type="protein sequence ID" value="CUP29269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29269">
        <property type="protein sequence ID" value="CUP29269"/>
        <property type="gene ID" value="ERS852471_03336"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1839196at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP29269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10390" checksum="8234B9C5D4AF2C3D" modified="2016-09-07" version="1">MGKGRRYDQEYKDMIVELFKSGMSLAELSSEYGIAKSTINGWIKDVKEIKVDENEVMTLKEVKALKKEMARIKEENEILKKAMAIFATRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNV7</accession>
    <name>A0A173XNV7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262797.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53404">
        <property type="protein sequence ID" value="CUN53404"/>
        <property type="gene ID" value="ERS852471_00083"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013085at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="160" mass="18876" checksum="A7D6398FA7D94B16" modified="2016-09-07" version="1">MEWLRVQSIAELQELSKVRGKRNLNNIRRIIKADLRNYVIETGIKDKSAQEMISITSNSWDGLYNKICMFRNMIDSYSNSNIDYFKSKEDELIFYILEMDGKRRSEKLGITRKCFLNKEEARKWKNNILKSIHPDKVSHKYSNEAVSEINQLFEEMVGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y145</accession>
    <name>A0A173Y145_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alx</name>
        <name evidence="7" type="ORF">ERS852471_00177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57881">
        <property type="protein sequence ID" value="CUN57881"/>
        <property type="gene ID" value="ERS852471_00177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN57881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="271" mass="31102" checksum="71F9E9AF9F24B9A1" modified="2016-09-07" version="1">MLYTRSALRNFLFWVSLAIAVNIIIYYLYGAGDALEFLGGYVIELSLSVDNLFLFLVIFSSFGIPINYQHRVLAYGIFGAMILRFIFIFLGIAVVNRFHWLLYIFGFILVISSIKLFTNHNETEEFKSNLFMRFIQKIIPVTNKIYGQKFFVRINGHLLATPLMLILILIESSDIIFALDSIPAIFSITTNPLIVYSSNILAILGLRSLYFLLVKLDSMFKCMRYGVGFILMFTGIKLIILYFNIVIPTLISLLIIFIILLFSILFSLIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y229</accession>
    <name>A0A173Y229_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spxA</name>
        <name evidence="2" type="ORF">ERS852471_00172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN57630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57630">
        <property type="protein sequence ID" value="CUN57630"/>
        <property type="gene ID" value="ERS852471_00172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1606021at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="13558" checksum="1D952B294DC4BBF1" modified="2016-09-07" version="1">MTLFISYPKCTTCIKAKKNLQNNNIDFVERHIVEENPTKEELAKWIKQSNLEVKKFFNTSGKLYKEMALKDKLKSMTDEEKIELLATNGMLVKRPILIKDDTVLVGFKEDEYNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YS36</accession>
    <name>A0A173YS36_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmk</name>
        <name evidence="11" type="ORF">ERS852471_00306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66714">
        <property type="protein sequence ID" value="CUN66714"/>
        <property type="gene ID" value="ERS852471_00306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN66714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="23890" checksum="197B9776B4FC1790" modified="2016-09-07" version="1">MTNNKGLLIVVSGPSGAGKGTICKALLEKHDDLFISVSATTRQPRAGEVDGVNYHFITKEDFIKRVEQKDFLEYAEVYGNYYGTPKSKVEEMLNSGKNVILEIDIQGALKVKENFKEGVFIFILPPSMEELKQRIIKRGSETPESLMRRFKSAYQEINYISKYNYAVVNDIVDVAVSKIEGIITAEKCRVDRIKDTILDSKEGLIHEQLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z3V6</accession>
    <name>A0A173Z3V6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, 2-nitropropane dioxygenase</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263344.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70379">
        <property type="protein sequence ID" value="CUN70379"/>
        <property type="gene ID" value="ERS852471_00370"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="11"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="355" mass="38472" checksum="1B2558AD71A125E6" modified="2016-09-07" version="1">MKIKPLIIGDLITKLPIIQGGMGVGVSLSNLAGNVAKHGAIGVISAAHAGYMEDDFEENTTEANIRGLKKHIRRAKEISFNGIIGVNIMVATNYYKEHIKAAIEGGADLIISGAGLPLKLPEFIGESLIKIVPIVSSAKATNVILKYWYKHYNKTADAIIVEGPLAGGHLGFKKDNLEDEIKNFDKSIKEVIQEISNFEKIFNKKIPVIVAGGIFDSDDFKKYLSLGASGAQVATRFVATHECDAHINFKNAYINSTKNDIELVKSPVGMPGRALRNKFTETLKKENIPVKKCYNCLIPCNPATTPYCISEALITAVKGDTDNGLIFCGSNAHRINAITSVSDVLSDLTKDLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8P2</accession>
    <name>A0A173Z8P2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhhT_1</name>
        <name evidence="7" type="ORF">ERS852471_00398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN71856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71856">
        <property type="protein sequence ID" value="CUN71856"/>
        <property type="gene ID" value="ERS852471_00398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN71856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="380" mass="42379" checksum="3DA3896D6C909BC5" modified="2016-09-07" version="1">MKNFIGEKFKEYWGLVTYTIILAYVIFNFKNIISGGKNIIGIISPFIIGIAIAFILNLVMRIFEERVFKFLDSRKYIKYSSLKRPLSVALTFITVVAVICGLIIFIIPQLIDSVSTLTDTVPGYIKSFEALIDKYVSNTEILSTLWNNFLSAWKEVLQFTGQIVVSSLSGVVNITVGFTSGLVNFILSLIFSIYMLLNKERLQLGMKKVLYAFSKKNFADKVMYLGRVANESFSSYIGGQFIEAIIIGVLCFIGMIILNMPYALLISVLVAVTALIPIFGAFIGTIPSAFIILIIDPMKALWFVIFIIVLQQIEGNLIYPRVVGSSVGLPPIWVMLAMLIGGNTFGLLGMLLGIPTFSVIYKVSKEFINKRLNNKNIIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZA12</accession>
    <name>A0A173ZA12_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN72767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263427.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72767">
        <property type="protein sequence ID" value="CUN72767"/>
        <property type="gene ID" value="ERS852471_00418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN72767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="121" mass="14561" checksum="8D7622A849E03E20" modified="2016-09-07" version="1">MIINKLLLSRKEVNTFLEVIGDSMINHEFVKYFLDIDKDRLIKYNLFFNKIEDAFENEDISTIEIELSLDVNKELKYIVYNYIKRNIAKIYKEEISEIMDIIESLDSVRVTEIDDMMTYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZF88</accession>
    <name>A0A173ZF88_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263464.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73878">
        <property type="protein sequence ID" value="CUN73878"/>
        <property type="gene ID" value="ERS852471_00439"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2072168at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016835" evidence="1">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="122" mass="14226" checksum="D935AF7D129260CC" modified="2016-09-07" version="1">MKKIISVFALFTIVFALVSCTKEKPSEYTPNKAQLITVENAENIYNQLPEEIKKEIDFDYENINIDKVVLKEEMGNILDKTYINKEVLRLNFIIRNKNIQPNNRIAFATIEDFKYIGDGYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFC2</accession>
    <name>A0A173ZFC2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FliB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fliU_1</name>
        <name evidence="1" type="ORF">ERS852471_00459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74941">
        <property type="protein sequence ID" value="CUN74941"/>
        <property type="gene ID" value="ERS852471_00459"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1674644at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="386" mass="45415" checksum="E79B47BCF1240F96" modified="2016-09-07" version="1">MKIRVPDYFNDFKCIASECEDTCCAGWGIVIDEESYNHYMSVEGEFGERLISEIVTEGSENIFVLKGDNCPFLTENKMCDIYTNLGEDSLCYTCRQYPRVMEEFGSLREVCLSLSCPEACRIILRSDKKVTFTLTENDEEVTGYNDINAMLYINLMQSRNIVFKILQNRDIDLNKRISIALKFTSEIQEKIDLNNIQGIKEVIEKYSDNKFVESIVNDLELYKGKESLKYNNINEIFKVFKDLKHINPNDPLGLENALRYFWQSEEDEDIYLRKHREFNKYFNDKIFKFENILVYFVFRYFMKAVFDYDVSAKIKTAIVSYIMIKELYLIRWIEEGGKLSEEDLVDIAHTYSKDIEHLEENIETLAEVFETNNVFDVNNIIVTLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZIG1</accession>
    <name>A0A173ZIG1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccpA_1</name>
        <name evidence="6" type="ORF">ERS852471_00468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN75419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263517.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75419">
        <property type="protein sequence ID" value="CUN75419"/>
        <property type="gene ID" value="ERS852471_00468"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN75419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="38427" checksum="7F067E48C7EF8BD3" modified="2016-09-07" version="1">MVKQEDIARILNVSRTTVARALNGKGNIKPETKKRILDLCEELGYVKNPISTSLALKNEKNIYAFIIKGRNNYYTETIKRGLRAAYKDMSMYKLNLFIVETHIDFPEEQVERVKKVIRQKQVDGIIITPLLKEKIKKIKIDNPDISFIALDLPLDRGTISIYSNYNKLGRILGNLLLNSLEKGDKVLLIETDDDMISAKDSFEGVYQKLLEERKNDIIGPIFISDLENNIPEVINKYLTKDIKAVYASRFLESMIEYIFEKEEYELKIVTIGLSDKIKKFIKEGKVKASLTPDYFEMSHTAINMMFECIYRGVKPEKIKNEHEFKIIVKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZST7</accession>
    <name>A0A173ZST7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylose repressor XylR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylR2</name>
        <name evidence="4" type="ORF">ERS852471_00498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79341">
        <property type="protein sequence ID" value="CUN79341"/>
        <property type="gene ID" value="ERS852471_00498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN79341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="395" mass="42813" checksum="5CB0CFEC890C2E59" modified="2016-09-07" version="1">MKKLNVEAILKVIKNNGSLSRADIAKLTGLTPASVTNITKILIESDYLIERGIGESNGGRPPIILEINIKARYIIGVSIGVGSIDVVLTDLGAEILAKKSIYIDENNTNKEFVFTHLINLINEVIEISEVNRDKVVGIGVAMHGVVNPMLGISQYAPYYKWENVNIKLILEEKFKCPVFVDNDVRAIALGESLFGAAKSIDNFVEINISNGIGAGIIIDNKPYYGVDYSAGEIGHMVVEQDGSLCKCGNYGCLESVASNISVERKVIRSIKQGVKSSLVDDVKDIEKINIKDISIAASKGDELAISVLKEAARYIGVGISGLVNILNPKLIVVVGDIFEQEKIMIETLSEVVKKRGLKIPSENVKIVKSDLGENAAVIGAATLVIQEVFKGREFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVY5</accession>
    <name>A0A173ZVY5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECF subfamily RNA polymerase sigma-24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sigM</name>
        <name evidence="3" type="ORF">ERS852471_00505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263603.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79760">
        <property type="protein sequence ID" value="CUN79760"/>
        <property type="gene ID" value="ERS852471_00505"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="159" mass="19011" checksum="6A5024A984419D21" modified="2016-09-07" version="1">MKQMEELYLNYAKTVHKYLICLTNDVNIAEDLTQETFYQASKTIKNFKGECKVSVWLCQIAKYSWYKRLEKNKKYNCDSYEDISFEIVGYQNLELDLLKNEDKMELFKKIHLLDSQSKEIIFLRISGELSFREIGDIFNKSENWARVSFYRAKPKLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZWG0</accession>
    <name>A0A173ZWG0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">melR_1</name>
        <name evidence="3" type="ORF">ERS852471_00502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN79565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263597.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79565">
        <property type="protein sequence ID" value="CUN79565"/>
        <property type="gene ID" value="ERS852471_00502"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="122"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="26076" checksum="A2A9951A027D3138" modified="2016-09-07" version="1">MYESFISDISIFSNDFDSFIDTRNRPAILYNISQKHIGELRDAVPCDLKRDDLLIWNAVFAREIIRRGVAKKYLHPVYNKYYEKIIKTSELSKLQDIELDMANTYLELLISDVEVKDNFIVNKILQYLHMNIESHVSLEDIATHLNITPQYAVSCFKKHMGISLMKYSKKIRVDRAKVLLMTTTKSILDISLVLGFYDQSHFTKTFKSFEGVSPSEFRNTHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIJ7</accession>
    <name>A0A174AIJ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN87719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263793.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87719">
        <property type="protein sequence ID" value="CUN87719"/>
        <property type="gene ID" value="ERS852471_00609"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="194" mass="21084" checksum="0AD6B44090865020" modified="2016-09-07" version="1">MSKNNWIKGALILGFSFFIAIFLVKPIGVSTQFSVLSGIIHSSIDKNVIVEDPLRESGYSSANAYYDKNDGKLAKAIKHPLNYDFIFVLAIPVGGYIGYELLKRRKKSEALDTSSNLKVCELGDDTSFIKNYAPSFIGGFLLLYGARMADGCTSGHMMSGMMQGSVSGYVFAASVFATAIPSSLIVKHLKNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANP3</accession>
    <name>A0A174ANP3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-0 gamma-glutamyl ligase</fullName>
            <ecNumber evidence="2">6.3.2.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263838.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89108">
        <property type="protein sequence ID" value="CUN89108"/>
        <property type="gene ID" value="ERS852471_00632"/>
    </dbReference>
    <dbReference type="OrthoDB" id="753699at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="43949" checksum="75A25F3AEE522BB1" modified="2016-09-07" version="1">MERIIGTVVRGLRCPIVKEGDNIEQIVVDSVLKAVETENLTLNDKDIVTVTESIVARAQGNYATIDQIGQDVSSKFGEDTIGVIFPILSRNRFAICLRGIAKGAAKKIVLMLSYPSDEVGNHLVDLDLLDEKGINPWTDVLTEAEFRNLFGYNKHTFTGVDYIEYYKSLIEEYGIECEVIFSNDCRTILNYTKSVLTCDIHSRFRTKRLLRANGAEKVYGLDDIMTESIDGSGCNKTYGLLGSNKSTEETVKLFPTNCQLVVDNIQAILYEKTGKNIEVMIYGDGAFKDPVGKIWELADPVVSPAYTSGLEGTPNEVKIKYLADNNFANLEGEELKKAISEYIENKDADLTGNMVSQGTTPRRLTDLIGSLSDLTSGSGDKGTPIIFIQGYFDNYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2Q2</accession>
    <name>A0A174B2Q2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">czcD</name>
        <name evidence="8" type="ORF">ERS852471_00682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN93898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263944.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93898">
        <property type="protein sequence ID" value="CUN93898"/>
        <property type="gene ID" value="ERS852471_00682"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN93898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="32814" checksum="48CB22B6C0E45A42" modified="2016-09-07" version="1">MVEGKENKYHMIKKVLIIILIANFAVSVAKIIIGYITKSLSLSADGFHSFSDGASNIVGLISITLASKPIDNEHPYGHKKIETMASLIIGGMLVFLTYNIVVQSIQKFFNQTEITVSLESILILLSTLCINIFVAYYENKQGKKYNSSFLIADSIHTKSDIFVSIGVLTTLICIKMGVPPIIDVFVSIIVACFILYAAYEIFKDAYNVLIDSKILDEEKVRDVVMKSFNNVKDVHNIRSRGGKDYIFLDMHIKVNPDLQVSEVHSLVHNIDKVIKKKDERVIETIIHVEPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9C6</accession>
    <name>A0A174B9C6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_00717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263999.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96248">
        <property type="protein sequence ID" value="CUN96248"/>
        <property type="gene ID" value="ERS852471_00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
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        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="16"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN96248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="430" mass="48556" checksum="BA57BD01E84D0291" modified="2016-09-07" version="1">MERFKTIKTYASFSRNVQIIVISELILAAAFGIYGFLQILYLNEINIPSDKIGLIFSLGSLFSMVGFFVGPFIHMFERKNILALGCLLSSIGIGAYAVFTSYILLLLSQILTNIGLCFIQVTELQLLYSYTTPDKECCAYSYKSSVNFIASTLGTLLAGNIDRLSIFSIIGYRKLFYLSAGMTLVAFVMRLFLLPRDEKRKLDEGEIKESIGDTFKLLRGHKNIRFFAIFLFIIAIGGSAVWPYNNLIMKNYFGLSNTTMSIVSFIITTVVMMGVLAMPTIIGKIGIKRFELISLICLAATMFFLTLKLNTIPFVTILIFRCIFATLVGSSLDSSMMSYIEIENRDVFAGVKLLVNGVASAIGNFIGGFIIENINFRGIYIYGFSVLIIVILMFYLKISKIFGDRAIILERYKRNCTCKLRHRYVERRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BB50</accession>
    <name>A0A174BB50_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN98007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264063.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98007">
        <property type="protein sequence ID" value="CUN98007"/>
        <property type="gene ID" value="ERS852471_00751"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2071180at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN98007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10581" checksum="FD184956C7030A1E" modified="2016-09-07" version="1">MTRDTREELLELYTELTDCGVVFHYGNEEIDNGEITNFEIDDEDVITIELDGCETYEIELQDFIDNHSKDGVNYHSFEMGRRFDHILADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFE9</accession>
    <name>A0A174BFE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lytC_1</name>
        <name evidence="2" type="ORF">ERS852471_00778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264113.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99467">
        <property type="protein sequence ID" value="CUN99467"/>
        <property type="gene ID" value="ERS852471_00778"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="132"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="256" mass="28979" checksum="BE7159B34CD056E4" modified="2016-09-07" version="1">MEPSNFNLGYRRKMLQKRKKRRQIITSTILLSFILIPLILSIKSESNFITTIQKVDNTDNRNFVICIDAGHGDWDAGTLGISGCQEKDIVLNIALKLGDLLSVEEDIKVIYTRTSDSLPWLESANDSLKERIKISNLANADLFISLHCNSNYNDTNAKGVETWYNPSFKTNETFASYLQNKLVNLNYTTDRGLKFYEDKDDALAVLEKTTATSALVELGFISNFQDEYYLKSKPGQLACAEALYNGIIEYKRSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKD2</accession>
    <name>A0A174BKD2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264193.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01472">
        <property type="protein sequence ID" value="CUO01472"/>
        <property type="gene ID" value="ERS852471_00816"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="195" mass="22903" checksum="F670B7EDBD318095" modified="2016-09-07" version="1">MKKNKKKHWSEYMWILSTVYLFLGLFNILFAWLGLLCFSIPLLISIFGGGKTYCNSYCGRGQLLNMLGNKYKLSRNKPMPKFLKHKYFRYGFLIFFLSMFINMIFNTYLVFNGTNTLKEVITLLWAFKLPWNFADYSHVTPWIAQFAFGFYSIMITSTILGIVTMLIYKPNSWCVYCPMGTMTQGICIIKDKIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPN8</accession>
    <name>A0A174BPN8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264242.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03042">
        <property type="protein sequence ID" value="CUO03042"/>
        <property type="gene ID" value="ERS852471_00846"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="263" mass="30405" checksum="63666D16D4106B4E" modified="2016-09-07" version="1">MKRHFKLYIRFLQQYIKTLMAYRADFILGLIGFILVQSVGVIFISLIFSAIPTLSGWSFYEILFIYGFAQIPRGIDHVFTDQLWIFSWKTIAQGEFDRYLVRPLNPLFQVIVEKFQPDGFGEIIIGTMLLITSWSKLSIEVTFGKIIALIFMILCATVIYTAIKLAVTSITFWVKFAQSYMFMVYQLSSFVKYPINIYPSWIRTTLTFIIPFAFTGYYPGAYLLGRGSFFQGVIMTFLISMLSILVAYRIWLIGISRYESTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BV23</accession>
    <name>A0A174BV23_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS cluster assembly scaffold protein NifU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nifU</name>
        <name evidence="3" type="ORF">ERS852470_01580</name>
        <name evidence="2" type="ORF">ERS852471_00264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834855</strain>
            <strain evidence="2 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN64537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZV01000015">
        <property type="protein sequence ID" value="CUO15578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042395324.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="84024.ERS852471_00264"/>
    <dbReference type="EnsemblBacteria" id="CUN64537">
        <property type="protein sequence ID" value="CUN64537"/>
        <property type="gene ID" value="ERS852471_00264"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15578">
        <property type="protein sequence ID" value="CUO15578"/>
        <property type="gene ID" value="ERS852470_01580"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000095558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017787">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03419">
        <property type="entry name" value="NifU_clost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO15578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="147" mass="16277" checksum="3891726699E2123F" modified="2016-09-07" version="1">MIYTDKVMDHFRNPRNVGEIEDANGIGEVGNAKCGDIMRVYLKVEDNIIKDVKFQTFGCGSAIASSSMATEMIKGKTLEEAWELSNKAVAEALDGLPPVKMHCSVLAEEAIHKAINDYRKNAGLSTEGWEFEETDHDELHDAVHGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2V9</accession>
    <name>A0A174C2V9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO07157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264358.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07157">
        <property type="protein sequence ID" value="CUO07157"/>
        <property type="gene ID" value="ERS852471_00898"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1335440at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase_6" evidence="2">
        <location>
            <begin position="206"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="288" mass="33662" checksum="AD674B31B2DF68FF" modified="2016-09-07" version="1">MKFFNNDKYFSTHLKNFLYFIAYSIFIITLFFLFALNLSKTSNLSSNNYDLEDETFDVGSFNKNTISLELKATEYISDLFSKRNNAFLTGEVHDLSMFYNLTHTNSTYSFNNELKRISYLRDWAIERGIIFTSITSSVTIKDLKDTGDMITFKADENCEFNYVYYDDNTVNTFNVNLIHILSLNKIDNSFEIEKDYYLDFLNNTSNNYAYNLNGSHLEFSKSFNKNFVITDNLNIGDILSYKKFNFVDHKGVVCGYDSKNYPLVNSTTINSNNIPFDLGWKEKNIYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C899</accession>
    <name>A0A174C899_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08479">
        <property type="protein sequence ID" value="CUO08479"/>
        <property type="gene ID" value="ERS852471_00922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="367" mass="42479" checksum="A6E66168F8E289E2" modified="2016-09-07" version="1">MKKCIQGVKVELELIGDAEEILQRKATVGELSDITLVPAAIKISEYSKYFMPLDGLGFDEDSIYNYSSGIGSDGKLYNIDSSISWNGVLYNKKVFEEAGIEGIPRTNEEFFEVCKKIKAINKVPMAINYKNSWTMSTWIDTLPYAFNNKFEDEVILNSVNILEEGNGLYKSLNFIRTIVQEGYCEEDLLNYEWEQCKKDIKNGEVAMIFWNSNYKYQLEDIGMNVEDIGIFPLPEINEIIVYGDYRFGISKNTKYPEAAKTFFKFIFEDDRYADAVNILPISKNSDKSKNFLKEIQSFDIPVIIHDNIIDYGEDYININHEKYDSLRKLTGLNYTFVQEYIVSDNVEELSNDLNNRWNELKSKEMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCU3</accession>
    <name>A0A174CCU3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vancomycin B-type resistance protein VanW</fullName>
            <ecNumber evidence="5">3.4.24.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iga</name>
        <name evidence="5" type="ORF">ERS852471_00945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.13" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A174CCU3"/>
    <dbReference type="EnsemblBacteria" id="CUO09665">
        <property type="protein sequence ID" value="CUO09665"/>
        <property type="gene ID" value="ERS852471_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="4">
        <location>
            <begin position="385"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO09665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="489" mass="53813" checksum="609BA1067C7400BA" modified="2016-09-07" version="1">MSNNNSNGTKDFFTKHKKVIAISGVAVLAVAATVGGVMANINNKVKSWEDKVYPGVHAYGVDLSGKTKDEAVAILNDQLATLVNDKSITVTVGDKSFNIKYADIGSTINADKTAEEALAYGKEEGMFKKNSYIKDGVDTEVNTELTYDEAKLKEFEDKINTEVEIPAVDASITISYGEKYITPEVIGKKINAEELHTKLVDCIDPDPNKVETVSLELQDYSPRITAEELNKIDGIIGSFSGSYTNDGTGRVTNMQLATGYINGTLLMPGDEFSYNKTILDTTPENGYKEANTYVGSEVVPNYGGGVCQISTFLYRAVITSNIRSTIRYNHSMMVGYSEPSLDATVFEGDIDYRFINTYNSPIYIEGYMGGSTITFNVYGNTSEKGNKTYELVNNVIEKYDYTTEYVDDPTLEEGKTRTKLNGAPGYKSEGYLITYENGVEVNRELISTDVYQPMNAIVLRGTKKVEAPKPEEKPEEKPTENTEGQTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDS3</accession>
    <name>A0A174CDS3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system trehalose-specific transporter subunit IIBC</fullName>
            <ecNumber evidence="15">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">treP</name>
        <name evidence="15" type="ORF">ERS852471_00949</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="15"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264461.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09875">
        <property type="protein sequence ID" value="CUO09875"/>
        <property type="gene ID" value="ERS852471_00949"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196185at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015574">
        <property type="term" value="F:trehalose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011296">
        <property type="entry name" value="PTS_IIBC_treh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01992">
        <property type="entry name" value="PTS-IIBC-Tre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="107"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO09875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="470" mass="50500" checksum="2114E74238CC56DC" modified="2016-09-07" version="1">MGKYIDDSRALLEYVGGKDNIGAVTHCVTRMRFVLKDTSLANKDKIESLKSVKGTFVQAGQFQVIIGNTVGEFYNDFIKVSGVEGTNKDDVKDAAKSNMTFIQRLMANLAEIFSPLIPAIIVGGLILGFRNLIGDVKFFEDGTKTLIEISQFWAGTHSFLWLIGEAIFHFLPVGITWAITKKMGTTQILGIVLGITLVSPQLLNAYAVSGGGDIPFWDFGFAQVNMIGYQAQVIPAILAGFTLVYLERFFRKITPASISMIIVPFFALVPTVLIAHVVLGPIGWTIGSWISTVVYAGLTSSFRWLFAGIFGFAYAPLVITGLHHMTNAIDLQLMAQVGGTSLWPMIALSNIAQGSAVLAMIYLQRKNEEEKQVSIPACISAYLGVTEPALFGVNLKYGFPFICGMIGSGIAAIISVGSGVMANAIGIGGLPGILSIQPNSIPMFAVAMVVAIVVPFILTVVVGRKKLNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CE93</accession>
    <name>A0A174CE93_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 12 methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tehB_2</name>
        <name evidence="2" type="ORF">ERS852471_00950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO09926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264463.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09926">
        <property type="protein sequence ID" value="CUO09926"/>
        <property type="gene ID" value="ERS852471_00950"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO09926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="188" mass="21670" checksum="ABFAE605A7B63840" modified="2016-09-07" version="1">MEYMGDKNYWDSKFEIRGDSLLSPEKALVNNIGYLKTGTVLDVACGDGRNTLYLLQKGFDVTGIDFSNRALERLNAFATRAGYEVETKQVDLSGSNSLNELKNFDNIVINHYRASKEVLKDISKHINDEGILFVCGFGYKHKVDFKIRQEDLILESDFEGIKNMFNLIKYEENEDERGFFVTYILKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CF90</accession>
    <name>A0A174CF90_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferritin</fullName>
            <ecNumber evidence="5">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftnA</name>
        <name evidence="7" type="ORF">ERS852471_00955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264469.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10186">
        <property type="protein sequence ID" value="CUO10186"/>
        <property type="gene ID" value="ERS852471_00955"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="6">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO10186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="168" mass="19696" checksum="1EC398B81C7FF3AE" modified="2016-09-07" version="1">MLNENLLKALNEQVNFEFYSSYTYLAMAGYCESLDLGGFANFFRVQAKEELDHAMKLYDYVYQKNGSIELEHIDKPQPKYDGIIDVFEKGYKHEQLVTKKIYELTDIAYEEREHATISLLKWFIDEQVEEENNFNALLKKVRRVEGNPAALYLMDDELAKRVYVPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPL6</accession>
    <name>A0A174CPL6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">chrA_1</name>
        <name evidence="8" type="ORF">ERS852471_01033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264569.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15481">
        <property type="protein sequence ID" value="CUO15481"/>
        <property type="gene ID" value="ERS852471_01033"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1500307at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO15481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="492" mass="52592" checksum="87A2495B1BF45370" modified="2016-09-07" version="1">MLKRLISIFTSFFKIGVIGFGGGSALIPIVEKEIVEDKEWFNEDDYLKHTVIANITPGALPVKLGAVAGYERGGGLGSILGAYAVTLPGVILTLVLLTLFSIAGEKIAHYIEFASVGISVFIINLLLSYILKVIESGEKEGIKKYYIMICIVAFALTGGKEIRHLISSFLERDLGVLSFIVFDISTINLMIISFFMILFIGLIRTKESMIIGTSISLIFAFINGKNELVTSGGIISKILMVAIAILACYAIVRDNKKRLKKEKSRFKISKQAYISIGLFIAIPVVLFILLMILAPEGGNMGTFAGDVAISTVTSFGGGEAYVSVADGIFVQSGMVNAGDFYNKIVAIANALPGPILVKIAAGVGFILGGSLSGVLYGWLLAIFAMSVAVGACCIVAIVVLLGYDALKDSRALIMVKQFILPVVCGMLISTSLSMMIEGMKVTAGLGIAGFTALPLMILAIAMLYFVHKRYHLSDIILLCGSAVISLSMLQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CU17</accession>
    <name>A0A174CU17_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phoR_6</name>
        <name evidence="10" type="ORF">ERS852471_01029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264565.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15245">
        <property type="protein sequence ID" value="CUO15245"/>
        <property type="gene ID" value="ERS852471_01029"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="350" mass="39640" checksum="80303614C97793E5" modified="2016-09-07" version="1">MKRNKKHCNKRFNGLTILLTGVVFIIIVSTMCIVALIGSFLYNNQLFREPQHPPFLRILLFIALLSTIIGCTLTLIFGEIPLKPINKLIDATEELSNGNFDVRINFDYPKVLNNLSISFNNMASELGSAKILRNDFVNNFSHEFKTPIVSLRGFAKLLKNDNLPKEVRDEYLDIIISESDRLATLATNILNLSNIENTNIISDQHDFDLAEQIRHSILMLESKWSDKNINMNIDLDETSYYGNEELLKQVWVNLIDNAIKFTPNNGDVKIELMSFEDSVIFKVKDTGIGMTQDVKAHIFDKFYQGDTSHTTEGNGLGLTMVKKIVELHNGNIDVKSHPNKGTIIKVVLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0L5</accession>
    <name>A0A174D0L5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive alpha-beta barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264622.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18963">
        <property type="protein sequence ID" value="CUO18963"/>
        <property type="gene ID" value="ERS852471_01102"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584631at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="97" mass="11087" checksum="AE32E15FCBDD9053" modified="2016-09-07" version="1">MIKHIILWNLKEEHDNLETKLKIKNGLEALISKIPGIVEIKVNIEPIAGSNASLMLDSTFENLEALDVYQKHEEHIKVATFVRSVVSNRVCMDYEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D211</accession>
    <name>A0A174D211_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">nhaA</name>
        <name evidence="8" type="ORF">ERS852471_01111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264631.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19483">
        <property type="protein sequence ID" value="CUO19483"/>
        <property type="gene ID" value="ERS852471_01111"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO19483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="393" mass="43005" checksum="3564BF4364BC99BF" modified="2016-09-07" version="1">MEERINNQEEHNNKKKKSIVHSEAFPGILLVIATVLALILANTPLDKYYEYILKDIGFGEFNLHVLINDFLMAIFFLVVGCEIKREAVFGKLSNIKAASFPIIAAIGGMVAPAIIFTLFNYNSGFEIGAGIPLSTDIAFAIGIFTILSKRLNPSLKVFLLTLAVVDDLLSIVIIGIFYSSKFNITAIIAAIVLIVILFLIKPLNKKNRLWPYMIVGFCLWLATYFSGIHATIAGVILALSLPLTKDGNKSNDLSLRVQHGLEPLTNYFILPLFAFANTGVNLSGSINLFKEYPLMTGIVLGLVIGKPIGIMTFTYIASLFGITKKPNNASWFDVFAVSVLAGIGFTMSIFVSELAFKGSLEELNASKVSILSASVISIIFAFIVSLFNKKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D3N1</accession>
    <name>A0A174D3N1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18618">
        <property type="protein sequence ID" value="CUO18618"/>
        <property type="gene ID" value="ERS852471_01094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="189" mass="21892" checksum="24B8D2FD6C72BE60" modified="2016-09-07" version="1">MENQKIDYKLKVKEKKKRKVKRNNRALNILTSLMFIGFISIVIIFNILKVDETFSEEENRTLATMPKFTIKSFLSGDFTKEYTNYVEDNFAGKKGFVSIKSNLEKLEGKDESNSIFIGKDGQLFEKFIEASQEETDAKIAAINSFYERYSNLNMSFILTPTATKVLEEKLPKYAPNDDELDYINKVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4J8</accession>
    <name>A0A174D4J8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Platelet activating factor acetylhydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264618.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18796">
        <property type="protein sequence ID" value="CUO18796"/>
        <property type="gene ID" value="ERS852471_01098"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="112"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO18796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="29893" checksum="B7DF5E72D5AF4F92" modified="2016-09-07" version="1">MRRKILSILTLIAAFYLMATFITGMLSGVFKDKSSYGKDYLIQLENKSLDEVEDKIESYRNEILAASNTKENESTDIGDINYAKYYENTVFMGDSITEALSEFALLDDYNVICNKGDTVVKAMQNIEKLQGINPKNLVLLYGMNDVIEFDSNLSGQDSNTFKEKYIELINSIKEVLPRTNIYLVSPLSVMANAVDTNYRLTNENLNEFRLKVSEVANATGCTYIDLASMVEGKDYLHEQDGIHYKYDFYQIWLNYLTNYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7F3</accession>
    <name>A0A174D7F3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ugpQ_2</name>
        <name evidence="3" type="ORF">ERS852471_01151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21383">
        <property type="protein sequence ID" value="CUO21383"/>
        <property type="gene ID" value="ERS852471_01151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="71"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="296" mass="34247" checksum="E97447EA55F223A0" modified="2016-09-07" version="1">MRYIIKLLLIITIVIMINITLESMIDLDMSRCVNVEYKENEKTNGDEKQLLLNKYFEKEVDLDTIIRNSSYRIIAHRGYSNIAPENTIPAYKMAGEYGFYGAEADVYETKDGYYILMHDETVDRTTTGTGLVSELTLTQIKELTVDFGANISEYPMLRVPTLEEFFIVCNEYNMIPVIEIKSISNPHTFIDLIKKYGLEDKCIIISFNRKLLENIRSINKKINIQAILDITIDNINYCKKNNFDIDTSYKALRRQLVSYAHSKGVKVNTWTIDDIKTKSKVIKYGVDFITTDLFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DA85</accession>
    <name>A0A174DA85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264661.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20960">
        <property type="protein sequence ID" value="CUO20960"/>
        <property type="gene ID" value="ERS852471_01143"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030902">
        <property type="entry name" value="CLB_0814_fam"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04540">
        <property type="entry name" value="CLB_0814_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="9316" checksum="FC95D830CAA8479C" modified="2016-09-07" version="1">MRKVYRNPRELATCLKDIVDVYLEDLMTYETMESKILAIVEANRDRVYKEKNMNVNISKYLGDERVEIIDKIVKNDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DD29</accession>
    <name>A0A174DD29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation-transporting ATPase</fullName>
            <ecNumber evidence="9">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_01191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264703.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23187">
        <property type="protein sequence ID" value="CUO23187"/>
        <property type="gene ID" value="ERS852471_01191"/>
    </dbReference>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="814"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO23187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="875" mass="95058" checksum="8EFC9B7A11A65E96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DPY6</accession>
    <name>A0A174DPY6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">50S ribosomal protein L11 methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmA_1</name>
        <name evidence="1" type="ORF">ERS852471_01256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264797.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27641">
        <property type="protein sequence ID" value="CUO27641"/>
        <property type="gene ID" value="ERS852471_01256"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO27641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="286" mass="32336" checksum="9A1DE9FB688CE313" modified="2016-09-07" version="1">MFIISYKLPYALLDSTIETLAINDIYNVFYENPLEITTDDYGYGYLEKDDEDIILKVAFEESKELLDEFLITLKNILKIDYINVEENTNDYTTFESPIIHLDDTWVIAGPEENFDHKKKINFISQGAFGTGLHETTQDILRLLLNKLNLKNKSVLDIGTGSGILSIASSIAGASSVTAVDIRDVQDEVELNASLNNLTNITTIVGNILDNTSLIQDKFDWIFINIGGEETKMFMNFIKSHLNHGGNLLVSGLVEWSFEEVKSNVEKYGFTLLEKHQTNEWVTAVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVH4</accession>
    <name>A0A174DVH4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28196">
        <property type="protein sequence ID" value="CUO28196"/>
        <property type="gene ID" value="ERS852471_01269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO28196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="46" mass="5391" checksum="B2DA382FBDB2493E" modified="2016-09-07" version="1">MCKNCIFSEIKNSEYVFCKNLERCILSTEACKRFIEDNLSLVKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E097</accession>
    <name>A0A174E097_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase cobD</fullName>
            <ecNumber evidence="3">4.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobD_2</name>
        <name evidence="3" type="ORF">ERS852471_01305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.81" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO29918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264885.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29918">
        <property type="protein sequence ID" value="CUO29918"/>
        <property type="gene ID" value="ERS852471_01305"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO29918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="360" mass="41106" checksum="B6CC09FF1F2F5518" modified="2016-09-07" version="1">MNKTLTSHGGDIYTEGLLKGKELIDYSSNINLLGVPSSFYEGIKEATNLINYYPDIQYRSTKEAIIKYHKISIDNDNIILGNGAAEVLDLAISTLKSICIIAPSFSEYEISAKKYGLEIKYSYLNGDMTYNYEDILDKLKVCDGIIIANPNNPNGSNIDKEKFKFILNYCEKNGKRIIIDEAFVEFSGDKAKSFIDEVNNYKSLIIVRAITKYFALPGIRLGWAISSDKKILSKLRGKQLPWNINTFAALSLRYLLEDSEYIEKSLKVNINEKEFLIQELRKLNVINRVFDSNSNFVLCKLENSTDNELFEFALSKGILIRKCGNYRGLDSSFIRLAVKSRENNEILLDMLKCFENIRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9S9</accession>
    <name>A0A174E9S9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tilS</name>
        <name evidence="9" type="ORF">ERS852471_01384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265033.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34403">
        <property type="protein sequence ID" value="CUO34403"/>
        <property type="gene ID" value="ERS852471_01384"/>
    </dbReference>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="386"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="464" mass="54409" checksum="397A7C5F7CCDDF2C" modified="2016-09-07" version="1">MLDKVRKYIIENRLIENGDKILVALSGGPDSVCLLHILARLRSEFNLKLGAIHINHLLRGEEALEDENYTKDLCRALEVENYIERIDIATIAAKEGQSIELAGREERYKAFNKIKEKFSYDKIAVAHNSNDQAETILMRLMRGSGLDGLTGIKAKREDGIIRPILCLNRNEIEKYCEDYKLNPRIDKSNYEKIYNRNKVRLDILPYMKENFNDDIIDTLNRMAFLLQKDNEYLEEVAEMAYNKYCEEKNDAIIVSKKLFEEEKEAIITRVLKRGFKKISNSHKNFEMKHIVDIIELSKLGTNKEIHLTNGIIVQNVYGDIIFRQRKSKNEKIKDKEIYIKKEELINQFEFDNYKIDMQIINKKNNIEFSNNDLIKFFDYDKIEEGIIVRYRKDGDKMVPIGMKGTKKLKDIFINLKIPKESRDIIPIVCFDEKIAWVVDVKVSEQFKVTSNTKQILKITFKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EC50</accession>
    <name>A0A174EC50_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 3">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpt</name>
        <name evidence="5" type="ORF">ERS852471_01383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 3"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265031.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34358">
        <property type="protein sequence ID" value="CUO34358"/>
        <property type="gene ID" value="ERS852471_01383"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO34358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="179" mass="19972" checksum="A7A3875FF26454D1" modified="2016-09-07" version="1">MVNDVQEILLSEEKIALKIKELGKAISEEYAGKDLLVIGVLKGSVIFVSDLVRNISIPCEMDFMSVSSYGESSESSGVVRILKDLDNSIEGKDVIIAEDIIDSGITLEYLVDFLKGRNAKSIEIVTLLSKPARRKVDIDVKYIGFEVPDEFLVGYGLDYANRYRNLPFVGILKRSVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECC1</accession>
    <name>A0A174ECC1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">prsA_1</name>
        <name evidence="7" type="ORF">ERS852471_01402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34987">
        <property type="protein sequence ID" value="CUO34987"/>
        <property type="gene ID" value="ERS852471_01402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020631" description="Peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="6">
        <location>
            <begin position="192"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="347" mass="39644" checksum="7A05313F69303C64" modified="2016-09-07" version="1">MRRIKRIVLAAVVATMAFSMAGCNLIQKTPEAIQNTVLAKVGSEKITLGDVDTELKADIDYLKEQYGEDFESNIDDDLKARLKEVRQQVLEALVEEKVLYLEAEKRGLVPTQEELDKEVAERTAEIQEAWGGEEAFAQAKEYYGYTDETFKEFLENQVVIQKVKDDMFKDINITDDQINKYYEEHKDEYVNYGQADARHLLFQTEEEANAASEKIKSGETTFDALFTEYEGNKAKATATDATEEDQALPIAEDLGTVSHNQSNYDPLFLEGLKPLKEGEVSEPIKGYYGYHIIEATNVTETTPKEFNDELKEEIKATLENEEKNSIYENELASLKKEYKVKLYENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EDG0</accession>
    <name>A0A174EDG0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="12">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nrdG</name>
        <name evidence="14" type="ORF">ERS852471_01419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265085.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35884">
        <property type="protein sequence ID" value="CUO35884"/>
        <property type="gene ID" value="ERS852471_01419"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="169" mass="19313" checksum="B50150FDD463F55B" modified="2016-09-07" version="1">MVKEVRLSGIAYESLVNGPGMRRVFFSQGCKHNCEGCFNPETHDFSGGEVRNMDELIEDVLKNKMIKGVTFSGGDPLEQADKFAYMAKAFKDAGLNIWCYTGYTFESLLEKMENDNEVRELLENIDVLVDGKFQLDKKEDGLRFRGSSNQRIIDVKESLFRDKISILEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPP1</accession>
    <name>A0A174EPP1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">StbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265190.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38546">
        <property type="protein sequence ID" value="CUO38546"/>
        <property type="gene ID" value="ERS852471_01479"/>
    </dbReference>
    <dbReference type="OrthoDB" id="894872at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10227">
        <property type="entry name" value="ParM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040607">
        <property type="entry name" value="ALP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042051">
        <property type="entry name" value="ParM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17989">
        <property type="entry name" value="ALP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALP_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="297" mass="33530" checksum="1657ADB03FCDF663" modified="2016-09-07" version="1">MRISADIGYNTTNFIGENMEGSFLSTIKEQTHELETAKYVVEYNNKTYLIGNTDGFTSTEQSREKDAIFHLCLYTAIAASMTNTIDNNVRLITGLPAQFFAEQKLPLIRALKDRQVALKINGKFKSFTITSVIVFPQSAGLFLYDKSLVEKDTLVVDIGGGTVDITYMSQGQFKEAKTYPLGVNSMYDTLLQTLSKYGINYSNRMKAQELIDDRCIYVEGKEIDISKDIDSILSFKAKEIINSIKQSFPEQSKYSRWLFIGGGSLLLKKYLSEYKVLDDAQMINVKTYDIIGRTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ESH6</accession>
    <name>A0A174ESH6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yycG_2</name>
        <name evidence="7" type="ORF">ERS852471_01498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39556">
        <property type="protein sequence ID" value="CUO39556"/>
        <property type="gene ID" value="ERS852471_01498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="33182" checksum="3C7C9C2157F7D707" modified="2016-09-07" version="1">MGIRGNNLDENLQMIINDFEEEVNYLKQENEKKENFTLNITHDMRSHLNVIISALQFIEHNDWNIRDEKRYMNIIKRNSYKILKLINNLIDTSRLENNYYKLEKRNMDIVSMIEGTVECIERYSLEKNIQLIFDTNKEECIVSADPEAIDRIVMNLLSNAIKFSPMDSEIFVYLNIDSENINISVKDKGKGISKEEQDKIFNRFYQCSNRSAKEYIGSGIGLDLTNYLVKAHGGNISINSRENEGAEFIVTIPRILEEHIEGIDNSISSKIQMLEIEFSDIYLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F148</accession>
    <name>A0A174F148_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wcaJ_2</name>
        <name evidence="9" type="ORF">ERS852471_01539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO42516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265308.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42516">
        <property type="protein sequence ID" value="CUO42516"/>
        <property type="gene ID" value="ERS852471_01539"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO42516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="24657" checksum="20971CEC243962CC" modified="2016-09-07" version="1">MINSMKRGVSYQWLYLFFKRVIDIIAAVIGLIVLSPILLIVAILIKIDSKGPILFKQQRVGKDGNEFGMYKFRSMVINAEELKDSLEDKNEMSGPMFKMKNDPRITRVGKFIRKTSIDELPQLINVIKGEMSLVGPRPSLPKEVAQFKPWMKERLTVKPGLTCYWQVSGRNNIPFEEWMKMDIKYIKERSLWVDIKLIFRTFFVLFGDKDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1L8</accession>
    <name>A0A174F1L8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spsA_1</name>
        <name evidence="2" type="ORF">ERS852471_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO43964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265362.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43964">
        <property type="protein sequence ID" value="CUO43964"/>
        <property type="gene ID" value="ERS852471_01565"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="310" mass="36464" checksum="14DA59DCA0C9C92B" modified="2016-09-07" version="1">MDNKLKILMATYNGEKFIREQLNSILNQSYNDFELIIRDDGSKDRTVSIIQEYIEKDNRVNLLVGKNLGQTQNFNALLREVQDAEYVMFADQDDVWMEDKVELSLQKIKNIEEEKGKEYPIMVYSNLRYVDEKLNDIPNKLREINEESINTILGYNFVWGCTMLINNSLLRLSYPIGKSAQNHDYWIALTCALNGVMYNLGRETLLYRQHSNNVTGGINNYSLISKLKRLSKLFNSYNDQLNQNLEFCAKYKHLNNRLLLSYESAIKSNALKRLIIFNKLNIRRSTLKETALYYFYIFMLLKKGDLKYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4C6</accession>
    <name>A0A174F4C6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852471_01586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265402.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44934">
        <property type="protein sequence ID" value="CUO44934"/>
        <property type="gene ID" value="ERS852471_01586"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196867at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021326" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="5">
        <location>
            <begin position="257"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="507"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="641"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1626"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO44934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="1983" mass="220013" checksum="36E1FDAC1A765CB9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6V4</accession>
    <name>A0A174F6V4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">manA_2</name>
        <name evidence="7" type="ORF">ERS852471_01611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265447.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45993">
        <property type="protein sequence ID" value="CUO45993"/>
        <property type="gene ID" value="ERS852471_01611"/>
    </dbReference>
    <dbReference type="OrthoDB" id="645703at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="308" mass="35003" checksum="7FB00961E083447A" modified="2016-09-07" version="1">MYPIKFENLYYDKVWGGRDFESFRDNLPEGNIGETWDVACHPNGTGIVANGRFKGMTFNELIQNYNEEIFGKTIKDGEFPLLVKLINSNENLSVQVHPNDEYARRVENSYGKTEAWYIVDAKEGAELIVGTNGCTKDQFEEAIKNNDVENCLNRIKVKKGDAFLINSGLVHAICSGLVIAEIQQNSDITYRVYDYGRPREIHVEKSLDVIDFDLKPERLVENYEEFEGYKYTNLCKSEYFTIDKCIIDSEYKASSKEDTFTIITCVEGNGVINHKNGSEAINKGDSLLIPATLGEYEIKGQLEVLISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F836</accession>
    <name>A0A174F836_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wcaJ_3</name>
        <name evidence="4" type="ORF">ERS852471_01572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265376.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44305">
        <property type="protein sequence ID" value="CUO44305"/>
        <property type="gene ID" value="ERS852471_01572"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO44305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="22757" checksum="C16488B5272A6B7D" modified="2016-09-07" version="1">MKRSFDFLVSLVSIIILSPIIVLIALIIKFTSKGPIIFKQRRIGKDNIEFNIYKFRTMRIDTPNVPTHLLENPEQWITPIGKFMRKTSLDELPQLFNILKGDMSIVGPRPALYNQYDLKEMRTEVDVHKLVPGLTGWAQINGRDEIPLSLKVKLDKEYLDRKSFLFDIRIIVLTVLSVIKSDGVQEGKAENNNESISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFX6</accession>
    <name>A0A174FFX6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mreB_1</name>
        <name evidence="2" type="synonym">mreB</name>
        <name evidence="3" type="ORF">ERS852471_01655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO49093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265532.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49093">
        <property type="protein sequence ID" value="CUO49093"/>
        <property type="gene ID" value="ERS852471_01655"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="339" mass="36027" checksum="0C938BAC8CC46C96" modified="2016-09-07" version="1">MGFFTSNKDMGIDLGTANTLVFVKGKGVVLSEPSVVAINSDTKRPLAVGAEAKLMIGRTPGNIVAIRPLKDGVIADFEVAQTMLKKLIEKVSSKSAFTSPRIIVCYPSGVTEVERRAIEEAAKFAGARDVVLMEEPMAAAIGAGLPVGEPTGSMIVDIGGGTTEVAIISLGGIVVSKSLRVAGDELDQSIIAYVKKEFNLMIGERTAEQIKMELGSAYKIDEENATMDIKGRDMITGLPKIVTISEDQVREALKEPVYSIIESIKTTLEKTPPELAADIMEKGIMLAGGGALLKGLDELINHETNMPVHIAESPLDCVVLGAGKALDNFDELSKTQRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FI36</accession>
    <name>A0A174FI36_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO48598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265513.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48598">
        <property type="protein sequence ID" value="CUO48598"/>
        <property type="gene ID" value="ERS852471_01645"/>
    </dbReference>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="252"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO48598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="617" mass="70626" checksum="DF23E63127BFB8C9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJ28</accession>
    <name>A0A174FJ28_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system, IIB component</fullName>
            <ecNumber evidence="6">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">licB_2</name>
        <name evidence="6" type="ORF">ERS852471_01675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265564.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50183">
        <property type="protein sequence ID" value="CUO50183"/>
        <property type="gene ID" value="ERS852471_01675"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846001at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021724" evidence="4">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO50183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="10891" checksum="9FC095B15ED85738" modified="2016-09-07" version="1">MKNILLVCAAGMSTSLLVNKMKAAAKDRGLEIEINALPVSECSSVIDKVDIVLLGPQVRFQKPQVDALVNGRIPVDVIDMRLYGTMNGKAILEQVIAKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPD1</accession>
    <name>A0A174FPD1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265575.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50360">
        <property type="protein sequence ID" value="CUO50360"/>
        <property type="gene ID" value="ERS852471_01679"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879607at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO50360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="78" mass="9139" checksum="E22168A57EF77927" modified="2016-09-07" version="1">MTYTIEMNGAQMKFIREFFDNYEDDKVKLTLKDGSNRIKVVYTAESDLEKSELEGHLKTSFKTKSKYASALYYTIHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSE1</accession>
    <name>A0A174FSE1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mreB_2</name>
        <name evidence="2" type="synonym">mreB</name>
        <name evidence="3" type="ORF">ERS852471_01704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265613.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51440">
        <property type="protein sequence ID" value="CUO51440"/>
        <property type="gene ID" value="ERS852471_01704"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO51440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="36795" checksum="C9757BBA89D01A1F" modified="2016-09-07" version="1">MWFWRSGNDLGIDLGTATVLVYVKGKGILLKEPSVVAINKNNNKVLAVGEEARKMIGRTPGNIVAVRPLRDGVISDYDITERMLKEFIKKACGKGRIVAPRVMVCVPSQATEVEKRAVMDAAKNSGAKKVHIIEEPLAAAIGAGLDITKPNGAMIVDIGGGTTDIAVISLGGVVVRKSIKIAGDKFDESIIKYVRNKYKIMIGEKTAEDVKIKIGSAFKDSRKLTTTMKGRNLITGLPDEVEISTEEVREALAEPVSVIVEGVKSILEKTPPELAADIIEKGILMTGGGSLLYGLNKLIEENTGVTVEIAHNSVEAVAEGTGQVLSYIDKLGSDIFGSEINLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G0G3</accession>
    <name>A0A174G0G3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO53845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265707.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53845">
        <property type="protein sequence ID" value="CUO53845"/>
        <property type="gene ID" value="ERS852471_01753"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="37514" checksum="6DF510A11B7A51BC" modified="2016-09-07" version="1">MKLLPYSNGLRKVSMKKNRTPKEIAKLILIILSIIFVIGFVYQKISNFITKETLRQRVDYTTVDDRRMDYRLEGEGNYTVVFDGGIGGNLEQWTPVVDELSDDNVSTFVYNRRGYGYSDSGPERTPEEQAQDLKILLRKAGAPEPYILVGEGYGSLVLTSFAEQFKDSVAGVMLINPLDESYIGSKDYNKKQLITKIRRNIEKIGSNFGLTELLDKLNLDVSLDDFENSISGDQLEEFKAQRTKTKYTTAVYNEMNNLSKGLSSSQNPGVFSGIPYYLMTNSDGEKFKDLGDESLTKIYKTESETTFSGLNSTESVVNGIRYIVKELQSKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G552</accession>
    <name>A0A174G552_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrimidine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">deoA</name>
        <name evidence="12" type="ORF">ERS852471_01798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:22824"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265794.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57111">
        <property type="protein sequence ID" value="CUO57111"/>
        <property type="gene ID" value="ERS852471_01798"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047847">
        <property type="term" value="F:deoxyuridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="11">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO57111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="434" mass="46998" checksum="CF25164B1CB9C765" modified="2016-09-07" version="1">MRMYDIIMNKRKGNELSKEEIDFVVDGFTKGEIPDYQVSALLMAIFFNKMNKRETADLTMAMVKSGDEIDLSKINGIKVDKHSTGGVGDKTSICLTPLVASLDVPVAKMSGRGLGHTGGTIDKLETFEGFSVELTEEEFTNNVNSINIAIMGQSGNLVPADKKLYALRDVTATVDNMSLIASSIMSKKIASGADAIVLDVKVGDGAFMKTPEDARSLAQEMVNIGNALDRQTIAVISDMDQPLGYAIGNSLEVKEAIELLKGNGPKDLLELTLTIGSNMLVCAKKANTVEEGRKLLLQNIENGKGLEKLKEFIKAQGGDVAPIDNLDLLPKAKFIEPVVAQQDGYITKIKAEAFGLIAMELGAGRATKESEIDLAVGIVLNKKRGDKVSKGDILAYIHANNEDKIEKAKKDILSNITINDSYDLNIPVVYEIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GB54</accession>
    <name>A0A174GB54_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO58140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58140">
        <property type="protein sequence ID" value="CUO58140"/>
        <property type="gene ID" value="ERS852471_01821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009570">
        <property type="entry name" value="Spore_III_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02848">
        <property type="entry name" value="spore_III_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="66" mass="7180" checksum="6767E13E9EA78286" modified="2016-09-07" version="1">MVLDFSLLFKIGAMGVLLIIIDKVLKSGGREDISVLTNLAGIVIILIAVLSIIYKLFDSVKTLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GB76</accession>
    <name>A0A174GB76_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_01810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265818.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57725">
        <property type="protein sequence ID" value="CUO57725"/>
        <property type="gene ID" value="ERS852471_01810"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO57725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="289" mass="32339" checksum="73E9841B9702DD4B" modified="2016-09-07" version="1">MKNKEIRESLNDYLKNYFNDKGNYNKIIYDSASYSLNIGGKRIRPILMILSYSMYKNNWKDILPVAAAMEMIHTYSLIHDDLPAMDNDDLRRGMPTNHKKYGEAIAILAGDTLLNEAMSLMMSFALKNGENALKAAIEIAEAAGPEGMIGGQVVDIVSEGKKVSKDVLNYMHLKKTGELIRASVVVGAMLAGANEDDKNKLNEFGQKLGLVFQIKDDILDVEGNVNKLGKNTLSDENNDKTNFISLYGLEYCKIECKKLTENCIDILKTLSVDASDLIKLTYELLDREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCT9</accession>
    <name>A0A174GCT9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265931.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60352">
        <property type="protein sequence ID" value="CUO60352"/>
        <property type="gene ID" value="ERS852471_01872"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121327at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="338" mass="39817" checksum="11F308F3493928FE" modified="2016-09-07" version="1">MGIFDFFKNKEHKRVEDEEKIEYINEEDSYGENEEIKTIESIQYNFKIEESFDEIKSKEVEQNFEEMSPERLDYIITEEILKVIENYTDFDSVQNTVKEATRAIGVRNVEHVKDYLKGRVSKPQRWKMKYEELGQWGRTVENAVLTILYGFGEDGVDELLKISVMPSEVSFKAINLLCKLAARDIERQKIIDSIIYIMKPLREDEIIRVLTFLSQIKNSAKVDRLLELYYKKYLLDNNLEYAYDTVINRINLRGSYIEDELIFFKVLALYDGKLDADLILKGEKGIIDFTNVPDDIRVKAAVSYYSLNKDDNEINYRLLYLKDNSLDLELRKFLSTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFN3</accession>
    <name>A0A174GFN3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
            <ecNumber evidence="10">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_01858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EC" id="3.6.3.44" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265908.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59740">
        <property type="protein sequence ID" value="CUO59740"/>
        <property type="gene ID" value="ERS852471_01858"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO59740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="578" mass="65611" checksum="E4843DE78CAEF9BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQ16</accession>
    <name>A0A174GQ16_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsular polysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cotSA_1</name>
        <name evidence="3" type="ORF">ERS852471_01959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205682.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64684">
        <property type="protein sequence ID" value="CUO64684"/>
        <property type="gene ID" value="ERS852471_01959"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="369" mass="43038" checksum="3C4356FECE6F7BE8" modified="2016-09-07" version="1">MKKILYVTTVSSTINVFLVPHIKMLIDKGNRVDIACNLDQEVSKELLDYGVKLHKIDFSRNPISTNNIKAYKQILEFQKLEKYDVVNVHTPIASFVTRLALRDENVRIIYTCHGFHFYKGAPLLNWILYYPMERVASRWTDTIVTINTEDKERAEKFKLRNDGQVELMHGVGIDPKEYELIEFDKERYRKELGLKHDDFVILMIAELNKNKNHMQLINAMSLLKYKYPKIKVLCAGKGPLKEKLENKIKDLGLDKNIEFLGFRSDIKKLLNISDCITLFSLREGLGKCLLEGMIAGKPLIATDTRGPRELIENNKNGYLVQVRDYKKTAEYIENIYLDEIKRKNFSKNSLDKINQYCLENVLREVEEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H513</accession>
    <name>A0A174H513_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lioprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266314.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69984">
        <property type="protein sequence ID" value="CUO69984"/>
        <property type="gene ID" value="ERS852471_02082"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1977557at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023098" evidence="3">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO69984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="194" mass="21853" checksum="CA483AE07EB1A399" modified="2016-09-07" version="1">MKNIKLISALLVAMLLLTFVSCGNNKAENNSNSNSQNTTENTSTTPTTKEEYQNYLTERYNYYFGDSNLYDNYDIYAEDFTFNGTNEEFLTVYNNSYVELKANLENFKADLNNFVKKGTPEVDKLNAEVITDIDKAILSVDDYTSGFAEKTKDYATLGKDEVVKGLRTIGKSSHDAMDDLKNLIDDAKEKLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFI5</accession>
    <name>A0A174HFI5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO71665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266377.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71665">
        <property type="protein sequence ID" value="CUO71665"/>
        <property type="gene ID" value="ERS852471_02113"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="114" mass="12579" checksum="34827F192664218F" modified="2016-09-07" version="1">MNNRLFKLSEVAQGDDKEAKKTVVYTSDSTTAAVWVVKPNQFIPTHKHTTSDDLWICIQGTGVVYPEKDKEVPFSKGDMLLSTKDAQHGLKNTGNEDIILVSVIAPFPSDFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHN7</accession>
    <name>A0A174HHN7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_4</name>
        <name evidence="7" type="ORF">ERS852471_02131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO72425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266409.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72425">
        <property type="protein sequence ID" value="CUO72425"/>
        <property type="gene ID" value="ERS852471_02131"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO72425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="285" mass="32288" checksum="58D28EC2E81A8D04" modified="2016-09-07" version="1">MEKVKRKKKINKAPLYFILPSLIGVAVFTLLPFLDVFIRSFQSAISREFSGLENYYDIFSNAAFKLASQNTIKFVLVCIPLLLAISLAIAVFLNRFVQASQILRTAFLIPMAVPIASVVLIWNIVFHEQGVLSGVLNNFNIVGQDWMNTGYAFWVLVFSYIWKNLGYTIILWLAGLNAISKEIYESAKVDGAGELKCFTKITLPCLKPTLYTIAVLSLLNSFKVFREAYLVAGDYPDKSMYLLQHLFNNWFREMSFGKMAAASVVMAVIIFGLIMLLQRAWENQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKM1</accession>
    <name>A0A174HKM1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mglA_1</name>
        <name evidence="5" type="ORF">ERS852471_02170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73857">
        <property type="protein sequence ID" value="CUO73857"/>
        <property type="gene ID" value="ERS852471_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="34"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="286"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO73857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="535" mass="59633" checksum="0479A1963FBA77F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMF1</accession>
    <name>A0A174HMF1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kinA</name>
        <name evidence="8" type="ORF">ERS852471_02184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266508.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74328">
        <property type="protein sequence ID" value="CUO74328"/>
        <property type="gene ID" value="ERS852471_02184"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="357"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO74328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="570" mass="65489" checksum="53C81E0BB49E752A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNY6</accession>
    <name>A0A174HNY6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rdgB</name>
        <name evidence="8" type="ORF">ERS852471_02203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266522.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75017">
        <property type="protein sequence ID" value="CUO75017"/>
        <property type="gene ID" value="ERS852471_02203"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO75017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="200" mass="22335" checksum="3F700F9477AD01B8" modified="2016-09-07" version="1">MKKLIIASNNKKKIKELKAIVENLGWDVKSLADENIDIEVEEDGLTFEANAEKKAREIYDFLIKRGDKNFAVLSDDSGLEVDYLNGAPGVYSARYAGEHGNDAANNKKLLEELKNVKGKDRRGRFVCAIALIDTNGNSNIVRGTVEGLIKEELNGEGGFGYDPLFYYEPANMTFAELEASEKNKISHRANALKKIEEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HUF3</accession>
    <name>A0A174HUF3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yebN_2</name>
        <name evidence="8" type="synonym">mntP</name>
        <name evidence="9" type="ORF">ERS852471_02246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO76549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266607.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76549">
        <property type="protein sequence ID" value="CUO76549"/>
        <property type="gene ID" value="ERS852471_02246"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1857762at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="188" mass="20077" checksum="0C9837383100FCC9" modified="2016-09-07" version="1">MDLLSLVFLAVGLAMDAFAVSVALGLKIPVKEKWRIALKAGLFFGIAQGVMPLIGWILGNGFSSYIEKFDHWIAFILLSIIGGKMIYEAIHPDEDGDDEVDTGMKRMFILAIATSIDALAVGVSFAFLNVNIITAVLIIGIITLVTSAIGVIIGKIFGDLFSGKAEMVGGVILILIGVKILLEHLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFI1</accession>
    <name>A0A174IFI1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO84108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266920.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO84108">
        <property type="protein sequence ID" value="CUO84108"/>
        <property type="gene ID" value="ERS852471_02434"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO84108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="253" mass="29064" checksum="03CEB34C92DF607C" modified="2016-09-07" version="1">MGKIYVSQLFSDVEVFELLKDKDIGIEIIEFGIGSVLDKEDNGLSDYLSRMGDSIKNRNLSLHGPFLDLNPASFDSLVRSATMQRFNQVYSVAKKLNADRIIFHSCFYEDIYFKEAYVTNSIEFWKEFLADKDESIKIHIENVLEKSMDHLVEVVEGVNNDNLTICLDIGHANCYSDVPVEEWIKSLGNKIGHIHLHNNYGIKDTHEGLNKGNMDICYLLHKINEYCCNPSMTIEINDYYEINSSIEVLNKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IFX7</accession>
    <name>A0A174IFX7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marR_2</name>
        <name evidence="2" type="ORF">ERS852471_02426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266906.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83859">
        <property type="protein sequence ID" value="CUO83859"/>
        <property type="gene ID" value="ERS852471_02426"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="15858" checksum="4F976A45691D5315" modified="2016-09-07" version="1">MKHNPCGLLIKQIHDSLEKQSNNELRSKDLTMTQVTVLLLLNDAPDKKYSLKELEKVLQVAQSTAAGVISRLEQKGFVEGFSDPSDKRIKMVKLTHRGEECCLDAEKSMDDAEKRLLSGLSEEEKLIFNDLLEKVNNNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IK63</accession>
    <name>A0A174IK63_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">map_2</name>
        <name evidence="2" type="synonym">map</name>
        <name evidence="5" type="ORF">ERS852471_02515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267056.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87752">
        <property type="protein sequence ID" value="CUO87752"/>
        <property type="gene ID" value="ERS852471_02515"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO87752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="249" mass="26874" checksum="E563F913A7FB5768" modified="2016-09-07" version="1">MIIIKTEKEIDLMRQAGKIVAETLLLVEKEVKPGVTTAELDRIAEEFITKHGAKPSFKGLYGFPASLCISVNEQVVHGIPGGYVLKEGDIISVDCGAEINGFHGDAARTFAVGEISEEARRLITVTEESFFKGVEAAIVGNRLSDISHNIQNHIEANGFSVVRDFVGHGIGKTVHEDPEVPNFGRPGRGPKLVAGMALAIEPMVNMGTYRVKTAGDDWTVVTADKSLSAHYENTVVILPDGPEILTLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IQV9</accession>
    <name>A0A174IQV9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ORF">ERS852471_02505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267044.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87315">
        <property type="protein sequence ID" value="CUO87315"/>
        <property type="gene ID" value="ERS852471_02505"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO87315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="20552" checksum="EAC6A7F7AEAA1987" modified="2016-09-07" version="1">MTPRLQEKYKNEVVQAMIEKFGYKNIMEVPKLEKIVINMGVGEAKDNQKVLESAVADLTLITGQKPILTRAKKSVANFKIRENMALGCKVTLRGTKMFEFADKLVSIALPRVRDFRGVSDKAFDGRGNYSLGIKEQLIFPEIEYDKIDKVRGMDIIFVTSAKTDEEARELLRFLGMPFAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IY95</accession>
    <name>A0A174IY95_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">citS</name>
        <name evidence="5" type="ORF">ERS852471_02552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO89840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267118.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO89840">
        <property type="protein sequence ID" value="CUO89840"/>
        <property type="gene ID" value="ERS852471_02552"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1616752at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="225"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO89840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="416" mass="48497" checksum="42585DE75ED28F43" modified="2016-09-07" version="1">MISALESLCILIIYNILINERIFYHFKQYLLISLSLSLIVTPILETNFNGGVLILLIIFFLSIIVSWIDKKNKFKIFFEVCIANLILIILQFISSTAIYVILGTNVHNNIIFIPGMIIIFGFIIVFGRVIKSFKINLEEIINKQPQINILAINIILVILIVKLFSVNFIIEFNIMIQIVIIISLLIVINFFYFISVLKKNRKDKKEEIEKNIYPLIDDLMNKMRAREHEYKNHLNMLYCMVQVCNESELKEKVKDYVGSITSSEDELNKISRIENTIIKAIIFSKVQLAENYEVEFDYNIESSLENISLDNSELTVLLSNLLNNAIESSVVCKEKYVELDIYEEDKEYIIYVKNSIESIDKKLVEKMFKERYSTKGSNRGYGLLNIKNILDKHKGKLYLNVEDDYIEFNIEIPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JF46</accession>
    <name>A0A174JF46_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0751 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267381.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96268">
        <property type="protein sequence ID" value="CUO96268"/>
        <property type="gene ID" value="ERS852471_02697"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1959295at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016772">
        <property type="entry name" value="UCP020408"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10087">
        <property type="entry name" value="DUF2325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="94" mass="10532" checksum="D3E6D9698E9865B3" modified="2016-09-07" version="1">MSIVIVGGHDRMSKQYIDMCKKYNCKAKVFTQMETGFRNKIGKPDAVILLTDVVSHKLVLAAKKEADKKNITVIRNHKSTVNSLETVIKQIASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JHT6</accession>
    <name>A0A174JHT6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage II sporulation P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoIIP</name>
        <name evidence="1" type="ORF">ERS852471_02707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96710">
        <property type="protein sequence ID" value="CUO96710"/>
        <property type="gene ID" value="ERS852471_02707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010897">
        <property type="entry name" value="Spore_II_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07454">
        <property type="entry name" value="SpoIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02867">
        <property type="entry name" value="spore_II_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO96710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="36345" checksum="E2DE61E75DD4D3E8" modified="2016-09-07" version="1">MPYVQLLNFSMPIVEVQAYDEGVYIENKLDLKEVVIETLGVKNISTYGIISNEISFFKNIKIDSTFNITETATKPILPFFSPYELSENSMVMVNEEESGVFNKVSAAYDPKLKLELELEGLNKKILLHYTHSQEGYSEIGAKGNWNSFDNSLNIMGVGDVLTKELEEGYGISVINDKTIHDIDYTKCYEQSYKTVEMYLQEYGDFDLIIDLHRNSATESMTTVNLNGEDLARIMFVTAQNSPRYIANMELAQQFTSIAEGVFPTLLSGMPILDRPSGIYGNNLGLSDNMILIELGTNENSIEDAKRSTKYIARIIAEYLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JNA5</accession>
    <name>A0A174JNA5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ERS852471_02783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267534.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00111">
        <property type="protein sequence ID" value="CUP00111"/>
        <property type="gene ID" value="ERS852471_02783"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP00111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="215" mass="23681" checksum="5E30F6B8DB1CD019" modified="2016-09-07" version="1">MGSFRGILLNIILSIPAVMIAFTAQGYGKAFVADRLGDKTPRFQGRLTLNPVAHLDPIGFLMILLVGFGWTKPVETNPSAFKRGYKDSIKVAIAPPLANLIVGFLGAIIYVLFNKLFMWLPGSIFVVIAGMLGAIVTVNVGLAIFTLLPLPGLAGFDIFRAISPKNFYKYADKIYQYQLIILMLVIVLGRGILSMVSSYIINFFLYIVSFIFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JYN6</accession>
    <name>A0A174JYN6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
            <ecNumber evidence="2">2.2.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tktC</name>
        <name evidence="2" type="ORF">ERS852471_02835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.7" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000023">
        <property type="protein sequence ID" value="CUP02887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267637.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP02887">
        <property type="protein sequence ID" value="CUP02887"/>
        <property type="gene ID" value="ERS852471_02835"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP02887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="314" mass="33355" checksum="678CED5A2511A697" modified="2016-09-07" version="1">MSKKIATRESYGKALAELANTNTNIVVLDADLSKSTKTADFKAVCPERFLNMGIAEGNMMGVAAGLSTCGKIPFVSTFAMFAAGRAFEQIRNSICYPKLNVKVCATHAGLTVGEDGASHQSVEDLSLMRSIPNMVVISPSDDVETRAAIKAIAEYNGPCYVRLGRAAVNVINDEATYKFELGKGVVVSEGTDATIFATGIMVDSAIEAKDILSKEGINVKVVNIHTLKPIDEELIIKSAKETGAIVTAEEHSIIGGLGSAVAEVLAENYPVPVLRVGINDTFGESGKPDELLKAYNLTSEDIVAKVKKAINLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K163</accession>
    <name>A0A174K163_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydjZ</name>
        <name evidence="3" type="ORF">ERS852471_02869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP04581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267700.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04581">
        <property type="protein sequence ID" value="CUP04581"/>
        <property type="gene ID" value="ERS852471_02869"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP04581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="216" mass="24414" checksum="F4E21F6E12522396" modified="2016-09-07" version="1">MNKKDRINRGKFYILLTIIFVALTLLILNVKYLNGKLSIVVIANFIRKNGVFSSSIYLLIFAIKPFFVIIPSNIIAIAAGKVFGAFWGFILTMIGYYISGTVAFFLSRLLGRSFVEDLIGSRFVKLDQNLEKNGFKILFLLRLPPILPYDALSYTCGLTKIKYSDFIWASVLGVAPETLCYVILGMNFNNPFSVKFILPLIIIIFGIIFAKKLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K2E3</accession>
    <name>A0A174K2E3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP05011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267720.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05011">
        <property type="protein sequence ID" value="CUP05011"/>
        <property type="gene ID" value="ERS852471_02880"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1612763at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025436">
        <property type="entry name" value="DUF4179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040680">
        <property type="entry name" value="DUF5643"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13786">
        <property type="entry name" value="DUF4179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18705">
        <property type="entry name" value="DUF5643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4179" evidence="2">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5643" evidence="3">
        <location>
            <begin position="218"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP05011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="335" mass="37422" checksum="1447F5E59AAFE78C" modified="2016-09-07" version="1">MKDINIDDIKVSSKLDEVIKNAATEGYKDIKYKNTKRIRKSAIAATIAASFCIAIVGTVFSNEISATVKLAMFDIRNYLGINRNLDDYKTVVNSAISKEGVTVQLNEVILDKDEIIVSTTIKSDENLDNNGHISLHGNVYINGNRISSAAGGSSKQIDEYTEEVVLTYKLDKELQAGDLDIEIKYDSAYLYINDRENKVNGPWKFEFTANGDTLAANSKSIKIGNSFVLENGQKITLNEYRSNDIGQKIYYSIENKDKNNVYDLVLKGHDDLGSEVEFYSSYEEITSGVMKNQIEISSEAKILTLTPYAVAYPKESGKMSHDYKITGEEFTIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KDG2</accession>
    <name>A0A174KDG2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phoR_12</name>
        <name evidence="7" type="ORF">ERS852471_02970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267880.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08881">
        <property type="protein sequence ID" value="CUP08881"/>
        <property type="gene ID" value="ERS852471_02970"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="135"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="388" mass="45289" checksum="94E1084BD646EEBC" modified="2016-09-07" version="1">MSEGLSIEEIESVLDLIPLQIAYRNLEGKYIYCNKKYASQLGINEREKLYGKKCDEIDKIIYNINKIKKTDDEVVKRKTAIEYEEVIYINNKKYIFEINKAPIIDNNNVKGILSLKKPISYKEELDKLKEGFFYNLKHEFRTPINVIITTIQLLENKLKDFNISDYENLLMKSIERIRINSLRILKLSNNFIDLTSAYNGNTIFNFHNYDIVSTVEDICLDINNCGRFKNLRIIFDTEIEEKIISFDKVKLERIIMNLISNSIKFNDGNRIINVTIYLKDNKVNISVKDNGYGISEKKLETIFDEFSNSEKRLNKVNEGCGVGLAIVKHFVEAHKGKINVKSELGKGSEFIIEMPDVVIEDLQKNTWFTKIHNNREERITMELSDIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KDW2</accession>
    <name>A0A174KDW2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267937.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10284">
        <property type="protein sequence ID" value="CUP10284"/>
        <property type="gene ID" value="ERS852471_02995"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="156" mass="18234" checksum="5EE1BA3EF7678B51" modified="2016-09-07" version="1">MERKINVIDLEFNEELIAMDKPRQIIIHHTHNPNLTVESTHKLHIERFKWAGIGYNYFIEKNGDIFQGRGMYVGAHAKYHNKDSIGIALAGNFDETLPTEEQMKSLVDICLDFMIRYDIEPNRVIGHREIEGVEKTCPGLLFDMNKFREVLIEKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGE2</accession>
    <name>A0A174KGE2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yeiH_2</name>
        <name evidence="8" type="ORF">ERS852471_02957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP08330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267854.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08330">
        <property type="protein sequence ID" value="CUP08330"/>
        <property type="gene ID" value="ERS852471_02957"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856009at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="360" mass="37925" checksum="159601544D3798F4" modified="2016-09-07" version="1">MNKKSYFAIIVCVAIAVIATYLGGLQNIVGAPMIGLFIGMLIVNLLPTVDKDFKKGTTFAGKKFLNIGIILAGATLNFSQILGYGAKALPLIIFNICLSFTVAFFVGKKLNLSDNTCTLVGGGTSICGGTAIATLSSIIKAKETEIAYAMTSIFLFDILAALVYPYLAGALNLTANQFGFLAGTAINDTSSVAASEATYNAIHGLDLNLAITVKLTRTTMLIALAVIFTILAIRKEAKENAIATASTMSNSSAATQVAVTKQASVGQTVLKVFPWFILGFLLMAVLNTMGLFSSIEGLSGLFKTGYKFFITVALAGVGFKIQFKDLFTKGIKPIILGGCTWLAVAASSMIFIHLFASYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KJ84</accession>
    <name>A0A174KJ84_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yheH_2</name>
        <name evidence="10" type="ORF">ERS852471_03011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267965.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10861">
        <property type="protein sequence ID" value="CUP10861"/>
        <property type="gene ID" value="ERS852471_03011"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="49"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="365"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="602" mass="67518" checksum="B1C49044F1F75197" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KJ86</accession>
    <name>A0A174KJ86_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP09615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267904.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09615">
        <property type="protein sequence ID" value="CUP09615"/>
        <property type="gene ID" value="ERS852471_02978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="192" mass="21370" checksum="9EE81B71B5124255" modified="2016-09-07" version="1">MTKGEFLYNLRSNLSILPKEEIENIIEDYSMHINELLDEGESLEQILNKLGDPKEIAKQYIEELGYEDSSKEYKNTEAQYRVNESNYEAKKVKSGNIALFVFMQIVNFLFLAWVVFGVGVAVFSVGVSGIAVAGSSLAILFLNTSVNIGIRLLKTFVMAGVGILLFNAALAIAIGMVKLMIKYVKWNISLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KKB0</accession>
    <name>A0A174KKB0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioY</name>
        <name evidence="4" type="ORF">ERS852471_02988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267923.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10015">
        <property type="protein sequence ID" value="CUP10015"/>
        <property type="gene ID" value="ERS852471_02988"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691691at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP10015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="181" mass="19528" checksum="BADBB3852045BB95" modified="2016-09-07" version="1">MINIEKRNKVRDITAIGLMVALLCISSYIAFPIPFTPIMITSQTIIINLIALIMSTKNGMLSIIVFYLIGAIGLPVFSGGKSGIGTLVGPSGGYFLGFLLAVLIITLIRGKALDLKKSIMLTVLVGMVIIYICGATWMGYYNGLSFVENVKVSIIPFILGDLIKCVLASFIAIRINKIYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KN29</accession>
    <name>A0A174KN29_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RelA/SpoT domain-containing protein</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywaC</name>
        <name evidence="3" type="ORF">ERS852471_03004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000026">
        <property type="protein sequence ID" value="CUP10619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10619">
        <property type="protein sequence ID" value="CUP10619"/>
        <property type="gene ID" value="ERS852471_03004"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="69"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP10619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="227" mass="27034" checksum="E08BF5D908967111" modified="2016-09-07" version="1">MLKEIGQKIFRERIINDEFLDVVHENMRHMNELMTYYRCAIMEIETKFNVLNEEFSLQYDRNPIEHIKTRLKSPESIAKKIKKKEIEFSIEAVQEHIKDIAGVRVICSFPEDIYMLAECLLNQDDIKLIEKKDYIKNPKKSGYRSLHLIIEVPIFLQSGKKSISVEVQLRTIAMDFWASLEHKLRYKKNIDTDETEIIERELLVCSEISADLDKRMEEIRNRIENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KT85</accession>
    <name>A0A174KT85_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">melR_6</name>
        <name evidence="4" type="ORF">ERS852471_03048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268039.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12755">
        <property type="protein sequence ID" value="CUP12755"/>
        <property type="gene ID" value="ERS852471_03048"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="297" mass="34348" checksum="464BAE7532B89E86" modified="2016-09-07" version="1">MIEMKLLNDNSEVITYNFEGFPILSKQSLLSEYPNMAAPNHWHDDIEFIVILEGKMSYSINGKSYELKKGQAIFVNSAQMHYGYSCDGSDCDFICIIFNPLILSDIESIKNSYIIPICTDTSHPFFIFDSSIGWQKDFIEKLTKIHEFCSDKKDGFELQVMANLYSIFYCLYHNVKNSKDSKEYYYDKNLDSLHNMVGYIQRNYKNKITLKEIASSGNVCRSNCCEIFQSTLNKSPISYLIEYRINKSIKLLNNTSYTITEIALKCGFNSSSYFTEIFHKHLGCTPSQYRKNNTNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXE1</accession>
    <name>A0A174KXE1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP16643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16643">
        <property type="protein sequence ID" value="CUP16643"/>
        <property type="gene ID" value="ERS852471_03120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008026537" evidence="2">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="3">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP16643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="139" mass="15060" checksum="8E3857BC9CE36811" modified="2016-09-07" version="1">MKKRVIAVVLLVAMALTGCGSKGFTGEKVGEVKDEFGGKTIATVKFEEGKPVSVDIDTEQEDGTMKSEASKSGAYDMKNEPGKKWHEQVDLLEETIVKDEFNLDKITCNDEGKTDAISGVTIKINGYLDAVQDALDQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZA5</accession>
    <name>A0A174KZA5_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ORF">ERS852471_03107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15736">
        <property type="protein sequence ID" value="CUP15736"/>
        <property type="gene ID" value="ERS852471_03107"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="23"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP15736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="428" mass="47543" checksum="00EB81A5EBBDC6FA" modified="2016-09-07" version="1">MYLEKNYNLEKKKKVMRMNFNNLKDSDKEIFDLVQGELDRQKNGIELIASENFTSKAVMEAMGSYLTNKYAEGYPNKRYYGGCHIVDTVEEIARERAKKLFNAEHANVQPHSGSQANMAVYFSVLNPGDTVLGMDLSNGGHLTHGSPVNFSGKLFKFAFYGVDKITEEIDYEEVRRIAVETKPKLIVAGASAYSRIIDFKKFRDICDEVGAILMVDMAHIAGLVAAGVHPSPIPYADFVTSTTHKTLRGPRGGLILCKEKYAKELDKNIFPGMQGGPLMHVIAAKAVCFKEALEEEFVTYINDVVKNCKILSRELINFGFKIVSNGTDNHLLLVDLSNKNITGKEAEKLLDSIGITVNKNTVPNETRSPFITSGIRIGTAAVTTRGFKEEDIIEVASIINDAISNRDLDLGELKNRVTALCEKHPLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L7H2</accession>
    <name>A0A174L7H2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase IV</fullName>
            <shortName evidence="13">Pol IV</shortName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dinB_2</name>
        <name evidence="13" type="synonym">dinB</name>
        <name evidence="15" type="ORF">ERS852471_03157</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268230.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18437">
        <property type="protein sequence ID" value="CUP18437"/>
        <property type="gene ID" value="ERS852471_03157"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 13" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="5 13 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="14">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="13">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP18437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="418" mass="48007" checksum="460C93A173DAB94D" modified="2016-09-07" version="1">MGENHERIIFHVDVNSAYLSWTAVKQLQYGENDIDIRLIPSVIGGSEEDRHGIILAKSIPAKKYKIQTGESIVDALSKCPELKIYPPDYSLYMRCSNAMVELLKEYTPIIQRYSVDEVFMDVSHFKDKYMEKAYEIKTRIKEELGFAVNIGVSTNKLLAKMASDFKEKDSVHTLFKDEIKNKMWPLPVRDLFMVGKATEAKLHKLNINTIGELAKYKLEFLKPIFKSYADVIHNYANGIENSEVRANNYINIKGIGNSTTVKKDVCDREEALKILLSLTETAAMRLRKNNNMCGVIAVSIKTSGFYRYSHQKTLSNIADSTEEIFYEVTTIFDEMWNKEPIRQMGVRFSNLVGNEFYQRTFFDDKDIDKKRTLDKTIDSIRERFGDKSIIRSVFINSDIDPLSGGNGEEDYIMMSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L8A9</accession>
    <name>A0A174L8A9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268226.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18358">
        <property type="protein sequence ID" value="CUP18358"/>
        <property type="gene ID" value="ERS852471_03155"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1031512at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="248" mass="30236" checksum="F8741E10BAFD59BD" modified="2016-09-07" version="1">MEFIKIDNYNNWYIEVFNDEFQTKSLKYILEHMLIKFEIIFGRDIIDNEECYVYIDSNSACPMLHTGYDKLAIRLSTPETTYWAQVIYQLSHELCHYVLRQTSGGNETLKWFEETLCEAMSMYILKYFYETWDDCILSRNNYNYRESIKKYLEDIYNSQYGTGLAECKSEKQLRILSRLSERDRHERIRERNIVYNIFKSEPDKIKLIAEYQRYRNDIIIDFNEWKNERKDIFIEKLSEIHPRLDNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LID4</accession>
    <name>A0A174LID4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268416.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23982">
        <property type="protein sequence ID" value="CUP23982"/>
        <property type="gene ID" value="ERS852471_03261"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914020at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="23538" checksum="17BE4E94CAAFD0AE" modified="2016-09-07" version="1">MKNLINLLKLQYNSLFALKKSLLILVVMAIFFAVFQPFMIVFAGAMFLMISCYSLVFYEERSKMNYLIYSLPITTNEYILSKYIFGLLNTIISMGISVLLASIIKFIGYSSDVNSMPIYAIALSTLSIGIFFLAIVQPAALLLGTEKGRYILVFLAVLPITFSTSLVQLLPEINITISPTMIGILIVLASITILLASYFITCNRFSKKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LM85</accession>
    <name>A0A174LM85_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">nusG</name>
        <name evidence="11" type="ORF">ERS852471_03234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268365.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22539">
        <property type="protein sequence ID" value="CUP22539"/>
        <property type="gene ID" value="ERS852471_03234"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 7 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="9">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP22539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="173" mass="19765" checksum="785AFFECAB963406" modified="2016-09-07" version="1">MSERARWYVVHTYSGYENKVKANIEKTVENRNLESLIHDIQVPMEEVIEEKDGKQKVSLKKKFPGYVLIKMLMTDESWYVVRNTRGVTGFVGPGSKPVPLTDEEIENMGVVEVPVDIDLEVGESVIVISGPLREFVAIIQEINIEKRKIKALIDMFGRETLAELDFNQVEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LNW4</accession>
    <name>A0A174LNW4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268395.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23430">
        <property type="protein sequence ID" value="CUP23430"/>
        <property type="gene ID" value="ERS852471_03249"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1137664at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025062">
        <property type="entry name" value="DUF4003"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13170">
        <property type="entry name" value="DUF4003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="36620" checksum="C36FD74CD566EE42" modified="2016-09-07" version="1">MENFILNRINLTVNNYKIARMELRNDGDLLNHFASLVFSHYESEIPVERIKEIRKYIKAATPRLSIFRGDVLYLISILIASLDKSIEEELIQNMFDYMNILEEKFVEGAHLALTAYVLARYGRDKDKEVLVQKMLDTYYVLKEKYYNITQDDDYLVCALWALNDIEPDVINDFVENVFEHIADANIRSKNGIQGLANAILLNGSSGHMYRSVEFIQQLEKRNIKIANQFLPLIGILYNINPRRNVDLVEGVIEELCDQESEYEYYIDKGFRTIIAISIIAFCNNSENKVYIDELLAHGILSFINSKNKGMFSEVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LRR0</accession>
    <name>A0A174LRR0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methlytransferase</fullName>
            <ecNumber evidence="2">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiE_2</name>
        <name evidence="2" type="ORF">ERS852471_03264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000036">
        <property type="protein sequence ID" value="CUP24410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268420.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24410">
        <property type="protein sequence ID" value="CUP24410"/>
        <property type="gene ID" value="ERS852471_03264"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="35"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP24410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="190" mass="22276" checksum="9D72C334C3BC6FFC" modified="2016-09-07" version="1">MNNREFFNELAYKWDDMCHHDDKKIRKILDLADIKKESKILDIGTGTGILISYLLEKSPSKLVGLDISENMIEVAKEKYKGKNVEFVVSDIMEFNDYGYDYIFIYSAYPHFKEKEKLFEHLSKLLNPRGKVIIAHSQSRDEVNHVHSTSETVKDDILLSTDENVKIINRYLVTEKTIDNEEMYYIEAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LST2</accession>
    <name>A0A174LST2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgC_1</name>
        <name evidence="9" type="synonym">glgC</name>
        <name evidence="12" type="ORF">ERS852471_03275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000037">
        <property type="protein sequence ID" value="CUP25078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268436.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25078">
        <property type="protein sequence ID" value="CUP25078"/>
        <property type="gene ID" value="ERS852471_03275"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP25078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="385" mass="42838" checksum="C3F61EF6E9F1335C" modified="2016-09-07" version="1">MSKKEIVAMILAGGQGSRLGVLTKKLAKPAVPYGGKYRIIDFPLSNCSNSGIYTVGVLTQYKPLELNSHIGIGSPWDLDRRDGGVRILPPYQEEKGGNWYKGTANAIYQNIEFIDNHDPEYVLVLSGDHIYKMNYDKMLQFHKEKNAEATIAVIEVPLEEASRFGIMNTNDDLSIYEFEEKPAKPKSQMASMGVYIFNWKLLRQALKEDEKDKESSNDFGKNIIPKMLSQGNRLFAYPFEGYWKDVGTINSLWEANMDLLRRENGLTLYDDEWKIYSVSPVRPAQYIGKNAVVKNALVVEGCRVEGTVENSVLFEGVSVGKNTIIRDSVIMPGAKIGENVVIEKAIVGAEAIVRRSCKIGNGNNIAVIAAKEEIKSSSVLDAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M3N9</accession>
    <name>A0A174M3N9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000046">
        <property type="protein sequence ID" value="CUP28399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268512.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28399">
        <property type="protein sequence ID" value="CUP28399"/>
        <property type="gene ID" value="ERS852471_03325"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027024">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027386">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="72"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP28399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="321" mass="36034" checksum="7C939E6A2FA79A02" modified="2016-09-07" version="1">MKKIITGILSMLLIFMVGCSNNKVTYEEKEIRLITPDGLPSIAISKAMENNKTIKHITINYDVQKTSDLLVSELMKGEAELAIIPSNLALQAYKKGLDYKIVGTIGWGSLYLVSENNINDLSELKGKEIYNTGKGLTPDIIFKEILKNNNISEEEVNFSYVGAASELAPLVATGKAEYAVVPEPVLSTVMSKNPNIKIILNLNEEWAKFNDVKEGYPQSTLVIKEEFFNEIKDSGVYEELINSFKESEEFVVNNPQETATICEDLGITVNKDVINESMKNSNLRFTDISNCMEEYNVYFSTIDTESKGENNEYKPLFVEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEZ4</accession>
    <name>A0A173XEZ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN50289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055262706.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50289">
        <property type="protein sequence ID" value="CUN50289"/>
        <property type="gene ID" value="ERS852471_00028"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2052469at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="160" mass="19230" checksum="60BE52C5A10EF6AB" modified="2016-09-07" version="1">MKILKMLLSTIFLITLIACTDKINDDDIKSIIDEPLVGYIYDDNTSRYINEDNGIWYIRENEKNIIPKEEFVEKNSIINSENFIIENRENSVWELSEIQEVIVEVKDTFYSLADESYSKHYRMDKDWYYEQVKKLNNLDDIDIIQWHEPFKLPIYIDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG93</accession>
    <name>A0A173XG93_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppC_1</name>
        <name evidence="7" type="ORF">ERS852471_00020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN49877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49877">
        <property type="protein sequence ID" value="CUN49877"/>
        <property type="gene ID" value="ERS852471_00020"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN49877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="33519" checksum="5CEB610E714CA6EC" modified="2016-09-07" version="1">MNLHSNNFKIVKDKSKYIKEEKVNKNSFTIKDKSHYLSIIILLIIIIACLSSSLIMNHDPKFMDLANSNVPPNKTFYFGTDSMGRDIFSNIWYGGRVSLFIGIFSTIISTVIGVVYGSISGMAAPWIDNLMMKAIEILLSIPSILLIIFMQSIVGDSTPISMSIVIGIVSWISIAKVVRSEVRQVRNSEYILSAKIMGGRFFYILRRHLAPNFMASIMFMVVSNIASAIATESTLSFLGIGLPLDIISWGSMLSLAQNALLSNVWWVILFPGLFLIVTLICIANIGNYLRKKNIKKYNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XU17</accession>
    <name>A0A173XU17_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EcsC protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN53868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53868">
        <property type="protein sequence ID" value="CUN53868"/>
        <property type="gene ID" value="ERS852471_00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41260">
        <property type="entry name" value="PTHR41260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="268" mass="30522" checksum="01E833B167904DFD" modified="2016-09-07" version="1">MKKDINNLINKQIKIIEKKEAKLLKEPKDSYIKEKISPIKNKLEDKIPEKLQSTLELAFQKGFKLVFDKGIGIIEKTYNKESINMEYDINAYAFNKYPSKKNLKKIDKAANKKSIINKSITAIEGSGLGFLGIGLPDIPVYIAVILKSIYEISLSYGFNYSTENENAYILTLISSAVTKGDERKHYFDKLDILASNIDNNNAYDYNLEEILIDTSNKISTYMLTAKFIQGLPIVGVVGGVTNFITLQDITKIAKIKYKKRYLNKLYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWC8</accession>
    <name>A0A173XWC8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_00143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000001">
        <property type="protein sequence ID" value="CUN56251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56251">
        <property type="protein sequence ID" value="CUN56251"/>
        <property type="gene ID" value="ERS852471_00143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN56251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="210" mass="24687" checksum="8B3D8C7B5DF4D5CE" modified="2016-09-07" version="1">MIDIYTIGHSNYSIERFVEMLKKFKIDVVVDIRGTPYSKYNTQYNKEALGITLKELGFKYIYMGREFAAQRDNKIIYTWEGYSDFEKVINEPSFIEGIERLKNGLAKGYTIALLGAKQDPVTCHRFALVGRDLYKRGFNVKHIEDDLTISSQLDLEERLLERYYPNEEQITMDLLLNGEKSREEKLIDSYRKINREIGFRVENLNVTKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YK78</accession>
    <name>A0A173YK78_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN63697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63697">
        <property type="protein sequence ID" value="CUN63697"/>
        <property type="gene ID" value="ERS852471_00249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN63697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="198" mass="22851" checksum="F77F9A5E66EEEFF8" modified="2016-09-07" version="1">MTKKAKIILLSISLGVIMLISVVLFKLASGGFQFLTYATENYLEVQLEDFLSRDSGQGYNENITIIGERDYNNRTLIFYEADCQENIILSYENKGKFGKYNVYNLERIVKSDNSIAMIDIYENNRKKYIILSSLNRDDFDSINIVNKSTNKILEEIDLKNISEEDFNINELNEKSVVIEYIPKSNIEIKLELNKKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPS3</accession>
    <name>A0A173YPS3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU_1</name>
        <name evidence="3" type="ORF">ERS852471_00296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN66152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263213.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66152">
        <property type="protein sequence ID" value="CUN66152"/>
        <property type="gene ID" value="ERS852471_00296"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="218" mass="25253" checksum="38772C93CAC4FFC1" modified="2016-09-07" version="1">MTRTVLDNRMKVLISELAEMGSLVEKQLYDSIEAFKNRDMDLVENVMKNDDKVDELNKKIEEQCLKFMAMESPVATDLRKIFTTSKIVTDLERMGDYAVDICKITKRVELEPIGEECDSIWEMVDILIKMIGKSIEAFVDGNVEEAYEICKMDDKVDILYRGLFNEMLKKMAKDETMINRGAQILFASKYLERVGDHVTNICEWIIFSKKGDYVDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYW7</accession>
    <name>A0A173YYW7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">topA</name>
        <name evidence="12" type="ORF">ERS852471_00352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000002">
        <property type="protein sequence ID" value="CUN69391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263311.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69391">
        <property type="protein sequence ID" value="CUN69391"/>
        <property type="gene ID" value="ERS852471_00352"/>
    </dbReference>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN69391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="694" mass="78655" checksum="21D40E3112B28D19" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYU9</accession>
    <name>A0A173ZYU9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263620.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80809">
        <property type="protein sequence ID" value="CUN80809"/>
        <property type="gene ID" value="ERS852471_00515"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2218925at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017273" evidence="1">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="84" mass="9424" checksum="D4035A66349AE89D" modified="2016-09-07" version="1">MVNKSSKKLVLGALSAVAASVAAGVFVKKTMQNKGENKPEKEKKKKKSKNVYYTVSLNDIYNTYDDKTFSEEDMINEIKKETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1F3</accession>
    <name>A0A174A1F3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN82492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263663.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82492">
        <property type="protein sequence ID" value="CUN82492"/>
        <property type="gene ID" value="ERS852471_00539"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1993961at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="116" mass="14008" checksum="9C60BC9F1D49A9F9" modified="2016-09-07" version="1">MLEVLKLRNLRLKEQKNFNENNLCLYEHITSYIKATNLTSYEKEEILHQIMDMLLQAQYENRDVTLIFQLILDKMFYIDPYKYFINLNDVILIIIPIIILVLLGIAVYKKNYNLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A8F7</accession>
    <name>A0A174A8F7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN83668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263687.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83668">
        <property type="protein sequence ID" value="CUN83668"/>
        <property type="gene ID" value="ERS852471_00554"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2070081at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="177" mass="19866" checksum="8BA63A50B4309096" modified="2016-09-07" version="1">MEGKISSRVWDYISTILIIINGVICIFFHEEIYKWLTDVCAIVLLVKGVVKLIEGIKEDHHKDLNGKKFEVALVMIAFSIAILIKQNDAFVVVVIFWGLLGLNKSANYLNEALYKIHKKEGGIVALLKAVIEFTLSILLIFDPLGKALEHIVILGVELIIEGIFEIIKIHSGEEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9M8</accession>
    <name>A0A174A9M8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_2</name>
        <name evidence="5" type="ORF">ERS852471_00574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN85174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263725.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85174">
        <property type="protein sequence ID" value="CUN85174"/>
        <property type="gene ID" value="ERS852471_00574"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN85174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="255" mass="28478" checksum="44854F86B83FC0F1" modified="2016-09-07" version="1">MRNILKVEKVEKYYGNKDNITKAIDNISFRVDKGEFVGIMGPSGSGKTTLLNCISTIDTVTTGNIIINDKDITKMKSKQLENFRKDELGFIFQDFNLLDTLTAYENIALALTIQGVKPSLIDEKIKNVSKNLGIEEVLNKYPYQMSGGQKQRVASARAIVTDPSLILADEPTGALDSKSSRLLLDSFEKLNKDLDATILMVTHDAFTASYAHRILFIKDGKVFNELVRGNDSRKEFFNRIIEVVTLLGGDVENVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AB52</accession>
    <name>A0A174AB52_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA_2</name>
        <name evidence="7" type="ORF">ERS852471_00568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN84665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263713.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84665">
        <property type="protein sequence ID" value="CUN84665"/>
        <property type="gene ID" value="ERS852471_00568"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN84665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="101" mass="11659" checksum="1D6F6BF3067C6BAC" modified="2016-09-07" version="1">MKVINESEFVNEVKDGLVLVDFYAEWCGPCKMLSPVLEQINKENKDIKVVKVNIDNSRNIASYYQIQSIPTLVLLKDGQFIHRMIGFNPKKKIEEFIARGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACP5</accession>
    <name>A0A174ACP5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bglH_1</name>
        <name evidence="6" type="ORF">ERS852471_00590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN86401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263757.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86401">
        <property type="protein sequence ID" value="CUN86401"/>
        <property type="gene ID" value="ERS852471_00590"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN86401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="475" mass="54499" checksum="0FA1FD628DF40AF3" modified="2016-09-07" version="1">MGFRKDFLWGGATAANQCEGGYNEGGRGLANVDVSPVGKDRFAVIAGKMKMFDFDDEHFYPAKEAIDMYHRFREDIKLFGEMGFKTYRCSIAWSRIFPNGDETEPNEEGLKFYEELFKECHKYGIEPLVTITHFDCPMHLITEYGAWRNRKLVGFYENLCNVIFRRYKGLVKYWLTFNEINMILHAPFMGAGLYFEEGEDEEKIKYQAAHHELVASAIATKIAHEVDPNNKVGCMLAAGQTYPYSCNPNDVWKGMNADRENYFFIDVQSRGQYPAYALKEMERKGTMPVMEEGDLELLKNHTVDFISFSYYSSRCASADPEVNKTTEGNIFASLKNPYLDASEWGWQIDPLGLRITMNTLYDRYQKPLFIVENGLGAVDTPDENGYVEDDYRIDYLRAHIKAMRDAVVEDGVDLLGYTTWGPIDLVSAGTGEMKKRYGFIYVDRDNEGNGTLKRSKKKSFDWYKKVIASNGEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AL43</accession>
    <name>A0A174AL43_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase (Metallo-beta-lactamase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN89461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263848.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89461">
        <property type="protein sequence ID" value="CUN89461"/>
        <property type="gene ID" value="ERS852471_00640"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017742" evidence="1">
        <location>
            <begin position="27"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="50"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="290" mass="32017" checksum="BAD00A51862D58E9" modified="2016-09-07" version="1">MNNKKSIFKILSSFFMIFVLVGCGKNKENSLSNISSKAENVNVSYINVGKGDAILVQIDDKNYLIDTGLEENSEMLLEGLKAKDVDTLDGVFLTHTHKDHIGGMEAVAAAYDIEMMYRAEISENKKNGENKIDNLSEDLYLPITKLNAGDKVKITDDIYFDVIGPLVLNEDDDNDNSLVMKLVVNGKTFLFTGDMQFAEEKTLMDAGVDLSSDILKVGNHGNKDATSDEFAIAVSPKYSVITTDTTVDTNSASKRVRKALSNSEIYITEDYDRGITFTVLQDGTIEIAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AV00</accession>
    <name>A0A174AV00_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lacA</name>
        <name evidence="6" type="ORF">ERS852471_00671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055263900.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91729">
        <property type="protein sequence ID" value="CUN91729"/>
        <property type="gene ID" value="ERS852471_00671"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="5">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN91729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="202" mass="22833" checksum="A6CF56BF74319238" modified="2016-09-07" version="1">MNQKERMLAGLPYKAWLDGLKEERMENKLKIHDYNLTRPDNKKKMKEMIKNILGKTGEEVFIEQPFRCDYGKNIEVGNNFFANYNCVILDVAKVTIGENVMFAPNVSIYTAGHPIHPESRNSGYEYGIPVTIGDNVWVGGNVIITPGVTIGNNVVIGAGSVVTKDIPDNVIAVGNPCIVIREITEEHRKYYYKDKEFDVDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AWZ2</accession>
    <name>A0A174AWZ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_2</name>
        <name evidence="7" type="ORF">ERS852471_00675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000003">
        <property type="protein sequence ID" value="CUN91928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91928">
        <property type="protein sequence ID" value="CUN91928"/>
        <property type="gene ID" value="ERS852471_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN91928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="328" mass="36254" checksum="68323918491DB7C2" modified="2016-09-07" version="1">MKNSATAEVEIDEIEIRSKKSLNPVPNNIRKKSKIKKMIKENIVCTLFVLPAVAIYTFFYISSVVKSLYLSFVKWNGIPLIEKKFVGLDNFINIFKDPAFYSALKNVGVFMLVSFLVIMPFAYLLALLVSSKYINGKRFFKTVYFLPSILPTAATGLMWTLILYKSGGALNTLLMKIGMGAAQQDWLGNPKLAILTVALVNAWIFIGYNMLIFVAGLTNIPEELIEAAKIDGANGFKEQIHIVLPLMKESFKIFSVLAIVGSFKVFDIIFIMTGGGPGGATDVPVTLLYDQAFKYNNFGYGSSIGMLILIAAVICTLIVNKVFKGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BB21</accession>
    <name>A0A174BB21_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_3</name>
        <name evidence="2" type="ORF">ERS852471_00729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN96858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264018.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96858">
        <property type="protein sequence ID" value="CUN96858"/>
        <property type="gene ID" value="ERS852471_00729"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="451" mass="49639" checksum="1DF6182E22BD24B2" modified="2016-09-07" version="1">MDDISEAKVSIFSNSNLKKLIIPLVIEQILAVTVGLIDTVMVSNVGEYAVSAVSLVDTINILLINIFAALGTGGAVVAAQLIGRGSKEKARTSAKQLILITTILSVAIMIICLILNEALLRLIFGSVDSKVMYNAKIYFFYSAISYPFIALYNSGAALFRAIGNSKISMINSLIMNVINIILNSIFIFGLKLGVLGAVLATLIARVIACIIILYMLTKKKNDLYIDNYLNIKWNLKYIKKILAIGIPSGLENGMFQLGKILVQSLIATFGTYSIAANAVANNIAQMMIIPGSAIGLAMITVVGQCIGANDYEESVYNTKKLMKITFISMAILSLFLGLISPKILWIYSLSPQTTTLALKCIWIHAIVGMVIWPISFTLPNALRAANDARFTMLVSIFSMWIFRYFLSFLLARDLGLGLVGVWLAMTVDWVVRSILFIYRYRSGKWKYKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDC6</accession>
    <name>A0A174BDC6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264097.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99011">
        <property type="protein sequence ID" value="CUN99011"/>
        <property type="gene ID" value="ERS852471_00769"/>
    </dbReference>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN99011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="397" mass="44374" checksum="CBA942CA211D4CFB" modified="2016-09-07" version="1">MELSTKARKIEQSVTLMITAKAKELRAKGIDVVSFAAGEPDFNTPKNIINAAKEAMDNGNTKYTQTSGIIELKKAICKKLKDDNGLLYDDSQIVVSTGAKQSLANTFMAILNPGDEVIIPVPYWVSYPELIKLADGKPVFVNTGEENDYKYNVEALEKVITSKSKAIILNNPNNPTGTIYTKTELEAISEFAKKYDLMIISDEIYEKLTYDGNKHVSIASLSEDAKSRTIVINGFSKTYSMTGWRIGYTASSTEIAKIMTNIQSHMTSNTCSITQYAALEALNGPQEDIYHMIEEFERRRDYMYKELCNIECIKPIRPQGAFYIMINVEETIGKAINGETIKSSLDFARLLLDNENVAVIPGEAFGLDNYIRVSYATSMEAIEKGINRIREFISKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BI07</accession>
    <name>A0A174BI07_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triple helix repeat-containing collagen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUN99819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264127.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99819">
        <property type="protein sequence ID" value="CUN99819"/>
        <property type="gene ID" value="ERS852471_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="318" mass="33401" checksum="4C7CA5889CBCD8E5" modified="2016-09-07" version="1">MNKERRYYYYEDEDDNSVEEYSSNRCEENECNSNKCDEYEKCCICRGPRGPRGPQGPCGPRGPQGPCGPRGPQGPCGPRGPKGEPGPCGPCGPCGQCGHCGPCGPKGPKGDTGATGPQGPCGPRGPRGLQGPQGDIGPRGPQGIQGPQGEVGAQGPTGAQGPVGATGPQGPAGTIGDFGIVYRTVDDPNIALATGEHVPFTTDEIVGDNIVHQTNSRDILLKGNASYLVKYSVSFTAENRCSSEEGRDVEFTLTYGNGDKVAASQFAASVSEDINLNNIANHTIVNLCEDRIIRLTNLTEGRLPIRIYAATISIVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKH4</accession>
    <name>A0A174BKH4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnQ_1</name>
        <name evidence="9" type="ORF">ERS852471_00812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO01244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264184.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01244">
        <property type="protein sequence ID" value="CUO01244"/>
        <property type="gene ID" value="ERS852471_00812"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1533843at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO01244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="444" mass="46870" checksum="58C5545310822872" modified="2016-09-07" version="1">MKNLSRKDLVLVSLMLFSLFFGAGNLIFPPFLGQAAGSATWVAMAGFFITAVGFPILGVVAVAKSGGLYSLAKRVHPVFAAVFTVLIYLSIGPGLGIPRAGSLPFEMAVAPYLPESISTTLALFLFTLIFFSVAYWLSLSPAKLVDRMGKVLTPTLLVLISLIFIASIFRPIGAYGEATGEYVTSPFVKGFLEGYLTMDTIAALNFGIVISLAIKSRGVSDEKLVVSNSIKAGVIAGSLLIAIYAVLGHLGATSGGRFGTTANGAQTLTNVITYIFGKPGAVLLAIIFTLACLTTCVGLITSCSQYFATLTSKVSYKGFVRILALLSMGIANMGLTQILSISVPVLNAIYPIAIMLIVLGMMNRVFTGNAMAYRLTIIFTGVVSVVDALGQVGVGVEALTKLFERLPLYSQGLGWIVPAAVGMILGVLMKVVKENVKTEKLEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKW6</accession>
    <name>A0A174BKW6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bmrR_2</name>
        <name evidence="3" type="ORF">ERS852471_00793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264144.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00238">
        <property type="protein sequence ID" value="CUO00238"/>
        <property type="gene ID" value="ERS852471_00793"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="272" mass="32177" checksum="386026A814330746" modified="2016-09-07" version="1">MESKFSIGEIAKIHNVSVQTLRHYDKIGLLTPSYINKETGYRYYSSKDFVIIDLIKQCKSMGLSLDEIKDIIHNYTSLDSILDIMKKQKDIIDKKINELNTIKNNISFLEKRINESLEEGINVIFIKEYPKREFIKYNNTNRFTVEFEINLSKALADAERKYNNFNKELAFVTSFNDFRRDDKTIYKAMMLSFTDMISIDEKEKFIIPKGKYLTINFDDDYKDTKKYYTKIMNYIRENNIKVKGDFYEIYAMTRVGNDGREKSLGKLQIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BLT7</accession>
    <name>A0A174BLT7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_00799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO00558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264160.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00558">
        <property type="protein sequence ID" value="CUO00558"/>
        <property type="gene ID" value="ERS852471_00799"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1398160at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06920">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1850">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006635">
        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037250">
        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05031">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00725">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158911">
        <property type="entry name" value="SSF158911"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50978">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018545" evidence="7">
        <location>
            <begin position="32"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="9">
        <location>
            <begin position="51"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="9">
        <location>
            <begin position="188"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="9">
        <location>
            <begin position="365"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="9">
        <location>
            <begin position="535"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="8">
        <location>
            <begin position="657"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO00558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="688" mass="74634" checksum="942BF2F4DA246D74" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPZ9</accession>
    <name>A0A174BPZ9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper-transporting P-type ATPase</fullName>
            <ecNumber evidence="2">3.6.3.-</ecNumber>
            <ecNumber evidence="2">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">copA_2</name>
        <name evidence="2" type="ORF">ERS852471_00839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="2"/>
    <dbReference type="EC" id="3.6.3.4" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264234.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02663">
        <property type="protein sequence ID" value="CUO02663"/>
        <property type="gene ID" value="ERS852471_00839"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="69" mass="7772" checksum="C0005D768F06AE54" modified="2016-09-07" version="1">MLKKILIEGMSCNKCVAHVKEALEELKDAKSIEVNLQEKYAKVDTTSDDEEIKEKIDDAGYDVISIDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BR87</accession>
    <name>A0A174BR87_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphosugar isomerase</fullName>
            <ecNumber evidence="6">5.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">agaS</name>
        <name evidence="6" type="ORF">ERS852471_00830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:47680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:71674"/>
            <dbReference type="ChEBI" id="CHEBI:138150"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. AgaS subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO02200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264219.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02200">
        <property type="protein sequence ID" value="CUO02200"/>
        <property type="gene ID" value="ERS852471_00830"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05010">
        <property type="entry name" value="SIS_AgaS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035464">
        <property type="entry name" value="SIS_AgaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="219"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO02200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="392" mass="43947" checksum="5FFCD74B6B4BB5AF" modified="2016-09-07" version="1">MNIFNINEEQMKKTLSSFTLKEIYQQPKTWLKTLNQIKESKQAIQSFIDKVIKCDDFDVILTGAGTSEFIGNSLYSYLNKELNYKVKSYGTTDIVATPENYLSKTKPTLLVSFGRSGNSPESIGAVEAASVVCNNLYNLFITCNKDGALSKMADELDNCYAINLTDETHDQSFAMTSSFSNMYLAAYLCFNLDELEQKESMLNKVCSSTQNFLDNNYEIASKIIDEFNFERIVYLGSNTLKGISQESSLKMLELTAGKTVAVFDTPLGFRHGPKSIIDDSTLTVIYVSNDEYTYKYELDLIREISSQRKNNKLVVVSDKHSEELDTLADYTVSYNINSNANNAELGLAYITFAQTLAVLKSLSMDLTPDNPCPSGEVNRVVKGVTLYQYTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUB7</accession>
    <name>A0A174BUB7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin family phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_00868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO04217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264282.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04217">
        <property type="protein sequence ID" value="CUO04217"/>
        <property type="gene ID" value="ERS852471_00868"/>
    </dbReference>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO04217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="305" mass="34171" checksum="27F37C4E43A4BEB9" modified="2016-09-07" version="1">MKIGLVLAGGGGKGAYELGVWKALKELGISEHISVFSGTSIGAFNAVLFAMDDMEKADKLWDEVTMDKLVPISNYELIKRGIGLYLGGKNLQLAKKFLNDKLNYGAITNDGAVDIINKYLDFSKIKEKNKICYAACTKLPNYTVQYFRINDHDDETGKKMILASASLPLIYDSTEVFGEKYIDGGIVDNTPIQPVYGENCDVIIVVLLSKEATIDRSLYPNSKLIIIAPENLAENTITGTLNLDTEAKTRRIIEGYNDTINKLEPVIDLFKFINEENEKKENPILYKLYNWLKNFSNKIKGIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUC3</accession>
    <name>A0A174BUC3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GdmH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_00849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000004">
        <property type="protein sequence ID" value="CUO03198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03198">
        <property type="protein sequence ID" value="CUO03198"/>
        <property type="gene ID" value="ERS852471_00849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="108"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO03198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="262" mass="29807" checksum="1DFEECF511746B37" modified="2016-09-07" version="1">MKKHVGMRKNKVLYKLCLGVGLALIIYYIGLRLISGFVAFSSMFGLLGVILFVYGFIELKFNINIWGRISKILRRIITVLFSIGMIIFIIIEGIIIYNGHHYDKERPDYLMVLGAGLRGSKISTSLLYRLETAVEYNKLYPDVKIIVSGGQGPDEDISEAKAMKDYLVSKGIDENLIISEDKSTNTYENFLFTKKLLEDETGEEDFTVTVISNNFHMFRAKYLGEQVGFECLGYPAPSHAASSFIFYTREFFGVIKAFVFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C1T6</accession>
    <name>A0A174C1T6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructokinase</fullName>
            <ecNumber evidence="4">2.7.1.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iolC</name>
        <name evidence="4" type="ORF">ERS852471_00891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.92" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO06797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264346.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06797">
        <property type="protein sequence ID" value="CUO06797"/>
        <property type="gene ID" value="ERS852471_00891"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047590">
        <property type="term" value="F:5-dehydro-2-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO06797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="323" mass="35325" checksum="6CFF9D32AC7D8F0F" modified="2016-09-07" version="1">MKKVISIGEALIDFIPHEKGVALKDVSNFLRVAGGAPLNVAAAVSKLGGSSVMLTKLGVDGFGDHILEEIKPLGVDTSRILRTKEANTALAFVSLKEDGERDFSFYRNPSADMLLNKDEIDEETFKDGGILHFCSVSLINAPIKEAHRKAIEFAKKNKCIISFDPNVRLPLWETPELCREAILEFLPYANIVKISDEELEFITGIKDEKKALEFLLQGDVKVIIYTKGTNGAEFITGNTTVFSPSFKVVAQDTTGAGDSFIGSFLYQVADEEYSLEELVNLDEEKIKAILTFSNATAALTVCKRGAIGALPTKEEVLAMIQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAW0</accession>
    <name>A0A174CAW0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_00966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO10671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205651.1">
        <property type="nucleotide sequence ID" value="NZ_CABIXQ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10671">
        <property type="protein sequence ID" value="CUO10671"/>
        <property type="gene ID" value="ERS852471_00966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="15630" checksum="F9DAB046B2A20370" modified="2016-09-07" version="1">MGYNKLIHEYYINLSNLASLLKTLTDSYRLLIGGAFELNNIPEARTKYVKEAVNRADKLGDEIDHLIDLLEECGESYYKYVAVMNDYILKNGNTDLILTEVDSDLQFSNSPGVTSSGGFNSSPGGNYGPRPKEEPKKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CM64</accession>
    <name>A0A174CM64_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">pheA</name>
        <name evidence="22" type="ORF">ERS852471_01011</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13020">
        <property type="protein sequence ID" value="CUO13020"/>
        <property type="gene ID" value="ERS852471_01011"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011279">
        <property type="entry name" value="Chorismate_mutase_GmP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01805">
        <property type="entry name" value="CM_mono_grmpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="20">
        <location>
            <begin position="105"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="21">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CUO13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="43376" checksum="6316B515395A27A8" modified="2016-09-07" version="1">MDLSDYRKEIDEIDEEMTRLFERRMDISVKVAEYKINNKLPIFNGGREAEVIHKNVKRLKNSSYESLIRKYFNHLMELSRALQQRRFNECNNCSTEANGKIRDGKLGFQGLEGSFSEEAMIKYFGEDRETSHYETFEDVFEALKNNEIDYGILPVENTSTGAITEVYDLMNKYGFYIVGEECIKINQHLIGLEGATLDNIKEVYSHPQGFQQSSEFLKTNKQWICIPYYNTATSVKKVYDLNDITKAAIGSERAAKLYGLKILAHNINNQYENQTRFLIIGRNLEFDENSDKVSVVFSLEDEVGTLYSLLKHFAENNINLKNIESRPIKNSPWKYLLYVDFEGNLNSIEVKNALKLIQKNSGYFKLLGNYKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CSN1</accession>
    <name>A0A174CSN1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_4</name>
        <name evidence="2" type="ORF">ERS852471_01027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15149">
        <property type="protein sequence ID" value="CUO15149"/>
        <property type="gene ID" value="ERS852471_01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="457" mass="49282" checksum="C668FD9B824FF127" modified="2016-09-07" version="1">MIELNPRKILYKPSYLNEIKSILILAIPVIIENILQVLLGTTDTLFAGKLHPNAIAGIGATNLINNIYIAFFTAIGVGTTAIVSRNIGLKNKEKAIETVKQAIILTTGISLIIGLISFLFAKPILITLGATSDILEYALPYFIVVAVPCIFLSLSLILSSSLRAAGNTKTPMIASIVANVINIILNYILIFGIFDFKGLGIIGAGLATTISRVITVSILLFSLCKGKTTLKLKLFDKWIIDKGLILSISKIGVPAGIEKLIMRFGQLAYGSLIISLGTSSYVAHNIAGTIESYSYLPAMGFGVAATTLIGSQLGADNPKFAKRYGLLCNLLSTIVMIIIGSIFFIAAPSLAKMFTDDLEVQNLVVTVLRIIAIFQPFLSITLVISSALQGAGDTKLPMYSTLIGIWGIRVLFGYIFAVKFNLGLVGIWLAYSLDIVVRSIILLSRFLKGKWDEIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CT99</accession>
    <name>A0A174CT99_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO15060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264562.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15060">
        <property type="protein sequence ID" value="CUO15060"/>
        <property type="gene ID" value="ERS852471_01025"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1339744at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="80" mass="9162" checksum="20F2BB32A752BDC7" modified="2016-09-07" version="1">MNINNITDEQIWTTITYINKAYIKRALFLTGEDKIAIKEMVGKLVAKNNIKYVNQVKSMEKLMSALGVRVINVDGKFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D269</accession>
    <name>A0A174D269_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cotJA</name>
        <name evidence="1" type="ORF">ERS852471_01086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO18150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18150">
        <property type="protein sequence ID" value="CUO18150"/>
        <property type="gene ID" value="ERS852471_01086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020256">
        <property type="entry name" value="Spore_coat_CotJA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11007">
        <property type="entry name" value="CotJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO18150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="53" mass="6175" checksum="4FB1E04D8EFEE16A" modified="2016-09-07" version="1">MNTEEKKANPLKRLEYGRAYIVPQKYENLLSLTAAIKSGTIFRDLIRPYTETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D3A1</accession>
    <name>A0A174D3A1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplT</name>
        <name evidence="7" type="ORF">ERS852471_01127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264646.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20202">
        <property type="protein sequence ID" value="CUO20202"/>
        <property type="gene ID" value="ERS852471_01127"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO20202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="119" mass="13546" checksum="68E265D042522344" modified="2016-09-07" version="1">MARVKRAVNSRKNHKKVLKLAKGYYGGKSRLFKTANESVIRALRNAYVGRRLKKRDYRRLWIVRINAAARMNGMSYSRFMNGLKVAGVDMNRKMLSEIAINDAKAFADLVVLSKNALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D565</accession>
    <name>A0A174D565_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin family phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_01141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO20862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264660.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20862">
        <property type="protein sequence ID" value="CUO20862"/>
        <property type="gene ID" value="ERS852471_01141"/>
    </dbReference>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="35"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO20862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="280" mass="31821" checksum="63284B34BB264F06" modified="2016-09-07" version="1">MPSLVLEGGTFRPIFSAGVMDALLDNDIMFPYCIGVSAGITNGVSYISKQKGRNLEVIENYRNDKRYFGVSNFFKCKSIFGLDFTFDEVPNKLNIFDMDTYKSYEGKVLVGVTNAKTGKAEYLDGKELDNTAQMLRATCAIPIFFPVIKINDKEYYDGGLCDPIPIKKAIEDGNEKHLIILTRPKGYIKKLSKNNRIVARMLRKKYPNLEHILLTRHDLYNETVRFCEELEHQGKAIIIRPTAEGAIDSFEKDTTKLRAAYNHGYNMAIENLDKIKALFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6Y1</accession>
    <name>A0A174D6Y1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO19646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264634.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19646">
        <property type="protein sequence ID" value="CUO19646"/>
        <property type="gene ID" value="ERS852471_01114"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161812at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019779" evidence="1">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="171" mass="19328" checksum="DD6C99E578C10D6D" modified="2016-09-07" version="1">MKKFLIICILGISVSSLVSCGTTEVNQDNIPNKYPIDEYLEKGATLQEYTKSGDALMVDSEGQKFLAAYNSTYKPLLTDDGVLMPLIIVKNTPYYFDYEEVETALPNGYKKARISFFSGNSEKLIGESDIYKFTNSTTAYYNKDDTDTIYVKLEGKKGYQLWKTYDTLATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DCJ6</accession>
    <name>A0A174DCJ6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS_1</name>
        <name evidence="8" type="ORF">ERS852471_01196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23422">
        <property type="protein sequence ID" value="CUO23422"/>
        <property type="gene ID" value="ERS852471_01196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO23422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="275" mass="30656" checksum="641AFB6077C2CBE1" modified="2016-09-07" version="1">MQLEKILDFSVNWILTEGVKIGIGLLVLSIGWKLIKKFKKFINSLMDKKNVDKTLGNFLDTFIEVVLKILLIMIVMEIVGLKATGLAALFASAGLAIGLALQGSLSNFAGGVIILLIRPFNVGDYIEGAGHSGIVEKISIFYTCLVTPDNKQILIPNGSLANDSIVNYSSKDTRRVDLVFGVSYDDDIFKVKRILTQVVEANELIFKNPEPFISINEHGESSINFVVRAWCKTSDYWTVHFDLLEKVMVKFNEENISIPYPQMDLHLKDGKIQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DDB6</accession>
    <name>A0A174DDB6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000006">
        <property type="protein sequence ID" value="CUO22048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264679.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22048">
        <property type="protein sequence ID" value="CUO22048"/>
        <property type="gene ID" value="ERS852471_01165"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017215at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO22048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="135" mass="16144" checksum="50F9BFBE65665FE1" modified="2016-09-07" version="1">MEWNNIKTKDDIYKLMNVFGNFHDSCIKEIHYVSGAYVNENLEMNPINKRRNVTVVFQRQLSNPSEIEVVFEKISKLNLAPVNERYDCIILDSFMDIFEGEIYWADSKSFDIHDIRDYDDFTWICSENVKWRCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DL95</accession>
    <name>A0A174DL95_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">hprK</name>
        <name evidence="13" type="ORF">ERS852471_01230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO26331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264748.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26331">
        <property type="protein sequence ID" value="CUO26331"/>
        <property type="gene ID" value="ERS852471_01230"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391150at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="128"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="261"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO26331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="302" mass="33954" checksum="6D58ABB7B78C8ADB" modified="2016-09-07" version="1">MSVAVEKLIKDFDLEVLVQGDESVEISVNDINRPGLQLAGFYNYFAPERLQVIGKAEWFFLDAMQTELRKKRVEKYFSFKSNCIVITRGLEPHEEFVKAAKKNKTWLLRSNMVTTNFISKMTMYLADKFAPETRLHGVLVDVYGIGILITGESGIGKSETALELIKRGHRLVTDDAVDIREIDGSLIGTSPRITIGMLEVRGIGIIDIPSLYGVSSILQSKSINLIMHFEHWKDDGDYDRLGTNQDAQEILGVNVRKLRIPIRPGRNIAVIIEAAAVNYRHSLMSDVTPVDIIESRMAKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNK3</accession>
    <name>A0A174DNK3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852471_01244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264773.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27034">
        <property type="protein sequence ID" value="CUO27034"/>
        <property type="gene ID" value="ERS852471_01244"/>
    </dbReference>
    <dbReference type="OrthoDB" id="689314at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="408" mass="45370" checksum="4B4521231A0629C7" modified="2016-09-07" version="1">MNNDLLRKYAKLAVKTGVNIQNGDTLVINSPIETAEFARLITEEAYKSGAKDVVVHYGDQQLTKIKLENSSIETISNVPEWFGESYNYYSRIGACFISISANDPDGLKGISVDKIGAHQKARSLALKEYYENSMSNKNRWCVLSYPTMPWAKKVFPNLSDDEAFEKLFKAILDASRVTTEDPIKAWDEHNAELKKNLDFLNSKNFKSLTLTNSKGTNLTVELPYNHTWAGGLEESASGIGFNANIPTEEAFTLPKKDGVNGIVYSSKPLSYGGNLIDNFSITFKDGKVIDFTAEEGYEVLKQMLDSDEGAKYLGEVALVPYDSPISNSNLIFYNTLFDENAACHLAFGKAYPCFKDADTLTKEELEERGTNESNIHVDFMIGTEDLSITGLTESGEVIQVFKNGNWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E725</accession>
    <name>A0A174E725_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">greA_2</name>
        <name evidence="8" type="synonym">greA</name>
        <name evidence="12" type="ORF">ERS852471_01368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265001.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33543">
        <property type="protein sequence ID" value="CUO33543"/>
        <property type="gene ID" value="ERS852471_01368"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="10">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="160" mass="17880" checksum="860CBEE7751D5B97" modified="2016-09-07" version="1">MSQTKKFIMTYEGVKKLEEELEYLKTVKRKEITEKIKVALGYGDLSENSEYDEAKNDQAFTEGRILQLENMLKNAQVVDESEIPSDTVSVGSVVKLMDYDFDEEVEYTIVGSAEADPMNFKISNESPVGEALLGKKVGDVVEVTVPEGVSKFEVLGIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHY3</accession>
    <name>A0A174EHY3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">arlR_2</name>
        <name evidence="9" type="ORF">ERS852471_01455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265148.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37353">
        <property type="protein sequence ID" value="CUO37353"/>
        <property type="gene ID" value="ERS852471_01455"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO37353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="222" mass="25925" checksum="3DA3FE9A1B88A871" modified="2016-09-07" version="1">MKNILIVEDEANISDFVKGELEYEGYNVCIKEDGREGLEEALKNEYDLIILDVMLPSMNGFEICRRLKREKQSTVIMLSAKDSVMDKVNGLQIGADDYIAKPFAIEELLARIEVVFRRQDNSNNYIIKFKDITINKSSRIVKKDGNEINLTNKEYELLMILLDNKDKVVTREELLEKIWGYGYEPETNVIDVYIRYLRSKLNNENKEQYIQTVRSVGYIMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIY0</accession>
    <name>A0A174EIY0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppB_2</name>
        <name evidence="7" type="ORF">ERS852471_01461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265158.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37631">
        <property type="protein sequence ID" value="CUO37631"/>
        <property type="gene ID" value="ERS852471_01461"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="322" mass="35573" checksum="F1E331F6ABE05E8E" modified="2016-09-07" version="1">MKQYIIRRVLISIGVLFGVSFLIYGILRLMPGDFVEQMTSGNPTITAEQKELLRESYGLNGTVVEGYVSWIKNALKGDFGTSFLFQKPVTEVISSRMWTSFSLAAIAFVLQLCIAIPLGIFASTRQYTKTDYLIVFLALAGISLPSFFLAAVLQRTFSMGLGWLPLSGMVTARENFTGFRLTLDIGYHFILPITVFVITGVGSWLRYVRTNMLEVLNADYIRTARAKGLSERKVIGKHGFRNTLIPIVTFIGGTIPSLFAGAIISEGIFSIPGLGKAALDAVNNKDLPFLMGYLMFMAVLTLLGTLISDILYAVVDPRIRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENQ0</accession>
    <name>A0A174ENQ0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265176.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38119">
        <property type="protein sequence ID" value="CUO38119"/>
        <property type="gene ID" value="ERS852471_01471"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="223" mass="25208" checksum="98B1D74E0444E00F" modified="2016-09-07" version="1">MSRVGQRIKEARLKSGMSQKVLAKKLGVAEKYINDVELGRKVVQESFIDKAAKILNTDLNDINMVVTDEALMEERKTLEVNKKPKKVETTEVWNDAFASVLKSVPIFDYSLNNIKGKKELPVRSNKVEGFPQDKVLYIEIQDNEMSGFRMIKGDLAFAHLVKEPSNNGIFLVDYKGERIIRQLKSLGNSKYLLVSNGGALMTETVTVKEFEVVAKLERIEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPF7</accession>
    <name>A0A174EPF7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000008">
        <property type="protein sequence ID" value="CUO38359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070205668.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38359">
        <property type="protein sequence ID" value="CUO38359"/>
        <property type="gene ID" value="ERS852471_01476"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO38359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="92" mass="10613" checksum="F360C794B0A5069C" modified="2016-09-07" version="1">MKGNRGIFVKLNYKNIGELNSFVYDMTNGVNKDDDKYVMCAGKYDKNGWTIVFKAKSINEAQELVTRNSQKRSRKINSSIIEKEKVSIPSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6M6</accession>
    <name>A0A174F6M6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase WecB</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wecB</name>
        <name evidence="3" type="ORF">ERS852471_01578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000009">
        <property type="protein sequence ID" value="CUO44548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265387.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44548">
        <property type="protein sequence ID" value="CUO44548"/>
        <property type="gene ID" value="ERS852471_01578"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="374" mass="41862" checksum="358240CCB226BFAE" modified="2016-09-07" version="1">MERIKVLSVFGTRPEAIKMCPLVKLLEKDDRFESIVCVTAQHREMLDAVLEIFNVKPQYDLNIMSHGQTIIDVANKVLTGVDKVIKESKPDIVLVHGDTSTTLNGALAAFYNQVPIGHVEAGLRTGDIYSPFPEEANRKLTGAITTLHFAPTESNRRNLEKENITKNVYITGNTVIDALLSVIDKNHEFQDDTLNNIDFTNNKVVLLTAHRRENWGEPMKDIFAAVRHLAEENEEVQIIFPMHRNPLIRELAKSSFEGIEEKIHLIEPLEYVDFANLMSKCYLIMTDSGGIQEEAPALGKPVMVLRTETERPEAVEAGTVKLAGINKETIFNIANELVNDKEAYKKMAHAANPYGDGEACAKIVETIFSHLTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLA9</accession>
    <name>A0A174FLA9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">bglC1</name>
        <name evidence="12" type="ORF">ERS852471_01678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO50307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265573.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50307">
        <property type="protein sequence ID" value="CUO50307"/>
        <property type="gene ID" value="ERS852471_01678"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO50307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="468" mass="54203" checksum="4ED21754D559E0AD" modified="2016-09-07" version="1">MKFPKDFLFGAASASYQVEGAWNEDGKGLSNWDVFSKIPGKTFEGTNGDVAVDHYHRYKEDIKLMAEMGLESYRFSISWPRIIPNGVGEVNEKGLEFYNNVINECLKYGIVPFVTLYHWDLPQVLEEKGGWTNKETVDAFVKYAEVCFKAFGDRVKHWITFNETVVFCGLGYLAGAHPPAIVGDVKKYFQATHNVFTAHARSIELYKSLKQYGEIGITHVFSPAFSIDENPENIKATMHAREVDMHWYYDPILKGEYPEYVVKYIEKLGFTPDWTEEELAVIKSSADKNDFIGLNYYQPQRIMKNDVEEDVERTRENSTGAPGNPSFDGVYKTVMMEDKKYTKWGWEISPEGFLDGLRLLKERYGDVKMYITENGLGDEDPIIEDEIVDIPRIKYIEEHLRAVKMAIQEGINMKGYYAWSVIDLLSWLNGYKKQYGFIYVDHKNNLERKKKASFHWYKEIIETRGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSC2</accession>
    <name>A0A174FSC2_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ORF">ERS852471_01728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000010">
        <property type="protein sequence ID" value="CUO52601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032117239.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52601">
        <property type="protein sequence ID" value="CUO52601"/>
        <property type="gene ID" value="ERS852471_01728"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO52601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="68" mass="7608" checksum="539AD67D0AD3D733" modified="2016-09-07" version="1">MREGIHPNYHHDAVVKCACGNTFTTGSVKEELKVDICAKCHPFFTGKQKIVDIGGRVDKFNKKFGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6T7</accession>
    <name>A0A174G6T7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO56838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265782.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56838">
        <property type="protein sequence ID" value="CUO56838"/>
        <property type="gene ID" value="ERS852471_01792"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="207" mass="23965" checksum="D1358AE866FB9A4D" modified="2016-09-07" version="1">MKVKLDIVTGFLGSGKSVFINNIIAETITNDEKVVVIQLEDGETKIRKDFINVKTFMYDDEICKLDSFINNTIEESNCTRIIIEYNGTESFEELQYTLSIHNTRKKYKINDIYFIADANVIESYILNMGDFIIPALESSNLILINNCFDKKEDKINEIISLIKKINLNGHILKCENNEDIGNTIMKSNLFSKKRIKRLYMNIRGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9K0</accession>
    <name>A0A174G9K0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">xseA</name>
        <name evidence="9" type="ORF">ERS852471_01812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO57796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265822.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57796">
        <property type="protein sequence ID" value="CUO57796"/>
        <property type="gene ID" value="ERS852471_01812"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1371775at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="124"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="317"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO57796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="404" mass="46054" checksum="1D866300B611852D" modified="2016-09-07" version="1">MKIKTLSVSEVNNYIKKILDNDFILNNLSVKGEISNLKLHSSGHIYFSLKDSAGKINCIMFKNRAYDLRFPLEDGMEVVIRGRASVYTASGTFQIYCDEIEKEGIGELYVKFEKLKSKLAKEGYFDEDLKKDIPRDIRSIGVVTSETGAAIQDIKNVIRRRNTLVDIMLYPAQVQGNGAYKTIIEGIKYFNRKKNVDVIIIGRGGGSIEELWNFNEEELAKTIFNSNIPIVSAVGHEVDFTISDFVADIRAATPSQAGELVAPLEEDIYKRIEINKYNLNTIMQRKFEIEKNLLESYDEVLRLKSPLNKIVNGYLEVQNLKERLDFSIKNKIDKEKQKLISLNEILQARSPINILRKGYAIIKDENDNILKNVEDFSDKEEINITLRDGYVKGSFILTERGGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GAW8</accession>
    <name>A0A174GAW8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ORF">ERS852471_01855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265903.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59632">
        <property type="protein sequence ID" value="CUO59632"/>
        <property type="gene ID" value="ERS852471_01855"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="142" mass="16178" checksum="C3F7EFFB7802266B" modified="2016-09-07" version="1">MFIGEYQHSLDSKNRIVVPSKLREGLGEKFIISKGLDGCLYAYPIDEWQKFEEKLKNLPLTNRDARAFVRFFVAGATEVETDKQGRGLIPANLREYAGIEKEIVTIGALNKVEIWSKEKWESYNESDIDFDSIADKMGDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH13</accession>
    <name>A0A174GH13_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase PgcA</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgcA_1</name>
        <name evidence="11" type="ORF">ERS852471_01867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZX01000011">
        <property type="protein sequence ID" value="CUO60169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055265924.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60169">
        <property type="protein sequence ID" value="CUO60169"/>
        <property type="gene ID" value="ERS852471_01867"/>
    </dbReference>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="42"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="206"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="322"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="482"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="575" mass="64697" checksum="99C5DB6099B60A25" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GN77</accession>
    <name>A0A174GN77_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretory pathway pseudopilin PulG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_01945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO64102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266062.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64102">
        <property type="protein sequence ID" value="CUO64102"/>
        <property type="gene ID" value="ERS852471_01945"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1858396at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="130" mass="14527" checksum="734BD06AC878EA8B" modified="2016-09-07" version="1">MIKNKKSKPHSKNRAFTLIELVVVIAIVAVLAAAFTPKLSGYMDEARKVVVLDQAKRVLTAYENLNLKFNTLTEKDYIESVVSLSGSPVTLSEITKIPSKFTIEDCRNLLNTEKYDFTMTNGIVTTINSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXC3</accession>
    <name>A0A174GXC3_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_01978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000012">
        <property type="protein sequence ID" value="CUO65430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266120.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65430">
        <property type="protein sequence ID" value="CUO65430"/>
        <property type="gene ID" value="ERS852471_01978"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1536506at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="409" mass="46608" checksum="6420052C6E906277" modified="2016-09-07" version="1">MNNTQKQIIYMLSAAIRKKNVKFRSDEKINWNEVLEESEAHKVTPLIYSSINRAEALNIMDESTLNTLKKNVFKSSITQSSHIKNVASVLERFNNAGIPIIVLKGLVVRDYYPIPDLRTMCDADVLVHEEDLEKVSALMISLGFNQIKEKDDHGAHIVFYKGSTVFEVHWTLINDRFFKGDKSFEDKLWDDAMDVTVGGVKTKSLSLEDLAVHLCTHMAVHLAYSGFGVRQLTDLVVLVEKKGHLIDWKAFLNKSKECGVYTFAIAIFNICNRLFDMEMPKEIKGEKNIKNKYIEQLIQDIFDSGVHGKKSNDRVFAAEFAFDQGEGAADGSVSIIKKFMKLLFPPIRQMSDKYNYAKKFILLAPIAWIHHLIEGILNKDYNFSSKMKMATSTVSVANKRNKLLKELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYP6</accession>
    <name>A0A174GYP6_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO67892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266224.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67892">
        <property type="protein sequence ID" value="CUO67892"/>
        <property type="gene ID" value="ERS852471_02026"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="174" mass="19534" checksum="928A5989931C3D1B" modified="2016-09-07" version="1">MELIDIMSKRYSCRSFSDKKISREDLELILKSGYLAPVGKGQYDQLLITVIENKDLLNEFDKVGSTFFGGEIKHPTYSANTILLVSAKKCENELVHYCNASCIIENMILMATNLRIQSVYLLGAIEAVKNDLEFCKKLGLEDEYFPVAAMALGYDSSGIKDIAKSNKIKTSYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4T8</accession>
    <name>A0A174H4T8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF1836)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000013">
        <property type="protein sequence ID" value="CUO70052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266318.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70052">
        <property type="protein sequence ID" value="CUO70052"/>
        <property type="gene ID" value="ERS852471_02084"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1504619at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014975">
        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40056">
        <property type="entry name" value="PTHR40056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="165" mass="19095" checksum="6886DFE253D5F567" modified="2016-09-07" version="1">MEGSKFHLPRFKELPRVPLYKDQVITYLEDVAKSINVSTNEKVLTPTMLNNYVKQKVVSPPKDKKYNEKHLAYLIVVCILKQVFSLQDICNLINLQIESCPIDTAYDYFCTEVEKAIEAIFFTRDFSYPSSASVTTRESEMVRSTVMAVAHKLYIQKQLIDMENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJG6</accession>
    <name>A0A174HJG6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemX</name>
        <name evidence="9" type="ORF">ERS852471_02161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO73556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266468.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73556">
        <property type="protein sequence ID" value="CUO73556"/>
        <property type="gene ID" value="ERS852471_02161"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="8">
        <location>
            <begin position="263"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO73556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="494" mass="55141" checksum="8A22BC1887C0E658" modified="2016-09-07" version="1">MSKVYIIGTGPTDEELLTLKAVRILKKCTAVLYDRLVSNNILNYLNEECEIYYCGKEPGSHYKTQEEINESIVKLAKEGHIVGRIKGGDPYVFGRGGEEVLALVEENIDFEVVPGVTSPIAVLNYAGIPITQRAMAQSFHIVTGMSAGSSKINYEALAKETGTLVFMMGLENLDLIIENLLKNGKDANTKAAVVMRGTSSKQKKVVGTIADISQKVKEAGLKSPCIIVFGEVVSLNDKLDWYGNKPLFGANICVTRTREQSQSLKEKLRDLGAEVTEINSIRIKGTEENLKGYLDRLEDYDHIILTSVNGVNRFFDYLVKEEYDIRKIKAKFSVIGKATKKALQARGIQPFIMAREFVGEGLFKVLEPELKKDEKVLIPCSSSSRTYLKNEIESLGLKVDRVHTYDTVCGEIKNPKAFEEVDIILYTSPSTVKNMVDMVGLEKIKEKTNIAIGPQTNKALAERGVEALICKKHSEDGFLEEIVEMYRNMEDYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKQ2</accession>
    <name>A0A174HKQ2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75502">
        <property type="protein sequence ID" value="CUO75502"/>
        <property type="gene ID" value="ERS852471_02219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="634" mass="70304" checksum="65B2E459BAE19986" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HL60</accession>
    <name>A0A174HL60_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">artM_2</name>
        <name evidence="2" type="ORF">ERS852471_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000014">
        <property type="protein sequence ID" value="CUO74037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74037">
        <property type="protein sequence ID" value="CUO74037"/>
        <property type="gene ID" value="ERS852471_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="100" mass="11131" checksum="A67401BFE3CA6806" modified="2016-09-07" version="1">MIKRVGLTEEQANQKVLTLSGGQQQRVAIARALCCDNDIIIADEPTGNLDDETTVEIIKLFKDIVYKDGKTVIMVTHDKDVAKETDEIYAVKNKGIIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRD7</accession>
    <name>A0A174HRD7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serogroup A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fimA</name>
        <name evidence="2" type="ORF">ERS852471_02224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO75678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266561.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75678">
        <property type="protein sequence ID" value="CUO75678"/>
        <property type="gene ID" value="ERS852471_02224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="131" mass="14700" checksum="47AD6B7F1DD2334D" modified="2016-09-07" version="1">MIIKKYKKGFTLIELMAVVSIVVILLAITTAIINGYVDRANKVNVITQSRDVIQYSISSNIEIGSDIKLGNLVNNNVFSDYEGRLDYLQDDISINTLLAISADQDALNKIKLKDRKIVEWTGENSYKKSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HVE9</accession>
    <name>A0A174HVE9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RNA polymerase sigma factor SigI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852471_02263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000015">
        <property type="protein sequence ID" value="CUO77118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266643.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO77118">
        <property type="protein sequence ID" value="CUO77118"/>
        <property type="gene ID" value="ERS852471_02263"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687775at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024449">
        <property type="entry name" value="Anti-sigma_RsgI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12791">
        <property type="entry name" value="RsgI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51849">
        <property type="entry name" value="RSGI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RsgI N-terminal anti-sigma" evidence="8">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO77118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="330" mass="38081" checksum="989103FFA7C0C290" modified="2016-09-07" version="1">MGRDERVVYRFSSIAPLIVISDEIIEERKEQILLLKRELINYRVILKDLALMEVPYSIKNELLNIAFFIVQDVEILNNFKSKKNIPMSVVAKEFGKTRRYLEEWRDNIVTYVVILSDPKYKHIQDYLRVIEDEEKDIDVNALSILKNNKDIKGIVISSRKKNAMIMTSMGDLVKIKTNDIVSIGEEVSGTPKKLLRDYKFHISMLVAIFLVLIGMTIFRYTKVVSTVMVGTTSNIVLEVNSFNRIKNIYSRTERGSKMVETIDVLDKGIDHAIYSIIKYANENDMMPQTGIIVTVNGKPIKYGLLSKTEDYIYLEQIDFKLNNSGIEQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HZ96</accession>
    <name>A0A174HZ96_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lgt_1</name>
        <name evidence="2" type="synonym">lgt</name>
        <name evidence="3" type="ORF">ERS852471_02307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO78976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266705.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO78976">
        <property type="protein sequence ID" value="CUO78976"/>
        <property type="gene ID" value="ERS852471_02307"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO78976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="254" mass="28844" checksum="DD14AE4493AC8334" modified="2016-09-07" version="1">MNPVAFEIAGMQIRWYGIIIACGVLAAFGVTYITAKKKELNFDIIIDGFLWSFPLAIIGARVYYVAFEFENYHSIWDMINIRNGGIAIHGGLIAGLLTAYIFTRVKKVNFFEYIDVVMPGVILAQAIGRWGNFMNQEAHGGPVTEQFISKFPQFIQQGMLINGTYYHPTFLYESIWDLLVFAILIYILYKKKQQHGIVLGSYMILYSVGRFFIEGLRTDSLMFYGLRIAQIVSLTGILLGIVVIIFACKKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I063</accession>
    <name>A0A174I063_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb_1</name>
        <name evidence="5" type="ORF">ERS852471_02355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266780.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80573">
        <property type="protein sequence ID" value="CUO80573"/>
        <property type="gene ID" value="ERS852471_02355"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="152" mass="16084" checksum="9ADAEE6F4F0879E9" modified="2016-09-07" version="1">MNKVILIGRLTKDPELKYTPGTGTAVTTLTLAVDNYNSKSGERTADFIPVVIWGKQAENTAQYMSKGSQIAISGRISVRTYDAKDGTKRYVTEVVADTFNGVSFLSKGNGAGNNGGSFGGGNGYSTPASNDVFGGMSFEEDMTPVDDGDMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I4R8</accession>
    <name>A0A174I4R8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82154">
        <property type="protein sequence ID" value="CUO82154"/>
        <property type="gene ID" value="ERS852471_02383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO82154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="54" mass="6567" checksum="BA5C6B82138AFC40" modified="2016-09-07" version="1">MIKKIKFEVYENDEKEIELGNTQYELIAEELLEKYLTRLLKQDNDYILMDGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I503</accession>
    <name>A0A174I503_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS_2</name>
        <name evidence="8" type="ORF">ERS852471_02358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000016">
        <property type="protein sequence ID" value="CUO80677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO80677">
        <property type="protein sequence ID" value="CUO80677"/>
        <property type="gene ID" value="ERS852471_02358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO80677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="300" mass="33306" checksum="8F98ADF08B58D0D5" modified="2016-09-07" version="1">MNNILALAKIVSTDEGKYAWSWEGLKVNPDTLNSWIETGLSVILRIVIVFIAINLVIKIGNKIINKFVDKQVKSKMSFSLDPQKAITIGEVLKSVLKYTVYLVGVALMFYDVFAKIPVALASAGGFAIGLGAQSLVKDLINGFFLLFEDQYGVGDHVTISNFTGIVESMGIRTTVLRDFTGDLHLIPNGSILEVTNHSRGDIRFIVDVDIAYEENIDQATNVIKAVNEAFEEKHKDKLRGHIEVLGVTSLNPSGITIRVIGRAKPLSQWEMERELRKEIKEALNKSGIEIPYPKTYIVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174I7R7</accession>
    <name>A0A174I7R7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO82126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266834.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO82126">
        <property type="protein sequence ID" value="CUO82126"/>
        <property type="gene ID" value="ERS852471_02382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO82126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="118" mass="14425" checksum="E5801D2E9CDF276D" modified="2016-09-07" version="1">MNEINVEDAVIKSVRMYNDDYELFKLLAKENGITQAEFMHNLIDGFQKNNLQYKNEKYQEEKCCEGRLLDEIILEKDEEIKIRDEKISLLYKECKRYFDNDIKYRLEKLELEFKLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IDH4</accession>
    <name>A0A174IDH4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnulokinase</fullName>
            <ecNumber evidence="4">2.7.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhaB_2</name>
        <name evidence="4" type="ORF">ERS852471_02405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CYZX01000017">
        <property type="protein sequence ID" value="CUO83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055266868.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO83009">
        <property type="protein sequence ID" value="CUO83009"/>
        <property type="gene ID" value="ERS852471_02405"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02627">
        <property type="entry name" value="rhamnulo_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="471" mass="53499" checksum="39B22A2D602E70E6" modified="2016-09-07" version="1">MSYHLAIDIGASSGRHILGSLKDGKLQLEEIYRFDNGIHKIDDEYCWNLKALFKEIKNGIKKCKEVGKIPKTIGIDTWAVDFVLLDQNDEVLGNTVSYRDDRTEVVMEKAFEVIPKDMLYLHTGIQFQRFNTLYQLLAIKDKKPDILDNAKAFLMIPDYFNLLLTGQKVNEYTNATSTQLVNSFDRVWDENILKEYGINKEIFGEIKMPKTSLGNLRDELVEEFGFDMEVILPATHDTGSAFISSVCNDSDSIYVSSGTWSLIGVENRFPICVPQAMDYNFTNEGGIDYRFRFLKNIMGLWVIQEVKRNLYHKYSFSELVQEANKHKDFPSIIDVDHDRFLNPNNMIDEIKLYCMETGQRVPELVGEIAYCVFNSLAYSYKKAVGNLEEIFEKSFERINIFGGGCQNNLLNQLVANATGKEVLAGPIEATAIGNLAAQLISAGILEDLGQARNVIKESFEINIFKPNKGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IIF9</accession>
    <name>A0A174IIF9_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rplV</name>
        <name evidence="10" type="ORF">ERS852471_02498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267038.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87043">
        <property type="protein sequence ID" value="CUO87043"/>
        <property type="gene ID" value="ERS852471_02498"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO87043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="111" mass="12302" checksum="1FBFB7BAC626FC91" modified="2016-09-07" version="1">MEARAIAKYVRISPMKVGVVLDLIRGKSVNEAFAILQYTPKDAAVVINKVLKSAVANAENNHDLNVENLYVAETFVGAGPTLKRFRPMDHGKAFRINKRTSHITVVVKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174INF6</accession>
    <name>A0A174INF6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mini-ribonuclease 3</fullName>
            <shortName evidence="2">Mini-3</shortName>
            <shortName evidence="2">Mini-RNase 3</shortName>
            <ecNumber evidence="2">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mini-RNase III</fullName>
            <shortName evidence="2">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mrnC</name>
        <name evidence="4" type="ORF">ERS852471_02484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MrnC RNase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO86509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267021.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO86509">
        <property type="protein sequence ID" value="CUO86509"/>
        <property type="gene ID" value="ERS852471_02484"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939897at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005520">
        <property type="entry name" value="UCP005520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO86509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="140" mass="16210" checksum="D9FDA1E336226D12" modified="2016-09-07" version="1">MLQDYREKEFTPKDARLLNPLQLALIGDAVYELFIRNYILANNVELTAHKIHVKAIGYVKAKSQSTIMHLLEEELTEEESYIFKRGRNTKSATVPKNADVRDYRMATGFEALIGYLHLIGNYERLNYIMNKAVTTELNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IQC8</accession>
    <name>A0A174IQC8_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsQ</name>
        <name evidence="4" type="ORF">ERS852471_02502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO87209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267042.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO87209">
        <property type="protein sequence ID" value="CUO87209"/>
        <property type="gene ID" value="ERS852471_02502"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO87209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="84" mass="9942" checksum="93E65F64DE742A9B" modified="2016-09-07" version="1">MERGLRKKRIGRVVSDKMEKTIVVAVETKVRHPLYGKTVNRTTKFKAHDENNEAKINDRVLIMETRPLSKDKRWRLVEIVERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IUI4</accession>
    <name>A0A174IUI4_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdF</name>
        <name evidence="6" type="ORF">ERS852471_02533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000018">
        <property type="protein sequence ID" value="CUO88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267084.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO88529">
        <property type="protein sequence ID" value="CUO88529"/>
        <property type="gene ID" value="ERS852471_02533"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1384440at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO88529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="344" mass="40549" checksum="F2BBF8330B475494" modified="2016-09-07" version="1">MNVNRKPLFNENGDIDISKKRMINGNTTNLNDFNNMKYSWVADWYRQGMNNFWIPEEINLSQDLKDYNKLTTEERTAYDKILSFLIFLDSIQTANLSNINNYITASEVNLCLTIQAFQEAVHSQSYSYMLDTICSPEKRNEILYQWKDDEILLTRNKFIGDLYNNFIESPTKENLIKTIMANYILEGIYFYSGFMFFYNLERNGKMPGSAQEIRYINRDENTHLWLFRNIMRELQREEETLFTDELKEELREMMRCGVENEINWGHYVIGDNIQGINKNMIESYIKYLGNKRLKEIGLTPLYEGYDKNPANWVDTLSDANSVKTDFFEAKSTAYAKASTLIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IY23</accession>
    <name>A0A174IY23_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO91311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267188.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO91311">
        <property type="protein sequence ID" value="CUO91311"/>
        <property type="gene ID" value="ERS852471_02589"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029232at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO91311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="62" mass="7277" checksum="A0528F46C6D29608" modified="2016-09-07" version="1">MFTNEELAVIKDALNIADDHYKKAMELSKNNKNQMVAYNRKQKKLWLVQNKLNKILAGEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IY47</accession>
    <name>A0A174IY47_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type 3a cellulose-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_02564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267143.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90278">
        <property type="protein sequence ID" value="CUO90278"/>
        <property type="gene ID" value="ERS852471_02564"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8884at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="3">
        <location>
            <begin position="267"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="3">
        <location>
            <begin position="344"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="3">
        <location>
            <begin position="421"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="3">
        <location>
            <begin position="499"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="3">
        <location>
            <begin position="574"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO90278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="692" mass="75333" checksum="872C42EA4B71AB18" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174IZB8</accession>
    <name>A0A174IZB8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852471_02582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000019">
        <property type="protein sequence ID" value="CUO90937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267174.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO90937">
        <property type="protein sequence ID" value="CUO90937"/>
        <property type="gene ID" value="ERS852471_02582"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1262421at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO90937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="383" mass="44329" checksum="183CED209B60F8BF" modified="2016-09-07" version="1">MIGISYIYFLILALIIWIIYRVIVCKKSFKVNIFREVFINLFFLYFLIVIYLTFFKYGMLHLDLHMRSYANLIPLIETIKMFKDNFMGLGNSLYNVLGNILLFVPLGFGIPLFFKNHNRLRKVAFYGFVASFSIELLQYLTCTNFTDIDDIIFNTLGAIIGFVIFNIFILIIERTKLINLVEKLQVNYKGSLITLSSKFLLPITITTIAVFFGILYSFTVSGNQSDEDIAEAVFTYSTGNEYVESAQFFNHKLFLQDNADYFELKIADEVLQNRYVQGFSTQVQWDGNDYGYSIALINDDSKIGVIVFGKNNDAKTITINFAGDVYSQFIFEDEYFITTFPILKELPENTTIYDIYSTGESNDLKVYFNESDGTTCRHMKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6D1</accession>
    <name>A0A174J6D1_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">tig</name>
        <name evidence="14" type="ORF">ERS852471_02638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267271.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93447">
        <property type="protein sequence ID" value="CUO93447"/>
        <property type="gene ID" value="ERS852471_02638"/>
    </dbReference>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO93447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="426" mass="48370" checksum="9956C64C4AFB6529" modified="2016-09-07" version="1">MEAKMEKKDVNVVKFEVKVEAQKFNEALTRSYKKNMNKFNVPGFRKGKVPMAVVKKYYGIEVLLEDAINFAIDSSYKEVLKENNIIPVDYPQIDVVEVGEGKDFIYTAEVTVYPEVKLGEYKGLKVEKNSYEVTEEEVNKKLVEMQERNARVETKEEGIVENGNIAVIDFKGFIDGEAFQGGEGTDYELEIGSGTFIGNFEEQLVGKNVNDNVEVNVTFPENYGREELNGKPAKFEVTIKGIKVKELPALDDEFAKEVSEFDTLADLKADITKKLEETNASRIEREFEEAVILAATENANVEIPAVMIEKEIDKMVQNLEQRLQYQGLTLEQYFQFTGSDAEKMREYMKENAERKVKTDLVLEAIEKAENIDATEEEIRAKAEEVAKMYSANSDEKMVDLLINSQREALKSDVITAKAVKLLIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J6G5</accession>
    <name>A0A174J6G5_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO93238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267265.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO93238">
        <property type="protein sequence ID" value="CUO93238"/>
        <property type="gene ID" value="ERS852471_02634"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747472at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO93238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="112" mass="13230" checksum="85343A1517887397" modified="2016-09-07" version="1">MELFKIKDLEFKSEEFLDNIDEYEDLIPIIQDLQESLSYEEINCVGENDCCNSTDKNYIVEIQGYLDSEDEFYTKEELIQHGTNLENGNLDPFIIRIYKCVECGKWIIDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBY9</accession>
    <name>A0A174JBY9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000020">
        <property type="protein sequence ID" value="CUO94640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267327.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94640">
        <property type="protein sequence ID" value="CUO94640"/>
        <property type="gene ID" value="ERS852471_02667"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786584at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO94640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="164" mass="19077" checksum="1678AF9F1C9C5EE1" modified="2016-09-07" version="1">MGKTIILNLSDVILEGDILDVGESYGVIYNLSKEVFDELAIDYVEDNNKDILLSEGYDTCTIFFYLSDIWREGGRAKLIEDVTRFVKKGGNIYIWDINKEIGKVFNNKIRAVLPSEKIKEFEFKNLNIMSKSNLEDTKKLLEPNYKITEEKIWEDIYFVKGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDA4</accession>
    <name>A0A174JDA4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3793)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO96226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267379.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96226">
        <property type="protein sequence ID" value="CUO96226"/>
        <property type="gene ID" value="ERS852471_02696"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721190at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024523">
        <property type="entry name" value="DUF3793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12672">
        <property type="entry name" value="DUF3793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO96226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="212" mass="24824" checksum="08790EE6162FE5A9" modified="2016-09-07" version="1">MSTIGFYKSLNNMEERECIEKFLIFNASLVISEAKPSATITLKKGIDSIYEKWCKYGEKFLKSIDINYISLRECENALIILVYDKKQLSNYIFKQENKHFLNKIGYSDENDLDIYLEKLKRRYNEFNCPHELGVFLGYPLEDVKDFMNCSTKKCLACGYWRVYNDYSTAKEVFNTYDMIKEKTVKYILKGDSAHKVFCNLKNIISELDGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JKC4</accession>
    <name>A0A174JKC4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_02749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000021">
        <property type="protein sequence ID" value="CUO98307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267474.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO98307">
        <property type="protein sequence ID" value="CUO98307"/>
        <property type="gene ID" value="ERS852471_02749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO98307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="90" mass="10861" checksum="D10F3EB3C6F4E798" modified="2016-09-07" version="1">MNTSEKRIYDDVIRRLRSYSGNDMWECILEEQDGEYNIALPITMDILELIINYEKGKKEIDERVIEFYCGCYEVLYDLDDSINWNNYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JLK4</accession>
    <name>A0A174JLK4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duf378 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267553.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00603">
        <property type="protein sequence ID" value="CUP00603"/>
        <property type="gene ID" value="ERS852471_02795"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1970874at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37304">
        <property type="entry name" value="PTHR37304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP00603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="69" mass="7696" checksum="3FDF177D190B2421" modified="2016-09-07" version="1">MKLLDTIILAIIILGSINWGLIGIFQFDLISNIFGDMSVFTRIIYTLVGICGLYAISFFMKSKSTSNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQJ7</accession>
    <name>A0A174JQJ7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_02764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99309">
        <property type="protein sequence ID" value="CUO99309"/>
        <property type="gene ID" value="ERS852471_02764"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO99309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="316" mass="37004" checksum="05B997798A38C7C4" modified="2016-09-07" version="1">MKFIEKLVDDIYKSSKIPFNLNIDGFGIYSTPLFDKSQNYLTKNFKFENTKCCIKVNAAFSAILDLLIFCIKDKLEDGFLHKRDIILSLLKGEEIEPEILKATLPALTKEFYLVSIYAENNIESIYDYIKECYTDSEVEVVIYKGNIIIIGELEDARDHMESIKETIDNTFSGKYYISYSKVLDLNKINKEFEDNIAKIELAKKYNFNESIIDDRNMIFEGIIDSVSDYVKEDVFEKVNNGFLKLDTEMIKTIEVFFKCGLNLSDAAKELYIHRNTLIYRLDKIEKYTSYDIREFNNAVIFKLVFFLWKEKKTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JQX1</accession>
    <name>A0A174JQX1_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lytG</name>
        <name evidence="3" type="ORF">ERS852471_02771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99545">
        <property type="protein sequence ID" value="CUO99545"/>
        <property type="gene ID" value="ERS852471_02771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="148"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO99545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="315" mass="36203" checksum="7CBC612DE37792C6" modified="2016-09-07" version="1">MNEKLIYNGINNYGYKTTKKKVKLYPFIVVIIFTALILFGRNIFFTRTDFDTLGYDKIKYYIDVTDNVSEGKAQVNWQEVAAINEVLNDGKEDELVSKIAKVFLKNGENGEYTLFTVDEVLERLKVNNEEEEKVKAFLNEINDNTLYKDLYKDEAKMTFINEIYPAALDNYYNYGILPSITMAQAILESGWGESELALEHNNIFGIKADSRWDGAIATMTTKENYDDIIEANFRKYDNILQSIADHGEFLNENERYRVNGLFDGKEYKSQAQALENAGYSTAEDENGEKIYADKLINVIQKYNLMIFDSKAKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JRG8</accession>
    <name>A0A174JRG8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine transport system permease protein PotC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ydcV</name>
        <name evidence="7" type="ORF">ERS852471_02774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUO99760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267516.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99760">
        <property type="protein sequence ID" value="CUO99760"/>
        <property type="gene ID" value="ERS852471_02774"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO99760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="270" mass="30197" checksum="B0DB5279A01E3A5C" modified="2016-09-07" version="1">MVKKLESFIKRFYLILIFIFLYTPIITLMVFSFNDSKSMGKWNGFTLRWYSELFQNARIMNALKYTLIIAVVASIIATIIGTLAAIGIHRMKGLPKKTLLNINYLPVLNPDIVTGISLMSLFIFLKPLLNIEFGFLTMLLAHITFNIPYVILSVLPKLKQMPANITDAALDLGATPGYAMRKIILPQIKPGIFAGLLMAFTMSIDDFVISFFTTGPGVTNLSIEIYSMARKGINPSINALSTLMFVTVLILLLIVNRKEFTSRGGKVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JRI0</accession>
    <name>A0A174JRI0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbonic anhydrase/acetyltransferase, isoleucine patch superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yrdA</name>
        <name evidence="1" type="ORF">ERS852471_02799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000022">
        <property type="protein sequence ID" value="CUP00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267561.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00776">
        <property type="protein sequence ID" value="CUP00776"/>
        <property type="gene ID" value="ERS852471_02799"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="18232" checksum="922ABC4AE4BAD568" modified="2016-09-07" version="1">MVKEFYGKYPNINETAYISESVDIIGDVLIKDNVNIWFGARLRADMNKIVIGENTNIQENSVIHIDVDYETIIGRNVTIGHGAIIHGCNIADNVLVGMGSIILNGARIGKNTIIGAGSLITQGKSFEEGVLVLGNPAKVIRKLTDEEIKSIQKSADNYVALSNKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K982</accession>
    <name>A0A174K982_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yfhA</name>
        <name evidence="8" type="ORF">ERS852471_02936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000025">
        <property type="protein sequence ID" value="CUP07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267819.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07421">
        <property type="protein sequence ID" value="CUP07421"/>
        <property type="gene ID" value="ERS852471_02936"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="335" mass="36093" checksum="A1C7343B17AC4C84" modified="2016-09-07" version="1">MKKRKYKITLLILLALLVISFAVTLCWGTYKVSPLEVINTLLGNGTKLQNTAILSIRLPRMLVGISVAVALSTAGAILQTITKNDLADTGIIGINAGASVAAILFITYQTANYYSELGGLSIFVLPIMAVIGAGIAAFMIYMLSSRKGIRPKRLLLIGIGLNAGLNAFITFFTFRGGVGDYNKVLVWTSGSLWGSGWSYAKVIIPIVLLMFVVVLLNHKKLDVLNLSDEIGISLGLNLEKERKKFLSFAVILAGVATAFAGNIGFLGLISPHIAKKLVGPYHKNFVVISAVISVIIILLADAVSRNLFSPIEIPVGITVSIFGVPYFIYLMMKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KA74</accession>
    <name>A0A174KA74_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisB</name>
        <name evidence="9" type="ORF">ERS852471_02916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZX01000024">
        <property type="protein sequence ID" value="CUP06210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055267779.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06210">
        <property type="protein sequence ID" value="CUP06210"/>
        <property type="gene ID" value="ERS852471_02916"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP06210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="261" mass="30742" checksum="1C79E1F1C2C9C66C" modified="2016-09-07" version="1">MHKVNYHTHTYRCGHAIGTELDYLNSALENKLNILGFSDHAPYPDDRLNLTKDTRMDYSELQDYIDTIRYLQIKYRNKIKILIGLEIEYDESVYSYYNYLLNYLSLDYLILGQHVFLSKGELLHTFSLNSTDSYVDYALSISKALETNFFKFLAHPDLIFINNLSWDENCDRACEIIIESAIKHDTILELNANGFRKGIMSFPDIDRYPYPHNKFWEKVAKTNLKVIINSDCHDPKFMWDSCMDQAYEYAKKLGLNIIYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KRK7</accession>
    <name>A0A174KRK7_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidA_5</name>
        <name evidence="1" type="ORF">ERS852471_03046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12657">
        <property type="protein sequence ID" value="CUP12657"/>
        <property type="gene ID" value="ERS852471_03046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="292" mass="32292" checksum="AA4C6E1E3C2AC6AF" modified="2016-09-07" version="1">MEGIDNIMSIKVIIMDVDGTLTNSKKVITEKTKETLLKAQEAGAKLILASGRPTSGLMDFAKELKMDKHNGLLVSFNGAKVVDCETNEVLFNQTMTVEEGQAVLEHMKKFKVKPMIDKGDYMYVNDVFDNEIEVNGKPFNIIQYESRGGKFKLCEKADLAAFADYPLNKILTAGEADYLAENYKAMMEPFKDKLSCMFTAPFYFEFTANGIDKAKALDTVLIPMGYKREEMIAFGDGHNDASMVKYAGIGVAMANAVEDLKAIADEITSSNEEDGIAVSLHEHMPELCLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KST7</accession>
    <name>A0A174KST7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ORF">ERS852471_03074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZX01000027">
        <property type="protein sequence ID" value="CUP13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268089.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13921">
        <property type="protein sequence ID" value="CUP13921"/>
        <property type="gene ID" value="ERS852471_03074"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09722">
        <property type="entry name" value="Cas1_I-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="332" mass="39349" checksum="66CBC3E2D45D3667" modified="2016-09-07" version="1">MGSTRYITSMGELTRKDNSLCFRKNGKNVYIPIENTKEIYCLNEVSINTKLLDFLASNNIVVHFFNYHQGYSGTYYPRNQYNSGKLLVKQVRKFDEDRLYAAKAIVRGIGINISEVLYHYYKHNKKEVKETIDWIRKEFLLAVEKSENINQLMSVEGEVWQRFYSDFKLFLPEDFIMNKRVKRPPDNPINAMISFGNTLLYTKTISSIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPVIVYKTIFDLINNRKIQVDKHFEKKVNYCLLNEEGRKIFIEAFEGRLESVFKHPKLKRNISYRTAIKLDCYKLIKWILEDKEFIPFSIKEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KUZ4</accession>
    <name>A0A174KUZ4_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852471_03109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP15822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268151.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15822">
        <property type="protein sequence ID" value="CUP15822"/>
        <property type="gene ID" value="ERS852471_03109"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1567942at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP15822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="143" mass="15501" checksum="153D2122FCA5335E" modified="2016-09-07" version="1">MLIFQTFSAFLATLGFGIIFNIKGKKLFFASLGGAIGWFFYSLSLKFNFSELSSLFISAIFFSSYCEIFARILKTPVTTLVICSLIPLVPGGGMYYTMLEAVNGNVSSSLDLGLNTLASAGTLALGIIFVSTITKLVTTHKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L1A0</accession>
    <name>A0A174L1A0_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">ERS852471_03118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CYZX01000028">
        <property type="protein sequence ID" value="CUP16237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268166.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16237">
        <property type="protein sequence ID" value="CUP16237"/>
        <property type="gene ID" value="ERS852471_03118"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP16237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="172" mass="18740" checksum="DE4E70764ECB090F" modified="2016-09-07" version="1">MNLKDKIRIVEGFPKEGISFKDITTLIGDGEAFKESIDLIVEHLKDKNVDVILGPEARGFIFGVPVAYALGVGFVPVRKKGKLPAETVSVDYALEYGVDVLEIHKDAIKKGQRVAIVDDLLATGGTIEAVAKLVEQVGGEVVSLDFAIELTELHGRDKLKGYEVMSLVQYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L5B7</accession>
    <name>A0A174L5B7_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galF_2</name>
        <name evidence="6" type="ORF">ERS852471_03145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZX01000029">
        <property type="protein sequence ID" value="CUP17647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268210.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17647">
        <property type="protein sequence ID" value="CUP17647"/>
        <property type="gene ID" value="ERS852471_03145"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP17647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="289" mass="32608" checksum="E3779F0502DDA696" modified="2016-09-07" version="1">MENKIRKAIIPAAGLGTRFLPATKAQPKEMLPIVDKPTLQYIIEECVASGIEEILIITGRNKKSIEDHFDRSVELEMELEKSGKQEMLEMVREISDMVNIHFIRQKEPRGLGHAIHCAKTFVGDEPFAVLLGDDVVYNEEKPCLKQLIDCYGEYKTSVLGVQTVAKKDVNKYGIVGGIHIEDRVYKVKDLVEKPSMEEAPSNVAILGRYIITPKIFEILENTAPGKGGEIQLTDALLQLIKEEAMYAYDFEGRRYDVGDKLGFLQATVEYALRKPELKDGFIEYLKTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L9T8</accession>
    <name>A0A174L9T8_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gutB</name>
        <name evidence="5" type="ORF">ERS852471_03175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CYZX01000031">
        <property type="protein sequence ID" value="CUP19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268261.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP19456">
        <property type="protein sequence ID" value="CUP19456"/>
        <property type="gene ID" value="ERS852471_03175"/>
    </dbReference>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="59"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="221"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="398" mass="43543" checksum="017F997052FBF7BF" modified="2016-09-07" version="1">MEINNINIEAIVKSILQEMTTGAEAPKAVSNANTAKVGMMTAKERIEIKEFNIPEISDDEMLVKVEGCGICGTDVHEYKNDPFGLIPVVLGHEGTGEIIKMGKNIKRDSAGKSLNVGDKIVTCIIPCGECPTCLQHPERTNLCENQGIYGLMTDDNIHLNGWFGDYIVIRKNSTVFNVSDMDLHSRVLIEPAAVVVHAVERAKTTGLLKFNSKVLVQGCGPIGLLLLSVLRTMGIENIVALDGNEKRLEMAKRLGATETVNVMKSSSFDETIEKIKDLTDGLGADFAFQCTGSPKAHAGIWKLVKRGGGLCEVGFFVNNGDATINPHFDLCNKEITAVGSWVYTPQDYLTTFDFLKRANGIGLPIKELITHEFPLEQLQEALETNIRQEGIKIAIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LAR9</accession>
    <name>A0A174LAR9_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000030">
        <property type="protein sequence ID" value="CUP18885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268248.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP18885">
        <property type="protein sequence ID" value="CUP18885"/>
        <property type="gene ID" value="ERS852471_03168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP18885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="187" mass="21750" checksum="BDA74A9AF707BEBC" modified="2016-09-07" version="1">MAILTKDGKAVDLSRGLQLGEIKDFKSRGLKKTKKGDIFECGNLEILLKNGVSLSQYIMVSPYNKYLFYKFVKAVGLEHKIDEYVDFPFCEMFDKEIVVELDYESVRGGRYLNVINVYSLEEAEEFIQYQKARDELKRRNGMLGMNFIEMVKERRAEIASNFNNTQEVEVNENEVTFGNEYEEFIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LH31</accession>
    <name>A0A174LH31_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852471_03251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23502">
        <property type="protein sequence ID" value="CUP23502"/>
        <property type="gene ID" value="ERS852471_03251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUP23502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="217" mass="26034" checksum="2CA3964EAE5AB58D" modified="2016-09-07" version="1">MMKKIIRLQLIYMVFWAITIILLCPSITEIYNYRDKNISVDEMINELKSEDMIEPVYFNIEETLRRVPEELIRKLYRIGITITTTDDIGENSEYGRVTSKYSHRSKTITIQKTYSNEVVLLHEIGHAISYNELPFIKLSDTCKFRKIYESEKDLIFPDGEKFYYRNFNVKYEYIKVNSEEYFAQCFSMYVLGTLPEETETYKFIQKYFKEKGIKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHQ6</accession>
    <name>A0A174LHQ6_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplJ</name>
        <name evidence="6" type="ORF">ERS852471_03230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000033">
        <property type="protein sequence ID" value="CUP22411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268358.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP22411">
        <property type="protein sequence ID" value="CUP22411"/>
        <property type="gene ID" value="ERS852471_03230"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP22411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="167" mass="18402" checksum="9FD62792A66ACE64" modified="2016-09-07" version="1">MNKNRTLKEAKVAEIKEKLEKAQGVALANYQGLTVEEDTMLRKSLREAGVEYKVYKNTLVTLAARELGLEDLVQHLEGPVSIAFGYEDATAPARVLFNFGKEHKKLELKAGVVEGIVYDKAGVEKLATIPSREVLIAKLLGSFKAPLSNLAYLLNAIKEKKESESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LL18</accession>
    <name>A0A174LL18_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">deoC</name>
        <name evidence="4" type="ORF">ERS852471_03247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CYZX01000035">
        <property type="protein sequence ID" value="CUP23337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268391.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23337">
        <property type="protein sequence ID" value="CUP23337"/>
        <property type="gene ID" value="ERS852471_03247"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP23337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="224" mass="23764" checksum="17C6022EC7DCA593" modified="2016-09-07" version="1">MENINIARMIDHTILKPEATEAEIMELCKEAVKYNFASVCVNPSMVAKAATILEGTPVKVCTVIGFPLGATTTEVKAFETEDAIKKGATEVDMVINVGKLKERDLAYVKNDIQAVVNAAKGKALTKVIIETCLLTDEEKVIACELSKEAGADFVKTSTGFSKGGATAHDIKLMRETVGPDMGVKASGGVRSREDALTMIENGATRIGASASIAICEGKESNSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LN16</accession>
    <name>A0A174LN16_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA_3</name>
        <name evidence="6" type="ORF">ERS852471_03282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZX01000038">
        <property type="protein sequence ID" value="CUP25493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268446.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25493">
        <property type="protein sequence ID" value="CUP25493"/>
        <property type="gene ID" value="ERS852471_03282"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP25493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="695" mass="76930" checksum="9A05D132E72885F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LY92</accession>
    <name>A0A174LY92_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852471_03299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000041">
        <property type="protein sequence ID" value="CUP26665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055268472.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26665">
        <property type="protein sequence ID" value="CUP26665"/>
        <property type="gene ID" value="ERS852471_03299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP26665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="309" mass="35742" checksum="8D68ECB8BA158B76" modified="2016-09-07" version="1">MSKQKNLRYQIIQVCKDNFRENIDKHSYYAQNGRDQADIIFSYTSKINIEKVGKNFAKFMKEEYPQIKKLSDIKANHVQSYLDGKVETCKDTTLKTYGGAMRKLEKLINNTYKSANLDYSSKIVIPKSECDDDTNRGVKAQISRDDYNKILDVAKNSSCQSAYAVRLQEHLGIRVSEIATLDRDKVHFSDDGTATINITNTKGGRSMSRELDEEGSALVKEILEQNFDDNKLFSIRSSSINDYLRDTEDILQIDRHSFHDIRRTLAQEFYDELREQGYSEKEAADQTSLFLNHNKDREALLKRSYINLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M0A2</accession>
    <name>A0A174M0A2_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852471_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZX01000043">
        <property type="protein sequence ID" value="CUP27608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27608">
        <property type="protein sequence ID" value="CUP27608"/>
        <property type="gene ID" value="ERS852471_03315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="41"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP27608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="211" mass="24706" checksum="376BCBAF39FE3B1C" modified="2016-09-07" version="1">MKRVQRRMTELGLCAVTVKKYKPHSSKKVAEDLENVLKRDFTTTSINEKWVGDITYIYTIKDGWCYLASVLDLYSKKIIGYAFGQRMTNDLVVKALKNAYYSQSPDKNKQLIFHSDLGSQYTSNDLRELCKEFNIIQSFSKKGCPYDNACIESFHSLIKKEEIYRNTYRTFEEVNMAIFKYIEGWYNRKRLHSSINYMTPDQCELLARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6S0</accession>
    <name>A0A174C6S0_9CLOT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_4</name>
        <name evidence="6" type="ORF">ERS852471_00930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834856</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZX01000005">
        <property type="protein sequence ID" value="CUO08854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264423.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08854">
        <property type="protein sequence ID" value="CUO08854"/>
        <property type="gene ID" value="ERS852471_00930"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO08854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="340" mass="38274" checksum="F9C3A651E37A9C12" modified="2016-09-07" version="1">MKPLIEVKNLTIEFFLKNGKLRACDNVSFTIYKNEVLGVIGESGSGKSTLASGILNLVQAPGKITSGEVYYYDEDDKKVNLLELSTDEFNEYRWKEIATVFQAAQNALNPVLKIKEHFIETVLAHDPGRTVEDIIKKAEEVLRYVRLDTNVLEYYPHQLSGGMKQRVLIALSLVLDPKVILLDEPTTALDVITQWYILDLLKDIHERLGVTLIFLTHDISVISGVIDRIAVMYAGELVEFGEVADVFEEPSHPYTKGLLNAIPTLNDDVTQRKAIPGNPPNLTQEFNECKFSPRCSIFLAGECKGSREKTKVMYFVNDTKCTRCYEFAERLTTVKSEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWI3</accession>
    <name>A0A174DWI3_9CLOT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pfp_2</name>
        <name evidence="10" type="synonym">pfkA</name>
        <name evidence="12" type="ORF">ERS852471_01270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium disporicum</name>
        <dbReference type="NCBI Taxonomy" id="84024"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834856</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="CYZX01000007">
        <property type="protein sequence ID" value="CUO28240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055264821.1">
        <property type="nucleotide sequence ID" value="NZ_CYZX01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28240">
        <property type="protein sequence ID" value="CUO28240"/>
        <property type="gene ID" value="ERS852471_01270"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095594">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="7"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO28240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095594"/>
        </source>
    </evidence>
    <sequence length="366" mass="39479" checksum="D52616919BE1EAB1" modified="2016-09-07" version="1">MAQEIKKIALLTGGGDCPGLNAVIRAVTKAAILNYGMEVIGYKFGYRGLYKNDFVPLTLDSVSGILNRGGTILYSSNKDNLFDYQVEENGVQVKKDVSDVAIENLKKEGVDVLIVIGGDGTLTSARDFSRKGVKVIGVPKTIDNDLASTDVTFGFNTAIDVVTEALDRLHTTAESHHRIMLCEVMGRNAGWIALEAGIAGSADVILIPEIAYDINKIAEKVREREAQGKNFTIIVVAEGAKPKNGEVVVSKIVKDSPDPIRLGGIGNKLAEDLERLIVDHEVRCTVLGHIQRGGNTSTYDRILSTRYGVAAVELIREGKFGHMVCLKGDTISSDTLENVIGKQTKLVNPEGELVQVAKKIGVTFAE</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>